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Dorothee Weihrauch DVM, PhD

Research Scientist II

Institution: Medical College of Wisconsin
Department: Anesthesiology
Division: Research

Member of the Cardiovascular Center

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Publications (99)

Red light mediates the exocytosis of vasodilatory vesicles from cultured endothelial cells: a cellular, and ex vivo murine model. (Weihrauch D, Keszler A, Broeckel G, Aranda E, Lindemer B, Lohr NL) Photochem Photobiol Sci 2024 Feb;23(2):355-364 PMID: 38277065 PMCID: PMC10917865 SCOPUS ID: 2-s2.0-85183148947 01/26/2024

Targeted muscle reinnervation prevents and reverses rat pain behaviors after nerve transection. (Roth E, Linehan A, Weihrauch D, Stucky C, Hogan Q, Hoben G) Pain 2023 Feb 01;164(2):316-324 PMID: 35639439 SCOPUS ID: 2-s2.0-85143752837 06/01/2022 5 Citations

In Vivo Characterization of a Red Light-Activated Vasodilation: A Photobiomodulation Study. (Keszler A, Lindemer B, Broeckel G, Weihrauch D, Gao Y, Lohr NL) Front Physiol 2022;13:880158 PMID: 35586710 PMCID: PMC9108481 SCOPUS ID: 2-s2.0-85130240732 05/20/2022 4 Citations

Red Light Mitigates the Deteriorating Placental Extracellular Matrix in Late Onset of Preeclampsia and Improves the Trophoblast Behavior. (Griffin J, Krolikowski JG, Kounga K, Struve J, Keszler A, Lindemer B, Bordas M, Broeckel G, Lohr NL, Weihrauch D) J Pregnancy 2022;2022:3922368 PMID: 35494491 PMCID: PMC9045993 SCOPUS ID: 2-s2.0-85129568653 05/03/2022

Non-thermal Infrared Light Treatment of Ischemia/Reperfusion Injury and Subsequent Analysis of Macrophage Differentiation. (Compton T, Poellinger N, Struve J, Krolikowski JG, Ninomiya JT, Weihrauch D) J Vis Exp 2021 Dec 30(178) PMID: 35037662 SCOPUS ID: 2-s2.0-85123654791 01/18/2022 3 Citations

Electromagnetic energy (670 nm) stimulates vasodilation through activation of the large conductance potassium channel (BKCa). (Gebremendhin D, Lindemer B, Weihrauch D, Harder DR, Lohr NL) PLoS One 2021;16(10):e0257896 PMID: 34610026 PMCID: PMC8491904 SCOPUS ID: 2-s2.0-85116591248 10/06/2021 1 Citation

Red light stimulates vasodilation through extracellular vesicle trafficking. (Weihrauch D, Keszler A, Lindemer B, Krolikowski J, Lohr NL) J Photochem Photobiol B 2021 Jul;220:112212 PMID: 34049180 PMCID: PMC8240139 SCOPUS ID: 2-s2.0-85107807187 05/29/2021 13 Citations

Adjuvant doxycycline to enhance anti-amyloid effects: Results from the dual phase 2 trial. (D'Souza A, Szabo A, Flynn KE, Dhakal B, Chhabra S, Pasquini MC, Weihrauch D, Hari PN) EClinicalMedicine 2020 Jun;23:100361 PMID: 32529175 PMCID: PMC7280748 SCOPUS ID: 2-s2.0-85085967990 06/13/2020 25 Citations

Intralipid Increases Nitric Oxide Release from Human Endothelial Cells During Oxidative Stress. (Weihrauch D, Shumpert SD, Larson ME, McVey N, Krolikowski JG, Bamkole O, Riess ML) JPEN J Parenter Enteral Nutr 2021 Feb;45(2):295-302 PMID: 32291784 PMCID: PMC8480443 SCOPUS ID: 2-s2.0-85083448695 04/16/2020 3 Citations

Inhibition of myeloperoxidase increases revascularization and improves blood flow in a diabetic mouse model of hindlimb ischaemia. (Weihrauch D, Martin DP, Jones D, Krolikowski J, Struve J, Naylor S, Pritchard KA Jr) Diab Vasc Dis Res 2020;17(3):1479164120907971 PMID: 32223319 PMCID: PMC7510377 SCOPUS ID: 2-s2.0-85082634881 04/01/2020 5 Citations

PPARγ-Independent Side Effects of Thiazolidinediones on Mitochondrial Redox State in Rat Isolated Hearts. (Riess ML, Elorbany R, Weihrauch D, Stowe DF, Camara AKS) Cells 2020 Jan 20;9(1) PMID: 31968546 PMCID: PMC7017211 SCOPUS ID: 2-s2.0-85099486696 01/24/2020 11 Citations

Corrigendum to "Red/near infrared light stimulates release of an endothelium dependent vasodilator and rescues vascular dysfunction in a diabetes model" [Free Radic. Biol. Med. 113:157-164]. (Keszler A, Lindemer B, Weihrauch D, Jones D, Hogg N, Lohr NL) Free Radic Biol Med 2019 Feb 01;131:443 PMID: 30581102 SCOPUS ID: 2-s2.0-85058702220 12/26/2018

Wavelength-dependence of vasodilation and NO release from S-nitrosothiols and dinitrosyl iron complexes by far red/near infrared light. (Keszler A, Lindemer B, Hogg N, Weihrauch D, Lohr NL) Arch Biochem Biophys 2018 Jul 01;649:47-52 PMID: 29752896 SCOPUS ID: 2-s2.0-85047079228 05/13/2018 44 Citations

Red/near infrared light stimulates release of an endothelium dependent vasodilator and rescues vascular dysfunction in a diabetes model. (Keszler A, Lindemer B, Weihrauch D, Jones D, Hogg N, Lohr NL) Free Radic Biol Med 2017 Dec;113:157-164 PMID: 28935419 PMCID: PMC5699925 SCOPUS ID: 2-s2.0-85030756635 09/25/2017 31 Citations

Detection of TRPV4 channel current-like activity in Fawn Hooded hypertensive (FHH) rat cerebral arterial muscle cells. (Gebremedhin D, Zhang DX, Weihrauch D, Uche NN, Harder DR) PLoS One 2017;12(5):e0176796 PMID: 28472069 PMCID: PMC5417564 SCOPUS ID: 2-s2.0-85019077900 05/05/2017 8 Citations

Lipid emulsion enhances cardiac performance after ischemia-reperfusion in isolated hearts from summer-active arctic ground squirrels. (Salzman MM, Cheng Q, Deklotz RJ, Dulai GK, Douglas HF, Dikalova AE, Weihrauch D, Barnes BM, Riess ML) J Comp Physiol B 2017 Jul;187(5-6):715-724 PMID: 28364393 PMCID: PMC6145465 SCOPUS ID: 2-s2.0-85016505486 04/02/2017 8 Citations

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice. (Weihrauch D, Krolikowski JG, Jones DW, Zaman T, Bamkole O, Struve J, Pagel PS, Lohr NL, Pritchard KA Jr) J Vis Exp 2017 Mar 24(121) PMID: 28362381 PMCID: PMC5408651 SCOPUS ID: 2-s2.0-85017182155 04/01/2017 1 Citation

An IRF5 Decoy Peptide Reduces Myocardial Inflammation and Fibrosis and Improves Endothelial Cell Function in Tight-Skin Mice. (Weihrauch D, Krolikowski JG, Jones DW, Zaman T, Bamkole O, Struve J, Pillai S, Pagel PS, Lohr NL, Pritchard KA Jr) PLoS One 2016;11(4):e0151999 PMID: 27050551 PMCID: PMC4822818 SCOPUS ID: 2-s2.0-84963665146 04/07/2016 9 Citations

Alagebrium inhibits neointimal hyperplasia and restores distributions of wall shear stress by reducing downstream vascular resistance in obese and diabetic rats. (Wang H, Weihrauch D, Kersten JR, Toth JM, Passerini AG, Rajamani A, Schrepfer S, LaDisa JF Jr) Am J Physiol Heart Circ Physiol 2015 Oct;309(7):H1130-40 PMID: 26254329 PMCID: PMC4865061 SCOPUS ID: 2-s2.0-84943144084 08/09/2015 7 Citations

Isoflurane favorably modulates guanosine triphosphate cyclohydrolase-1 and endothelial nitric oxide synthase during myocardial ischemia and reperfusion injury in rats. (Baotic I, Weihrauch D, Procknow J, Vasquez-Vivar J, Ge ZD, Sudhakaran S, Warltier DC, Kersten JR) Anesthesiology 2015 Sep;123(3):582-9 PMID: 26192027 PMCID: PMC4543441 SCOPUS ID: 2-s2.0-84964697044 07/21/2015 10 Citations

A novel path of improving heart function after infarction. (Pritchard KA Jr, Weihrauch D) J Mol Cell Cardiol 2015 Jul;84:200-1 PMID: 25944086 PMCID: PMC5665170 SCOPUS ID: 2-s2.0-84930201946 05/07/2015

Porous ongrowth surfaces alter osteoblast maturation and mineralization. (Ninomiya JT, Struve JA, Krolikowski J, Hawkins M, Weihrauch D) J Biomed Mater Res A 2015 Jan;103(1):276-81 PMID: 24677492 SCOPUS ID: 2-s2.0-84912570839 03/29/2014 14 Citations

Sigma-1 receptor expression in sensory neurons and the effect of painful peripheral nerve injury. (Bangaru ML, Weihrauch D, Tang QB, Zoga V, Hogan Q, Wu HE) Mol Pain 2013 Sep 10;9:47 PMID: 24015960 PMCID: PMC3847629 SCOPUS ID: 2-s2.0-84883610229 09/11/2013 47 Citations

Inhibition of myeloperoxidase decreases vascular oxidative stress and increases vasodilatation in sickle cell disease mice. (Zhang H, Xu H, Weihrauch D, Jones DW, Jing X, Shi Y, Gourlay D, Oldham KT, Hillery CA, Pritchard KA Jr) J Lipid Res 2013 Nov;54(11):3009-15 PMID: 23956444 PMCID: PMC3793605 SCOPUS ID: 2-s2.0-84886071622 08/21/2013 34 Citations

N-acetyl lysyltyrosylcysteine amide inhibits myeloperoxidase, a novel tripeptide inhibitor. (Zhang H, Jing X, Shi Y, Xu H, Du J, Guan T, Weihrauch D, Jones DW, Wang W, Gourlay D, Oldham KT, Hillery CA, Pritchard KA Jr) J Lipid Res 2013 Nov;54(11):3016-29 PMID: 23883583 PMCID: PMC3793606 SCOPUS ID: 2-s2.0-84885993885 07/26/2013 40 Citations

Far red/near infrared light treatment promotes femoral artery collateralization in the ischemic hindlimb. (Lohr NL, Ninomiya JT, Warltier DC, Weihrauch D) J Mol Cell Cardiol 2013 Sep;62:36-42 PMID: 23702287 PMCID: PMC3747970 SCOPUS ID: 2-s2.0-84878680394 05/25/2013 19 Citations

Apolipoprotein A-1 mimetic D-4F enhances isoflurane-induced eNOS signaling and cardioprotection during acute hyperglycemia. (Baotic I, Ge ZD, Sedlic F, Coon A, Weihrauch D, Warltier DC, Kersten JR) Am J Physiol Heart Circ Physiol 2013 Jul 15;305(2):H219-27 PMID: 23666677 PMCID: PMC3726953 SCOPUS ID: 2-s2.0-84880170764 05/15/2013 18 Citations

Metal ions activate vascular endothelial cells and increase lymphocyte chemotaxis and binding. (Ninomiya JT, Kuzma SA, Schnettler TJ, Krolikowski JG, Struve JA, Weihrauch D) J Orthop Res 2013 Sep;31(9):1484-91 PMID: 23629852 PMCID: PMC3957232 SCOPUS ID: 2-s2.0-84881022485 05/01/2013 23 Citations

Intraganglionic AAV6 results in efficient and long-term gene transfer to peripheral sensory nervous system in adult rats. (Yu H, Fischer G, Ferhatovic L, Fan F, Light AR, Weihrauch D, Sapunar D, Nakai H, Park F, Hogan QH) PLoS One 2013;8(4):e61266 PMID: 23613824 PMCID: PMC3628918 SCOPUS ID: 2-s2.0-84876189197 04/25/2013 38 Citations

4F decreases IRF5 expression and activation in hearts of tight skin mice. (Xu H, Krolikowski JG, Jones DW, Ge ZD, Pagel PS, Pritchard KA Jr, Weihrauch D) PLoS One 2012;7(12):e52046 PMID: 23251680 PMCID: PMC3522636 SCOPUS ID: 2-s2.0-84871341765 12/20/2012 12 Citations

Transient repetitive exposure to low level light therapy enhances collateral blood vessel growth in the ischemic hindlimb of the tight skin mouse. (Zaidi M, Krolikowki JG, Jones DW, Pritchard KA Jr, Struve J, Nandedkar SD, Lohr NL, Pagel PS, Weihrauch D) Photochem Photobiol 2013;89(3):709-13 PMID: 23231468 PMCID: PMC3597754 SCOPUS ID: 2-s2.0-84876786479 12/13/2012 17 Citations

Absence of type VI collagen paradoxically improves cardiac function, structure, and remodeling after myocardial infarction. (Luther DJ, Thodeti CK, Shamhart PE, Adapala RK, Hodnichak C, Weihrauch D, Bonaldo P, Chilian WM, Meszaros JG) Circ Res 2012 Mar 16;110(6):851-6 PMID: 22343710 PMCID: PMC3954719 SCOPUS ID: 2-s2.0-84858705375 02/22/2012 80 Citations

Hexosamine pathway activation and O-linked-N-acetylglucosamine: novel mediators of endothelial dysfunction in hyperglycemia and diabetes. (Beyer AM, Weihrauch D) Vascul Pharmacol 2012;56(3-4):113-4 PMID: 22289438 SCOPUS ID: 2-s2.0-84858150148 02/01/2012 7 Citations

Isoflurane differentially modulates mitochondrial reactive oxygen species production via forward versus reverse electron transport flow: implications for preconditioning. (Hirata N, Shim YH, Pravdic D, Lohr NL, Pratt PF Jr, Weihrauch D, Kersten JR, Warltier DC, Bosnjak ZJ, Bienengraeber M) Anesthesiology 2011 Sep;115(3):531-40 PMID: 21862887 PMCID: PMC3337729 SCOPUS ID: 2-s2.0-80052165081 08/25/2011 64 Citations

Endothelial-cardiomyocyte crosstalk enhances pharmacological cardioprotection. (Leucker TM, Bienengraeber M, Muravyeva M, Baotic I, Weihrauch D, Brzezinska AK, Warltier DC, Kersten JR, Pratt PF Jr) J Mol Cell Cardiol 2011 Nov;51(5):803-11 PMID: 21791217 PMCID: PMC3342532 SCOPUS ID: 2-s2.0-80053236886 07/28/2011 57 Citations

Store-operated Ca2+ entry in sensory neurons: functional role and the effect of painful nerve injury. (Gemes G, Bangaru ML, Wu HE, Tang Q, Weihrauch D, Koopmeiners AS, Cruikshank JM, Kwok WM, Hogan QH) J Neurosci 2011 Mar 09;31(10):3536-49 PMID: 21389210 PMCID: PMC3565463 SCOPUS ID: 2-s2.0-79952394104 03/11/2011 86 Citations

Erratum: Role of heat shock protein 90 and endothelial nitric oxide synthase during early anesthetic and ischemic preconditioning (Anesthesiology (2009) 110 (317-325)) (Amour J, Brzezinska AK, Weihrauch D, Billstrom AR, Zielonka J, Krolikowski JG, Bienengraeber MW, Warltier DC, Pratt PF, Kersten JR) Anesthesiology August 2011;115(2):452 SCOPUS ID: 2-s2.0-79961093467 01/01/2011

Erratum: Hyperglycemia adversely modulates endothelial nitric oxide synthase during anesthetic preconditioning through tetrahydrobiopterin-and heat shock protein 90-mediated mechanisms (Anesthesiology (2010) 112 (576-585)) (Amour J, Brzezinska AK, Jager Z, Sullivan C, Weihrauch D, Du J, Vladic N, Shi Y, Warltier DC, Pratt PF, Kersten JR) Anesthesiology August 2011;115(2):452 SCOPUS ID: 2-s2.0-79961054130 01/01/2011

Abnormal fibrillin-1 expression and chronic oxidative stress mediate endothelial mesenchymal transition in a murine model of systemic sclerosis. (Xu H, Zaidi M, Struve J, Jones DW, Krolikowski JG, Nandedkar S, Lohr NL, Gadicherla A, Pagel PS, Csuka ME, Pritchard KA, Weihrauch D) Am J Physiol Cell Physiol 2011 Mar;300(3):C550-6 PMID: 21160034 PMCID: PMC3063974 SCOPUS ID: 2-s2.0-79952158516 12/17/2010 38 Citations

D-4F, an apoA-1 mimetic, decreases airway hyperresponsiveness, inflammation, and oxidative stress in a murine model of asthma. (Nandedkar SD, Weihrauch D, Xu H, Shi Y, Feroah T, Hutchins W, Rickaby DA, Duzgunes N, Hillery CA, Konduri KS, Pritchard KA Jr) J Lipid Res 2011 Mar;52(3):499-508 PMID: 21131532 PMCID: PMC3035686 SCOPUS ID: 2-s2.0-79953206963 12/07/2010 60 Citations

Altered mitochondrial membrane potential, mass, and morphology in the mononuclear cells of humans with type 2 diabetes. (Widlansky ME, Wang J, Shenouda SM, Hagen TM, Smith AR, Kizhakekuttu TJ, Kluge MA, Weihrauch D, Gutterman DD, Vita JA) Transl Res 2010 Jul;156(1):15-25 PMID: 20621033 PMCID: PMC2904361 SCOPUS ID: 2-s2.0-77953583649 07/14/2010 133 Citations

Genetic deletion of apolipoprotein A-I increases airway hyperresponsiveness, inflammation, and collagen deposition in the lung. (Wang W, Xu H, Shi Y, Nandedkar S, Zhang H, Gao H, Feroah T, Weihrauch D, Schulte ML, Jones DW, Jarzembowski J, Sorci-Thomas M, Pritchard KA Jr) J Lipid Res 2010 Sep;51(9):2560-70 PMID: 20498409 PMCID: PMC2918439 SCOPUS ID: 2-s2.0-77956861083 05/26/2010 68 Citations

Hyperglycemia adversely modulates endothelial nitric oxide synthase during anesthetic preconditioning through tetrahydrobiopterin- and heat shock protein 90-mediated mechanisms. (Amour J, Brzezinska AK, Jager Z, Sullivan C, Weihrauch D, Du J, Vladic N, Shi Y, Warltier DC, Pratt PF Jr, Kersten JR) Anesthesiology 2010 Mar;112(3):576-85 PMID: 20124983 PMCID: PMC2888104 02/04/2010

KATP channel subunits in rat dorsal root ganglia: alterations by painful axotomy. (Zoga V, Kawano T, Liang MY, Bienengraeber M, Weihrauch D, McCallum B, Gemes G, Hogan Q, Sarantopoulos C) Mol Pain 2010 Jan 26;6:6 PMID: 20102598 PMCID: PMC2825500 SCOPUS ID: 2-s2.0-77249165158 01/28/2010 65 Citations

Myocardial interstitial fluid inhibits proliferation and cardiomyocyte differentiation in pluripotent embryonic stem cells. (Van Orman JR, Weihrauch D, Warltier DC, Lough J) Am J Physiol Heart Circ Physiol 2009 Oct;297(4):H1369-76 PMID: 19633209 PMCID: PMC2770771 SCOPUS ID: 2-s2.0-70349610458 07/28/2009 1 Citation

Depletion of calcium stores in injured sensory neurons: anatomic and functional correlates. (Gemes G, Rigaud M, Weyker PD, Abram SE, Weihrauch D, Poroli M, Zoga V, Hogan QH) Anesthesiology 2009 Aug;111(2):393-405 PMID: 19602957 PMCID: PMC2885290 SCOPUS ID: 2-s2.0-68249135303 07/16/2009 15 Citations

Mechanism of differential cardiovascular response to propofol in Dahl salt-sensitive, Brown Norway, and chromosome 13-substituted consomic rat strains: role of large conductance Ca2+ and voltage-activated potassium channels. (Stadnicka A, Contney SJ, Moreno C, Weihrauch D, Bosnjak ZJ, Roman RJ, Stekiel TA) J Pharmacol Exp Ther 2009 Sep;330(3):727-35 PMID: 19541907 PMCID: PMC2729794 SCOPUS ID: 2-s2.0-70349106455 06/23/2009 7 Citations

Morphine reduces the threshold of helium preconditioning against myocardial infarction: the role of opioid receptors in rabbits. (Pagel PS, Krolikowski JG, Amour J, Warltier DC, Weihrauch D) J Cardiothorac Vasc Anesth 2009 Oct;23(5):619-24 PMID: 19231239 PMCID: PMC4401574 SCOPUS ID: 2-s2.0-67649596881 02/24/2009 34 Citations

Role of heat shock protein 90 and endothelial nitric oxide synthase during early anesthetic and ischemic preconditioning. (Amour J, Brzezinska AK, Weihrauch D, Billstrom AR, Zielonka J, Krolikowski JG, Bienengraeber MW, Warltier DC, Pratt PF Jr, Kersten JR) Anesthesiology 2009 Feb;110(2):317-25 PMID: 19194158 PMCID: PMC2730207 SCOPUS ID: 2-s2.0-61549089097 02/06/2009 55 Citations

Inhibition of glycogen synthase kinase or the apoptotic protein p53 lowers the threshold of helium cardioprotection in vivo: the role of mitochondrial permeability transition. (Pagel PS, Krolikowski JG, Pratt PF Jr, Shim YH, Amour J, Warltier DC, Weihrauch D) Anesth Analg 2008 Sep;107(3):769-75 PMID: 18713881 PMCID: PMC2569871 SCOPUS ID: 2-s2.0-51449098817 08/21/2008 33 Citations

The mechanism of helium-induced preconditioning: a direct role for nitric oxide in rabbits. (Pagel PS, Krolikowski JG, Pratt PF Jr, Shim YH, Amour J, Warltier DC, Weihrauch D) Anesth Analg 2008 Sep;107(3):762-8 PMID: 18713880 PMCID: PMC2569865 SCOPUS ID: 2-s2.0-51449099643 08/21/2008 32 Citations

Reactive oxygen species and mitochondrial adenosine triphosphate-regulated potassium channels mediate helium-induced preconditioning against myocardial infarction in vivo. (Pagel PS, Krolikowski JG, Pratt PF Jr, Shim YH, Amour J, Warltier DC, Weihrauch D) J Cardiothorac Vasc Anesth 2008 Aug;22(4):554-9 PMID: 18662630 PMCID: PMC2568984 SCOPUS ID: 2-s2.0-47749116015 07/30/2008 31 Citations

Histopathology of experimentally induced asthma in a murine model of sickle cell disease. (Nandedkar SD, Feroah TR, Hutchins W, Weihrauch D, Konduri KS, Wang J, Strunk RC, DeBaun MR, Hillery CA, Pritchard KA) Blood 2008 Sep 15;112(6):2529-38 PMID: 18579795 PMCID: PMC2532817 SCOPUS ID: 2-s2.0-55249127378 06/27/2008 46 Citations

Telokin expression and the effect of hypoxia on its phosphorylation status in smooth muscle cells from small and large pulmonary arteries. (Madden JA, Dantuma MW, Sorokina EA, Weihrauch D, Kleinman JG) Am J Physiol Lung Cell Mol Physiol 2008 Jun;294(6):L1166-73 PMID: 18375742 SCOPUS ID: 2-s2.0-48949119353 04/01/2008 10 Citations

Diabetes abolishes sildenafil-induced cGMP-dependent protein kinase-I expression and cardioprotection. (Jamnicki-Abegg M, Weihrauch D, Chiari PC, Krolikowski JG, Pagel PS, Warltier DC, Kersten JR) J Cardiovasc Pharmacol 2007 Dec;50(6):670-6 PMID: 18091584 SCOPUS ID: 2-s2.0-37349060320 12/20/2007 16 Citations

Noble gases without anesthetic properties protect myocardium against infarction by activating prosurvival signaling kinases and inhibiting mitochondrial permeability transition in vivo. (Pagel PS, Krolikowski JG, Shim YH, Venkatapuram S, Kersten JR, Weihrauch D, Warltier DC, Pratt PF Jr) Anesth Analg 2007 Sep;105(3):562-9 PMID: 17717207 SCOPUS ID: 2-s2.0-34548134885 08/25/2007 106 Citations

Effects of D-4F on vasodilation, oxidative stress, angiostatin, myocardial inflammation, and angiogenic potential in tight-skin mice. (Weihrauch D, Xu H, Shi Y, Wang J, Brien J, Jones DW, Kaul S, Komorowski RA, Csuka ME, Oldham KT, Pritchard KA) Am J Physiol Heart Circ Physiol 2007 Sep;293(3):H1432-41 PMID: 17496220 SCOPUS ID: 2-s2.0-34548433520 05/15/2007 66 Citations

Efficient transgenic rat production by a lentiviral vector. (Michalkiewicz M, Michalkiewicz T, Geurts AM, Roman RJ, Slocum GR, Singer O, Weihrauch D, Greene AS, Kaldunski M, Verma IM, Jacob HJ, Cowley AW Jr) Am J Physiol Heart Circ Physiol 2007 Jul;293(1):H881-94 PMID: 17322424 SCOPUS ID: 2-s2.0-34547112080 02/27/2007 36 Citations

Inhibition of apoptotic protein p53 lowers the threshold of isoflurane-induced cardioprotection during early reperfusion in rabbits. (Venkatapuram S, Wang C, Krolikowski JG, Weihrauch D, Kersten JR, Warltier DC, Pratt PF Jr, Pagel PS) Anesth Analg 2006 Dec;103(6):1400-5 PMID: 17122210 SCOPUS ID: 2-s2.0-33845671313 11/24/2006 35 Citations

Extracellular signal-regulated kinases trigger isoflurane preconditioning concomitant with upregulation of hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression in rats. (Wang C, Weihrauch D, Schwabe DA, Bienengraeber M, Warltier DC, Kersten JR, Pratt PF Jr, Pagel PS) Anesth Analg 2006 Aug;103(2):281-8, table of contents PMID: 16861403 SCOPUS ID: 2-s2.0-33745897224 07/25/2006 74 Citations

Gender-specificity of delayed preconditioning by isoflurane in rabbits: potential role of endothelial nitric oxide synthase. (Wang C, Chiari PC, Weihrauch D, Krolikowski JG, Warltier DC, Kersten JR, Pratt PF Jr, Pagel PS) Anesth Analg 2006 Aug;103(2):274-80, table of contents PMID: 16861402 SCOPUS ID: 2-s2.0-33746576289 07/25/2006 36 Citations

Rosiglitazone antagonizes vascular endothelial growth factor signaling and nuclear factor of activated T cells activation in cardiac valve endothelium. (Sander TL, Noll L, Klinkner DB, Weihrauch D, He BJ, Kaul S, Zangwill SD, Tweddell JS, Pritchard KA Jr, Oldham KT) Endothelium 2006;13(3):181-90 PMID: 16840174 SCOPUS ID: 2-s2.0-33746379872 07/15/2006 6 Citations

Cardioprotection by volatile anesthetics: new applications for old drugs? (Pratt PF Jr, Wang C, Weihrauch D, Bienengraeber MW, Kersten JR, Pagel PS, Warltier DC) Curr Opin Anaesthesiol 2006 Aug;19(4):397-403 PMID: 16829721 SCOPUS ID: 2-s2.0-33745894991 07/11/2006 31 Citations

Endothelium-derived microparticles inhibit human cardiac valve endothelial cell function. (Klinkner DB, Densmore JC, Kaul S, Noll L, Lim HJ, Weihrauch D, Pritchard KA Jr, Oldham KT, Sander TL) Shock 2006 Jun;25(6):575-80 PMID: 16721264 SCOPUS ID: 2-s2.0-33745602812 05/25/2006 48 Citations

The influence of B-cell lymphoma 2 protein, an antiapoptotic regulator of mitochondrial permeability transition, on isoflurane-induced and ischemic postconditioning in rabbits. (Wang C, Neff DA, Krolikowski JG, Weihrauch D, Bienengraeber M, Warltier DC, Kersten JR, Pagel PS) Anesth Analg 2006 May;102(5):1355-60 PMID: 16632808 SCOPUS ID: 2-s2.0-33646200334 04/25/2006 52 Citations

Inhibition of glycogen synthase kinase enhances isoflurane-induced protection against myocardial infarction during early reperfusion in vivo. (Pagel PS, Krolikowski JG, Neff DA, Weihrauch D, Bienengraeber M, Kersten JR, Warltier DC) Anesth Analg 2006 May;102(5):1348-54 PMID: 16632807 SCOPUS ID: 2-s2.0-33646191502 04/25/2006 59 Citations

Role of Erk1/2, p70s6K, and eNOS in isoflurane-induced cardioprotection during early reperfusion in vivo. (Krolikowski JG, Weihrauch D, Bienengraeber M, Kersten JR, Warltier DC, Pagel PS) Can J Anaesth 2006 Feb;53(2):174-82 PMID: 16434759 SCOPUS ID: 2-s2.0-33645769307 01/26/2006 83 Citations

Inhibition of mitochondrial permeability transition enhances isoflurane-induced cardioprotection during early reperfusion: the role of mitochondrial KATP channels. (Krolikowski JG, Bienengraeber M, Weihrauch D, Warltier DC, Kersten JR, Pagel PS) Anesth Analg 2005 Dec;101(6):1590-1596 PMID: 16301224 SCOPUS ID: 2-s2.0-28344451998 11/23/2005 105 Citations

Isoflurane inhibits cardiac myocyte apoptosis during oxidative and inflammatory stress by activating Akt and enhancing Bcl-2 expression. (Jamnicki-Abegg M, Weihrauch D, Pagel PS, Kersten JR, Bosnjak ZJ, Warltier DC, Bienengraeber MW) Anesthesiology 2005 Nov;103(5):1006-14 PMID: 16249675 SCOPUS ID: 2-s2.0-27644520393 10/27/2005 67 Citations

Morphine enhances isoflurane-induced postconditioning against myocardial infarction: the role of phosphatidylinositol-3-kinase and opioid receptors in rabbits. (Weihrauch D, Krolikowski JG, Bienengraeber M, Kersten JR, Warltier DC, Pagel PS) Anesth Analg 2005 Oct;101(4):942-949 PMID: 16192500 SCOPUS ID: 2-s2.0-25644448815 09/30/2005 94 Citations

Role of endothelial nitric oxide synthase as a trigger and mediator of isoflurane-induced delayed preconditioning in rabbit myocardium. (Chiari PC, Bienengraeber MW, Weihrauch D, Krolikowski JG, Kersten JR, Warltier DC, Pagel PS) Anesthesiology 2005 Jul;103(1):74-83 PMID: 15983459 SCOPUS ID: 2-s2.0-21744444010 06/29/2005 64 Citations

Cardioprotection by volatile anesthetics. (Bienengraeber MW, Weihrauch D, Kersten JR, Pagel PS, Warltier DC) Vascul Pharmacol 2005;42(5-6):243-52 PMID: 15922257 SCOPUS ID: 2-s2.0-19444371408 06/01/2005 57 Citations

Haptoglobin expression and activity during coronary collateralization. (Lohr NL, Warltier DC, Chilian WM, Weihrauch D) Am J Physiol Heart Circ Physiol 2005 Mar;288(3):H1389-95 PMID: 15550518 SCOPUS ID: 2-s2.0-13944252905 11/20/2004 25 Citations

Preconditioning by isoflurane is mediated by reactive oxygen species generated from mitochondrial electron transport chain complex III. (Ludwig LM, Tanaka K, Eells JT, Weihrauch D, Pagel PS, Kersten JR, Warltier DC) Anesth Analg 2004 Nov;99(5):1308-1315 PMID: 15502022 SCOPUS ID: 2-s2.0-6444220801 10/27/2004 62 Citations

Protein kinase C-epsilon primes the cardiac sarcolemmal adenosine triphosphate-sensitive potassium channel to modulation by isoflurane. (Aizawa K, Turner LA, Weihrauch D, Bosnjak ZJ, Kwok WM) Anesthesiology 2004 Aug;101(2):381-9 PMID: 15277921 SCOPUS ID: 2-s2.0-3343026158 07/28/2004 36 Citations

Autologous vascular smooth muscle cell-based myocardial gene therapy to induce coronary collateral growth. (Hattan N, Warltier D, Gu W, Kolz C, Chilian WM, Weihrauch D) Am J Physiol Heart Circ Physiol 2004 Aug;287(2):H488-93 PMID: 15277192 SCOPUS ID: 2-s2.0-3242656374 07/28/2004 23 Citations

Chronic hyperglycemia attenuates coronary collateral development and impairs proliferative properties of myocardial interstitial fluid by production of angiostatin. (Weihrauch D, Lohr NL, Mraovic B, Ludwig LM, Chilian WM, Pagel PS, Warltier DC, Kersten JR) Circulation 2004 May 18;109(19):2343-8 PMID: 15136506 SCOPUS ID: 2-s2.0-2442718997 05/12/2004 74 Citations

Protein kinase C translocation and Src protein tyrosine kinase activation mediate isoflurane-induced preconditioning in vivo: potential downstream targets of mitochondrial adenosine triphosphate-sensitive potassium channels and reactive oxygen species. (Ludwig LM, Weihrauch D, Kersten JR, Pagel PS, Warltier DC) Anesthesiology 2004 Mar;100(3):532-9 PMID: 15108965 SCOPUS ID: 2-s2.0-1442357312 04/28/2004 85 Citations

Angiostatin and matrix metalloprotease expression following ischemic acute renal failure. (Basile DP, Fredrich K, Weihrauch D, Hattan N, Chilian WM) Am J Physiol Renal Physiol 2004 May;286(5):F893-902 PMID: 15075185 SCOPUS ID: 2-s2.0-1942535190 04/13/2004 117 Citations

Reactive oxygen species are critical mediators of coronary collateral development in a canine model. (Gu W, Weihrauch D, Tanaka K, Tessmer JP, Pagel PS, Kersten JR, Chilian WM, Warltier DC) Am J Physiol Heart Circ Physiol 2003 Oct;285(4):H1582-9 PMID: 12816750 SCOPUS ID: 2-s2.0-0141676778 06/21/2003 48 Citations

N-acetylcysteine restores isoflurane-induced preconditioning against myocardial infarction during hyperglycemia. (Kehl F, Krolikowski JG, Weihrauch D, Pagel PS, Warltier DC, Kersten JR) Anesthesiology 2003 Jun;98(6):1384-90 PMID: 12766647 SCOPUS ID: 2-s2.0-0038443952 05/27/2003 29 Citations

L-4F, an apolipoprotein A-1 mimetic, dramatically improves vasodilation in hypercholesterolemia and sickle cell disease. (Ou J, Ou Z, Jones DW, Holzhauer S, Hatoum OA, Ackerman AW, Weihrauch DW, Gutterman DD, Guice K, Oldham KT, Hillery CA, Pritchard KA Jr) Circulation 2003 May 13;107(18):2337-41 PMID: 12732610 SCOPUS ID: 2-s2.0-0037986617 05/07/2003 137 Citations

Mitochondrial adenosine triphosphate-regulated potassium channel opening acts as a trigger for isoflurane-induced preconditioning by generating reactive oxygen species. (Tanaka K, Weihrauch D, Ludwig LM, Kersten JR, Pagel PS, Warltier DC) Anesthesiology 2003 Apr;98(4):935-43 PMID: 12657856 SCOPUS ID: 2-s2.0-0344211929 03/27/2003 116 Citations

Expression of VEGF and angiopoietins-1 and -2 during ischemia-induced coronary angiogenesis. (Matsunaga T, Warltier DC, Tessmer J, Weihrauch D, Simons M, Chilian WM) Am J Physiol Heart Circ Physiol 2003 Jul;285(1):H352-8 PMID: 12649074 SCOPUS ID: 2-s2.0-0037662854 03/22/2003 91 Citations

Reactive oxygen species modulate coronary wall shear stress and endothelial function during hyperglycemia. (Gross ER, LaDisa JF Jr, Weihrauch D, Olson LE, Kress TT, Hettrick DA, Pagel PS, Warltier DC, Kersten JR) Am J Physiol Heart Circ Physiol 2003 May;284(5):H1552-9 PMID: 12543642 SCOPUS ID: 2-s2.0-0037405062 01/25/2003 58 Citations

An intramyocardial catheter for repeated in vivo sampling of interstitial fluid. (Tessmer JP, Pagel PS, Weihrauch D, Ludwig LM, Chilian WM, Kersten JR, Warltier DC) J Pharmacol Toxicol Methods 2002;47(2):73-8 PMID: 12459145 SCOPUS ID: 2-s2.0-0036523146 12/03/2002 4 Citations

Mechanism of preconditioning by isoflurane in rabbits: a direct role for reactive oxygen species. (Tanaka K, Weihrauch D, Kehl F, Ludwig LM, LaDisa JF Jr, Kersten JR, Pagel PS, Warltier DC) Anesthesiology 2002 Dec;97(6):1485-90 PMID: 12459675 SCOPUS ID: 2-s2.0-0036895112 12/03/2002 149 Citations

Angiostatin inhibits coronary angiogenesis during impaired production of nitric oxide. (Matsunaga T, Weihrauch DW, Moniz MC, Tessmer J, Warltier DC, Chilian WM) Circulation 2002 May 07;105(18):2185-91 PMID: 11994253 SCOPUS ID: 2-s2.0-0037035480 05/08/2002 142 Citations

Acute hyperglycemia alters shear and oxidant stress in coronary arteries in vivo (Gross ER, Olson LE, Weihrauch D, Kersten JR, Hettrick DA, Pagel PS, Warltier DC) Annals of Biomedical Engineering 2000;28(SUPPL. 1) SCOPUS ID: 2-s2.0-0034508312 12/01/2000

Ischemia-induced coronary collateral growth is dependent on vascular endothelial growth factor and nitric oxide. (Matsunaga T, Warltier DC, Weihrauch DW, Moniz M, Tessmer J, Chilian WM) Circulation 2000 Dec 19;102(25):3098-103 PMID: 11120701 SCOPUS ID: 2-s2.0-0034687598 01/11/2000 200 Citations

Effects of transforming growth factor-beta and mechanical strain on osteoblast cell counts: an in vitro model for distraction osteogenesis. (Gosain AK, Song LS, Santoro T, Weihrauch D, Bosi BO, Corrao MA, Chilian WM) Plast Reconstr Surg 2000 Jan;105(1):130-6; discussion 137-9 PMID: 10626981 SCOPUS ID: 2-s2.0-0033977143 01/08/2000 21 Citations

Ischemia-induced coronary collateral angiogenesis. (Weihrauch D, Tessmer JP, Kersten JR, Pagel PS, Hettrick DA, Chilian WM, Warltier DC) Adv Exp Med Biol 1998;454:281-6 PMID: 9889902 SCOPUS ID: 2-s2.0-0032444787 01/16/1999 2 Citations

Repetitive coronary artery occlusions induce release of growth factors into the myocardial interstitium. (Weihrauch D, Tessmer J, Warltier DC, Chilian WM) Am J Physiol 1998 Sep;275(3):H969-76 PMID: 9724302 SCOPUS ID: 2-s2.0-0031678622 09/02/1998 39 Citations

Nitric oxide (NO) and oxygen radicals, but not prostaglandins, modulate fever. (Weihrauch D, Riedel W) Ann N Y Acad Sci 1997 Mar 15;813:373-82 PMID: 9100909 SCOPUS ID: 2-s2.0-0030936543 03/15/1997 25 Citations

Coordinate expression of the insulin-like growth factor system after microembolisation in porcine heart. (Kluge A, Zimmermann R, Weihrauch D, Mohri M, Sack S, Schaper J, Schaper W) Cardiovasc Res 1997 Feb;33(2):324-31 PMID: 9074696 SCOPUS ID: 2-s2.0-0031028605 02/01/1997 40 Citations

17β -estradiol enhances migration of coronary vascular smooth muscle (Weihrauch D, Patterson J, Rahman R, Chilian W) FASEB Journal 1996;10(3) SCOPUS ID: 2-s2.0-33749272435 12/01/1996

Importance of monocytes/macrophages and fibroblasts for healing of micronecroses in porcine myocardium. (Weihrauch D, Arras M, Zimmermann R, Schaper J) Mol Cell Biochem 1995 Jun 7-21;147(1-2):13-9 PMID: 7494542 SCOPUS ID: 2-s2.0-0029014286 06/07/1995 39 Citations

Expression of extracellular matrix proteins and the role of fibroblasts and macrophages in repair processes in ischemic porcine myocardium. (Weihrauch D, Zimmermann R, Arras M, Schaper J) Cell Mol Biol Res 1994;40(2):105-16 PMID: 7849762 SCOPUS ID: 2-s2.0-0028077854 01/01/1994 19 Citations

The extracellular matrix in human cardiac tissue. Part II: Vimentin, laminin, and fibronectin. (Speiser B, Weihrauch D, Riess CF, Schaper J) Cardioscience 1992 Mar;3(1):41-9 PMID: 1554870 SCOPUS ID: 2-s2.0-0026520135 03/01/1992 38 Citations

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Profiles for MCW, MU, MSOE, UWM, BCW, CW, Froedtert, and VA Faculty

Dorothee Weihrauch DVM, PhD

Research Scientist II

Publications (99)