Medical College of Wisconsin
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Sandra L. Pfister PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Pharmacology

Member of the Cardiovascular Center


  • (5Z,11Z,15R)-15-Hydroxyeicosa-5,11-dien-13-ynoic acid: A stable isomer of 15(S)-HETE that retains key vasoconstrictive and antiproliferative activity. (Pfister SL, Klimko PG, Conrow RE) Prostaglandins Other Lipid Mediat 2016 Mar;123:33-9 PMID: 27117058 PMCID: PMC4893888 04/28/2016
  • Tyrosine dephosphorylation enhances the therapeutic target activity of epidermal growth factor receptor (EGFR) by disrupting its interaction with estrogen receptor (ER). (Ma S, Yin N, Qi X, Pfister SL, Zhang MJ, Ma R, Chen G) Oncotarget 2015 May 30;6(15):13320-33 PMID: 26079946 PMCID: PMC4537017 06/17/2015
  • Endothelial 12(S)-HETE vasorelaxation is mediated by thromboxane receptor inhibition in mouse mesenteric arteries. (Siangjong L, Gauthier KM, Pfister SL, Smyth EM, Campbell WB) Am J Physiol Heart Circ Physiol 2013 Feb 01;304(3):H382-92 PMID: 23203967 PMCID: PMC3774504 12/04/2012
  • Pulmonary arterial responses to reactive oxygen species are altered in newborn piglets with chronic hypoxia-induced pulmonary hypertension. (Fike CD, Aschner JL, Slaughter JC, Kaplowitz MR, Zhang Y, Pfister SL) Pediatr Res 2011 Aug;70(2):136-41 PMID: 21516056 PMCID: PMC3131458 04/26/2011
  • Role of superoxide and thromboxane receptors in acute angiotensin II-induced vasoconstriction of rabbit vessels. (Pfister SL, Nithipatikom K, Campbell WB) Am J Physiol Heart Circ Physiol 2011 Jun;300(6):H2064-71 PMID: 21460202 PMCID: PMC3119100 04/05/2011
  • Role of lipoxygenase metabolites of arachidonic acid in enhanced pulmonary artery contractions of female rabbits. (Pfister SL) Hypertension 2011 Apr;57(4):825-32 PMID: 21300669 PMCID: PMC3073701 02/09/2011
  • Vascular pharmacology of epoxyeicosatrienoic acids. (Pfister SL, Gauthier KM, Campbell WB) Adv Pharmacol 2010;60:27-59 PMID: 21081214 PMCID: PMC3373307 11/18/2010
  • Protein complex formation with heat shock protein 90 in chronic hypoxia-induced pulmonary hypertension in newborn piglets. (Fike CD, Pfister SL, Slaughter JC, Kaplowitz MR, Zhang Y, Zeng H, Frye NR, Aschner JL) Am J Physiol Heart Circ Physiol 2010 Oct;299(4):H1190-204 PMID: 20693398 PMCID: PMC2957352 08/10/2010
  • Chronic hypoxia enhances 15-lipoxygenase-mediated vasorelaxation in rabbit arteries. (Aggarwal NT, Pfister SL, Gauthier KM, Chawengsub Y, Baker JE, Campbell WB) Am J Physiol Heart Circ Physiol 2009 Mar;296(3):H678-88 PMID: 19112096 PMCID: PMC2660232 12/30/2008
  • Hypercholesterolemia enhances 15-lipoxygenase-mediated vasorelaxation and acetylcholine-induced hypotension. (Aggarwal NT, Pfister SL, Campbell WB) Arterioscler Thromb Vasc Biol 2008 Dec;28(12):2209-15 PMID: 18832753 10/04/2008
  • Characterization of endothelial thromboxane receptors in rabbit aorta. (Pfister SL) Prostaglandins Other Lipid Mediat 2008 Dec;87(1-4):54-61 PMID: 18812232 PMCID: PMC2584166 09/25/2008
  • Aortic thromboxane receptor deficiency alters vascular reactivity in cholesterol-fed rabbits. (Pfister SL) Atherosclerosis 2006 Dec;189(2):358-63 PMID: 16515789 03/07/2006
  • Cyclooxygenase-2 and an early stage of chronic hypoxia-induced pulmonary hypertension in newborn pigs. (Fike CD, Kaplowitz MR, Zhang Y, Pfister SL) J Appl Physiol (1985) 2005 Mar;98(3):1111-8; discussion 1091 PMID: 15516370 11/02/2004
  • Glibenclamide inhibits thromboxane-mediated vasoconstriction by thromboxane receptor blockade. (Pfister SL, Pratt PE, Kurian J, Campbell WB) Vascul Pharmacol 2004 Jan;40(6):285-92 PMID: 15063832 04/06/2004
  • Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism. (Carrier EJ, Kearn CS, Barkmeier AJ, Breese NM, Yang W, Nithipatikom K, Pfister SL, Campbell WB, Hillard CJ) Mol Pharmacol 2004 Apr;65(4):999-1007 PMID: 15044630 03/27/2004
  • Production of hydroxyeicosatetraenoic acids and prostaglandins by a novel rat microglial cell line. (Rademacher DJ, Kearn CS, Carrier EJ, Patel S, Delgado MA, Barkmeier A, Klick DE, Breese NM, Pfister SL, Nithipatikom K, Campbell WB, Hillard CJ) J Neuroimmunol 2004 Apr;149(1-2):130-41 PMID: 15020073 03/17/2004
  • Role of platelet microparticles in the production of thromboxane by rabbit pulmonary artery. (Pfister SL) Hypertension 2004 Feb;43(2):428-33 PMID: 14718367 01/14/2004
  • Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450. (Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB) Arch Biochem Biophys 2003 Dec 01;420(1):142-52 PMID: 14622984 11/19/2003
  • 11,12,15-Trihydroxyeicosatrienoic acid mediates ACh-induced relaxations in rabbit aorta. (Campbell WB, Spitzbarth N, Gauthier KM, Pfister SL) Am J Physiol Heart Circ Physiol 2003 Dec;285(6):H2648-56 PMID: 12907422 08/09/2003
  • Metabolism of 12-hydroperoxyeicosatetraenoic acid to vasodilatory trioxilin C3 by rabbit aorta. (Pfister SL, Spitzbarth N, Nithipatikom K, Falck JR, Campbell WB) Biochim Biophys Acta 2003 Jun 20;1622(1):6-13 PMID: 12829255 06/28/2003
  • Role of contaminating platelets in thromboxane synthesis in primary cultures of human umbilical vein endothelial cells. (Pfister SL, Hughes MJ, Rosolowsky M, Campbell WB) Prostaglandins Other Lipid Mediat 2002 Sep;70(1-2):39-49 PMID: 12428677 11/14/2002
  • Arachidonic acid metabolites and an early stage of pulmonary hypertension in chronically hypoxic newborn pigs. (Fike CD, Kaplowitz MR, Pfister SL) Am J Physiol Lung Cell Mol Physiol 2003 Feb;284(2):L316-23 PMID: 12388340 10/22/2002
  • Estrogen acutely activates prostacyclin synthesis in ovine fetal pulmonary artery endothelium. (Sherman TS, Chambliss KL, Gibson LL, Pace MC, Mendelsohn ME, Pfister SL, Shaul PW) Am J Respir Cell Mol Biol 2002 May;26(5):610-6 PMID: 11970914 04/24/2002
  • Cyclooxygenase contracting factors and altered pulmonary vascular responses in chronically hypoxic newborn pigs. (Fike CD, Pfister SL, Kaplowitz MR, Madden JA) J Appl Physiol (1985) 2002 Jan;92(1):67-74 PMID: 11744644 12/18/2001
  • Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta. (Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB) J Biol Chem 1998 Nov 20;273(47):30879-87 PMID: 9812980 11/13/1998
  • Methacholine-induced contraction of rabbit pulmonary artery: role of platelet-endothelial transcellular thromboxane synthesis. (Pfister SL, Deinhart DD, Campbell WB) Hypertension 1998 Jan;31(1 Pt 2):206-12 PMID: 9453304 02/07/1998
  • Vascular smooth muscle thromboxane A2 receptors mediate arachidonic acid-induced sudden death in rabbits. (Pfister SL, Kotulock DA, Campbell WB) Hypertension 1997 Jan;29(1 Pt 2):303-9 PMID: 9039119 01/01/1997
  • Contribution of arachidonic acid metabolites to reduced norepinephrine-induced contractions in hypercholesterolemic rabbit aortas. (Pfister SL, Campbell WB) J Cardiovasc Pharmacol 1996 Dec;28(6):784-91 PMID: 8961076 12/01/1996
  • Vasorelaxation by an endothelium-derived metabolite of arachidonic acid. (Pfister SL, Spitzbarth N, Edgemond W, Campbell WB) Am J Physiol 1996 Mar;270(3 Pt 2):H1021-30 PMID: 8780199 03/01/1996
  • Reduced pulmonary artery vasoconstriction in methacholine in cholesterol-fed rabbits. (Pfister SL, Campbell WB) Hypertension 1996 Mar;27(3 Pt 2):804-10 PMID: 8613244 03/01/1996
  • Role of endothelium-derived metabolites of arachidonic acid in enhanced pulmonary artery contractions in female rabbits. (Pfister SL, Campbell WB) Hypertension 1996 Jan;27(1):43-8 PMID: 8591886 01/01/1996
  • Decrease in vascular TxA2 receptors in a subgroup of rabbits unresponsive to a TxA2 mimetic. (Buzzard CJ, Pfister SL, Halushka PV, Campbell WB) Am J Physiol 1994 Jun;266(6 Pt 2):H2320-6 PMID: 8023992 06/01/1994
  • Endothelium-dependent contractions in rabbit pulmonary artery are mediated by thromboxane A2. (Buzzard CJ, Pfister SL, Campbell WB) Circ Res 1993 May;72(5):1023-34 PMID: 8477518 05/01/1993
  • Arachidonic acid- and acetylcholine-induced relaxations of rabbit aorta. (Pfister SL, Campbell WB) Hypertension 1992 Nov;20(5):682-9 PMID: 1330923 11/01/1992
  • Enhanced synthesis of epoxyeicosatrienoic acids by cholesterol-fed rabbit aorta. (Pfister SL, Falck JR, Campbell WB) Am J Physiol 1991 Sep;261(3 Pt 2):H843-52 PMID: 1887929 09/01/1991
  • Method of removal of aortic endothelium affects arachidonic acid metabolism and vascular reactivity. (Rosolowsky M, Pfister SL, Buja LM, Clubb FJ Jr, Campbell WB) Eur J Pharmacol 1991 Feb 14;193(3):293-300 PMID: 1905235 02/24/1991
  • Augmented vasoconstrictor responses to serotonin precede development of atherosclerosis in aorta of WHHL rabbit. (Wines PA, Schmitz JM, Pfister SL, Clubb FJ Jr, Buja LM, Willerson JT, Campbell WB) Arteriosclerosis 1989 Mar-Apr;9(2):195-202 PMID: 2647071 03/01/1989
  • Eicosapentaenoic acid alters vascular reactivity and platelet adhesion in Watanabe heritable hyperlipidemic rabbits. (Pfister SL, Rosolowsky M, Schmitz JM, Clubb FJ Jr, Campbell WB) Eur J Pharmacol 1989 Feb 14;161(1):85-9 PMID: 2542038 02/14/1989
  • Characterization of arachidonic acid metabolism in Watanabe heritable hyperlipidemic (WHHL) and New Zealand white (NZW) rabbit aortas. (Pfister SL, Schmitz JM, Willerson JT, Campbell WB) Prostaglandins 1988 Oct;36(4):515-32 PMID: 3238004 10/01/1988
  • Angiotensin II contributes to blood pressure maintenance in conscious rats treated with yohimbine. (Pfister SL, Keeton TK) Eur J Pharmacol 1988 May 10;149(3):377-80 PMID: 3409962 05/10/1988
  • The pharmacokinetic properties of yohimbine in the conscious rat. (Hubbard JW, Pfister SL, Biediger AM, Herzig TC, Keeton TK) Naunyn Schmiedebergs Arch Pharmacol 1988 May;337(5):583-7 PMID: 3412496 05/01/1988
  • The mechanism of yohimbine-induced renin release in the conscious rat. (Pfister SL, Keeton TK) Naunyn Schmiedebergs Arch Pharmacol 1988 Jan;337(1):35-46 PMID: 3285225 01/01/1988
  • Yohimbine induces sympathetically mediated renin release in the conscious rat. (Pfister SL, Keeton TK) Eur J Pharmacol 1984 Jan 27;97(3-4):247-55 PMID: 6323192 01/27/1984
  • Last update: 02/08/2017
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