Medical College of Wisconsin
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Alison J. Kriegel PhD

Alison J. Kriegel PhD profile photo picture

Associate Professor

Institution: Medical College of Wisconsin
Department: Physiology

Member of the Cancer Center
Member of the Cardiovascular Center

Research Experience

  • Cardiovascular Physiological Phenomena
  • Cell Communication
  • Cell Physiological Phenomena
  • Paracrine Communication
  • MicroRNA
  • Molecular Biology
  • Physiological Genomics
  • Hypertension
  • Renal Physiology
  • Methodologies and Techniques

  • RNA analysis
  • Models of Renal Pathology
  • qRT-PCR
  • miRNA analysis
  • Rodent Left Ventricle Pressure-Volume Loop Analysis
  • Models of Cardiac Pathology
  • Next-generation RNA Sequencing
  • Rodent Echocardiography
  • Western Blot
  • Publications (31)

  • miR-146b-5p has a sex-specific role in renal and cardiac pathology in a rat model of chronic kidney disease. (Paterson MR, Geurts AM, Kriegel AJ) Kidney Int 2019 12;96(6):1332-1345 PMID: 31668631 PMCID: PMC6941490 SCOPUS ID: 2-s2.0-85074541202 11/02/2019       9 Citations
  • Dietary Effects on Dahl Salt-Sensitive Hypertension, Renal Damage, and the T Lymphocyte Transcriptome. (Abais-Battad JM, Alsheikh AJ, Pan X, Fehrenbach DJ, Dasinger JH, Lund H, Roberts ML, Kriegel AJ, Cowley AW Jr, Kidambi S, Kotchen TA, Liu P, Liang M, Mattson DL) Hypertension 2019 10;74(4):854-863 PMID: 31476910 PMCID: PMC6739138 SCOPUS ID: 2-s2.0-85072134357 09/04/2019       15 Citations
  • Detrimental effects of chemotherapy on human coronary microvascular function. (Hader SN, Zinkevich N, Norwood Toro LE, Kriegel AJ, Kong A, Freed JK, Gutterman DD, Beyer AM) Am J Physiol Heart Circ Physiol 2019 10 01;317(4):H705-H710 PMID: 31397169 PMCID: PMC6843017 SCOPUS ID: 2-s2.0-85072508643 08/10/2019       5 Citations
  • Adverse early-life environment impairs postnatal lung development in mice. (Lai PY, Jing X, Michalkiewicz T, Entringer B, Ke X, Majnik A, Kriegel AJ, Liu P, Lane RH, Konduri GG) Physiol Genomics 2019 09 01;51(9):462-470 PMID: 31373541 PMCID: PMC6766700 SCOPUS ID: 2-s2.0-85072265843 08/03/2019       3 Citations
  • Library Preparation for Multiplexed Reduced Representation Bisulfite Sequencing with a Universal Adapter. (Liu Y, Kriegel AJ, Liang M) Methods Mol Biol 2019;2018:177-194 PMID: 31228157 SCOPUS ID: 2-s2.0-85068180336 06/23/2019    
  • Salt-deficient diet exacerbates cystogenesis in ARPKD via epithelial sodium channel (ENaC). (Ilatovskaya DV, Levchenko V, Pavlov TS, Isaeva E, Klemens CA, Johnson J, Liu P, Kriegel AJ, Staruschenko A) EBioMedicine 2019 Feb;40:663-674 PMID: 30745171 PMCID: PMC6413684 SCOPUS ID: 2-s2.0-85061112508 02/13/2019       14 Citations
  • miR-21-5p regulates mitochondrial respiration and lipid content in H9C2 cells. (Nasci VL, Chuppa S, Griswold L, Goodreau KA, Dash RK, Kriegel AJ) Am J Physiol Heart Circ Physiol 2019 03 01;316(3):H710-H721 PMID: 30657727 PMCID: PMC6459316 SCOPUS ID: 2-s2.0-85062599405 01/19/2019       7 Citations
  • MiR-192-5p in the Kidney Protects Against the Development of Hypertension. (Baker MA, Wang F, Liu Y, Kriegel AJ, Geurts AM, Usa K, Xue H, Wang D, Kong Y, Liang M) Hypertension 2019 02;73(2):399-406 PMID: 30595117 PMCID: PMC6339564 SCOPUS ID: 2-s2.0-85059796489 01/01/2019       22 Citations
  • Isomer-specific effect of microRNA miR-29b on nuclear morphology. (Kriegel AJ, Terhune SS, Greene AS, Noon KR, Pereckas MS, Liang M) J Biol Chem 2018 09 07;293(36):14080-14088 PMID: 30006350 PMCID: PMC6130969 SCOPUS ID: 2-s2.0-85053013199 07/15/2018       8 Citations
  • α-Galactosidase A-deficient rats accumulate glycosphingolipids and develop cardiorenal phenotypes of Fabry disease. (Miller JJ, Aoki K, Mascari CA, Beltrame AK, Sokumbi O, North PE, Tiemeyer M, Kriegel AJ, Dahms NM) FASEB J 2019 01;33(1):418-429 PMID: 29979634 PMCID: PMC6629127 SCOPUS ID: 2-s2.0-85059237456 07/07/2018       9 Citations
  • miR-29 contributes to normal endothelial function and can restore it in cardiometabolic disorders. (Widlansky ME, Jensen DM, Wang J, Liu Y, Geurts AM, Kriegel AJ, Liu P, Ying R, Zhang G, Casati M, Chu C, Malik M, Branum A, Tanner MJ, Tyagi S, Usa K, Liang M) EMBO Mol Med 2018 03;10(3) PMID: 29374012 PMCID: PMC5840545 SCOPUS ID: 2-s2.0-85041063208 01/28/2018       43 Citations
  • MicroRNA-21 regulates peroxisome proliferator-activated receptor alpha, a molecular mechanism of cardiac pathology in Cardiorenal Syndrome Type 4. (Chuppa S, Liang M, Liu P, Liu Y, Casati MC, Cowley AW, Patullo L, Kriegel AJ) Kidney Int 2018 02;93(2):375-389 PMID: 28760335 PMCID: PMC5787401 SCOPUS ID: 2-s2.0-85026463717 08/02/2017       34 Citations
  • MiR-146a/b: a family with shared seeds and different roots. (Paterson MR, Kriegel AJ) Physiol Genomics 2017 Apr 01;49(4):243-252 PMID: 28213571 PMCID: PMC5407182 SCOPUS ID: 2-s2.0-85018520006 02/19/2017       55 Citations
  • Renal Delivery of Anti-microRNA Oligonucleotides in Rats. (Usa KS, Liu Y, Kurth T, Kriegel AJ, Mattson DL, Cowley AW Jr, Liang M) Methods Mol Biol 2017;1527:409-419 PMID: 28116733 SCOPUS ID: 2-s2.0-85011003449 01/25/2017    
  • Molecular Approaches in HFpEF: MicroRNAs and iPSC-Derived Cardiomyocytes. (Kriegel AJ, Gartz M, Afzal MZ, de Lange WJ, Ralphe JC, Strande JL) J Cardiovasc Transl Res 2017 Jun;10(3):295-304 PMID: 28032312 PMCID: PMC5937699 SCOPUS ID: 2-s2.0-85007413634 12/30/2016       6 Citations
  • Endogenous microRNAs in human microvascular endothelial cells regulate mRNAs encoded by hypertension-related genes. (Kriegel AJ, Baker MA, Liu Y, Liu P, Cowley AW Jr, Liang M) Hypertension 2015 Oct;66(4):793-9 PMID: 26283043 PMCID: PMC4567475 SCOPUS ID: 2-s2.0-84941199042 08/19/2015       65 Citations
  • Up-regulation of microRNA-21 mediates isoflurane-induced protection of cardiomyocytes. (Olson JM, Yan Y, Bai X, Ge ZD, Liang M, Kriegel AJ, Twaroski DM, Bosnjak ZJ) Anesthesiology 2015 Apr;122(4):795-805 PMID: 25536091 PMCID: PMC4366274 SCOPUS ID: 2-s2.0-84937250884 12/24/2014       35 Citations
  • miR-21 in ischemia/reperfusion injury: a double-edged sword? (Xu X, Kriegel AJ, Jiao X, Liu H, Bai X, Olson J, Liang M, Ding X) Physiol Genomics 2014 Nov 01;46(21):789-97 PMID: 25159851 PMCID: PMC4280148 SCOPUS ID: 2-s2.0-84908453071 08/28/2014       73 Citations
  • MicroRNA in situ hybridization for formalin fixed kidney tissues. (Kriegel AJ, Liang M) J Vis Exp 2013 Nov 30(81) PMID: 24326287 PMCID: PMC3992125 SCOPUS ID: 2-s2.0-84888876317 12/12/2013       11 Citations
  • Characteristics of microRNAs enriched in specific cell types and primary tissue types in solid organs. (Kriegel AJ, Liu Y, Liu P, Baker MA, Hodges MR, Hua X, Liang M) Physiol Genomics 2013 Dec 01;45(23):1144-56 PMID: 24085797 PMCID: PMC3882707 SCOPUS ID: 2-s2.0-84888802105 10/03/2013       23 Citations
  • Intermittent exposure to xenon protects against gentamicin-induced nephrotoxicity. (Jia P, Teng J, Zou J, Fang Y, Jiang S, Yu X, Kriegel AJ, Liang M, Ding X) PLoS One 2013;8(5):e64329 PMID: 23737979 PMCID: PMC3667819 SCOPUS ID: 2-s2.0-84878490659 06/06/2013       30 Citations
  • Hypoxic preconditioning with cobalt of bone marrow mesenchymal stem cells improves cell migration and enhances therapy for treatment of ischemic acute kidney injury. (Yu X, Lu C, Liu H, Rao S, Cai J, Liu S, Kriegel AJ, Greene AS, Liang M, Ding X) PLoS One 2013;8(5):e62703 PMID: 23671625 PMCID: PMC3650042 SCOPUS ID: 2-s2.0-84877330228 05/15/2013       64 Citations
  • miR-29c is downregulated in renal interstitial fibrosis in humans and rats and restored by HIF-α activation. (Fang Y, Yu X, Liu Y, Kriegel AJ, Heng Y, Xu X, Liang M, Ding X) Am J Physiol Renal Physiol 2013 May 15;304(10):F1274-82 PMID: 23467423 PMCID: PMC3651624 SCOPUS ID: 2-s2.0-84878641501 03/08/2013       83 Citations
  • Delayed ischemic preconditioning contributes to renal protection by upregulation of miR-21. (Xu X, Kriegel AJ, Liu Y, Usa K, Mladinov D, Liu H, Fang Y, Ding X, Liang M) Kidney Int 2012 Dec;82(11):1167-75 PMID: 22785173 PMCID: PMC3777822 SCOPUS ID: 2-s2.0-84869212341 07/13/2012       133 Citations
  • Mechanisms of cardioprotection resulting from Brown Norway chromosome 16 substitution in the salt-sensitive Dahl rat. (Kriegel AJ, Didier DN, Li P, Lazar J, Greene AS) Physiol Genomics 2012 Aug 17;44(16):819-27 PMID: 22759922 PMCID: PMC3774569 SCOPUS ID: 2-s2.0-84865817728 07/05/2012       4 Citations
  • Translational study of microRNAs and its application in kidney disease and hypertension research. (Kriegel AJ, Mladinov D, Liang M) Clin Sci (Lond) 2012 May 01;122(10):439-47 PMID: 22283365 PMCID: PMC4428581 SCOPUS ID: 2-s2.0-84858729145 01/31/2012       16 Citations
  • The miR-29 family: genomics, cell biology, and relevance to renal and cardiovascular injury. (Kriegel AJ, Liu Y, Fang Y, Ding X, Liang M) Physiol Genomics 2012 Feb 27;44(4):237-44 PMID: 22214600 PMCID: PMC3289120 SCOPUS ID: 2-s2.0-84863230332 01/05/2012       316 Citations
  • MiR-382 targeting of kallikrein 5 contributes to renal inner medullary interstitial fibrosis. (Kriegel AJ, Liu Y, Cohen B, Usa K, Liu Y, Liang M) Physiol Genomics 2012 Feb 27;44(4):259-67 PMID: 22202692 PMCID: PMC3289118 SCOPUS ID: 2-s2.0-84863229877 12/29/2011       60 Citations
  • MicroRNA-target pairs in human renal epithelial cells treated with transforming growth factor beta 1: a novel role of miR-382. (Kriegel AJ, Fang Y, Liu Y, Tian Z, Mladinov D, Matus IR, Ding X, Greene AS, Liang M) Nucleic Acids Res 2010 Dec;38(22):8338-47 PMID: 20716515 PMCID: PMC3001085 SCOPUS ID: 2-s2.0-78650470110 08/19/2010       92 Citations
  • Substitution of Brown Norway chromosome 16 preserves cardiac function with aging in a salt-sensitive Dahl consomic rat. (Kriegel AJ, Greene AS) Physiol Genomics 2008 Dec 12;36(1):35-42 PMID: 18940898 PMCID: PMC2604784 SCOPUS ID: 2-s2.0-57749092868 10/23/2008       11 Citations
  • Combined effects of low-dose spironolactone and captopril therapy in a rat model of genetic hypertrophic cardiomyopathy. (de Resende MM, Kriegel AJ, Greene AS) J Cardiovasc Pharmacol 2006 Dec;48(6):265-73 PMID: 17204904 SCOPUS ID: 2-s2.0-33846045553 01/06/2007       24 Citations
  • Last update: 04/01/2021