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Nita H. Salzman MD, PhD

Director, Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Gastroenterology

Director of the Center for Microbiome Research
Member of the Cancer Center
Member of the Cardiovascular Center
Member of the Center for Immunology

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Publications (97)

Dermal injury drives a skin to gut axis that disrupts the intestinal microbiome and intestinal immune homeostasis in mice. (Dokoshi T, Chen Y, Cavagnero KJ, Rahman G, Hakim D, Brinton S, Schwarz H, Brown EA, O'Neill A, Nakamura Y, Li F, Salzman NH, Knight R, Gallo RL) Nat Commun 2024 Apr 08;15(1):3009 PMID: 38589392 PMCID: PMC11001995 SCOPUS ID: 2-s2.0-85189779985 04/09/2024

A serum-induced gene signature in hepatocytes is associated with pediatric nonalcoholic fatty liver disease. (Hang Nghiem-Rao T, Johnson JS, Pan A, Atkinson SN, Behling C, Simpson PM, Holtz ML, Weinstock GM, Schwimmer JB, Salzman NH) J Pediatr Gastroenterol Nutr 2024 Apr;78(4):886-897 PMID: 38390691 SCOPUS ID: 2-s2.0-85189912724 02/23/2024

Interleukin-9 production by type 2 innate lymphoid cells induces Paneth cell metaplasia and small intestinal remodeling. (Yuan C, Rayasam A, Moe A, Hayward M, Wells C, Szabo A, Mackenzie A, Salzman N, Drobyski WR) Nat Commun 2023 Dec 02;14(1):7963 PMID: 38042840 PMCID: PMC10693577 SCOPUS ID: 2-s2.0-85178369915 12/03/2023 1 Citation

The intestinal microbiome of children with initial and recurrent nephrolithiasis: A pilot study and exploratory analysis. (Ellison JS, Atkinson SN, Hayward M, Hokanson E, Sheridan KR, Salzman N) J Pediatr Urol 2024 Feb;20(1):18-25 PMID: 37802717 PMCID: PMC10922064 SCOPUS ID: 2-s2.0-85173174514 10/07/2023 1 Citation

BATF is Required for Treg Homeostasis and Stability to Prevent Autoimmune Pathology. (Khatun A, Wu X, Qi F, Gai K, Kharel A, Kudek MR, Fraser L, Ceicko A, Kasmani MY, Majnik A, Burns R, Chen YG, Salzman N, Taparowsky EJ, Fang D, Williams CB, Cui W) Adv Sci (Weinh) 2023 Oct;10(28):e2206692 PMID: 37587835 PMCID: PMC10558681 SCOPUS ID: 2-s2.0-85168114370 08/17/2023 2 Citations

Impact of auricular percutaneous electrical nerve field stimulation on gut microbiome in adolescents with irritable bowel syndrome: A pilot study. (Bora G, Atkinson SN, Pan A, Sood M, Salzman N, Karrento K) J Dig Dis 2023 May;24(5):348-358 PMID: 37448237 SCOPUS ID: 2-s2.0-85167367088 07/14/2023 3 Citations

Tuft cells mediate commensal remodeling of the small intestinal antimicrobial landscape. (Fung C, Fraser LM, Barrón GM, Gologorsky MB, Atkinson SN, Gerrick ER, Hayward M, Ziegelbauer J, Li JA, Nico KF, Tyner MDW, DeSchepper LB, Pan A, Salzman NH, Howitt MR) Proc Natl Acad Sci U S A 2023 Jun 06;120(23):e2216908120 PMID: 37253002 PMCID: PMC10266004 SCOPUS ID: 2-s2.0-85160593821 05/30/2023 6 Citations

Gut microbiota and metabolites drive chronic sickle cell disease pain. (Sadler KE, Atkinson SN, Ehlers VL, Waltz TB, Hayward M, Rodríguez García DM, Salzman NH, Stucky CL, Brandow AM) bioRxiv 2023 Apr 28 PMID: 37163080 PMCID: PMC10168372 05/10/2023

Body Mass Index and Gut Microbiome: A Cluster-Randomized, Controlled, Pilot Feasibility Study. (Frenn M, Salzman N, Lam V, Holtz M, Moosreiner A, Garnier-Villarreal M) Child Obes 2023 Feb 02 PMID: 36730730 SCOPUS ID: 2-s2.0-85163663740 02/03/2023 2 Citations

Lactiplantibacillus plantarum 299v supplementation modulates β-cell ER stress and antioxidative defense pathways and prevents type 1 diabetes in gluten-free BioBreeding rats. (Sargin P, Roethle MF, Jia S, Pant T, Ciecko AE, Atkinson SN, Salzman NH, Teng RJ, Chen YG, Cabrera SM, Hessner MJ) Gut Microbes 2022;14(1):2136467 PMID: 36261888 PMCID: PMC9586621 SCOPUS ID: 2-s2.0-85140364986 10/21/2022 3 Citations

Group 3 innate lymphoid cells require BATF to regulate gut homeostasis in mice. (Wu X, Khatun A, Kasmani MY, Chen Y, Zheng S, Atkinson S, Nguyen C, Burns R, Taparowsky EJ, Salzman NH, Hand TW, Cui W) J Exp Med 2022 Nov 07;219(11) PMID: 36048018 PMCID: PMC9440727 SCOPUS ID: 2-s2.0-85137136864 09/02/2022 11 Citations

A phase 2 trial of a topical antiseptic bundle in head and neck cancer surgery: Effects on surgical site infection and the oral microbiome. (Zenga J, Atkinson S, Yen T, Massey B, Stadler M, Bruening J, Peppard W, Reuben M, Hayward M, Mesich B, Buchan B, Ledeboer N, Sanchez JL, Fraser R, Lin CW, Holtz ML, Awan M, Wong SJ, Puram SV, Salzman N) EBioMedicine 2022 Jul;81:104099 PMID: 35671624 PMCID: PMC9168040 SCOPUS ID: 2-s2.0-85131428877 06/08/2022 3 Citations

Probiotic normalization of systemic inflammation in siblings of type 1 diabetes patients: an open-label pilot study. (Cabrera SM, Coren AT, Pant T, Ciecko AE, Jia S, Roethle MF, Simpson PM, Atkinson SN, Salzman NH, Chen YG, Hessner MJ) Sci Rep 2022 Feb 28;12(1):3306 PMID: 35228584 PMCID: PMC8885673 SCOPUS ID: 2-s2.0-85125563972 03/02/2022 14 Citations

Skin inflammation activates intestinal stromal fibroblasts and promotes colitis. (Dokoshi T, Seidman JS, Cavagnero KJ, Li F, Liggins MC, Taylor BC, Olvera J, Knight R, Chang JT, Salzman NH, Gallo RL) J Clin Invest 2021 Nov 01;131(21) PMID: 34720087 PMCID: PMC8553570 SCOPUS ID: 2-s2.0-85118499787 11/02/2021 14 Citations

Pediatric nonalcoholic fatty liver disease and the microbiome: Mechanisms contributing to pathogenesis and progression. (Salzman NH, Schwimmer JB) Curr Opin Endocr Metab Res 2021 Aug;19:22-29 PMID: 34222711 PMCID: PMC8248528 SCOPUS ID: 2-s2.0-85107994671 07/06/2021 2 Citations

Lactobacillus plantarum 299v probiotic supplementation in men with stable coronary artery disease suppresses systemic inflammation. (Hofeld BC, Puppala VK, Tyagi S, Ahn KW, Anger A, Jia S, Salzman NH, Hessner MJ, Widlansky ME) Sci Rep 2021 Feb 17;11(1):3972 PMID: 33597583 PMCID: PMC7889883 SCOPUS ID: 2-s2.0-85101105180 02/19/2021 11 Citations

Microbial functional change is linked with clinical outcomes after capsular fecal transplant in cirrhosis. (Bajaj JS, Salzman N, Acharya C, Takei H, Kakiyama G, Fagan A, White MB, Gavis EA, Holtz ML, Hayward M, Nittono H, Hylemon PB, Cox IJ, Williams R, Taylor-Robinson SD, Sterling RK, Matherly SC, Fuchs M, Lee H, Puri P, Stravitz RT, Sanyal AJ, Ajayi L, Le Guennec A, Atkinson RA, Siddiqui MS, Luketic V, Pandak WM, Sikaroodi M, Gillevet PM) JCI Insight 2019 Dec 19;4(24) PMID: 31751317 PMCID: PMC6975263 SCOPUS ID: 2-s2.0-85077874836 11/22/2019 47 Citations

Microbiome Signatures Associated With Steatohepatitis and Moderate to Severe Fibrosis in Children With Nonalcoholic Fatty Liver Disease. (Schwimmer JB, Johnson JS, Angeles JE, Behling C, Belt PH, Borecki I, Bross C, Durelle J, Goyal NP, Hamilton G, Holtz ML, Lavine JE, Mitreva M, Newton KP, Pan A, Simpson PM, Sirlin CB, Sodergren E, Tyagi R, Yates KP, Weinstock GM, Salzman NH) Gastroenterology 2019 Oct;157(4):1109-1122 PMID: 31255652 PMCID: PMC6756995 SCOPUS ID: 2-s2.0-85072272749 07/01/2019 180 Citations

Challenges in IBD Research: Preclinical Human IBD Mechanisms. (Pizarro TT, Stappenbeck TS, Rieder F, Rosen MJ, Colombel JF, Donowitz M, Towne J, Mazmanian SK, Faith JJ, Hodin RA, Garrett WS, Fichera A, Poritz LS, Cortes CJ, Shtraizent N, Honig G, Snapper SB, Hurtado-Lorenzo A, Salzman NH, Chang EB) Inflamm Bowel Dis 2019 May 16;25(Suppl 2):S5-S12 PMID: 31095706 SCOPUS ID: 2-s2.0-85066863698 05/17/2019 35 Citations

Fecal Microbial Transplant Capsules Are Safe in Hepatic Encephalopathy: A Phase 1, Randomized, Placebo-Controlled Trial. (Bajaj JS, Salzman NH, Acharya C, Sterling RK, White MB, Gavis EA, Fagan A, Hayward M, Holtz ML, Matherly S, Lee H, Osman M, Siddiqui MS, Fuchs M, Puri P, Sikaroodi M, Gillevet PM) Hepatology 2019 Nov;70(5):1690-1703 PMID: 31038755 PMCID: PMC6819208 SCOPUS ID: 2-s2.0-85067505516 05/01/2019 193 Citations

Longitudinal changes in the gut microbiome of infants on total parenteral nutrition. (Dahlgren AF, Pan A, Lam V, Gouthro KC, Simpson PM, Salzman NH, Nghiem-Rao TH) Pediatr Res 2019 Jul;86(1):107-114 PMID: 30965357 PMCID: PMC6594895 SCOPUS ID: 2-s2.0-85064441222 04/10/2019 40 Citations

Sortase-Dependent Proteins Promote Gastrointestinal Colonization by Enterococci. (Banla LI, Pickrum AM, Hayward M, Kristich CJ, Salzman NH) Infect Immun 2019 Mar;87(5) PMID: 30804098 PMCID: PMC6479037 SCOPUS ID: 2-s2.0-85065021405 02/26/2019 11 Citations

Colonization of the mammalian intestinal tract by enterococci. (Banla LI, Salzman NH, Kristich CJ) Curr Opin Microbiol 2019 Feb;47:26-31 PMID: 30439685 PMCID: PMC6511500 SCOPUS ID: 2-s2.0-85056238106 11/16/2018 21 Citations

Engineered E. coli Nissle 1917 for the reduction of vancomycin-resistant Enterococcus in the intestinal tract. (Geldart KG, Kommineni S, Forbes M, Hayward M, Dunny GM, Salzman NH, Kaznessis YN) Bioeng Transl Med 2018 Sep;3(3):197-208 PMID: 30377660 PMCID: PMC6195901 11/01/2018

Lactobacillus plantarum 299v Supplementation Improves Vascular Endothelial Function and Reduces Inflammatory Biomarkers in Men With Stable Coronary Artery Disease. (Malik M, Suboc TM, Tyagi S, Salzman N, Wang J, Ying R, Tanner MJ, Kakarla M, Baker JE, Widlansky ME) Circ Res 2018 Oct 12;123(9):1091-1102 PMID: 30355158 PMCID: PMC6205737 SCOPUS ID: 2-s2.0-85055600525 10/26/2018 128 Citations

Ceftriaxone Administration Disrupts Intestinal Homeostasis, Mediating Noninflammatory Proliferation and Dissemination of Commensal Enterococci. (Chakraborty R, Lam V, Kommineni S, Stromich J, Hayward M, Kristich CJ, Salzman NH) Infect Immun 2018 Dec;86(12) PMID: 30224553 PMCID: PMC6246901 SCOPUS ID: 2-s2.0-85056802367 09/19/2018 28 Citations

Intestinal Microbiota Disruption Reduces Regulatory T Cells and Increases Respiratory Viral Infection Mortality Through Increased IFNγ Production. (Grayson MH, Camarda LE, Hussain SA, Zemple SJ, Hayward M, Lam V, Hunter DA, Santoro JL, Rohlfing M, Cheung DS, Salzman NH) Front Immunol 2018;9:1587 PMID: 30042764 PMCID: PMC6048222 SCOPUS ID: 2-s2.0-85049830838 07/26/2018 49 Citations

Exploring bioactive peptides from bacterial secretomes using PepSAVI-MS: identification and characterization of Bac-21 from Enterococcus faecalis pPD1. (Kirkpatrick CL, Parsley NC, Bartges TE, Wing CE, Kommineni S, Kristich CJ, Salzman NH, Patrie SM, Hicks LM) Microb Biotechnol 2018 Sep;11(5):943-951 PMID: 30014612 PMCID: PMC6116741 SCOPUS ID: 2-s2.0-85050586641 07/18/2018 6 Citations

A model of TH17-associated ileal hyperplasia that requires both IL-17A and IFNγ to generate self-tolerance and prevent colitis. (Jeschke JC, Mayne CG, Ziegelbauer J, DeCiantis CL, Singh S, Kumar SN, Suchi M, Iwakura Y, Drobyski WR, Salzman NH, Williams CB) Mucosal Immunol 2018 Jul;11(4):1127-1137 PMID: 29728642 PMCID: PMC6571016 SCOPUS ID: 2-s2.0-85046438531 05/08/2018 3 Citations

A screen of Crohn's disease-associated microbial metabolites identifies ascorbate as a novel metabolic inhibitor of activated human T cells. (Chang YL, Rossetti M, Vlamakis H, Casero D, Sunga G, Harre N, Miller S, Humphries R, Stappenbeck T, Simpson KW, Sartor RB, Wu G, Lewis J, Bushman F, McGovern DPB, Salzman N, Borneman J, Xavier R, Huttenhower C, Braun J) Mucosal Immunol 2019 Mar;12(2):457-467 PMID: 29695840 PMCID: PMC6202286 SCOPUS ID: 2-s2.0-85046035681 04/27/2018 40 Citations

Modulation of the diet and gastrointestinal microbiota normalizes systemic inflammation and β-cell chemokine expression associated with autoimmune diabetes susceptibility. (Henschel AM, Cabrera SM, Kaldunski ML, Jia S, Geoffrey R, Roethle MF, Lam V, Chen YG, Wang X, Salzman NH, Hessner MJ) PLoS One 2018;13(1):e0190351 PMID: 29293587 PMCID: PMC5749787 SCOPUS ID: 2-s2.0-85039965631 01/03/2018 20 Citations

Modulators of Enterococcus faecalis Cell Envelope Integrity and Antimicrobial Resistance Influence Stable Colonization of the Mammalian Gastrointestinal Tract. (Banla IL, Kommineni S, Hayward M, Rodrigues M, Palmer KL, Salzman NH, Kristich CJ) Infect Immun 2018 Jan;86(1) PMID: 29038125 PMCID: PMC5736811 SCOPUS ID: 2-s2.0-85039561569 10/19/2017 21 Citations

Intestinal alkaline phosphatase deficiency leads to dysbiosis and bacterial translocation in the newborn intestine. (Fawley J, Koehler S, Cabrera S, Lam V, Fredrich K, Hessner M, Salzman N, Gourlay D) J Surg Res 2017 Oct;218:35-42 PMID: 28985873 SCOPUS ID: 2-s2.0-85020395721 10/08/2017 21 Citations

Continued Alcohol Misuse in Human Cirrhosis is Associated with an Impaired Gut-Liver Axis. (Bajaj JS, Kakiyama G, Zhao D, Takei H, Fagan A, Hylemon P, Zhou H, Pandak WM, Nittono H, Fiehn O, Salzman N, Holtz M, Simpson P, Gavis EA, Heuman DM, Liu R, Kang DJ, Sikaroodi M, Gillevet PM) Alcohol Clin Exp Res 2017 Nov;41(11):1857-1865 PMID: 28925102 SCOPUS ID: 2-s2.0-85031109936 09/20/2017 90 Citations

Black Raspberries and Their Anthocyanin and Fiber Fractions Alter the Composition and Diversity of Gut Microbiota in F-344 Rats. (Pan P, Lam V, Salzman N, Huang YW, Yu J, Zhang J, Wang LS) Nutr Cancer 2017;69(6):943-951 PMID: 28718724 PMCID: PMC6139254 SCOPUS ID: 2-s2.0-85024493672 07/19/2017 78 Citations

Harnessing bacteriocin biology as targeted therapy in the GI tract. (Kommineni S, Kristich CJ, Salzman NH) Gut Microbes 2016 Nov;7(6):512-517 PMID: 27624536 PMCID: PMC5153615 SCOPUS ID: 2-s2.0-84989252479 11/03/2016 15 Citations

Paneth cell defects in Crohn's disease patients promote dysbiosis. (Liu TC, Gurram B, Baldridge MT, Head R, Lam V, Luo C, Cao Y, Simpson P, Hayward M, Holtz ML, Bousounis P, Noe J, Lerner D, Cabrera J, Biank V, Stephens M, Huttenhower C, McGovern DP, Xavier RJ, Stappenbeck TS, Salzman NH) JCI Insight 2016 Jun 02;1(8):e86907 PMID: 27699268 PMCID: PMC5033844 SCOPUS ID: 2-s2.0-85055598517 10/05/2016 83 Citations

Intestinal Microbial Metabolites Are Linked to Severity of Myocardial Infarction in Rats. (Lam V, Su J, Hsu A, Gross GJ, Salzman NH, Baker JE) PLoS One 2016;11(8):e0160840 PMID: 27505423 PMCID: PMC4978455 SCOPUS ID: 2-s2.0-84983638440 08/10/2016 108 Citations

Alternatively Activated Macrophages Boost Induced Regulatory T and Th17 Cell Responses during Immunotherapy for Colitis. (Haribhai D, Ziegelbauer J, Jia S, Upchurch K, Yan K, Schmitt EG, Salzman NH, Simpson P, Hessner MJ, Chatila TA, Williams CB) J Immunol 2016 Apr 15;196(8):3305-17 PMID: 26927797 PMCID: PMC4851766 SCOPUS ID: 2-s2.0-84974839190 03/02/2016 37 Citations

O-011 Paneth Cell Phenotypes Define a Subtype of Pediatric Crohn's Disease Through Alterations in Host-Microbial Interactions (Ta-Chiang Liu, Bhaskar Gurram, Megan Baldridge, Richard Head, Vy Lam, Chengwei Luo, Yumei Cao, Pippa Simpson, Michael Hayward, Mary Holtz, Joshua Noe, Diana Lerner, Jose Cabrera, Vincent Biank, Michael Stephens, Curtis Huttenhower, Dermot McGovern, Ramnik Xavier, Thaddeus Stappenbeck, Nita Salzman) Inflammatory Bowel Diseases Inflammatory Bowel Diseases, Volume 22, Issue suppl_1, March 2016, Page S4, 03/01/2016

Intact Regulatory T-Cell Function but Defective Generation of IL-17A-Producing CD4+ T Cells in XIAP Deficiency. (Gurram B, Hammelev E, Syverson G, Haribhai D, Yan K, Simpson P, Salzman N, Verbsky JW) J Pediatr Gastroenterol Nutr 2016 Aug;63(2):218-25 PMID: 26825770 SCOPUS ID: 2-s2.0-84955587050 01/31/2016

Plasma-induced signatures reveal an extracellular milieu possessing an immunoregulatory bias in treatment-naive paediatric inflammatory bowel disease. (Gurram B, Salzman NH, Kaldunski ML, Jia S, Li BU, Stephens M, Sood MR, Hessner MJ) Clin Exp Immunol 2016 Apr;184(1):36-49 PMID: 26660358 PMCID: PMC4778097 SCOPUS ID: 2-s2.0-84960311190 12/15/2015 10 Citations

Bacteriocin production augments niche competition by enterococci in the mammalian gastrointestinal tract. (Kommineni S, Bretl DJ, Lam V, Chakraborty R, Hayward M, Simpson P, Cao Y, Bousounis P, Kristich CJ, Salzman NH) Nature 2015 Oct 29;526(7575):719-22 PMID: 26479034 PMCID: PMC4978352 SCOPUS ID: 2-s2.0-84945964162 10/20/2015 295 Citations

Gut Microbial Dysbiosis Due to Helicobacter Drives an Increase in Marginal Zone B Cells in the Absence of IL-10 Signaling in Macrophages. (Ray A, Basu S, Gharaibeh RZ, Cook LC, Kumar R, Lefkowitz EJ, Walker CR, Morrow CD, Franklin CL, Geiger TL, Salzman NH, Fodor A, Dittel BN) J Immunol 2015 Oct 01;195(7):3071-85 PMID: 26324769 PMCID: PMC4575870 SCOPUS ID: 2-s2.0-84942475191 09/02/2015 21 Citations

Increased susceptibility to otitis media in a Splunc1-deficient mouse model. (Bartlett JA, Meyerholz DK, Wohlford-Lenane CL, Naumann PW, Salzman NH, McCray PB Jr) Dis Model Mech 2015 May;8(5):501-8 PMID: 25765466 PMCID: PMC4415896 SCOPUS ID: 2-s2.0-84928992266 03/15/2015 16 Citations

Selection of models for the analysis of risk-factor trees: leveraging biological knowledge to mine large sets of risk factors with application to microbiome data. (Zhang Q, Abel H, Wells A, Lenzini P, Gomez F, Province MA, Templeton AA, Weinstock GM, Salzman NH, Borecki IB) Bioinformatics 2015 May 15;31(10):1607-13 PMID: 25568281 PMCID: PMC4426830 SCOPUS ID: 2-s2.0-84929616310 01/09/2015 10 Citations

The role of the microbiome in immune cell development. (Salzman NH) Ann Allergy Asthma Immunol 2014 Dec;113(6):593-8 PMID: 25466801 SCOPUS ID: 2-s2.0-84919657877 12/04/2014 19 Citations

Detection of antimicrobial (poly)peptides with acid urea polyacrylamide gel electrophoresis followed by Western immunoblot. (Porter E, Valore EV, Anouseyan R, Salzman NH) Methods Mol Biol 2015;1225:105-15 PMID: 25253251 SCOPUS ID: 2-s2.0-84954585313 09/26/2014 3 Citations

Calprotectin in cystic fibrosis. (Rumman N, Sultan M, El-Chammas K, Goh V, Salzman N, Quintero D, Werlin S) BMC Pediatr 2014 May 29;14:133 PMID: 24885444 PMCID: PMC4048584 SCOPUS ID: 2-s2.0-84902083473 06/03/2014 37 Citations

Conventional CD4+ T cells regulate IL-22-producing intestinal innate lymphoid cells. (Korn LL, Thomas HL, Hubbeling HG, Spencer SP, Sinha R, Simkins HM, Salzman NH, Bushman FD, Laufer TM) Mucosal Immunol 2014 Sep;7(5):1045-57 PMID: 24448096 PMCID: PMC4107180 SCOPUS ID: 2-s2.0-84900485129 01/23/2014 65 Citations

Dysbiosis--a consequence of Paneth cell dysfunction. (Salzman NH, Bevins CL) Semin Immunol 2013 Nov 30;25(5):334-41 PMID: 24239045 SCOPUS ID: 2-s2.0-84888858078 11/19/2013 77 Citations

Chronic follicular bronchiolitis requires antigen-specific regulatory T cell control to prevent fatal disease progression. (Schmitt EG, Haribhai D, Jeschke JC, Co DO, Ziegelbauer J, Yan K, Iwakura Y, Mishra MK, Simpson P, Salzman NH, Williams CB) J Immunol 2013 Dec 01;191(11):5460-76 PMID: 24163409 PMCID: PMC3893829 SCOPUS ID: 2-s2.0-84888363726 10/29/2013 4 Citations

Loss of TLR2 worsens spontaneous colitis in MDR1A deficiency through commensally induced pyroptosis. (Ey B, Eyking A, Klepak M, Salzman NH, Göthert JR, Rünzi M, Schmid KW, Gerken G, Podolsky DK, Cario E) J Immunol 2013 Jun 01;190(11):5676-88 PMID: 23636052 PMCID: PMC3659955 SCOPUS ID: 2-s2.0-84878085749 05/03/2013 49 Citations

Anthocyanins, anthocyanin derivatives, and colorectal cancer (Wang LS, Kuo CT, Peiffer D, Seguin C, Stoner K, Huang YW, Huang THM, Salzman N, Liu Z, Rosenberg D, Yang GY, Yang W, Bi X, Carmella S, Hecht S, Stoner G) Anthocyanins in Health and Disease 1 January 2013:225-243 SCOPUS ID: 2-s2.0-85054214291 01/01/2013 2 Citations

IL-10 produced by induced regulatory T cells (iTregs) controls colitis and pathogenic ex-iTregs during immunotherapy. (Schmitt EG, Haribhai D, Williams JB, Aggarwal P, Jia S, Charbonnier LM, Yan K, Lorier R, Turner A, Ziegelbauer J, Georgiev P, Simpson P, Salzman NH, Hessner MJ, Broeckel U, Chatila TA, Williams CB) J Immunol 2012 Dec 15;189(12):5638-48 PMID: 23125413 PMCID: PMC3537488 SCOPUS ID: 2-s2.0-84871173673 11/06/2012 71 Citations

Response. (Lam V, Su J, Koprowski S, Hsu A, Tweddell JS, Rafiee P, Gross GJ, Salzman NH, Baker JE) FASEB J 2012 Nov;26(11):4388-4389 PMID: 29426239 11/01/2012

Response (Lam V, Su J, Koprowski S, Hsu A, Tweddell JS, Rafiee P, Gross GJ, Salzman NH, Baker JE) FASEB Journal November 2012;26(11):4388-4389 SCOPUS ID: 2-s2.0-84868288417 11/01/2012 2 Citations

The β₃-integrin ligand of Borrelia burgdorferi is critical for infection of mice but not ticks. (Ristow LC, Miller HE, Padmore LJ, Chettri R, Salzman N, Caimano MJ, Rosa PA, Coburn J) Mol Microbiol 2012 Sep;85(6):1105-18 PMID: 22758390 PMCID: PMC3438374 SCOPUS ID: 2-s2.0-84866024708 07/05/2012 48 Citations

Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets. (Chu H, Pazgier M, Jung G, Nuccio SP, Castillo PA, de Jong MF, Winter MG, Winter SE, Wehkamp J, Shen B, Salzman NH, Underwood MA, Tsolis RM, Young GM, Lu W, Lehrer RI, Bäumler AJ, Bevins CL) Science 2012 Jul 27;337(6093):477-81 PMID: 22722251 PMCID: PMC4332406 SCOPUS ID: 2-s2.0-84864335926 06/23/2012 309 Citations

MprA and DosR coregulate a Mycobacterium tuberculosis virulence operon encoding Rv1813c and Rv1812c. (Bretl DJ, He H, Demetriadou C, White MJ, Penoske RM, Salzman NH, Zahrt TC) Infect Immun 2012 Sep;80(9):3018-33 PMID: 22689819 PMCID: PMC3418728 SCOPUS ID: 2-s2.0-84867585909 06/13/2012 37 Citations

Intestinal microbiota as novel biomarkers of prior radiation exposure. (Lam V, Moulder JE, Salzman NH, Dubinsky EA, Andersen GL, Baker JE) Radiat Res 2012 May;177(5):573-83 PMID: 22439602 SCOPUS ID: 2-s2.0-84861374205 03/24/2012 63 Citations

A novel IL-10-independent regulatory role for B cells in suppressing autoimmunity by maintenance of regulatory T cells via GITR ligand. (Ray A, Basu S, Williams CB, Salzman NH, Dittel BN) J Immunol 2012 Apr 01;188(7):3188-98 PMID: 22368274 PMCID: PMC3311743 SCOPUS ID: 2-s2.0-84859376769 03/01/2012 221 Citations

Alternative luminal activation mechanisms for paneth cell α-defensins. (Mastroianni JR, Costales JK, Zaksheske J, Selsted ME, Salzman NH, Ouellette AJ) J Biol Chem 2012 Mar 30;287(14):11205-12 PMID: 22334698 PMCID: PMC3322892 SCOPUS ID: 2-s2.0-84859503402 02/16/2012 35 Citations

Intestinal microbiota determine severity of myocardial infarction in rats. (Lam V, Su J, Koprowski S, Hsu A, Tweddell JS, Rafiee P, Gross GJ, Salzman NH, Baker JE) FASEB J 2012 Apr;26(4):1727-35 PMID: 22247331 PMCID: PMC3316900 SCOPUS ID: 2-s2.0-84860909327 01/17/2012 245 Citations

Expansion of Paneth cell population in response to enteric Salmonella enterica serovar Typhimurium infection. (Martinez Rodriguez NR, Eloi MD, Huynh A, Dominguez T, Lam AH, Carcamo-Molina D, Naser Z, Desharnais R, Salzman NH, Porter E) Infect Immun 2012 Jan;80(1):266-75 PMID: 22006567 PMCID: PMC3255647 SCOPUS ID: 2-s2.0-84857065857 10/19/2011 54 Citations

The potter's wheel: the host's role in sculpting its microbiota. (Bevins CL, Salzman NH) Cell Mol Life Sci 2011 Nov;68(22):3675-85 PMID: 21968920 PMCID: PMC3222938 SCOPUS ID: 2-s2.0-82155195889 10/05/2011 97 Citations

A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. (Haribhai D, Williams JB, Jia S, Nickerson D, Schmitt EG, Edwards B, Ziegelbauer J, Yassai M, Li SH, Relland LM, Wise PM, Chen A, Zheng YQ, Simpson PM, Gorski J, Salzman NH, Hessner MJ, Chatila TA, Williams CB) Immunity 2011 Jul 22;35(1):109-22 PMID: 21723159 PMCID: PMC3295638 SCOPUS ID: 2-s2.0-79960453738 07/05/2011 352 Citations

Targeted intestinal epithelial deletion of the chemokine receptor CXCR4 reveals important roles for extracellular-regulated kinase-1/2 in restitution. (Zimmerman NP, Vongsa RA, Faherty SL, Salzman NH, Dwinell MB) Lab Invest 2011 Jul;91(7):1040-55 PMID: 21537329 PMCID: PMC3167207 SCOPUS ID: 2-s2.0-79959760786 05/04/2011 26 Citations

Paneth cell defensins and the regulation of the microbiome: détente at mucosal surfaces. (Salzman NH) Gut Microbes 2010;1(6):401-6 PMID: 21468224 PMCID: PMC3056107 SCOPUS ID: 2-s2.0-79251585301 04/07/2011 97 Citations

Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. (Bevins CL, Salzman NH) Nat Rev Microbiol 2011 May;9(5):356-68 PMID: 21423246 SCOPUS ID: 2-s2.0-79954915318 03/23/2011 872 Citations

How bugs and men live in harmony. Role of defensins in gut microbial composition and Th17 development. (Bos NA, Salzman N) Immunol Lett 2011 Jul;138(1):25-7 PMID: 21333685 SCOPUS ID: 2-s2.0-79957777966 02/22/2011 4 Citations

Control of intestinal Nod2-mediated peptidoglycan recognition by epithelium-associated lymphocytes. (Duerr CU, Salzman NH, Dupont A, Szabo A, Normark BH, Normark S, Locksley RM, Mellroth P, Hornef MW) Mucosal Immunol 2011 May;4(3):325-34 PMID: 20980996 SCOPUS ID: 2-s2.0-79955079700 10/29/2010 24 Citations

Microbiota-immune system interaction: an uneasy alliance. (Salzman NH) Curr Opin Microbiol 2011 Feb;14(1):99-105 PMID: 20971034 PMCID: PMC3029469 SCOPUS ID: 2-s2.0-79551686484 10/26/2010 78 Citations

Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum. (Biswas A, Liu YJ, Hao L, Mizoguchi A, Salzman NH, Bevins CL, Kobayashi KS) Proc Natl Acad Sci U S A 2010 Aug 17;107(33):14739-44 PMID: 20679225 PMCID: PMC2930434 SCOPUS ID: 2-s2.0-77957047689 08/04/2010 139 Citations

Enteric defensins are essential regulators of intestinal microbial ecology. (Salzman NH, Hung K, Haribhai D, Chu H, Karlsson-Sjöberg J, Amir E, Teggatz P, Barman M, Hayward M, Eastwood D, Stoel M, Zhou Y, Sodergren E, Weinstock GM, Bevins CL, Williams CB, Bos NA) Nat Immunol 2010 Jan;11(1):76-83 PMID: 19855381 PMCID: PMC2795796 SCOPUS ID: 2-s2.0-74049122536 10/27/2009 933 Citations

Prolonged impact of antibiotics on intestinal microbial ecology and susceptibility to enteric Salmonella infection. (Croswell A, Amir E, Teggatz P, Barman M, Salzman NH) Infect Immun 2009 Jul;77(7):2741-53 PMID: 19380465 PMCID: PMC2708550 SCOPUS ID: 2-s2.0-67650076454 04/22/2009 220 Citations

A central role for induced regulatory T cells in tolerance induction in experimental colitis. (Haribhai D, Lin W, Edwards B, Ziegelbauer J, Salzman NH, Carlson MR, Li SH, Simpson PM, Chatila TA, Williams CB) J Immunol 2009 Mar 15;182(6):3461-8 PMID: 19265124 PMCID: PMC2763205 SCOPUS ID: 2-s2.0-65449136307 03/07/2009 191 Citations

A randomized placebo-controlled comparison of 2 prebiotic/probiotic combinations in preterm infants: impact on weight gain, intestinal microbiota, and fecal short-chain fatty acids. (Underwood MA, Salzman NH, Bennett SH, Barman M, Mills DA, Marcobal A, Tancredi DJ, Bevins CL, Sherman MP) J Pediatr Gastroenterol Nutr 2009 Feb;48(2):216-25 PMID: 19179885 PMCID: PMC2743418 SCOPUS ID: 2-s2.0-66149153878 01/31/2009 139 Citations

Negative interactions with the microbiota: IBD. (Salzman NH, Bevins CL) Adv Exp Med Biol 2008;635:67-78 PMID: 18841704 SCOPUS ID: 2-s2.0-58149142746 10/10/2008 28 Citations

A Francisella tularensis Schu S4 purine auxotroph is highly attenuated in mice but offers limited protection against homologous intranasal challenge. (Pechous RD, McCarthy TR, Mohapatra NP, Soni S, Penoske RM, Salzman NH, Frank DW, Gunn JS, Zahrt TC) PLoS One 2008 Jun 25;3(6):e2487 PMID: 18575611 PMCID: PMC2429968 SCOPUS ID: 2-s2.0-49649100202 06/26/2008 64 Citations

Defensins versus bacteria: not just antibiotics anymore. (Salzman NH) Gastroenterology 2008 Jun;134(7):2174-7 PMID: 18486618 SCOPUS ID: 2-s2.0-44649158420 05/20/2008 6 Citations

Enteric salmonellosis disrupts the microbial ecology of the murine gastrointestinal tract. (Barman M, Unold D, Shifley K, Amir E, Hung K, Bos N, Salzman N) Infect Immun 2008 Mar;76(3):907-15 PMID: 18160481 PMCID: PMC2258829 SCOPUS ID: 2-s2.0-40749084834 12/28/2007 334 Citations

Prolonged colonization of mice by Vibrio cholerae El Tor O1 depends on accessory toxins. (Olivier V, Salzman NH, Satchell KJ) Infect Immun 2007 Oct;75(10):5043-51 PMID: 17698571 PMCID: PMC2044531 SCOPUS ID: 2-s2.0-34848891814 08/19/2007 69 Citations

Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa. (Salzman NH, Underwood MA, Bevins CL) Semin Immunol 2007 Apr;19(2):70-83 PMID: 17485224 SCOPUS ID: 2-s2.0-34249313567 05/09/2007 329 Citations

Reduced Paneth cell alpha-defensins in ileal Crohn's disease. (Wehkamp J, Salzman NH, Porter E, Nuding S, Weichenthal M, Petras RE, Shen B, Schaeffeler E, Schwab M, Linzmeier R, Feathers RW, Chu H, Lima H Jr, Fellermann K, Ganz T, Stange EF, Bevins CL) Proc Natl Acad Sci U S A 2005 Dec 13;102(50):18129-34 PMID: 16330776 PMCID: PMC1306791 SCOPUS ID: 2-s2.0-29144483937 12/07/2005 830 Citations

Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. (Salzman NH, Ghosh D, Huttner KM, Paterson Y, Bevins CL) Nature 2003 Apr 03;422(6931):522-6 PMID: 12660734 SCOPUS ID: 2-s2.0-0037417311 03/28/2003 658 Citations

Enteric salmonella infection inhibits Paneth cell antimicrobial peptide expression. (Salzman NH, Chou MM, de Jong H, Liu L, Porter EM, Paterson Y) Infect Immun 2003 Mar;71(3):1109-15 PMID: 12595421 PMCID: PMC148886 SCOPUS ID: 2-s2.0-0037372643 02/22/2003 122 Citations

Analysis of 16S libraries of mouse gastrointestinal microflora reveals a large new group of mouse intestinal bacteria. (Salzman NH, de Jong H, Paterson Y, Harmsen HJM, Welling GW, Bos NA) Microbiology (Reading) 2002 Nov;148(Pt 11):3651-3660 PMID: 12427955 SCOPUS ID: 2-s2.0-0036854372 11/13/2002 212 Citations

Anatomic and functional characteristics of the rat ileal pouch. (Chen CN, McVay LD, Batlivala ZS, Hendren SK, Swain GP, Salzman N, Williams NN, Rombeau JL) Am J Surg 2002 Apr;183(4):464-70 PMID: 11975937 SCOPUS ID: 2-s2.0-0036224928 04/27/2002 8 Citations

Enteric defensin expression in necrotizing enterocolitis. (Salzman NH, Polin RA, Harris MC, Ruchelli E, Hebra A, Zirin-Butler S, Jawad A, Martin Porter E, Bevins CL) Pediatr Res 1998 Jul;44(1):20-6 PMID: 9667365 SCOPUS ID: 2-s2.0-0031844367 07/17/1998 114 Citations

Human enteric defensins. Gene structure and developmental expression. (Mallow EB, Harris A, Salzman N, Russell JP, DeBerardinis RJ, Ruchelli E, Bevins CL) J Biol Chem 1996 Feb 23;271(8):4038-45 PMID: 8626737 SCOPUS ID: 2-s2.0-0030029451 02/23/1996 270 Citations

Quantitative fluorescence techniques for the characterization of endocytosis in intact cells. (Salzman NH, Maxfield FR) Subcell Biochem 1993;19:95-123 PMID: 8385822 SCOPUS ID: 2-s2.0-0027346761 01/01/1993 7 Citations

Fusion accessibility of endocytic compartments along the recycling and lysosomal endocytic pathways in intact cells. (Salzman NH, Maxfield FR) J Cell Biol 1989 Nov;109(5):2097-104 PMID: 2681226 PMCID: PMC2115866 SCOPUS ID: 2-s2.0-0024454465 11/01/1989 100 Citations

Intracellular fusion of sequentially formed endocytic compartments. (Salzman NH, Maxfield FR) J Cell Biol 1988 Apr;106(4):1083-91 PMID: 3360848 PMCID: PMC2115012 SCOPUS ID: 2-s2.0-0023887115 04/01/1988 59 Citations

NMR Characterization of the Chemical Microstructure of Vinylidene Halide and Vinyl Halide Copolymers (Cais RE, Kometani JM, Salzman NH) Macromolecules 1986;19(4):1006-1012 SCOPUS ID: 2-s2.0-0012422786 01/01/1986 5 Citations

NMR CHARACTERIZATION OF THE CHEMICAL MICROSTRUCTURE OF VINYLIDENE HALIDE AND VINYL HALIDE COPOLYMERS. (Cais RE, Kometani JM, Salzman NH) Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Material 1984;50:285-289 SCOPUS ID: 2-s2.0-0021615668 12/01/1984 1 Citation

Annual chemical congress: Polymer analysis (Gerrard DL, Coleman MM, Gordon B, Lehrle RS, McNeill IC, Cais RE, Kometani JM, Salzman NH) Analytical Proceedings 1983;20(11):569-582 SCOPUS ID: 2-s2.0-37049105632 01/01/1983 3 Citations

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Profiles for MCW, MU, MSOE, UWM, BCW, CW, Froedtert, and VA Faculty

Nita H. Salzman MD, PhD

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Publications (97)