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Melinda R. Dwinell PhD

Melinda R. Dwinell PhD profile photo picture


Institution: Medical College of Wisconsin
Department: Physiology
Program: Genetics

Member of the Cancer Center
Member of the Cardiovascular Center
Member of the Genomic Sciences and Precision Medicine Center (GSPMC)

Research Experience

  • Cardiovascular Physiological Phenomena
  • Circulatory and Respiratory Physiological Phenomena
  • Phenotype
  • Respiratory Physiological Phenomena
  • Methodologies and Techniques

  • Airway Resistance
  • Monitoring, Physiologic
  • Plethysmography, Whole Body
  • MCW Program / Core Facilities

  • Rat Research Models Service Center
  • Publications (99)

  • Mutation of RORγT reveals a role for Th17 cells in both injury and recovery from renal ischemia-reperfusion injury. (Mehrotra P, Ullah MM, Collett JA, Myers SL, Dwinell MR, Geurts AM, Basile DP) Am J Physiol Renal Physiol 2020 Nov 01;319(5):F796-F808 PMID: 32924545 SCOPUS ID: 2-s2.0-85094221372 09/15/2020    
  • Transcriptional analysis of the multiple Sry genes and developmental program at the onset of testis differentiation in the rat. (Prokop JW, Chhetri SB, van Veen JE, Chen X, Underwood AC, Uhl K, Dwinell MR, Geurts AM, Correa SM, Arnold AP) Biol Sex Differ 2020 05 12;11(1):28 PMID: 32398044 PMCID: PMC7216353 SCOPUS ID: 2-s2.0-85084627810 05/14/2020    
  • Chromosomal Substitution Strategies to Localize Genomic Regions Related to Complex Traits. (Cowley AW Jr, Dwinell MR) Compr Physiol 2020 03 12;10(2):365-388 PMID: 32163204 SCOPUS ID: 2-s2.0-85081890516 03/13/2020    
  • Robust and replicable measurement for prepulse inhibition of the acoustic startle response. (Miller EA, Kastner DB, Grzybowski MN, Dwinell MR, Geurts AM, Frank LM) Mol Psychiatry 2020 Mar 06 PMID: 32144356 PMCID: PMC7483293 SCOPUS ID: 2-s2.0-85081733376 03/08/2020       1 Citation
  • The Year of the Rat: The Rat Genome Database at 20: a multi-species knowledgebase and analysis platform. (Smith JR, Hayman GT, Wang SJ, Laulederkind SJF, Hoffman MJ, Kaldunski ML, Tutaj M, Thota J, Nalabolu HS, Ellanki SLR, Tutaj MA, De Pons JL, Kwitek AE, Dwinell MR, Shimoyama ME) Nucleic Acids Res 2020 01 08;48(D1):D731-D742 PMID: 31713623 PMCID: PMC7145519 SCOPUS ID: 2-s2.0-85077666371 11/13/2019       4 Citations
  • Precision Medicine and Precision Public Health: Academic Education and Community Engagement. (Meurer JR, Whittle JC, Lamb KM, Kosasih MA, Dwinell MR, Urrutia RA) Am J Prev Med 2019 08;57(2):286-289 PMID: 31326012 SCOPUS ID: 2-s2.0-85068737878 07/22/2019    
  • Rat Genome Databases, Repositories, and Tools. (Laulederkind SJF, Hayman GT, Wang SJ, Hoffman MJ, Smith JR, Bolton ER, De Pons J, Tutaj MA, Tutaj M, Thota J, Dwinell MR, Shimoyama M) Methods Mol Biol 2019;2018:71-96 PMID: 31228152 SCOPUS ID: 2-s2.0-85068143710 06/23/2019       5 Citations
  • The Rat: A Model Used in Biomedical Research. (Smith JR, Bolton ER, Dwinell MR) Methods Mol Biol 2019;2018:1-41 PMID: 31228150 SCOPUS ID: 2-s2.0-85068179700 06/23/2019       2 Citations
  • Quantitative phenotype analysis to identify, validate and compare rat disease models. (Zhao Y, Smith JR, Wang SJ, Dwinell MR, Shimoyama M) Database (Oxford) 2019 01 01;2019 PMID: 30938777 PMCID: PMC6444380 SCOPUS ID: 2-s2.0-85064202973 04/03/2019       1 Citation
  • Identification of a Rat Mammary Tumor Risk Locus That Is Syntenic with the Commonly Amplified 8q12.1 and 8q22.1 Regions in Human Breast Cancer Patients. (Plasterer C, Tsaih SW, Lemke A, Schilling R, Dwinell M, Rau A, Auer P, Rui H, Flister MJ) G3 (Bethesda) 2019 05 07;9(5):1739-1743 PMID: 30914425 PMCID: PMC6505137 SCOPUS ID: 2-s2.0-85065792535 03/28/2019       2 Citations
  • Integrated curation and data mining for disease and phenotype models at the Rat Genome Database. (Wang SJ, Laulederkind SJF, Zhao Y, Hayman GT, Smith JR, Tutaj M, Thota J, Tutaj MA, Hoffman MJ, Bolton ER, De Pons J, Dwinell MR, Shimoyama M) Database (Oxford) 2019 01 01;2019 PMID: 30753478 PMCID: PMC6369425 SCOPUS ID: 2-s2.0-85061482732 02/13/2019       1 Citation
  • Integrating biology with rat genomic tools (Dwinell MR, Geurts AM) The Laboratory Rat 1 January 2019:811-825 SCOPUS ID: 2-s2.0-85094602754 01/01/2019    
  • The Gene Ontology Resource: 20 years and still GOing strong. (The Gene Ontology Consortium) Nucleic Acids Res 2019 01 08;47(D1):D330-D338 PMID: 30395331 PMCID: PMC6323945 SCOPUS ID: 2-s2.0-85059799086 11/06/2018       690 Citations
  • Sdha+/- Rats Display Minimal Muscle Pathology Without Significant Behavioral or Biochemical Abnormalities. (Siebers EM, Choi MJ, Tinklenberg JA, Beatka MJ, Ayres S, Meng H, Helbling DC, Takizawa A, Bennett B, Garces AM, Dias Duarte Machado LG, Dimmock D, Dwinell MR, Geurts AM, Lawlor MW) J Neuropathol Exp Neurol 2018 08 01;77(8):665-672 PMID: 29850869 PMCID: PMC6044411 SCOPUS ID: 2-s2.0-85054028838 06/01/2018       2 Citations
  • A Primer for the Rat Genome Database (RGD). (Laulederkind SJF, Hayman GT, Wang SJ, Smith JR, Petri V, Hoffman MJ, De Pons J, Tutaj MA, Ghiasvand O, Tutaj M, Thota J, Dwinell MR, Shimoyama M) Methods Mol Biol 2018;1757:163-209 PMID: 29761460 PMCID: PMC6487669 SCOPUS ID: 2-s2.0-85047123695 05/16/2018       5 Citations
  • Rat Genome and Model Resources. (Shimoyama M, Smith JR, Bryda E, Kuramoto T, Saba L, Dwinell M) ILAR J 2017 07 01;58(1):42-58 PMID: 28838068 PMCID: PMC6057551 SCOPUS ID: 2-s2.0-85028342548 08/26/2017       21 Citations
  • Haploid embryonic stem cell lines derived from androgenetic and parthenogenetic rat blastocysts. (Hirabayashi M, Hara H, Goto T, Takizawa A, Dwinell MR, Yamanaka T, Hochi S, Nakauchi H) J Reprod Dev 2017 Dec 15;63(6):611-616 PMID: 28824040 PMCID: PMC5735273 SCOPUS ID: 2-s2.0-85040115487 08/22/2017       1 Citation
  • Host genetic modifiers of nonproductive angiogenesis inhibit breast cancer. (Flister MJ, Tsaih SW, Stoddard A, Plasterer C, Jagtap J, Parchur AK, Sharma G, Prisco AR, Lemke A, Murphy D, Al-Gizawiy M, Straza M, Ran S, Geurts AM, Dwinell MR, Greene AS, Bergom C, LaViolette PS, Joshi A) Breast Cancer Res Treat 2017 Aug;165(1):53-64 PMID: 28567545 PMCID: PMC6404538 SCOPUS ID: 2-s2.0-85020059895 06/02/2017       9 Citations
  • Lung injury pathways: Adenosine receptor 2B signaling limits development of ischemic bronchiolitis obliterans organizing pneumonia. (Densmore JC, Schaid TR, Jeziorczak PM, Medhora M, Audi S, Nayak S, Auchampach J, Dwinell MR, Geurts AM, Jacobs ER) Exp Lung Res 2017 02;43(1):38-48 PMID: 28266889 PMCID: PMC5831175 SCOPUS ID: 2-s2.0-85014510215 03/08/2017       3 Citations
  • Expansion of the Gene Ontology knowledgebase and resources. (The Gene Ontology Consortium) Nucleic Acids Res 2017 01 04;45(D1):D331-D338 PMID: 27899567 PMCID: PMC5210579 SCOPUS ID: 2-s2.0-85016166168 12/03/2016       852 Citations
  • Exploring human disease using the Rat Genome Database. (Shimoyama M, Laulederkind SJ, De Pons J, Nigam R, Smith JR, Tutaj M, Petri V, Hayman GT, Wang SJ, Ghiasvand O, Thota J, Dwinell MR) Dis Model Mech 2016 10 01;9(10):1089-1095 PMID: 27736745 PMCID: PMC5087824 SCOPUS ID: 2-s2.0-84993949779 10/14/2016       18 Citations
  • Disease, Models, Variants and Altered Pathways-Journeying RGD Through the Magnifying Glass. (Petri V, Hayman GT, Tutaj M, Smith JR, Laulederkind S, Wang SJ, Nigam R, De Pons J, Shimoyama M, Dwinell MR) Comput Struct Biotechnol J 2016;14:35-48 PMID: 27602200 PMCID: PMC4700298 SCOPUS ID: 2-s2.0-84961710673 09/08/2016    
  • Comprehensive coverage of cardiovascular disease data in the disease portals at the Rat Genome Database. (Wang SJ, Laulederkind SJ, Hayman GT, Petri V, Smith JR, Tutaj M, Nigam R, Dwinell MR, Shimoyama M) Physiol Genomics 2016 08 01;48(8):589-600 PMID: 27287925 PMCID: PMC5005459 SCOPUS ID: 2-s2.0-84983740999 06/12/2016       2 Citations
  • The Disease Portals, disease-gene annotation and the RGD disease ontology at the Rat Genome Database. (Hayman GT, Laulederkind SJ, Smith JR, Wang SJ, Petri V, Nigam R, Tutaj M, De Pons J, Dwinell MR, Shimoyama M) Database (Oxford) 2016;2016 PMID: 27009807 PMCID: PMC4805243 SCOPUS ID: 2-s2.0-84964901900 03/25/2016       10 Citations
  • Report of the National Heart, Lung, and Blood Institute Working Group on Sex Differences Research in Cardiovascular Disease: Scientific Questions and Challenges. (Maric-Bilkan C, Arnold AP, Taylor DA, Dwinell M, Howlett SE, Wenger N, Reckelhoff JF, Sandberg K, Churchill G, Levin E, Lundberg MS) Hypertension 2016 May;67(5):802-7 PMID: 26975706 PMCID: PMC4833564 SCOPUS ID: 2-s2.0-84961233476 03/16/2016       37 Citations
  • Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease. (Rubattu S, Di Castro S, Schulz H, Geurts AM, Cotugno M, Bianchi F, Maatz H, Hummel O, Falak S, Stanzione R, Marchitti S, Scarpino S, Giusti B, Kura A, Gensini GF, Peyvandi F, Mannucci PM, Rasura M, Sciarretta S, Dwinell MR, Hubner N, Volpe M) J Am Heart Assoc 2016 Feb 17;5(2) PMID: 26888427 PMCID: PMC4802485 SCOPUS ID: 2-s2.0-84995488392 02/19/2016    
  • The phenotypic impact of the male-specific region of chromosome-Y in inbred mating: the role of genetic variants and gene duplications in multiple inbred rat strains. (Prokop JW, Tsaih SW, Faber AB, Boehme S, Underwood AC, Troyer S, Playl L, Milsted A, Turner ME, Ely D, Martins AS, Tutaj M, Lazar J, Dwinell MR, Jacob HJ) Biol Sex Differ 2016;7:10 PMID: 26848384 PMCID: PMC4740989 SCOPUS ID: 2-s2.0-84957567774 02/06/2016    
  • Rat Breeding Parameters According to Floor Space Available in Cage. (Allen KP, Dwinell MR, Zappa AM, Michaels AM, Murray KM, Thulin JD) J Am Assoc Lab Anim Sci 2016 Jan;55(1):21-4 PMID: 26817975 PMCID: PMC4747006 SCOPUS ID: 2-s2.0-84958177394 01/29/2016       3 Citations
  • Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension. (Nayak S, Khan MA, Wan TC, Pei H, Linden J, Dwinell MR, Geurts AM, Imig JD, Auchampach JA) Purinergic Signal 2015 Dec;11(4):519-31 PMID: 26385692 PMCID: PMC4648794 SCOPUS ID: 2-s2.0-84947616348 09/20/2015       6 Citations
  • 2015 Guidelines for Establishing Genetically Modified Rat Models for Cardiovascular Research. (Flister MJ, Prokop JW, Lazar J, Shimoyama M, Dwinell M, Geurts A, International Committee on Standardized Genetic Nomenclature for Mice, Rat Genome and Nomenclature Committee) J Cardiovasc Transl Res 2015 Jun;8(4):269-77 PMID: 25920443 PMCID: PMC4475456 SCOPUS ID: 2-s2.0-84931568348 04/30/2015       18 Citations
  • PhenoMiner: a quantitative phenotype database for the laboratory rat, Rattus norvegicus. Application in hypertension and renal disease. (Wang SJ, Laulederkind SJ, Hayman GT, Petri V, Liu W, Smith JR, Nigam R, Dwinell MR, Shimoyama M) Database (Oxford) 2015;2015 PMID: 25632109 PMCID: PMC4309021 SCOPUS ID: 2-s2.0-84943179091 01/30/2015       9 Citations
  • OntoMate: a text-mining tool aiding curation at the Rat Genome Database. (Liu W, Laulederkind SJ, Hayman GT, Wang SJ, Nigam R, Smith JR, De Pons J, Dwinell MR, Shimoyama M) Database (Oxford) 2015;2015 PMID: 25619558 PMCID: PMC4305386 SCOPUS ID: 2-s2.0-85051605173 01/27/2015       8 Citations
  • Gene Ontology Consortium: going forward. (Gene Ontology Consortium) Nucleic Acids Res 2015 Jan;43(Database issue):D1049-56 PMID: 25428369 PMCID: PMC4383973 SCOPUS ID: 2-s2.0-84946735654 11/28/2014       1499 Citations
  • Enhancement of resting-state fcMRI networks by prior sensory stimulation. (Li C, Li Z, Ward BD, Dwinell MR, Lombard JH, Hudetz AG, Pawela CP) Brain Connect 2014 Nov;4(9):760-8 PMID: 25387238 PMCID: PMC4238242 SCOPUS ID: 2-s2.0-84937199899 11/12/2014       4 Citations
  • The Rat Genome Database 2015: genomic, phenotypic and environmental variations and disease. (Shimoyama M, De Pons J, Hayman GT, Laulederkind SJ, Liu W, Nigam R, Petri V, Smith JR, Tutaj M, Wang SJ, Worthey E, Dwinell M, Jacob H) Nucleic Acids Res 2015 Jan;43(Database issue):D743-50 PMID: 25355511 PMCID: PMC4383884 SCOPUS ID: 2-s2.0-84941092929 10/31/2014       137 Citations
  • Disease pathways at the Rat Genome Database Pathway Portal: genes in context-a network approach to understanding the molecular mechanisms of disease. (Petri V, Hayman GT, Tutaj M, Smith JR, Laulederkind SJ, Wang SJ, Nigam R, De Pons J, Shimoyama M, Dwinell MR, Worthey EA, Jacob HJ) Hum Genomics 2014 Sep 30;8:17 PMID: 25265995 PMCID: PMC4191248 SCOPUS ID: 2-s2.0-84964312855 10/01/2014       6 Citations
  • The pathway ontology - updates and applications. (Petri V, Jayaraman P, Tutaj M, Hayman GT, Smith JR, De Pons J, Laulederkind SJ, Lowry TF, Nigam R, Wang SJ, Shimoyama M, Dwinell MR, Munzenmaier DH, Worthey EA, Jacob HJ) J Biomed Semantics 2014 Feb 05;5(1):7 PMID: 24499703 PMCID: PMC3922094 SCOPUS ID: 2-s2.0-84927942575 02/07/2014    
  • Amelioration of salt-induced vascular dysfunction in mesenteric arteries of Dahl salt-sensitive rats by missense mutation of extracellular superoxide dismutase. (Beyer AM, Raffai G, Weinberg BD, Fredrich K, Rodgers MS, Geurts AM, Jacob HJ, Dwinell MR, Lombard JH) Am J Physiol Heart Circ Physiol 2014 Feb;306(3):H339-47 PMID: 24322611 PMCID: PMC3920146 SCOPUS ID: 2-s2.0-84893409421 12/11/2013       8 Citations
  • Rat Strain Ontology: structured controlled vocabulary designed to facilitate access to strain data at RGD. (Nigam R, Munzenmaier DH, Worthey EA, Dwinell MR, Shimoyama M, Jacob HJ) J Biomed Semantics 2013 Nov 22;4(1):36 PMID: 24267899 PMCID: PMC4177145 SCOPUS ID: 2-s2.0-84943184308 11/26/2013    
  • The clinical measurement, measurement method and experimental condition ontologies: expansion, improvements and new applications. (Smith JR, Park CA, Nigam R, Laulederkind SJ, Hayman GT, Wang SJ, Lowry TF, Petri V, Pons JD, Tutaj M, Liu W, Worthey EA, Shimoyama M, Dwinell MR) J Biomed Semantics 2013 Oct 08;4(1):26 PMID: 24103152 PMCID: PMC3882879 SCOPUS ID: 2-s2.0-84978081999 10/10/2013    
  • FMRI and fcMRI phenotypes map the genomic effect of chromosome 13 in Brown Norway and Dahl salt-sensitive rats. (Li Z, Ward BD, Dwinell MR, Lombard JH, Pawela CP) Neuroimage 2014 Apr 15;90:403-12 PMID: 24084065 SCOPUS ID: 2-s2.0-84893717855 10/03/2013       2 Citations
  • Identifying multiple causative genes at a single GWAS locus. (Flister MJ, Tsaih SW, O'Meara CC, Endres B, Hoffman MJ, Geurts AM, Dwinell MR, Lazar J, Jacob HJ, Moreno C) Genome Res 2013 Dec;23(12):1996-2002 PMID: 24006081 PMCID: PMC3847770 SCOPUS ID: 2-s2.0-84888132259 09/06/2013       61 Citations
  • Rat Genome Database: a unique resource for rat, human, and mouse quantitative trait locus data. (Nigam R, Laulederkind SJ, Hayman GT, Smith JR, Wang SJ, Lowry TF, Petri V, De Pons J, Tutaj M, Liu W, Jayaraman P, Munzenmaier DH, Worthey EA, Dwinell MR, Shimoyama M, Jacob HJ) Physiol Genomics 2013 Sep 16;45(18):809-16 PMID: 23881287 PMCID: PMC3783816 SCOPUS ID: 2-s2.0-84884191657 07/25/2013       19 Citations
  • Analysis of disease-associated objects at the Rat Genome Database. (Wang SJ, Laulederkind SJ, Hayman GT, Smith JR, Petri V, Lowry TF, Nigam R, Dwinell MR, Worthey EA, Munzenmaier DH, Shimoyama M, Jacob HJ) Database (Oxford) 2013;2013:bat046 PMID: 23794737 PMCID: PMC3689439 SCOPUS ID: 2-s2.0-84885941569 06/26/2013       4 Citations
  • PhenoMiner: quantitative phenotype curation at the rat genome database. (Laulederkind SJ, Liu W, Smith JR, Hayman GT, Wang SJ, Nigam R, Petri V, Lowry TF, de Pons J, Dwinell MR, Shimoyama M) Database (Oxford) 2013;2013:bat015 PMID: 23603846 PMCID: PMC3630803 SCOPUS ID: 2-s2.0-84885154580 04/23/2013       19 Citations
  • Comparison of 2 rat breeding schemes using conventional caging. (Allen KP, Dwinell MR, Zappa A, Temple A, Thulin J) J Am Assoc Lab Anim Sci 2013 Mar;52(2):142-5 PMID: 23562096 PMCID: PMC3624781 04/09/2013       7 Citations
  • The Rat Genome Database 2013--data, tools and users. (Laulederkind SJ, Hayman GT, Wang SJ, Smith JR, Lowry TF, Nigam R, Petri V, de Pons J, Dwinell MR, Shimoyama M, Munzenmaier DH, Worthey EA, Jacob HJ) Brief Bioinform 2013 Jul;14(4):520-6 PMID: 23434633 PMCID: PMC3713714 SCOPUS ID: 2-s2.0-84888772878 02/26/2013       54 Citations
  • The updated RGD Pathway Portal utilizes increased curation efficiency and provides expanded pathway information. (Hayman GT, Jayaraman P, Petri V, Tutaj M, Liu W, De Pons J, Dwinell MR, Shimoyama M) Hum Genomics 2013 Feb 05;7:4 PMID: 23379628 PMCID: PMC3598722 SCOPUS ID: 2-s2.0-84878767208 02/06/2013       7 Citations
  • Exploring genetic, genomic, and phenotypic data at the rat genome database. (Laulederkind SJ, Hayman GT, Wang SJ, Lowry TF, Nigam R, Petri V, Smith JR, Dwinell MR, Jacob HJ, Shimoyama M) Curr Protoc Bioinformatics 2012 Dec;Chapter 1:Unit1.14 PMID: 23255149 PMCID: PMC3555435 SCOPUS ID: 2-s2.0-84875531338 12/21/2012       10 Citations
  • Chromosome substitution modulates resistance to ischemia reperfusion injury in Brown Norway rats. (Basile DP, Dwinell MR, Wang SJ, Shames BD, Donohoe DL, Chen S, Sreedharan R, Van Why SK) Kidney Int 2013 Feb;83(2):242-50 PMID: 23235564 PMCID: PMC3561482 SCOPUS ID: 2-s2.0-84873411495 12/14/2012       13 Citations
  • Gene Ontology annotations and resources. (Gene Ontology Consortium, Blake JA, Dolan M, Drabkin H, Hill DP, Li N, Sitnikov D, Bridges S, Burgess S, Buza T, McCarthy F, Peddinti D, Pillai L, Carbon S, Dietze H, Ireland A, Lewis SE, Mungall CJ, Gaudet P, Chrisholm RL, Fey P, Kibbe WA, Basu S, Siegele DA, McIntosh BK, Renfro DP, Zweifel AE, Hu JC, Brown NH, Tweedie S, Alam-Faruque Y, Apweiler R, Auchinchloss A, Axelsen K, Bely B, Blatter M-, Bonilla C, Bouguerleret L, Boutet E, Breuza L, Bridge A, Chan WM, Chavali G, Coudert E, Dimmer E, Estreicher A, Famiglietti L, Feuermann M, Gos A, Gruaz-Gumowski N, Hieta R, Hinz C, Hulo C, Huntley R, James J, Jungo F, Keller G, Laiho K, Legge D, Lemercier P, Lieberherr D, Magrane M, Martin MJ, Masson P, Mutowo-Muellenet P, O'Donovan C, Pedruzzi I, Pichler K, Poggioli D, Porras Millán P, Poux S, Rivoire C, Roechert B, Sawford T, Schneider M, Stutz A, Sundaram S, Tognolli M, Xenarios I, Foulgar R, Lomax J, Roncaglia P, Khodiyar VK, Lovering RC, Talmud PJ, Chibucos M, Giglio MG, Chang H-, Hunter S, McAnulla C, Mitchell A, Sangrador A, Stephan R, Harris MA, Oliver SG, Rutherford K, Wood V, Bahler J, Lock A, Kersey PJ, McDowall DM, Staines DM, Dwinell M, Shimoyama M, Laulederkind S, Hayman T, Wang S-, Petri V, Lowry T, D'Eustachio P, Matthews L, Balakrishnan R, Binkley G, Cherry JM, Costanzo MC, Dwight SS, Engel SR, Fisk DG, Hitz BC, Hong EL, Karra K, Miyasato SR, Nash RS, Park J, Skrzypek MS, Weng S, Wong ED, Berardini TZ, Huala E, Mi H, Thomas PD, Chan J, Kishore R, Sternberg P, Van Auken K, Howe D, Westerfield M) Nucleic Acids Res 2013 Jan;41(Database issue):D530-5 PMID: 23161678 PMCID: PMC3531070 SCOPUS ID: 2-s2.0-84874253819 11/20/2012       373 Citations
  • Three ontologies to define phenotype measurement data. (Shimoyama M, Nigam R, McIntosh LS, Nagarajan R, Rice T, Rao DC, Dwinell MR) Front Genet 2012;3:87 PMID: 22654893 PMCID: PMC3361058 SCOPUS ID: 2-s2.0-84869772444 06/02/2012    
  • Ontology searching and browsing at the Rat Genome Database. (Laulederkind SJ, Tutaj M, Shimoyama M, Hayman GT, Lowry TF, Nigam R, Petri V, Smith JR, Wang SJ, de Pons J, Dwinell MR, Jacob HJ) Database (Oxford) 2012;2012:bas016 PMID: 22434847 PMCID: PMC3308169 SCOPUS ID: 2-s2.0-84862262998 03/22/2012       17 Citations
  • The Gene Ontology: enhancements for 2011. (Gene Ontology Consortium) Nucleic Acids Res 2012 Jan;40(Database issue):D559-64 PMID: 22102568 PMCID: PMC3245151 SCOPUS ID: 2-s2.0-84859699831 11/22/2011       174 Citations
  • The emerging role for rat models in gene discovery. (Dwinell MR, Lazar J, Geurts AM) Mamm Genome 2011 Aug;22(7-8):466-75 PMID: 21732192 PMCID: PMC3643810 SCOPUS ID: 2-s2.0-80051552900 07/07/2011       23 Citations
  • The Rat Genome Database pathway portal. (Petri V, Shimoyama M, Hayman GT, Smith JR, Tutaj M, de Pons J, Dwinell MR, Munzenmaier DH, Twigger SN, Jacob HJ, RGD Team) Database (Oxford) 2011;2011:bar010 PMID: 21478484 PMCID: PMC3072770 SCOPUS ID: 2-s2.0-80052334281 04/12/2011       15 Citations
  • The Rat Genome Database curation tool suite: a set of optimized software tools enabling efficient acquisition, organization, and presentation of biological data. (Laulederkind SJ, Shimoyama M, Hayman GT, Lowry TF, Nigam R, Petri V, Smith JR, Wang SJ, de Pons J, Kowalski G, Liu W, Rood W, Munzenmaier DH, Dwinell MR, Twigger SN, Jacob HJ, RGD Team) Database (Oxford) 2011;2011:bar002 PMID: 21321022 PMCID: PMC3041158 SCOPUS ID: 2-s2.0-79956225148 02/16/2011       10 Citations
  • RGD: a comparative genomics platform. (Shimoyama M, Smith JR, Hayman T, Laulederkind S, Lowry T, Nigam R, Petri V, Wang SJ, Dwinell M, Jacob H, RGD Team) Hum Genomics 2011 Jan;5(2):124-9 PMID: 21296746 PMCID: PMC3222152 SCOPUS ID: 2-s2.0-79955839943 02/08/2011       23 Citations
  • Gene targeting in the rat: advances and opportunities. (Jacob HJ, Lazar J, Dwinell MR, Moreno C, Geurts AM) Trends Genet 2010 Dec;26(12):510-8 PMID: 20869786 PMCID: PMC2991520 SCOPUS ID: 2-s2.0-78549295495 09/28/2010       80 Citations
  • Vascular responses in aortic rings of a consomic rat panel derived from the Fawn Hooded Hypertensive strain. (Kunert MP, Dwinell MR, Lombard JH) Physiol Genomics 2010 Nov 29;42A(4):244-58 PMID: 20841496 PMCID: PMC3008365 SCOPUS ID: 2-s2.0-78649724378 09/16/2010       9 Citations
  • Postnatal ventilatory response to CO₂ in awake piglets. (Dwinell MR, Hogan GE, Sirlin E, Mayhew DL, Forster HV) Respir Physiol Neurobiol 2011 Jan 31;175(1):49-54 PMID: 20837167 SCOPUS ID: 2-s2.0-78650169346 09/15/2010    
  • Online tools for understanding rat physiology. (Dwinell MR) Brief Bioinform 2010 Jul;11(4):431-9 PMID: 20056729 PMCID: PMC2905522 SCOPUS ID: 2-s2.0-77955034237 01/09/2010       14 Citations
  • The rat genome database curators: who, what, where, why. (Shimoyama M, Hayman GT, Laulederkind SJ, Nigam R, Lowry TF, Petri V, Smith JR, Wang SJ, Munzenmaier DH, Dwinell MR, Twigger SN, Jacob HJ, RGD Team) PLoS Comput Biol 2009 Nov;5(11):e1000582 PMID: 19956751 PMCID: PMC2775909 SCOPUS ID: 2-s2.0-73449141822 12/04/2009       16 Citations
  • Differences between three inbred rat strains in number of K+ channel-immunoreactive neurons in the medullary raphé nucleus. (Riley D, Dwinell M, Qian B, Krause KL, Bonis JM, Neumueller S, Marshall BD, Hodges MR, Forster HV) J Appl Physiol (1985) 2010 Apr;108(4):1003-10 PMID: 19926827 PMCID: PMC2853200 SCOPUS ID: 2-s2.0-77950571666 11/21/2009       5 Citations
  • The Rat Genome Database 2009: variation, ontologies and pathways. (Dwinell MR, Worthey EA, Shimoyama M, Bakir-Gungor B, DePons J, Laulederkind S, Lowry T, Nigram R, Petri V, Smith J, Stoddard A, Twigger SN, Jacob HJ, RGD Team) Nucleic Acids Res 2009 Jan;37(Database issue):D744-9 PMID: 18996890 PMCID: PMC2686558 SCOPUS ID: 2-s2.0-58149194606 11/11/2008       59 Citations
  • Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease. (Mattson DL, Dwinell MR, Greene AS, Kwitek AE, Roman RJ, Jacob HJ, Cowley AW Jr) Am J Physiol Renal Physiol 2008 Sep;295(3):F837-42 PMID: 18653478 PMCID: PMC2536867 SCOPUS ID: 2-s2.0-54449084434 07/26/2008       76 Citations
  • Sex-specific differences in chromosome-dependent regulation of vascular reactivity in female consomic rat strains from a SSxBN cross. (Kunert MP, Dwinell MR, Drenjancevic Peric I, Lombard JH) Am J Physiol Regul Integr Comp Physiol 2008 Aug;295(2):R516-27 PMID: 18509103 PMCID: PMC2519925 SCOPUS ID: 2-s2.0-51149109894 05/30/2008       9 Citations
  • Physiological genomics: from bench to bedside. (Dwinell MR) Exp Physiol 2007 Nov;92(6):987 PMID: 17938419 SCOPUS ID: 2-s2.0-35248832526 10/17/2007    
  • Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats. (Mattson DL, Dwinell MR, Greene AS, Kwitek AE, Roman RJ, Cowley AW Jr, Jacob HJ) Am J Physiol Renal Physiol 2007 Dec;293(6):F1905-14 PMID: 17898042 SCOPUS ID: 2-s2.0-36549060031 09/28/2007       39 Citations
  • Postnatal developmental changes in CO2 sensitivity in rats. (Davis SE, Solhied G, Castillo M, Dwinell M, Brozoski D, Forster HV) J Appl Physiol (1985) 2006 Oct;101(4):1097-103 PMID: 16794027 SCOPUS ID: 2-s2.0-33749350208 06/24/2006       51 Citations
  • Consomic strategies to localize genomic regions related to vascular reactivity in the Dahl salt-sensitive rat. (Kunert MP, Drenjancevic-Peric I, Dwinell MR, Lombard JH, Cowley AW Jr, Greene AS, Kwitek AE, Jacob HJ) Physiol Genomics 2006 Aug 16;26(3):218-25 PMID: 16772359 SCOPUS ID: 2-s2.0-33747330104 06/15/2006       23 Citations
  • BN phenome: detailed characterization of the cardiovascular, renal, and pulmonary systems of the sequenced rat. (Kwitek AE, Jacob HJ, Baker JE, Dwinell MR, Forster HV, Greene AS, Kunert MP, Lombard JH, Mattson DL, Pritchard KA Jr, Roman RJ, Tonellato PJ, Cowley AW Jr) Physiol Genomics 2006 Apr 13;25(2):303-13 PMID: 16478827 SCOPUS ID: 2-s2.0-33645761913 02/16/2006       27 Citations
  • Genetic determinants on rat chromosome 6 modulate variation in the hypercapnic ventilatory response using consomic strains. (Dwinell MR, Forster HV, Petersen J, Rider A, Kunert MP, Cowley AW Jr, Jacob HJ) J Appl Physiol (1985) 2005 May;98(5):1630-8 PMID: 15661838 SCOPUS ID: 2-s2.0-17644403141 01/22/2005       13 Citations
  • Do genes on rat chromosomes 9, 13, 16, 18, and 20 contribute to regulation of breathing? (Forster HV, Dwinell MR, Hodges MR, Brozoski D, Hogan GE) Respir Physiol Neurobiol 2003 May 30;135(2-3):247-61 PMID: 12809624 SCOPUS ID: 2-s2.0-0038384573 06/18/2003       15 Citations
  • Ventilatory phenotypes among four strains of adult rats. (Hodges MR, Forster HV, Papanek PE, Dwinell MR, Hogan GE) J Appl Physiol (1985) 2002 Sep;93(3):974-83 PMID: 12183493 SCOPUS ID: 2-s2.0-0036707832 08/17/2002       48 Citations
  • Central amino acid neurotransmitters, ventilatory output and metabolism during acute hypoxia in anesthetized rats. (Dwinell MR, Kazemi H, Lam JT, Powell FL) Adv Exp Med Biol 2001;499:291-6 PMID: 11729894 SCOPUS ID: 2-s2.0-0035702427 12/04/2001       1 Citation
  • Ventilatory long-term facilitation in unanesthetized rats. (Olson EB Jr, Bohne CJ, Dwinell MR, Podolsky A, Vidruk EH, Fuller DD, Powell FL, Mitchel GS) J Appl Physiol (1985) 2001 Aug;91(2):709-16 PMID: 11457785 SCOPUS ID: 2-s2.0-0034923789 07/18/2001       114 Citations
  • Measuring ventilatory acclimatization to hypoxia: comparative aspects. (Powell FL, Dwinell MR, Aaron EA) Respir Physiol 2000 Sep;122(2-3):271-84 PMID: 10967350 SCOPUS ID: 2-s2.0-0034285080 09/01/2000       39 Citations
  • Central nervous system mechanisms of ventilatory acclimatization to hypoxia. (Powell FL, Huey KA, Dwinell MR) Respir Physiol 2000 Jul;121(2-3):223-36 PMID: 10963777 SCOPUS ID: 2-s2.0-0033837261 08/30/2000       64 Citations
  • Chronic hypoxia induces changes in the central nervous system processing of arterial chemoreceptor input. (Dwinell MR, Huey KA, Powell FL) Adv Exp Med Biol 2000;475:477-84 PMID: 10849688 SCOPUS ID: 2-s2.0-0034465921 06/13/2000       14 Citations
  • Chronic hypoxia enhances the phrenic nerve response to arterial chemoreceptor stimulation in anesthetized rats. (Dwinell MR, Powell FL) J Appl Physiol (1985) 1999 Aug;87(2):817-23 PMID: 10444644 SCOPUS ID: 2-s2.0-0032841030 08/13/1999       89 Citations
  • Differential respiratory muscle recruitment induced by clonidine in awake goats. (Hedrick MS, Dwinell MR, Janssen PL, Pizarro J, Bisgard GE) J Appl Physiol (1985) 1998 Apr;84(4):1198-207 PMID: 9516185 SCOPUS ID: 2-s2.0-0031944642 05/09/1998       17 Citations
  • Central dopamine D2 receptors in the CNS are not involved in ventilatory acclimatization to hypoxia in anesthetized rats (Dwinell MR, Powell FL) FASEB Journal 20 March 1998;12(5) SCOPUS ID: 2-s2.0-33749219526 03/20/1998    
  • The role of D2-dopamine receptors in ventilatory acclimatization to chronic hypoxia in mice (Huey KA, Szewczak J, Dwinell MR, Juarez RA, Low MJ, Powell FL) FASEB Journal 20 March 1998;12(5) SCOPUS ID: 2-s2.0-23544469596 03/20/1998    
  • Intracarotid dopamine infusion does not prevent acclimatization to hypoxia. (Janssen PL, Dwinell MR, Pizarro J, Bisgard GE) Respir Physiol 1998 Jan;111(1):33-43 PMID: 9496470 SCOPUS ID: 2-s2.0-0031963147 03/13/1998       12 Citations
  • Carotid body dopaminergic mechanisms are functional after acclimatization to hypoxia in goats. (Janssen PL, O'Halloran KD, Pizarro J, Dwinell MR, Bisgard GE) Respir Physiol 1998 Jan;111(1):25-32 PMID: 9496469 SCOPUS ID: 2-s2.0-0031963774 03/13/1998       20 Citations
  • Lack of long-term facilitation of ventilation after exposure to hypoxia in goats. (Dwinell MR, Janssen PL, Bisgard GE) Respir Physiol 1997 Apr;108(1):1-9 PMID: 9178372 SCOPUS ID: 2-s2.0-0030920213 04/01/1997       31 Citations
  • Effects of carotid body hypocapnia during ventilatory acclimatization to hypoxia. (Dwinell MR, Janssen PL, Pizarro J, Bisgard GE) J Appl Physiol (1985) 1997 Jan;82(1):118-24 PMID: 9029206 SCOPUS ID: 2-s2.0-0031019367 01/01/1997       13 Citations
  • Increased carotid body CO2 sensitivity after ventilatory acclimatization to hypoxia in goats (Dwinell MR, Janssen PL, Pizarro J, Bisgard GE) FASEB Journal 1996;10(3) SCOPUS ID: 2-s2.0-33749184060 12/01/1996    
  • The role of carotid body CO2 during ventilatory acclimatization to hypoxia in the goat. (Dwinell MR, Janssen PL, Pizarro J, Bisgard GE) Adv Exp Med Biol 1996;410:387-90 PMID: 9030330 SCOPUS ID: 2-s2.0-0030482048 01/01/1996       1 Citation
  • Effects of continuous intracarotid infusion of dopamine during long-term hypoxia in awake goats. (Janssen PL, Dwinell MR, Pizarro DJ, Bisgard GE) Adv Exp Med Biol 1996;410:383-6 PMID: 9030329 SCOPUS ID: 2-s2.0-0030477465 01/01/1996       2 Citations
  • Mitochondrial division, blood vessel dilation, and large intercellular space expansion of goat carotid body during hypoxia. (Xue D, Keith IM, Dwinell MR, Bisgard GE) Adv Exp Med Biol 1996;410:55-8 PMID: 9030276 SCOPUS ID: 2-s2.0-0030451660 01/01/1996       1 Citation
  • Recurrent laryngeal nerve activation by alpha 2 adrenergic agonists in goats. (Hedrick MS, Ryan ML, Bisgard GE) Respir Physiol 1995 Aug;101(2):129-37 PMID: 8570915 08/01/1995       15 Citations
  • Intracarotid substance P infusion inhibits ventilation in the goat. (Pizarro J, Ryan ML, Hedrick MS, Xue DH, Keith IM, Bisgard GE) Respir Physiol 1995 Jul;101(1):11-22 PMID: 8525117 07/01/1995       13 Citations
  • Effects of carotid body sympathetic denervation on ventilatory acclimatization to hypoxia in the goat. (Ryan ML, Hedrick MS, Pizarro J, Bisgard GE) Respir Physiol 1995 Feb;99(2):215-24 PMID: 7777704 02/01/1995       13 Citations
  • Modulation of respiratory rhythm by alpha 2-adrenoceptors in awake and anesthetized goats. (Hedrick MS, Ryan ML, Pizarro J, Bisgard GE) J Appl Physiol (1985) 1994 Aug;77(2):742-50 PMID: 8002523 08/01/1994       27 Citations
  • Substance P inhibits ventilation in the goat. (Bisgard GE, Pizarro J, Ryan M, Hedrick M) Adv Exp Med Biol 1994;360:277-9 PMID: 7532902 01/01/1994       1 Citation
  • Carotid body noradrenergic sensitivity in ventilatory acclimatization to hypoxia. (Ryan ML, Hedrick MS, Pizarro J, Bisgard GE) Respir Physiol 1993 Apr;92(1):77-90 PMID: 8390087 04/01/1993       23 Citations
  • Intracarotid norepinephrine infusions inhibit ventilation in goats. (Pizarro J, Warner MM, Ryan M, Mitchell GS, Bisgard GE) Respir Physiol 1992 Dec;90(3):299-310 PMID: 1480841 12/01/1992       20 Citations
  • Last update: 11/15/2020
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