Medical College of Wisconsin
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Alison J. Kriegel PhD

Alison J. Kriegel PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Physiology

Member of the Cancer Center
Member of the Cardiovascular Center


Research Experience

  • Cardiovascular Physiology
  • Cell Communication
  • Cell Physiology
  • Paracrine Communication
  • MicroRNA
  • Molecular Biology
  • Physiological Genomics
  • Hypertension
  • Renal Physiology
  • Methodologies and Techniques

  • RNA analysis
  • Models of Renal Pathology
  • qRT-PCR
  • miRNA analysis
  • Rodent Left Ventricle Pressure-Volume Loop Analysis
  • Models of Cardiac Pathology
  • Next-generation RNA Sequencing
  • Rodent Echocardiography
  • Western Blot
  • Publications

  • Endogenous microRNAs in human microvascular endothelial cells regulate mRNAs encoded by hypertension-related genes. (Kriegel AJ, Baker MA, Liu Y, Liu P, Cowley AW Jr, Liang M) Hypertension 2015 Oct;66(4):793-9 PMID: 26283043 PMCID: PMC4567475 08/19/2015
  • Up-regulation of microRNA-21 mediates isoflurane-induced protection of cardiomyocytes. (Olson JM, Yan Y, Bai X, Ge ZD, Liang M, Kriegel AJ, Twaroski DM, Bosnjak ZJ) Anesthesiology 2015 Apr;122(4):795-805 PMID: 25536091 PMCID: PMC4366274 12/24/2014
  • miR-21 in ischemia/reperfusion injury: a double-edged sword? (Xu X, Kriegel AJ, Jiao X, Liu H, Bai X, Olson J, Liang M, Ding X) Physiol Genomics 2014 Nov 01;46(21):789-97 PMID: 25159851 PMCID: PMC4280148 08/28/2014
  • MicroRNA in situ hybridization for formalin fixed kidney tissues. (Kriegel AJ, Liang M) J Vis Exp 2013 Nov 30(81) PMID: 24326287 PMCID: PMC3992125 12/12/2013
  • Characteristics of microRNAs enriched in specific cell types and primary tissue types in solid organs. (Kriegel AJ, Liu Y, Liu P, Baker MA, Hodges MR, Hua X, Liang M) Physiol Genomics 2013 Dec 01;45(23):1144-56 PMID: 24085797 PMCID: PMC3882707 10/03/2013
  • Intermittent exposure to xenon protects against gentamicin-induced nephrotoxicity. (Jia P, Teng J, Zou J, Fang Y, Jiang S, Yu X, Kriegel AJ, Liang M, Ding X) PLoS One 2013;8(5):e64329 PMID: 23737979 PMCID: PMC3667819 06/06/2013
  • Hypoxic preconditioning with cobalt of bone marrow mesenchymal stem cells improves cell migration and enhances therapy for treatment of ischemic acute kidney injury. (Yu X, Lu C, Liu H, Rao S, Cai J, Liu S, Kriegel AJ, Greene AS, Liang M, Ding X) PLoS One 2013;8(5):e62703 PMID: 23671625 PMCID: PMC3650042 05/15/2013
  • miR-29c is downregulated in renal interstitial fibrosis in humans and rats and restored by HIF-α activation. (Fang Y, Yu X, Liu Y, Kriegel AJ, Heng Y, Xu X, Liang M, Ding X) Am J Physiol Renal Physiol 2013 May 15;304(10):F1274-82 PMID: 23467423 PMCID: PMC3651624 03/08/2013
  • Delayed ischemic preconditioning contributes to renal protection by upregulation of miR-21. (Xu X, Kriegel AJ, Liu Y, Usa K, Mladinov D, Liu H, Fang Y, Ding X, Liang M) Kidney Int 2012 Dec;82(11):1167-75 PMID: 22785173 PMCID: PMC3777822 07/13/2012
  • Mechanisms of cardioprotection resulting from Brown Norway chromosome 16 substitution in the salt-sensitive Dahl rat. (Kriegel AJ, Didier DN, Li P, Lazar J, Greene AS) Physiol Genomics 2012 Aug 17;44(16):819-27 PMID: 22759922 PMCID: PMC3774569 07/05/2012
  • Translational study of microRNAs and its application in kidney disease and hypertension research. (Kriegel AJ, Mladinov D, Liang M) Clin Sci (Lond) 2012 May 01;122(10):439-47 PMID: 22283365 PMCID: PMC4428581 01/31/2012
  • The miR-29 family: genomics, cell biology, and relevance to renal and cardiovascular injury. (Kriegel AJ, Liu Y, Fang Y, Ding X, Liang M) Physiol Genomics 2012 Feb 27;44(4):237-44 PMID: 22214600 PMCID: PMC3289120 01/05/2012
  • MiR-382 targeting of kallikrein 5 contributes to renal inner medullary interstitial fibrosis. (Kriegel AJ, Liu Y, Cohen B, Usa K, Liu Y, Liang M) Physiol Genomics 2012 Feb 27;44(4):259-67 PMID: 22202692 PMCID: PMC3289118 12/29/2011
  • MicroRNA-target pairs in human renal epithelial cells treated with transforming growth factor beta 1: a novel role of miR-382. (Kriegel AJ, Fang Y, Liu Y, Tian Z, Mladinov D, Matus IR, Ding X, Greene AS, Liang M) Nucleic Acids Res 2010 Dec;38(22):8338-47 PMID: 20716515 PMCID: PMC3001085 08/19/2010
  • Substitution of Brown Norway chromosome 16 preserves cardiac function with aging in a salt-sensitive Dahl consomic rat. (Kriegel AJ, Greene AS) Physiol Genomics 2008 Dec 12;36(1):35-42 PMID: 18940898 PMCID: PMC2604784 10/23/2008
  • Combined effects of low-dose spironolactone and captopril therapy in a rat model of genetic hypertrophic cardiomyopathy. (de Resende MM, Kriegel AJ, Greene AS) J Cardiovasc Pharmacol 2006 Dec;48(6):265-73 PMID: 17204904 01/06/2007
  • Last update: 06/21/2016
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