Medical College of Wisconsin
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Alison J. Kriegel PhD

Alison J. Kriegel PhD profile photo picture

Associate Professor

Institution: Medical College of Wisconsin
Department: Physiology

Member of the Cancer Center
Member of the Cardiovascular Center

View Curriculum Vitae

Research Experience

  • Cardiovascular Physiological Phenomena
  • Cell Communication
  • Cell Physiological Phenomena
  • Paracrine Communication
  • MicroRNA
  • Molecular Biology
  • Physiological Genomics
  • Hypertension
  • Renal Physiology

    • Methodologies and Techniques

  • RNA analysis
  • Models of Renal Pathology
  • qRT-PCR
  • miRNA analysis
  • Rodent Left Ventricle Pressure-Volume Loop Analysis
  • Models of Cardiac Pathology
  • Next-generation RNA Sequencing
  • Rodent Echocardiography
  • Western Blot

    • Publications (45)

  • Broad-acting therapeutic effects of miR-29b-chitosan on hypertension and diabetic complications. (Jensen DM, Han P, Mangala LS, Lopez-Berestein G, Sood AK, Liu J, Kriegel AJ, Usa K, Widlansky ME, Liang M) Mol Ther 2022 Nov 02;30(11):3462-3476 PMID: 35965413 PMCID: PMC9637778 SCOPUS ID: 2-s2.0-85136662053 08/16/2022       8 Citations
  • Fetal pulmonary hypertension: dysregulated microRNA-34c-Notch1 axis contributes to impaired angiogenesis in an ovine model. (Mukherjee D, Rana U, Kriegel AJ, Liu P, Michalkiewicz T, Konduri GG) Pediatr Res 2023 Feb;93(3):551-558 PMID: 35717485 PMCID: PMC9759620 SCOPUS ID: 2-s2.0-85132167802 06/19/2022    
  • Effects of elevation of ANP and its deficiency on cardiorenal function. (Ilatovskaya DV, Levchenko V, Winsor K, Blass GR, Spires DR, Sarsenova E, Polina I, Zietara A, Paterson M, Kriegel AJ, Staruschenko A) JCI Insight 2022 May 09;7(9) PMID: 35380994 PMCID: PMC9090260 SCOPUS ID: 2-s2.0-85129984120 04/06/2022       8 Citations
  • Comparison of the surgical resection and infarct 5/6 nephrectomy rat models of chronic kidney disease. (Adam RJ, Williams AC, Kriegel AJ) Am J Physiol Renal Physiol 2022 Jun 01;322(6):F639-F654 PMID: 35379002 PMCID: PMC9076416 SCOPUS ID: 2-s2.0-85129997035 04/06/2022       8 Citations
  • Cardiometabolic effects of DOCA-salt in male C57BL/6J mice are variably dependent on sodium and nonsodium components of diet. (Patil CN, Ritter ML, Wackman KK, Oliveira V, Balapattabi K, Grobe CC, Brozoski DT, Reho JJ, Nakagawa P, Mouradian GC Jr, Kriegel AJ, Kwitek AE, Hodges MR, Segar JL, Sigmund CD, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2022 Jun 01;322(6):R467-R485 PMID: 35348007 PMCID: PMC9054347 SCOPUS ID: 2-s2.0-85129779185 03/30/2022       6 Citations
  • System-wide transcriptome damage and tissue identity loss in COVID-19 patients. (Park J, Foox J, Hether T, Danko DC, Warren S, Kim Y, Reeves J, Butler DJ, Mozsary C, Rosiene J, Shaiber A, Afshin EE, MacKay M, Rendeiro AF, Bram Y, Chandar V, Geiger H, Craney A, Velu P, Melnick AM, Hajirasouliha I, Beheshti A, Taylor D, Saravia-Butler A, Singh U, Wurtele ES, Schisler J, Fennessey S, Corvelo A, Zody MC, Germer S, Salvatore S, Levy S, Wu S, Tatonetti NP, Shapira S, Salvatore M, Westblade LF, Cushing M, Rennert H, Kriegel AJ, Elemento O, Imielinski M, Rice CM, Borczuk AC, Meydan C, Schwartz RE, Mason CE) Cell Rep Med 2022 Feb 15;3(2):100522 PMID: 35233546 PMCID: PMC8784611 SCOPUS ID: 2-s2.0-85124273639 03/03/2022       23 Citations
  • Acclimation to a High-Salt Diet Is Sex Dependent. (Gohar EY, De Miguel C, Obi IE, Daugherty EM, Hyndman KA, Becker BK, Jin C, Sedaka R, Johnston JG, Liu P, Speed JS, Mitchell T, Kriegel AJ, Pollock JS, Pollock DM) J Am Heart Assoc 2022 Mar;11(5):e020450 PMID: 35191321 PMCID: PMC9075092 SCOPUS ID: 2-s2.0-85125554109 02/23/2022       15 Citations
  • System-wide transcriptome damage and tissue identity loss in COVID-19 patients (Park J, Foox J, Hether T, Danko DC, Warren S, Kim Y, Reeves J, Butler DJ, Mozsary C, Rosiene J, Shaiber A, Afshin EE, MacKay M, Rendeiro AF, Bram Y, Chandar V, Geiger H, Craney A, Velu P, Melnick AM, Hajirasouliha I, Beheshti A, Taylor D, Saravia-Butler A, Singh U, Wurtele ES, Schisler J, Fennessey S, Corvelo A, Zody MC, Germer S, Salvatore S, Levy S, Wu S, Tatonetti NP, Shapira S, Salvatore M, Westblade LF, Cushing M, Rennert H, Kriegel AJ, Elemento O, Imielinski M, Rice CM, Borczuk AC, Meydan C, Schwartz RE, Mason CE) Cell Reports Medicine 15 February 2022;3(2) SCOPUS ID: 2-s2.0-85124273639 02/15/2022       23 Citations
  • Loop-Mediated Isothermal Amplification Detection of SARS-CoV-2 and Myriad Other Applications. (Moore KJM, Cahill J, Aidelberg G, Aronoff R, Bektaş A, Bezdan D, Butler DJ, Chittur SV, Codyre M, Federici F, Tanner NA, Tighe SW, True R, Ware SB, Wyllie AL, Afshin EE, Bendesky A, Chang CB, Dela Rosa R 2nd, Elhaik E, Erickson D, Goldsborough AS, Grills G, Hadasch K, Hayden A, Her SY, Karl JA, Kim CH, Kriegel AJ, Kunstman T, Landau Z, Land K, Langhorst BW, Lindner AB, Mayer BE, McLaughlin LA, McLaughlin MT, Molloy J, Mozsary C, Nadler JL, D'Silva M, Ng D, O'Connor DH, Ongerth JE, Osuolale O, Pinharanda A, Plenker D, Ranjan R, Rosbash M, Rotem A, Segarra J, Schürer S, Sherrill-Mix S, Solo-Gabriele H, To S, Vogt MC, Yu AD, Mason CE, gLAMP Consortium) J Biomol Tech 2021 Sep;32(3):228-275 PMID: 35136384 PMCID: PMC8802757 SCOPUS ID: 2-s2.0-85124281562 02/10/2022       26 Citations
  • Functionally Essential Tubular Proteins Are Lost to Urine-Excreted, Large Extracellular Vesicles during Chronic Renal Insufficiency. (Adam RJ, Paterson MR, Wardecke L, Hoffmann BR, Kriegel AJ) Kidney360 2020 Oct;1(10):1105-1115 PMID: 34263177 PMCID: PMC8276873 07/16/2021    
  • Sexual dimorphism in the progression of type 2 diabetic kidney disease in T2DN rats. (Spires DR, Palygin O, Levchenko V, Isaeva E, Klemens CA, Khedr S, Nikolaienko O, Kriegel A, Cheng X, Yeo JY, Joe B, Staruschenko A) Physiol Genomics 2021 Jun 01;53(6):223-234 PMID: 33870721 PMCID: PMC8285576 SCOPUS ID: 2-s2.0-85108022875 04/20/2021       8 Citations
  • Systemic Tissue and Cellular Disruption from SARS-CoV-2 Infection revealed in COVID-19 Autopsies and Spatial Omics Tissue Maps. (Park J, Foox J, Hether T, Danko D, Warren S, Kim Y, Reeves J, Butler DJ, Mozsary C, Rosiene J, Shaiber A, Afshinnekoo E, MacKay M, Bram Y, Chandar V, Geiger H, Craney A, Velu P, Melnick AM, Hajirasouliha I, Beheshti A, Taylor D, Saravia-Butler A, Singh U, Wurtele ES, Schisler J, Fennessey S, Corvelo A, Zody MC, Germer S, Salvatore S, Levy S, Wu S, Tatonetti N, Shapira S, Salvatore M, Loda M, Westblade LF, Cushing M, Rennert H, Kriegel AJ, Elemento O, Imielinski M, Borczuk AC, Meydan C, Schwartz RE, Mason CE) bioRxiv 2021 Mar 09 PMID: 33758858 PMCID: PMC7987017 03/25/2021    
  • Loss of Chloride Channel 6 (CLC-6) Affects Vascular Smooth Muscle Contractility and Arterial Stiffness via Alterations to Golgi Calcium Stores. (Klemens CA, Chulkov EG, Wu J, Hye Khan MA, Levchenko V, Flister MJ, Imig JD, Kriegel AJ, Palygin O, Staruschenko A) Hypertension 2021 Feb;77(2):582-593 PMID: 33390052 PMCID: PMC7856014 SCOPUS ID: 2-s2.0-85100070512 01/05/2021       7 Citations
  • The COVID-19 XPRIZE and the need for scalable, fast, and widespread testing. (MacKay MJ, Hooker AC, Afshinnekoo E, Salit M, Kelly J, Feldstein JV, Haft N, Schenkel D, Nambi S, Cai Y, Zhang F, Church G, Dai J, Wang CL, Levy S, Huber J, Ji HP, Kriegel A, Wyllie AL, Mason CE) Nat Biotechnol 2020 Sep;38(9):1021-1024 PMID: 32820257 PMCID: PMC7543743 SCOPUS ID: 2-s2.0-85089701507 08/21/2020       56 Citations
  • miR-146b-5p has a sex-specific role in renal and cardiac pathology in a rat model of chronic kidney disease. (Paterson MR, Geurts AM, Kriegel AJ) Kidney Int 2019 Dec;96(6):1332-1345 PMID: 31668631 PMCID: PMC6941490 SCOPUS ID: 2-s2.0-85074541202 11/02/2019       30 Citations
  • Dietary Effects on Dahl Salt-Sensitive Hypertension, Renal Damage, and the T Lymphocyte Transcriptome. (Abais-Battad JM, Alsheikh AJ, Pan X, Fehrenbach DJ, Dasinger JH, Lund H, Roberts ML, Kriegel AJ, Cowley AW Jr, Kidambi S, Kotchen TA, Liu P, Liang M, Mattson DL) Hypertension 2019 Oct;74(4):854-863 PMID: 31476910 PMCID: PMC6739138 SCOPUS ID: 2-s2.0-85072134357 09/04/2019       30 Citations
  • Detrimental effects of chemotherapy on human coronary microvascular function. (Hader SN, Zinkevich N, Norwood Toro LE, Kriegel AJ, Kong A, Freed JK, Gutterman DD, Beyer AM) Am J Physiol Heart Circ Physiol 2019 Oct 01;317(4):H705-H710 PMID: 31397169 PMCID: PMC6843017 SCOPUS ID: 2-s2.0-85072508643 08/10/2019       26 Citations
  • Adverse early-life environment impairs postnatal lung development in mice. (Lai PY, Jing X, Michalkiewicz T, Entringer B, Ke X, Majnik A, Kriegel AJ, Liu P, Lane RH, Konduri GG) Physiol Genomics 2019 Sep 01;51(9):462-470 PMID: 31373541 PMCID: PMC6766700 SCOPUS ID: 2-s2.0-85072265843 08/03/2019       11 Citations
  • Library Preparation for Multiplexed Reduced Representation Bisulfite Sequencing with a Universal Adapter. (Liu Y, Kriegel AJ, Liang M) Methods Mol Biol 2019;2018:177-194 PMID: 31228157 SCOPUS ID: 2-s2.0-85068180336 06/23/2019       3 Citations
  • Salt-deficient diet exacerbates cystogenesis in ARPKD via epithelial sodium channel (ENaC). (Ilatovskaya DV, Levchenko V, Pavlov TS, Isaeva E, Klemens CA, Johnson J, Liu P, Kriegel AJ, Staruschenko A) EBioMedicine 2019 Feb;40:663-674 PMID: 30745171 PMCID: PMC6413684 SCOPUS ID: 2-s2.0-85061112508 02/13/2019       24 Citations
  • miR-21-5p regulates mitochondrial respiration and lipid content in H9C2 cells. (Nasci VL, Chuppa S, Griswold L, Goodreau KA, Dash RK, Kriegel AJ) Am J Physiol Heart Circ Physiol 2019 Mar 01;316(3):H710-H721 PMID: 30657727 PMCID: PMC6459316 SCOPUS ID: 2-s2.0-85062599405 01/19/2019       36 Citations
  • MiR-192-5p in the Kidney Protects Against the Development of Hypertension. (Baker MA, Wang F, Liu Y, Kriegel AJ, Geurts AM, Usa K, Xue H, Wang D, Kong Y, Liang M) Hypertension 2019 Feb;73(2):399-406 PMID: 30595117 PMCID: PMC6339564 SCOPUS ID: 2-s2.0-85059796489 01/01/2019       42 Citations
  • Isomer-specific effect of microRNA miR-29b on nuclear morphology. (Kriegel AJ, Terhune SS, Greene AS, Noon KR, Pereckas MS, Liang M) J Biol Chem 2018 Sep 07;293(36):14080-14088 PMID: 30006350 PMCID: PMC6130969 SCOPUS ID: 2-s2.0-85053013199 07/15/2018       12 Citations
  • α-Galactosidase A-deficient rats accumulate glycosphingolipids and develop cardiorenal phenotypes of Fabry disease. (Miller JJ, Aoki K, Mascari CA, Beltrame AK, Sokumbi O, North PE, Tiemeyer M, Kriegel AJ, Dahms NM) FASEB J 2019 Jan;33(1):418-429 PMID: 29979634 PMCID: PMC6629127 SCOPUS ID: 2-s2.0-85059237456 07/07/2018       20 Citations
  • miR-29 contributes to normal endothelial function and can restore it in cardiometabolic disorders. (Widlansky ME, Jensen DM, Wang J, Liu Y, Geurts AM, Kriegel AJ, Liu P, Ying R, Zhang G, Casati M, Chu C, Malik M, Branum A, Tanner MJ, Tyagi S, Usa K, Liang M) EMBO Mol Med 2018 Mar;10(3) PMID: 29374012 PMCID: PMC5840545 SCOPUS ID: 2-s2.0-85041063208 01/28/2018       72 Citations
  • MicroRNA-21 regulates peroxisome proliferator-activated receptor alpha, a molecular mechanism of cardiac pathology in Cardiorenal Syndrome Type 4. (Chuppa S, Liang M, Liu P, Liu Y, Casati MC, Cowley AW, Patullo L, Kriegel AJ) Kidney Int 2018 Feb;93(2):375-389 PMID: 28760335 PMCID: PMC5787401 SCOPUS ID: 2-s2.0-85026463717 08/02/2017       65 Citations
  • MiR-146a/b: a family with shared seeds and different roots. (Paterson MR, Kriegel AJ) Physiol Genomics 2017 Apr 01;49(4):243-252 PMID: 28213571 PMCID: PMC5407182 SCOPUS ID: 2-s2.0-85018520006 02/19/2017       100 Citations
  • Renal Delivery of Anti-microRNA Oligonucleotides in Rats. (Usa KS, Liu Y, Kurth T, Kriegel AJ, Mattson DL, Cowley AW Jr, Liang M) Methods Mol Biol 2017;1527:409-419 PMID: 28116733 SCOPUS ID: 2-s2.0-85011003449 01/25/2017    
  • Molecular Approaches in HFpEF: MicroRNAs and iPSC-Derived Cardiomyocytes. (Kriegel AJ, Gartz M, Afzal MZ, de Lange WJ, Ralphe JC, Strande JL) J Cardiovasc Transl Res 2017 Jun;10(3):295-304 PMID: 28032312 PMCID: PMC5937699 SCOPUS ID: 2-s2.0-85007413634 12/30/2016       9 Citations
  • Endogenous microRNAs in human microvascular endothelial cells regulate mRNAs encoded by hypertension-related genes. (Kriegel AJ, Baker MA, Liu Y, Liu P, Cowley AW Jr, Liang M) Hypertension 2015 Oct;66(4):793-9 PMID: 26283043 PMCID: PMC4567475 SCOPUS ID: 2-s2.0-84941199042 08/19/2015       87 Citations
  • Up-regulation of microRNA-21 mediates isoflurane-induced protection of cardiomyocytes. (Olson JM, Yan Y, Bai X, Ge ZD, Liang M, Kriegel AJ, Twaroski DM, Bosnjak ZJ) Anesthesiology 2015 Apr;122(4):795-805 PMID: 25536091 PMCID: PMC4366274 SCOPUS ID: 2-s2.0-84937250884 12/24/2014       45 Citations
  • miR-21 in ischemia/reperfusion injury: a double-edged sword? (Xu X, Kriegel AJ, Jiao X, Liu H, Bai X, Olson J, Liang M, Ding X) Physiol Genomics 2014 Nov 01;46(21):789-97 PMID: 25159851 PMCID: PMC4280148 SCOPUS ID: 2-s2.0-84908453071 08/28/2014       88 Citations
  • MicroRNA in situ hybridization for formalin fixed kidney tissues. (Kriegel AJ, Liang M) J Vis Exp 2013 Nov 30(81) PMID: 24326287 PMCID: PMC3992125 SCOPUS ID: 2-s2.0-84888876317 12/12/2013       12 Citations
  • Characteristics of microRNAs enriched in specific cell types and primary tissue types in solid organs. (Kriegel AJ, Liu Y, Liu P, Baker MA, Hodges MR, Hua X, Liang M) Physiol Genomics 2013 Dec 01;45(23):1144-56 PMID: 24085797 PMCID: PMC3882707 SCOPUS ID: 2-s2.0-84888802105 10/03/2013       29 Citations
  • Intermittent exposure to xenon protects against gentamicin-induced nephrotoxicity. (Jia P, Teng J, Zou J, Fang Y, Jiang S, Yu X, Kriegel AJ, Liang M, Ding X) PLoS One 2013;8(5):e64329 PMID: 23737979 PMCID: PMC3667819 SCOPUS ID: 2-s2.0-84878490659 06/06/2013       34 Citations
  • Hypoxic preconditioning with cobalt of bone marrow mesenchymal stem cells improves cell migration and enhances therapy for treatment of ischemic acute kidney injury. (Yu X, Lu C, Liu H, Rao S, Cai J, Liu S, Kriegel AJ, Greene AS, Liang M, Ding X) PLoS One 2013;8(5):e62703 PMID: 23671625 PMCID: PMC3650042 SCOPUS ID: 2-s2.0-84877330228 05/15/2013       80 Citations
  • miR-29c is downregulated in renal interstitial fibrosis in humans and rats and restored by HIF-α activation. (Fang Y, Yu X, Liu Y, Kriegel AJ, Heng Y, Xu X, Liang M, Ding X) Am J Physiol Renal Physiol 2013 May 15;304(10):F1274-82 PMID: 23467423 PMCID: PMC3651624 SCOPUS ID: 2-s2.0-84878641501 03/08/2013       109 Citations
  • Delayed ischemic preconditioning contributes to renal protection by upregulation of miR-21. (Xu X, Kriegel AJ, Liu Y, Usa K, Mladinov D, Liu H, Fang Y, Ding X, Liang M) Kidney Int 2012 Dec;82(11):1167-75 PMID: 22785173 PMCID: PMC3777822 SCOPUS ID: 2-s2.0-84869212341 07/13/2012       148 Citations
  • Mechanisms of cardioprotection resulting from Brown Norway chromosome 16 substitution in the salt-sensitive Dahl rat. (Kriegel AJ, Didier DN, Li P, Lazar J, Greene AS) Physiol Genomics 2012 Aug 17;44(16):819-27 PMID: 22759922 PMCID: PMC3774569 SCOPUS ID: 2-s2.0-84865817728 07/05/2012       5 Citations
  • Translational study of microRNAs and its application in kidney disease and hypertension research. (Kriegel AJ, Mladinov D, Liang M) Clin Sci (Lond) 2012 May 01;122(10):439-47 PMID: 22283365 PMCID: PMC4428581 SCOPUS ID: 2-s2.0-84858729145 01/31/2012       16 Citations
  • The miR-29 family: genomics, cell biology, and relevance to renal and cardiovascular injury. (Kriegel AJ, Liu Y, Fang Y, Ding X, Liang M) Physiol Genomics 2012 Feb 27;44(4):237-44 PMID: 22214600 PMCID: PMC3289120 SCOPUS ID: 2-s2.0-84863230332 01/05/2012       418 Citations
  • MiR-382 targeting of kallikrein 5 contributes to renal inner medullary interstitial fibrosis. (Kriegel AJ, Liu Y, Cohen B, Usa K, Liu Y, Liang M) Physiol Genomics 2012 Feb 27;44(4):259-67 PMID: 22202692 PMCID: PMC3289118 SCOPUS ID: 2-s2.0-84863229877 12/29/2011       75 Citations
  • MicroRNA-target pairs in human renal epithelial cells treated with transforming growth factor beta 1: a novel role of miR-382. (Kriegel AJ, Fang Y, Liu Y, Tian Z, Mladinov D, Matus IR, Ding X, Greene AS, Liang M) Nucleic Acids Res 2010 Dec;38(22):8338-47 PMID: 20716515 PMCID: PMC3001085 SCOPUS ID: 2-s2.0-78650470110 08/19/2010       107 Citations
  • Substitution of Brown Norway chromosome 16 preserves cardiac function with aging in a salt-sensitive Dahl consomic rat. (Kriegel AJ, Greene AS) Physiol Genomics 2008 Dec 12;36(1):35-42 PMID: 18940898 PMCID: PMC2604784 SCOPUS ID: 2-s2.0-57749092868 10/23/2008       12 Citations
  • Combined effects of low-dose spironolactone and captopril therapy in a rat model of genetic hypertrophic cardiomyopathy. (de Resende MM, Kriegel AJ, Greene AS) J Cardiovasc Pharmacol 2006 Dec;48(6):265-73 PMID: 17204904 SCOPUS ID: 2-s2.0-33846045553 01/06/2007       28 Citations
    • Last update: 11/08/2022