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Publications indexed to the term Receptors, G-Protein-Coupled

FacultyTitle
1The cardioprotective role of the G protein-coupled receptor FFAR4 in atherosclerosis is independent of macrophage foam cell regulation. (Stuttgen GM, Ring CJ, Guda VS, Valdivia Esparza GK, Sahoo D) J Biol Chem 2025 May;301(5):108463    
1Structure and dynamics determine G protein coupling specificity at a class A GPCR. (Casiraghi M, Wang H, Brennan PC, Habrian C, Hübner H, Schmidt MF, Maul L, Pani B, Bahriz SMFM, Xu B, Staffen N, Assafa TE, Chen B, White E, Sunahara RK, Inoue A, Xiang YK, Lefkowitz RJ, Isacoff EY, Nucci N, Gmeiner P, Lerch MT, Kobilka BK) Sci Adv 2025 Mar 21;11(12):eadq3971       1 Citation
1FFAR4 Deficiency Increases Necrotic Cores in Advanced Lesions of ApoE-/- Mice-Brief Report. (Stuttgen GM, Bobek JM, Penoske R, Wadding-Lee C, Lam M, Hader SN, Owens AP 3rd, Sahoo D) Arterioscler Thromb Vasc Biol 2025 May;45(5):675-682       1 Citation
1Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation. (Liu AW, Zhang YR, Chen CS, Edwards TN, Ozyaman S, Ramcke T, McKendrick LM, Weiss ES, Gillis JE, Laughlin CR, Randhawa SK, Phelps CM, Kurihara K, Kang HM, Nguyen SN, Kim J, Sheahan TD, Ross SE, Meisel M, Sumpter TL, Kaplan DH) Science 2025 Jan 31;387(6733):eadn9390       6 Citations
1Biased signaling in GPCRs: Structural insights and implications for drug development. (Ma Y, Patterson B, Zhu L) Pharmacol Ther 2025 Feb;266:108786       1 Citation
1Molecular basis for chemokine recognition and activation of XCR1. (Zhang X, Schlimgen RR, Singh S, Tomani MP, Volkman BF, Zhang C) Proc Natl Acad Sci U S A 2024 Nov 26;121(48):e2405732121       3 Citations
1Understanding the genetic complexity of puberty timing across the allele frequency spectrum. (Kentistou KA, Kaisinger LR, Stankovic S, Vaudel M, Mendes de Oliveira E, Messina A, Walters RG, Liu X, Busch AS, Helgason H, Thompson DJ, Santoni F, Petricek KM, Zouaghi Y, Huang-Doran I, Gudbjartsson DF, Bratland E, Lin K, Gardner EJ, Zhao Y, Jia RY, Terao C, Riggan MJ, Bolla MK, Yazdanpanah M, Yazdanpanah N, Bradfield JP, Broer L, Campbell A, Chasman DI, Cousminer DL, Franceschini N, Franke LH, Girotto G, He C, Järvelin MR, Joshi PK, Kamatani Y, Karlsson R, Luan J, Lunetta KL, Mägi R, Mangino M, Medland SE, Meisinger C, Noordam R, Nutile T, Concas MP, Polašek O, Porcu E, Ring SM, Sala C, Smith AV, Tanaka T, van der Most PJ, Vitart V, Wang CA, Willemsen G, Zygmunt M, Ahearn TU, Andrulis IL, Anton-Culver H, Antoniou AC, Auer PL, Barnes CLK, Beckmann MW, Berrington de Gonzalez A, Bogdanova NV, Bojesen SE, Brenner H, Buring JE, Canzian F, Chang-Claude J, Couch FJ, Cox A, Crisponi L, Czene K, Daly MB, Demerath EW, Dennis J, Devilee P, De Vivo I, Dörk T, Dunning AM, Dwek M, Eriksson JG, Fasching PA, Fernandez-Rhodes L, Ferreli L, Fletcher O, Gago-Dominguez M, García-Closas M, García-Sáenz JA, González-Neira A, Grallert H, Guénel P, Haiman CA, Hall P, Hamann U, Hakonarson H, Hart RJ, Hickey M, Hooning MJ, Hoppe R, Hopper JL, Hottenga JJ, Hu FB, Huebner H, Hunter DJ, ABCTB Investigators, Jernström H, John EM, Karasik D, Khusnutdinova EK, Kristensen VN, Lacey JV, Lambrechts D, Launer LJ, Lind PA, Lindblom A, Magnusson PKE, Mannermaa A, McCarthy MI, Meitinger T, Menni C, Michailidou K, Millwood IY, Milne RL, Montgomery GW, Nevanlinna H, Nolte IM, Nyholt DR, Obi N, O'Brien KM, Offit K, Oldehinkel AJ, Ostrowski SR, Palotie A, Pedersen OB, Peters A, Pianigiani G, Plaseska-Karanfilska D, Pouta A, Pozarickij A, Radice P, Rennert G, Rosendaal FR, Ruggiero D, Saloustros E, Sandler DP, Schipf S, Schmidt CO, Schmidt MK, Small K, Spedicati B, Stampfer M, Stone J, Tamimi RM, Teras LR, Tikkanen E, Turman C, Vachon CM, Wang Q, Winqvist R, Wolk A, Zemel BS, Zheng W, van Dijk KW, Alizadeh BZ, Bandinelli S, Boerwinkle E, Boomsma DI, Ciullo M, Chenevix-Trench G, Cucca F, Esko T, Gieger C, Grant SFA, Gudnason V, Hayward C, Kolčić I, Kraft P, Lawlor DA, Martin NG, Nøhr EA, Pedersen NL, Pennell CE, Ridker PM, Robino A, Snieder H, Sovio U, Spector TD, Stöckl D, Sudlow C, Timpson NJ, Toniolo D, Uitterlinden A, Ulivi S, Völzke H, Wareham NJ, Widen E, Wilson JF, Lifelines Cohort Study, Danish Blood Donor Study, Ovarian Cancer Association Consortium, Breast Cancer Association Consortium, Biobank Japan Project, China Kadoorie Biobank Collaborative Group, Pharoah PDP, Li L, Easton DF, Njølstad PR, Sulem P, Murabito JM, Murray A, Manousaki D, Juul A, Erikstrup C, Stefansson K, Horikoshi M, Chen Z, Farooqi IS, Pitteloud N, Johansson S, Day FR, Perry JRB, Ong KK) Nat Genet 2024 Jul;56(7):1397-1411       16 Citations
1G protein-coupled estrogen receptor (GPER) in the dorsal hippocampus regulates memory consolidation in gonadectomized male mice, likely via different signaling mechanisms than in female mice. (Machado GDB, Schnitzler AL, Fleischer AW, Beamish SB, Frick KM) Horm Behav 2024 May;161:105516       1 Citation
1Functional profiling of the G protein-coupled receptor C3aR1 reveals ligand-mediated biased agonism. (Rodriguez P, Laskowski LJ, Pallais JP, Bock HA, Cavalco NG, Anderson EI, Calkins MM, Razzoli M, Sham YY, McCorvy JD, Bartolomucci A) J Biol Chem 2024 Jan;300(1):105549       6 Citations
6The changing spectrum of infection with BCMA and GPRC5D targeting bispecific antibody (bsAb) therapy in patients with relapsed refractory multiple myeloma. (Hammons L, Szabo A, Janardan A, Bhatlapenumarthi V, Annyapu E, Dhakal B, Al Hadidi S, Radhakrishnan SV, Narra R, Bhutani D, Thanendrarajan S, Janz S, Zangari M, Lentzsch S, Van Rhee F, Crescencio JCR, D'Souza A, Chakraborty R, Mohan M, Schinke C) Haematologica 2024 Mar 01;109(3):906-914       26 Citations
1Molecular insights into GPCR mechanisms for drugs of abuse. (Sanchez-Reyes OB, Zilberg G, McCorvy JD, Wacker D) J Biol Chem 2023 Sep;299(9):105176       3 Citations
1Bias-force guided simulations combined with experimental validations towards GPR17 modulators identification. (Kari S, Murugesan A, Thiyagarajan R, Kidambi S, Razzokov J, Selvaraj C, Kandhavelu M, Marimuthu P) Biomed Pharmacother 2023 Apr;160:114320       9 Citations
217β-Estradiol promotes sex-specific dysfunction in isolated human arterioles. (SenthilKumar G, Katunaric B, Bordas-Murphy H, Young M, Doren EL, Schulz ME, Widlansky ME, Freed JK) Am J Physiol Heart Circ Physiol 2023 Mar 01;324(3):H330-H337       15 Citations
1Structures of β1-adrenergic receptor in complex with Gs and ligands of different efficacies. (Su M, Paknejad N, Zhu L, Wang J, Do HN, Miao Y, Liu W, Hite RK, Huang XY) Nat Commun 2022 Jul 14;13(1):4095       18 Citations
1Structure, function and pharmacology of human itch GPCRs. (Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL) Nature 2021 Dec;600(7887):170-175       142 Citations
1FFAR4: A New Player in Cardiometabolic Disease? (Stuttgen GM, Sahoo D) Endocrinology 2021 Aug 01;162(8)       23 Citations
1Estradiol Regulation of the Prelimbic Cortex and the Reinstatement of Cocaine Seeking in Female Rats. (Doncheck EM, Anderson EM, Konrath CD, Liddiard GT, DeBaker MC, Urbanik LA, Hearing MC, Mantsch JR) J Neurosci 2021 Jun 16;41(24):5303-5314       17 Citations
1Evidence that specific interactions play a role in the cholesterol sensitivity of G protein-coupled receptors. (Geiger J, Sexton R, Al-Sahouri Z, Lee MY, Chun E, Harikumar KG, Miller LJ, Beckstein O, Liu W) Biochim Biophys Acta Biomembr 2021 Sep 01;1863(9):183557       12 Citations
2Specific binding-induced modulation of the XCL1 metamorphic equilibrium. (Dishman AF, Peterson FC, Volkman BF) Biopolymers 2021 Oct;112(10):e23402    
2Serial Crystallography for Structure-Based Drug Discovery. (Zhu L, Chen X, Abola EE, Jing L, Liu W) Trends Pharmacol Sci 2020 Nov;41(11):830-839       15 Citations
1TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome. (Olsen RHJ, DiBerto JF, English JG, Glaudin AM, Krumm BE, Slocum ST, Che T, Gavin AC, McCorvy JD, Roth BL, Strachan RT) Nat Chem Biol 2020 Aug;16(8):841-849       354 Citations
1Interaction between Mas1 and AT1RA contributes to enhancement of skeletal muscle angiogenesis by angiotensin-(1-7) in Dahl salt-sensitive rats. (Exner EC, Geurts AM, Hoffmann BR, Casati M, Stodola T, Dsouza NR, Zimmermann M, Lombard JH, Greene AS) PLoS One 2020;15(4):e0232067       9 Citations
2Combined burden and functional impact tests for cancer driver discovery using DriverPower. (Shuai S, PCAWG Drivers and Functional Interpretation Working Group, Gallinger S, Stein LD, PCAWG Consortium) Nat Commun 2020 Feb 05;11(1):734       30 Citations
1Dorsal Hippocampal Actin Polymerization Is Necessary for Activation of G-Protein-Coupled Estrogen Receptor (GPER) to Increase CA1 Dendritic Spine Density and Enhance Memory Consolidation. (Kim J, Schalk JC, Koss WA, Gremminger RL, Taxier LR, Gross KS, Frick KM) J Neurosci 2019 Nov 27;39(48):9598-9610       40 Citations
1Structure-function guided modeling of chemokine-GPCR specificity for the chemokine XCL1 and its receptor XCR1. (Fox JC, Thomas MA, Dishman AF, Larsen O, Nakayama T, Yoshie O, Rosenkilde MM, Volkman BF) Sci Signal 2019 Sep 03;12(597)       17 Citations
1Designing Functionally Selective Noncatechol Dopamine D1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity. (Martini ML, Ray C, Yu X, Liu J, Pogorelov VM, Wetsel WC, Huang XP, McCorvy JD, Caron MG, Jin J) ACS Chem Neurosci 2019 Sep 18;10(9):4160-4182       24 Citations
1A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma. (Lytle NK, Ferguson LP, Rajbhandari N, Gilroy K, Fox RG, Deshpande A, Schürch CM, Hamilton M, Robertson N, Lin W, Noel P, Wartenberg M, Zlobec I, Eichmann M, Galván JA, Karamitopoulou E, Gilderman T, Esparza LA, Shima Y, Spahn P, French R, Lewis NE, Fisch KM, Sasik R, Rosenthal SB, Kritzik M, Von Hoff D, Han H, Ideker T, Deshpande AJ, Lowy AM, Adams PD, Reya T) Cell 2019 Apr 18;177(3):572-586.e22       115 Citations
1Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations. (Wingler LM, Elgeti M, Hilger D, Latorraca NR, Lerch MT, Staus DP, Dror RO, Kobilka BK, Hubbell WL, Lefkowitz RJ) Cell 2019 Jan 24;176(3):468-478.e11       203 Citations
1Solution NMR spectroscopy of GPCRs: Residue-specific labeling strategies with a focus on 13C-methyl methionine labeling of the atypical chemokine receptor ACKR3. (Kleist AB, Peterson F, Tyler RC, Gustavsson M, Handel TM, Volkman BF) Methods Cell Biol 2019;149:259-288       9 Citations
1Structure-activity profiling of alkaloid natural product pharmacophores against a Schistosoma serotonin receptor. (Marchant JS, Harding WW, Chan JD) Int J Parasitol Drugs Drug Resist 2018 Dec;8(3):550-558       13 Citations
1Biased Ligands of G Protein-Coupled Receptors (GPCRs): Structure-Functional Selectivity Relationships (SFSRs) and Therapeutic Potential. (Tan L, Yan W, McCorvy JD, Cheng J) J Med Chem 2018 Nov 21;61(22):9841-9878       100 Citations
2GPR40 is a low-affinity epoxyeicosatrienoic acid receptor in vascular cells. (Park SK, Herrnreiter A, Pfister SL, Gauthier KM, Falck BA, Falck JR, Campbell WB) J Biol Chem 2018 Jul 06;293(27):10675-10691       54 Citations
1Regulators of G protein signaling in cardiovascular function during pregnancy. (Perschbacher KJ, Deng G, Fisher RA, Gibson-Corley KN, Santillan MK, Grobe JL) Physiol Genomics 2018 Aug 01;50(8):590-604       31 Citations
2Loss of FFAR2 promotes colon cancer by epigenetic dysregulation of inflammation suppressors. (Pan P, Oshima K, Huang YW, Agle KA, Drobyski WR, Chen X, Zhang J, Yearsley MM, Yu J, Wang LS) Int J Cancer 2018 Aug 15;143(4):886-896       73 Citations
1Unique pharmacological properties of serotoninergic G-protein coupled receptors from cestodes. (Camicia F, Celentano AM, Johns ME, Chan JD, Maldonado L, Vaca H, Di Siervi N, Kamentezky L, Gamo AM, Ortega-Gutierrez S, Martin-Fontecha M, Davio C, Marchant JS, Rosenzvit MC) PLoS Negl Trop Dis 2018 Feb;12(2):e0006267       24 Citations
1PAR1 agonists stimulate APC-like endothelial cytoprotection and confer resistance to thromboinflammatory injury. (De Ceunynck K, Peters CG, Jain A, Higgins SJ, Aisiku O, Fitch-Tewfik JL, Chaudhry SA, Dockendorff C, Parikh SM, Ingber DE, Flaumenhaft R) Proc Natl Acad Sci U S A 2018 Jan 30;115(5):E982-E991       59 Citations
1An Antimicrobial Peptide and Its Neuronal Receptor Regulate Dendrite Degeneration in Aging and Infection. (E L, Zhou T, Koh S, Chuang M, Sharma R, Pujol N, Chisholm AD, Eroglu C, Matsunami H, Yan D) Neuron 2018 Jan 03;97(1):125-138.e5       74 Citations
1Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs. (McCorvy JD, Butler KV, Kelly B, Rechsteiner K, Karpiak J, Betz RM, Kormos BL, Shoichet BK, Dror RO, Jin J, Roth BL) Nat Chem Biol 2018 Feb;14(2):126-134       141 Citations
2Genome-Wide Association Study to Find Modifiers for Tetralogy of Fallot in the 22q11.2 Deletion Syndrome Identifies Variants in the GPR98 Locus on 5q14.3. (Guo T, Repetto GM, McDonald McGinn DM, Chung JH, Nomaru H, Campbell CL, Blonska A, Bassett AS, Chow EWC, Mlynarski EE, Swillen A, Vermeesch J, Devriendt K, Gothelf D, Carmel M, Michaelovsky E, Schneider M, Eliez S, Antonarakis SE, Coleman K, Tomita-Mitchell A, Mitchell ME, Digilio MC, Dallapiccola B, Marino B, Philip N, Busa T, Kushan-Wells L, Bearden CE, Piotrowicz M, Hawuła W, Roberts AE, Tassone F, Simon TJ, van Duin EDA, van Amelsvoort TA, Kates WR, Zackai E, Johnston HR, Cutler DJ, Agopian AJ, Goldmuntz E, Mitchell LE, Wang T, Emanuel BS, Morrow BE, International 22q11.2 Consortium/Brain and Behavior Consortium*) Circ Cardiovasc Genet 2017 Oct;10(5):e001690       20 Citations
1Development and characterization of cholangioids from normal and diseased human cholangiocytes as an in vitro model to study primary sclerosing cholangitis. (Loarca L, De Assuncao TM, Jalan-Sakrikar N, Bronk S, Krishnan A, Huang B, Morton L, Trussoni C, Bonilla LM, Krueger E, O'Hara S, Splinter P, Shi G, Pisarello MJL, Gores GJ, Huebert RC, LaRusso NF) Lab Invest 2017 Nov;97(11):1385-1396       38 Citations
1Bioactivity of the putative apelin proprotein expands the repertoire of apelin receptor ligands. (Shin K, Chapman NA, Sarker M, Kenward C, Huang SK, Weatherbee-Martin N, Pandey A, Dupré DJ, Rainey JK) Biochim Biophys Acta Gen Subj 2017 Aug;1861(8):1901-1912       30 Citations
1In silico design of novel probes for the atypical opioid receptor MRGPRX2. (Lansu K, Karpiak J, Liu J, Huang XP, McCorvy JD, Kroeze WK, Che T, Nagase H, Carroll FI, Jin J, Shoichet BK, Roth BL) Nat Chem Biol 2017 May;13(5):529-536       231 Citations
2Loss of free fatty acid receptor 2 enhances colonic adenoma development and reduces the chemopreventive effects of black raspberries in ApcMin/+ mice. (Pan P, W Skaer C, Wang HT, Oshima K, Huang YW, Yu J, Zhang J, M Yearsley M, A Agle K, R Drobyski W, Chen X, Wang LS) Carcinogenesis 2017 Jan;38(1):86-93       40 Citations
2Successful Strategies to Determine High-Resolution Structures of GPCRs. (Xiang J, Chun E, Liu C, Jing L, Al-Sahouri Z, Zhu L, Liu W) Trends Pharmacol Sci 2016 Dec;37(12):1055-1069       57 Citations
2Exploiting agonist biased signaling of chemokines to target cancer. (Roy I, Getschman AE, Volkman BF, Dwinell MB) Mol Carcinog 2017 Mar;56(3):804-813       16 Citations
2Serial Femtosecond Crystallography of Membrane Proteins. (Zhu L, Weierstall U, Cherezov V, Liu W) Adv Exp Med Biol 2016;922:151-160       10 Citations
1Kinetic profiling an abundantly expressed planarian serotonergic GPCR identifies bromocriptine as a perdurant antagonist. (Chan JD, Grab T, Marchant JS) Int J Parasitol Drugs Drug Resist 2016 Dec;6(3):356-363       16 Citations
1Pharmacological profiling an abundantly expressed schistosome serotonergic GPCR identifies nuciferine as a potent antagonist. (Chan JD, Acharya S, Day TA, Marchant JS) Int J Parasitol Drugs Drug Resist 2016 Dec;6(3):364-370       22 Citations
2A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors. (Chan JD, McCorvy JD, Acharya S, Johns ME, Day TA, Roth BL, Marchant JS) PLoS Pathog 2016 May;12(5):e1005651       30 Citations
4Vascular Actions of Angiotensin 1-7 in the Human Microcirculation: Novel Role for Telomerase. (Durand MJ, Zinkevich NS, Riedel M, Gutterman DD, Nasci VL, Salato VK, Hijjawi JB, Reuben CF, North PE, Beyer AM) Arterioscler Thromb Vasc Biol 2016 Jun;36(6):1254-62       55 Citations
1TRPC6 channel translocation into phagosomal membrane augments phagosomal function. (Riazanski V, Gabdoulkhakova AG, Boynton LS, Eguchi RR, Deriy LV, Hogarth DK, Loaëc N, Oumata N, Galons H, Brown ME, Shevchenko P, Gallan AJ, Yoo SG, Naren AP, Villereal ML, Beacham DW, Bindokas VP, Birnbaumer L, Meijer L, Nelson DJ) Proc Natl Acad Sci U S A 2015 Nov 24;112(47):E6486-95       61 Citations
1Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic α-cells. (Elrick MM, Samson WK, Corbett JA, Salvatori AS, Stein LM, Kolar GR, Naatz A, Yosten GL) Am J Physiol Regul Integr Comp Physiol 2016 Jan 15;310(2):R143-55       38 Citations
1MicroRNA-31 negatively regulates peripherally derived regulatory T-cell generation by repressing retinoic acid-inducible protein 3. (Zhang L, Ke F, Liu Z, Bai J, Liu J, Yan S, Xu Z, Lou F, Wang H, Zhu H, Sun Y, Cai W, Gao Y, Li Q, Yu XZ, Qian Y, Hua Z, Deng J, Li QJ, Wang H) Nat Commun 2015 Jul 13;6:7639       82 Citations
1SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins. (Dror RO, Mildorf TJ, Hilger D, Manglik A, Borhani DW, Arlow DH, Philippsen A, Villanueva N, Yang Z, Lerch MT, Hubbell WL, Kobilka BK, Sunahara RK, Shaw DE) Science 2015 Jun 19;348(6241):1361-5       234 Citations
1Structural Determinants for the Selective Anti-HIV-1 Activity of the All-β Alternative Conformer of XCL1. (Guzzo C, Fox JC, Miao H, Volkman BF, Lusso P) J Virol 2015 Sep;89(17):9061-7       13 Citations
1Regulation of GPCR Trafficking by Ubiquitin. (Kennedy JE, Marchese A) Prog Mol Biol Transl Sci 2015;132:15-38       47 Citations
1PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome. (Kroeze WK, Sassano MF, Huang XP, Lansu K, McCorvy JD, Giguère PM, Sciaky N, Roth BL) Nat Struct Mol Biol 2015 May;22(5):362-9       539 Citations
1Heteromerization of chemokine (C-X-C motif) receptor 4 with α1A/B-adrenergic receptors controls α1-adrenergic receptor function. (Tripathi A, Vana PG, Chavan TS, Brueggemann LI, Byron KL, Tarasova NI, Volkman BF, Gaponenko V, Majetschak M) Proc Natl Acad Sci U S A 2015 Mar 31;112(13):E1659-68       57 Citations
1GPCR crystallization using lipidic cubic phase technique. (Yin X, Xu H, Hanson M, Liu W) Curr Pharm Biotechnol 2014;15(10):971-9       8 Citations
1Smooth muscle-protein translocation and tissue function. (Eddinger TJ) Anat Rec (Hoboken) 2014 Sep;297(9):1734-46       5 Citations
1Ablation of the GNB3 gene in mice does not affect body weight, metabolism or blood pressure, but causes bradycardia. (Ye Y, Sun Z, Guo A, Song LS, Grobe JL, Chen S) Cell Signal 2014 Nov;26(11):2514-20       14 Citations
1Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography. (Weierstall U, James D, Wang C, White TA, Wang D, Liu W, Spence JC, Bruce Doak R, Nelson G, Fromme P, Fromme R, Grotjohann I, Kupitz C, Zatsepin NA, Liu H, Basu S, Wacker D, Han GW, Katritch V, Boutet S, Messerschmidt M, Williams GJ, Koglin JE, Marvin Seibert M, Klinker M, Gati C, Shoeman RL, Barty A, Chapman HN, Kirian RA, Beyerlein KR, Stevens RC, Li D, Shah ST, Howe N, Caffrey M, Cherezov V) Nat Commun 2014;5:3309       480 Citations
1Serial femtosecond crystallography of G protein-coupled receptors. (Liu W, Wacker D, Gati C, Han GW, James D, Wang D, Nelson G, Weierstall U, Katritch V, Barty A, Zatsepin NA, Li D, Messerschmidt M, Boutet S, Williams GJ, Koglin JE, Seibert MM, Wang C, Shah ST, Basu S, Fromme R, Kupitz C, Rendek KN, Grotjohann I, Fromme P, Kirian RA, Beyerlein KR, White TA, Chapman HN, Caffrey M, Spence JC, Stevens RC, Cherezov V) Science 2013 Dec 20;342(6165):1521-4       402 Citations
1G-protein coupled receptor 56 promotes myoblast fusion through serum response factor- and nuclear factor of activated T-cell-mediated signalling but is not essential for muscle development in vivo. (Wu MP, Doyle JR, Barry B, Beauvais A, Rozkalne A, Piao X, Lawlor MW, Kopin AS, Walsh CA, Gussoni E) FEBS J 2013 Dec;280(23):6097-113       40 Citations
1A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis. (Masiero M, Simões FC, Han HD, Snell C, Peterkin T, Bridges E, Mangala LS, Wu SY, Pradeep S, Li D, Han C, Dalton H, Lopez-Berestein G, Tuynman JB, Mortensen N, Li JL, Patient R, Sood AK, Banham AH, Harris AL, Buffa FM) Cancer Cell 2013 Aug 12;24(2):229-41       252 Citations
1Structure of the human smoothened receptor bound to an antitumour agent. (Wang C, Wu H, Katritch V, Han GW, Huang XP, Liu W, Siu FY, Roth BL, Cherezov V, Stevens RC) Nature 2013 May 16;497(7449):338-43       419 Citations
1N-Arachidonoyl glycine suppresses Na⁺/Ca²⁺ exchanger-mediated Ca²⁺ entry into endothelial cells and activates BK(Ca) channels independently of GPCRs. (Bondarenko AI, Drachuk K, Panasiuk O, Sagach V, Deak AT, Malli R, Graier WF) Br J Pharmacol 2013 Jun;169(4):933-48       23 Citations
2Adenosine A1 receptors heterodimerize with β1- and β2-adrenergic receptors creating novel receptor complexes with altered G protein coupling and signaling. (Chandrasekera PC, Wan TC, Gizewski ET, Auchampach JA, Lasley RD) Cell Signal 2013 Apr;25(4):736-42       38 Citations
2Endothelial 12(S)-HETE vasorelaxation is mediated by thromboxane receptor inhibition in mouse mesenteric arteries. (Siangjong L, Gauthier KM, Pfister SL, Smyth EM, Campbell WB) Am J Physiol Heart Circ Physiol 2013 Feb 01;304(3):H382-92       22 Citations
1Ubiquitin-dependent regulation of G protein-coupled receptor trafficking and signaling. (Marchese A, Trejo J) Cell Signal 2013 Mar;25(3):707-16       72 Citations
1Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis. (Neal MD, Sodhi CP, Jia H, Dyer M, Egan CE, Yazji I, Good M, Afrazi A, Marino R, Slagle D, Ma C, Branca MF, Prindle T Jr, Grant Z, Ozolek J, Hackam DJ) J Biol Chem 2012 Oct 26;287(44):37296-308       182 Citations
1Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptors. (Chun E, Thompson AA, Liu W, Roth CB, Griffith MT, Katritch V, Kunken J, Xu F, Cherezov V, Hanson MA, Stevens RC) Structure 2012 Jun 06;20(6):967-76       369 Citations
1Structural determinants of ubiquitin-CXC chemokine receptor 4 interaction. (Saini V, Marchese A, Tang WJ, Majetschak M) J Biol Chem 2011 Dec 23;286(51):44145-44152       39 Citations
1Ubiquitination of GPCRs. (Caballero A, Marchese A) Methods Mol Biol 2011;746:251-9       5 Citations
1Few residues within an extensive binding interface drive receptor interaction and determine the specificity of arrestin proteins. (Vishnivetskiy SA, Gimenez LE, Francis DJ, Hanson SM, Hubbell WL, Klug CS, Gurevich VV) J Biol Chem 2011 Jul 08;286(27):24288-99       106 Citations
1Small ubiquitin-like modifier modification of arrestin-3 regulates receptor trafficking. (Wyatt D, Malik R, Vesecky AC, Marchese A) J Biol Chem 2011 Feb 04;286(5):3884-93       43 Citations
1Maternal riboflavin deficiency, resulting in transient neonatal-onset glutaric aciduria Type 2, is caused by a microdeletion in the riboflavin transporter gene GPR172B. (Ho G, Yonezawa A, Masuda S, Inui K, Sim KG, Carpenter K, Olsen RK, Mitchell JJ, Rhead WJ, Peters G, Christodoulou J) Hum Mutat 2011 Jan;32(1):E1976-84       101 Citations
1Characterization of soy-based changes in Wnt-frizzled signaling in prostate cancer. (Liss MA, Schlicht M, Kahler A, Fitzgerald R, Thomassi T, Degueme A, Hessner M, Datta MW) Cancer Genomics Proteomics 2010;7(5):245-52    
1Novel mechanisms in the regulation of G protein-coupled receptor trafficking to the plasma membrane. (Tholanikunnel BG, Joseph K, Kandasamy K, Baldys A, Raymond JR, Luttrell LM, McDermott PJ, Fernandes DJ) J Biol Chem 2010 Oct 29;285(44):33816-25       13 Citations
1Bradykinin decreases podocyte permeability through ADAM17-dependent epidermal growth factor receptor activation and zonula occludens-1 rearrangement. (Dey M, Baldys A, Sumter DB, Göoz P, Luttrell LM, Raymond JR, Göoz M) J Pharmacol Exp Ther 2010 Sep 01;334(3):775-83       33 Citations
1Histidine-rich glycoprotein modulates the anti-angiogenic effects of vasculostatin. (Klenotic PA, Huang P, Palomo J, Kaur B, Van Meir EG, Vogelbaum MA, Febbraio M, Gladson CL, Silverstein RL) Am J Pathol 2010 Apr;176(4):2039-50       46 Citations
1Relaxin-3 and receptors in the human and rhesus brain and reproductive tissues. (Silvertown JD, Neschadim A, Liu HN, Shannon P, Walia JS, Kao JC, Robertson J, Summerlee AJ, Medin JA) Regul Pept 2010 Jan 08;159(1-3):44-53       24 Citations
1Ubiquitination regulates proteolytic processing of G protein-coupled receptors after their sorting to lysosomes. (Hislop JN, Henry AG, Marchese A, von Zastrow M) J Biol Chem 2009 Jul 17;284(29):19361-70       76 Citations
1Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism. (Kaur B, Cork SM, Sandberg EM, Devi NS, Zhang Z, Klenotic PA, Febbraio M, Shim H, Mao H, Tucker-Burden C, Silverstein RL, Brat DJ, Olson JJ, Van Meir EG) Cancer Res 2009 Feb 01;69(3):1212-20       99 Citations
1The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction. (Bhandari D, Robia SL, Marchese A) Mol Biol Cell 2009 Mar;20(5):1324-39       77 Citations
1G protein-coupled receptor sorting to endosomes and lysosomes. (Marchese A, Paing MM, Temple BR, Trejo J) Annu Rev Pharmacol Toxicol 2008;48:601-29       380 Citations
1Cyclic AMP-independent CGRP8-37-sensitive receptors mediate adrenomedullin-induced decrease of CaCl2-contraction in pregnant rat mesenteric artery. (Ross GR, Yallampalli U, Yallampalli C) J Vasc Res 2008;45(1):33-44       4 Citations
1Epistatic interaction between haplotypes of the ghrelin ligand and receptor genes influence susceptibility to myocardial infarction and coronary artery disease. (Baessler A, Fischer M, Mayer B, Koehler M, Wiedmann S, Stark K, Doering A, Erdmann J, Riegger G, Schunkert H, Kwitek AE, Hengstenberg C) Hum Mol Genet 2007 Apr 15;16(8):887-99       37 Citations
2An engineered second disulfide bond restricts lymphotactin/XCL1 to a chemokine-like conformation with XCR1 agonist activity. (Tuinstra RL, Peterson FC, Elgin ES, Pelzek AJ, Volkman BF) Biochemistry 2007 Mar 13;46(10):2564-73       52 Citations
1Adrenomedullin-2, a novel calcitonin/calcitonin-gene-related peptide family peptide, relaxes rat mesenteric artery: influence of pregnancy. (Chauhan M, Ross GR, Yallampalli U, Yallampalli C) Endocrinology 2007 Apr;148(4):1727-35       38 Citations
1Differential helical orientations among related G protein-coupled receptors provide a novel mechanism for selectivity. Studies with salvinorin A and the kappa-opioid receptor. (Vortherms TA, Mosier PD, Westkaemper RB, Roth BL) J Biol Chem 2007 Feb 02;282(5):3146-56       34 Citations
1Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7). (Grobe JL, Mecca AP, Lingis M, Shenoy V, Bolton TA, Machado JM, Speth RC, Raizada MK, Katovich MJ) Am J Physiol Heart Circ Physiol 2007 Feb;292(2):H736-42       315 Citations
1Association of the Ghrelin receptor gene region with left ventricular hypertrophy in the general population: results of the MONICA/KORA Augsburg Echocardiographic Substudy. (Baessler A, Kwitek AE, Fischer M, Koehler M, Reinhard W, Erdmann J, Riegger G, Doering A, Schunkert H, Hengstenberg C) Hypertension 2006 May;47(5):920-7       26 Citations
1Genetic linkage and association of the growth hormone secretagogue receptor (ghrelin receptor) gene in human obesity. (Baessler A, Hasinoff MJ, Fischer M, Reinhard W, Sonnenberg GE, Olivier M, Erdmann J, Schunkert H, Doering A, Jacob HJ, Comuzzie AG, Kissebah AH, Kwitek AE) Diabetes 2005 Jan;54(1):259-67       85 Citations
1Ubiquitination of G-protein-coupled receptors. (Marchese A, Benovic JL) Methods Mol Biol 2004;259:299-305       15 Citations
1Professor Robert J. Lefkowitz, M.D., scientist and mentor extraordinaire. (Inglese J, Raymond JR) Assay Drug Dev Technol 2003 Apr;1(2):227-31    
1Expression of G-protein alpha subunit genes in the vestibular periphery of Rattus norvegicus and their chromosomal mapping. (Cioffi JA, Erbe CB, Raphael R, Kwitek AE, Tiwari UK, Jacob HJ, Popper P, Wackym PA) Acta Otolaryngol 2003 Dec;123(9):1027-34       7 Citations
1Dual regulation of cryptochrome 1 mRNA expression in chicken retina by light and circadian oscillators. (Haque R, Chaurasia SS, Wessel JH 3rd, Iuvone PM) Neuroreport 2002 Dec 03;13(17):2247-51       93 Citations
1Platelet-activating factor priming of inflammatory cell activity requires cellular adherence. (Cuschieri J, Gourlay D, Bulger E, Garcia I, Jelacic S, Maier RV) Surgery 2002 Aug;132(2):157-66       7 Citations
1Molecular cloning, tissue-specific expression, and chromosomal localization of a novel nerve growth factor-regulated G-protein- coupled receptor, nrg-1. (Glickman M, Malek RL, Kwitek-Black AE, Jacob HJ, Lee NH) Mol Cell Neurosci 1999 Aug;14(2):141-52       67 Citations
1Human intestinal epithelial cells express receptors for platelet-activating factor. (Merendino N, Dwinell MB, Varki N, Eckmann L, Kagnoff MF) Am J Physiol 1999 Oct;277(4):G810-8       23 Citations
1The heterotrimeric G protein G alpha i2 mediates lysophosphatidic acid-stimulated induction of the c-fos gene in mouse fibroblasts. (Chuprun JK, Raymond JR, Blackshear PJ) J Biol Chem 1997 Jan 10;272(2):773-81       33 Citations
1G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism. (van Biesen T, Hawes BE, Raymond JR, Luttrell LM, Koch WJ, Lefkowitz RJ) J Biol Chem 1996 Jan 19;271(3):1266-9       190 Citations
1Tulopafant, a PAF receptor antagonist, increases capillary patency and prolongs survival in discordant cardiac xenotransplants. (O'Hair DP, Roza AM, Komorowski R, Moore G, McManus RP, Johnson CP, Adams MB, Pieper GM) J Lipid Mediat 1993 May;7(1):79-84       11 Citations