Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Scott Terhune PhD

Scott Terhune PhD profile photo picture


Institution: Medical College of Wisconsin
Department: Microbiology and Immunology

Member of the Center for Immunology

I am willing to mentor a junior faculty member.
I am willing to collaborate on research projects.

Research Experience

  • Antiviral Agents
  • Cell Cycle
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cytomegalovirus
  • Histone Acetyltransferases
  • Histone Deacetylases
  • Host-Pathogen Interactions
  • Protein Kinases
  • STAT3 Transcription Factor
  • Signal Transduction
  • Tumor Suppressor Protein p53
  • Methodologies and Techniques

  • Cell Cycle
  • DNA, Viral
  • Drug Synergism
  • Protein Interaction Mapping
  • Proteomics
  • RNA, Viral
  • Virus Replication
  • Leadership Positions

  • Dept Representative, Faculty Council
  • Program Representative, IDP Executive Evaluation Committee
  • Past Chair, Faculty Career Development Committee
  • SOM and Graduate School Rank Committees
  • Vice Chair, Institutional Biosafety Committee
  • Publications (51)

  • Downregulation of neurodevelopmental gene expression in iPSC-derived cerebral organoids upon infection by human cytomegalovirus (O'Brien BS, Mokry RL, Schumacher ML, Pulakanti K, Rao S, Terhune SS, Ebert AD) iScience 15 April 2022;25(4) SCOPUS ID: 2-s2.0-85127531399 04/15/2022    
  • Method to Study Adaptive NK Cells Following MCMV Infections. (Khalil M, Mei A, Hashemi E, Wang D, Schumacher M, Terhune S, Malarkannan S) Methods Mol Biol 2022;2463:195-204 PMID: 35344176 SCOPUS ID: 2-s2.0-85127680170 03/29/2022    
  • Human cytomegalovirus lytic infection inhibits replication-dependent histone synthesis and requires stem loop binding protein function. (Albright ER, Morrison K, Ranganathan P, Carter DM, Nishikiori M, Lee JH, Slayton MD, Ahlquist P, Terhune SS, Kalejta RF) Proc Natl Acad Sci U S A 2022 04 05;119(14):e2122174119 PMID: 35344424 SCOPUS ID: 2-s2.0-85127264685 03/29/2022    
  • Crosstalk between Plk1, p53, cell cycle, and G2/M DNA damage checkpoint regulation in cancer: computational modeling and analysis. (Jung Y, Kraikivski P, Shafiekhani S, Terhune SS, Dash RK) NPJ Syst Biol Appl 2021 12 09;7(1):46 PMID: 34887439 PMCID: PMC8660825 SCOPUS ID: 2-s2.0-85121043614 12/11/2021       1 Citation
  • Implications of a 'Third Signal' in NK Cells. (Khalil M, Wang D, Hashemi E, Terhune SS, Malarkannan S) Cells 2021 07 31;10(8) PMID: 34440725 PMCID: PMC8393955 SCOPUS ID: 2-s2.0-85115044374 08/28/2021       1 Citation
  • MyD88 is an essential regulator of NK cell-mediated clearance of MCMV infection. (Dixon KJ, Siebert JR, Wang D, Abel AM, Johnson KE, Riese MJ, Terhune SS, Tarakanova VL, Thakar MS, Malarkannan S) Mol Immunol 2021 09;137:94-104 PMID: 34242922 SCOPUS ID: 2-s2.0-85109126048 07/10/2021    
  • Nitric Oxide Circumvents Virus-Mediated Metabolic Regulation during Human Cytomegalovirus Infection. (Mokry RL, Schumacher ML, Hogg N, Terhune SS) mBio 2020 12 15;11(6) PMID: 33323506 PMCID: PMC7773989 SCOPUS ID: 2-s2.0-85098068781 12/17/2020       4 Citations
  • Prospects for Clinical Development of Stat5 Inhibitor IST5-002: High Transcriptomic Specificity in Prostate Cancer and Low Toxicity In Vivo. (Maranto C, Udhane V, Jia J, Verma R, Müller-Newen G, LaViolette PS, Pereckas M, Sabharwal L, Terhune S, Pattabiraman N, Njar VCO, Imig JD, Wang L, Nevalainen MT) Cancers (Basel) 2020 Nov 18;12(11) PMID: 33217941 PMCID: PMC7724566 SCOPUS ID: 2-s2.0-85096199725 11/22/2020       1 Citation
  • Nitric oxide circumvents virus-mediated metabolic regulation during human cytomegalovirus infection (Mokry RL, Schumacher ML, Hogg N, Terhune SS) mBio November-December 2020;11(6):1-25 SCOPUS ID: 2-s2.0-85098068781 11/01/2020       4 Citations
  • Network mechanisms and dysfunction within an integrated computational model of progression through mitosis in the human cell cycle. (Terhune SS, Jung Y, Cataldo KM, Dash RK) PLoS Comput Biol 2020 04;16(4):e1007733 PMID: 32251461 PMCID: PMC7162553 SCOPUS ID: 2-s2.0-85083620688 04/07/2020       3 Citations
  • Erratum for Rak et al., "Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency". (Rak MA, Buehler J, Zeltzer S, Reitsma J, Molina B, Terhune S, Goodrum F) J Virol 2020 03 17;94(7) PMID: 32184335 PMCID: PMC7081901 SCOPUS ID: 2-s2.0-85082001595 03/19/2020    
  • Human Cytomegalovirus Disruption of Calcium Signaling in Neural Progenitor Cells and Organoids. (Sison SL, O'Brien BS, Johnson AJ, Seminary ER, Terhune SS, Ebert AD) J Virol 2019 09 01;93(17) PMID: 31217241 PMCID: PMC6694809 SCOPUS ID: 2-s2.0-85071355135 06/21/2019       22 Citations
  • Tumor Necrosis Factor Alpha Induces Reactivation of Human Cytomegalovirus Independently of Myeloid Cell Differentiation following Posttranscriptional Establishment of Latency. (Forte E, Swaminathan S, Schroeder MW, Kim JY, Terhune SS, Hummel M) mBio 2018 09 11;9(5) PMID: 30206173 PMCID: PMC6134100 SCOPUS ID: 2-s2.0-85055538738 09/13/2018       24 Citations
  • Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency. (Rak MA, Buehler J, Zeltzer S, Reitsma J, Molina B, Terhune S, Goodrum F) J Virol 2018 10 15;92(20) PMID: 30089695 PMCID: PMC6158428 SCOPUS ID: 2-s2.0-85052151483 08/10/2018       19 Citations
  • Isomer-specific effect of microRNA miR-29b on nuclear morphology. (Kriegel AJ, Terhune SS, Greene AS, Noon KR, Pereckas MS, Liang M) J Biol Chem 2018 09 07;293(36):14080-14088 PMID: 30006350 PMCID: PMC6130969 SCOPUS ID: 2-s2.0-85053013199 07/15/2018       8 Citations
  • Association of Mycobacterium Proteins with Lipid Droplets. (Armstrong RM, Carter DC, Atkinson SN, Terhune SS, Zahrt TC) J Bacteriol 2018 08 15;200(16) PMID: 29760207 PMCID: PMC6060360 SCOPUS ID: 2-s2.0-85050494395 05/16/2018       9 Citations
  • Impact of RNA polymerase I inhibitor CX-5461 on viral kinase-dependent and -independent cytomegalovirus replication. (Westdorp KN, Terhune SS) Antiviral Res 2018 05;153:33-38 PMID: 29458130 PMCID: PMC6015744 SCOPUS ID: 2-s2.0-85043578832 02/20/2018       8 Citations
  • Correction for Mounce et al., "A Conserved Gammaherpesvirus Protein Kinase Targets Histone Deacetylases 1 and 2 To Facilitate Viral Replication in Primary Macrophages". (Mounce BC, Mboko WP, Bigley TM, Terhune SS, Tarakanova VL) J Virol 2018 01 01;92(1) PMID: 29242252 PMCID: PMC5730793 SCOPUS ID: 2-s2.0-85037989790 12/16/2017    
  • SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression. (Gonyo P, Bergom C, Brandt AC, Tsaih SW, Sun Y, Bigley TM, Lorimer EL, Terhune SS, Rui H, Flister MJ, Long RM, Williams CL) Oncogene 2017 12 14;36(50):6873-6883 PMID: 28806394 PMCID: PMC5730474 SCOPUS ID: 2-s2.0-85038242723 08/15/2017       9 Citations
  • Cytomegalovirus Late Protein pUL31 Alters Pre-rRNA Expression and Nuclear Organization during Infection. (Westdorp KN, Sand A, Moorman NJ, Terhune SS) J Virol 2017 09 15;91(18) PMID: 28659485 PMCID: PMC5571270 SCOPUS ID: 2-s2.0-85028302530 07/01/2017       9 Citations
  • Proteomic Screen for Cellular Targets of the Vaccinia Virus F10 Protein Kinase Reveals that Phosphorylation of mDia Regulates Stress Fiber Formation. (Greseth MD, Carter DC, Terhune SS, Traktman P) Mol Cell Proteomics 2017 04;16(4 suppl 1):S124-S143 PMID: 28183815 PMCID: PMC5393388 SCOPUS ID: 2-s2.0-85017129288 02/12/2017       8 Citations
  • Opposing Regulation of the EGF Receptor: A Molecular Switch Controlling Cytomegalovirus Latency and Replication. (Buehler J, Zeltzer S, Reitsma J, Petrucelli A, Umashankar M, Rak M, Zagallo P, Schroeder J, Terhune S, Goodrum F) PLoS Pathog 2016 05;12(5):e1005655 PMID: 27218650 PMCID: PMC4878804 SCOPUS ID: 2-s2.0-84973327135 05/25/2016       63 Citations
  • Impact of a cytomegalovirus kinase inhibitor on infection and neuronal progenitor cell differentiation. (Bigley TM, McGivern JV, Ebert AD, Terhune SS) Antiviral Res 2016 May;129:67-73 PMID: 26875788 PMCID: PMC4957402 SCOPUS ID: 2-s2.0-84959527703 02/16/2016       3 Citations
  • Antagonistic Relationship between Human Cytomegalovirus pUL27 and pUL97 Activities during Infection. (Bigley TM, Reitsma JM, Terhune SS) J Virol 2015 Oct;89(20):10230-46 PMID: 26223645 PMCID: PMC4580190 SCOPUS ID: 2-s2.0-84942155947 08/01/2015       13 Citations
  • Targeted analysis of recombinant NF kappa B (RelA/p65) by denaturing and native top down mass spectrometry. (Savaryn JP, Skinner OS, Fornelli L, Fellers RT, Compton PD, Terhune SS, Abecassis MM, Kelleher NL) J Proteomics 2016 Feb 16;134:76-84 PMID: 25952688 PMCID: PMC4633404 SCOPUS ID: 2-s2.0-84958173605 05/09/2015       11 Citations
  • Proteomic identification of nuclear processes manipulated by cytomegalovirus early during infection. (Carter DM, Westdorp K, Noon KR, Terhune SS) Proteomics 2015 Jun;15(12):1995-2005 PMID: 25758553 PMCID: PMC4556115 SCOPUS ID: 2-s2.0-84931005724 03/12/2015       7 Citations
  • The MprB extracytoplasmic domain negatively regulates activation of the Mycobacterium tuberculosis MprAB two-component system. (Bretl DJ, Bigley TM, Terhune SS, Zahrt TC) J Bacteriol 2014 Jan;196(2):391-406 PMID: 24187094 PMCID: PMC3911260 SCOPUS ID: 2-s2.0-84890919033 11/05/2013       19 Citations
  • Inhibition of cellular STAT3 synergizes with the cytomegalovirus kinase inhibitor maribavir to disrupt infection. (Reitsma JM, Terhune SS) Antiviral Res 2013 Nov;100(2):321-7 PMID: 24070820 PMCID: PMC3845884 SCOPUS ID: 2-s2.0-84885352457 09/28/2013       9 Citations
  • Discovery of host-viral protein complexes during infection. (Rowles DL, Terhune SS, Cristea IM) Methods Mol Biol 2013;1064:43-70 PMID: 23996249 PMCID: PMC4162421 SCOPUS ID: 2-s2.0-84884176527 09/03/2013       13 Citations
  • Human cytomegalovirus IE1 protein disrupts interleukin-6 signaling by sequestering STAT3 in the nucleus. (Reitsma JM, Sato H, Nevels M, Terhune SS, Paulus C) J Virol 2013 Oct;87(19):10763-76 PMID: 23903834 PMCID: PMC3807375 SCOPUS ID: 2-s2.0-84886016486 08/02/2013       41 Citations
  • A conserved gammaherpesvirus protein kinase targets histone deacetylases 1 and 2 to facilitate viral replication in primary macrophages. (Mounce BC, Mboko WP, Bigley TM, Terhune SS, Tarakanova VL) J Virol 2013 Jul;87(13):7314-25 PMID: 23616648 PMCID: PMC3700300 SCOPUS ID: 2-s2.0-84880360676 04/26/2013       11 Citations
  • Human cytomegalovirus pUL97 regulates the viral major immediate early promoter by phosphorylation-mediated disruption of histone deacetylase 1 binding. (Bigley TM, Reitsma JM, Mirza SP, Terhune SS) J Virol 2013 Jul;87(13):7393-408 PMID: 23616659 PMCID: PMC3700266 SCOPUS ID: 2-s2.0-84880367640 04/26/2013       23 Citations
  • Human cytomegalovirus pUL29/28 and pUL38 repression of p53-regulated p21CIP1 and caspase 1 promoters during infection. (Savaryn JP, Reitsma JM, Bigley TM, Halligan BD, Qian Z, Yu D, Terhune SS) J Virol 2013 Mar;87(5):2463-74 PMID: 23236067 PMCID: PMC3571358 SCOPUS ID: 2-s2.0-84874743912 12/14/2012       22 Citations
  • A method for quantifying mechanical properties of tissue following viral infection. (Lam V, Bigley T, Terhune SS, Wakatsuki T) PLoS One 2012;7(8):e42197 PMID: 22870300 PMCID: PMC3411685 SCOPUS ID: 2-s2.0-84864560232 08/08/2012       5 Citations
  • Proteasome-dependent disruption of the E3 ubiquitin ligase anaphase-promoting complex by HCMV protein pUL21a. (Fehr AR, Gualberto NC, Savaryn JP, Terhune SS, Yu D) PLoS Pathog 2012;8(7):e1002789 PMID: 22792066 PMCID: PMC3390409 SCOPUS ID: 2-s2.0-84864614340 07/14/2012       24 Citations
  • Ubiquitin and ubiquitin-modified proteins activate the Pseudomonas aeruginosa T3SS cytotoxin, ExoU. (Anderson DM, Schmalzer KM, Sato H, Casey M, Terhune SS, Haas AL, Feix JB, Frank DW) Mol Microbiol 2011 Dec;82(6):1454-67 PMID: 22040088 PMCID: PMC3237844 SCOPUS ID: 2-s2.0-83355166268 11/02/2011       61 Citations
  • The HtrA-like serine protease PepD interacts with and modulates the Mycobacterium tuberculosis 35-kDa antigen outer envelope protein. (White MJ, Savaryn JP, Bretl DJ, He H, Penoske RM, Terhune SS, Zahrt TC) PLoS One 2011 Mar 22;6(3):e18175 PMID: 21445360 PMCID: PMC3062566 SCOPUS ID: 2-s2.0-79952927866 03/30/2011       37 Citations
  • Antiviral inhibition targeting the HCMV kinase pUL97 requires pUL27-dependent degradation of Tip60 acetyltransferase and cell-cycle arrest. (Reitsma JM, Savaryn JP, Faust K, Sato H, Halligan BD, Terhune SS) Cell Host Microbe 2011 Feb 17;9(2):103-14 PMID: 21320693 SCOPUS ID: 2-s2.0-79951592516 02/16/2011       53 Citations
  • Human cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNA. (Terhune SS, Moorman NJ, Cristea IM, Savaryn JP, Cuevas-Bennett C, Rout MP, Chait BT, Shenk T) PLoS Pathog 2010 Jun 24;6(6):e1000965 PMID: 20585571 PMCID: PMC2891856 SCOPUS ID: 2-s2.0-77954671476 06/30/2010       57 Citations
  • Human cytomegalovirus pUL83 stimulates activity of the viral immediate-early promoter through its interaction with the cellular IFI16 protein. (Cristea IM, Moorman NJ, Terhune SS, Cuevas CD, O'Keefe ES, Rout MP, Chait BT, Shenk T) J Virol 2010 Aug;84(15):7803-14 PMID: 20504932 PMCID: PMC2897612 SCOPUS ID: 2-s2.0-77954485440 05/28/2010       129 Citations
  • Human cytomegalovirus UL28 and UL29 open reading frames encode a spliced mRNA and stimulate accumulation of immediate-early RNAs. (Mitchell DP, Savaryn JP, Moorman NJ, Shenk T, Terhune SS) J Virol 2009 Oct;83(19):10187-97 PMID: 19625400 PMCID: PMC2748044 SCOPUS ID: 2-s2.0-70349290582 07/25/2009       30 Citations
  • Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complex. (Moorman NJ, Cristea IM, Terhune SS, Rout MP, Chait BT, Shenk T) Cell Host Microbe 2008 Apr 17;3(4):253-62 PMID: 18407068 PMCID: PMC2759192 SCOPUS ID: 2-s2.0-41849101685 04/15/2008       153 Citations
  • Human cytomegalovirus UL38 protein blocks apoptosis. (Terhune S, Torigoi E, Moorman N, Silva M, Qian Z, Shenk T, Yu D) J Virol 2007 Apr;81(7):3109-23 PMID: 17202209 PMCID: PMC1866066 SCOPUS ID: 2-s2.0-33947399734 01/05/2007       119 Citations
  • RNAs are packaged into human cytomegalovirus virions in proportion to their intracellular concentration. (Terhune SS, Schröer J, Shenk T) J Virol 2004 Oct;78(19):10390-8 PMID: 15367605 PMCID: PMC516422 SCOPUS ID: 2-s2.0-4544262244 09/16/2004       69 Citations
  • Differential outcomes of human cytomegalovirus infection in primitive hematopoietic cell subpopulations. (Goodrum F, Jordan CT, Terhune SS, High K, Shenk T) Blood 2004 Aug 01;104(3):687-95 PMID: 15090458 SCOPUS ID: 2-s2.0-3242780176 04/20/2004       115 Citations
  • Early polyadenylation signals of human papillomavirus type 31 negatively regulate capsid gene expression. (Terhune SS, Hubert WG, Thomas JT, Laimins LA) J Virol 2001 Sep;75(17):8147-57 PMID: 11483760 PMCID: PMC115059 SCOPUS ID: 2-s2.0-0034872763 08/03/2001       37 Citations
  • Cellular changes induced by low-risk human papillomavirus type 11 in keratinocytes that stably maintain viral episomes. (Thomas JT, Oh ST, Terhune SS, Laimins LA) J Virol 2001 Aug;75(16):7564-71 PMID: 11462028 PMCID: PMC114991 SCOPUS ID: 2-s2.0-0034897704 07/20/2001       47 Citations
  • Regulation of human papillomavirus type 31 polyadenylation during the differentiation-dependent life cycle. (Terhune SS, Milcarek C, Laimins LA) J Virol 1999 Sep;73(9):7185-92 PMID: 10438805 PMCID: PMC104242 SCOPUS ID: 2-s2.0-0032815839 08/10/1999       42 Citations
  • Limited variability of glycoprotein gene sequences and neutralizing targets in herpes simplex virus type 2 isolates and stability on passage in cell culture. (Terhune SS, Coleman KT, Sekulovich R, Burke RL, Spear PG) J Infect Dis 1998 Jul;178(1):8-15 PMID: 9652417 SCOPUS ID: 2-s2.0-0031868159 07/04/1998       37 Citations
  • Viral determinants of the variable sensitivity of herpes simplex virus strains to gD-mediated interference. (Dean HJ, Warner MS, Terhune SS, Johnson RM, Spear PG) J Virol 1995 Aug;69(8):5171-6 PMID: 7609090 PMCID: PMC189341 SCOPUS ID: 2-s2.0-0029058864 08/01/1995       23 Citations
  • Single amino acid substitutions in gD of herpes simplex virus 1 confer resistance to gD-mediated interference and cause cell-type-dependent alterations in infectivity. (Dean HJ, Terhune SS, Shieh MT, Susmarski N, Spear PG) Virology 1994 Feb 15;199(1):67-80 PMID: 8116256 SCOPUS ID: 2-s2.0-0028245995 02/15/1994       87 Citations
  • Last update: 04/20/2022