Medical College of Wisconsin
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Dev Karan PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Pathology
Division: Administration

Member of the Cancer Center
Member of the Center for Immunology

Publications (66)

  • Manzamine A reduces androgen receptor transcription and synthesis by blocking E2F8-DNA interactions and effectively inhibits prostate tumor growth in mice. (Karan D, Dubey S, Gunewardena S, Iczkowski KA, Singh M, Liu P, Poletti A, Choo YM, Chen HZ, Hamann MT) Mol Oncol 2024 Aug;18(8):1966-1979 PMID: 38605607 PMCID: PMC11306517 SCOPUS ID: 2-s2.0-85190504464 04/12/2024    
  • Reply to "Contextualizing racial associations in prostate cancer to expose structural causes". (Karan D, Wick J, Dubey S, Kumar-Sinha C, Siddiqui J, Kunju LP, Iczkowski KA, Chinnaiyan AM) Cancer 2024 Feb 15;130(4):647-648 PMID: 38079361 PMCID: PMC10922162 SCOPUS ID: 2-s2.0-85179300225 12/11/2023    
  • Racial differences in serum chemokines in prostate cancer patients. (Karan D, Wick J, Dubey S, Kumar-Sinha C, Siddiqui J, Kunju LP, Iczkowski KA, Chinnaiyan AM) Cancer 2023 Dec 01;129(23):3783-3789 PMID: 37698493 SCOPUS ID: 2-s2.0-85170696897 09/12/2023       3 Citations
  • DNA Methyltransferase 1 Targeting Using Guadecitabine Inhibits Prostate Cancer Growth by an Apoptosis-Independent Pathway. (Karan D, Singh M, Dubey S, Van Veldhuizen PJ, Saunthararajah Y) Cancers (Basel) 2023 May 15;15(10) PMID: 37345101 PMCID: PMC10216613 SCOPUS ID: 2-s2.0-85160763012 06/22/2023       1 Citation
  • DNA Methyltransferase 1 Targeting Using Guadecitabine Inhibits Prostate Cancer Growth by an Apoptosis-Independent Pathway (Karan D, Singh M, Dubey S, Van Veldhuizen PJ, Saunthararajah Y) Cancers May 2023;15(10) SCOPUS ID: 2-s2.0-85160763012 05/01/2023       1 Citation
  • CCL23 in Balancing the Act of Endoplasmic Reticulum Stress and Antitumor Immunity in Hepatocellular Carcinoma. (Karan D) Front Oncol 2021;11:727583 PMID: 34671553 PMCID: PMC8522494 SCOPUS ID: 2-s2.0-85117317725 10/22/2021       5 Citations
  • CCL23 in Balancing the Act of Endoplasmic Reticulum Stress and Antitumor Immunity in Hepatocellular Carcinoma (Karan D) Frontiers in Oncology 4 October 2021;11 SCOPUS ID: 2-s2.0-85117317725 10/04/2021       5 Citations
  • RSK1 vs. RSK2 Inhibitory Activity of the Marine β-Carboline Alkaloid Manzamine A: A Biochemical, Cervical Cancer Protein Expression, and Computational Study. (Mayer AMS, Hall ML, Lach J, Clifford J, Chandrasena K, Canton C, Kontoyianni M, Choo YM, Karan D, Hamann MT) Mar Drugs 2021 Sep 07;19(9) PMID: 34564169 PMCID: PMC8467814 SCOPUS ID: 2-s2.0-85114615152 09/27/2021       8 Citations
  • A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer. (Dubey S, Singh M, Nelson A, Karan D) J Immunol Res 2021;2021:9483433 PMID: 34485538 PMCID: PMC8413038 SCOPUS ID: 2-s2.0-85114595038 09/07/2021       7 Citations
  • RSK1 vs. RSK2 Inhibitory Activity of the Marine β-Carboline Alkaloid Manzamine A: A Biochemical, Cervical Cancer Protein Expression, and Computational Study 09/07/2021    
  • RSK1 vs. RSK2 inhibitory activity of the marine β-carboline alkaloid manzamine A: A biochemical, cervical cancer protein expression, and computational study (Mayer AMS, Hall ML, Lach J, Clifford J, Chandrasena K, Canton C, Kontoyianni M, Choo YM, Karan D, Hamann MT) Marine Drugs September 2021;19(9) SCOPUS ID: 2-s2.0-85114615152 09/01/2021       8 Citations
  • Circulatory MIC-1 as a Determinant of Prostate Cancer Racial Disparity. (Karan D, Wick J, Dubey S, Tawfik O, Van Veldhuizen P) Cancers (Basel) 2020 Oct 18;12(10) PMID: 33081054 PMCID: PMC7603134 SCOPUS ID: 2-s2.0-85092730865 10/22/2020       3 Citations
  • The Marine Natural Product Manzamine A Inhibits Cervical Cancer by Targeting the SIX1 Protein. (Karan D, Dubey S, Pirisi L, Nagel A, Pina I, Choo YM, Hamann MT) J Nat Prod 2020 Feb 28;83(2):286-295 PMID: 32022559 PMCID: PMC7161578 SCOPUS ID: 2-s2.0-85079554428 02/06/2020       34 Citations
  • Inflammasomes: Emerging Central Players in Cancer Immunology and Immunotherapy. (Karan D) Front Immunol 2018;9:3028 PMID: 30631327 PMCID: PMC6315184 SCOPUS ID: 2-s2.0-85059829126 01/12/2019       38 Citations
  • Withaferin A Associated Differential Regulation of Inflammatory Cytokines. (Dubey S, Yoon H, Cohen MS, Nagarkatti P, Nagarkatti M, Karan D) Front Immunol 2018;9:195 PMID: 29479354 PMCID: PMC5811468 SCOPUS ID: 2-s2.0-85041817461 02/27/2018       35 Citations
  • Formulation of the bivalent prostate cancer vaccine with surgifoam elicits antigen-specific effector T cells in PSA-transgenic mice. (Karan D) Vaccine 2017 Oct 13;35(43):5794-5798 PMID: 28939158 PMCID: PMC5617798 SCOPUS ID: 2-s2.0-85029555973 09/25/2017       8 Citations
  • Expression analysis of inflammasome sensors and implication of NLRP12 inflammasome in prostate cancer. (Karan D, Tawfik O, Dubey S) Sci Rep 2017 Jun 29;7(1):4378 PMID: 28663562 PMCID: PMC5491527 SCOPUS ID: 2-s2.0-85021638100 07/01/2017       43 Citations
  • From Inflammation to Prostate Cancer: The Role of Inflammasomes. (Karan D, Dubey S) Adv Urol 2016;2016:3140372 PMID: 27429614 PMCID: PMC4939357 SCOPUS ID: 2-s2.0-84982845403 07/19/2016       49 Citations
  • Prostate immunotherapy: should all guns be aimed at the prostate-specific antigen? (Karan D) Immunotherapy 2013 Sep;5(9):907-10 PMID: 23998723 PMCID: PMC5242386 SCOPUS ID: 2-s2.0-84883564686 09/04/2013       6 Citations
  • Combination immunotherapy with prostate GVAX and ipilimumab: safety and toxicity. (Karan D, Van Veldhuizen P) Immunotherapy 2012 Jun;4(6):577-80 PMID: 22788125 SCOPUS ID: 2-s2.0-84863914828 07/14/2012       14 Citations
  • Inflammation-associated regulation of the macrophage inhibitory cytokine (MIC-1) gene in prostate cancer. (Dubey S, Vanveldhuizen P, Holzbeierlein J, Tawfik O, Thrasher JB, Karan D) Oncol Lett 2012 May;3(5):1166-1170 PMID: 22783412 PMCID: PMC3389684 SCOPUS ID: 2-s2.0-84857944000 07/12/2012       12 Citations
  • Cancer immunotherapy: a paradigm shift for prostate cancer treatment. (Karan D, Holzbeierlein JM, Van Veldhuizen P, Thrasher JB) Nat Rev Urol 2012 May 29;9(7):376-85 PMID: 22641164 SCOPUS ID: 2-s2.0-84863718973 05/30/2012       32 Citations
  • Prostate cancer immunotherapy (Karan D, Van Veldhuizen P) Current Cancer Therapy Reviews 2012;8(4):237 SCOPUS ID: 2-s2.0-84874896434 01/01/2012    
  • Adenovirus-based immunotherapy for prostate cancer (Dubey S, Van Veldhuizen P, Karan D) Current Cancer Therapy Reviews 2012;8(4):264-270 SCOPUS ID: 2-s2.0-84874854857 01/01/2012       1 Citation
  • Prostate cancer immunotherapy: An evolving field (Hashmi M, Karan D, Phadke S, Saunthararajah Y, Kambhampati S, Van Veldhuizen P) Current Cancer Therapy Reviews 2012;8(4):274-282 SCOPUS ID: 2-s2.0-84874842943 01/01/2012    
  • Dual antigen target-based immunotherapy for prostate cancer eliminates the growth of established tumors in mice. (Karan D, Dubey S, Van Veldhuizen P, Holzbeierlein JM, Tawfik O, Thrasher JB) Immunotherapy 2011 Jun;3(6):735-46 PMID: 21668311 SCOPUS ID: 2-s2.0-79959193683 06/15/2011       20 Citations
  • CpG oligonucleotide as an adjuvant for the treatment of prostate cancer. (Lubaroff DM, Karan D) Adv Drug Deliv Rev 2009 Mar 28;61(3):268-74 PMID: 19166887 SCOPUS ID: 2-s2.0-61849089867 01/27/2009       20 Citations
  • Macrophage inhibitory cytokine-1: possible bridge molecule of inflammation and prostate cancer. (Karan D, Holzbeierlein J, Thrasher JB) Cancer Res 2009 Jan 01;69(1):2-5 PMID: 19117979 SCOPUS ID: 2-s2.0-58249112143 01/02/2009       56 Citations
  • Prostate cancer: genes, environment, immunity and the use of immunotherapy. (Karan D, Thrasher JB, Lubaroff D) Prostate Cancer Prostatic Dis 2008;11(3):230-6 PMID: 18283297 SCOPUS ID: 2-s2.0-50649089095 02/20/2008       26 Citations
  • Paradoxical enhancement of CD8 T cell-dependent anti-tumor protection despite reduced CD8 T cell responses with addition of a TLR9 agonist to a tumor vaccine. (Karan D, Krieg AM, Lubaroff DM) Int J Cancer 2007 Oct 01;121(7):1520-8 PMID: 17565748 SCOPUS ID: 2-s2.0-34548284487 06/15/2007       41 Citations
  • Prostate-derived factor as a paracrine and autocrine factor for the proliferation of androgen receptor-positive human prostate cancer cells. (Chen SJ, Karan D, Johansson SL, Lin FF, Zeckser J, Singh AP, Batra SK, Lin MF) Prostate 2007 Apr 01;67(5):557-71 PMID: 17221842 SCOPUS ID: 2-s2.0-34047209514 01/16/2007       64 Citations
  • Decreased cytotoxic T cell activity generated by co-administration of PSA vaccine and CpG ODN is associated with increased tumor protection in a mouse model of prostate cancer. (Lubaroff DM, Karan D, Andrews MP, Acosta A, Abouassaly C, Sharma M, Krieg AM) Vaccine 2006 Aug 28;24(35-36):6155-62 PMID: 16876291 SCOPUS ID: 2-s2.0-33746978211 08/01/2006       29 Citations
  • Androgen deprivation induces human prostate epithelial neuroendocrine differentiation of androgen-sensitive LNCaP cells. (Yuan TC, Veeramani S, Lin FF, Kondrikou D, Zelivianski S, Igawa T, Karan D, Batra SK, Lin MF) Endocr Relat Cancer 2006 Mar;13(1):151-67 PMID: 16601285 SCOPUS ID: 2-s2.0-33645971015 04/08/2006       126 Citations
  • Evolution of the AMP-forming acetyl-CoA synthetase gene in the Drosophilidae family. (Karan D, Lesbats M, David JR, Capy P) J Mol Evol 2003;57 Suppl 1:S297-303 PMID: 15008428 SCOPUS ID: 2-s2.0-0348011471 03/11/2004       4 Citations
  • Expression of ADAMs (a disintegrin and metalloproteases) and TIMP-3 (tissue inhibitor of metalloproteinase-3) in human prostatic adenocarcinomas. (Karan D, Lin FC, Bryan M, Ringel J, Moniaux N, Lin MF, Batra SK) Int J Oncol 2003 Nov;23(5):1365-71 PMID: 14532978 SCOPUS ID: 2-s2.0-3142779503 10/09/2003       76 Citations
  • Dysregulated expression of MIC-1/PDF in human prostate tumor cells. (Karan D, Chen SJ, Johansson SL, Singh AP, Paralkar VM, Lin MF, Batra SK) Biochem Biophys Res Commun 2003 Jun 06;305(3):598-604 PMID: 12763036 SCOPUS ID: 2-s2.0-0038578603 05/24/2003       61 Citations
  • Current status of the molecular genetics of human prostatic adenocarcinomas. (Karan D, Lin MF, Johansson SL, Batra SK) Int J Cancer 2003 Jan 20;103(3):285-93 PMID: 12471610 SCOPUS ID: 2-s2.0-0037454778 12/10/2002       68 Citations
  • Expression profile of differentially-regulated genes during progression of androgen-independent growth in human prostate cancer cells. (Karan D, Kelly DL, Rizzino A, Lin MF, Batra SK) Carcinogenesis 2002 Jun;23(6):967-75 PMID: 12082018 SCOPUS ID: 2-s2.0-0036317452 06/26/2002       128 Citations
  • Establishment and characterization of androgen-independent human prostate cancer LNCaP cell model. (Igawa T, Lin FF, Lee MS, Karan D, Batra SK, Lin MF) Prostate 2002 Mar 01;50(4):222-35 PMID: 11870800 SCOPUS ID: 2-s2.0-0036187849 03/01/2002       165 Citations
  • Decreased androgen-responsive growth of human prostate cancer is associated with increased genetic alterations. (Karan D, Schmied BM, Dave BJ, Wittel UA, Lin MF, Batra SK) Clin Cancer Res 2001 Nov;7(11):3472-80 PMID: 11705865 SCOPUS ID: 2-s2.0-0035175919 11/14/2001       34 Citations
  • Mucins in protozoan parasites. (Jain M, Karan D, Batra SK, Varshney GC) Front Biosci 2001 Oct 01;6:D1276-83 PMID: 11578964 SCOPUS ID: 2-s2.0-0035486868 10/02/2001       6 Citations
  • Expression of tumor-associated glycoprotein-72 (TAG-72) antigen in human prostatic adenocarcinomas. (Karan D, Johansson SL, Lin MF, Batra SK) Oncol Rep 2001;8(5):1123-6 PMID: 11496328 SCOPUS ID: 2-s2.0-0035458868 08/10/2001       6 Citations
  • Chill-coma tolerance, a major climatic adaptation among Drosophila species. (Gibert P, Moreteau B, Pétavy G, Karan D, David JR) Evolution 2001 May;55(5):1063-8 PMID: 11430643 SCOPUS ID: 2-s2.0-0034977946 06/30/2001       198 Citations
  • Molecular evolution of the AMP-forming Acetyl-CoA synthetase. (Karan D, David JR, Capy P) Gene 2001 Mar 07;265(1-2):95-101 PMID: 11255012 SCOPUS ID: 2-s2.0-0035819933 03/20/2001       25 Citations
  • Geographical clines for quantitative traits in natural populations of a tropical drosophilid: Zaprionus indianus. (Karan D, Dubey S, Moreteau B, Parkash R, David JR) Genetica 2000;108(1):91-100 PMID: 11145427 SCOPUS ID: 2-s2.0-0034529450 01/06/2001       61 Citations
  • Cold tolerance in Drosophila: Adaptive variations revealed by the analysis of starvation survival reaction norms (Karan D, David JR) Journal of Thermal Biology 1 October 2000;25(5):345-351 SCOPUS ID: 2-s2.0-0033936801 10/01/2000       13 Citations
  • The genetics of phenotypic plasticity. IX. Genetic architecture, temperature, and sex differences in Drosophila melanogaster. (Karan D, Morin JP, Gibert P, Moreteau B, Scheiner SM, David JR) Evolution 2000 Jun;54(3):1035-40 PMID: 10937276 SCOPUS ID: 2-s2.0-0033926306 08/11/2000       25 Citations
  • Cold tolerance in Drosophila: adaptive variations revealed by the analysis of starvation survival reaction norms. (Karan D, David JR) J Therm Biol 2000 Oct 01;25(5):345-351 PMID: 10838173 06/06/2000    
  • Microspatial genetic differentiation for tolerance and utilization of various alcohols and acetic acid in Drosophila species from India. (Karan D, Parkash R, David JR) Genetica 1999;105(3):249-58 PMID: 10761109 SCOPUS ID: 2-s2.0-0033503473 04/13/2000       9 Citations
  • Growth temperature and reaction norms of morphometrical traits in a tropical drosophilid: Zaprionus indianus. (Karan D, Moreteau B, David JR) Heredity (Edinb) 1999 Oct;83 ( Pt 4):398-407 PMID: 10583541 SCOPUS ID: 2-s2.0-0032755816 12/03/1999       43 Citations
  • Body size reaction norms in Drosophila melanogaster: Temporal stability and genetic architecture in a natural population (Karan D, Morin JP, Gravot E, Moreteau B, David JR) Genetics Selection Evolution September/December 1999;31(5-6):491-508 SCOPUS ID: 2-s2.0-0033507771 01/01/1999       43 Citations
  • Phenotypic variability of quantitative traits in Indian populations of Drosophila kikkawai (Parkash R, Karan D, Kataria SK, Munjal AK) Journal of Zoological Systematics and Evolutionary Research March 1999;37(1):13-18 SCOPUS ID: 2-s2.0-0038604475 01/01/1999       6 Citations
  • Geographical variation in Adh(F) and alcoholic resource utilization in Indian populations of Drosophila melanogaster (Parkash R, Karan D, Munjal AK) Biological Journal of the Linnean Society February 1999;66(2):205-214 SCOPUS ID: 2-s2.0-0033032424 01/01/1999       11 Citations
  • Desiccation tolerance and starvation resistance exhibit opposite latitudinal clines in Indian geographical populations of Drosophila kikkawai (Karan D, Parkash R) Ecological Entomology November 1998;23(4):391-396 SCOPUS ID: 2-s2.0-0031733453 11/01/1998       45 Citations
  • Geographical divergence for quantitative traits in colonising populations of Drosophila kikkawai from India. (Parkash R, Karan D, Munjal AK) Hereditas 1998;128(3):201-5 PMID: 9760869 SCOPUS ID: 2-s2.0-0031666942 10/07/1998       6 Citations
  • Body size and developmental temperature in Drosophila melanogaster: Analysis of body weight reaction form (Karan D, Morin JP, Moreteau B, David JR) Journal of Thermal Biology October 1998;23(5):301-309 SCOPUS ID: 2-s2.0-0032190865 10/01/1998       47 Citations
  • Cold stress tolerance in Drosophila: Analysis of chill coma recovery in D. Melanogaster (Jean David R, Gibert P, Pla E, Petavy G, Karan D, Moreteau B) Journal of Thermal Biology October 1998;23(5):291-299 SCOPUS ID: 2-s2.0-0032190875 10/01/1998       166 Citations
  • Thermal adaptive significance of ADH and EST-6 allozymes in Indian geographical populations of Drosophila melanogaster Journal of Zoological Systematics and Evolutionary Research September 1998;36(3):147-152 09/01/1998    
  • Latitudinal clines for morphometrical traits in Drosophila kikkawai: a study of natural populations from the Indian subcontinent. (Karan D, Munjal AK, Gibert P, Moreteau B, Parkash R, David JR) Genet Res 1998 Feb;71(1):31-8 PMID: 9674381 SCOPUS ID: 2-s2.0-0031833504 07/23/1998       46 Citations
  • DESICCATION AND STARVATION TOLERANCE OF ADULT DROSOPHILA: OPPOSITE LATITUDINAL CLINES IN NATURAL POPULATIONS OF THREE DIFFERENT SPECIES. (Karan D, Dahiya N, Munjal AK, Gibert P, Moreteau B, Parkash R, David JR) Evolution 1998 Jun;52(3):825-831 PMID: 28565258 SCOPUS ID: 2-s2.0-0031817830 06/01/1998       117 Citations
  • Thermal adaptive significance of ADH and EST-6 allozymes in Indian geographical populations of Drosophila melanogaster (Parkash R, Munjal AK, Karan D) Journal of Zoological Systematics and Evolutionary Research September 1998;36(3):147-152 SCOPUS ID: 2-s2.0-1842812727 01/01/1998       1 Citation
  • Desiccation and starvation tolerance of adult Drosophila: Opposite latitudinal clines in natural populations of three different species (Karan D, Dahiya N, Munjal AK, Gibert P, Moreteau B, Parkash R, David JR) Evolution 1998;52(3):825-831 SCOPUS ID: 2-s2.0-0031817830 01/01/1998       117 Citations
  • Phenotypic plasticity and developmental temperature in drosophila: Analysis and significance of reaction norms of morphometrical traits (David JR, Gibert P, Gravot E, Petavy G, Morin JP, Karan D, Moreteau B) Journal of Thermal Biology December 1997;22(6):441-451 SCOPUS ID: 2-s2.0-0031461971 12/01/1997       99 Citations
  • Phenotypic plasticity and developmental temperature in drosophila: Analysis and significance of reaction norms of morphometrical traits Journal of Thermal Biology December 1997;22(6):441-451 12/01/1997    
  • Resource utilization in D. Ananassae populations (Karan D, Munjal AK, Prakash R) Journal of Advanced Zoology June 1997;18(1):18-22 SCOPUS ID: 2-s2.0-3042959989 06/01/1997    
  • Thoracic trident pigmentation in Drosophila melanogaster: Latitudinal and altitudinal clines in Indian populations (Munjal AK, Karan D, Gibert P, Moreteau B, Parkash R, David JR) Genetics Selection Evolution 1997;29(6):601-610 SCOPUS ID: 2-s2.0-0031416589 01/01/1997       59 Citations
    • Last update: 08/12/2024