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Gilbert C. White MD

Gilbert C. White MD

Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Hematology and Oncology
Program: Hematology


Research Experience

  • 1-Alkyl-2-acetylglycerophosphocholine Esterase
  • Antigens, CD31
  • Antigens, Human Platelet
  • Aspirin
  • Bernard-Soulier Syndrome
  • Blood Coagulation Disorders
  • Blood Platelet Disorders
  • Blood Platelets
  • Clot Retraction
  • Disintegrins
  • Factor IX
  • HELLP Syndrome
  • Hemostatic Disorders
  • Hermanski-Pudlak Syndrome
  • Integrin alpha2
  • Integrin alpha2beta1
  • Integrin alpha5beta1
  • Integrin beta3
  • Megakaryocytes
  • Platelet Activation
  • Platelet Adhesiveness
  • Platelet Aggregation
  • Platelet Aggregation Inhibitors
  • Platelet Aggregation Inhibitors
  • Platelet Factor 4
  • Platelet Function Tests
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Platelet Glycoprotein GPIb-IX Complex
  • Platelet Membrane Glycoprotein IIb
  • Platelet Membrane Glycoproteins
  • Prostaglandin Endoperoxides
  • Purpura, Thrombocytopenic
  • Purpura, Thrombocytopenic, Idiopathic
  • Purpura, Thrombotic Thrombocytopenic
  • Receptors, Adrenergic, alpha-2
  • Receptors, Collagen
  • Receptors, Thrombin
  • Ristocetin
  • Signal Transduction
  • Talin
  • Thrombasthenia
  • Thrombocytopenia
  • Thrombocytopenia, Neonatal Alloimmune
  • Thrombopoiesis
  • Thrombopoietin
  • Thromboxane A2
  • Thromboxane B2
  • Thromboxanes
  • beta-Thromboglobulin
  • von Willebrand Disease
  • von Willebrand Factor
  • Publications

  • Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signaling. (Zhang G, Xiang B, Ye S, Chrzanowska-Wodnicka M, Morris AJ, Gartner TK, Whiteheart SW, White GC 2nd, Smyth SS, Li Z) J Biol Chem 2011 Nov 11;286(45):39466-77 PMID 21940635
  • Rap1b facilitates NK cell functions via IQGAP1-mediated signalosomes. (Awasthi A, Samarakoon A, Chu H, Kamalakannan R, Quilliam LA, Chrzanowska-Wodnicka M, White GC 2nd, Malarkannan S) J Exp Med 2010 Aug 30;207(9):1923-38 PMID 20733035
  • Hemophilia: an amazing 35-year journey from the depths of HIV to the threshold of cure. (White GC) Trans Am Clin Climatol Assoc 2010;121:61-73; discussion 74-5 PMID 20697550
  • Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis. (Carbo C, Duerschmied D, Goerge T, Hattori H, Sakai J, Cifuni SM, White GC 2nd, Chrzanowska-Wodnicka M, Luo HR, Wagner DD) J Leukoc Biol 2010 Aug;88(2):313-9 PMID 20413728
  • Rap1b is critical for glycoprotein VI-mediated but not ADP receptor-mediated alpha2beta1 activation. (Wang Z, Holly SP, Larson MK, Liu J, Yuan W, Chrzanowska-Wodnicka M, White GC 2nd, Parise LV) J Thromb Haemost 2009 Apr;7(4):693-700 PMID 19192113
  • Prediction of inhibitors in hemophilia. (White GC) J Thromb Haemost 2008 Dec;6(12):2045-7 PMID 18983504
  • How we treat a hemophilia A patient with a factor VIII inhibitor. (Kempton CL, White GC 2nd) Blood 2009 Jan 1;113(1):11-7 PMID 18820129
  • Rap1b regulates B cell development, homing, and T cell-dependent humoral immunity. (Chu H, Awasthi A, White GC 2nd, Chrzanowska-Wodnicka M, Malarkannan S) J Immunol 2008 Sep 1;181(5):3373-83 PMID 18714009
  • Current status of thrombolytics-the need for better, especially safer, agents. (White GC 2nd) Thromb Res 2008;122 Suppl 3:S1-2 PMID 18710780
  • G-protein binding features and regulation of the RalGDS family member, RGL2. (Ferro E, Magrini D, Guazzi P, Fischer TH, Pistolesi S, Pogni R, White GC, Trabalzini L) Biochem J 2008 Oct 1;415(1):145-54 PMID 18540861
  • A critical role of Rap1b in B-cell trafficking and marginal zone B-cell development. (Chen Y, Yu M, Podd A, Wen R, Chrzanowska-Wodnicka M, White GC, Wang D) Blood 2008 May 1;111(9):4627-36 PMID 18319399
  • Defective angiogenesis, endothelial migration, proliferation, and MAPK signaling in Rap1b-deficient mice. (Chrzanowska-Wodnicka M, Kraus AE, Gale D, White GC 2nd, Vansluys J) Blood 2008 Mar 1;111(5):2647-56 PMID 17993608
  • Platelet secretion: indiscriminately spewed forth or highly orchestrated? (White GC 2nd, Rompietti R) J Thromb Haemost 2007 Oct;5(10):2006-8 PMID 17883697
  • Parachutes and prophylaxis: they both work! (White GC 2nd) J Thromb Haemost 2006 Jun;4(6):1226-7 PMID 16706964
  • Congenital and acquired platelet disorders: current dilemmas and treatment strategies. (White GC 2nd) Semin Hematol 2006 Jan;43(1 Suppl 1):S37-41 PMID 16427384
  • The interaction of thrombin with blood platelets. (Lundblad RL, White GC 2nd) Platelets 2005 Nov;16(7):373-85 PMID 16236598
  • Cellular immune responses in hemophilia: why do inhibitors develop in some, but not all hemophiliacs? (White GC 2nd, Kempton CL, Grimsley A, Nielsen B, Roberts HR) J Thromb Haemost 2005 Aug;3(8):1676-81 PMID 16102033
  • The Malmö International Brother Study (MIBS). Genetic defects and inhibitor development in siblings with severe hemophilia A. (Astermark J, Oldenburg J, Escobar M, White GC 2nd, Berntorp E, Malmö International Brother Study study group) Haematologica 2005 Jul;90(7):924-31 PMID 15996930
  • Therapeutic expression of the platelet-specific integrin, alphaIIbbeta3, in a murine model for Glanzmann thrombasthenia. (Fang J, Hodivala-Dilke K, Johnson BD, Du LM, Hynes RO, White GC 2nd, Wilcox DA) Blood 2005 Oct 15;106(8):2671-9 PMID 15972454
  • Gene therapy for hemophilia? (White GC 2nd, Roberts HR) J Thromb Haemost 2005 Jun;3(6):1312 PMID 15946222
  • B-domain deleted recombinant factor VIII preparations are bioequivalent to a monoclonal antibody purified plasma-derived factor VIII concentrate: a randomized, three-way crossover study. (Kessler CM, Gill JC, White GC 2nd, Shapiro A, Arkin S, Roth DA, Meng X, Lusher JM) Haemophilia 2005 Mar;11(2):84-91 PMID 15810908
  • Rap1b is required for normal platelet function and hemostasis in mice. (Chrzanowska-Wodnicka M, Smyth SS, Schoenwaelder SM, Fischer TH, White GC 2nd) J Clin Invest 2005 Mar;115(3):680-7 PMID 15696195
  • Phase I study of a novel recombinant human soluble thrombomodulin, ART-123. (Moll S, Lindley C, Pescatore S, Morrison D, Tsuruta K, Mohri M, Serada M, Sata M, Shimizu H, Yamada K, White GC 2nd) J Thromb Haemost 2004 Oct;2(10):1745-51 PMID 15456485
  • The use of recombinant factor VIIa in the treatment of bleeding disorders. (Roberts HR, Monroe DM, White GC) Blood 2004 Dec 15;104(13):3858-64 PMID 15328151
  • Cranial pseudotumour in haemophilia. (Libby EN, White GC) Haemophilia 2004 Mar;10(2):186-8 PMID 14962210
  • Induction of megakaryocytes to synthesize and store a releasable pool of human factor VIII. (Wilcox DA, Shi Q, Nurden P, Haberichter SL, Rosenberg JB, Johnson BD, Nurden AT, White GC 2nd, Montgomery RR) J Thromb Haemost 2003 Dec;1(12):2477-89 PMID 14675082
  • Mutations in and near the second calcium-binding domain of integrin alphaIIb affect the structure and function of integrin alphaIIbbeta3. (Gidwitz S, Temple B, White GC 2nd) Biochem J 2004 Apr 15;379(Pt 2):449-59 PMID 14670082
  • The partial thromboplastin time: defining an era in coagulation. (White GC 2nd) J Thromb Haemost 2003 Nov;1(11):2267-70 PMID 14629454
  • Gene therapy for platelet disorders: studies with Glanzmann's thrombasthenia. (Wilcox DA, White GC 2nd) J Thromb Haemost 2003 Nov;1(11):2300-11 PMID 14629461
  • Joint range-of-motion limitations among young males with hemophilia: prevalence and risk factors. (Soucie JM, Cianfrini C, Janco RL, Kulkarni R, Hambleton J, Evatt B, Forsyth A, Geraghty S, Hoots K, Abshire T, Curtis R, Forsberg A, Huszti H, Wagner M, White GC 2nd) Blood 2004 Apr 1;103(7):2467-73 PMID 14615381
  • Antenatal cell gene transfer: an immunological Trojan horse? (White GC 2nd) J Thromb Haemost 2003 Jan;1(1):14-5 PMID 12871533
  • Identification of T-cell epitopes in clotting factor IX and lack of tolerance in inbred mice. (Greenwood R, Wang B, Midkiff K, White GC 2nd, Lin HF, Frelinger JA) J Thromb Haemost 2003 Jan;1(1):95-102 PMID 12871545
  • The ras-binding domain of ral GDS-like protein-2 as a ras inhibitor in smooth muscle cells. (Fischer TH, Brittain J, Trabalzini L, Banes AJ, White GC, Smith CJ, Nichols TC) Biochem Biophys Res Commun 2003 Jun 13;305(4):934-40 PMID 12767920
  • Phase 1 trial of FVIII gene transfer for severe hemophilia A using a retroviral construct administered by peripheral intravenous infusion. (Powell JS, Ragni MV, White GC 2nd, Lusher JM, Hillman-Wiseman C, Moon TE, Cole V, Ramanathan-Girish S, Roehl H, Sajjadi N, Jolly DJ, Hurst D) Blood 2003 Sep 15;102(6):2038-45 PMID 12763932
  • Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex. (Zhang B, Cunningham MA, Nichols WC, Bernat JA, Seligsohn U, Pipe SW, McVey JH, Schulte-Overberg U, de Bosch NB, Ruiz-Saez A, White GC, Tuddenham EG, Kaufman RJ, Ginsburg D) Nat Genet 2003 Jun;34(2):220-5 PMID 12717434
  • Clinical use of a rapid collagen binding assay for von Willebrand factor cleaving protease in patients with thrombotic thrombocytopenic purpura. (Rick ME, Moll S, Taylor MA, Krizek DM, White GC 2nd, Aronson DL) Thromb Haemost 2002 Oct;88(4):598-604 PMID 12362230
  • Hepatitis C in adults and adolescents with hemophilia: a randomized, controlled trial of interferon alfa-2b and ribavirin. (Fried MW, Peter J, Hoots K, Gaglio PJ, Talbut D, Davis PC, Key NS, White GC, Lindblad L, Rickles FR, Abshire TC) Hepatology 2002 Oct;36(4 Pt 1):967-72 PMID 12297845
  • End-stage liver disease in persons with hemophilia and transfusion-associated infections. (Goedert JJ, Eyster ME, Lederman MM, Mandalaki T, De Moerloose P, White GC 2nd, Angiolillo AL, Luban NL, Sherman KE, Manco-Johnson M, Preiss L, Leissinger C, Kessler CM, Cohen AR, DiMichele D, Hilgartner MW, Aledort LM, Kroner BL, Rosenberg PS, Hatzakis A) Blood 2002 Sep 1;100(5):1584-9 PMID 12176875
  • Hemophilia gene therapy: update. (Monahan PE, White GC 2nd) Curr Opin Hematol 2002 Sep;9(5):430-6 PMID 12172462
  • Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton. (Bertoni A, Tadokoro S, Eto K, Pampori N, Parise LV, White GC, Shattil SJ) J Biol Chem 2002 Jul 12;277(28):25715-21 PMID 11994301
  • Use of recombinant factor IX in subjects with haemophilia B undergoing surgery. (Ragni MV, Pasi KJ, White GC, Giangrande PL, Courter SG, Tubridy KL, Recombinant FIX Surgical Study Group) Haemophilia 2002 Mar;8(2):91-7 PMID 11952843
  • A reference system approach to future standardization of laboratory tests for hemostasis. A position paper of the Joint Committee of the IFCC Scientific Division and the ISTH Scientific and Standardization Committee. (Jackson CM, White GC 2nd, Barrowcliffe T, Esnouf MP, Jespersen J, Kluft C, Lenahan J, Joint Committee of the IFCC Scientific Division and the ISTH Scientific and Standardization Committee) Thromb Haemost 2002 Jan;87(1):165-9 PMID 11848447
  • Superior mesenteric vein thrombosis with radiologically occult cause: a retrospective study of 43 cases. (Warshauer DM, Lee JK, Mauro MA, White GC 2nd) AJR Am J Roentgenol 2001 Oct;177(4):837-41 PMID 11566684
  • Gene therapy in hemophilia: clinical trials update. (White GC 2nd) Thromb Haemost 2001 Jul;86(1):172-7 PMID 11487005
  • The Malmö International Brother Study (MIBS): further support for genetic predisposition to inhibitor development in hemophilia patients. (Astermark J, Berntorp E, White GC, Kroner BL, MIBS Study Group) Haemophilia 2001 May;7(3):267-72 PMID 11380630
  • Definitions in hemophilia. Recommendation of the scientific subcommittee on factor VIII and factor IX of the scientific and standardization committee of the International Society on Thrombosis and Haemostasis. (White GC 2nd, Rosendaal F, Aledort LM, Lusher JM, Rothschild C, Ingerslev J, Factor VIII and Factor IX Subcommittee) Thromb Haemost 2001 Mar;85(3):560 PMID 11307831
  • Hemophilia factor VIII therapy. Immunological tolerance. A clinical perspective. (White GC 2nd, Greenwood R, Escobar M, Frelinger JA) Haematologica 2000 Oct;85(10 Suppl):113-6 PMID 11187862
  • Inhibition of CD40 ligand (CD154) in the treatment of factor VIII inhibitors. (Ewenstein BM, Hoots WK, Lusher JM, DiMichele D, White GC 2nd, Adelman B, Nadeau K) Haematologica 2000 Oct;85(10 Suppl):35-9 PMID 11187868
  • Fatal thrombosis associated with a hemi-fontan procedure, heparin-protamine reversal, and aprotinin. (Heindel SW, Mill MR, Freid EB, Valley RD, White GC 2nd, Norfleet EA) Anesthesiology 2001 Feb;94(2):369-71 PMID 11176109
  • Characterization of high-risk HIV-1 seronegative hemophiliacs. (Salkowitz JR, Purvis SF, Meyerson H, Zimmerman P, O'Brien TR, Aledort L, Eyster ME, Hilgartner M, Kessler C, Konkle BA, White GC 2nd, Goedert JJ, Lederman MM) Clin Immunol 2001 Feb;98(2):200-11 PMID 11161976
  • Issues with the assay of factor VIII activity in plasma and factor VIII concentrates. (Lundblad RL, Kingdon HS, Mann KG, White GC) Thromb Haemost 2000 Dec;84(6):942-8 PMID 11154139
  • Intracellular function in rehydrated lyophilized platelets. (Fischer TH, Merricks EP, Russell KE, Raymer RA, White GC, Bode AP, Nichols TC, Read MS) Br J Haematol 2000 Oct;111(1):167-74 PMID 11091197
  • Seventeen years' experience with Autoplex/Autoplex T: evaluation of inpatients with severe haemophilia A and factor VIII inhibitors at a major haemophilia centre. (White GC 2nd) Haemophilia 2000 Sep;6(5):508-12 PMID 11012694
  • Gene therapy for hemophilia: a step closer to reality. (White GC 2nd, Roberts HR) Mol Ther 2000 Mar;1(3):207-8 PMID 10933934
  • Megakaryocyte-targeted synthesis of the integrin beta(3)-subunit results in the phenotypic correction of Glanzmann thrombasthenia. (Wilcox DA, Olsen JC, Ishizawa L, Bray PF, French DL, Steeber DA, Bell WR, Griffith M, White GC 2nd) Blood 2000 Jun 15;95(12):3645-51 PMID 10845892
  • Platelet physiology and function. (White GC 2nd) Blood Coagul Fibrinolysis 2000 Apr;11 Suppl 1:S53 PMID 10850566
  • Expression and function of calcium binding domain chimeras of the integrins alpha(IIb) and alpha(5). (Gidwitz S, Lyman S, White GC 2nd) J Biol Chem 2000 Mar 3;275(9):6680-8 PMID 10692478
  • Integrin alphaIIb promoter-targeted expression of gene products in megakaryocytes derived from retrovirus-transduced human hematopoietic cells. (Wilcox DA, Olsen JC, Ishizawa L, Griffith M, White GC 2nd) Proc Natl Acad Sci U S A 1999 Aug 17;96(17):9654-9 PMID 10449749
  • Utilization of previously treated patients (PTPs), noninfected patients (NIPs), and previously untreated patients (PUPs) in the evaluation of new factor VIII and factor IX concentrates. Recommendation of the Scientific Subcommittee on Factor VIII and Factor IX of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. (White GC, DiMichele D, Mertens K, Negrier C, Peake IR, Prowse C, Schwaab R, Yoshioka A, Ingerslev J) Thromb Haemost 1999 Mar;81(3):462 PMID 10102478
  • ERGIC-53 gene structure and mutation analysis in 19 combined factors V and VIII deficiency families. (Nichols WC, Terry VH, Wheatley MA, Yang A, Zivelin A, Ciavarella N, Stefanile C, Matsushita T, Saito H, de Bosch NB, Ruiz-Saez A, Torres A, Thompson AR, Feinstein DI, White GC, Negrier C, Vinciguerra C, Aktan M, Kaufman RJ, Ginsburg D, Seligsohn U) Blood 1999 Apr 1;93(7):2261-6 PMID 10090935
  • Exclusive and persistent use of the entry coreceptor CXCR4 by human immunodeficiency virus type 1 from a subject homozygous for CCR5 delta32. (Michael NL, Nelson JA, KewalRamani VN, Chang G, O'Brien SJ, Mascola JR, Volsky B, Louder M, White GC 2nd, Littman DR, Swanstrom R, O'Brien TR) J Virol 1998 Jul;72(7):6040-7 PMID 9621067
  • Mammalian recombinant coagulation proteins: structure and function. (White GC 2nd, Pickens EM, Liles DK, Roberts HR) Transfus Sci 1998 Jun;19(2):177-89 PMID 10187042
  • Rap1b association with the platelet cytoskeleton occurs in the absence of glycoproteins IIb/IIIa. (White GC 2nd, Fischer TH, Duffy CM) Thromb Haemost 1998 Apr;79(4):832-6 PMID 9569200
  • Successful treatment of transient acquired factor X deficiency by plasmapheresis with concomitant intravenous immunoglobulin and steroid therapy. (Smith SV, Liles DK, White GC 2nd, Brecher ME) Am J Hematol 1998 Mar;57(3):245-52 PMID 9495379
  • SH2- and SH3-mediated interactions between focal adhesion kinase and Src. (Thomas JW, Ellis B, Boerner RJ, Knight WB, White GC 2nd, Schaller MD) J Biol Chem 1998 Jan 2;273(1):577-83 PMID 9417118
  • Giant platelet disorder in a patient with type 2B von Willebrand's disease. (Moll S, Lazarowski AR, White GC 2nd) Am J Hematol 1998 Jan;57(1):62-7 PMID 9423819
  • Integrin-mediated activation of focal adhesion kinase is independent of focal adhesion formation or integrin activation. Studies with activated and inhibitory beta3 cytoplasmic domain mutants. (Lyman S, Gilmore A, Burridge K, Gidwitz S, White GC 2nd) J Biol Chem 1997 Sep 5;272(36):22538-47 PMID 9278407
  • Recombinant factor IX. (White GC 2nd, Beebe A, Nielsen B) Thromb Haemost 1997 Jul;78(1):261-5 PMID 9198163
  • HIV-1 infection in a man homozygous for CCR5 delta 32. (O'Brien TR, Winkler C, Dean M, Nelson JA, Carrington M, Michael NL, White GC 2nd) Lancet 1997 Apr 26;349(9060):1219 PMID 9130945
  • A multicenter study of recombinant factor VIII (Recombinate) in previously treated patients with hemophilia A. The Recombinate Previously Treated Patient Study Group. (White GC 2nd, Courter S, Bray GL, Lee M, Gomperts ED) Thromb Haemost 1997 Apr;77(4):660-7 PMID 9134639
  • Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1. (Peterson SN, Trabalzini L, Brtva TR, Fischer T, Altschuler DL, Martelli P, Lapetina EG, Der CJ, White GC 2nd) J Biol Chem 1996 Nov 22;271(47):29903-8 PMID 8939933
  • AIDS-associated non-Hodgkin's lymphomas as primary and secondary AIDS diagnoses in hemophiliacs. Hemophilia Malignancy Study Group. (Ragni MV, Belle SH, Jaffe R, Locker J, Duerstein SL, Bass DC, Addiego JE, Aledort LM, Barron LE, Brettler DB, Buchanan GR, Gill JC, Ewenstein BM, Green D, Hilgartner MW, Hoots WK, Kisker CT, Lovrien EW, Rutherford CJ, Sanders NL, Smith KJ, Stabler SP, Swindells S, White GC 3rd, Kingsley LA) J Acquir Immune Defic Syndr Hum Retrovirol 1996 Sep;13(1):78-86 PMID 8797689
  • Pharmacokinetics of von Willebrand factor and factor VIIIC in patients with severe von Willebrand disease (type 3 VWD): estimation of the rate of factor VIIIC synthesis. Cooperative Study Groups. (Menache D, Aronson DL, Darr F, Montgomery RR, Gill JC, Kessler CM, Lusher JM, Phatak PD, Shapiro AD, Thompson AR, White GC 2nd) Br J Haematol 1996 Sep;94(4):740-5 PMID 8826903
  • The treatment of factor VIII inhibitors--a general overview. (White GC, Roberts HR) Vox Sang 1996;70 Suppl 1:19-23 PMID 8869464
  • Treatment of the hemophilias. (Moll S, White GC 2nd) Curr Opin Hematol 1995 Sep;2(5):386-94 PMID 9372024
  • Human immunodeficiency virus (HIV) type 1 infection status and in vitro susceptibility to HIV infection among high-risk HIV-1-seronegative hemophiliacs. (Lederman MM, Jackson JB, Kroner BL, White GC 3rd, Eyster ME, Aledort LM, Hilgartner MW, Kessler CM, Cohen AR, Kiger KP) J Infect Dis 1995 Jul;172(1):228-31 PMID 7797917
  • Variability of in vivo recovery of factor IX after infusion of monoclonal antibody purified factor IX concentrates in patients with hemophilia B. The Mononine Study Group. (White GC 2nd, Shapiro AD, Kurczynski EM, Kim HC, Bergman GE) Thromb Haemost 1995 May;73(5):779-84 PMID 7482403
  • Safety of high doses of a monoclonal antibody-purified factor IX concentrate. The Mononine Study Group. (Warrier I, Kasper CK, White GC 2nd, Shapiro AD, Bergman GE) Am J Hematol 1995 May;49(1):92-4 PMID 7741147
  • Safety and recovery of mononine in multiple-dose, high-dose regimens. (White GC 2nd) Acta Haematol 1995;94 Suppl 1:53-7; discussion 57-8 PMID 7571996
  • Incorporation of Rap 1b into the platelet cytoskeleton is dependent on thrombin activation and extracellular calcium. (Fischer TH, Gatling MN, McCormick F, Duffy CM, White GC 2nd) J Biol Chem 1994 Jun 24;269(25):17257-61 PMID 7516336
  • Factor VIII inhibitor assay: quantitative and qualitative assay limitations and development needs. (White GC 2nd) Semin Hematol 1994 Apr;31(2 Suppl 4):6-10 PMID 7939779
  • Risk of HIV infection and AIDS in women and girls with coagulation disorders. (Goedert JJ, Garvey L, Hilgartner MW, Blatt PM, Aledort LM, Cohen AR, Kessler CM, White GC, Mandalaki T, Cook RA) AIDS 1994 Apr;8(4):564-5 PMID 8011269
  • Summary of clinical experience with recombinant factor VIII products--Recombinate. (White GC 2nd) Ann Hematol 1994;68 Suppl 3:S7-8 PMID 8180260
  • Prevalence of hepatitis A antibodies in hemophiliacs: preliminary results from the Southeastern Delta Hepatitis Study. (Mah MW, Royce RA, Rathouz PJ, Wang JG, White GC 2nd, Janco RL, Hanna WT, Davis PC, Johnson CA, Poon MC) Vox Sang 1994;67 Suppl 1:21-2; discussion 23 PMID 8091730
  • Procreation and HIV. (Dublin S, Blatner WA, White GC 2nd, Goedert JJ) Lancet 1993 Nov 13;342(8881):1241-2 PMID 7901561
  • Hydrophobic affinity chromatography of human thrombin. (Lundblad RL, Tsai J, Wu HF, Jenzano JW, White GC 2nd, Connolly TM) Arch Biochem Biophys 1993 Apr;302(1):109-12 PMID 8470887
  • Human immunodeficiency virus-related conditions in children and adults with hemophilia: rates, relationship to CD4 counts, and predictive value. (Eyster ME, Rabkin CS, Hilgartner MW, Aledort LM, Ragni MV, Sprandio J, White GC, Eichinger S, de Moerloose P, Andes WA) Blood 1993 Feb 1;81(3):828-34 PMID 8427974
  • Cytoskeletal interactions of Rap1b in platelets. (White GC 2nd, Crawford N, Fischer TH) Adv Exp Med Biol 1993;344:187-94 PMID 8209787
  • Affinity chromatography of platelets on immobilized thrombin: retention of catalytic activity by platelet-bound thrombin. (Wu HF, White GC 2nd, Workman EF Jr, Jenzano JW, Lundblad RL) Thromb Res 1992 Aug 15;67(4):419-27 PMID 1412220
  • Incidence of lymphomas and other cancers in HIV-infected and HIV-uninfected patients with hemophilia. (Rabkin CS, Hilgartner MW, Hedberg KW, Aledort LM, Hatzakis A, Eichinger S, Eyster ME, White GC 2nd, Kessler CM, Lederman MM) JAMA 1992 Feb 26;267(8):1090-4 PMID 1735926
  • Purified factor IX using monoclonal immunoaffinity technique: clinical trials in hemophilia B and comparison to prothrombin complex concentrates. (Kim HC, McMillan CW, White GC, Bergman GE, Horton MW, Saidi P) Blood 1992 Feb 1;79(3):568-75 PMID 1531035
  • Nosocomial infection rate as a function of human immunodeficiency virus type 1 status in hemophiliacs. (Weber DJ, Becherer PR, Rutala WA, Samsa GP, Wilson MB, White GC 2nd) Am J Med 1991 Sep 16;91(3B):206S-212S PMID 1928166
  • Hepatocellular carcinoma in hemophilia. (Colombo M, Mannucci PM, Brettler DB, Girolami A, Lian EC, Rodeghiero F, Scharrer I, Smith PS, White GC 2nd) Am J Hematol 1991 Aug;37(4):243-6 PMID 1650134
  • The localization of the cAMP-dependent protein kinase phosphorylation site in the platelet rat protein, rap 1B. (Fischer TH, Collins JH, Gatling MN, White GC 2nd) FEBS Lett 1991 Jun 3;283(2):173-6 PMID 1904369
  • Hepatitis delta infection among multiply-transfused hemophiliacs. (Lemon SM, Becherer PR, Wang JG, White GC, Lesesne H, Janco RL, Hanna WT, Davis C, Johnson CA, Poon MC) Prog Clin Biol Res 1991;364:351-60 PMID 2020710
  • rap1B, a cAMP-dependent protein kinase substrate, associates with the platelet cytoskeleton. (Fischer TH, Gatling MN, Lacal JC, White GC 2nd) J Biol Chem 1990 Nov 15;265(32):19405-8 PMID 2123187
  • The development of a high-order Taylor expansion solution to the chemical rate equation for the simulation of complex biochemical systems. (Fischer TH, White GC 2nd) Comput Appl Biosci 1990 Jul;6(3):173-7 PMID 2207741
  • Human immunodeficiency virus-1 disease progression in hemophiliacs. (Becherer PR, Smiley ML, Matthews TJ, Weinhold KJ, McMillan CW, White GC 2nd) Am J Hematol 1990 Jul;34(3):204-9 PMID 2163586
  • The genomic organization of platelet glycoprotein IIIa. (Zimrin AB, Gidwitz S, Lord S, Schwartz E, Bennett JS, White GC 2nd, Poncz M) J Biol Chem 1990 May 25;265(15):8590-5 PMID 2341395
  • Wound infection rates after invasive procedures in HIV-1 seropositive versus HIV-1 seronegative hemophiliacs. (Buehrer JL, Weber DJ, Meyer AA, Becherer PR, Rutala WA, Wilson B, Smiley ML, White GC 2nd) Ann Surg 1990 Apr;211(4):492-8 PMID 2322041
  • Clinical experience of a new monoclonal antibody purified factor IX: half-life, recovery, and safety in patients with hemophilia B. (Kim HC, McMillan CW, White GC, Bergman GE, Saidi P) Semin Hematol 1990 Apr;27(2 Suppl 2):30-5 PMID 2094957
  • PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. (Newman PJ, Berndt MC, Gorski J, White GC 2nd, Lyman S, Paddock C, Muller WA) Science 1990 Mar 9;247(4947):1219-22 PMID 1690453
  • Kinetic evidence that arachidonate-induced calcium efflux from platelet microsomes involves a carrier-type ionophoric mechanism. (Fischer TH, Griffin AM, Barton DW, White GC 2nd) Biochim Biophys Acta 1990 Feb 28;1022(2):215-28 PMID 2137712
  • von Willebrand factor multimeric levels and patterns in patients with severe preeclampsia. (Thorp JM Jr, White GC 2nd, Moake JL, Bowes WA Jr) Obstet Gynecol 1990 Feb;75(2):163-7 PMID 2300343
  • Orthopaedic procedures and prognosis in hemophilic patients who are seropositive for human immunodeficiency virus. (Greene WB, DeGnore LT, White GC) J Bone Joint Surg Am 1990 Jan;72(1):2-11 PMID 2295669
  • Thrombolamban, the 22-kDa platelet substrate of cyclic AMP-dependent protein kinase, is immunologically homologous with the Ras family of GTP-binding proteins. (White TE, Lacal JC, Reep B, Fischer TH, Lapetina EG, White GC 2nd) Proc Natl Acad Sci U S A 1990 Jan;87(2):758-62 PMID 1689052
  • Cyclic AMP-dependent protein kinase does not increase calcium transport in platelet microsomes. (White GC 2nd, Barton DW, White TE, Fischer TH) Thromb Res 1989 Dec 1;56(5):575-81 PMID 2626742
  • A prospective study of human immunodeficiency virus type 1 infection and the development of AIDS in subjects with hemophilia. (Goedert JJ, Kessler CM, Aledort LM, Biggar RJ, Andes WA, White GC 2nd, Drummond JE, Vaidya K, Mann DL, Eyster ME) N Engl J Med 1989 Oct 26;321(17):1141-8 PMID 2477702
  • The identification of sarcoplasmic reticulum terminal cisternae proteins in platelets. (Fischer TH, Barton DW, Krause KH, White TE, Campbell KP, White GC 2nd) Biochem J 1989 Oct 15;263(2):605-8 PMID 2512909
  • Low incidence of thrombocytopenia with porcine mucosal heparin. A prospective multicenter study. (Rao AK, White GC, Sherman L, Colman R, Lan G, Ball AP) Arch Intern Med 1989 Jun;149(6):1285-8 PMID 2658898
  • Tendency to serious sequelae of infection with the human immunodeficiency virus in sibships with hemophilia. (Meropol NJ, Krause PR, Ratnoff OD, Eyster ME, Levine PH, White GC, Debanne S, Rowland D, Lederman MM) Arch Intern Med 1989 Apr;149(4):885-8 PMID 2705837
  • cAMP-dependent protein kinase substrates in platelets. Evidence that thrombolamban, a 22,000 dalton substrate, and the Ca++-ATPase are not associated proteins. (Fischer TH, White GC 2nd) Biochem Biophys Res Commun 1989 Mar 15;159(2):644-50 PMID 2522771
  • Use of recombinant antihemophilic factor in the treatment of two patients with classic hemophilia. (White GC 2nd, McMillan CW, Kingdon HS, Shoemaker CB) N Engl J Med 1989 Jan 19;320(3):166-70 PMID 2492083
  • Factor VIII gene and hemophilia A. (White GC 2nd, Shoemaker CB) Blood 1989 Jan;73(1):1-12 PMID 2491949
  • Enzymatic amplification of platelet-specific messenger RNA using the polymerase chain reaction. (Newman PJ, Gorski J, White GC 2nd, Gidwitz S, Cretney CJ, Aster RH) J Clin Invest 1988 Aug;82(2):739-43 PMID 3403726
  • Cellular immune response to viral peptides in patients exposed to HIV. (Ahearne PM, Matthews TJ, Lyerly HK, White GC, Bolognesi DP, Weinhold KJ) AIDS Res Hum Retroviruses 1988 Aug;4(4):259-67 PMID 2462895
  • Transmission of human immunodeficiency virus to sexual partners of hemophiliacs. (Smiley ML, White GC 2nd, Becherer P, Macik G, Matthews TJ, Weinhold KJ, McMillan C, Bolognesi D) Am J Hematol 1988 May;28(1):27-32 PMID 3369433
  • The use of high-dose intravenous gamma-globulin in acquired von Willebrand syndrome. (Macik BG, Gabriel DA, White GC 2nd, High K, Roberts H) Arch Pathol Lab Med 1988 Feb;112(2):143-6 PMID 2447856
  • Partial purification and characterization of thrombolamban, a 22,000 dalton cAMP-dependent protein kinase substrate in platelets. (Fischer TH, White GC 2nd) Biochem Biophys Res Commun 1987 Dec 16;149(2):700-6 PMID 3426596
  • An investigation of functional similarities between the sarcoplasmic reticulum and platelet calcium-dependent adenosinetriphosphatases with the inhibitors quercetin and calmidazolium. (Fischer TH, Campbell KP, White GC 2nd) Biochemistry 1987 Dec 1;26(24):8024-30 PMID 2962642
  • A conserved region at the COOH terminus of human immunodeficiency virus gp120 envelope protein contains an immunodominant epitope. (Palker TJ, Matthews TJ, Clark ME, Cianciolo GJ, Randall RR, Langlois AJ, White GC, Safai B, Snyderman R, Bolognesi DP) Proc Natl Acad Sci U S A 1987 Apr;84(8):2479-83 PMID 2436231
  • Platelet factor 4 enhances fibrin fiber polymerization. (Carr ME, White GC 2nd, Gabriel DA) Thromb Res 1987 Mar 1;45(5):539-43 PMID 3590091
  • Prolonged neonatal alloimmune thrombocytopenic purpura associated with anti-Bak(a). Two cases in siblings. (Miller DT, Etzel RA, McFarland JG, Aster RH, White GC 2nd) Am J Perinatol 1987 Jan;4(1):55-8 PMID 3790217
  • HTLV-III seroconversion associated with heat-treated factor VIII concentrate. (White GC 2nd, Matthews TJ, Weinhold KJ, Haynes BF, Cromartie HL, McMillan CW, Bolognesi DP) Lancet 1986 Mar 15;1(8481):611-2 PMID 2869318
  • Hemophilic patients with an inhibitor to factor VIII treated with high dose factor VIII concentrate. Results of a collaborative study for the evaluation of factor VIII inhibitor titer, recovery and half life of infused factor VIII. (Sultan Y, White GC, Aronstam A, Bosser C, Brackmann HH, Brochier G, Gormsen J, Mariani G, Roberts HR, Scarabin Y) Nouv Rev Fr Hematol 1986;28(2):85-9 PMID 3090516
  • HTLV-III exposure during cardiopulmonary resuscitation. (Saviteer SM, White GC, Cohen MS, Jason J) N Engl J Med 1985 Dec 19;313(25):1606-7 PMID 4069172
  • Ozone inhibits prostacyclin synthesis in pulmonary endothelium. (Friedman M, Madden MC, Saunders DS, Gammon K, White GC 2nd, Kwock L) Prostaglandins 1985 Dec;30(6):1069-83 PMID 3937180
  • Evidence that platelet and skeletal sarcoplasmic reticulum Ca2+-ATPase are structurally distinct. (Fischer TH, Campbell KP, White GC 2nd) J Biol Chem 1985 Jul 25;260(15):8996-9001 PMID 3160695
  • Glycoprotein V hydrolysis by thrombin. Lack of correlation with secretion. (White GC 2nd, Knupp CL) Thromb Res 1985 Jun 15;38(6):641-8 PMID 3161210
  • Effect of active site-modified thrombin on the hydrolysis of platelet-associated glycoprotein V by native thrombin. (Knupp CL, White GC 2nd) Blood 1985 Mar;65(3):578-83 PMID 3155976
  • The effect of platelet inhibitors on glycoprotein V hydrolysis by thrombin. (Knupp CL, White GC 2nd) Thromb Res 1984 May 1;34(3):225-31 PMID 6233749
  • Effect of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine on calcium fluxes by human platelet microsomes. (White GC 2nd) Biochem Biophys Res Commun 1984 Apr 30;120(2):474-80 PMID 6428395
  • Failure of activated prothrombin complex concentrates in a hemophiliac with an anti-factor VIII antibody. (Blatt PM, White GC 2nd, McMillan CW, Webster WP) JAMA 1984 Jan 6;251(1):67 PMID 6418898