Medical College of Wisconsin
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Scott Terhune PhD

Scott Terhune PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Microbiology and Immunology

Member of the Cancer Center

I am willing to mentor a junior faculty member.


  • Cytomegalovirus Late Protein pUL31 Alters Pre-rRNA Expression and Nuclear Organization during Infection. (Westdorp KN, Sand A, Moorman NJ, Terhune SS) J Virol 2017 Sep 15;91(18) PMID: 28659485 PMCID: PMC5571270 07/01/2017
  • Proteomic Screen for Cellular Targets of the Vaccinia Virus F10 Protein Kinase Reveals that Phosphorylation of mDia Regulates Stress Fiber Formation. (Greseth MD, Carter DC, Terhune SS, Traktman P) Mol Cell Proteomics 2017 Apr;16(4 suppl 1):S124-S143 PMID: 28183815 PMCID: PMC5393388 02/12/2017
  • Opposing Regulation of the EGF Receptor: A Molecular Switch Controlling Cytomegalovirus Latency and Replication. (Buehler J, Zeltzer S, Reitsma J, Petrucelli A, Umashankar M, Rak M, Zagallo P, Schroeder J, Terhune S, Goodrum F) PLoS Pathog 2016 May;12(5):e1005655 PMID: 27218650 PMCID: PMC4878804 05/25/2016
  • Impact of a cytomegalovirus kinase inhibitor on infection and neuronal progenitor cell differentiation. (Bigley TM, McGivern JV, Ebert AD, Terhune SS) Antiviral Res 2016 May;129:67-73 PMID: 26875788 PMCID: PMC4957402 02/16/2016
  • Antagonistic Relationship between Human Cytomegalovirus pUL27 and pUL97 Activities during Infection. (Bigley TM, Reitsma JM, Terhune SS) J Virol 2015 Oct;89(20):10230-46 PMID: 26223645 PMCID: PMC4580190 08/01/2015
  • Targeted analysis of recombinant NF kappa B (RelA/p65) by denaturing and native top down mass spectrometry. (Savaryn JP, Skinner OS, Fornelli L, Fellers RT, Compton PD, Terhune SS, Abecassis MM, Kelleher NL) J Proteomics 2016 Feb 16;134:76-84 PMID: 25952688 PMCID: PMC4633404 05/09/2015
  • Proteomic identification of nuclear processes manipulated by cytomegalovirus early during infection. (Carter DM, Westdorp K, Noon KR, Terhune SS) Proteomics 2015 Jun;15(12):1995-2005 PMID: 25758553 PMCID: PMC4556115 03/12/2015
  • The MprB extracytoplasmic domain negatively regulates activation of the Mycobacterium tuberculosis MprAB two-component system. (Bretl DJ, Bigley TM, Terhune SS, Zahrt TC) J Bacteriol 2014 Jan;196(2):391-406 PMID: 24187094 PMCID: PMC3911260 11/05/2013
  • Inhibition of cellular STAT3 synergizes with the cytomegalovirus kinase inhibitor maribavir to disrupt infection. (Reitsma JM, Terhune SS) Antiviral Res 2013 Nov;100(2):321-7 PMID: 24070820 PMCID: PMC3845884 09/28/2013
  • Discovery of host-viral protein complexes during infection. (Rowles DL, Terhune SS, Cristea IM) Methods Mol Biol 2013;1064:43-70 PMID: 23996249 PMCID: PMC4162421 09/03/2013
  • Human cytomegalovirus IE1 protein disrupts interleukin-6 signaling by sequestering STAT3 in the nucleus. (Reitsma JM, Sato H, Nevels M, Terhune SS, Paulus C) J Virol 2013 Oct;87(19):10763-76 PMID: 23903834 PMCID: PMC3807375 08/02/2013
  • A conserved gammaherpesvirus protein kinase targets histone deacetylases 1 and 2 to facilitate viral replication in primary macrophages. (Mounce BC, Mboko WP, Bigley TM, Terhune SS, Tarakanova VL) J Virol 2013 Jul;87(13):7314-25 PMID: 23616648 PMCID: PMC3700300 04/26/2013
  • Human cytomegalovirus pUL97 regulates the viral major immediate early promoter by phosphorylation-mediated disruption of histone deacetylase 1 binding. (Bigley TM, Reitsma JM, Mirza SP, Terhune SS) J Virol 2013 Jul;87(13):7393-408 PMID: 23616659 PMCID: PMC3700266 04/26/2013
  • Human cytomegalovirus pUL29/28 and pUL38 repression of p53-regulated p21CIP1 and caspase 1 promoters during infection. (Savaryn JP, Reitsma JM, Bigley TM, Halligan BD, Qian Z, Yu D, Terhune SS) J Virol 2013 Mar;87(5):2463-74 PMID: 23236067 PMCID: PMC3571358 12/14/2012
  • A method for quantifying mechanical properties of tissue following viral infection. (Lam V, Bigley T, Terhune SS, Wakatsuki T) PLoS One 2012;7(8):e42197 PMID: 22870300 PMCID: PMC3411685 08/08/2012
  • Proteasome-dependent disruption of the E3 ubiquitin ligase anaphase-promoting complex by HCMV protein pUL21a. (Fehr AR, Gualberto NC, Savaryn JP, Terhune SS, Yu D) PLoS Pathog 2012;8(7):e1002789 PMID: 22792066 PMCID: PMC3390409 07/14/2012
  • Ubiquitin and ubiquitin-modified proteins activate the Pseudomonas aeruginosa T3SS cytotoxin, ExoU. (Anderson DM, Schmalzer KM, Sato H, Casey M, Terhune SS, Haas AL, Feix JB, Frank DW) Mol Microbiol 2011 Dec;82(6):1454-67 PMID: 22040088 PMCID: PMC3237844 11/02/2011
  • The HtrA-like serine protease PepD interacts with and modulates the Mycobacterium tuberculosis 35-kDa antigen outer envelope protein. (White MJ, Savaryn JP, Bretl DJ, He H, Penoske RM, Terhune SS, Zahrt TC) PLoS One 2011 Mar 22;6(3):e18175 PMID: 21445360 PMCID: PMC3062566 03/30/2011
  • Antiviral inhibition targeting the HCMV kinase pUL97 requires pUL27-dependent degradation of Tip60 acetyltransferase and cell-cycle arrest. (Reitsma JM, Savaryn JP, Faust K, Sato H, Halligan BD, Terhune SS) Cell Host Microbe 2011 Feb 17;9(2):103-14 PMID: 21320693 02/16/2011
  • Human cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNA. (Terhune SS, Moorman NJ, Cristea IM, Savaryn JP, Cuevas-Bennett C, Rout MP, Chait BT, Shenk T) PLoS Pathog 2010 Jun 24;6(6):e1000965 PMID: 20585571 PMCID: PMC2891856 06/30/2010
  • Human cytomegalovirus pUL83 stimulates activity of the viral immediate-early promoter through its interaction with the cellular IFI16 protein. (Cristea IM, Moorman NJ, Terhune SS, Cuevas CD, O'Keefe ES, Rout MP, Chait BT, Shenk T) J Virol 2010 Aug;84(15):7803-14 PMID: 20504932 PMCID: PMC2897612 05/28/2010
  • Human cytomegalovirus UL28 and UL29 open reading frames encode a spliced mRNA and stimulate accumulation of immediate-early RNAs. (Mitchell DP, Savaryn JP, Moorman NJ, Shenk T, Terhune SS) J Virol 2009 Oct;83(19):10187-97 PMID: 19625400 PMCID: PMC2748044 07/25/2009
  • Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complex. (Moorman NJ, Cristea IM, Terhune SS, Rout MP, Chait BT, Shenk T) Cell Host Microbe 2008 Apr 17;3(4):253-62 PMID: 18407068 PMCID: PMC2759192 04/15/2008
  • Human cytomegalovirus UL38 protein blocks apoptosis. (Terhune S, Torigoi E, Moorman N, Silva M, Qian Z, Shenk T, Yu D) J Virol 2007 Apr;81(7):3109-23 PMID: 17202209 PMCID: PMC1866066 01/05/2007
  • RNAs are packaged into human cytomegalovirus virions in proportion to their intracellular concentration. (Terhune SS, Schröer J, Shenk T) J Virol 2004 Oct;78(19):10390-8 PMID: 15367605 PMCID: PMC516422 09/16/2004
  • Differential outcomes of human cytomegalovirus infection in primitive hematopoietic cell subpopulations. (Goodrum F, Jordan CT, Terhune SS, High K, Shenk T) Blood 2004 Aug 01;104(3):687-95 PMID: 15090458 04/20/2004
  • Early polyadenylation signals of human papillomavirus type 31 negatively regulate capsid gene expression. (Terhune SS, Hubert WG, Thomas JT, Laimins LA) J Virol 2001 Sep;75(17):8147-57 PMID: 11483760 PMCID: PMC115059 08/03/2001
  • Cellular changes induced by low-risk human papillomavirus type 11 in keratinocytes that stably maintain viral episomes. (Thomas JT, Oh ST, Terhune SS, Laimins LA) J Virol 2001 Aug;75(16):7564-71 PMID: 11462028 PMCID: PMC114991 07/20/2001
  • Regulation of human papillomavirus type 31 polyadenylation during the differentiation-dependent life cycle. (Terhune SS, Milcarek C, Laimins LA) J Virol 1999 Sep;73(9):7185-92 PMID: 10438805 PMCID: PMC104242 08/10/1999
  • Limited variability of glycoprotein gene sequences and neutralizing targets in herpes simplex virus type 2 isolates and stability on passage in cell culture. (Terhune SS, Coleman KT, Sekulovich R, Burke RL, Spear PG) J Infect Dis 1998 Jul;178(1):8-15 PMID: 9652417 07/04/1998
  • Viral determinants of the variable sensitivity of herpes simplex virus strains to gD-mediated interference. (Dean HJ, Warner MS, Terhune SS, Johnson RM, Spear PG) J Virol 1995 Aug;69(8):5171-6 PMID: 7609090 PMCID: PMC189341 08/01/1995
  • Single amino acid substitutions in gD of herpes simplex virus 1 confer resistance to gD-mediated interference and cause cell-type-dependent alterations in infectivity. (Dean HJ, Terhune SS, Shieh MT, Susmarski N, Spear PG) Virology 1994 Feb 15;199(1):67-80 PMID: 8116256 02/15/1994
  • Last update: 07/05/2017
    jenkins-FCD Prod-130 96200611f8481f0aa4f84230b11dd74d063847a3