Medical College of Wisconsin
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Pui Ying Lam PhD

Pui Ying Lam PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Cell Biology, Neurobiology and Anatomy
Program: Administration

Member of the Center for Immunology


I am willing to collaborate on research projects.

View Curriculum Vitae

Research Areas of Interest

  • Calcium
  • Disease Models, Animal
  • Inflammation
  • Macrophages
  • Neutrophils
  • Optogenetics
  • Signal Transduction
  • Time-Lapse Imaging
  • Zebrafish
  • neuroinflammation
  • Danionella cerebrum
  • Photopharmacology

    • Research Experience

  • Actins
  • Animals, Genetically Modified
  • Calcium
  • Cell Movement
  • Cell Polarity
  • Chemotaxis
  • Disease Models, Animal
  • Gene Expression Regulation
  • In Situ Hybridization
  • Macrophages
  • Microtubules
  • Neutrophils
  • Optogenetics
  • Signal Transduction
  • TRPA1 Cation Channel
  • Time-Lapse Imaging
  • Zebrafish
  • Danionella cerebrum

    • Methodologies and Techniques

  • Time-Lapse Imaging
  • Zebrafish

    • Educational Expertise

  • Macrophages
  • Neutrophils
  • Time-Lapse Imaging
  • Zebrafish

    • Publications (26)

  • The conducting state of TRPA1 modulates channel lateral mobility (Sampieri A, Padilla-Flores T, Thawani AR, Lam PY, Fuchter MJ, Peterson R, Vaca L) Cell Calcium December 2023;116 SCOPUS ID: 2-s2.0-85172678285 12/01/2023    
  • Longitudinal in vivo imaging of adult Danionella cerebrum using standard confocal microscopy. (Lam PY) Dis Model Mech 2022 Dec 01;15(12) PMID: 36398624 PMCID: PMC9844135 SCOPUS ID: 2-s2.0-85144499718 11/19/2022       4 Citations
  • Cell type specific gene expression profiling reveals a role for complement component C3 in neutrophil responses to tissue damage. (Houseright RA, Rosowski EE, Lam PY, Tauzin SJM, Mulvaney O, Dewey CN, Huttenlocher A) Sci Rep 2020 Sep 24;10(1):15716 PMID: 32973200 PMCID: PMC7518243 SCOPUS ID: 2-s2.0-85091432160 09/26/2020       12 Citations
  • TRPswitch-A Step-Function Chemo-optogenetic Ligand for the Vertebrate TRPA1 Channel. (Lam PY, Thawani AR, Balderas E, White AJP, Chaudhuri D, Fuchter MJ, Peterson RT) J Am Chem Soc 2020 Oct 14;142(41):17457-17468 PMID: 32966062 PMCID: PMC8011302 SCOPUS ID: 2-s2.0-85092945882 09/24/2020       16 Citations
  • Boholamide A, an APD-Class, Hypoxia-Selective Cyclodepsipeptide. (Torres JP, Lin Z, Fenton DS, Leavitt LU, Niu C, Lam PY, Robes JM, Peterson RT, Concepcion GP, Haygood MG, Olivera BM, Schmidt EW) J Nat Prod 2020 Apr 24;83(4):1249-1257 PMID: 32186874 PMCID: PMC10172148 SCOPUS ID: 2-s2.0-85082040097 03/19/2020       9 Citations
  • Cyp1 Inhibition Prevents Doxorubicin-Induced Cardiomyopathy in a Zebrafish Heart-Failure Model. (Lam PY, Kutchukian P, Anand R, Imbriglio J, Andrews C, Padilla H, Vohra A, Lane S, Parker DL Jr, Cornella Taracido I, Johns DG, Beerens M, MacRae CA, Caldwell JP, Sorota S, Asnani A, Peterson RT) Chembiochem 2020 Jul 01;21(13):1905-1910 PMID: 32003101 PMCID: PMC7500981 SCOPUS ID: 2-s2.0-85080951472 02/01/2020       15 Citations
  • Efficient Front-Rear Coupling in Neutrophil Chemotaxis by Dynamic Myosin II Localization. (Tsai TY, Collins SR, Chan CK, Hadjitheodorou A, Lam PY, Lou SS, Yang HW, Jorgensen J, Ellett F, Irimia D, Davidson MW, Fischer RS, Huttenlocher A, Meyer T, Ferrell JE Jr, Theriot JA) Dev Cell 2019 Apr 22;49(2):189-205.e6 PMID: 31014479 PMCID: PMC6708378 SCOPUS ID: 2-s2.0-85064090810 04/25/2019       45 Citations
  • Developing zebrafish disease models for in vivo small molecule screens. (Lam PY, Peterson RT) Curr Opin Chem Biol 2019 Jun;50:37-44 PMID: 30928773 PMCID: PMC6800242 SCOPUS ID: 2-s2.0-85063391592 04/01/2019       57 Citations
  • Filopodia and focal adhesions: An integrated system driving branching morphogenesis in neuronal pathfinding and angiogenesis. (Fischer RS, Lam PY, Huttenlocher A, Waterman CM) Dev Biol 2019 Jul 01;451(1):86-95 PMID: 30193787 PMCID: PMC7082808 SCOPUS ID: 2-s2.0-85053325520 09/09/2018       45 Citations
  • Noncanonical translation via deadenylated 3' UTRs maintains primordial germ cells. (Jin YN, Schlueter PJ, Jurisch-Yaksi N, Lam PY, Jin S, Hwang WY, Yeh JJ, Yoshigi M, Ong SE, Schenone M, Hartigan CR, Carr SA, Peterson RT) Nat Chem Biol 2018 Sep;14(9):844-852 PMID: 29988067 PMCID: PMC6800240 SCOPUS ID: 2-s2.0-85049618175 07/11/2018       7 Citations
  • Live imaging reveals distinct modes of neutrophil and macrophage migration within interstitial tissues. (Barros-Becker F, Lam PY, Fisher R, Huttenlocher A) J Cell Sci 2017 Nov 15;130(22):3801-3808 PMID: 28972134 PMCID: PMC5702045 SCOPUS ID: 2-s2.0-85034080622 10/04/2017       66 Citations
  • A high-conductance chemo-optogenetic system based on the vertebrate channel Trpa1b. (Lam PY, Mendu SK, Mills RW, Zheng B, Padilla H, Milan DJ, Desai BN, Peterson RT) Sci Rep 2017 Sep 19;7(1):11839 PMID: 28928472 PMCID: PMC5605526 SCOPUS ID: 2-s2.0-85029827979 09/21/2017       14 Citations
  • Macrophages mediate flagellin induced inflammasome activation and host defense in zebrafish. (Vincent WJ, Freisinger CM, Lam PY, Huttenlocher A, Sauer JD) Cell Microbiol 2016 Apr;18(4):591-604 PMID: 26468080 PMCID: PMC5027955 SCOPUS ID: 2-s2.0-84961207801 10/16/2015       59 Citations
  • In vivo imaging and characterization of actin microridges. (Lam PY, Mangos S, Green JM, Reiser J, Huttenlocher A) PLoS One 2015;10(1):e0115639 PMID: 25629723 PMCID: PMC4309568 SCOPUS ID: 2-s2.0-84961306974 01/30/2015       38 Citations
  • Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration. (Tauzin S, Starnes TW, Becker FB, Lam PY, Huttenlocher A) J Cell Biol 2014 Dec 08;207(5):589-98 PMID: 25488917 PMCID: PMC4259815 SCOPUS ID: 2-s2.0-84920019093 12/10/2014       102 Citations
  • Spinning disk confocal imaging of neutrophil migration in zebrafish. (Lam PY, Fischer RS, Shin WD, Waterman CM, Huttenlocher A) Methods Mol Biol 2014;1124:219-33 PMID: 24504955 PMCID: PMC4087032 SCOPUS ID: 2-s2.0-84898932691 02/08/2014       19 Citations
  • Heat shock modulates neutrophil motility in zebrafish. (Lam PY, Harvie EA, Huttenlocher A) PLoS One 2013;8(12):e84436 PMID: 24367659 PMCID: PMC3868611 SCOPUS ID: 2-s2.0-84893180470 12/25/2013       23 Citations
  • odd-skipped related 2 is required for fin chondrogenesis in zebrafish. (Lam PY, Kamei CN, Mangos S, Mudumana S, Liu Y, Drummond IA) Dev Dyn 2013 Nov;242(11):1284-92 PMID: 23913342 PMCID: PMC4041527 SCOPUS ID: 2-s2.0-84886234377 08/06/2013       8 Citations
  • Interstitial leukocyte migration in vivo. (Lam PY, Huttenlocher A) Curr Opin Cell Biol 2013 Oct;25(5):650-8 PMID: 23797028 PMCID: PMC3782709 SCOPUS ID: 2-s2.0-84882926459 06/26/2013       29 Citations
  • The role of microtubules in neutrophil polarity and migration in live zebrafish. (Yoo SK, Lam PY, Eichelberg MR, Zasadil L, Bement WM, Huttenlocher A) J Cell Sci 2012 Dec 01;125(Pt 23):5702-10 PMID: 22992461 PMCID: PMC3575705 SCOPUS ID: 2-s2.0-84874698036 09/21/2012       64 Citations
  • The SH2-domain-containing inositol 5-phosphatase (SHIP) limits the motility of neutrophils and their recruitment to wounds in zebrafish. (Lam PY, Yoo SK, Green JM, Huttenlocher A) J Cell Sci 2012 Nov 01;125(Pt 21):4973-8 PMID: 22946052 PMCID: PMC3533387 SCOPUS ID: 2-s2.0-84872254649 09/05/2012       39 Citations
  • The ADPKD genes pkd1a/b and pkd2 regulate extracellular matrix formation. (Mangos S, Lam PY, Zhao A, Liu Y, Mudumana S, Vasilyev A, Liu A, Drummond IA) Dis Model Mech 2010;3(5-6):354-65 PMID: 20335443 PMCID: PMC2860853 SCOPUS ID: 2-s2.0-77952128984 03/26/2010       108 Citations
  • Erratum: Inhibition of stored Ca2+ release disrupts convergencerelated cell movements in the lateral intermediate mesoderm resulting in abnormal positioning and morphology of the pronephric anlagen in intact zebrafish embryos (Development Growth and Differentiation (2009) 51 (429442)) (Lam PY, Webb SE, Leclerc C, Moreau M, Miller AL) Development Growth and Differentiation June 2009;51(5):520 SCOPUS ID: 2-s2.0-66949148362 06/01/2009    
  • Inhibition of stored Ca2+ release disrupts convergence-related cell movements in the lateral intermediate mesoderm resulting in abnormal positioning and morphology of the pronephric anlagen in intact zebrafish embryos. (Lam PY, Webb SE, Leclerc C, Moreau M, Miller AL) Dev Growth Differ 2009 May;51(4):429-42 PMID: 19382938 SCOPUS ID: 2-s2.0-65349175207 04/23/2009       10 Citations
  • Collective cell migration drives morphogenesis of the kidney nephron. (Vasilyev A, Liu Y, Mudumana S, Mangos S, Lam PY, Majumdar A, Zhao J, Poon KL, Kondrychyn I, Korzh V, Drummond IA) PLoS Biol 2009 Jan 06;7(1):e9 PMID: 19127979 PMCID: PMC2613420 SCOPUS ID: 2-s2.0-58849125300 01/09/2009       155 Citations
  • Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue. (Qi J, Gong J, Zhao T, Zhao J, Lam P, Ye J, Li JZ, Wu J, Zhou HM, Li P) EMBO J 2008 Jun 04;27(11):1537-48 PMID: 18480843 PMCID: PMC2426729 SCOPUS ID: 2-s2.0-44649099112 05/16/2008       134 Citations
    • Last update: 11/06/2023