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Melinda R. Dwinell PhD

Melinda R. Dwinell PhD

Center Associate Director, Associate Professor

Institution: Medical College of Wisconsin
Department: Physiology
Program: Genetics

Member of the Cancer Center
Member of the Cardiovascular Center
Member of the Genomic Sciences and Precision Medicine Center (GSPMC)


Research Experience

  • Cardiovascular Physiological Phenomena
  • Circulatory and Respiratory Physiological Phenomena
  • Phenotype
  • Respiratory Physiological Phenomena
  • Methodologies and Techniques

  • Airway Resistance
  • Monitoring, Physiologic
  • Plethysmography, Whole Body
  • MCW Program / Core Facilities

  • Rat Research Models Service Center
  • Publications

  • The Gene Ontology Resource: 20 years and still GOing strong. (The Gene Ontology Consortium) Nucleic Acids Res 2018 11 05 PMID: 30395331 11/06/2018    
  • Sdha+/- Rats Display Minimal Muscle Pathology Without Significant Behavioral or Biochemical Abnormalities. (Siebers EM, Choi MJ, Tinklenberg JA, Beatka MJ, Ayres S, Meng H, Helbling DC, Takizawa A, Bennett B, Garces AM, Dias Duarte Machado LG, Dimmock D, Dwinell MR, Geurts AM, Lawlor MW) J Neuropathol Exp Neurol 2018 Aug 01;77(8):665-672 PMID: 29850869 PMCID: PMC6044411 06/01/2018    
  • A Primer for the Rat Genome Database (RGD). (Laulederkind SJF, Hayman GT, Wang SJ, Smith JR, Petri V, Hoffman MJ, De Pons J, Tutaj MA, Ghiasvand O, Tutaj M, Thota J, Dwinell MR, Shimoyama M) Methods Mol Biol 2018;1757:163-209 PMID: 29761460 05/16/2018    
  • Rat Genome and Model Resources. (Shimoyama M, Smith JR, Bryda E, Kuramoto T, Saba L, Dwinell M) ILAR J 2017 07 01;58(1):42-58 PMID: 28838068 PMCID: PMC6057551 08/26/2017       3 Citations
  • Haploid embryonic stem cell lines derived from androgenetic and parthenogenetic rat blastocysts. (Hirabayashi M, Hara H, Goto T, Takizawa A, Dwinell MR, Yamanaka T, Hochi S, Nakauchi H) J Reprod Dev 2017 Dec 15;63(6):611-616 PMID: 28824040 PMCID: PMC5735273 08/22/2017    
  • Host genetic modifiers of nonproductive angiogenesis inhibit breast cancer. (Flister MJ, Tsaih SW, Stoddard A, Plasterer C, Jagtap J, Parchur AK, Sharma G, Prisco AR, Lemke A, Murphy D, Al-Gizawiy M, Straza M, Ran S, Geurts AM, Dwinell MR, Greene AS, Bergom C, LaViolette PS, Joshi A) Breast Cancer Res Treat 2017 Aug;165(1):53-64 PMID: 28567545 06/02/2017       2 Citations
  • Lung injury pathways: Adenosine receptor 2B signaling limits development of ischemic bronchiolitis obliterans organizing pneumonia. (Densmore JC, Schaid TR, Jeziorczak PM, Medhora M, Audi S, Nayak S, Auchampach J, Dwinell MR, Geurts AM, Jacobs ER) Exp Lung Res 2017 02;43(1):38-48 PMID: 28266889 PMCID: PMC5831175 03/08/2017       3 Citations
  • Exploring human disease using the Rat Genome Database. (Shimoyama M, Laulederkind SJ, De Pons J, Nigam R, Smith JR, Tutaj M, Petri V, Hayman GT, Wang SJ, Ghiasvand O, Thota J, Dwinell MR) Dis Model Mech 2016 10 01;9(10):1089-1095 PMID: 27736745 PMCID: PMC5087824 10/14/2016       7 Citations
  • Disease, Models, Variants and Altered Pathways-Journeying RGD Through the Magnifying Glass. (Petri V, Hayman GT, Tutaj M, Smith JR, Laulederkind S, Wang SJ, Nigam R, De Pons J, Shimoyama M, Dwinell MR) Comput Struct Biotechnol J 2016;14:35-48 PMID: 27602200 PMCID: PMC4700298 09/08/2016    
  • Comprehensive coverage of cardiovascular disease data in the disease portals at the Rat Genome Database. (Wang SJ, Laulederkind SJ, Hayman GT, Petri V, Smith JR, Tutaj M, Nigam R, Dwinell MR, Shimoyama M) Physiol Genomics 2016 08 01;48(8):589-600 PMID: 27287925 PMCID: PMC5005459 06/12/2016       1 Citations
  • The Disease Portals, disease-gene annotation and the RGD disease ontology at the Rat Genome Database. (Hayman GT, Laulederkind SJ, Smith JR, Wang SJ, Petri V, Nigam R, Tutaj M, De Pons J, Dwinell MR, Shimoyama M) Database (Oxford) 2016;2016 PMID: 27009807 PMCID: PMC4805243 03/25/2016       7 Citations
  • Report of the National Heart, Lung, and Blood Institute Working Group on Sex Differences Research in Cardiovascular Disease: Scientific Questions and Challenges. (Maric-Bilkan C, Arnold AP, Taylor DA, Dwinell M, Howlett SE, Wenger N, Reckelhoff JF, Sandberg K, Churchill G, Levin E, Lundberg MS) Hypertension 2016 May;67(5):802-7 PMID: 26975706 PMCID: PMC4833564 03/16/2016       19 Citations
  • Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease. (Rubattu S, Di Castro S, Schulz H, Geurts AM, Cotugno M, Bianchi F, Maatz H, Hummel O, Falak S, Stanzione R, Marchitti S, Scarpino S, Giusti B, Kura A, Gensini GF, Peyvandi F, Mannucci PM, Rasura M, Sciarretta S, Dwinell MR, Hubner N, Volpe M) J Am Heart Assoc 2016 Feb 17;5(2) PMID: 26888427 PMCID: PMC4802485 02/19/2016    
  • The phenotypic impact of the male-specific region of chromosome-Y in inbred mating: the role of genetic variants and gene duplications in multiple inbred rat strains. (Prokop JW, Tsaih SW, Faber AB, Boehme S, Underwood AC, Troyer S, Playl L, Milsted A, Turner ME, Ely D, Martins AS, Tutaj M, Lazar J, Dwinell MR, Jacob HJ) Biol Sex Differ 2016;7:10 PMID: 26848384 PMCID: PMC4740989 02/06/2016    
  • Rat Breeding Parameters According to Floor Space Available in Cage. (Allen KP, Dwinell MR, Zappa AM, Michaels AM, Murray KM, Thulin JD) J Am Assoc Lab Anim Sci 2016 Jan;55(1):21-4 PMID: 26817975 PMCID: PMC4747006 01/29/2016       1 Citations
  • Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension. (Nayak S, Khan MA, Wan TC, Pei H, Linden J, Dwinell MR, Geurts AM, Imig JD, Auchampach JA) Purinergic Signal 2015 Dec;11(4):519-31 PMID: 26385692 PMCID: PMC4648794 09/20/2015       5 Citations
  • 2015 Guidelines for Establishing Genetically Modified Rat Models for Cardiovascular Research. (Flister MJ, Prokop JW, Lazar J, Shimoyama M, Dwinell M, Geurts A, International Committee on Standardized Genetic Nomenclature for Mice, Rat Genome and Nomenclature Committee) J Cardiovasc Transl Res 2015 Jun;8(4):269-77 PMID: 25920443 PMCID: PMC4475456 04/30/2015       8 Citations
  • PhenoMiner: a quantitative phenotype database for the laboratory rat, Rattus norvegicus. Application in hypertension and renal disease. (Wang SJ, Laulederkind SJ, Hayman GT, Petri V, Liu W, Smith JR, Nigam R, Dwinell MR, Shimoyama M) Database (Oxford) 2015;2015 PMID: 25632109 PMCID: PMC4309021 01/30/2015       5 Citations
  • OntoMate: a text-mining tool aiding curation at the Rat Genome Database. (Liu W, Laulederkind SJ, Hayman GT, Wang SJ, Nigam R, Smith JR, De Pons J, Dwinell MR, Shimoyama M) Database (Oxford) 2015;2015 PMID: 25619558 PMCID: PMC4305386 01/27/2015       7 Citations
  • Gene Ontology Consortium: going forward. (Gene Ontology Consortium) Nucleic Acids Res 2015 Jan;43(Database issue):D1049-56 PMID: 25428369 PMCID: PMC4383973 11/28/2014       1056 Citations
  • Enhancement of resting-state fcMRI networks by prior sensory stimulation. (Li C, Li Z, Ward BD, Dwinell MR, Lombard JH, Hudetz AG, Pawela CP) Brain Connect 2014 Nov;4(9):760-8 PMID: 25387238 PMCID: PMC4238242 11/12/2014       3 Citations
  • The Rat Genome Database 2015: genomic, phenotypic and environmental variations and disease. (Shimoyama M, De Pons J, Hayman GT, Laulederkind SJ, Liu W, Nigam R, Petri V, Smith JR, Tutaj M, Wang SJ, Worthey E, Dwinell M, Jacob H) Nucleic Acids Res 2015 Jan;43(Database issue):D743-50 PMID: 25355511 PMCID: PMC4383884 10/31/2014       88 Citations
  • Disease pathways at the Rat Genome Database Pathway Portal: genes in context-a network approach to understanding the molecular mechanisms of disease. (Petri V, Hayman GT, Tutaj M, Smith JR, Laulederkind SJ, Wang SJ, Nigam R, De Pons J, Shimoyama M, Dwinell MR, Worthey EA, Jacob HJ) Hum Genomics 2014 Sep 30;8:17 PMID: 25265995 PMCID: PMC4191248 10/01/2014       5 Citations
  • The pathway ontology - updates and applications. (Petri V, Jayaraman P, Tutaj M, Hayman GT, Smith JR, De Pons J, Laulederkind SJ, Lowry TF, Nigam R, Wang SJ, Shimoyama M, Dwinell MR, Munzenmaier DH, Worthey EA, Jacob HJ) J Biomed Semantics 2014 Feb 05;5(1):7 PMID: 24499703 PMCID: PMC3922094 02/07/2014    
  • Amelioration of salt-induced vascular dysfunction in mesenteric arteries of Dahl salt-sensitive rats by missense mutation of extracellular superoxide dismutase. (Beyer AM, Raffai G, Weinberg BD, Fredrich K, Rodgers MS, Geurts AM, Jacob HJ, Dwinell MR, Lombard JH) Am J Physiol Heart Circ Physiol 2014 Feb;306(3):H339-47 PMID: 24322611 PMCID: PMC3920146 12/11/2013       4 Citations
  • Rat Strain Ontology: structured controlled vocabulary designed to facilitate access to strain data at RGD. (Nigam R, Munzenmaier DH, Worthey EA, Dwinell MR, Shimoyama M, Jacob HJ) J Biomed Semantics 2013 Nov 22;4(1):36 PMID: 24267899 PMCID: PMC4177145 11/26/2013    
  • The clinical measurement, measurement method and experimental condition ontologies: expansion, improvements and new applications. (Smith JR, Park CA, Nigam R, Laulederkind SJ, Hayman GT, Wang SJ, Lowry TF, Petri V, Pons JD, Tutaj M, Liu W, Worthey EA, Shimoyama M, Dwinell MR) J Biomed Semantics 2013 Oct 08;4(1):26 PMID: 24103152 PMCID: PMC3882879 10/10/2013    
  • FMRI and fcMRI phenotypes map the genomic effect of chromosome 13 in Brown Norway and Dahl salt-sensitive rats. (Li Z, Ward BD, Dwinell MR, Lombard JH, Pawela CP) Neuroimage 2014 Apr 15;90:403-12 PMID: 24084065 10/03/2013       1 Citations
  • Identifying multiple causative genes at a single GWAS locus. (Flister MJ, Tsaih SW, O'Meara CC, Endres B, Hoffman MJ, Geurts AM, Dwinell MR, Lazar J, Jacob HJ, Moreno C) Genome Res 2013 Dec;23(12):1996-2002 PMID: 24006081 PMCID: PMC3847770 09/06/2013       46 Citations
  • Rat Genome Database: a unique resource for rat, human, and mouse quantitative trait locus data. (Nigam R, Laulederkind SJ, Hayman GT, Smith JR, Wang SJ, Lowry TF, Petri V, De Pons J, Tutaj M, Liu W, Jayaraman P, Munzenmaier DH, Worthey EA, Dwinell MR, Shimoyama M, Jacob HJ) Physiol Genomics 2013 Sep 16;45(18):809-16 PMID: 23881287 PMCID: PMC3783816 07/25/2013       16 Citations
  • Analysis of disease-associated objects at the Rat Genome Database. (Wang SJ, Laulederkind SJ, Hayman GT, Smith JR, Petri V, Lowry TF, Nigam R, Dwinell MR, Worthey EA, Munzenmaier DH, Shimoyama M, Jacob HJ) Database (Oxford) 2013;2013:bat046 PMID: 23794737 PMCID: PMC3689439 06/26/2013       3 Citations
  • PhenoMiner: quantitative phenotype curation at the rat genome database. (Laulederkind SJ, Liu W, Smith JR, Hayman GT, Wang SJ, Nigam R, Petri V, Lowry TF, de Pons J, Dwinell MR, Shimoyama M) Database (Oxford) 2013;2013:bat015 PMID: 23603846 PMCID: PMC3630803 04/23/2013       14 Citations
  • Comparison of 2 rat breeding schemes using conventional caging. (Allen KP, Dwinell MR, Zappa A, Temple A, Thulin J) J Am Assoc Lab Anim Sci 2013 Mar;52(2):142-5 PMID: 23562096 PMCID: PMC3624781 04/09/2013       2 Citations
  • The Rat Genome Database 2013--data, tools and users. (Laulederkind SJ, Hayman GT, Wang SJ, Smith JR, Lowry TF, Nigam R, Petri V, de Pons J, Dwinell MR, Shimoyama M, Munzenmaier DH, Worthey EA, Jacob HJ) Brief Bioinform 2013 Jul;14(4):520-6 PMID: 23434633 PMCID: PMC3713714 02/26/2013       53 Citations
  • The updated RGD Pathway Portal utilizes increased curation efficiency and provides expanded pathway information. (Hayman GT, Jayaraman P, Petri V, Tutaj M, Liu W, De Pons J, Dwinell MR, Shimoyama M) Hum Genomics 2013 Feb 05;7:4 PMID: 23379628 PMCID: PMC3598722 02/06/2013       7 Citations
  • Exploring genetic, genomic, and phenotypic data at the rat genome database. (Laulederkind SJ, Hayman GT, Wang SJ, Lowry TF, Nigam R, Petri V, Smith JR, Dwinell MR, Jacob HJ, Shimoyama M) Curr Protoc Bioinformatics 2012 Dec;Chapter 1:Unit1.14 PMID: 23255149 PMCID: PMC3555435 12/21/2012       10 Citations
  • Chromosome substitution modulates resistance to ischemia reperfusion injury in Brown Norway rats. (Basile DP, Dwinell MR, Wang SJ, Shames BD, Donohoe DL, Chen S, Sreedharan R, Van Why SK) Kidney Int 2013 Feb;83(2):242-50 PMID: 23235564 PMCID: PMC3561482 12/14/2012       9 Citations
  • Gene Ontology annotations and resources. (Gene Ontology Consortium, Blake JA, Dolan M, Drabkin H, Hill DP, Li N, Sitnikov D, Bridges S, Burgess S, Buza T, McCarthy F, Peddinti D, Pillai L, Carbon S, Dietze H, Ireland A, Lewis SE, Mungall CJ, Gaudet P, Chrisholm RL, Fey P, Kibbe WA, Basu S, Siegele DA, McIntosh BK, Renfro DP, Zweifel AE, Hu JC, Brown NH, Tweedie S, Alam-Faruque Y, Apweiler R, Auchinchloss A, Axelsen K, Bely B, Blatter M-, Bonilla C, Bouguerleret L, Boutet E, Breuza L, Bridge A, Chan WM, Chavali G, Coudert E, Dimmer E, Estreicher A, Famiglietti L, Feuermann M, Gos A, Gruaz-Gumowski N, Hieta R, Hinz C, Hulo C, Huntley R, James J, Jungo F, Keller G, Laiho K, Legge D, Lemercier P, Lieberherr D, Magrane M, Martin MJ, Masson P, Mutowo-Muellenet P, O'Donovan C, Pedruzzi I, Pichler K, Poggioli D, Porras Millán P, Poux S, Rivoire C, Roechert B, Sawford T, Schneider M, Stutz A, Sundaram S, Tognolli M, Xenarios I, Foulgar R, Lomax J, Roncaglia P, Khodiyar VK, Lovering RC, Talmud PJ, Chibucos M, Giglio MG, Chang H-, Hunter S, McAnulla C, Mitchell A, Sangrador A, Stephan R, Harris MA, Oliver SG, Rutherford K, Wood V, Bahler J, Lock A, Kersey PJ, McDowall DM, Staines DM, Dwinell M, Shimoyama M, Laulederkind S, Hayman T, Wang S-, Petri V, Lowry T, D'Eustachio P, Matthews L, Balakrishnan R, Binkley G, Cherry JM, Costanzo MC, Dwight SS, Engel SR, Fisk DG, Hitz BC, Hong EL, Karra K, Miyasato SR, Nash RS, Park J, Skrzypek MS, Weng S, Wong ED, Berardini TZ, Huala E, Mi H, Thomas PD, Chan J, Kishore R, Sternberg P, Van Auken K, Howe D, Westerfield M) Nucleic Acids Res 2013 Jan;41(Database issue):D530-5 PMID: 23161678 PMCID: PMC3531070 11/20/2012       318 Citations
  • Three ontologies to define phenotype measurement data. (Shimoyama M, Nigam R, McIntosh LS, Nagarajan R, Rice T, Rao DC, Dwinell MR) Front Genet 2012;3:87 PMID: 22654893 PMCID: PMC3361058 06/02/2012    
  • Ontology searching and browsing at the Rat Genome Database. (Laulederkind SJ, Tutaj M, Shimoyama M, Hayman GT, Lowry TF, Nigam R, Petri V, Smith JR, Wang SJ, de Pons J, Dwinell MR, Jacob HJ) Database (Oxford) 2012;2012:bas016 PMID: 22434847 PMCID: PMC3308169 03/22/2012       14 Citations
  • The Gene Ontology: enhancements for 2011. (Gene Ontology Consortium) Nucleic Acids Res 2012 Jan;40(Database issue):D559-64 PMID: 22102568 PMCID: PMC3245151 11/22/2011       163 Citations
  • The emerging role for rat models in gene discovery. (Dwinell MR, Lazar J, Geurts AM) Mamm Genome 2011 Aug;22(7-8):466-75 PMID: 21732192 PMCID: PMC3643810 07/07/2011       19 Citations
  • The Rat Genome Database pathway portal. (Petri V, Shimoyama M, Hayman GT, Smith JR, Tutaj M, de Pons J, Dwinell MR, Munzenmaier DH, Twigger SN, Jacob HJ, RGD Team) Database (Oxford) 2011;2011:bar010 PMID: 21478484 PMCID: PMC3072770 04/12/2011       13 Citations
  • The Rat Genome Database curation tool suite: a set of optimized software tools enabling efficient acquisition, organization, and presentation of biological data. (Laulederkind SJ, Shimoyama M, Hayman GT, Lowry TF, Nigam R, Petri V, Smith JR, Wang SJ, de Pons J, Kowalski G, Liu W, Rood W, Munzenmaier DH, Dwinell MR, Twigger SN, Jacob HJ, RGD Team) Database (Oxford) 2011;2011:bar002 PMID: 21321022 PMCID: PMC3041158 02/16/2011       10 Citations
  • Gene targeting in the rat: advances and opportunities. (Jacob HJ, Lazar J, Dwinell MR, Moreno C, Geurts AM) Trends Genet 2010 Dec;26(12):510-8 PMID: 20869786 PMCID: PMC2991520 09/28/2010       75 Citations
  • Vascular responses in aortic rings of a consomic rat panel derived from the Fawn Hooded Hypertensive strain. (Kunert MP, Dwinell MR, Lombard JH) Physiol Genomics 2010 Nov 29;42A(4):244-58 PMID: 20841496 PMCID: PMC3008365 09/16/2010       8 Citations
  • Postnatal ventilatory response to CO₂ in awake piglets. (Dwinell MR, Hogan GE, Sirlin E, Mayhew DL, Forster HV) Respir Physiol Neurobiol 2011 Jan 31;175(1):49-54 PMID: 20837167 09/15/2010    
  • Online tools for understanding rat physiology. (Dwinell MR) Brief Bioinform 2010 Jul;11(4):431-9 PMID: 20056729 PMCID: PMC2905522 01/09/2010       10 Citations
  • The rat genome database curators: who, what, where, why. (Shimoyama M, Hayman GT, Laulederkind SJ, Nigam R, Lowry TF, Petri V, Smith JR, Wang SJ, Munzenmaier DH, Dwinell MR, Twigger SN, Jacob HJ, RGD Team) PLoS Comput Biol 2009 Nov;5(11):e1000582 PMID: 19956751 PMCID: PMC2775909 12/04/2009       14 Citations
  • Differences between three inbred rat strains in number of K+ channel-immunoreactive neurons in the medullary raphé nucleus. (Riley D, Dwinell M, Qian B, Krause KL, Bonis JM, Neumueller S, Marshall BD, Hodges MR, Forster HV) J Appl Physiol (1985) 2010 Apr;108(4):1003-10 PMID: 19926827 PMCID: PMC2853200 11/21/2009       5 Citations
  • The Rat Genome Database 2009: variation, ontologies and pathways. (Dwinell MR, Worthey EA, Shimoyama M, Bakir-Gungor B, DePons J, Laulederkind S, Lowry T, Nigram R, Petri V, Smith J, Stoddard A, Twigger SN, Jacob HJ, RGD Team) Nucleic Acids Res 2009 Jan;37(Database issue):D744-9 PMID: 18996890 PMCID: PMC2686558 11/11/2008       54 Citations
  • Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease. (Mattson DL, Dwinell MR, Greene AS, Kwitek AE, Roman RJ, Jacob HJ, Cowley AW Jr) Am J Physiol Renal Physiol 2008 Sep;295(3):F837-42 PMID: 18653478 PMCID: PMC2536867 07/26/2008       64 Citations
  • Sex-specific differences in chromosome-dependent regulation of vascular reactivity in female consomic rat strains from a SSxBN cross. (Kunert MP, Dwinell MR, Drenjancevic Peric I, Lombard JH) Am J Physiol Regul Integr Comp Physiol 2008 Aug;295(2):R516-27 PMID: 18509103 PMCID: PMC2519925 05/30/2008       7 Citations
  • Physiological genomics: from bench to bedside. (Dwinell MR) Exp Physiol 2007 Nov;92(6):987 PMID: 17938419 10/17/2007    
  • Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats. (Mattson DL, Dwinell MR, Greene AS, Kwitek AE, Roman RJ, Cowley AW Jr, Jacob HJ) Am J Physiol Renal Physiol 2007 Dec;293(6):F1905-14 PMID: 17898042 09/28/2007       37 Citations
  • Postnatal developmental changes in CO2 sensitivity in rats. (Davis SE, Solhied G, Castillo M, Dwinell M, Brozoski D, Forster HV) J Appl Physiol (1985) 2006 Oct;101(4):1097-103 PMID: 16794027 06/24/2006       44 Citations
  • Consomic strategies to localize genomic regions related to vascular reactivity in the Dahl salt-sensitive rat. (Kunert MP, Drenjancevic-Peric I, Dwinell MR, Lombard JH, Cowley AW Jr, Greene AS, Kwitek AE, Jacob HJ) Physiol Genomics 2006 Aug 16;26(3):218-25 PMID: 16772359 06/15/2006       20 Citations
  • BN phenome: detailed characterization of the cardiovascular, renal, and pulmonary systems of the sequenced rat. (Kwitek AE, Jacob HJ, Baker JE, Dwinell MR, Forster HV, Greene AS, Kunert MP, Lombard JH, Mattson DL, Pritchard KA Jr, Roman RJ, Tonellato PJ, Cowley AW Jr) Physiol Genomics 2006 Apr 13;25(2):303-13 PMID: 16478827 02/16/2006       26 Citations
  • Genetic determinants on rat chromosome 6 modulate variation in the hypercapnic ventilatory response using consomic strains. (Dwinell MR, Forster HV, Petersen J, Rider A, Kunert MP, Cowley AW Jr, Jacob HJ) J Appl Physiol (1985) 2005 May;98(5):1630-8 PMID: 15661838 01/22/2005       13 Citations
  • Do genes on rat chromosomes 9, 13, 16, 18, and 20 contribute to regulation of breathing? (Forster HV, Dwinell MR, Hodges MR, Brozoski D, Hogan GE) Respir Physiol Neurobiol 2003 May 30;135(2-3):247-61 PMID: 12809624 06/18/2003       15 Citations
  • Ventilatory phenotypes among four strains of adult rats. (Hodges MR, Forster HV, Papanek PE, Dwinell MR, Hogan GE) J Appl Physiol (1985) 2002 Sep;93(3):974-83 PMID: 12183493 08/17/2002       43 Citations
  • Central amino acid neurotransmitters, ventilatory output and metabolism during acute hypoxia in anesthetized rats. (Dwinell MR, Kazemi H, Lam JT, Powell FL) Adv Exp Med Biol 2001;499:291-6 PMID: 11729894 12/04/2001       1 Citations
  • Ventilatory long-term facilitation in unanesthetized rats. (Olson EB Jr, Bohne CJ, Dwinell MR, Podolsky A, Vidruk EH, Fuller DD, Powell FL, Mitchel GS) J Appl Physiol (1985) 2001 Aug;91(2):709-16 PMID: 11457785 07/18/2001       111 Citations
  • Measuring ventilatory acclimatization to hypoxia: comparative aspects. (Powell FL, Dwinell MR, Aaron EA) Respir Physiol 2000 Sep;122(2-3):271-84 PMID: 10967350 09/01/2000       37 Citations
  • Central nervous system mechanisms of ventilatory acclimatization to hypoxia. (Powell FL, Huey KA, Dwinell MR) Respir Physiol 2000 Jul;121(2-3):223-36 PMID: 10963777 08/30/2000       57 Citations
  • Chronic hypoxia induces changes in the central nervous system processing of arterial chemoreceptor input. (Dwinell MR, Huey KA, Powell FL) Adv Exp Med Biol 2000;475:477-84 PMID: 10849688 06/13/2000       14 Citations
  • Chronic hypoxia enhances the phrenic nerve response to arterial chemoreceptor stimulation in anesthetized rats. (Dwinell MR, Powell FL) J Appl Physiol (1985) 1999 Aug;87(2):817-23 PMID: 10444644 08/13/1999       83 Citations
  • Differential respiratory muscle recruitment induced by clonidine in awake goats. (Hedrick MS, Dwinell MR, Janssen PL, Pizarro J, Bisgard GE) J Appl Physiol (1985) 1998 Apr;84(4):1198-207 PMID: 9516185 05/09/1998       17 Citations
  • Intracarotid dopamine infusion does not prevent acclimatization to hypoxia. (Janssen PL, Dwinell MR, Pizarro J, Bisgard GE) Respir Physiol 1998 Jan;111(1):33-43 PMID: 9496470 03/13/1998       11 Citations
  • Carotid body dopaminergic mechanisms are functional after acclimatization to hypoxia in goats. (Janssen PL, O'Halloran KD, Pizarro J, Dwinell MR, Bisgard GE) Respir Physiol 1998 Jan;111(1):25-32 PMID: 9496469 03/13/1998       19 Citations
  • Lack of long-term facilitation of ventilation after exposure to hypoxia in goats. (Dwinell MR, Janssen PL, Bisgard GE) Respir Physiol 1997 Apr;108(1):1-9 PMID: 9178372 04/01/1997       31 Citations
  • Effects of carotid body hypocapnia during ventilatory acclimatization to hypoxia. (Dwinell MR, Janssen PL, Pizarro J, Bisgard GE) J Appl Physiol (1985) 1997 Jan;82(1):118-24 PMID: 9029206 01/01/1997       13 Citations
  • Mitochondrial division, blood vessel dilation, and large intercellular space expansion of goat carotid body during hypoxia. (Xue D, Keith IM, Dwinell MR, Bisgard GE) Adv Exp Med Biol 1996;410:55-8 PMID: 9030276 01/01/1996       1 Citations
  • Effects of continuous intracarotid infusion of dopamine during long-term hypoxia in awake goats. (Janssen PL, Dwinell MR, Pizarro DJ, Bisgard GE) Adv Exp Med Biol 1996;410:383-6 PMID: 9030329 01/01/1996       2 Citations
  • The role of carotid body CO2 during ventilatory acclimatization to hypoxia in the goat. (Dwinell MR, Janssen PL, Pizarro J, Bisgard GE) Adv Exp Med Biol 1996;410:387-90 PMID: 9030330 01/01/1996       1 Citations
  • Recurrent laryngeal nerve activation by alpha 2 adrenergic agonists in goats. (Hedrick MS, Ryan ML, Bisgard GE) Respir Physiol 1995 Aug;101(2):129-37 PMID: 8570915 08/01/1995       15 Citations
  • Intracarotid substance P infusion inhibits ventilation in the goat. (Pizarro J, Ryan ML, Hedrick MS, Xue DH, Keith IM, Bisgard GE) Respir Physiol 1995 Jul;101(1):11-22 PMID: 8525117 07/01/1995       12 Citations
  • Effects of carotid body sympathetic denervation on ventilatory acclimatization to hypoxia in the goat. (Ryan ML, Hedrick MS, Pizarro J, Bisgard GE) Respir Physiol 1995 Feb;99(2):215-24 PMID: 7777704 02/01/1995       12 Citations
  • Modulation of respiratory rhythm by alpha 2-adrenoceptors in awake and anesthetized goats. (Hedrick MS, Ryan ML, Pizarro J, Bisgard GE) J Appl Physiol (1985) 1994 Aug;77(2):742-50 PMID: 8002523 08/01/1994       27 Citations
  • Substance P inhibits ventilation in the goat. (Bisgard GE, Pizarro J, Ryan M, Hedrick M) Adv Exp Med Biol 1994;360:277-9 PMID: 7532902 01/01/1994       1 Citations
  • Carotid body noradrenergic sensitivity in ventilatory acclimatization to hypoxia. (Ryan ML, Hedrick MS, Pizarro J, Bisgard GE) Respir Physiol 1993 Apr;92(1):77-90 PMID: 8390087 04/01/1993       22 Citations
  • Intracarotid norepinephrine infusions inhibit ventilation in goats. (Pizarro J, Warner MM, Ryan M, Mitchell GS, Bisgard GE) Respir Physiol 1992 Dec;90(3):299-310 PMID: 1480841 12/01/1992       19 Citations
  • Last update: 12/01/2018
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