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Kevin R. Regner MD

Kevin R. Regner MD profile photo picture

Chief, Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Nephrology
Program: Administration

Member of the Cardiovascular Center
Member of the Genomic Sciences and Precision Medicine Center (GSPMC)

View Curriculum Vitae

Research Experience

  • Hemofiltration
  • Kidney Failure, Chronic
  • Kidney Tubular Necrosis, Acute
  • Kidney Tubules, Proximal
  • Renal Replacement Therapy

  • Publications (45)

  • p66Shc signaling does not contribute to tubular damage induced by renal ischemia-reperfusion injury in rat (Miller B, Regner K, Sorokin A) Biochemical and Biophysical Research Communications 7 May 2022;603:69-74 SCOPUS ID: 2-s2.0-85125835040 05/07/2022    
  • Cannabinoid Type 2 Receptor Activation Reduces the Progression of Kidney Fibrosis Using a Mouse Model of Unilateral Ureteral Obstruction. (Swanson ML, Regner KR, Moore BM, Park F) Cannabis Cannabinoid Res 2022 Feb 23 PMID: 35196117 02/24/2022    
  • Histologically resolved small RNA maps in primary focal segmental glomerulosclerosis indicate progressive changes within glomerular and tubulointerstitial regions. (Williams AM, Jensen DM, Pan X, Liu P, Liu J, Huls S, Regner KR, Iczkowski KA, Wang F, Li J, Gallan AJ, Wang T, Baker MA, Liu Y, Lalehzari N, Liang M) Kidney Int 2022 04;101(4):766-778 PMID: 35114200 PMCID: PMC8940673 SCOPUS ID: 2-s2.0-85125312317 02/04/2022    
  • DNA damage is overcome by TRIP13 overexpression during cisplatin nephrotoxicity. (Hama T, Nagesh PK, Chowdhury P, Moore BM 2nd, Yallapu MM, Regner KR, Park F) JCI Insight 2021 11 22;6(22) PMID: 34806647 PMCID: PMC8663775 SCOPUS ID: 2-s2.0-85120382452 11/23/2021    
  • DNA damage is overcome by TRIP13 overexpression during cisplatin nephrotoxicity (Hama T, Nagesh PKB, Chowdhury P, Moore BM, Yallapu MM, Regner KR, Park F) JCI Insight 22 November 2021;6(22) SCOPUS ID: 2-s2.0-85120382452 11/22/2021    
  • Terlipressin and the Treatment of Hepatorenal Syndrome: How the CONFIRM Trial Moves the Story Forward. (Belcher JM, Parada XV, Simonetto DA, Juncos LA, Karakala N, Wadei HM, Sharma P, Regner KR, Nadim MK, Garcia-Tsao G, Velez JCQ, Parikh SM, Chung RT, Allegretti AS, HRS-HARMONY Study Investigators) Am J Kidney Dis 2022 May;79(5):737-745 PMID: 34606933 SCOPUS ID: 2-s2.0-85122545748 10/05/2021    
  • Urinary NGAL as a Diagnostic and Prognostic Marker for Acute Kidney Injury in Cirrhosis: A Prospective Study. (Allegretti AS, Parada XV, Endres P, Zhao S, Krinsky S, St Hillien SA, Kalim S, Nigwekar SU, Flood JG, Nixon A, Simonetto DA, Juncos LA, Karakala N, Wadei HM, Regner KR, Belcher JM, Nadim MK, Garcia-Tsao G, Velez JCQ, Parikh SM, Chung RT, HRS-HARMONY study investigators) Clin Transl Gastroenterol 2021 05 11;12(5):e00359 PMID: 33979307 PMCID: PMC8116001 SCOPUS ID: 2-s2.0-85105838703 05/13/2021       11 Citations
  • Endogenous miR-204 Protects the Kidney against Chronic Injury in Hypertension and Diabetes. (Cheng Y, Wang D, Wang F, Liu J, Huang B, Baker MA, Yin J, Wu R, Liu X, Regner KR, Usa K, Liu Y, Zhang C, Dong L, Geurts AM, Wang N, Miller SS, He Y, Liang M) J Am Soc Nephrol 2020 07;31(7):1539-1554 PMID: 32487559 PMCID: PMC7350998 SCOPUS ID: 2-s2.0-85087468924 06/04/2020       20 Citations
  • MicroRNA-214-3p in the Kidney Contributes to the Development of Hypertension. (Liu Y, Usa K, Wang F, Liu P, Geurts AM, Li J, Williams AM, Regner KR, Kong Y, Liu H, Nie J, Liang M) J Am Soc Nephrol 2018 10;29(10):2518-2528 PMID: 30049682 PMCID: PMC6171279 SCOPUS ID: 2-s2.0-85053979457 07/28/2018       32 Citations
  • Urinary exosomal expression of activator of G protein signaling 3 in polycystic kidney disease. (Keri KC, Regner KR, Dall AT, Park F) BMC Res Notes 2018 Jun 07;11(1):359 PMID: 29880041 PMCID: PMC5992714 SCOPUS ID: 2-s2.0-85048187272 06/09/2018       13 Citations
  • Artificial intelligence, physiological genomics, and precision medicine. (Williams AM, Liu Y, Regner KR, Jotterand F, Liu P, Liang M) Physiol Genomics 2018 04 01;50(4):237-243 PMID: 29373082 PMCID: PMC5966805 SCOPUS ID: 2-s2.0-85046104804 01/27/2018       55 Citations
  • Tissue-Specific MicroRNA Expression Patterns in Four Types of Kidney Disease. (Baker MA, Davis SJ, Liu P, Pan X, Williams AM, Iczkowski KA, Gallagher ST, Bishop K, Regner KR, Liu Y, Liang M) J Am Soc Nephrol 2017 Oct;28(10):2985-2992 PMID: 28663230 PMCID: PMC5619963 SCOPUS ID: 2-s2.0-85030470491 07/01/2017       64 Citations
  • TRIP13-deficient tubular epithelial cells are susceptible to apoptosis following acute kidney injury. (Pressly JD, Hama T, Brien SO, Regner KR, Park F) Sci Rep 2017 03 03;7:43196 PMID: 28256593 PMCID: PMC5335694 SCOPUS ID: 2-s2.0-85014629995 03/04/2017       9 Citations
  • Outcome analysis of continuous intraoperative renal replacement therapy in the highest acuity liver transplant recipients: A single-center experience. (Zimmerman MA, Selim M, Kim J, Regner K, Saeian K, Zanowski S, Martin A, Connolly LA, Lauer KK, Woehlck HJ, Hong JC) Surgery 2017 05;161(5):1279-1286 PMID: 28011008 SCOPUS ID: 2-s2.0-85008237865 12/25/2016       18 Citations
  • Kidney Injury in Liver Disease. (Regner KR, Singbartl K) Crit Care Clin 2016 Jul;32(3):343-55 PMID: 27339675 SCOPUS ID: 2-s2.0-84974805097 06/25/2016       18 Citations
  • Deficiency in the Formation of 20-Hydroxyeicosatetraenoic Acid Enhances Renal Ischemia-Reperfusion Injury. (Muroya Y, Fan F, Regner KR, Falck JR, Garrett MR, Juncos LA, Roman RJ) J Am Soc Nephrol 2015 Oct;26(10):2460-9 PMID: 25644108 PMCID: PMC4587700 SCOPUS ID: 2-s2.0-84942938562 02/04/2015       18 Citations
  • Activator of G-protein Signaling 3 Controls Renal Epithelial Cell Survival and ERK5 Activation. (Rasmussen SA, Kwon M, Pressly JD, Blumer JB, Regner KR, Park F) J Mol Signal 2015 Nov 27;10:6 PMID: 27096004 PMCID: PMC4831271 SCOPUS ID: 2-s2.0-84988694039 01/01/2015       3 Citations
  • Localization and expression profile of Group I and II Activators of G-protein Signaling in the kidney. (Lenarczyk M, Pressly JD, Arnett J, Regner KR, Park F) J Mol Histol 2015 Apr;46(2):123-36 PMID: 25533045 PMCID: PMC4369180 SCOPUS ID: 2-s2.0-84925517942 12/24/2014       11 Citations
  • G-protein βγ subunit dimers modulate kidney repair after ischemia-reperfusion injury in rats. (White SM, North LM, Haines E, Goldberg M, Sullivan LM, Pressly JD, Weber DS, Park F, Regner KR) Mol Pharmacol 2014 Oct;86(4):369-77 PMID: 25028481 PMCID: PMC4164983 SCOPUS ID: 2-s2.0-84907912300 07/17/2014       12 Citations
  • De novo expression of sodium-glucose cotransporter SGLT2 in Bowman's capsule coincides with replacement of parietal epithelial cell layer with proximal tubule-like epithelium. (Tabatabai NM, North PE, Regner KR, Kumar SN, Duris CB, Blodgett AB) J Membr Biol 2014 Aug;247(8):675-83 PMID: 24906870 PMCID: PMC4117812 SCOPUS ID: 2-s2.0-84905576038 06/08/2014       6 Citations
  • Genetic susceptibility and loss of Nr4a1 enhances macrophage-mediated renal injury in CKD. (Westbrook L, Johnson AC, Regner KR, Williams JM, Mattson DL, Kyle PB, Henegar JR, Garrett MR) J Am Soc Nephrol 2014 Nov;25(11):2499-510 PMID: 24722447 PMCID: PMC4214519 SCOPUS ID: 2-s2.0-84920983217 04/12/2014       20 Citations
  • Phenytoin removal by continuous venovenous hemofiltration. (Oltrogge KM, Peppard WJ, Saleh M, Regner KR, Herrmann DJ) Ann Pharmacother 2013 Sep;47(9):1218-22 PMID: 24259740 SCOPUS ID: 2-s2.0-84884491746 11/22/2013       12 Citations
  • Approach to the patient with hematuria (Ratkalkar VN, Regner KR) Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation 1 November 2013:43-49 SCOPUS ID: 2-s2.0-84929538735 11/01/2013    
  • Genetic variants in Arhgef11 are associated with kidney injury in the Dahl salt-sensitive rat. (Williams JM, Johnson AC, Stelloh C, Dreisbach AW, Franceschini N, Regner KR, Townsend RR, Roman RJ, Garrett MR) Hypertension 2012 Nov;60(5):1157-68 PMID: 22987919 PMCID: PMC3505884 SCOPUS ID: 2-s2.0-84868200082 09/19/2012       25 Citations
  • Increased susceptibility to kidney injury by transfer of genomic segment from SHR onto Dahl S genetic background. (Regner KR, Harmon AC, Williams JM, Stelloh C, Johnson AC, Kyle PB, Lerch-Gaggl A, White SM, Garrett MR) Physiol Genomics 2012 Jun 15;44(12):629-37 PMID: 22548739 PMCID: PMC3426430 SCOPUS ID: 2-s2.0-84862628928 05/03/2012       11 Citations
  • Urinary interleukin-18 and urinary neutrophil gelatinase-associated lipocalin predict acute kidney injury following pulmonary valve replacement prior to serum creatinine. (Buelow MW, Dall A, Regner K, Weinberg C, Bartz PJ, Sowinski J, Rudd N, Katzmark L, Tweddell JS, Earing MG) Congenit Heart Dis 2012 Sep-Oct;7(5):441-7 PMID: 22537138 SCOPUS ID: 2-s2.0-84866460526 04/28/2012       24 Citations
  • Editorial Comment to Renoprotective effect of erythropoietin in ischemia/reperfusion injury: possible roles of the Akt/endothelial nitric oxide synthase-dependent pathway. (Regner KR) Int J Urol 2012 Mar;19(3):256 PMID: 22151694 SCOPUS ID: 2-s2.0-84857361563 12/14/2011    
  • Dual role of microsomal prostaglandin E synthase 1 in chronic kidney disease. (Regner KR) Hypertension 2012 Jan;59(1):12-3 PMID: 22106400 SCOPUS ID: 2-s2.0-83655201134 11/23/2011       7 Citations
  • Role of medullary blood flow in the pathogenesis of renal ischemia-reperfusion injury. (Regner KR, Roman RJ) Curr Opin Nephrol Hypertens 2012 Jan;21(1):33-8 PMID: 22080855 PMCID: PMC3612396 SCOPUS ID: 2-s2.0-83055186460 11/15/2011       54 Citations
  • Loss of activator of G-protein signaling 3 impairs renal tubular regeneration following acute kidney injury in rodents. (Regner KR, Nozu K, Lanier SM, Blumer JB, Avner ED, Sweeney WE Jr, Park F) FASEB J 2011 Jun;25(6):1844-55 PMID: 21343176 PMCID: PMC3101034 SCOPUS ID: 2-s2.0-79957927714 02/24/2011       33 Citations
  • 20-HETE in acute kidney injury. (Roman RJ, Akbulut T, Park F, Regner KR) Kidney Int 2011 Jan;79(1):10-3 PMID: 21157458 PMCID: PMC3146060 SCOPUS ID: 2-s2.0-78650266984 12/16/2010       15 Citations
  • Protective effect of Lifor solution in experimental renal ischemia-reperfusion injury. (Regner KR, Nilakantan V, Ryan RP, Mortensen J, White SM, Shames BD, Roman RJ) J Surg Res 2010 Dec;164(2):e291-7 PMID: 20888590 PMCID: PMC2991539 SCOPUS ID: 2-s2.0-78449301861 10/05/2010       26 Citations
  • Cardiac myocyte-specific overexpression of human GTP cyclohydrolase I protects against acute cardiac allograft rejection. (Ionova IA, Vásquez-Vivar J, Cooley BC, Khanna AK, Whitsett J, Herrnreiter A, Migrino RQ, Ge ZD, Regner KR, Channon KM, Alp NJ, Pieper GM) Am J Physiol Heart Circ Physiol 2010 Jul;299(1):H88-96 PMID: 20418482 PMCID: PMC2904123 SCOPUS ID: 2-s2.0-77953745147 04/27/2010       6 Citations
  • Heterogeneous stock rats: a new model to study the genetics of renal phenotypes. (Solberg Woods LC, Stelloh C, Regner KR, Schwabe T, Eisenhauer J, Garrett MR) Am J Physiol Renal Physiol 2010 Jun;298(6):F1484-91 PMID: 20219828 PMCID: PMC2886820 SCOPUS ID: 2-s2.0-77952706580 03/12/2010       25 Citations
  • 20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism. (Akbulut T, Regner KR, Roman RJ, Avner ED, Falck JR, Park F) Am J Physiol Renal Physiol 2009 Sep;297(3):F662-70 PMID: 19570883 PMCID: PMC2739708 SCOPUS ID: 2-s2.0-69449101237 07/03/2009       44 Citations
  • MnTMPyP, a cell-permeant SOD mimetic, reduces oxidative stress and apoptosis following renal ischemia-reperfusion. (Liang HL, Hilton G, Mortensen J, Regner K, Johnson CP, Nilakantan V) Am J Physiol Renal Physiol 2009 Feb;296(2):F266-76 PMID: 19091787 PMCID: PMC2643863 SCOPUS ID: 2-s2.0-60549097415 12/19/2008       63 Citations
  • Protective effect of 20-HETE analogues in experimental renal ischemia reperfusion injury. (Regner KR, Zuk A, Van Why SK, Shames BD, Ryan RP, Falck JR, Manthati VL, McMullen ME, Ledbetter SR, Roman RJ) Kidney Int 2009 Mar;75(5):511-7 PMID: 19052533 PMCID: PMC2643317 SCOPUS ID: 2-s2.0-60749108287 12/05/2008       65 Citations
  • Obstructive renal failure from malpositioned urinary catheter. (El-Zoghby ZM, Regner KR, Regner DM, Haugen EN) Kidney Int 2008 Jun;73(11):1330 PMID: 18480860 SCOPUS ID: 2-s2.0-43749122123 05/16/2008       1 Citation
  • Epidemiology of acute kidney injury after cardiac surgery: An update (Regner KR) Journal of Organ Dysfunction 2007;3(4):232-239 SCOPUS ID: 2-s2.0-35848948866 11/14/2007       1 Citation
  • Acute renal failure after cardiac surgery for carcinoid heart disease: incidence, risk factors, and prognosis. (Regner KR, Connolly HM, Schaff HV, Albright RC) Am J Kidney Dis 2005 May;45(5):826-32 PMID: 15861347 SCOPUS ID: 2-s2.0-26944442077 04/30/2005       26 Citations
  • 35-year-old woman with cough, fever, and anorexia. (Ensminger SA, Regner KR, Froehling DA) Mayo Clin Proc 2003 Jun;78(6):753-6 PMID: 12934787 SCOPUS ID: 2-s2.0-0038726875 08/26/2003    
  • Serial measurement of serum tryptase in angiotensin-converting enzyme inhibitor-associated angioedema. (Regner KR, Riegert-Johnson DL, Volcheck GW) Mayo Clin Proc 2003 May;78(5):655-6 PMID: 12744557 SCOPUS ID: 2-s2.0-0038745593 05/15/2003       3 Citations
  • Angiotensin II blockade reduces radiation-induced proliferation in experimental radiation nephropathy. (Moulder JE, Fish BL, Regner KR, Cohen EP) Radiat Res 2002 Apr;157(4):393-401 PMID: 11893241 SCOPUS ID: 2-s2.0-0036210270 03/15/2002       23 Citations
  • Retinoic acid exacerbates experimental radiation nephropathy. (Moulder JE, Fish BL, Regner KR, Cohen EP, Raife TJ) Radiat Res 2002 Feb;157(2):199-203 PMID: 11835684 SCOPUS ID: 2-s2.0-0036152353 02/12/2002       20 Citations
  • Stenotic glomerulotubular necks in radiation nephropathy. (Cohen EP, Regner K, Fish BL, Moulder JE) J Pathol 2000 Mar;190(4):484-8 PMID: 10699999 SCOPUS ID: 2-s2.0-0034020686 03/04/2000       17 Citations
    • Last update: 04/11/2022