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Shekar N. Kurpad MD, PhD

Shekar N. Kurpad MD, PhD

Chair, Professor

Institution: Medical College of Wisconsin
Department: Neurosurgery
Program: Administration

Member of the Neuroscience Research Center
Member of the Comprehensive Injury Center


Publications

  • Emerging Safety of Intramedullary Transplantation of Human Neural Stem Cells in Chronic Cervical and Thoracic Spinal Cord Injury. (Levi AD, Okonkwo DO, Park P, Jenkins AL 3rd, Kurpad SN, Parr AM, Ganju A, Aarabi B, Kim D, Casha S, Fehlings MG, Harrop JS, Anderson KD, Gage A, Hsieh J, Huhn S, Curt A, Guzman R) Neurosurgery 2017 May 24 PMID: 28541431 05/26/2017
  • Acute death of astrocytes in blast-exposed rat organotypic hippocampal slice cultures. (Miller AP, Shah AS, Aperi BV, Kurpad SN, Stemper BD, Glavaski-Joksimovic A) PLoS One 2017;12(3):e0173167 PMID: 28264063 PMCID: PMC5338800 03/07/2017
  • 177 Largest Series of Mild-Moderate Motor Vehicle Accident-Associated Thoracolumbar Compression Fractures: Prognosis and Outcome. (Soliman HM, Nguyen H, Pintar FA, Yoganandan N, Kurpad SN, Maiman DJ) Neurosurgery 2016 Aug 01;63(CN_suppl_1):170-171 PMID: 28175437 02/09/2017
  • Spinal Diffusion Tensor Imaging in Evaluation of Preoperative and Postoperative Severity of Cervical Spondylotic Myelopathy: Systematic Review of Literature. (Rindler RS, Chokshi FH, Malcolm JG, Eshraghi SR, Mossa-Basha M, Chu JK, Kurpad SN, Ahmad FU) World Neurosurg 2017 Mar;99:150-158 PMID: 27939797 12/13/2016
  • Evaluation of Whole-Brain Resting-State Functional Connectivity in Spinal Cord Injury: A Large-Scale Network Analysis Using Network-Based Statistic. (Kaushal M, Oni-Orisan A, Chen G, Li W, Leschke J, Ward BD, Kalinosky B, Budde MD, Schmit BD, Li SJ, Muqeet V, Kurpad SN) J Neurotrauma 2017 Mar 15;34(6):1278-1282 PMID: 27937140 12/13/2016
  • Prediction of Post-Concussive Behavioral Changes in a Rodent Model Based on Head Rotational Acceleration Characteristics. (Stemper BD, Shah AS, Chiariello R, Olsen CM, Budde MD, Glavaski-Joksimovic A, McCrea M, Kurpad SN, Pintar FA) Ann Biomed Eng 2016 Nov;44(11):3252-3265 PMID: 27188340 PMCID: PMC5093216 11/04/2016
  • Diffusion tensor imaging as a biomarker for assessing neuronal stem cell treatments affecting areas distal to the site of spinal cord injury. (Jirjis MB, Valdez C, Vedantam A, Schmit BD, Kurpad SN) J Neurosurg Spine 2017 Feb;26(2):243-251 PMID: 27689421 10/01/2016
  • 177 Largest Series of Mild-Moderate Motor Vehicle Accident-Associated Thoracolumbar Compression Fractures: Prognosis and Outcome. (Soliman HM, Nguyen H, Pintar FA, Yoganandan N, Kurpad SN, Maiman DJ) Neurosurgery 2016 Aug;63 Suppl 1:170-1 PMID: 27399456 07/12/2016
  • 181 Guidelines for the Management of Patients With Spinal Cord Injury: The Optimal Timing of Decompression. (Wilson JR, BSc LT, Aarabi B, Anderson PA, Arnold PM, Brodke DS, Burns A, Chen R, Chiba K, Dettori J, Furlan JC, Harrop JS, Holly LT, Jeji T, Kalsi-Ryan S, Kotter M, Kurpad SN, Kwon BK, Marino R, Martin AR, Massicotte EM, Merli G, Middleton J, Nakashima H, Nagoshi N, Palmieri K, Shamji MF, Singh A, Skelly A, Yee A, Fehlings M) Neurosurgery 2016 Aug;63 Suppl 1:172 PMID: 27399460 07/12/2016
  • Rapid in vivo detection of rat spinal cord injury with double-diffusion-encoded magnetic resonance spectroscopy. (Skinner NP, Kurpad SN, Schmit BD, Tugan Muftuler L, Budde MD) Magn Reson Med 2017 Apr;77(4):1639-1649 PMID: 27080726 PMCID: PMC5285487 04/16/2016
  • Diffusion Tensor Imaging Correlates with Short-Term Myelopathy Outcome in Patients with Cervical Spondylotic Myelopathy. (Vedantam A, Rao A, Kurpad SN, Jirjis MB, Eckardt G, Schmit BD, Wang MC) World Neurosurg 2017 Jan;97:489-494 PMID: 27046013 04/06/2016
  • Behavioral Outcomes Differ between Rotational Acceleration and Blast Mechanisms of Mild Traumatic Brain Injury. (Stemper BD, Shah AS, Budde MD, Olsen CM, Glavaski-Joksimovic A, Kurpad SN, McCrea M, Pintar FA) Front Neurol 2016;7:31 PMID: 27014184 PMCID: PMC4789366 03/26/2016
  • Alterations in Cortical Sensorimotor Connectivity following Complete Cervical Spinal Cord Injury: A Prospective Resting-State fMRI Study. (Oni-Orisan A, Kaushal M, Li W, Leschke J, Ward BD, Vedantam A, Kalinosky B, Budde MD, Schmit BD, Li SJ, Muqeet V, Kurpad SN) PLoS One 2016;11(3):e0150351 PMID: 26954693 PMCID: PMC4783046 03/10/2016
  • Syringosubarachnoid shunting using a myringotomy tube. (Leschke JM, Mumert ML, Kurpad SN) Surg Neurol Int 2016;7(Suppl 1):S8-S11 PMID: 26862456 PMCID: PMC4722522 02/11/2016
  • Detection of acute nervous system injury with advanced diffusion-weighted MRI: a simulation and sensitivity analysis. (Skinner NP, Kurpad SN, Schmit BD, Budde MD) NMR Biomed 2015 Nov;28(11):1489-506 PMID: 26411743 09/29/2015
  • Severity of spinal cord injury influences diffusion tensor imaging of the brain. (Jirjis MB, Vedantam A, Budde MD, Kalinosky B, Kurpad SN, Schmit BD) J Magn Reson Imaging 2016 Jan;43(1):63-74 PMID: 26094789 06/23/2015
  • Effects of blast overpressure on neurons and glial cells in rat organotypic hippocampal slice cultures. (Miller AP, Shah AS, Aperi BV, Budde MD, Pintar FA, Tarima S, Kurpad SN, Stemper BD, Glavaski-Joksimovic A) Front Neurol 2015;6:20 PMID: 25729377 PMCID: PMC4325926 03/03/2015
  • The cognitive and technical skills impact of the Congress of Neurological Surgeons simulation curriculum on neurosurgical trainees at the 2013 Neurological Society of India meeting. (Zammar SG, Hamade YJ, Aoun RJ, El Tecle NE, El Ahmadieh TY, Adelson PD, Kurpad SN, Harrop JS, Hodge H, Mishra RC, Rajshekhar V, Rezai AR, Sahkla SK, Sattur MG, Selden NR, Sharan AD, Resnick DK, Bendok BR) World Neurosurg 2015 Apr;83(4):419-23 PMID: 25524066 12/20/2014
  • Head rotational acceleration characteristics influence behavioral and diffusion tensor imaging outcomes following concussion. (Stemper BD, Shah AS, Pintar FA, McCrea M, Kurpad SN, Glavaski-Joksimovic A, Olsen C, Budde MD) Ann Biomed Eng 2015 May;43(5):1071-88 PMID: 25344352 PMCID: PMC4654450 10/26/2014
  • High cervical fractional anisotropy as an imaging marker for spinal cord injury. (Vedantam A, Eckardt G, Wang MC, Schmit BD, Kurpad SN) Neurosurgery 2014 Aug;61 Suppl 1:167-70 PMID: 25032546 07/18/2014
  • Diffusion tensor imaging of the spinal cord: insights from animal and human studies. (Vedantam A, Jirjis MB, Schmit BD, Wang MC, Ulmer JL, Kurpad SN) Neurosurgery 2014 Jan;74(1):1-8; discussion 8; quiz 8 PMID: 24064483 PMCID: PMC4986512 09/26/2013
  • Clinical correlates of high cervical fractional anisotropy in acute cervical spinal cord injury. (Vedantam A, Eckardt G, Wang MC, Schmit BD, Kurpad SN) World Neurosurg 2015 May;83(5):824-8 PMID: 24055569 09/24/2013
  • Ex vivo diffusion tensor imaging of spinal cord injury in rats of varying degrees of severity. (Jirjis MB, Kurpad SN, Schmit BD) J Neurotrauma 2013 Sep 15;30(18):1577-86 PMID: 23782233 PMCID: PMC3761423 06/21/2013
  • Characterization and limitations of diffusion tensor imaging metrics in the cervical spinal cord in neurologically intact subjects. (Vedantam A, Jirjis MB, Schmit BD, Wang MC, Ulmer JL, Kurpad SN) J Magn Reson Imaging 2013 Oct;38(4):861-7 PMID: 23389869 02/08/2013
  • Diffusion tensor imaging and tractography in Brown-Sequard syndrome. (Vedantam A, Jirjis MB, Schmit BD, Budde MD, Ulmer JL, Wang MC, Kurpad SN) Spinal Cord 2012 Dec;50(12):928-30 PMID: 23045298 10/10/2012
  • Evaluation of combined bevacizumab plus irinotecan therapy in brain tumors using magnetic resonance imaging measures of relative cerebral blood volume. (Pechman KR, Donohoe DL, Bedekar DP, Kurpad SN, Schmainda KM) Magn Reson Med 2012 Oct;68(4):1266-72 PMID: 22213469 PMCID: PMC3323703 01/04/2012
  • Feline bone marrow-derived mesenchymal stem cells express several pluripotent and neural markers and easily turn into neural-like cells by manipulation with chromatin modifying agents and neural inducing factors. (Zhang Z, Maiman DJ, Kurpad SN, Crowe MJ, Alexanian AR) Cell Reprogram 2011 Oct;13(5):385-90 PMID: 21718099 07/02/2011
  • Atlantooccipital dislocation in motor vehicle side impact, derivation of the mechanism of injury, and implications for early diagnosis. (Smith KM, Yoganandan N, Pintar FA, Kurpad SN, Maiman DJ) J Craniovertebr Junction Spine 2010 Jul;1(2):113-7 PMID: 21572632 PMCID: PMC3075827 05/17/2011
  • Characterization of bevacizumab dose response relationship in U87 brain tumors using magnetic resonance imaging measures of enhancing tumor volume and relative cerebral blood volume. (Pechman KR, Donohoe DL, Bedekar DP, Kurpad SN, Hoffmann RG, Schmainda KM) J Neurooncol 2011 Nov;105(2):233-9 PMID: 21533524 PMCID: PMC4323180 05/03/2011
  • High-resolution in vivo diffusion tensor imaging of the injured cat spinal cord using self-navigated, interleaved, variable-density spiral acquisition (SNAILS-DTI). (Ellingson BM, Sulaiman O, Kurpad SN) Magn Reson Imaging 2010 Nov;28(9):1353-60 PMID: 20797830 08/28/2010
  • Transplantation of human glial-restricted neural precursors into injured spinal cord promotes functional and sensory recovery without causing allodynia. (Alexanian AR, Svendsen CN, Crowe MJ, Kurpad SN) Cytotherapy 2011 Jan;13(1):61-8 PMID: 20735167 08/26/2010
  • Lesion growth and degeneration patterns measured using diffusion tensor 9.4-T magnetic resonance imaging in rat spinal cord injury. (Ellingson BM, Schmit BD, Kurpad SN) J Neurosurg Spine 2010 Aug;13(2):181-92 PMID: 20672953 08/03/2010
  • Functional correlates of diffusion tensor imaging in spinal cord injury. (Ellingson BM, Kurpad SN, Schmit BD) Biomed Sci Instrum 2008;44:28-33 PMID: 19141888 01/15/2009
  • Characteristics of mid- to long-latency spinal somatosensory evoked potentials following spinal trauma in the rat. (Ellingson BM, Kurpad SN, Schmit BD) J Neurotrauma 2008 Nov;25(11):1323-34 PMID: 18976168 11/04/2008
  • Ex vivo diffusion tensor imaging and quantitative tractography of the rat spinal cord during long-term recovery from moderate spinal contusion. (Ellingson BM, Kurpad SN, Schmit BD) J Magn Reson Imaging 2008 Nov;28(5):1068-79 PMID: 18972347 10/31/2008
  • Diffusion tensor MR imaging in chronic spinal cord injury. (Ellingson BM, Ulmer JL, Kurpad SN, Schmit BD) AJNR Am J Neuroradiol 2008 Nov;29(10):1976-82 PMID: 18719029 08/23/2008
  • In vitro and in vivo characterization of neurally modified mesenchymal stem cells induced by epigenetic modifiers and neural stem cell environment. (Alexanian AR, Maiman DJ, Kurpad SN, Gennarelli TA) Stem Cells Dev 2008 Dec;17(6):1123-30 PMID: 18484898 05/20/2008
  • Diffusion tensor MR imaging of the neurologically intact human spinal cord. (Ellingson BM, Ulmer JL, Kurpad SN, Schmit BD) AJNR Am J Neuroradiol 2008 Aug;29(7):1279-84 PMID: 18417607 04/18/2008
  • In vivo diffusion tensor imaging of the rat spinal cord at 9.4T. (Ellingson BM, Kurpad SN, Li SJ, Schmit BD) J Magn Reson Imaging 2008 Mar;27(3):634-42 PMID: 18224673 01/29/2008
  • Pain with no gain: allodynia following neural stem cell transplantation in spinal cord injury. (Macias MY, Syring MB, Pizzi MA, Crowe MJ, Alexanian AR, Kurpad SN) Exp Neurol 2006 Oct;201(2):335-48 PMID: 16839548 07/15/2006
  • Minimally invasive, extracavitary approach for thoracic disc herniation: technical report and preliminary results. (Lidar Z, Lifshutz J, Bhattacharjee S, Kurpad SN, Maiman DJ) Spine J 2006 Mar-Apr;6(2):157-63 PMID: 16517387 03/07/2006
  • Efficient differentiation and integration of lineage-restricted neural precursors in the traumatically injured adult cat spinal cord. (Alexanian AR, Crowe MJ, Kurpad SN) J Neurosci Methods 2006 Jan 15;150(1):41-6 PMID: 16087243 08/10/2005
  • Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome. (Hofstetter CP, Holmström NA, Lilja JA, Schweinhardt P, Hao J, Spenger C, Wiesenfeld-Hallin Z, Kurpad SN, Frisén J, Olson L) Nat Neurosci 2005 Mar;8(3):346-53 PMID: 15711542 02/16/2005
  • Quiescent neural cells regain multipotent stem cell characteristics influenced by adult neural stem cells in co-culture. (Alexanian AR, Kurpad SN) Exp Neurol 2005 Jan;191(1):193-7 PMID: 15589526 12/14/2004
  • Bioresorbable fixation for congenital pediatric craniofacial surgery: a 2-year follow-up. (Kurpad SN, Goldstein JA, Cohen AR) Pediatr Neurosurg 2000 Dec;33(6):306-10 PMID: 11182641 02/22/2001
  • Posterior fossa craniotomy: an alternative to craniectomy. (Kurpad SN, Cohen AR) Pediatr Neurosurg 1999 Jul;31(1):54-7 PMID: 10545825 11/05/1999
  • Intraarterial O6-benzylguanine enables the specific therapy of nitrosourea-resistant intracranial human glioma xenografts in athymic rats with 1,3-bis(2-chloroethyl)-1-nitrosourea. (Kurpad SN, Dolan ME, McLendon RE, Archer GE, Moschel RC, Pegg AE, Bigner DD, Friedman HS) Cancer Chemother Pharmacol 1997;39(4):307-16 PMID: 9025771 01/01/1997
  • Tumor antigens in astrocytic gliomas. (Kurpad SN, Zhao XG, Wikstrand CJ, Batra SK, McLendon RE, Bigner DD) Glia 1995 Nov;15(3):244-56 PMID: 8586461 11/01/1995
  • Tumor-specific anti-epidermal growth factor receptor variant III monoclonal antibodies: use of the tyramine-cellobiose radioiodination method enhances cellular retention and uptake in tumor xenografts. (Reist CJ, Archer GE, Kurpad SN, Wikstrand CJ, Vaidyanathan G, Willingham MC, Moscatello DK, Wong AJ, Bigner DD, Zalutsky MR) Cancer Res 1995 Oct 01;55(19):4375-82 PMID: 7671250 10/01/1995
  • Intraarterial administration of melphalan for treatment of intracranial human glioma xenografts in athymic rats. (Kurpad SN, Friedman HS, Archer GE, McLendon RE, Petros WM, Fuchs HE, Guaspari A, Bigner DD) Cancer Res 1995 Sep 01;55(17):3803-9 PMID: 7641197 09/01/1995
  • Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas. (Wikstrand CJ, Hale LP, Batra SK, Hill ML, Humphrey PA, Kurpad SN, McLendon RE, Moscatello D, Pegram CN, Reist CJ) Cancer Res 1995 Jul 15;55(14):3140-8 PMID: 7606735 07/15/1995
  • Immunobiology of malignant astrocytomas. (Kurpad SN, Wikstrand CJ, Bigner DD) Semin Oncol 1994 Apr;21(2):149-61 PMID: 8153661 04/01/1994
  • Last update: 06/15/2017
    jenkins-FCD Prod-153 3ca6710ea990189ceb85f4312e7298b5922ce1a6