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Ivan M. Lang DVM, PhD

Ivan M. Lang DVM, PhD

Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Gastroenterology
Program: Administration

Member of the Cancer Center
Member of the Neuroscience Research Center


I am willing to mentor a junior faculty member.


Research Experience

  • Airway Resistance
  • Asthma
  • Brain
  • Brain Stem
  • Bronchi
  • Brunner Glands
  • Deglutition
  • Deglutition Disorders
  • Digestive System Physiological Phenomena
  • Eructation
  • Esophageal Sphincter, Upper
  • Gastric Emptying
  • Gastroenterology
  • Gastrointestinal Motility
  • Gastrointestinal Transit
  • Laryngeal Nerves
  • Larynx
  • Medulla Oblongata
  • Motion Sickness
  • Mucous Membrane
  • Mucus
  • Myoelectric Complex, Migrating
  • Nervous System Physiological Phenomena
  • Neurophysiology
  • Neurosciences
  • Parasympathetic Nervous System
  • Peristalsis
  • Physiological Effects of Drugs
  • Physiology
  • Physiology, Comparative
  • Recurrent Laryngeal Nerve
  • Respiratory Mucosa
  • Respiratory Physiological Phenomena
  • Trachea
  • Vomiting
  • Clinical Expertise

  • Anatomy, Veterinary
  • Surgery, Veterinary
  • Veterinarians
  • Veterinary Drugs
  • Veterinary Medicine
  • Methodologies and Techniques

  • Airway Resistance
  • Anesthesia
  • Blotting, Western
  • Colonoscopy
  • Colorectal Surgery
  • Digestive System Surgical Procedures
  • Duodenoscopy
  • Electromyography
  • Endoscopy, Digestive System
  • Endoscopy, Gastrointestinal
  • Esophagoscopy
  • Gastroscopy
  • General Surgery
  • Histology
  • Immunohistochemistry
  • Interleukin-6
  • Laparoscopy
  • Laryngoscopy
  • Manometry
  • Microsurgery
  • Minor Surgical Procedures
  • Mucociliary Clearance
  • Neurosurgery
  • Otorhinolaryngologic Surgical Procedures
  • Proto-Oncogene Proteins c-fos
  • Pulmonary Surgical Procedures
  • Radiographic Magnification
  • Radionuclide Imaging
  • Respiratory Function Tests
  • Stereotaxic Techniques
  • Surgery, Veterinary
  • Surgical Procedures, Operative
  • Technetium Tc 99m Pentetate
  • Thoracic Surgery
  • Tomography, Emission-Computed
  • Single unit recording
  • Chronic animal experimentation
  • Force transducers
  • Publications

  • Pharyngoesophageal and cardiorespiratory interactions: potential implications for premature infants at risk of clinically significant cardiorespiratory events. (Hasenstab KA, Nawaz S, Lang IM, Shaker R, Jadcherla SR) Am J Physiol Gastrointest Liver Physiol 2019 Feb 01;316(2):G304-G312 PMID: 30543445 PMCID: PMC6397335 12/14/2018    
  • Effects of esophageal acidification on esophageal reflexes controlling the upper esophageal sphincter. (Lang IM, Medda BK, Shaker R) Am J Physiol Gastrointest Liver Physiol 2019 Jan 01;316(1):G45-G54 PMID: 30308131 PMCID: PMC6383379 10/12/2018    
  • The effect of body position on esophageal reflexes in cats: a possible mechanism of SIDS? (Lang IM, Medda BK, Shaker R, Jadcherla S) Pediatr Res 2018 03;83(3):731-738 PMID: 29166377 PMCID: PMC5902647 11/23/2017       2 Citations
  • Maturation Modulates Pharyngeal-Stimulus Provoked Pharyngeal and Respiratory Rhythms in Human Infants. (Hasenstab KA, Sitaram S, Lang IM, Shaker R, Jadcherla SR) Dysphagia 2018 02;33(1):63-75 PMID: 28828751 PMCID: PMC5792314 08/23/2017       1 Citations
  • Characterization and mechanisms of the supragastric belch in the cat. (Lang IM, Medda BK, Shaker R) Am J Physiol Gastrointest Liver Physiol 2017 Sep 01;313(3):G220-G229 PMID: 28619729 PMCID: PMC5625134 06/18/2017       1 Citations
  • Characterization and mechanisms of the pharyngeal swallow activated by stimulation of the esophagus. (Lang IM, Medda BK, Jadcherla SR, Shaker R) Am J Physiol Gastrointest Liver Physiol 2016 11 01;311(5):G827-G837 PMID: 27634013 PMCID: PMC5130554 11/03/2016       5 Citations
  • Mechanisms of airway responses to esophageal acidification in cats. (Lang IM, Haworth ST, Medda BK, Forster H, Shaker R) J Appl Physiol (1985) 2016 Apr 01;120(7):774-83 PMID: 26846551 PMCID: PMC4824039 02/06/2016    
  • The Physiology of Eructation. (Lang IM) Dysphagia 2016 Apr;31(2):121-33 PMID: 26694063 12/24/2015       4 Citations
  • The Role of Central and Enteric Nervous Systems in the Control of the Retrograde Giant Contraction. (Lang IM) J Neurogastroenterol Motil 2016 Apr 30;22(2):321-32 PMID: 26645249 PMCID: PMC4819871 12/10/2015    
  • Impaired upper esophageal sphincter reflexes in patients with supraesophageal reflux disease. (Babaei A, Venu M, Naini SR, Gonzaga J, Lang IM, Massey BT, Jadcherla S, Shaker R) Gastroenterology 2015 Nov;149(6):1381-91 PMID: 26188682 PMCID: PMC4628603 07/21/2015       15 Citations
  • Mechanism of UES relaxation initiated by gastric air distension. (Lang IM, Medda BK, Shaker R) Am J Physiol Gastrointest Liver Physiol 2014 Aug 15;307(4):G452-8 PMID: 24970778 PMCID: PMC4137114 06/28/2014       8 Citations
  • Role of peripheral reflexes in the initiation of the esophageal phase of swallowing. (Lang IM, Medda BK, Babaei A, Shaker R) Am J Physiol Gastrointest Liver Physiol 2014 Apr 15;306(8):G728-37 PMID: 24557762 PMCID: PMC3989705 02/22/2014       3 Citations
  • AMPA receptor subunits expression and phosphorylation in cingulate cortex in rats following esophageal acid exposure. (Banerjee B, Medda BK, Pochiraju S, Kannampalli P, Lang IM, Sengupta JN, Shaker R) Neurogastroenterol Motil 2013 Dec;25(12):973-e776 PMID: 24118589 PMCID: PMC4097166 10/15/2013       3 Citations
  • Digestive and respiratory tract motor responses associated with eructation. (Lang IM, Medda BK, Shaker R) Am J Physiol Gastrointest Liver Physiol 2013 Jun 01;304(11):G1044-53 PMID: 23578784 PMCID: PMC3680682 04/13/2013       4 Citations
  • The role of the superior laryngeal nerve in esophageal reflexes. (Lang IM, Medda BK, Jadcherla S, Shaker R) Am J Physiol Gastrointest Liver Physiol 2012 Jun 15;302(12):G1445-57 PMID: 22403790 PMCID: PMC3378094 03/10/2012       15 Citations
  • Neuronal plasticity in the cingulate cortex of rats following esophageal acid exposure in early life. (Banerjee B, Medda BK, Schmidt J, Lang IM, Sengupta JN, Shaker R) Gastroenterology 2011 Aug;141(2):544-52 PMID: 21616075 PMCID: PMC3152593 05/28/2011       7 Citations
  • Differential activation of medullary vagal nuclei caused by stimulation of different esophageal mechanoreceptors. (Lang IM, Medda BK, Shaker R) Brain Res 2011 Jan 12;1368:119-33 PMID: 20971087 PMCID: PMC3014375 10/26/2010       14 Citations
  • Differential activation of pontomedullary nuclei by acid perfusion of different regions of the esophagus. (Lang IM, Medda BK, Shaker R) Brain Res 2010 Sep 17;1352:94-107 PMID: 20655885 PMCID: PMC2926140 07/27/2010       5 Citations
  • Brain stem control of the phases of swallowing. (Lang IM) Dysphagia 2009 Sep;24(3):333-48 PMID: 19399555 04/29/2009       87 Citations
  • Airway responses to esophageal acidification. (Lang IM, Haworth ST, Medda BK, Roerig DL, Forster HV, Shaker R) Am J Physiol Regul Integr Comp Physiol 2008 Jan;294(1):R211-9 PMID: 17928508 10/12/2007       27 Citations
  • Response properties of the brainstem neurons of the cat following intra-esophageal acid-pepsin infusion. (Medda BK, Sengupta JN, Lang IM, Shaker R) Neuroscience 2005;135(4):1285-94 PMID: 16165290 09/17/2005       30 Citations
  • Differential activation of medullary vagal nuclei during different phases of swallowing in the cat. (Lang IM, Dean C, Medda BK, Aslam M, Shaker R) Brain Res 2004 Jul 16;1014(1-2):145-63 PMID: 15213000 06/24/2004       22 Citations
  • Relative contribution of various airway protective mechanisms to prevention of aspiration during swallowing. (Medda BK, Kern M, Ren J, Xie P, Ulualp SO, Lang IM, Shaker R) Am J Physiol Gastrointest Liver Physiol 2003 Jun;284(6):G933-9 PMID: 12529264 01/17/2003       45 Citations
  • Mechanisms of airway protection during retching, vomiting, and swallowing. (Lang IM, Dana N, Medda BK, Shaker R) Am J Physiol Gastrointest Liver Physiol 2002 Sep;283(3):G529-36 PMID: 12181164 08/16/2002       38 Citations
  • Effects of spontaneous swallows on breathing in awake goats. (Feroah TR, Forster HV, Fuentes CG, Lang IM, Beste D, Martino P, Pan L, Rice T) J Appl Physiol (1985) 2002 May;92(5):1923-35 PMID: 11960942 04/19/2002       33 Citations
  • Mechanisms of reflexes induced by esophageal distension. (Lang IM, Medda BK, Shaker R) Am J Physiol Gastrointest Liver Physiol 2001 Nov;281(5):G1246-63 PMID: 11668034 10/23/2001       83 Citations
  • Deterioration of the pharyngo-UES contractile reflex in the elderly. (Ren J, Xie P, Lang IM, Bardan E, Sui Z, Shaker R) Laryngoscope 2000 Sep;110(9):1563-6 PMID: 10983963 09/13/2000       32 Citations
  • An overview of the upper esophageal sphincter. (Lang IM, Shaker R) Curr Gastroenterol Rep 2000 Jun;2(3):185-90 PMID: 10957928 08/25/2000       27 Citations
  • Pharyngeal dysphagia in postesophagectomy patients: correlation with deglutitive biomechanics. (Easterling CS, Bousamra M 2nd, Lang IM, Kern MK, Nitschke T, Bardan E, Shaker R) Ann Thorac Surg 2000 Apr;69(4):989-92 PMID: 10800780 05/09/2000       19 Citations
  • Noxious stimulation of emesis. (Lang IM) Dig Dis Sci 1999 Aug;44(8 Suppl):58S-63S PMID: 10490041 09/18/1999       42 Citations
  • Gastrointestinal motor and myoelectric correlates of motion sickness. (Lang IM, Sarna SK, Shaker R) Am J Physiol 1999 09;277(3):G642-52 PMID: 10484390 09/14/1999       38 Citations
  • Characterization and mechanisms of the pharyngoesophageal inhibitory reflex. (Lang IM, Medda BK, Ren J, Shaker R) Am J Physiol 1998 11;275(5):G1127-36 PMID: 9815043 11/14/1998       13 Citations
  • Pharyngoglottal closure reflex: identification and characterization in a feline model. (Shaker R, Medda BK, Ren J, Jaradeh S, Xie P, Lang IM) Am J Physiol 1998 09;275(3):G521-5 PMID: 9724264 09/02/1998       36 Citations
  • Reflex mediated airway protective mechanisms against retrograde aspiration. (Shaker R, Lang IM) Am J Med 1997 Nov 24;103(5A):64S-73S PMID: 9422627 01/09/1998       29 Citations
  • Anatomy and physiology of the upper esophageal sphincter. (Lang IM, Shaker R) Am J Med 1997 Nov 24;103(5A):50S-55S PMID: 9422624 01/09/1998       62 Citations
  • Characterization of the pharyngo-UES contractile reflex in humans. (Shaker R, Ren J, Xie P, Lang IM, Bardan E, Sui Z) Am J Physiol 1997 Oct;273(4 Pt 1):G854-8 PMID: 9357827 11/14/1997       53 Citations
  • Correlation of electrical and contractile activities of the cricopharyngeus muscle in the cat. (Medda BK, Lang IM, Dodds WJ, Christl M, Kern M, Hogan WJ, Shaker R) Am J Physiol 1997 Aug;273(2 Pt 1):G470-9 PMID: 9277427 08/01/1997       23 Citations
  • Central inhibition of nitric oxide synthase modulates upper gastrointestinal motor activity. (Ohta D, Lee CW, Sarna SK, Condon RE, Lang IM) Am J Physiol 1997 Mar;272(3 Pt 1):G417-24 PMID: 9124561 03/01/1997       16 Citations
  • Initiation of esophageal secondary peristalsis by slow fluid infusion in the opossum: effect of hydrochloric acid. (Kusano M, Hogan WJ, Lang IM, Bonnevier JL, Massey BT, Shaker R) Am J Physiol 1996 Jun;270(6 Pt 1):G927-31 PMID: 8764198 06/01/1996       13 Citations
  • Inhibition of nitric oxide synthase in the brain suppresses colonic motor activity. (Ohta D, Sarna SK, Condon RE, Lang IM) Am J Physiol 1996 Apr;270(4 Pt 1):G717-24 PMID: 8928803 04/01/1996       9 Citations
  • Characterization and quantification of a pharyngo-UES contractile reflex in cats. (Medda BK, Lang IM, Layman R, Hogan WJ, Dodds WJ, Shaker R) Am J Physiol 1994 Dec;267(6 Pt 1):G972-83 PMID: 7810665 12/01/1994       50 Citations
  • An update on the physiology of the components of the upper esophageal sphincter. (Lang IM, Shaker R) Dysphagia 1994;9(4):229-32 PMID: 7805421 01/01/1994       22 Citations
  • Effect of aging on the deglutitive oral, pharyngeal, and esophageal motor function. (Shaker R, Lang IM) Dysphagia 1994;9(4):221-8 PMID: 7805420 01/01/1994       53 Citations
  • Pharyngeal, esophageal, and proximal gastric responses associated with vomiting. (Lang IM, Sarna SK, Dodds WJ) Am J Physiol 1993 Nov;265(5 Pt 1):G963-72 PMID: 7902012 11/01/1993       33 Citations
  • The role of adrenergic receptors in the initiation of vomiting and its gastrointestinal motor correlates. (Lang IM, Sarna SK) J Pharmacol Exp Ther 1992 Oct;263(1):395-403 PMID: 1357160 10/01/1992       21 Citations
  • Videoradiographic, manometric, and electromyographic analysis of canine upper esophageal sphincter. (Lang IM, Dantas RO, Cook IJ, Dodds WJ) Am J Physiol 1991 Jun;260(6 Pt 1):G911-9 PMID: 2058678 06/01/1991       56 Citations
  • Biomechanics of cricopharyngeal bars. (Dantas RO, Cook IJ, Dodds WJ, Kern MK, Lang IM, Brasseur JG) Gastroenterology 1990 Nov;99(5):1269-74 PMID: 2210235 11/01/1990       106 Citations
  • Effect of swallowed bolus variables on oral and pharyngeal phases of swallowing. (Dantas RO, Kern MK, Massey BT, Dodds WJ, Kahrilas PJ, Brasseur JG, Cook IJ, Lang IM) Am J Physiol 1990 May;258(5 Pt 1):G675-81 PMID: 2333995 05/01/1990       323 Citations
  • Digestive tract motor correlates of vomiting and nausea. (Lang IM) Can J Physiol Pharmacol 1990 Feb;68(2):242-53 PMID: 2178749 02/01/1990       44 Citations
  • Colonic motor response to a meal in dogs. (Sarna SK, Lang IM) Am J Physiol 1989 Nov;257(5 Pt 1):G830-5 PMID: 2596613 11/01/1989       32 Citations
  • Opening mechanisms of the human upper esophageal sphincter. (Cook IJ, Dodds WJ, Dantas RO, Massey B, Kern MK, Lang IM, Brasseur JG, Hogan WJ) Am J Physiol 1989 Nov;257(5 Pt 1):G748-59 PMID: 2596608 11/01/1989       280 Citations
  • Functional localization of specific receptors mediating gastrointestinal motor correlates of vomiting. (Lang IM, Marvig J) Am J Physiol 1989 Jan;256(1 Pt 1):G92-9 PMID: 2563202 01/01/1989       19 Citations
  • Cisplatin and myoelectric activity. (Lang IM) Dig Dis Sci 1988 Oct;33(10):1342-3 PMID: 3168706 10/01/1988    
  • Fentanyl and alfentanil initiate the migrating myoelectric complex but not the vomiting response in the canine small intestine. (Groner JI, Schumann R, Lang IM, Telford GL) Curr Surg 1988 May-Jun;45(3):209-11 PMID: 3135984 05/01/1988    
  • Giant migrating contractions of the canine cecum. (Sarna SK, Prasad KR, Lang IM) Am J Physiol 1988 Apr;254(4 Pt 1):G595-601 PMID: 3354678 04/01/1988       18 Citations
  • Comparison of gastrointestinal responses to CCK-8 and associated with vomiting. (Lang IM, Marvig J, Sarna SK) Am J Physiol 1988 Feb;254(2 Pt 1):G254-63 PMID: 3348377 02/01/1988       12 Citations
  • Differential effects of [Gln4]neurotensin on circular and longitudinal muscle of dog ileum in vitro. (Karaus M, Prasad KR, Sarna SK, Lang IM) Am J Physiol 1987 Oct;253(4 Pt 1):G566-72 PMID: 3661713 10/01/1987       3 Citations
  • All intense bursts of rhythmic activity may not be phase III activity. (Lang IM, Sarna SK) Am J Physiol 1987 Apr;252(4 Pt 1):G592-3 PMID: 2952018 04/01/1987       3 Citations
  • An intrinsic neural pathway for long intestino-intestinal inhibitory reflexes. (Frantzides CT, Sarna SK, Matsumoto T, Lang IM, Condon RE) Gastroenterology 1987 Mar;92(3):594-603 PMID: 3028893 03/01/1987       33 Citations
  • Gastrointestinal myoelectric correlates of vomiting in the dog. (Lang IM, Marvig J, Sarna SK, Condon RE) Am J Physiol 1986 Dec;251(6 Pt 1):G830-8 PMID: 3789149 12/01/1986       29 Citations
  • Myoelectric and contractile effects of motilin on dog small intestine in vivo. (Lang IM, Sarna SK, Condon RE) Dig Dis Sci 1986 Oct;31(10):1062-72 PMID: 3757721 10/01/1986       1 Citations
  • Generation of phases I and II of migrating myoelectric complex in the dog. (Lang IM, Sarna SK, Condon RE) Am J Physiol 1986 Aug;251(2 Pt 1):G201-7 PMID: 3740263 08/01/1986       14 Citations
  • Gastrointestinal motor correlates of vomiting in the dog: quantification and characterization as an independent phenomenon. (Lang IM, Sarna SK, Condon RE) Gastroenterology 1986 Jan;90(1):40-7 PMID: 3940253 01/01/1986       89 Citations
  • Dose- and time-dependent biphasic response to morphine on intestinal migrating myoelectric complex. (Sarna SK, Lang IM) J Pharmacol Exp Ther 1985 Sep;234(3):814-20 PMID: 2993596 09/01/1985       10 Citations
  • Mechanisms of the secretory and motor responses of the Brunner's gland region of the intestines to duodenal acidification. (Lang IM, Tansy MF) Pflugers Arch 1983 Feb;396(2):115-20 PMID: 6835814 02/01/1983       17 Citations
  • Cyclobenzaprine effects on locus coeruleus cells in tissue slice. (Lang IM, Barnes CD) Neuropharmacology 1983 Feb;22(2):249-52 PMID: 6835493 02/01/1983       4 Citations
  • Brunner's glands. (Lang IM, Tansy MF) Int Rev Physiol 1983;28:85-102 PMID: 6347930 01/01/1983       9 Citations
  • Chronic administration of naltrexone alters central catecholamine levels but not the development of hypertension in spontaneously hypertensive rats. (Strahlendorf JC, Strahlendorf HK, McKown-Pulliam R, Hughes MJ, Lang IM) Neuropharmacology 1982 Nov;21(11):1195-8 PMID: 7177344 11/01/1982       5 Citations
  • The effects of chronic administration of naltrexone on appetite and water exchange in rats. (Lang IM, Strahlendorf JC, Strahlendorf HK, Lutherer LO, Barnes CD) Pharmacol Biochem Behav 1982 Jun;16(6):909-13 PMID: 7111349 06/01/1982       29 Citations
  • Neural and hormonal control of Brunner's gland secretion. (Lang IM, Tansy MF) Life Sci 1982 Feb 01;30(5):409-17 PMID: 7038364 02/01/1982       11 Citations
  • The effects of cyclobenzaprine on locus coeruleus cells in vitro. (Lang IM, Barnes CD) Proc West Pharmacol Soc 1982;25:361-3 PMID: 7122522 01/01/1982    
  • Investigations of the preferential reduction in drinking behavior of opiate antagonists. (Lang IM, Strahlendorf JC, Strahlendorf HK, Lutherer LO, Barnes CD) Proc West Pharmacol Soc 1982;25:293-7 PMID: 7122510 01/01/1982       3 Citations
  • Effects of chronic administration of naltrexone on appetitive behaviors of rats. (Lang IM, Strahlendorf JC, Strahlendorf HK, Barnes CD) Prog Clin Biol Res 1981;68:197-207 PMID: 7301882 01/01/1981       7 Citations
  • Areas in the amygdala necessary to the operation of the vagosympathetic pressor reflex. (Lang IM, Innes DL, Tansy MF) Experientia 1979 Jan 15;35(1):57-9 PMID: 421798 01/15/1979       3 Citations
  • Last update: 01/27/2019
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