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1 | Structure and dynamics determine G protein coupling specificity at a class A GPCR. (Casiraghi M, Wang H, Brennan PC, Habrian C, Hübner H, Schmidt MF, Maul L, Pani B, Bahriz SMFM, Xu B, Staffen N, Assafa TE, Chen B, White E, Sunahara RK, Inoue A, Xiang YK, Lefkowitz RJ, Isacoff EY, Nucci N, Gmeiner P, Lerch MT, Kobilka BK) Sci Adv 2025 Mar 21;11(12):eadq3971 1 Citation |
1 | FFAR4 Deficiency Increases Necrotic Cores in Advanced Lesions of ApoE-/- Mice-Brief Report. (Stuttgen GM, Bobek JM, Penoske R, Wadding-Lee C, Lam M, Hader SN, Owens AP 3rd, Sahoo D) Arterioscler Thromb Vasc Biol 2025 May;45(5):675-682 1 Citation |
1 | Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation. (Liu AW, Zhang YR, Chen CS, Edwards TN, Ozyaman S, Ramcke T, McKendrick LM, Weiss ES, Gillis JE, Laughlin CR, Randhawa SK, Phelps CM, Kurihara K, Kang HM, Nguyen SN, Kim J, Sheahan TD, Ross SE, Meisel M, Sumpter TL, Kaplan DH) Science 2025 Jan 31;387(6733):eadn9390 6 Citations |
1 | Biased signaling in GPCRs: Structural insights and implications for drug development. (Ma Y, Patterson B, Zhu L) Pharmacol Ther 2025 Feb;266:108786 1 Citation |
1 | Molecular basis for chemokine recognition and activation of XCR1. (Zhang X, Schlimgen RR, Singh S, Tomani MP, Volkman BF, Zhang C) Proc Natl Acad Sci U S A 2024 Nov 26;121(48):e2405732121 3 Citations |
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1 | G protein-coupled estrogen receptor (GPER) in the dorsal hippocampus regulates memory consolidation in gonadectomized male mice, likely via different signaling mechanisms than in female mice. (Machado GDB, Schnitzler AL, Fleischer AW, Beamish SB, Frick KM) Horm Behav 2024 May;161:105516 1 Citation |
1 | Functional profiling of the G protein-coupled receptor C3aR1 reveals ligand-mediated biased agonism. (Rodriguez P, Laskowski LJ, Pallais JP, Bock HA, Cavalco NG, Anderson EI, Calkins MM, Razzoli M, Sham YY, McCorvy JD, Bartolomucci A) J Biol Chem 2024 Jan;300(1):105549 6 Citations |
6 | The changing spectrum of infection with BCMA and GPRC5D targeting bispecific antibody (bsAb) therapy in patients with relapsed refractory multiple myeloma. (Hammons L, Szabo A, Janardan A, Bhatlapenumarthi V, Annyapu E, Dhakal B, Al Hadidi S, Radhakrishnan SV, Narra R, Bhutani D, Thanendrarajan S, Janz S, Zangari M, Lentzsch S, Van Rhee F, Crescencio JCR, D'Souza A, Chakraborty R, Mohan M, Schinke C) Haematologica 2024 Mar 01;109(3):906-914 26 Citations |
1 | Molecular insights into GPCR mechanisms for drugs of abuse. (Sanchez-Reyes OB, Zilberg G, McCorvy JD, Wacker D) J Biol Chem 2023 Sep;299(9):105176 3 Citations |
1 | Bias-force guided simulations combined with experimental validations towards GPR17 modulators identification. (Kari S, Murugesan A, Thiyagarajan R, Kidambi S, Razzokov J, Selvaraj C, Kandhavelu M, Marimuthu P) Biomed Pharmacother 2023 Apr;160:114320 9 Citations |
2 | 17β-Estradiol promotes sex-specific dysfunction in isolated human arterioles. (SenthilKumar G, Katunaric B, Bordas-Murphy H, Young M, Doren EL, Schulz ME, Widlansky ME, Freed JK) Am J Physiol Heart Circ Physiol 2023 Mar 01;324(3):H330-H337 15 Citations |
1 | Structures of β1-adrenergic receptor in complex with Gs and ligands of different efficacies. (Su M, Paknejad N, Zhu L, Wang J, Do HN, Miao Y, Liu W, Hite RK, Huang XY) Nat Commun 2022 Jul 14;13(1):4095 18 Citations |
1 | Structure, function and pharmacology of human itch GPCRs. (Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL) Nature 2021 Dec;600(7887):170-175 142 Citations |
1 | FFAR4: A New Player in Cardiometabolic Disease? (Stuttgen GM, Sahoo D) Endocrinology 2021 Aug 01;162(8) 23 Citations |
1 | Estradiol Regulation of the Prelimbic Cortex and the Reinstatement of Cocaine Seeking in Female Rats. (Doncheck EM, Anderson EM, Konrath CD, Liddiard GT, DeBaker MC, Urbanik LA, Hearing MC, Mantsch JR) J Neurosci 2021 Jun 16;41(24):5303-5314 17 Citations |
1 | Evidence that specific interactions play a role in the cholesterol sensitivity of G protein-coupled receptors. (Geiger J, Sexton R, Al-Sahouri Z, Lee MY, Chun E, Harikumar KG, Miller LJ, Beckstein O, Liu W) Biochim Biophys Acta Biomembr 2021 Sep 01;1863(9):183557 12 Citations |
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1 | Interaction between Mas1 and AT1RA contributes to enhancement of skeletal muscle angiogenesis by angiotensin-(1-7) in Dahl salt-sensitive rats. (Exner EC, Geurts AM, Hoffmann BR, Casati M, Stodola T, Dsouza NR, Zimmermann M, Lombard JH, Greene AS) PLoS One 2020;15(4):e0232067 9 Citations |
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1 | Dorsal Hippocampal Actin Polymerization Is Necessary for Activation of G-Protein-Coupled Estrogen Receptor (GPER) to Increase CA1 Dendritic Spine Density and Enhance Memory Consolidation. (Kim J, Schalk JC, Koss WA, Gremminger RL, Taxier LR, Gross KS, Frick KM) J Neurosci 2019 Nov 27;39(48):9598-9610 40 Citations |
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1 | Solution NMR spectroscopy of GPCRs: Residue-specific labeling strategies with a focus on 13C-methyl methionine labeling of the atypical chemokine receptor ACKR3. (Kleist AB, Peterson F, Tyler RC, Gustavsson M, Handel TM, Volkman BF) Methods Cell Biol 2019;149:259-288 9 Citations |
1 | Structure-activity profiling of alkaloid natural product pharmacophores against a Schistosoma serotonin receptor. (Marchant JS, Harding WW, Chan JD) Int J Parasitol Drugs Drug Resist 2018 Dec;8(3):550-558 13 Citations |
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2 | Loss of FFAR2 promotes colon cancer by epigenetic dysregulation of inflammation suppressors. (Pan P, Oshima K, Huang YW, Agle KA, Drobyski WR, Chen X, Zhang J, Yearsley MM, Yu J, Wang LS) Int J Cancer 2018 Aug 15;143(4):886-896 73 Citations |
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1 | PAR1 agonists stimulate APC-like endothelial cytoprotection and confer resistance to thromboinflammatory injury. (De Ceunynck K, Peters CG, Jain A, Higgins SJ, Aisiku O, Fitch-Tewfik JL, Chaudhry SA, Dockendorff C, Parikh SM, Ingber DE, Flaumenhaft R) Proc Natl Acad Sci U S A 2018 Jan 30;115(5):E982-E991 59 Citations |
1 | An Antimicrobial Peptide and Its Neuronal Receptor Regulate Dendrite Degeneration in Aging and Infection. (E L, Zhou T, Koh S, Chuang M, Sharma R, Pujol N, Chisholm AD, Eroglu C, Matsunami H, Yan D) Neuron 2018 Jan 03;97(1):125-138.e5 74 Citations |
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2 | Genome-Wide Association Study to Find Modifiers for Tetralogy of Fallot in the 22q11.2 Deletion Syndrome Identifies Variants in the GPR98 Locus on 5q14.3. (Guo T, Repetto GM, McDonald McGinn DM, Chung JH, Nomaru H, Campbell CL, Blonska A, Bassett AS, Chow EWC, Mlynarski EE, Swillen A, Vermeesch J, Devriendt K, Gothelf D, Carmel M, Michaelovsky E, Schneider M, Eliez S, Antonarakis SE, Coleman K, Tomita-Mitchell A, Mitchell ME, Digilio MC, Dallapiccola B, Marino B, Philip N, Busa T, Kushan-Wells L, Bearden CE, Piotrowicz M, Hawuła W, Roberts AE, Tassone F, Simon TJ, van Duin EDA, van Amelsvoort TA, Kates WR, Zackai E, Johnston HR, Cutler DJ, Agopian AJ, Goldmuntz E, Mitchell LE, Wang T, Emanuel BS, Morrow BE, International 22q11.2 Consortium/Brain and Behavior Consortium*) Circ Cardiovasc Genet 2017 Oct;10(5):e001690 20 Citations |
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1 | Maternal riboflavin deficiency, resulting in transient neonatal-onset glutaric aciduria Type 2, is caused by a microdeletion in the riboflavin transporter gene GPR172B. (Ho G, Yonezawa A, Masuda S, Inui K, Sim KG, Carpenter K, Olsen RK, Mitchell JJ, Rhead WJ, Peters G, Christodoulou J) Hum Mutat 2011 Jan;32(1):E1976-84 101 Citations |
1 | Characterization of soy-based changes in Wnt-frizzled signaling in prostate cancer. (Liss MA, Schlicht M, Kahler A, Fitzgerald R, Thomassi T, Degueme A, Hessner M, Datta MW) Cancer Genomics Proteomics 2010;7(5):245-52 |
1 | Novel mechanisms in the regulation of G protein-coupled receptor trafficking to the plasma membrane. (Tholanikunnel BG, Joseph K, Kandasamy K, Baldys A, Raymond JR, Luttrell LM, McDermott PJ, Fernandes DJ) J Biol Chem 2010 Oct 29;285(44):33816-25 13 Citations |
1 | Bradykinin decreases podocyte permeability through ADAM17-dependent epidermal growth factor receptor activation and zonula occludens-1 rearrangement. (Dey M, Baldys A, Sumter DB, Göoz P, Luttrell LM, Raymond JR, Göoz M) J Pharmacol Exp Ther 2010 Sep 01;334(3):775-83 33 Citations |
1 | Histidine-rich glycoprotein modulates the anti-angiogenic effects of vasculostatin. (Klenotic PA, Huang P, Palomo J, Kaur B, Van Meir EG, Vogelbaum MA, Febbraio M, Gladson CL, Silverstein RL) Am J Pathol 2010 Apr;176(4):2039-50 46 Citations |
1 | Relaxin-3 and receptors in the human and rhesus brain and reproductive tissues. (Silvertown JD, Neschadim A, Liu HN, Shannon P, Walia JS, Kao JC, Robertson J, Summerlee AJ, Medin JA) Regul Pept 2010 Jan 08;159(1-3):44-53 24 Citations |
1 | Ubiquitination regulates proteolytic processing of G protein-coupled receptors after their sorting to lysosomes. (Hislop JN, Henry AG, Marchese A, von Zastrow M) J Biol Chem 2009 Jul 17;284(29):19361-70 76 Citations |
1 | Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism. (Kaur B, Cork SM, Sandberg EM, Devi NS, Zhang Z, Klenotic PA, Febbraio M, Shim H, Mao H, Tucker-Burden C, Silverstein RL, Brat DJ, Olson JJ, Van Meir EG) Cancer Res 2009 Feb 01;69(3):1212-20 99 Citations |
1 | The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction. (Bhandari D, Robia SL, Marchese A) Mol Biol Cell 2009 Mar;20(5):1324-39 77 Citations |
1 | G protein-coupled receptor sorting to endosomes and lysosomes. (Marchese A, Paing MM, Temple BR, Trejo J) Annu Rev Pharmacol Toxicol 2008;48:601-29 380 Citations |
1 | Cyclic AMP-independent CGRP8-37-sensitive receptors mediate adrenomedullin-induced decrease of CaCl2-contraction in pregnant rat mesenteric artery. (Ross GR, Yallampalli U, Yallampalli C) J Vasc Res 2008;45(1):33-44 4 Citations |
1 | Epistatic interaction between haplotypes of the ghrelin ligand and receptor genes influence susceptibility to myocardial infarction and coronary artery disease. (Baessler A, Fischer M, Mayer B, Koehler M, Wiedmann S, Stark K, Doering A, Erdmann J, Riegger G, Schunkert H, Kwitek AE, Hengstenberg C) Hum Mol Genet 2007 Apr 15;16(8):887-99 37 Citations |
2 | An engineered second disulfide bond restricts lymphotactin/XCL1 to a chemokine-like conformation with XCR1 agonist activity. (Tuinstra RL, Peterson FC, Elgin ES, Pelzek AJ, Volkman BF) Biochemistry 2007 Mar 13;46(10):2564-73 52 Citations |
1 | Adrenomedullin-2, a novel calcitonin/calcitonin-gene-related peptide family peptide, relaxes rat mesenteric artery: influence of pregnancy. (Chauhan M, Ross GR, Yallampalli U, Yallampalli C) Endocrinology 2007 Apr;148(4):1727-35 38 Citations |
1 | Differential helical orientations among related G protein-coupled receptors provide a novel mechanism for selectivity. Studies with salvinorin A and the kappa-opioid receptor. (Vortherms TA, Mosier PD, Westkaemper RB, Roth BL) J Biol Chem 2007 Feb 02;282(5):3146-56 34 Citations |
1 | Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7). (Grobe JL, Mecca AP, Lingis M, Shenoy V, Bolton TA, Machado JM, Speth RC, Raizada MK, Katovich MJ) Am J Physiol Heart Circ Physiol 2007 Feb;292(2):H736-42 315 Citations |
1 | Association of the Ghrelin receptor gene region with left ventricular hypertrophy in the general population: results of the MONICA/KORA Augsburg Echocardiographic Substudy. (Baessler A, Kwitek AE, Fischer M, Koehler M, Reinhard W, Erdmann J, Riegger G, Doering A, Schunkert H, Hengstenberg C) Hypertension 2006 May;47(5):920-7 26 Citations |
1 | Genetic linkage and association of the growth hormone secretagogue receptor (ghrelin receptor) gene in human obesity. (Baessler A, Hasinoff MJ, Fischer M, Reinhard W, Sonnenberg GE, Olivier M, Erdmann J, Schunkert H, Doering A, Jacob HJ, Comuzzie AG, Kissebah AH, Kwitek AE) Diabetes 2005 Jan;54(1):259-67 85 Citations |
1 | Ubiquitination of G-protein-coupled receptors. (Marchese A, Benovic JL) Methods Mol Biol 2004;259:299-305 15 Citations |
1 | Professor Robert J. Lefkowitz, M.D., scientist and mentor extraordinaire. (Inglese J, Raymond JR) Assay Drug Dev Technol 2003 Apr;1(2):227-31 |
1 | Expression of G-protein alpha subunit genes in the vestibular periphery of Rattus norvegicus and their chromosomal mapping. (Cioffi JA, Erbe CB, Raphael R, Kwitek AE, Tiwari UK, Jacob HJ, Popper P, Wackym PA) Acta Otolaryngol 2003 Dec;123(9):1027-34 7 Citations |
1 | Dual regulation of cryptochrome 1 mRNA expression in chicken retina by light and circadian oscillators. (Haque R, Chaurasia SS, Wessel JH 3rd, Iuvone PM) Neuroreport 2002 Dec 03;13(17):2247-51 93 Citations |
1 | Platelet-activating factor priming of inflammatory cell activity requires cellular adherence. (Cuschieri J, Gourlay D, Bulger E, Garcia I, Jelacic S, Maier RV) Surgery 2002 Aug;132(2):157-66 7 Citations |
1 | Molecular cloning, tissue-specific expression, and chromosomal localization of a novel nerve growth factor-regulated G-protein- coupled receptor, nrg-1. (Glickman M, Malek RL, Kwitek-Black AE, Jacob HJ, Lee NH) Mol Cell Neurosci 1999 Aug;14(2):141-52 67 Citations |
1 | Human intestinal epithelial cells express receptors for platelet-activating factor. (Merendino N, Dwinell MB, Varki N, Eckmann L, Kagnoff MF) Am J Physiol 1999 Oct;277(4):G810-8 23 Citations |
1 | The heterotrimeric G protein G alpha i2 mediates lysophosphatidic acid-stimulated induction of the c-fos gene in mouse fibroblasts. (Chuprun JK, Raymond JR, Blackshear PJ) J Biol Chem 1997 Jan 10;272(2):773-81 33 Citations |
1 | G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism. (van Biesen T, Hawes BE, Raymond JR, Luttrell LM, Koch WJ, Lefkowitz RJ) J Biol Chem 1996 Jan 19;271(3):1266-9 190 Citations |
1 | Tulopafant, a PAF receptor antagonist, increases capillary patency and prolongs survival in discordant cardiac xenotransplants. (O'Hair DP, Roza AM, Komorowski R, Moore G, McManus RP, Johnson CP, Adams MB, Pieper GM) J Lipid Mediat 1993 May;7(1):79-84 11 Citations |