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Aron Geurts PhD

Aron Geurts PhD profile photo picture

Professor

Institution: Medical College of Wisconsin
Department: Physiology

Member of the Cardiovascular Center
Member of the Mellowes Center for Genomic Sciences and Precision Medicine


I am willing to collaborate on research projects.

View Curriculum Vitae

Research Experience

  • Animals, Genetically Modified
  • Biotechnology
  • DNA Transposable Elements
  • Genetic Engineering
  • Genetic Research
  • Organisms, Genetically Modified
  • Plasmids
  • Rats

    • Methodologies and Techniques

  • Animals, Genetically Modified
  • Biotechnology
  • Cloning, Molecular
  • Embryonic Stem Cells
  • Genetic Vectors
  • Organisms, Genetically Modified
  • Plasmids
  • Rats, Inbred BN
  • Rats, Inbred Dahl
  • Rats, Inbred Strains
  • Sequence Analysis, DNA

    • MCW Program / Core Facilities

  • Rodent Model Resource Center (Director)

    • Publications (175)

  • Creation and characterization of novel rat model for recessive dystrophic epidermolysis bullosa: Frameshift mutation of the Col7a1 gene leads to severe blistered phenotype. (Stone W, Strege C, Miller W, Geurts AM, Grzybowski M, Riddle M, Lees C, Eide C, Keene DR, Tufa SF, Seelig D, McGrath J, Tolar J) PLoS One 2024;19(5):e0302991 PMID: 38722855 PMCID: PMC11081381 05/10/2024    
  • A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats. (de Jong TV, Pan Y, Rastas P, Munro D, Tutaj M, Akil H, Benner C, Chen D, Chitre AS, Chow W, Colonna V, Dalgard CL, Demos WM, Doris PA, Garrison E, Geurts AM, Gunturkun HM, Guryev V, Hourlier T, Howe K, Huang J, Kalbfleisch T, Kim P, Li L, Mahaffey S, Martin FJ, Mohammadi P, Ozel AB, Polesskaya O, Pravenec M, Prins P, Sebat J, Smith JR, Solberg Woods LC, Tabakoff B, Tracey A, Uliano-Silva M, Villani F, Wang H, Sharp BM, Telese F, Jiang Z, Saba L, Wang X, Murphy TD, Palmer AA, Kwitek AE, Dwinell MR, Williams RW, Li JZ, Chen H) Cell Genom 2024 Apr 10;4(4):100527 PMID: 38537634 PMCID: PMC11019364 SCOPUS ID: 2-s2.0-85189630510 03/28/2024    
  • Chronic stress from adolescence to adulthood increases adiposity and anxiety in rats with decreased expression of Krtcap3. (Szalanczy AM, Fitzpatrick M, Beeson A, Bui T, Dyson C, Eller S, Landry J, Scott C, Grzybowski M, Klotz J, Geurts AM, Weiner JL, Redei EE, Solberg Woods LC) Front Genet 2023;14:1247232 PMID: 38323241 PMCID: PMC10844407 SCOPUS ID: 2-s2.0-85184221361 02/07/2024    
  • Krüppel-like factor 4 in transcriptional control of the three unique isoforms of Agouti-related peptide in mice. (Ritter ML, Wagner VA, Balapattabi K, Opichka MA, Lu KT, Wackman KK, Reho JJ, Keen HL, Kwitek AE, Morselli LL, Geurts AM, Sigmund CD, Grobe JL) Physiol Genomics 2024 Mar 01;56(3):265-275 PMID: 38145289 PMCID: PMC10866620 SCOPUS ID: 2-s2.0-85185200180 12/25/2023    
  • Histone Modifications and Their Contributions to Hypertension. (Ray A, Stelloh C, Liu Y, Meyer A, Geurts AM, Cowley AW Jr, Greene AS, Liang M, Rao S) Hypertension 2024 Feb;81(2):229-239 PMID: 38031837 SCOPUS ID: 2-s2.0-85182776843 11/30/2023       1 Citation
  • Deletion of Vβ3+CD4+ T cells by endogenous mouse mammary tumor virus 3 prevents type 1 diabetes induction by autoreactive CD8+ T cells. (Ye C, Clements SA, Gu W, Geurts AM, Mathews CE, Serreze DV, Chen YG, Driver JP) Proc Natl Acad Sci U S A 2023 Dec 05;120(49):e2312039120 PMID: 38015847 PMCID: PMC10710095 SCOPUS ID: 2-s2.0-85178500431 11/28/2023    
  • Protease-Activated Receptor 1-Mediated Damage of Podocytes in Diabetic Nephropathy. (Bohovyk R, Khedr S, Levchenko V, Stefanenko M, Semenikhina M, Kravtsova O, Isaeva E, Geurts AM, Klemens CA, Palygin O, Staruschenko A) Diabetes 2023 Dec 01;72(12):1795-1808 PMID: 37722138 PMCID: PMC10658073 SCOPUS ID: 2-s2.0-85176576178 09/18/2023       3 Citations
  • Knockout of Matrix Metalloproteinase 2 Opposes Hypertension- and Diabetes-induced Nephropathy. (Hirata T, Fan F, Fan L, Amin G, White T, Geurts AM, Kojima N, Takahashi T, Miyata N, Williams J, Roman RJ) J Cardiovasc Pharmacol 2023 Dec 01;82(6):445-457 PMID: 37643020 PMCID: PMC10691661 SCOPUS ID: 2-s2.0-85179008494 08/29/2023       1 Citation
  • Changes in environmental stress over COVID-19 pandemic likely contributed to failure to replicate adiposity phenotype associated with Krtcap3. (Szalanczy AM, Giorgio G, Goff E, Seshie O, Grzybowski M, Klotz J, Geurts AM, Redei EE, Solberg Woods LC) Physiol Genomics 2023 Oct 01;55(10):452-467 PMID: 37458463 PMCID: PMC10642928 SCOPUS ID: 2-s2.0-85170295262 07/17/2023       2 Citations
  • Aberrations in Energetic Metabolism and Stress-Related Pathways Contribute to Pathophysiology in the Neb Conditional Knockout Mouse Model of Nemaline Myopathy. (Slick RA, Tinklenberg JA, Sutton J, Zhang L, Meng H, Beatka MJ, Vanden Avond M, Prom MJ, Ott E, Montanaro F, Heisner J, Toro R, Granzier H, Geurts AM, Stowe DF, Hill RB, Lawlor MW) Am J Pathol 2023 Oct;193(10):1528-1547 PMID: 37422147 PMCID: PMC10548278 SCOPUS ID: 2-s2.0-85171390420 07/09/2023       3 Citations
  • Different Mouse Models of Nemaline Myopathy Harboring Acta1 Mutations Display Differing Abnormalities Related to Mitochondrial Biology. (Tinklenberg JA, Slick RA, Sutton J, Zhang L, Meng H, Beatka MJ, Vanden Avond M, Prom MJ, Ott E, Montanaro F, Heisner J, Toro R, Hardeman EC, Geurts AM, Stowe DF, Hill RB, Lawlor MW) Am J Pathol 2023 Oct;193(10):1548-1567 PMID: 37419385 PMCID: PMC10548277 SCOPUS ID: 2-s2.0-85171370030 07/08/2023       2 Citations
  • Robustness of single-cell RNA-seq for identifying differentially expressed genes. (Liu Y, Huang J, Pandey R, Liu P, Therani B, Qiu Q, Rao S, Geurts AM, Cowley AW Jr, Greene AS, Liang M) BMC Genomics 2023 Jul 03;24(1):371 PMID: 37394518 PMCID: PMC10316566 SCOPUS ID: 2-s2.0-85163598768 07/03/2023       1 Citation
  • Gamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia. (Gwin MS, Alexeyev MF, Geurts AM, Lee JY, Zhou C, Yang XM, Cohen MV, Downey JM, Barrington RA, Spadafora D, Audia JP, Frank DW, Voth S, Pastukh VV, Bell J, Ayers L, Tambe DT, Nelson AR, Balczon R, Lin MT, Stevens T) Am J Physiol Lung Cell Mol Physiol 2023 Aug 01;325(2):L174-L189 PMID: 37366533 PMCID: PMC10396227 SCOPUS ID: 2-s2.0-85166442544 06/27/2023       2 Citations
  • Kir7.1 knockdown and inhibition alter renal electrolyte handling but not the development of hypertension in Dahl salt-sensitive rats. (Zietara A, Palygin O, Levchenko V, Dissanayake LV, Klemens CA, Geurts A, Denton JS, Staruschenko A) Am J Physiol Renal Physiol 2023 Aug 01;325(2):F177-F187 PMID: 37318990 PMCID: PMC10393338 SCOPUS ID: 2-s2.0-85164294757 06/15/2023    
  • A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats. (de Jong TV, Pan Y, Rastas P, Munro D, Tutaj M, Akil H, Benner C, Chen D, Chitre AS, Chow W, Colonna V, Dalgard CL, Demos WM, Doris PA, Garrison E, Geurts AM, Gunturkun HM, Guryev V, Hourlier T, Howe K, Huang J, Kalbfleisch T, Kim P, Li L, Mahaffey S, Martin FJ, Mohammadi P, Ozel AB, Polesskaya O, Pravenec M, Prins P, Sebat J, Smith JR, Solberg Woods LC, Tabakoff B, Tracey A, Uliano-Silva M, Villani F, Wang H, Sharp BM, Telese F, Jiang Z, Saba L, Wang X, Murphy TD, Palmer AA, Kwitek AE, Dwinell MR, Williams RW, Li JZ, Chen H) bioRxiv 2023 Sep 28 PMID: 37214860 PMCID: PMC10197727 05/22/2023    
  • Dynamic NIR Fluorescence Imaging and Machine Learning Framework for Stratifying High vs. Low Notch-Dll4 Expressing Host Microenvironment in Triple-Negative Breast Cancer. (Shafiee S, Jagtap J, Zayats M, Epperlein J, Banerjee A, Geurts A, Flister M, Zhuk S, Joshi A) Cancers (Basel) 2023 Feb 25;15(5) PMID: 36900252 PMCID: PMC10000786 SCOPUS ID: 2-s2.0-85149856201 03/12/2023       2 Citations
  • Correction: Lenarczyk et al. T Cells Contribute to Pathological Responses in the Non-Targeted Rat Heart following Irradiation of the Kidneys. Toxics 2022, 10, 797. (Lenarczyk M, Alsheikh AJ, Cohen EP, Schaue D, Kronenberg A, Geurts A, Klawikowski S, Mattson D, Baker JE) Toxics 2023 Feb 16;11(2) PMID: 36851074 PMCID: PMC9959763 SCOPUS ID: 2-s2.0-85149176377 03/01/2023    
  • A "Four Core Genotypes" rat model to distinguish mechanisms underlying sex-biased phenotypes and diseases. (Arnold AP, Chen X, Grzybowski MN, Ryan JM, Sengelaub DR, Mohanroy T, Furlan VA, Grisham W, Malloy L, Takizawa A, Wiese CB, Vergnes L, Skaletsky H, Page DC, Reue K, Harley VR, Dwinell MR, Geurts AM) bioRxiv 2023 Feb 10 PMID: 36798326 PMCID: PMC9934672 02/18/2023    
  • Genetic Disruption of System xc-Mediated Glutamate Release from Astrocytes Increases Negative-Outcome Behaviors While Preserving Basic Brain Function in Rat. (Hess EM, Kassel SN, Simandl G, Raddatz N, Maunze B, Hurley MM, Grzybowski M, Klotz J, Geurts A, Liu QS, Choi S, Twining RC, Baker DA) J Neurosci 2023 Mar 29;43(13):2349-2361 PMID: 36788029 PMCID: PMC10072291 SCOPUS ID: 2-s2.0-85151313130 02/15/2023       1 Citation
  • Heterogeneity of Islet-Infiltrating IL-21+ CD4 T Cells in a Mouse Model of Type 1 Diabetes. (Ciecko AE, Wang Y, Harleston S, Drewek A, Serreze DV, Geurts AM, Lin CW, Chen YG) J Immunol 2023 Apr 01;210(7):935-946 PMID: 36762954 PMCID: PMC10483376 SCOPUS ID: 2-s2.0-85151043870 02/11/2023       2 Citations
  • Chronic stress from adolescence to adulthood increases adiposity and anxiety in rats with decreased expression of Krtcap3 (Szalanczy AM, Fitzpatrick M, Beeson A, Bui T, Dyson C, Eller S, Landry J, Scott C, Grzybowski M, Klotz J, Geurts AM, Weiner JL, Redei EE, Solberg Woods LC) Frontiers in Genetics 2023;14 SCOPUS ID: 2-s2.0-85184221361 01/01/2023    
  • T Cells Contribute to Pathological Responses in the Non-Targeted Rat Heart following Irradiation of the Kidneys. (Lenarczyk M, Alsheikh AJ, Cohen EP, Schaue D, Kronenberg A, Geurts A, Klawikowski S, Mattson D, Baker JE) Toxics 2022 Dec 18;10(12) PMID: 36548630 PMCID: PMC9783591 12/23/2022    
  • MDA5-dependent responses contribute to autoimmune diabetes progression and hindrance. (Blum SI, Taylor JP, Barra JM, Burg AR, Shang Q, Qiu S, Shechter O, Hayes AR, Green TJ, Geurts AM, Chen YG, Tse HM) JCI Insight 2023 Jan 24;8(2) PMID: 36512407 PMCID: PMC9977297 SCOPUS ID: 2-s2.0-85147047458 12/14/2022       3 Citations
  • Genetic Mapping of Multiple Traits Identifies Novel Genes for Adiposity, Lipids, and Insulin Secretory Capacity in Outbred Rats. (Hong-Le T, Crouse WL, Keele GR, Holl K, Seshie O, Tschannen M, Craddock A, Das SK, Szalanczy AM, McDonald B, Grzybowski M, Klotz J, Sharma NK, Geurts AM, Key CC, Hawkins G, Valdar W, Mott R, Solberg Woods LC) Diabetes 2023 Jan 01;72(1):135-148 PMID: 36219827 PMCID: PMC9797320 SCOPUS ID: 2-s2.0-85144589577 10/12/2022       4 Citations
  • Keratinocyte-associated protein 3 plays a role in body weight and adiposity with differential effects in males and females. (Szalanczy AM, Goff E, Seshie O, Deal A, Grzybowski M, Klotz J, Chuang Key CC, Geurts AM, Solberg Woods LC) Front Genet 2022;13:942574 PMID: 36212147 PMCID: PMC9535360 SCOPUS ID: 2-s2.0-85139449376 10/11/2022       6 Citations
  • Keratinocyte-associated protein 3 plays a role in body weight and adiposity with differential effects in males and females (Szalanczy AM, Goff E, Seshie O, Deal A, Grzybowski M, Klotz J, Chuang Key CC, Geurts AM, Solberg Woods LC) Frontiers in Genetics 21 September 2022;13 SCOPUS ID: 2-s2.0-85139449376 09/21/2022       6 Citations
  • Lack of xanthine dehydrogenase leads to a remarkable renal decline in a novel hypouricemic rat model (Dissanayake LV, Zietara A, Levchenko V, Spires DR, Burgos Angulo M, El-Meanawy A, Geurts AM, Dwinell MR, Palygin O, Staruschenko A) iScience 16 September 2022;25(9) SCOPUS ID: 2-s2.0-85136236916 09/16/2022       5 Citations
  • Knockout of the Circadian Clock Protein PER1 (Period1) Exacerbates Hypertension and Increases Kidney Injury in Dahl Salt-Sensitive Rats. (Zietara A, Spires DR, Juffre A, Costello HM, Crislip GR, Douma LG, Levchenko V, Dissanayake LV, Klemens CA, Nikolaienko O, Geurts AM, Gumz ML, Staruschenko A) Hypertension 2022 Nov;79(11):2519-2529 PMID: 36093781 PMCID: PMC9669134 SCOPUS ID: 2-s2.0-85140407817 09/13/2022       9 Citations
  • Lack of xanthine dehydrogenase leads to a remarkable renal decline in a novel hypouricemic rat model. (Dissanayake LV, Zietara A, Levchenko V, Spires DR, Burgos Angulo M, El-Meanawy A, Geurts AM, Dwinell MR, Palygin O, Staruschenko A) iScience 2022 Sep 16;25(9):104887 PMID: 36039296 PMCID: PMC9418856 SCOPUS ID: 2-s2.0-85136236916 08/31/2022       5 Citations
  • Advancing Physiology with Expanded Multi-Omics. (Liang M, Cowley AW Jr, Greene AS, Geurts AM, Liu P, Liu Y, Rao S) Function (Oxf) 2022;3(4):zqac031 PMID: 35801086 PMCID: PMC9247404 SCOPUS ID: 2-s2.0-85140379715 07/09/2022       1 Citation
  • Sleeve Gastrectomy Improves High-Fat Diet-Associated Hepatic Steatosis Independent of the Glucagon-like-Petpide-1 Receptor in Rats. (Barron M, Hayes H, Fernando DG, Geurts AM, Kindel TL) J Gastrointest Surg 2022 Aug;26(8):1607-1618 PMID: 35618993 PMCID: PMC9444920 SCOPUS ID: 2-s2.0-85130689967 05/27/2022    
  • Hybrid Rat Diversity Program (HRDP): A rat resource for mapping complex traits. (Dwinell M, Takizawa A, Lazcares L, Tutaj M, Schilling R, Geurts A, Kwitek A) FASEB J 2022 May;36 Suppl 1 PMID: 35560431 SCOPUS ID: 2-s2.0-85130045442 05/14/2022    
  • Btg2 mutation induces renal injury and impairs blood pressure control in female rats. (Hoffman MJ, Takizawa A, Jensen ES, Schilling R, Grzybowski M, Geurts AM, Dwinell MR) Physiol Genomics 2022 Jul 01;54(7):231-241 PMID: 35503009 PMCID: PMC9208437 SCOPUS ID: 2-s2.0-85132453480 05/04/2022       1 Citation
  • Keratinocyte-associated Protein 3May Participate in the Stress Response to Impact Adiposity (Szalanczy AM, Giorgio G, Goff E, Seshie O, Grzybowski M, Klotz J, Roberts M, Geurts AM, Redei EE, Solberg Woods LC) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1 May 2022;36 PMID: 35554436 SCOPUS ID: 2-s2.0-85130034963 05/01/2022    
  • Proximal Tubule-Specific Transgenic Overexpression of Peroxisome Proliferator-Activated Receptor Alpha Prevents the Development of Hypertension in Dahl Salt-Sensitive Rats (Yunker L, Zemaj J, Geurts A, Kriegel A) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1 May 2022;36 PMID: 35553527 SCOPUS ID: 2-s2.0-85130063017 05/01/2022    
  • Ovarian Hormone-Dependent miR-146b-5p Regulation of Plasminogen Activator Inhibitor-1 in Renal Epithelial Cells (Adam RJ, Paterson MR, Grzybowski MN, Geurts AM, Kriegel AJ) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1 May 2022;36 PMID: 35555359 SCOPUS ID: 2-s2.0-85130043534 05/01/2022    
  • SIGIRR Mutation in Human Necrotizing Enterocolitis (NEC) Disrupts STAT3-Dependent microRNA Expression in Neonatal Gut. (Yu W, Haque I, Venkatraman A, Menden HL, Mabry SM, Roy BC, Xia S, Prokop JW, Umar S, Geurts AM, Sampath V) Cell Mol Gastroenterol Hepatol 2022;13(2):425-440 PMID: 34563711 PMCID: PMC8688179 SCOPUS ID: 2-s2.0-85121348500 09/27/2021       16 Citations
  • p66Shc-mediated hydrogen peroxide production impairs nephrogenesis causing reduction of number of glomeruli. (Miller B, Palygin O, El-Meanawy A, Mattson DL, Geurts AM, Staruschenko A, Sorokin A) Life Sci 2021 Aug 15;279:119661 PMID: 34087282 PMCID: PMC8265215 SCOPUS ID: 2-s2.0-85107260373 06/05/2021       6 Citations
  • Double p52Shc/p46Shc Rat Knockout Demonstrates Severe Gait Abnormalities Accompanied by Dilated Cardiomyopathy. (Miller B, Kostrominova TY, Geurts AM, Sorokin A) Int J Mol Sci 2021 May 15;22(10) PMID: 34063460 PMCID: PMC8155973 SCOPUS ID: 2-s2.0-85105734035 06/03/2021       1 Citation
  • Double p52shc/p46shc rat knockout demonstrates severe gait abnormalities accompanied by dilated cardiomyopathy (Miller B, Kostrominova TY, Geurts AM, Sorokin A) International Journal of Molecular Sciences 2 May 2021;22(10) SCOPUS ID: 2-s2.0-85105734035 05/02/2021       1 Citation
  • Interleukin-27 is essential for type 1 diabetes development and Sjögren syndrome-like inflammation. (Ciecko AE, Foda B, Barr JY, Ramanathan S, Atkinson MA, Serreze DV, Geurts AM, Lieberman SM, Chen YG) Cell Rep 2021 Feb 02;34(5):108725 PMID: 33535031 PMCID: PMC7923249 SCOPUS ID: 2-s2.0-85100240717 02/04/2021       1 Citation
  • Erratum: Interleukin-27 is essential for type 1 diabetes development and Sjögren syndrome-like inflammation (Cell Reports (2019) 29(10) (3073–3086.e5), (S2211124719314810), (10.1016/j.celrep.2019.11.010)) (Ciecko AE, Foda B, Barr JY, Ramanathan S, Atkinson MA, Serreze DV, Geurts AM, Lieberman SM, Chen YG) Cell Reports 2 February 2021;34(5) SCOPUS ID: 2-s2.0-85100240717 02/02/2021       1 Citation
  • Generation of a novel decay accelerating factor (DAF) knock-out rat model using clustered regularly-interspaced short palindromic repeats, (CRISPR)/associated protein 9 (Cas9), genome editing (Detsika MG, Goudevenou K, Geurts AM, Gakiopoulou H, Grapsa E, Lianos EA) Transgenic Research February 2021;30(1):11-21 SCOPUS ID: 2-s2.0-85098488124 02/01/2021       4 Citations
  • Generation of a novel decay accelerating factor (DAF) knock-out rat model using clustered regularly-interspaced short palindromic repeats, (CRISPR)/associated protein 9 (Cas9), genome editing. (Detsika MG, Goudevenou K, Geurts AM, Gakiopoulou H, Grapsa E, Lianos EA) Transgenic Res 2021 Feb;30(1):11-21 PMID: 33387103 SCOPUS ID: 2-s2.0-85098488124 01/03/2021       4 Citations
  • Hyperspectral imaging approaches to characterize the distribution and expression of FRET in tissues isolated from a novel transgenic rat expressing a FRET-based probe (Annamdevula N, Geurts A, Leavesley SJ, Rich TC) Progress in Biomedical Optics and Imaging - Proceedings of SPIE 2021;11649 SCOPUS ID: 2-s2.0-85107765344 01/01/2021    
  • Assessing drug-cell and drug-tissue interactions through spectral FRET imaging (Leavesley SJ, Annamdevula N, Geurts A, Pleshinger DJ, Rich TC) Progress in Biomedical Optics and Imaging - Proceedings of SPIE 2021;11624 SCOPUS ID: 2-s2.0-85108869819 01/01/2021       1 Citation
  • Toll-Like Receptor 7 Is Required for Lacrimal Gland Autoimmunity and Type 1 Diabetes Development in Male Nonobese Diabetic Mice. (Debreceni IL, Chimenti MS, Serreze DV, Geurts AM, Chen YG, Lieberman SM) Int J Mol Sci 2020 Dec 13;21(24) PMID: 33322152 PMCID: PMC7764018 SCOPUS ID: 2-s2.0-85097667415 12/17/2020       11 Citations
  • Sexual Dimorphic Role of CD14 (Cluster of Differentiation 14) in Salt-Sensitive Hypertension and Renal Injury. (Fehrenbach DJ, Abais-Battad JM, Dasinger JH, Lund H, Keppel T, Zemaj J, Cherian-Shaw M, Gundry RL, Geurts AM, Dwinell MR, Mattson DL) Hypertension 2021 Jan;77(1):228-240 PMID: 33249861 PMCID: PMC9732708 SCOPUS ID: 2-s2.0-85097815793 12/01/2020       6 Citations
  • CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation. (Shapiro MR, Yeh WI, Longfield JR, Gallagher J, Infante CM, Wellford S, Posgai AL, Atkinson MA, Campbell-Thompson M, Lieberman SM, Serreze DV, Geurts AM, Chen YG, Brusko TM) Front Immunol 2020;11:2180 PMID: 33013915 PMCID: PMC7500101 SCOPUS ID: 2-s2.0-85091212749 10/06/2020       17 Citations
  • Mutation of RORγT reveals a role for Th17 cells in both injury and recovery from renal ischemia-reperfusion injury. (Mehrotra P, Ullah MM, Collett JA, Myers SL, Dwinell MR, Geurts AM, Basile DP) Am J Physiol Renal Physiol 2020 Nov 01;319(5):F796-F808 PMID: 32924545 PMCID: PMC7789982 SCOPUS ID: 2-s2.0-85094221372 09/15/2020       14 Citations
  • CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation (Shapiro MR, Yeh WI, Longfield JR, Gallagher J, Infante CM, Wellford S, Posgai AL, Atkinson MA, Campbell-Thompson M, Lieberman SM, Serreze DV, Geurts AM, Chen YG, Brusko TM) Frontiers in Immunology 4 September 2020;11 SCOPUS ID: 2-s2.0-85091212749 09/04/2020       17 Citations
  • UBASH3A deficiency accelerates type 1 diabetes development and enhances salivary gland inflammation in NOD mice. (Chen YG, Ciecko AE, Khaja S, Grzybowski M, Geurts AM, Lieberman SM) Sci Rep 2020 Jul 21;10(1):12019 PMID: 32694640 PMCID: PMC7374577 SCOPUS ID: 2-s2.0-85088288172 07/23/2020       9 Citations
  • Contractility of Induced Pluripotent Stem Cell-Cardiomyocytes With an MYH6 Head Domain Variant Associated With Hypoplastic Left Heart Syndrome. (Kim MS, Fleres B, Lovett J, Anfinson M, Samudrala SSK, Kelly LJ, Teigen LE, Cavanaugh M, Marquez M, Geurts AM, Lough JW, Mitchell ME, Fitts RH, Tomita-Mitchell A) Front Cell Dev Biol 2020;8:440 PMID: 32656206 PMCID: PMC7324479 SCOPUS ID: 2-s2.0-85087475806 07/14/2020       26 Citations
  • Development of an endothelial cell-restricted transgenic reporter rat: a resource for physiological studies of vascular biology. (Alexeyev M, Geurts AM, Annamdevula NS, Francis CM, Leavesley SJ, Rich TC, Taylor MS, Lin MT, Balczon R, Knighten JM, Alvarez DF, Stevens T) Am J Physiol Heart Circ Physiol 2020 Aug 01;319(2):H349-H358 PMID: 32589443 PMCID: PMC7473926 SCOPUS ID: 2-s2.0-85088491118 06/27/2020       4 Citations
  • Contractility of Induced Pluripotent Stem Cell-Cardiomyocytes With an MYH6 Head Domain Variant Associated With Hypoplastic Left Heart Syndrome (Kim MS, Fleres B, Lovett J, Anfinson M, Samudrala SSK, Kelly LJ, Teigen LE, Cavanaugh M, Marquez M, Geurts AM, Lough JW, Mitchell ME, Fitts RH, Tomita-Mitchell A) Frontiers in Cell and Developmental Biology 23 June 2020;8 SCOPUS ID: 2-s2.0-85087475806 06/23/2020       26 Citations
  • CRISPR-Mediated Single Nucleotide Polymorphism Modeling in Rats Reveals Insight Into Reduced Cardiovascular Risk Associated With Mediterranean G6PD Variant. (Kitagawa A, Kizub I, Jacob C, Michael K, D'Alessandro A, Reisz JA, Grzybowski M, Geurts AM, Rocic P, Gupte R, Miano JM, Gupte SA) Hypertension 2020 Aug;76(2):523-532 PMID: 32507041 PMCID: PMC7726709 SCOPUS ID: 2-s2.0-85088206977 06/09/2020       15 Citations
  • Endogenous miR-204 Protects the Kidney against Chronic Injury in Hypertension and Diabetes. (Cheng Y, Wang D, Wang F, Liu J, Huang B, Baker MA, Yin J, Wu R, Liu X, Regner KR, Usa K, Liu Y, Zhang C, Dong L, Geurts AM, Wang N, Miller SS, He Y, Liang M) J Am Soc Nephrol 2020 Jul;31(7):1539-1554 PMID: 32487559 PMCID: PMC7350998 SCOPUS ID: 2-s2.0-85087468924 06/04/2020       52 Citations
  • Transcriptional analysis of the multiple Sry genes and developmental program at the onset of testis differentiation in the rat. (Prokop JW, Chhetri SB, van Veen JE, Chen X, Underwood AC, Uhl K, Dwinell MR, Geurts AM, Correa SM, Arnold AP) Biol Sex Differ 2020 May 12;11(1):28 PMID: 32398044 PMCID: PMC7216353 SCOPUS ID: 2-s2.0-85084627810 05/14/2020       4 Citations
  • Interaction between Mas1 and AT1RA contributes to enhancement of skeletal muscle angiogenesis by angiotensin-(1-7) in Dahl salt-sensitive rats. (Exner EC, Geurts AM, Hoffmann BR, Casati M, Stodola T, Dsouza NR, Zimmermann M, Lombard JH, Greene AS) PLoS One 2020;15(4):e0232067 PMID: 32324784 PMCID: PMC7179868 SCOPUS ID: 2-s2.0-85083695035 04/24/2020       7 Citations
  • Diurnal Control of Blood Pressure Is Uncoupled From Sodium Excretion. (Johnston JG, Speed JS, Becker BK, Kasztan M, Soliman RH, Rhoads MK, Tao B, Jin C, Geurts AM, Hyndman KA, Pollock JS, Pollock DM) Hypertension 2020 Jun;75(6):1624-1634 PMID: 32306766 PMCID: PMC7228023 SCOPUS ID: 2-s2.0-85084695306 04/21/2020       21 Citations
  • The CD137 Ligand Is Important for Type 1 Diabetes Development but Dispensable for the Homeostasis of Disease-Suppressive CD137+ FOXP3+ Regulatory CD4 T Cells. (Foda BM, Ciecko AE, Serreze DV, Ridgway WM, Geurts AM, Chen YG) J Immunol 2020 Jun 01;204(11):2887-2899 PMID: 32295876 PMCID: PMC7296588 SCOPUS ID: 2-s2.0-85084888777 04/17/2020       8 Citations
  • Interaction between Mas1 and AT1RA contributes to enhancement of skeletal muscle angiogenesis by angiotensin-(1-7) in Dahl salt-sensitive rats (Exner EC, Geurts AM, Hoffmann BR, Casati M, Stodola T, Dsouza NR, Zimmermann M, Lombard JH, Greene AS) PLoS ONE April 2020;15(4) SCOPUS ID: 2-s2.0-85083695035 04/01/2020       7 Citations
  • Robust and replicable measurement for prepulse inhibition of the acoustic startle response. (Miller EA, Kastner DB, Grzybowski MN, Dwinell MR, Geurts AM, Frank LM) Mol Psychiatry 2021 Jun;26(6):1909-1927 PMID: 32144356 PMCID: PMC7483293 SCOPUS ID: 2-s2.0-85081733376 03/08/2020       14 Citations
  • A Mutation in γ-Adducin Impairs Autoregulation of Renal Blood Flow and Promotes the Development of Kidney Disease. (Fan F, Geurts AM, Pabbidi MR, Ge Y, Zhang C, Wang S, Liu Y, Gao W, Guo Y, Li L, He X, Lv W, Muroya Y, Hirata T, Prokop J, Booz GW, Jacob HJ, Roman RJ) J Am Soc Nephrol 2020 Apr;31(4):687-700 PMID: 32029431 PMCID: PMC7191921 SCOPUS ID: 2-s2.0-85082881644 02/08/2020       18 Citations
  • A rat model of severe VWD by elimination of the VWF gene using CRISPR/Cas9. (Garcia J, Flood VH, Haberichter SL, Fahs SA, Mattson JG, Geurts AM, Zogg M, Weiler H, Shi Q, Montgomery RR) Res Pract Thromb Haemost 2020 Jan;4(1):64-71 PMID: 31989086 PMCID: PMC6971331 SCOPUS ID: 2-s2.0-85105291983 01/29/2020       2 Citations
  • Kidney failure, arterial hypertension and left ventricular hypertrophy in rats with loss of function mutation of SOD3. (Guo H, Xu D, Kuroki M, Lu Z, Xu X, Geurts A, Osborn JW, Chen Y) Free Radic Biol Med 2020 May 20;152:787-796 PMID: 31972339 SCOPUS ID: 2-s2.0-85078520570 01/24/2020       13 Citations
  • Comparative and Functional Genomic Resource for Mechanistic Studies of Human Blood Pressure-Associated Single Nucleotide Polymorphisms. (Mishra MK, Liang EY, Geurts AM, Auer PWL, Liu P, Rao S, Greene AS, Liang M, Liu Y) Hypertension 2020 Mar;75(3):859-868 PMID: 31902252 PMCID: PMC7035167 SCOPUS ID: 2-s2.0-85081142576 01/07/2020       13 Citations
  • The severe spontaneous bleeding phenotype in a novel hemophilia A rat model is rescued by platelet FVIII expression. (Shi Q, Mattson JG, Fahs SA, Geurts AM, Weiler H, Montgomery RR) Blood Adv 2020 Jan 14;4(1):55-65 PMID: 31899798 PMCID: PMC6960468 SCOPUS ID: 2-s2.0-85078174834 01/04/2020       11 Citations
  • A galactose-1-phosphate uridylyltransferase-null rat model of classic galactosemia mimics relevant patient outcomes and reveals tissue-specific and longitudinal differences in galactose metabolism. (Rasmussen SA, Daenzer JMI, MacWilliams JA, Head ST, Williams MB, Geurts AM, Schroeder JP, Weinshenker D, Fridovich-Keil JL) J Inherit Metab Dis 2020 May;43(3):518-528 PMID: 31845342 PMCID: PMC7318568 SCOPUS ID: 2-s2.0-85077897416 12/18/2019       8 Citations
  • Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjögren Syndrome-like Inflammation. (Ciecko AE, Foda B, Barr JY, Ramanathan S, Atkinson MA, Serreze DV, Geurts AM, Lieberman SM, Chen YG) Cell Rep 2019 Dec 03;29(10):3073-3086.e5 PMID: 31801074 PMCID: PMC6914223 SCOPUS ID: 2-s2.0-85075892781 12/05/2019       31 Citations
  • Investigation of a dilated cardiomyopathy-associated variant in BAG3 using genome-edited iPSC-derived cardiomyocytes. (McDermott-Roe C, Lv W, Maximova T, Wada S, Bukowy J, Marquez M, Lai S, Shehu A, Benjamin I, Geurts A, Musunuru K) JCI Insight 2019 Nov 14;4(22) PMID: 31723063 PMCID: PMC6948852 SCOPUS ID: 2-s2.0-85077370393 11/15/2019       30 Citations
  • miR-146b-5p has a sex-specific role in renal and cardiac pathology in a rat model of chronic kidney disease. (Paterson MR, Geurts AM, Kriegel AJ) Kidney Int 2019 Dec;96(6):1332-1345 PMID: 31668631 PMCID: PMC6941490 SCOPUS ID: 2-s2.0-85074541202 11/02/2019       30 Citations
  • Knockout of P2rx7 purinergic receptor attenuates cyst growth in a rat model of ARPKD. (Arkhipov SN, Potter DL, Geurts AM, Pavlov TS) Am J Physiol Renal Physiol 2019 Dec 01;317(6):F1649-F1655 PMID: 31630543 PMCID: PMC6960783 SCOPUS ID: 2-s2.0-85075959618 10/22/2019       15 Citations
  • Habenular TCF7L2 links nicotine addiction to diabetes. (Duncan A, Heyer MP, Ishikawa M, Caligiuri SPB, Liu XA, Chen Z, Micioni Di Bonaventura MV, Elayouby KS, Ables JL, Howe WM, Bali P, Fillinger C, Williams M, O'Connor RM, Wang Z, Lu Q, Kamenecka TM, Ma'ayan A, O'Neill HC, Ibanez-Tallon I, Geurts AM, Kenny PJ) Nature 2019 Oct;574(7778):372-377 PMID: 31619789 PMCID: PMC9851388 SCOPUS ID: 2-s2.0-85073431118 10/18/2019       73 Citations
  • Synergistic Genetic Interactions between Pkhd1 and Pkd1 Result in an ARPKD-Like Phenotype in Murine Models. (Olson RJ, Hopp K, Wells H, Smith JM, Furtado J, Constans MM, Escobar DL, Geurts AM, Torres VE, Harris PC) J Am Soc Nephrol 2019 Nov;30(11):2113-2127 PMID: 31427367 PMCID: PMC6830782 SCOPUS ID: 2-s2.0-85074378541 08/21/2019       33 Citations
  • Fumarase Overexpression Abolishes Hypertension Attributable to endothelial NO synthase Haploinsufficiency in Dahl Salt-Sensitive Rats. (Xue H, Geurts AM, Usa K, Wang F, Lin Y, Phillips J, Henderson L, Baker MA, Tian Z, Liang M) Hypertension 2019 Aug;74(2):313-322 PMID: 31230549 PMCID: PMC6620137 SCOPUS ID: 2-s2.0-85069627359 06/25/2019       8 Citations
  • The p52 isoform of SHC1 is a key driver of breast cancer initiation. (Wright KD, Miller BS, El-Meanawy S, Tsaih SW, Banerjee A, Geurts AM, Sheinin Y, Sun Y, Kalyanaraman B, Rui H, Flister MJ, Sorokin A) Breast Cancer Res 2019 Jun 15;21(1):74 PMID: 31202267 PMCID: PMC6570928 SCOPUS ID: 2-s2.0-85067234098 06/17/2019       26 Citations
  • Hepatic pathology and altered gene transcription in a murine model of acid ceramidase deficiency. (Yu FPS, Molino S, Sikora J, Rasmussen S, Rybova J, Tate E, Geurts AM, Turner PV, Mckillop WM, Medin JA) Lab Invest 2019 Oct;99(10):1572-1592 PMID: 31186526 SCOPUS ID: 2-s2.0-85067402206 06/13/2019       11 Citations
  • Knockout of Dual-Specificity Protein Phosphatase 5 Protects Against Hypertension-Induced Renal Injury. (Zhang C, He X, Murphy SR, Zhang H, Wang S, Ge Y, Gao W, Williams JM, Geurts AM, Roman RJ, Fan F) J Pharmacol Exp Ther 2019 Aug;370(2):206-217 PMID: 31118214 PMCID: PMC6636243 SCOPUS ID: 2-s2.0-85070025580 05/24/2019       16 Citations
  • Telomerase Deficiency Predisposes to Heart Failure and Ischemia-Reperfusion Injury. (Ait-Aissa K, Heisner JS, Norwood Toro LE, Bruemmer D, Doyon G, Harmann L, Geurts A, Camara AKS, Beyer AM) Front Cardiovasc Med 2019;6:31 PMID: 31001540 PMCID: PMC6454001 SCOPUS ID: 2-s2.0-85078789629 04/20/2019       25 Citations
  • CD11c+ Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes. (Sandor AM, Lindsay RS, Dyjack N, Whitesell JC, Rios C, Bradley BJ, Haskins K, Serreze DV, Geurts AM, Chen YG, Seibold MA, Jacobelli J, Friedman RS) Front Immunol 2019;10:99 PMID: 30766536 PMCID: PMC6365440 SCOPUS ID: 2-s2.0-85061573541 02/16/2019       20 Citations
  • Effects of Hepatic Ischemia-Reperfusion Injuries and NRF2 on Transcriptional Activities of Bile Transporters in Rats. (Kim J, Martin A, Yee J, Fojut L, Geurts AM, Oshima K, Zimmerman MA, Hong JC) J Surg Res 2019 Mar;235:73-82 PMID: 30691853 SCOPUS ID: 2-s2.0-85055264636 01/30/2019       8 Citations
  • MiR-192-5p in the Kidney Protects Against the Development of Hypertension. (Baker MA, Wang F, Liu Y, Kriegel AJ, Geurts AM, Usa K, Xue H, Wang D, Kong Y, Liang M) Hypertension 2019 Feb;73(2):399-406 PMID: 30595117 PMCID: PMC6339564 SCOPUS ID: 2-s2.0-85059796489 01/01/2019       42 Citations
  • Integrating biology with rat genomic tools (Dwinell MR, Geurts AM) The Laboratory Rat 1 January 2019:811-825 SCOPUS ID: 2-s2.0-85094602754 01/01/2019    
  • A Screen Using iPSC-Derived Hepatocytes Reveals NAD+ as a Potential Treatment for mtDNA Depletion Syndrome. (Jing R, Corbett JL, Cai J, Beeson GC, Beeson CC, Chan SS, Dimmock DP, Lazcares L, Geurts AM, Lemasters JJ, Duncan SA) Cell Rep 2018 Nov 06;25(6):1469-1484.e5 PMID: 30404003 PMCID: PMC6289059 SCOPUS ID: 2-s2.0-85055754131 11/08/2018       38 Citations
  • A Hypermorphic Nfkbid Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8+ T Cells in NOD Mice. (Presa M, Racine JJ, Dwyer JR, Lamont DJ, Ratiu JJ, Sarsani VK, Chen YG, Geurts A, Schmitz I, Stearns T, Allocco J, Chapman HD, Serreze DV) J Immunol 2018 Oct 01;201(7):1907-1917 PMID: 30127089 PMCID: PMC6143397 SCOPUS ID: 2-s2.0-85053474331 08/22/2018       12 Citations
  • Tissue-specific effects of targeted mutation of Mir29b1 in rats. (Xue H, Zhang G, Geurts AM, Usa K, Jensen DM, Liu Y, Widlansky ME, Liang M) EBioMedicine 2018 Sep;35:260-269 PMID: 30120082 PMCID: PMC6156712 SCOPUS ID: 2-s2.0-85051562841 08/19/2018       8 Citations
  • MicroRNA-214-3p in the Kidney Contributes to the Development of Hypertension. (Liu Y, Usa K, Wang F, Liu P, Geurts AM, Li J, Williams AM, Regner KR, Kong Y, Liu H, Nie J, Liang M) J Am Soc Nephrol 2018 Oct;29(10):2518-2528 PMID: 30049682 PMCID: PMC6171279 SCOPUS ID: 2-s2.0-85053979457 07/28/2018       44 Citations
  • Protective role of Trpc6 knockout in the progression of diabetic kidney disease. (Spires D, Ilatovskaya DV, Levchenko V, North PE, Geurts AM, Palygin O, Staruschenko A) Am J Physiol Renal Physiol 2018 Oct 01;315(4):F1091-F1097 PMID: 29923767 PMCID: PMC6230750 SCOPUS ID: 2-s2.0-85056526794 06/21/2018       46 Citations
  • Sdha+/- Rats Display Minimal Muscle Pathology Without Significant Behavioral or Biochemical Abnormalities. (Siebers EM, Choi MJ, Tinklenberg JA, Beatka MJ, Ayres S, Meng H, Helbling DC, Takizawa A, Bennett B, Garces AM, Dias Duarte Machado LG, Dimmock D, Dwinell MR, Geurts AM, Lawlor MW) J Neuropathol Exp Neurol 2018 Aug 01;77(8):665-672 PMID: 29850869 PMCID: PMC6044411 SCOPUS ID: 2-s2.0-85054028838 06/01/2018       8 Citations
  • A NOX4/TRPC6 Pathway in Podocyte Calcium Regulation and Renal Damage in Diabetic Kidney Disease. (Ilatovskaya DV, Blass G, Palygin O, Levchenko V, Pavlov TS, Grzybowski MN, Winsor K, Shuyskiy LS, Geurts AM, Cowley AW Jr, Birnbaumer L, Staruschenko A) J Am Soc Nephrol 2018 Jul;29(7):1917-1927 PMID: 29793963 PMCID: PMC6050934 SCOPUS ID: 2-s2.0-85049383067 05/26/2018       94 Citations
  • Genome-wide map of proximity linkage to renin proximal promoter in rat. (Stodola TJ, Liu P, Liu Y, Vallejos AK, Geurts AM, Greene AS, Liang M) Physiol Genomics 2018 May 01;50(5):323-331 PMID: 29521603 PMCID: PMC6008118 SCOPUS ID: 2-s2.0-85061579448 03/10/2018       6 Citations
  • Characterization of Coding/Noncoding Variants for SHROOM3 in Patients with CKD. (Prokop JW, Yeo NC, Ottmann C, Chhetri SB, Florus KL, Ross EJ, Sosonkina N, Link BA, Freedman BI, Coppola CJ, McDermott-Roe C, Leysen S, Milroy LG, Meijer FA, Geurts AM, Rauscher FJ 3rd, Ramaker R, Flister MJ, Jacob HJ, Mendenhall EM, Lazar J) J Am Soc Nephrol 2018 May;29(5):1525-1535 PMID: 29476007 PMCID: PMC5967772 SCOPUS ID: 2-s2.0-85046380339 02/25/2018       32 Citations
  • miR-29 contributes to normal endothelial function and can restore it in cardiometabolic disorders. (Widlansky ME, Jensen DM, Wang J, Liu Y, Geurts AM, Kriegel AJ, Liu P, Ying R, Zhang G, Casati M, Chu C, Malik M, Branum A, Tanner MJ, Tyagi S, Usa K, Liang M) EMBO Mol Med 2018 Mar;10(3) PMID: 29374012 PMCID: PMC5840545 SCOPUS ID: 2-s2.0-85041063208 01/28/2018       72 Citations
  • Keratinocytes mediate innocuous and noxious touch via ATP-P2X4 signaling. (Moehring F, Cowie AM, Menzel AD, Weyer AD, Grzybowski M, Arzua T, Geurts AM, Palygin O, Stucky CL) Elife 2018 Jan 16;7 PMID: 29336303 PMCID: PMC5777822 SCOPUS ID: 2-s2.0-85042135972 01/18/2018       118 Citations
  • Determination of total plasma oxysterols by enzymatic hydrolysis, solid phase extraction and liquid chromatography coupled to mass-spectrometry. (Mendiara I, Domeño C, Nerín C, Geurts AM, Osada J, Martínez-Beamonte R) J Pharm Biomed Anal 2018 Feb 20;150:396-405 PMID: 29288965 SCOPUS ID: 2-s2.0-85039461303 12/31/2017       5 Citations
  • Evaluation of Vascular Control Mechanisms Utilizing Video Microscopy of Isolated Resistance Arteries of Rats. (Lukaszewicz KM, Durand MJ, Priestley JRC, Schmidt JR, Allen LA, Geurts AM, Lombard JH) J Vis Exp 2017 Dec 05(130) PMID: 29286398 PMCID: PMC5755532 SCOPUS ID: 2-s2.0-85037691517 12/30/2017    
  • Nitric oxide production by glomerular podocytes. (Palygin O, Ilatovskaya DV, Levchenko V, Endres BT, Geurts AM, Staruschenko A) Nitric Oxide 2018 Jan 30;72:24-31 PMID: 29128399 PMCID: PMC5776695 SCOPUS ID: 2-s2.0-85034073816 11/13/2017       13 Citations
  • In vitro characterization of mitochondrial function and structure in rat and human cells with a deficiency of the NADH: ubiquinone oxidoreductase Ndufc2 subunit. (Raffa S, Scrofani C, Valente S, Micaloni A, Forte M, Bianchi F, Coluccia R, Geurts AM, Sciarretta S, Volpe M, Torrisi MR, Rubattu S) Hum Mol Genet 2017 Dec 01;26(23):4541-4555 PMID: 28973657 PMCID: PMC5886163 SCOPUS ID: 2-s2.0-85042218912 10/04/2017       25 Citations
  • Essential role of Kir5.1 channels in renal salt handling and blood pressure control. (Palygin O, Levchenko V, Ilatovskaya DV, Pavlov TS, Pochynyuk OM, Jacob HJ, Geurts AM, Hodges MR, Staruschenko A) JCI Insight 2017 Sep 21;2(18) PMID: 28931751 PMCID: PMC5621918 SCOPUS ID: 2-s2.0-85049388582 09/22/2017       71 Citations
  • Active sleep unmasks apnea and delayed arousal in infant rat pups lacking central serotonin. (Young JO, Geurts A, Hodges MR, Cummings KJ) J Appl Physiol (1985) 2017 Oct 01;123(4):825-834 PMID: 28775068 PMCID: PMC5668447 SCOPUS ID: 2-s2.0-85032432081 08/05/2017       24 Citations
  • Elevation of fumarase attenuates hypertension and can result from a nonsynonymous sequence variation or increased expression depending on rat strain. (Usa K, Liu Y, Geurts AM, Cheng Y, Lazar J, Baker MA, Grzybowski M, He Y, Tian Z, Liang M) Physiol Genomics 2017 Sep 01;49(9):496-504 PMID: 28754823 PMCID: PMC5625267 SCOPUS ID: 2-s2.0-85029592375 07/30/2017       14 Citations
  • Host genetic modifiers of nonproductive angiogenesis inhibit breast cancer. (Flister MJ, Tsaih SW, Stoddard A, Plasterer C, Jagtap J, Parchur AK, Sharma G, Prisco AR, Lemke A, Murphy D, Al-Gizawiy M, Straza M, Ran S, Geurts AM, Dwinell MR, Greene AS, Bergom C, LaViolette PS, Joshi A) Breast Cancer Res Treat 2017 Aug;165(1):53-64 PMID: 28567545 PMCID: PMC6404538 SCOPUS ID: 2-s2.0-85020059895 06/02/2017       15 Citations
  • Intravital imaging of the kidney in a rat model of salt-sensitive hypertension. (Endres BT, Sandoval RM, Rhodes GJ, Campos-Bilderback SB, Kamocka MM, McDermott-Roe C, Staruschenko A, Molitoris BA, Geurts AM, Palygin O) Am J Physiol Renal Physiol 2017 Aug 01;313(2):F163-F173 PMID: 28404591 PMCID: PMC5582897 SCOPUS ID: 2-s2.0-85026777997 04/14/2017       15 Citations
  • Lung injury pathways: Adenosine receptor 2B signaling limits development of ischemic bronchiolitis obliterans organizing pneumonia. (Densmore JC, Schaid TR, Jeziorczak PM, Medhora M, Audi S, Nayak S, Auchampach J, Dwinell MR, Geurts AM, Jacobs ER) Exp Lung Res 2017 Feb;43(1):38-48 PMID: 28266889 PMCID: PMC5831175 SCOPUS ID: 2-s2.0-85014510215 03/08/2017       6 Citations
  • Efficient Precision Genome Editing in iPSCs via Genetic Co-targeting with Selection. (Mitzelfelt KA, McDermott-Roe C, Grzybowski MN, Marquez M, Kuo CT, Riedel M, Lai S, Choi MJ, Kolander KD, Helbling D, Dimmock DP, Battle MA, Jou CJ, Tristani-Firouzi M, Verbsky JW, Benjamin IJ, Geurts AM) Stem Cell Reports 2017 Mar 14;8(3):491-499 PMID: 28238794 PMCID: PMC5355643 SCOPUS ID: 2-s2.0-85013648619 02/28/2017       25 Citations
  • Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function. (McDermott-Roe C, Leleu M, Rowe GC, Palygin O, Bukowy JD, Kuo J, Rech M, Hermans-Beijnsberger S, Schaefer S, Adami E, Creemers EE, Heinig M, Schroen B, Arany Z, Petretto E, Geurts AM) PLoS One 2017;12(2):e0170458 PMID: 28158196 PMCID: PMC5291451 SCOPUS ID: 2-s2.0-85011660702 02/06/2017       8 Citations
  • ISH ADA-01 Critical role of telomerase in regulating cerebral vascular function and redox environment. (Ait-Aissa K, Hockenberry J, Gutterman D, Geurts A, Beyer A) J Hypertens 2016 Sep;34 Suppl 1 - ISH 2016 Abstract Book:e39 PMID: 27753880 10/19/2016    
  • A RATional choice for translational research? (Aitman T, Dhillon P, Geurts AM) Dis Model Mech 2016 Oct 01;9(10):1069-1072 PMID: 27736742 PMCID: PMC5087836 SCOPUS ID: 2-s2.0-84993949166 10/14/2016       40 Citations
  • ISH ADA-01 Critical role of telomerase in regulating cerebral vascular function and redox environment. (Ait-Aissa K, Hockenberry J, Gutterman D, Geurts A, Beyer A) J Hypertens 2016 Sep;34 Suppl 1:e39 PMID: 27643173 09/20/2016    
  • Early development of podocyte injury independently of hyperglycemia and elevations in arterial pressure in nondiabetic obese Dahl SS leptin receptor mutant rats. (McPherson KC, Taylor L, Johnson AC, Didion SP, Geurts AM, Garrett MR, Williams JM) Am J Physiol Renal Physiol 2016 Oct 01;311(4):F793-F804 PMID: 27465994 PMCID: PMC5142236 SCOPUS ID: 2-s2.0-84989932218 07/29/2016       16 Citations
  • Gene Editing: Practical Application in the Lab. (Geurts AM, Ekker SC) Hum Gene Ther 2016 Jun;27(6):417-8 PMID: 27322167 PMCID: PMC5583549 SCOPUS ID: 2-s2.0-84975523278 06/21/2016       1 Citation
  • p66Shc regulates renal vascular tone in hypertension-induced nephropathy. (Miller B, Palygin O, Rufanova VA, Chong A, Lazar J, Jacob HJ, Mattson D, Roman RJ, Williams JM, Cowley AW Jr, Geurts AM, Staruschenko A, Imig JD, Sorokin A) J Clin Invest 2016 Jul 01;126(7):2533-46 PMID: 27270176 PMCID: PMC4922697 SCOPUS ID: 2-s2.0-84978419542 06/09/2016       32 Citations
  • The Human 343delT HSPB5 Chaperone Associated with Early-onset Skeletal Myopathy Causes Defects in Protein Solubility. (Mitzelfelt KA, Limphong P, Choi MJ, Kondrat FD, Lai S, Kolander KD, Kwok WM, Dai Q, Grzybowski MN, Zhang H, Taylor GM, Lui Q, Thao MT, Hudson JA, Barresi R, Bushby K, Jungbluth H, Wraige E, Geurts AM, Benesch JL, Riedel M, Christians ES, Minella AC, Benjamin IJ) J Biol Chem 2016 Jul 15;291(29):14939-53 PMID: 27226619 PMCID: PMC4946913 SCOPUS ID: 2-s2.0-84978431927 05/27/2016       15 Citations
  • Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure. (Kuijk EW, Rasmussen S, Blokzijl F, Huch M, Gehart H, Toonen P, Begthel H, Clevers H, Geurts AM, Cuppen E) Sci Rep 2016 Feb 26;6:22154 PMID: 26915950 PMCID: PMC4768167 SCOPUS ID: 2-s2.0-84959258808 02/27/2016       49 Citations
  • Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease. (Rubattu S, Di Castro S, Schulz H, Geurts AM, Cotugno M, Bianchi F, Maatz H, Hummel O, Falak S, Stanzione R, Marchitti S, Scarpino S, Giusti B, Kura A, Gensini GF, Peyvandi F, Mannucci PM, Rasura M, Sciarretta S, Dwinell MR, Hubner N, Volpe M) J Am Heart Assoc 2016 Feb 17;5(2) PMID: 26888427 PMCID: PMC4802485 SCOPUS ID: 2-s2.0-84995488392 02/19/2016       43 Citations
  • Chronic central serotonin depletion attenuates ventilation and body temperature in young but not adult Tph2 knockout rats. (Kaplan K, Echert AE, Massat B, Puissant MM, Palygin O, Geurts AM, Hodges MR) J Appl Physiol (1985) 2016 May 01;120(9):1070-81 PMID: 26869713 PMCID: PMC4855209 SCOPUS ID: 2-s2.0-84984672514 02/13/2016       30 Citations
  • Potentially diagnostic electron paramagnetic resonance spectra elucidate the underlying mechanism of mitochondrial dysfunction in the deoxyguanosine kinase deficient rat model of a genetic mitochondrial DNA depletion syndrome. (Bennett B, Helbling D, Meng H, Jarzembowski J, Geurts AM, Friederich MW, Van Hove JLK, Lawlor MW, Dimmock DP) Free Radic Biol Med 2016 Mar;92:141-151 PMID: 26773591 PMCID: PMC5047058 SCOPUS ID: 2-s2.0-84957568061 01/17/2016       15 Citations
  • Evidence of the Importance of Nox4 in Production of Hypertension in Dahl Salt-Sensitive Rats. (Cowley AW Jr, Yang C, Zheleznova NN, Staruschenko A, Kurth T, Rein L, Kumar V, Sadovnikov K, Dayton A, Hoffman M, Ryan RP, Skelton MM, Salehpour F, Ranji M, Geurts A) Hypertension 2016 Feb;67(2):440-50 PMID: 26644237 PMCID: PMC4713301 SCOPUS ID: 2-s2.0-84954403695 12/09/2015       84 Citations
  • The NRF2 knockout rat: a new animal model to study endothelial dysfunction, oxidant stress, and microvascular rarefaction. (Priestley JR, Kautenburg KE, Casati MC, Endres BT, Geurts AM, Lombard JH) Am J Physiol Heart Circ Physiol 2016 Feb 15;310(4):H478-87 PMID: 26637559 PMCID: PMC4796617 SCOPUS ID: 2-s2.0-84958559081 12/08/2015       55 Citations
  • Pappa2 is linked to salt-sensitive hypertension in Dahl S rats. (Cowley AW Jr, Yang C, Kumar V, Lazar J, Jacob H, Geurts AM, Liu P, Dayton A, Kurth T, Liang M) Physiol Genomics 2016 Jan;48(1):62-72 PMID: 26534937 PMCID: PMC4757026 SCOPUS ID: 2-s2.0-84953280775 11/05/2015       29 Citations
  • Expression and function of the Scn5a-encoded voltage-gated sodium channel NaV 1.5 in the rat jejunum. (Beyder A, Gibbons SJ, Mazzone A, Strege PR, Saravanaperumal SA, Sha L, Higgins S, Eisenman ST, Bernard CE, Geurts A, Kline CF, Mohler PJ, Farrugia G) Neurogastroenterol Motil 2016 Jan;28(1):64-73 PMID: 26459913 PMCID: PMC4688076 SCOPUS ID: 2-s2.0-84952637081 10/16/2015       13 Citations
  • Myosin Id is required for planar cell polarity in ciliated tracheal and ependymal epithelial cells. (Hegan PS, Ostertag E, Geurts AM, Mooseker MS) Cytoskeleton (Hoboken) 2015 Oct;72(10):503-16 PMID: 26446290 PMCID: PMC4715625 SCOPUS ID: 2-s2.0-84954392734 10/09/2015       28 Citations
  • Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension. (Nayak S, Khan MA, Wan TC, Pei H, Linden J, Dwinell MR, Geurts AM, Imig JD, Auchampach JA) Purinergic Signal 2015 Dec;11(4):519-31 PMID: 26385692 PMCID: PMC4648794 SCOPUS ID: 2-s2.0-84947616348 09/20/2015       9 Citations
  • Two-photon Imaging of Intracellular Ca2+ Handling and Nitric Oxide Production in Endothelial and Smooth Muscle Cells of an Isolated Rat Aorta. (Endres BT, Staruschenko A, Schulte M, Geurts AM, Palygin O) J Vis Exp 2015 Jun 10(100):e52734 PMID: 26132549 PMCID: PMC4545029 SCOPUS ID: 2-s2.0-84941241987 07/02/2015       4 Citations
  • Antithrombin III/SerpinC1 insufficiency exacerbates renal ischemia/reperfusion injury. (Wang F, Zhang G, Lu Z, Geurts AM, Usa K, Jacob HJ, Cowley AW, Wang N, Liang M) Kidney Int 2015 Oct;88(4):796-803 PMID: 26108065 PMCID: PMC4589441 SCOPUS ID: 2-s2.0-84942983545 06/25/2015       61 Citations
  • B-Type Natriuretic Peptide Deletion Leads to Progressive Hypertension, Associated Organ Damage, and Reduced Survival: Novel Model for Human Hypertension. (Holditch SJ, Schreiber CA, Nini R, Tonne JM, Peng KW, Geurts A, Jacob HJ, Burnett JC, Cataliotti A, Ikeda Y) Hypertension 2015 Jul;66(1):199-210 PMID: 26063669 PMCID: PMC4467451 SCOPUS ID: 2-s2.0-84941598794 06/13/2015       47 Citations
  • 2015 Guidelines for Establishing Genetically Modified Rat Models for Cardiovascular Research. (Flister MJ, Prokop JW, Lazar J, Shimoyama M, Dwinell M, Geurts A, International Committee on Standardized Genetic Nomenclature for Mice, Rat Genome and Nomenclature Committee) J Cardiovasc Transl Res 2015 Jun;8(4):269-77 PMID: 25920443 PMCID: PMC4475456 SCOPUS ID: 2-s2.0-84931568348 04/30/2015       22 Citations
  • Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease. (Qin W, Dion SL, Kutny PM, Zhang Y, Cheng AW, Jillette NL, Malhotra A, Geurts AM, Chen YG, Wang H) Genetics 2015 Jun;200(2):423-30 PMID: 25819794 PMCID: PMC4492369 SCOPUS ID: 2-s2.0-84931385060 03/31/2015       202 Citations
  • Mutation of SH2B3 (LNK), a genome-wide association study candidate for hypertension, attenuates Dahl salt-sensitive hypertension via inflammatory modulation. (Rudemiller NP, Lund H, Priestley JR, Endres BT, Prokop JW, Jacob HJ, Geurts AM, Cohen EP, Mattson DL) Hypertension 2015 May;65(5):1111-7 PMID: 25776069 PMCID: PMC4412596 SCOPUS ID: 2-s2.0-84937509309 03/18/2015       55 Citations
  • SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis. (Flister MJ, Hoffman MJ, Lemke A, Prisco SZ, Rudemiller N, O'Meara CC, Tsaih SW, Moreno C, Geurts AM, Lazar J, Adhikari N, Hall JL, Jacob HJ) Circ Cardiovasc Genet 2015 Apr;8(2):294-304 PMID: 25628389 SCOPUS ID: 2-s2.0-84942919523 01/30/2015       21 Citations
  • Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat. (Fan F, Geurts AM, Murphy SR, Pabbidi MR, Jacob HJ, Roman RJ) Am J Physiol Regul Integr Comp Physiol 2015 Mar 01;308(5):R379-90 PMID: 25540098 PMCID: PMC4346760 SCOPUS ID: 2-s2.0-84923860726 12/30/2014       43 Citations
  • Targeted disruption of Tbc1d20 with zinc-finger nucleases causes cataracts and testicular abnormalities in mice. (Park AK, Liegel RP, Ronchetti A, Ebert AD, Geurts A, Sidjanin DJ) BMC Genet 2014 Dec 05;15:135 PMID: 25476608 PMCID: PMC4266191 SCOPUS ID: 2-s2.0-84964313193 12/06/2014       17 Citations
  • Maternal diet during gestation and lactation modifies the severity of salt-induced hypertension and renal injury in Dahl salt-sensitive rats. (Geurts AM, Mattson DL, Liu P, Cabacungan E, Skelton MM, Kurth TM, Yang C, Endres BT, Klotz J, Liang M, Cowley AW Jr) Hypertension 2015 Feb;65(2):447-55 PMID: 25452472 PMCID: PMC4289102 SCOPUS ID: 2-s2.0-84921562280 12/03/2014       56 Citations
  • Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats. (Fan F, Geurts AM, Pabbidi MR, Smith SV, Harder DR, Jacob H, Roman RJ) PLoS One 2014;9(11):e112878 PMID: 25397684 PMCID: PMC4232417 SCOPUS ID: 2-s2.0-84911866190 11/15/2014       31 Citations
  • CXM: a new tool for mapping breast cancer risk in the tumor microenvironment. (Flister MJ, Endres BT, Rudemiller N, Sarkis AB, Santarriaga S, Roy I, Lemke A, Geurts AM, Moreno C, Ran S, Tsaih SW, De Pons J, Carlson DF, Tan W, Fahrenkrug SC, Lazarova Z, Lazar J, North PE, LaViolette PS, Dwinell MB, Shull JD, Jacob HJ) Cancer Res 2014 Nov 15;74(22):6419-29 PMID: 25172839 PMCID: PMC4247541 SCOPUS ID: 2-s2.0-84918497707 08/31/2014       25 Citations
  • Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat. (Endres BT, Priestley JR, Palygin O, Flister MJ, Hoffman MJ, Weinberg BD, Grzybowski M, Lombard JH, Staruschenko A, Moreno C, Jacob HJ, Geurts AM) Proc Natl Acad Sci U S A 2014 Sep 02;111(35):12817-22 PMID: 25136115 PMCID: PMC4156702 SCOPUS ID: 2-s2.0-84907228029 08/20/2014       48 Citations
  • HV1 acts as a sodium sensor and promotes superoxide production in medullary thick ascending limb of Dahl salt-sensitive rats. (Jin C, Sun J, Stilphen CA, Smith SM, Ocasio H, Bermingham B, Darji S, Guha A, Patel R, Geurts AM, Jacob HJ, Lambert NA, O'Connor PM) Hypertension 2014 Sep;64(3):541-50 PMID: 24935944 PMCID: PMC4324599 SCOPUS ID: 2-s2.0-84907598794 06/18/2014       18 Citations
  • Germline transgenesis in pigs by cytoplasmic microinjection of Sleeping Beauty transposons. (Ivics Z, Garrels W, Mátés L, Yau TY, Bashir S, Zidek V, Landa V, Geurts A, Pravenec M, Rülicke T, Kues WA, Izsvák Z) Nat Protoc 2014 Apr;9(4):810-27 PMID: 24625780 SCOPUS ID: 2-s2.0-84897143787 03/15/2014       63 Citations
  • Germline transgenesis in rabbits by pronuclear microinjection of Sleeping Beauty transposons. (Ivics Z, Hiripi L, Hoffmann OI, Mátés L, Yau TY, Bashir S, Zidek V, Landa V, Geurts A, Pravenec M, Rülicke T, Bösze Z, Izsvák Z) Nat Protoc 2014 Apr;9(4):794-809 PMID: 24625779 SCOPUS ID: 2-s2.0-84897143633 03/15/2014       49 Citations
  • Germline transgenesis in rodents by pronuclear microinjection of Sleeping Beauty transposons. (Ivics Z, Mátés L, Yau TY, Landa V, Zidek V, Bashir S, Hoffmann OI, Hiripi L, Garrels W, Kues WA, Bösze Z, Geurts A, Pravenec M, Rülicke T, Izsvák Z) Nat Protoc 2014 Apr;9(4):773-93 PMID: 24625778 SCOPUS ID: 2-s2.0-84897127002 03/15/2014       55 Citations
  • CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney. (Rudemiller N, Lund H, Jacob HJ, Geurts AM, Mattson DL, PhysGen Knockout Program) Hypertension 2014 Mar;63(3):559-64 PMID: 24343121 PMCID: PMC3945169 SCOPUS ID: 2-s2.0-84894492650 12/18/2013       113 Citations
  • Amelioration of salt-induced vascular dysfunction in mesenteric arteries of Dahl salt-sensitive rats by missense mutation of extracellular superoxide dismutase. (Beyer AM, Raffai G, Weinberg BD, Fredrich K, Rodgers MS, Geurts AM, Jacob HJ, Dwinell MR, Lombard JH) Am J Physiol Heart Circ Physiol 2014 Feb;306(3):H339-47 PMID: 24322611 PMCID: PMC3920146 SCOPUS ID: 2-s2.0-84893409421 12/11/2013       11 Citations
  • Retraction of "Derivation and genetic modification of embryonic stem cells from disease-model inbred rat strains". Stem Cells Dev 2013 Oct 15;22(20):2813 PMID: 24083560 SCOPUS ID: 2-s2.0-84885161462 10/03/2013    
  • Identifying multiple causative genes at a single GWAS locus. (Flister MJ, Tsaih SW, O'Meara CC, Endres B, Hoffman MJ, Geurts AM, Dwinell MR, Lazar J, Jacob HJ, Moreno C) Genome Res 2013 Dec;23(12):1996-2002 PMID: 24006081 PMCID: PMC3847770 SCOPUS ID: 2-s2.0-84888132259 09/06/2013       86 Citations
  • Gene targeting in NOD mouse embryos using zinc-finger nucleases. (Chen YG, Forsberg MH, Khaja S, Ciecko AE, Hessner MJ, Geurts AM) Diabetes 2014 Jan;63(1):68-74 PMID: 23974926 PMCID: PMC3868049 SCOPUS ID: 2-s2.0-84891791730 08/27/2013       23 Citations
  • Rats are the smart choice: Rationale for a renewed focus on rats in behavioral genetics. (Parker CC, Chen H, Flagel SB, Geurts AM, Richards JB, Robinson TE, Solberg Woods LC, Palmer AA) Neuropharmacology 2014 Jan;76 Pt B(0 0):250-8 PMID: 23791960 PMCID: PMC3823679 SCOPUS ID: 2-s2.0-84887068500 06/25/2013       63 Citations
  • Genetic mutation of recombination activating gene 1 in Dahl salt-sensitive rats attenuates hypertension and renal damage. (Mattson DL, Lund H, Guo C, Rudemiller N, Geurts AM, Jacob H) Am J Physiol Regul Integr Comp Physiol 2013 Mar 15;304(6):R407-14 PMID: 23364523 PMCID: PMC3602820 SCOPUS ID: 2-s2.0-84877109327 02/01/2013       142 Citations
  • Rab38 modulates proteinuria in model of hypertension-associated renal disease. (Rangel-Filho A, Lazar J, Moreno C, Geurts A, Jacob HJ) J Am Soc Nephrol 2013 Feb;24(2):283-92 PMID: 23291471 PMCID: PMC3559491 SCOPUS ID: 2-s2.0-84873357210 01/08/2013       36 Citations
  • Heterozygous knockout of transforming growth factor-β1 protects Dahl S rats against high salt-induced renal injury. (Chen CC, Geurts AM, Jacob HJ, Fan F, Roman RJ) Physiol Genomics 2013 Feb 04;45(3):110-8 PMID: 23249995 PMCID: PMC3568879 SCOPUS ID: 2-s2.0-84873418766 12/20/2012       18 Citations
  • Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits. (Katter K, Geurts AM, Hoffmann O, Mátés L, Landa V, Hiripi L, Moreno C, Lazar J, Bashir S, Zidek V, Popova E, Jerchow B, Becker K, Devaraj A, Walter I, Grzybowksi M, Corbett M, Filho AR, Hodges MR, Bader M, Ivics Z, Jacob HJ, Pravenec M, Bosze Z, Rülicke T, Izsvák Z) FASEB J 2013 Mar;27(3):930-41 PMID: 23195032 PMCID: PMC3574282 SCOPUS ID: 2-s2.0-84874610564 12/01/2012       79 Citations
  • High-throughput phenotyping of avoidance learning in mice discriminates different genotypes and identifies a novel gene. (Maroteaux G, Loos M, van der Sluis S, Koopmans B, Aarts E, van Gassen K, Geurts A, NeuroBSIK Mouse Phenomics Consortium, Largaespada DA, Spruijt BM, Stiedl O, Smit AB, Verhage M) Genes Brain Behav 2012 Oct;11(7):772-84 PMID: 22846151 PMCID: PMC3508728 SCOPUS ID: 2-s2.0-84867336581 08/01/2012       45 Citations
  • Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension. (Feng D, Yang C, Geurts AM, Kurth T, Liang M, Lazar J, Mattson DL, O'Connor PM, Cowley AW Jr) Cell Metab 2012 Feb 08;15(2):201-8 PMID: 22326221 PMCID: PMC3280886 SCOPUS ID: 2-s2.0-84863012892 02/14/2012       118 Citations
  • Efficient non-viral integration and stable gene expression in multipotent adult progenitor cells. (Wilber A, Ulloa Montoya F, Hammer L, Moriarity BS, Geurts AM, Largaespada DA, Verfaillie CM, McIvor RS, Lakshmipathy U) Stem Cells Int 2011;2011:717069 PMID: 21977042 PMCID: PMC3184415 SCOPUS ID: 2-s2.0-84855259897 10/07/2011       7 Citations
  • The emerging role for rat models in gene discovery. (Dwinell MR, Lazar J, Geurts AM) Mamm Genome 2011 Aug;22(7-8):466-75 PMID: 21732192 PMCID: PMC3643810 SCOPUS ID: 2-s2.0-80051552900 07/07/2011       23 Citations
  • Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase. (Xu D, Guo H, Xu X, Lu Z, Fassett J, Hu X, Xu Y, Tang Q, Hu D, Somani A, Geurts AM, Ostertag E, Bache RJ, Weir EK, Chen Y) Hypertension 2011 Aug;58(2):303-9 PMID: 21730301 PMCID: PMC3170043 SCOPUS ID: 2-s2.0-80051473132 07/07/2011       62 Citations
  • Creation and characterization of a renin knockout rat. (Moreno C, Hoffman M, Stodola TJ, Didier DN, Lazar J, Geurts AM, North PE, Jacob HJ, Greene AS) Hypertension 2011 Mar;57(3):614-9 PMID: 21242461 PMCID: PMC3513323 SCOPUS ID: 2-s2.0-79953224403 01/19/2011       57 Citations
  • Disruption of the neuregulin 1 gene in the rat alters HPA axis activity and behavioral responses to environmental stimuli. (Taylor SB, Taylor AR, Markham JA, Geurts AM, Kanaskie BZ, Koenig JI) Physiol Behav 2011 Aug 03;104(2):205-14 PMID: 21092742 PMCID: PMC3081908 SCOPUS ID: 2-s2.0-79958799340 11/26/2010       32 Citations
  • Gene targeting in the rat: advances and opportunities. (Jacob HJ, Lazar J, Dwinell MR, Moreno C, Geurts AM) Trends Genet 2010 Dec;26(12):510-8 PMID: 20869786 PMCID: PMC2991520 SCOPUS ID: 2-s2.0-78549295495 09/28/2010       86 Citations
  • Zinc-finger nucleases: new strategies to target the rat genome. (Geurts AM, Moreno C) Clin Sci (Lond) 2010 Jul 06;119(8):303-11 PMID: 20615201 PMCID: PMC3549593 SCOPUS ID: 2-s2.0-77956367668 07/10/2010       34 Citations
  • Efficient mammalian germline transgenesis by cis-enhanced Sleeping Beauty transposition. (Carlson DF, Geurts AM, Garbe JR, Park CW, Rangel-Filho A, O'Grady SM, Jacob HJ, Steer CJ, Largaespada DA, Fahrenkrug SC) Transgenic Res 2011 Feb;20(1):29-45 PMID: 20352328 PMCID: PMC3516389 SCOPUS ID: 2-s2.0-78651398529 03/31/2010       25 Citations
  • Generation of gene-specific mutated rats using zinc-finger nucleases. (Geurts AM, Cost GJ, Rémy S, Cui X, Tesson L, Usal C, Ménoret S, Jacob HJ, Anegon I, Buelow R) Methods Mol Biol 2010;597:211-25 PMID: 20013236 SCOPUS ID: 2-s2.0-77449157725 12/17/2009       92 Citations
  • Knockout rats via embryo microinjection of zinc-finger nucleases. (Geurts AM, Cost GJ, Freyvert Y, Zeitler B, Miller JC, Choi VM, Jenkins SS, Wood A, Cui X, Meng X, Vincent A, Lam S, Michalkiewicz M, Schilling R, Foeckler J, Kalloway S, Weiler H, Ménoret S, Anegon I, Davis GD, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Jacob HJ, Buelow R) Science 2009 Jul 24;325(5939):433 PMID: 19628861 PMCID: PMC2831805 SCOPUS ID: 2-s2.0-67749106611 07/25/2009       780 Citations
  • Progress and prospects in rat genetics: a community view. (Aitman TJ, Critser JK, Cuppen E, Dominiczak A, Fernandez-Suarez XM, Flint J, Gauguier D, Geurts AM, Gould M, Harris PC, Holmdahl R, Hubner N, Izsvák Z, Jacob HJ, Kuramoto T, Kwitek AE, Marrone A, Mashimo T, Moreno C, Mullins J, Mullins L, Olsson T, Pravenec M, Riley L, Saar K, Serikawa T, Shull JD, Szpirer C, Twigger SN, Voigt B, Worley K) Nat Genet 2008 May;40(5):516-22 PMID: 18443588 SCOPUS ID: 2-s2.0-42649111665 04/30/2008       240 Citations
  • Predicting preferential DNA vector insertion sites: implications for functional genomics and gene therapy. (Hackett CS, Geurts AM, Hackett PB) Genome Biol 2007;8 Suppl 1(Suppl 1):S12 PMID: 18047689 PMCID: PMC2106846 SCOPUS ID: 2-s2.0-38449089316 12/06/2007       51 Citations
  • Generation of rat mutants using a coat color-tagged Sleeping Beauty transposon system. (Lu B, Geurts AM, Poirier C, Petit DC, Harrison W, Overbeek PA, Bishop CE) Mamm Genome 2007 May;18(5):338-46 PMID: 17557177 SCOPUS ID: 2-s2.0-34547102476 06/09/2007       71 Citations
  • Efficient transgenic rat production by a lentiviral vector. (Michalkiewicz M, Michalkiewicz T, Geurts AM, Roman RJ, Slocum GR, Singer O, Weihrauch D, Greene AS, Kaldunski M, Verma IM, Jacob HJ, Cowley AW Jr) Am J Physiol Heart Circ Physiol 2007 Jul;293(1):H881-94 PMID: 17322424 SCOPUS ID: 2-s2.0-34547112080 02/27/2007       36 Citations
  • Harnessing a high cargo-capacity transposon for genetic applications in vertebrates. (Balciunas D, Wangensteen KJ, Wilber A, Bell J, Geurts A, Sivasubbu S, Wang X, Hackett PB, Largaespada DA, McIvor RS, Ekker SC) PLoS Genet 2006 Nov 10;2(11):e169 PMID: 17096595 PMCID: PMC1635535 SCOPUS ID: 2-s2.0-33751352744 11/14/2006       251 Citations
  • Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers. (Geurts AM, Collier LS, Geurts JL, Oseth LL, Bell ML, Mu D, Lucito R, Godbout SA, Green LE, Lowe SW, Hirsch BA, Leinwand LA, Largaespada DA) PLoS Genet 2006 Sep 29;2(9):e156 PMID: 17009875 PMCID: PMC1584263 SCOPUS ID: 2-s2.0-33749416026 10/03/2006       86 Citations
  • Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon. (Geurts AM, Wilber A, Carlson CM, Lobitz PD, Clark KJ, Hackett PB, McIvor RS, Largaespada DA) BMC Biotechnol 2006 Jun 26;6:30 PMID: 16800892 PMCID: PMC1557845 SCOPUS ID: 2-s2.0-33748186110 06/28/2006       35 Citations
  • Structure-based prediction of insertion-site preferences of transposons into chromosomes. (Geurts AM, Hackett CS, Bell JB, Bergemann TL, Collier LS, Carlson CM, Largaespada DA, Hackett PB) Nucleic Acids Res 2006;34(9):2803-11 PMID: 16717285 PMCID: PMC1464413 SCOPUS ID: 2-s2.0-33744827138 05/24/2006       64 Citations
  • Target-site preferences of Sleeping Beauty transposons. (Liu G, Geurts AM, Yae K, Srinivasan AR, Fahrenkrug SC, Largaespada DA, Takeda J, Horie K, Olson WK, Hackett PB) J Mol Biol 2005 Feb 11;346(1):161-73 PMID: 15663935 SCOPUS ID: 2-s2.0-19944431736 01/25/2005       116 Citations
  • Transposon vectors for gene-trap insertional mutagenesis in vertebrates. (Clark KJ, Geurts AM, Bell JB, Hackett PB) Genesis 2004 Aug;39(4):225-33 PMID: 15286994 SCOPUS ID: 2-s2.0-4444339395 08/03/2004       54 Citations
  • Gene transfer into genomes of human cells by the sleeping beauty transposon system. (Geurts AM, Yang Y, Clark KJ, Liu G, Cui Z, Dupuy AJ, Bell JB, Largaespada DA, Hackett PB) Mol Ther 2003 Jul;8(1):108-17 PMID: 12842434 SCOPUS ID: 2-s2.0-0042700227 07/05/2003       303 Citations
  • Structure-function analysis of the inverted terminal repeats of the sleeping beauty transposon. (Cui Z, Geurts AM, Liu G, Kaufman CD, Hackett PB) J Mol Biol 2002 May 17;318(5):1221-35 PMID: 12083513 SCOPUS ID: 2-s2.0-0036317929 06/27/2002       194 Citations
    • Last update: 05/14/2024