Medical College of Wisconsin
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Alison J. Kriegel PhD

Alison J. Kriegel PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Physiology

Member of the Cancer Center
Member of the Cardiovascular Center

Research Experience

  • Cardiovascular Physiological Phenomena
  • Cell Communication
  • Cell Physiological Phenomena
  • Paracrine Communication
  • MicroRNA
  • Molecular Biology
  • Physiological Genomics
  • Hypertension
  • Renal Physiology
  • Methodologies and Techniques

  • RNA analysis
  • Models of Renal Pathology
  • qRT-PCR
  • miRNA analysis
  • Rodent Left Ventricle Pressure-Volume Loop Analysis
  • Models of Cardiac Pathology
  • Next-generation RNA Sequencing
  • Rodent Echocardiography
  • Western Blot
  • Publications

  • Isomer-specific effect of microRNA miR-29b on nuclear morphology. (Kriegel AJ, Terhune SS, Greene AS, Noon KR, Pereckas MS, Liang M) J Biol Chem 2018 Sep 07;293(36):14080-14088 PMID: 30006350 PMCID: PMC6130969 07/15/2018    
  • α-Galactosidase A-deficient rats accumulate glycosphingolipids and develop cardiorenal phenotypes of Fabry disease. (Miller JJ, Aoki K, Mascari CA, Beltrame AK, Sokumbi O, North PE, Tiemeyer M, Kriegel AJ, Dahms NM) FASEB J 2019 Jan;33(1):418-429 PMID: 29979634 07/07/2018    
  • miR-29 contributes to normal endothelial function and can restore it in cardiometabolic disorders. (Widlansky ME, Jensen DM, Wang J, Liu Y, Geurts AM, Kriegel AJ, Liu P, Ying R, Zhang G, Casati M, Chu C, Malik M, Branum A, Tanner MJ, Tyagi S, Usa K, Liang M) EMBO Mol Med 2018 03;10(3) PMID: 29374012 PMCID: PMC5840545 01/28/2018       7 Citations
  • MicroRNA-21 regulates peroxisome proliferator-activated receptor alpha, a molecular mechanism of cardiac pathology in Cardiorenal Syndrome Type 4. (Chuppa S, Liang M, Liu P, Liu Y, Casati MC, Cowley AW, Patullo L, Kriegel AJ) Kidney Int 2018 02;93(2):375-389 PMID: 28760335 PMCID: PMC5787401 08/02/2017       3 Citations
  • MiR-146a/b: a family with shared seeds and different roots. (Paterson MR, Kriegel AJ) Physiol Genomics 2017 Apr 01;49(4):243-252 PMID: 28213571 PMCID: PMC5407182 02/19/2017       8 Citations
  • Renal Delivery of Anti-microRNA Oligonucleotides in Rats. (Usa KS, Liu Y, Kurth T, Kriegel AJ, Mattson DL, Cowley AW Jr, Liang M) Methods Mol Biol 2017;1527:409-419 PMID: 28116733 01/25/2017    
  • Molecular Approaches in HFpEF: MicroRNAs and iPSC-Derived Cardiomyocytes. (Kriegel AJ, Gartz M, Afzal MZ, de Lange WJ, Ralphe JC, Strande JL) J Cardiovasc Transl Res 2017 Jun;10(3):295-304 PMID: 28032312 PMCID: PMC5937699 12/30/2016       3 Citations
  • Endogenous microRNAs in human microvascular endothelial cells regulate mRNAs encoded by hypertension-related genes. (Kriegel AJ, Baker MA, Liu Y, Liu P, Cowley AW Jr, Liang M) Hypertension 2015 Oct;66(4):793-9 PMID: 26283043 PMCID: PMC4567475 08/19/2015       32 Citations
  • Up-regulation of microRNA-21 mediates isoflurane-induced protection of cardiomyocytes. (Olson JM, Yan Y, Bai X, Ge ZD, Liang M, Kriegel AJ, Twaroski DM, Bosnjak ZJ) Anesthesiology 2015 Apr;122(4):795-805 PMID: 25536091 PMCID: PMC4366274 12/24/2014       18 Citations
  • miR-21 in ischemia/reperfusion injury: a double-edged sword? (Xu X, Kriegel AJ, Jiao X, Liu H, Bai X, Olson J, Liang M, Ding X) Physiol Genomics 2014 Nov 01;46(21):789-97 PMID: 25159851 PMCID: PMC4280148 08/28/2014       37 Citations
  • MicroRNA in situ hybridization for formalin fixed kidney tissues. (Kriegel AJ, Liang M) J Vis Exp 2013 Nov 30(81) PMID: 24326287 PMCID: PMC3992125 12/12/2013       5 Citations
  • Characteristics of microRNAs enriched in specific cell types and primary tissue types in solid organs. (Kriegel AJ, Liu Y, Liu P, Baker MA, Hodges MR, Hua X, Liang M) Physiol Genomics 2013 Dec 01;45(23):1144-56 PMID: 24085797 PMCID: PMC3882707 10/03/2013       14 Citations
  • Intermittent exposure to xenon protects against gentamicin-induced nephrotoxicity. (Jia P, Teng J, Zou J, Fang Y, Jiang S, Yu X, Kriegel AJ, Liang M, Ding X) PLoS One 2013;8(5):e64329 PMID: 23737979 PMCID: PMC3667819 06/06/2013       24 Citations
  • Hypoxic preconditioning with cobalt of bone marrow mesenchymal stem cells improves cell migration and enhances therapy for treatment of ischemic acute kidney injury. (Yu X, Lu C, Liu H, Rao S, Cai J, Liu S, Kriegel AJ, Greene AS, Liang M, Ding X) PLoS One 2013;8(5):e62703 PMID: 23671625 PMCID: PMC3650042 05/15/2013       50 Citations
  • miR-29c is downregulated in renal interstitial fibrosis in humans and rats and restored by HIF-α activation. (Fang Y, Yu X, Liu Y, Kriegel AJ, Heng Y, Xu X, Liang M, Ding X) Am J Physiol Renal Physiol 2013 May 15;304(10):F1274-82 PMID: 23467423 PMCID: PMC3651624 03/08/2013       60 Citations
  • Delayed ischemic preconditioning contributes to renal protection by upregulation of miR-21. (Xu X, Kriegel AJ, Liu Y, Usa K, Mladinov D, Liu H, Fang Y, Ding X, Liang M) Kidney Int 2012 Dec;82(11):1167-75 PMID: 22785173 PMCID: PMC3777822 07/13/2012       94 Citations
  • Mechanisms of cardioprotection resulting from Brown Norway chromosome 16 substitution in the salt-sensitive Dahl rat. (Kriegel AJ, Didier DN, Li P, Lazar J, Greene AS) Physiol Genomics 2012 Aug 17;44(16):819-27 PMID: 22759922 PMCID: PMC3774569 07/05/2012       4 Citations
  • Translational study of microRNAs and its application in kidney disease and hypertension research. (Kriegel AJ, Mladinov D, Liang M) Clin Sci (Lond) 2012 May 01;122(10):439-47 PMID: 22283365 PMCID: PMC4428581 01/31/2012       12 Citations
  • The miR-29 family: genomics, cell biology, and relevance to renal and cardiovascular injury. (Kriegel AJ, Liu Y, Fang Y, Ding X, Liang M) Physiol Genomics 2012 Feb 27;44(4):237-44 PMID: 22214600 PMCID: PMC3289120 01/05/2012       195 Citations
  • MiR-382 targeting of kallikrein 5 contributes to renal inner medullary interstitial fibrosis. (Kriegel AJ, Liu Y, Cohen B, Usa K, Liu Y, Liang M) Physiol Genomics 2012 Feb 27;44(4):259-67 PMID: 22202692 PMCID: PMC3289118 12/29/2011       50 Citations
  • MicroRNA-target pairs in human renal epithelial cells treated with transforming growth factor beta 1: a novel role of miR-382. (Kriegel AJ, Fang Y, Liu Y, Tian Z, Mladinov D, Matus IR, Ding X, Greene AS, Liang M) Nucleic Acids Res 2010 Dec;38(22):8338-47 PMID: 20716515 PMCID: PMC3001085 08/19/2010       77 Citations
  • Substitution of Brown Norway chromosome 16 preserves cardiac function with aging in a salt-sensitive Dahl consomic rat. (Kriegel AJ, Greene AS) Physiol Genomics 2008 Dec 12;36(1):35-42 PMID: 18940898 PMCID: PMC2604784 10/23/2008       10 Citations
  • Combined effects of low-dose spironolactone and captopril therapy in a rat model of genetic hypertrophic cardiomyopathy. (de Resende MM, Kriegel AJ, Greene AS) J Cardiovasc Pharmacol 2006 Dec;48(6):265-73 PMID: 17204904 01/06/2007       21 Citations
  • Last update: 06/21/2016
    jenkins-FCD Prod-299 9ef562391eceb2b8f95265c767fbba1ce5a52fd6