Medical College of Wisconsin
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Mahfoud Assem PharmD

Associate Professor

Institution: Medical College of Wisconsin
Department: School of Pharmacy Administration
Division: Administration
Program: Program Development

Publications (37)

  • Gene expression and immunochemical localization of major cytochrome P450 drug-metabolizing enzymes in bovine nasal olfactory and respiratory mucosa. (Dhamankar V, Assem M, Donovan MD) Inhal Toxicol 2015;27(14):767-77 PMID: 26572092 PMCID: PMC4970319 11/18/2015       5 Citations
  • Microarray Determination of the Expression of Drug Transporters in Humans and Animal Species Used for the Investigation of Nasal Absorption. (Al-Ghabeish M, Scheetz T, Assem M, Donovan MD) Mol Pharm 2015 Aug 03;12(8):2742-54 PMID: 26106909 PMCID: PMC4671632 06/25/2015       15 Citations
  • NOTCH3 is a prognostic factor that promotes glioma cell proliferation, migration and invasion via activation of CCND1 and EGFR. (Alqudah MA, Agarwal S, Al-Keilani MS, Sibenaller ZA, Ryken TC, Assem M) PLoS One 2013;8(10):e77299 PMID: 24143218 PMCID: PMC3797092 10/22/2013       30 Citations
  • Tumor derived mutations of protein tyrosine phosphatase receptor type k affect its function and alter sensitivity to chemotherapeutics in glioma. (Agarwal S, Al-Keilani MS, Alqudah MA, Sibenaller ZA, Ryken TC, Assem M) PLoS One 2013;8(5):e62852 PMID: 23696788 PMCID: PMC3656086 05/23/2013       20 Citations
  • Enhancing diagnosis, prognosis, and therapeutic outcome prediction of gliomas using genomics. (Assem M, Sibenaller Z, Agarwal S, Al-Keilani MS, Alqudah MA, Ryken TC) OMICS 2012 Mar;16(3):113-22 PMID: 22401657 PMCID: PMC3300066 03/10/2012       20 Citations
  • Constitutive androstane receptor activation decreases plasma apolipoprotein B-containing lipoproteins and atherosclerosis in low-density lipoprotein receptor-deficient mice. (Sberna AL, Assem M, Xiao R, Ayers S, Gautier T, Guiu B, Deckert V, Chevriaux A, Grober J, Le Guern N, Pais de Barros JP, Moore DD, Lagrost L, Masson D) Arterioscler Thromb Vasc Biol 2011 Oct;31(10):2232-9 PMID: 21778422 PMCID: PMC4104927 07/23/2011       21 Citations
  • Constitutive androstane receptor activation stimulates faecal bile acid excretion and reverse cholesterol transport in mice. (Sberna AL, Assem M, Gautier T, Grober J, Guiu B, Jeannin A, Pais de Barros JP, Athias A, Lagrost L, Masson D) J Hepatol 2011 Jul;55(1):154-61 PMID: 21145854 12/15/2010       25 Citations
  • The major human pregnane X receptor (PXR) splice variant, PXR.2, exhibits significantly diminished ligand-activated transcriptional regulation. (Lin YS, Yasuda K, Assem M, Cline C, Barber J, Li CW, Kholodovych V, Ai N, Chen JD, Welsh WJ, Ekins S, Schuetz EG) Drug Metab Dispos 2009 Jun;37(6):1295-304 PMID: 19251824 PMCID: PMC2683691 03/03/2009       28 Citations
  • The SWI/SNF chromatin-remodeling complex and glucocorticoid resistance in acute lymphoblastic leukemia. (Pottier N, Yang W, Assem M, Panetta JC, Pei D, Paugh SW, Cheng C, Den Boer ML, Relling MV, Pieters R, Evans WE, Cheok MH) J Natl Cancer Inst 2008 Dec 17;100(24):1792-803 PMID: 19066270 PMCID: PMC2639326 12/11/2008       44 Citations
  • Activation of the constitutive androstane receptor decreases HDL in wild-type and human apoA-I transgenic mice. (Masson D, Qatanani M, Sberna AL, Xiao R, Pais de Barros JP, Grober J, Deckert V, Athias A, Gambert P, Lagrost L, Moore DD, Assem M) J Lipid Res 2008 Aug;49(8):1682-91 PMID: 18441373 04/29/2008       32 Citations
  • Expression of SMARCB1 modulates steroid sensitivity in human lymphoblastoid cells: identification of a promoter SNP that alters PARP1 binding and SMARCB1 expression. (Pottier N, Cheok MH, Yang W, Assem M, Tracey L, Obenauer JC, Panetta JC, Relling MV, Evans WE) Hum Mol Genet 2007 Oct 01;16(19):2261-71 PMID: 17616514 07/10/2007       38 Citations
  • A common polymorphism in the bile acid receptor farnesoid X receptor is associated with decreased hepatic target gene expression. (Marzolini C, Tirona RG, Gervasini G, Poonkuzhali B, Assem M, Lee W, Leake BF, Schuetz JD, Schuetz EG, Kim RB) Mol Endocrinol 2007 Aug;21(8):1769-80 PMID: 17519356 05/24/2007       55 Citations
  • ADME transcriptome in Hispanic versus White donor livers: evidence of a globally enhanced NR1I3 (CAR, constitutive androstane receptor) gene signature in Hispanics. (Finkelstein D, Lamba V, Assem M, Rengelshausen J, Yasuda K, Strom S, Schuetz E) Xenobiotica 2006 Oct-Nov;36(10-11):989-1012 PMID: 17118917 11/23/2006       11 Citations
  • Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia. (Zhou C, Assem M, Tay JC, Watkins PB, Blumberg B, Schuetz EG, Thummel KE) J Clin Invest 2006 Jun;116(6):1703-12 PMID: 16691293 PMCID: PMC1459072 05/13/2006       191 Citations
  • Human apoA-I expression in CETP transgenic rats leads to lower levels of apoC-I in HDL and to magnification of CETP-mediated lipoprotein changes. (Masson D, Pais de Barros JP, Zak Z, Gautier T, Le Guern N, Assem M, Chisholm JW, Paterniti JR Jr, Lagrost L) J Lipid Res 2006 Feb;47(2):356-65 PMID: 16282639 11/12/2005       6 Citations
  • Expression of the pregnane X receptor in mice antagonizes the cholic acid-mediated changes in plasma lipoprotein profile. (Masson D, Lagrost L, Athias A, Gambert P, Brimer-Cline C, Lan L, Schuetz JD, Schuetz EG, Assem M) Arterioscler Thromb Vasc Biol 2005 Oct;25(10):2164-9 PMID: 16123326 08/27/2005       24 Citations
  • PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators. (Lamba V, Yasuda K, Lamba JK, Assem M, Davila J, Strom S, Schuetz EG) Toxicol Appl Pharmacol 2004 Sep 15;199(3):251-65 PMID: 15364541 09/15/2004       154 Citations
  • Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences. (Lamba JK, Lamba V, Yasuda K, Lin YS, Assem M, Thompson E, Strom S, Schuetz E) J Pharmacol Exp Ther 2004 Nov;311(2):811-21 PMID: 15194709 06/15/2004       87 Citations
  • PharmGKB update: II. CYP3A5, cytochrome P450, family 3, subfamily A, polypeptide 5. (Schuetz EG, Relling MV, Kishi S, Yang W, Das S, Chen P, Cook EH, Rosner GL, Pui CH, Blanco JG, Edick MJ, Hancock ML, Winick NJ, Dervieux T, Amylon MD, Bash RO, Behm FG, Camitta BM, Raimondi SC, Goh BC, Lee SC, Wang LZ, Fan L, Guo JY, Lamba J, Lim R, Lim HL, Ong AB, Lee HS, Kuehl P, Zhang J, Lin Y, Assem M, Schuetz J, Watkins PB, Daly A, Wrighton SA, Hall SD, Maurel P, Brimer C, Yasuda K, Venkataramanan R, Strom S, Thummel K, Boguski MS) Pharmacol Rev 2004 Jun;56(2):159 PMID: 15169924 06/01/2004       26 Citations
  • Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. (Assem M, Schuetz EG, Leggas M, Sun D, Yasuda K, Reid G, Zelcer N, Adachi M, Strom S, Evans RM, Moore DD, Borst P, Schuetz JD) J Biol Chem 2004 May 21;279(21):22250-7 PMID: 15004017 03/09/2004       207 Citations
  • Stage-dependent activation of cell cycle and apoptosis mechanisms in the right ventricle by pressure overload. (Ecarnot-Laubriet A, Assem M, Poirson-Bichat F, Moisant M, Bernard C, Lecour S, Solary E, Rochette L, Teyssier JR) Biochim Biophys Acta 2002 Apr 24;1586(3):233-42 PMID: 11997075 05/09/2002       25 Citations
  • Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450. (Schuetz EG, Strom S, Yasuda K, Lecureur V, Assem M, Brimer C, Lamba J, Kim RB, Ramachandran V, Komoroski BJ, Venkataramanan R, Cai H, Sinal CJ, Gonzalez FJ, Schuetz JD) J Biol Chem 2001 Oct 19;276(42):39411-8 PMID: 11509573 08/18/2001       338 Citations
  • Changes in HSP70 and P53 expression are related to the pattern of electromechanical alterations in rat cardiomyocytes during simulated ischemia. (Laubriet A, Fantini E, Assem M, Cordelet C, Teyssier JR, Athias P, Rochette L) Mol Cell Biochem 2001 Apr;220(1-2):77-86 PMID: 11451386 07/14/2001       10 Citations
  • [Expression of p21 WAF1/CIP1 protein in colorectal cancers: study of its relation to p53 mutation and Ki67 antigen expression]. (Chapusot C, Assem M, Martin L, Chalabreyssse L, Benhamiche AM, Lignier MA, Chauffert B, Teyssier JR, Faivre J, Piard F) Pathol Biol (Paris) 2001 Mar;49(2):115-23 PMID: 11317955 04/25/2001       2 Citations
  • Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. (Kuehl P, Zhang J, Lin Y, Lamba J, Assem M, Schuetz J, Watkins PB, Daly A, Wrighton SA, Hall SD, Maurel P, Relling M, Brimer C, Yasuda K, Venkataramanan R, Strom S, Thummel K, Boguski MS, Schuetz E) Nat Genet 2001 Apr;27(4):383-91 PMID: 11279519 03/30/2001       1774 Citations
  • Downregulation and nuclear relocation of MLP during the progression of right ventricular hypertrophy induced by chronic pressure overload. (Ecarnot-Laubriet A, De Luca K, Vandroux D, Moisant M, Bernard C, Assem M, Rochette L, Teyssier JR) J Mol Cell Cardiol 2000 Dec;32(12):2385-95 PMID: 11113014 12/13/2000       50 Citations
  • Are there several types of colorectal carcinomas? Correlations with genetic data. (Martin L, Assem M, Piard F) Eur J Cancer Prev 1999 Dec;8 Suppl 1:S13-20 PMID: 10772413 04/20/2000       19 Citations
  • Antioxidative properties of pyruvate and protection of the ischemic rat heart during cardioplegia. (Dobsak P, Courderot-Masuyer C, Zeller M, Vergely C, Laubriet A, Assem M, Eicher JC, Teyssier JR, Wolf JE, Rochette L) J Cardiovasc Pharmacol 1999 Nov;34(5):651-9 PMID: 10547080 11/05/1999       100 Citations
  • Alteration of sialyl Lewis epitope expression in pterygium. (Creuzot-Garcher C, Guerzider V, Assem M, Bron AM, Delannoy P, Bara J) Invest Ophthalmol Vis Sci 1999 Jul;40(8):1631-6 PMID: 10393028 07/07/1999       15 Citations
  • Irreversible glomerular lesions induced by crystal precipitation in a renal transplant after foscarnet therapy for cytomegalovirus infection. (Justrabo E, Zanetta G, Martin L, Assem M, Mousson C, Maurice-Estepa L, Rifle G, Tanter Y) Histopathology 1999 Apr;34(4):365-9 PMID: 10231404 05/07/1999       15 Citations
  • Changes of the inducible heat shock protein 70 mRNA level in rat retina after ischemia and reperfusion. (Lewden O, Garcher C, Assem M, Morales C, Rochette L, Bron AM) Ophthalmic Res 1998;30(5):291-4 PMID: 9704332 08/15/1998       16 Citations
  • Solitary plasmacytoma of the lung with light chain extracellular deposits: a case report and review of the literature. (Piard F, Yaziji N, Jarry O, Assem M, Martin L, Bernard A, Jacquot JP, Justrabo E) Histopathology 1998 Apr;32(4):356-61 PMID: 9602333 05/29/1998       38 Citations
  • Pattern of superoxide dismutase enzymatic activity and RNA changes in rat heart ventricles after myocardial infarction. (Assem M, Teyssier JR, Benderitter M, Terrand J, Laubriet A, Javouhey A, David M, Rochette L) Am J Pathol 1997 Aug;151(2):549-55 PMID: 9250167 PMCID: PMC1858014 08/01/1997       35 Citations
  • Inconstant association between 27-kDa heat-shock protein (Hsp27) content and doxorubicin resistance in human colon cancer cells. The doxorubicin-protecting effect of Hsp27. (Garrido C, Mehlen P, Fromentin A, Hammann A, Assem M, Arrigo AP, Chauffert B) Eur J Biochem 1996 May 01;237(3):653-9 PMID: 8647109 05/01/1996       78 Citations
  • Effect of in vivo heart irradiation on the development of antioxidant defenses and cardiac functions in the rat. (Benderitter M, Maingon P, Abadie C, Assem M, Maupoil V, Briot F, Horiot JC, Rochette L) Radiat Res 1995 Oct;144(1):64-72 PMID: 7568773 10/01/1995       17 Citations
  • Circumvention of confluence-dependent resistance in a human multi-drug-resistant colon-cancer cell line. (Garrido C, Chauffert B, Pinard D, Tibaut F, Genne P, Assem M, Dimanche-Boitrel MT) Int J Cancer 1995 Jun 09;61(6):873-9 PMID: 7790124 06/09/1995       22 Citations
  • Deleterious effect of serum proteins on the amphotericin B-induced potentiation of cisplatin in human colon cancer cells. (Assem M, Bonvalot S, Beltramo JL, Garrido C, Dimanche-Boitrel MT, Genne P, Rebibou JM, Caillot D, Chauffert B) Br J Cancer 1994 Oct;70(4):631-5 PMID: 7917908 PMCID: PMC2033400 10/01/1994       22 Citations
  • Last update: 08/01/2018