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Aron Geurts PhD

Aron Geurts PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Physiology
Program: Genetics

Member of the Cardiovascular Center
Member of the Genomic Sciences and Precision Medicine Center (GSPMC)


I am willing to collaborate on research projects.


Research Experience

  • Animals, Genetically Modified
  • Biotechnology
  • DNA Transposable Elements
  • Genetic Engineering
  • Genetic Research
  • Organisms, Genetically Modified
  • Plasmids
  • Rats
  • Methodologies and Techniques

  • Animals, Genetically Modified
  • Biotechnology
  • Cloning, Molecular
  • Embryonic Stem Cells
  • Genetic Vectors
  • Organisms, Genetically Modified
  • Plasmids
  • Rats, Inbred BN
  • Rats, Inbred Dahl
  • Rats, Inbred Strains
  • Sequence Analysis, DNA
  • MCW Program / Core Facilities

  • Rat Transgenic Core
  • Publications

  • A Hypermorphic Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8 T Cells in NOD Mice. (Presa M, Racine JJ, Dwyer JR, Lamont DJ, Ratiu JJ, Sarsani VK, Chen YG, Geurts A, Schmitz I, Stearns T, Allocco J, Chapman HD, Serreze DV) J Immunol 2018 Oct 01;201(7):1907-1917 PMID: 30127089 PMCID: PMC6143397 08/22/2018    
  • Tissue-specific effects of targeted mutation of Mir29b1 in rats. (Xue H, Zhang G, Geurts AM, Usa K, Jensen DM, Liu Y, Widlansky ME, Liang M) EBioMedicine 2018 Sep;35:260-269 PMID: 30120082 PMCID: PMC6156712 08/19/2018    
  • MicroRNA-214-3p in the Kidney Contributes to the Development of Hypertension. (Liu Y, Usa K, Wang F, Liu P, Geurts AM, Li J, Williams AM, Regner KR, Kong Y, Liu H, Nie J, Liang M) J Am Soc Nephrol 2018 Oct;29(10):2518-2528 PMID: 30049682 PMCID: PMC6171279 07/28/2018       1 Citations
  • Protective role of Trpc6 knockout in the progression of diabetic kidney disease. (Spires D, Ilatovskaya DV, Levchenko V, North PE, Geurts AM, Palygin O, Staruschenko A) Am J Physiol Renal Physiol 2018 Oct 01;315(4):F1091-F1097 PMID: 29923767 PMCID: PMC6230750 06/21/2018    
  • Sdha+/- Rats Display Minimal Muscle Pathology Without Significant Behavioral or Biochemical Abnormalities. (Siebers EM, Choi MJ, Tinklenberg JA, Beatka MJ, Ayres S, Meng H, Helbling DC, Takizawa A, Bennett B, Garces AM, Dias Duarte Machado LG, Dimmock D, Dwinell MR, Geurts AM, Lawlor MW) J Neuropathol Exp Neurol 2018 Aug 01;77(8):665-672 PMID: 29850869 PMCID: PMC6044411 06/01/2018    
  • A NOX4/TRPC6 Pathway in Podocyte Calcium Regulation and Renal Damage in Diabetic Kidney Disease. (Ilatovskaya DV, Blass G, Palygin O, Levchenko V, Pavlov TS, Grzybowski MN, Winsor K, Shuyskiy LS, Geurts AM, Cowley AW Jr, Birnbaumer L, Staruschenko A) J Am Soc Nephrol 2018 Jul;29(7):1917-1927 PMID: 29793963 PMCID: PMC6050934 05/26/2018    
  • Genome-wide map of proximity linkage to renin proximal promoter in rat. (Stodola TJ, Liu P, Liu Y, Vallejos AK, Geurts AM, Greene AS, Liang M) Physiol Genomics 2018 May 01;50(5):323-331 PMID: 29521603 PMCID: PMC6008118 03/10/2018    
  • Characterization of Coding/Noncoding Variants for in Patients with CKD. (Prokop JW, Yeo NC, Ottmann C, Chhetri SB, Florus KL, Ross EJ, Sosonkina N, Link BA, Freedman BI, Coppola CJ, McDermott-Roe C, Leysen S, Milroy LG, Meijer FA, Geurts AM, Rauscher FJ 3rd, Ramaker R, Flister MJ, Jacob HJ, Mendenhall EM, Lazar J) J Am Soc Nephrol 2018 May;29(5):1525-1535 PMID: 29476007 PMCID: PMC5967772 02/25/2018    
  • miR-29 contributes to normal endothelial function and can restore it in cardiometabolic disorders. (Widlansky ME, Jensen DM, Wang J, Liu Y, Geurts AM, Kriegel AJ, Liu P, Ying R, Zhang G, Casati M, Chu C, Malik M, Branum A, Tanner MJ, Tyagi S, Usa K, Liang M) EMBO Mol Med 2018 03;10(3) PMID: 29374012 PMCID: PMC5840545 01/28/2018       7 Citations
  • Keratinocytes mediate innocuous and noxious touch via ATP-P2X4 signaling. (Moehring F, Cowie AM, Menzel AD, Weyer AD, Grzybowski M, Arzua T, Geurts AM, Palygin O, Stucky CL) Elife 2018 01 16;7 PMID: 29336303 PMCID: PMC5777822 01/18/2018       9 Citations
  • Determination of total plasma oxysterols by enzymatic hydrolysis, solid phase extraction and liquid chromatography coupled to mass-spectrometry. (Mendiara I, Domeño C, Nerín C, Geurts AM, Osada J, Martínez-Beamonte R) J Pharm Biomed Anal 2018 Feb 20;150:396-405 PMID: 29288965 12/31/2017       1 Citations
  • Evaluation of Vascular Control Mechanisms Utilizing Video Microscopy of Isolated Resistance Arteries of Rats. (Lukaszewicz KM, Durand MJ, Priestley JRC, Schmidt JR, Allen LA, Geurts AM, Lombard JH) J Vis Exp 2017 12 05(130) PMID: 29286398 PMCID: PMC5755532 12/30/2017    
  • Nitric oxide production by glomerular podocytes. (Palygin O, Ilatovskaya DV, Levchenko V, Endres BT, Geurts AM, Staruschenko A) Nitric Oxide 2018 Jan 30;72:24-31 PMID: 29128399 PMCID: PMC5776695 11/13/2017    
  • In vitro characterization of mitochondrial function and structure in rat and human cells with a deficiency of the NADH: ubiquinone oxidoreductase Ndufc2 subunit. (Raffa S, Scrofani C, Valente S, Micaloni A, Forte M, Bianchi F, Coluccia R, Geurts AM, Sciarretta S, Volpe M, Torrisi MR, Rubattu S) Hum Mol Genet 2017 12 01;26(23):4541-4555 PMID: 28973657 PMCID: PMC5886163 10/04/2017       3 Citations
  • Essential role of Kir5.1 channels in renal salt handling and blood pressure control. (Palygin O, Levchenko V, Ilatovskaya DV, Pavlov TS, Pochynyuk OM, Jacob HJ, Geurts AM, Hodges MR, Staruschenko A) JCI Insight 2017 Sep 21;2(18) PMID: 28931751 PMCID: PMC5621918 09/22/2017    
  • Active sleep unmasks apnea and delayed arousal in infant rat pups lacking central serotonin. (Young JO, Geurts A, Hodges MR, Cummings KJ) J Appl Physiol (1985) 2017 Oct 01;123(4):825-834 PMID: 28775068 PMCID: PMC5668447 08/05/2017       2 Citations
  • Elevation of fumarase attenuates hypertension and can result from a nonsynonymous sequence variation or increased expression depending on rat strain. (Usa K, Liu Y, Geurts AM, Cheng Y, Lazar J, Baker MA, Grzybowski M, He Y, Tian Z, Liang M) Physiol Genomics 2017 Sep 01;49(9):496-504 PMID: 28754823 PMCID: PMC5625267 07/30/2017       4 Citations
  • Host genetic modifiers of nonproductive angiogenesis inhibit breast cancer. (Flister MJ, Tsaih SW, Stoddard A, Plasterer C, Jagtap J, Parchur AK, Sharma G, Prisco AR, Lemke A, Murphy D, Al-Gizawiy M, Straza M, Ran S, Geurts AM, Dwinell MR, Greene AS, Bergom C, LaViolette PS, Joshi A) Breast Cancer Res Treat 2017 Aug;165(1):53-64 PMID: 28567545 06/02/2017       2 Citations
  • Intravital imaging of the kidney in a rat model of salt-sensitive hypertension. (Endres BT, Sandoval RM, Rhodes GJ, Campos-Bilderback SB, Kamocka MM, McDermott-Roe C, Staruschenko A, Molitoris BA, Geurts AM, Palygin O) Am J Physiol Renal Physiol 2017 Aug 01;313(2):F163-F173 PMID: 28404591 PMCID: PMC5582897 04/14/2017       4 Citations
  • Lung injury pathways: Adenosine receptor 2B signaling limits development of ischemic bronchiolitis obliterans organizing pneumonia. (Densmore JC, Schaid TR, Jeziorczak PM, Medhora M, Audi S, Nayak S, Auchampach J, Dwinell MR, Geurts AM, Jacobs ER) Exp Lung Res 2017 02;43(1):38-48 PMID: 28266889 PMCID: PMC5831175 03/08/2017       3 Citations
  • Efficient Precision Genome Editing in iPSCs via Genetic Co-targeting with Selection. (Mitzelfelt KA, McDermott-Roe C, Grzybowski MN, Marquez M, Kuo CT, Riedel M, Lai S, Choi MJ, Kolander KD, Helbling D, Dimmock DP, Battle MA, Jou CJ, Tristani-Firouzi M, Verbsky JW, Benjamin IJ, Geurts AM) Stem Cell Reports 2017 03 14;8(3):491-499 PMID: 28238794 PMCID: PMC5355643 02/28/2017       8 Citations
  • Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function. (McDermott-Roe C, Leleu M, Rowe GC, Palygin O, Bukowy JD, Kuo J, Rech M, Hermans-Beijnsberger S, Schaefer S, Adami E, Creemers EE, Heinig M, Schroen B, Arany Z, Petretto E, Geurts AM) PLoS One 2017;12(2):e0170458 PMID: 28158196 PMCID: PMC5291451 02/06/2017       2 Citations
  • ISH ADA-01 Critical role of telomerase in regulating cerebral vascular function and redox environment. (Ait-Aissa K, Hockenberry J, Gutterman D, Geurts A, Beyer A) J Hypertens 2016 Sep;34 Suppl 1 - ISH 2016 Abstract Book:e39 PMID: 27753880 10/19/2016    
  • A RATional choice for translational research? (Aitman T, Dhillon P, Geurts AM) Dis Model Mech 2016 10 01;9(10):1069-1072 PMID: 27736742 PMCID: PMC5087836 10/14/2016       15 Citations
  • ISH ADA-01 Critical role of telomerase in regulating cerebral vascular function and redox environment. (Ait-Aissa K, Hockenberry J, Gutterman D, Geurts A, Beyer A) J Hypertens 2016 Sep;34 Suppl 1:e39 PMID: 27643173 09/20/2016    
  • Early development of podocyte injury independently of hyperglycemia and elevations in arterial pressure in nondiabetic obese Dahl SS leptin receptor mutant rats. (McPherson KC, Taylor L, Johnson AC, Didion SP, Geurts AM, Garrett MR, Williams JM) Am J Physiol Renal Physiol 2016 10 01;311(4):F793-F804 PMID: 27465994 PMCID: PMC5142236 07/29/2016    
  • Gene Editing: Practical Application in the Lab. (Geurts AM, Ekker SC) Hum Gene Ther 2016 06;27(6):417-8 PMID: 27322167 PMCID: PMC5583549 06/21/2016       1 Citations
  • p66Shc regulates renal vascular tone in hypertension-induced nephropathy. (Miller B, Palygin O, Rufanova VA, Chong A, Lazar J, Jacob HJ, Mattson D, Roman RJ, Williams JM, Cowley AW Jr, Geurts AM, Staruschenko A, Imig JD, Sorokin A) J Clin Invest 2016 07 01;126(7):2533-46 PMID: 27270176 PMCID: PMC4922697 06/09/2016       6 Citations
  • The Human 343delT HSPB5 Chaperone Associated with Early-onset Skeletal Myopathy Causes Defects in Protein Solubility. (Mitzelfelt KA, Limphong P, Choi MJ, Kondrat FD, Lai S, Kolander KD, Kwok WM, Dai Q, Grzybowski MN, Zhang H, Taylor GM, Lui Q, Thao MT, Hudson JA, Barresi R, Bushby K, Jungbluth H, Wraige E, Geurts AM, Benesch JL, Riedel M, Christians ES, Minella AC, Benjamin IJ) J Biol Chem 2016 07 15;291(29):14939-53 PMID: 27226619 PMCID: PMC4946913 05/27/2016       4 Citations
  • Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure. (Kuijk EW, Rasmussen S, Blokzijl F, Huch M, Gehart H, Toonen P, Begthel H, Clevers H, Geurts AM, Cuppen E) Sci Rep 2016 Feb 26;6:22154 PMID: 26915950 PMCID: PMC4768167 02/27/2016       14 Citations
  • Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease. (Rubattu S, Di Castro S, Schulz H, Geurts AM, Cotugno M, Bianchi F, Maatz H, Hummel O, Falak S, Stanzione R, Marchitti S, Scarpino S, Giusti B, Kura A, Gensini GF, Peyvandi F, Mannucci PM, Rasura M, Sciarretta S, Dwinell MR, Hubner N, Volpe M) J Am Heart Assoc 2016 Feb 17;5(2) PMID: 26888427 PMCID: PMC4802485 02/19/2016    
  • Chronic central serotonin depletion attenuates ventilation and body temperature in young but not adult Tph2 knockout rats. (Kaplan K, Echert AE, Massat B, Puissant MM, Palygin O, Geurts AM, Hodges MR) J Appl Physiol (1985) 2016 05 01;120(9):1070-81 PMID: 26869713 PMCID: PMC4855209 02/13/2016       5 Citations
  • Potentially diagnostic electron paramagnetic resonance spectra elucidate the underlying mechanism of mitochondrial dysfunction in the deoxyguanosine kinase deficient rat model of a genetic mitochondrial DNA depletion syndrome. (Bennett B, Helbling D, Meng H, Jarzembowski J, Geurts AM, Friederich MW, Van Hove JLK, Lawlor MW, Dimmock DP) Free Radic Biol Med 2016 Mar;92:141-151 PMID: 26773591 PMCID: PMC5047058 01/17/2016       7 Citations
  • Evidence of the Importance of Nox4 in Production of Hypertension in Dahl Salt-Sensitive Rats. (Cowley AW Jr, Yang C, Zheleznova NN, Staruschenko A, Kurth T, Rein L, Kumar V, Sadovnikov K, Dayton A, Hoffman M, Ryan RP, Skelton MM, Salehpour F, Ranji M, Geurts A) Hypertension 2016 Feb;67(2):440-50 PMID: 26644237 PMCID: PMC4713301 12/09/2015       25 Citations
  • The NRF2 knockout rat: a new animal model to study endothelial dysfunction, oxidant stress, and microvascular rarefaction. (Priestley JR, Kautenburg KE, Casati MC, Endres BT, Geurts AM, Lombard JH) Am J Physiol Heart Circ Physiol 2016 Feb 15;310(4):H478-87 PMID: 26637559 PMCID: PMC4796617 12/08/2015       12 Citations
  • Pappa2 is linked to salt-sensitive hypertension in Dahl S rats. (Cowley AW Jr, Yang C, Kumar V, Lazar J, Jacob H, Geurts AM, Liu P, Dayton A, Kurth T, Liang M) Physiol Genomics 2016 Jan;48(1):62-72 PMID: 26534937 PMCID: PMC4757026 11/05/2015       10 Citations
  • Expression and function of the Scn5a-encoded voltage-gated sodium channel NaV 1.5 in the rat jejunum. (Beyder A, Gibbons SJ, Mazzone A, Strege PR, Saravanaperumal SA, Sha L, Higgins S, Eisenman ST, Bernard CE, Geurts A, Kline CF, Mohler PJ, Farrugia G) Neurogastroenterol Motil 2016 Jan;28(1):64-73 PMID: 26459913 PMCID: PMC4688076 10/16/2015       4 Citations
  • Myosin Id is required for planar cell polarity in ciliated tracheal and ependymal epithelial cells. (Hegan PS, Ostertag E, Geurts AM, Mooseker MS) Cytoskeleton (Hoboken) 2015 Oct;72(10):503-16 PMID: 26446290 PMCID: PMC4715625 10/09/2015       12 Citations
  • Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension. (Nayak S, Khan MA, Wan TC, Pei H, Linden J, Dwinell MR, Geurts AM, Imig JD, Auchampach JA) Purinergic Signal 2015 Dec;11(4):519-31 PMID: 26385692 PMCID: PMC4648794 09/20/2015       5 Citations
  • Two-photon Imaging of Intracellular Ca2+ Handling and Nitric Oxide Production in Endothelial and Smooth Muscle Cells of an Isolated Rat Aorta. (Endres BT, Staruschenko A, Schulte M, Geurts AM, Palygin O) J Vis Exp 2015 Jun 10(100):e52734 PMID: 26132549 PMCID: PMC4545029 07/02/2015       1 Citations
  • Antithrombin III/SerpinC1 insufficiency exacerbates renal ischemia/reperfusion injury. (Wang F, Zhang G, Lu Z, Geurts AM, Usa K, Jacob HJ, Cowley AW, Wang N, Liang M) Kidney Int 2015 Oct;88(4):796-803 PMID: 26108065 PMCID: PMC4589441 06/25/2015       33 Citations
  • B-Type Natriuretic Peptide Deletion Leads to Progressive Hypertension, Associated Organ Damage, and Reduced Survival: Novel Model for Human Hypertension. (Holditch SJ, Schreiber CA, Nini R, Tonne JM, Peng KW, Geurts A, Jacob HJ, Burnett JC, Cataliotti A, Ikeda Y) Hypertension 2015 Jul;66(1):199-210 PMID: 26063669 PMCID: PMC4467451 06/13/2015       19 Citations
  • 2015 Guidelines for Establishing Genetically Modified Rat Models for Cardiovascular Research. (Flister MJ, Prokop JW, Lazar J, Shimoyama M, Dwinell M, Geurts A, International Committee on Standardized Genetic Nomenclature for Mice, Rat Genome and Nomenclature Committee) J Cardiovasc Transl Res 2015 Jun;8(4):269-77 PMID: 25920443 PMCID: PMC4475456 04/30/2015       8 Citations
  • Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease. (Qin W, Dion SL, Kutny PM, Zhang Y, Cheng AW, Jillette NL, Malhotra A, Geurts AM, Chen YG, Wang H) Genetics 2015 Jun;200(2):423-30 PMID: 25819794 PMCID: PMC4492369 03/31/2015       71 Citations
  • Mutation of SH2B3 (LNK), a genome-wide association study candidate for hypertension, attenuates Dahl salt-sensitive hypertension via inflammatory modulation. (Rudemiller NP, Lund H, Priestley JR, Endres BT, Prokop JW, Jacob HJ, Geurts AM, Cohen EP, Mattson DL) Hypertension 2015 May;65(5):1111-7 PMID: 25776069 PMCID: PMC4412596 03/18/2015       25 Citations
  • SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis. (Flister MJ, Hoffman MJ, Lemke A, Prisco SZ, Rudemiller N, O'Meara CC, Tsaih SW, Moreno C, Geurts AM, Lazar J, Adhikari N, Hall JL, Jacob HJ) Circ Cardiovasc Genet 2015 Apr;8(2):294-304 PMID: 25628389 01/30/2015       6 Citations
  • Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat. (Fan F, Geurts AM, Murphy SR, Pabbidi MR, Jacob HJ, Roman RJ) Am J Physiol Regul Integr Comp Physiol 2015 Mar 01;308(5):R379-90 PMID: 25540098 PMCID: PMC4346760 12/30/2014       13 Citations
  • Targeted disruption of Tbc1d20 with zinc-finger nucleases causes cataracts and testicular abnormalities in mice. (Park AK, Liegel RP, Ronchetti A, Ebert AD, Geurts A, Sidjanin DJ) BMC Genet 2014 Dec 05;15:135 PMID: 25476608 PMCID: PMC4266191 12/06/2014       8 Citations
  • Maternal diet during gestation and lactation modifies the severity of salt-induced hypertension and renal injury in Dahl salt-sensitive rats. (Geurts AM, Mattson DL, Liu P, Cabacungan E, Skelton MM, Kurth TM, Yang C, Endres BT, Klotz J, Liang M, Cowley AW Jr) Hypertension 2015 Feb;65(2):447-55 PMID: 25452472 PMCID: PMC4289102 12/03/2014       22 Citations
  • Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats. (Fan F, Geurts AM, Pabbidi MR, Smith SV, Harder DR, Jacob H, Roman RJ) PLoS One 2014;9(11):e112878 PMID: 25397684 PMCID: PMC4232417 11/15/2014       12 Citations
  • CXM: a new tool for mapping breast cancer risk in the tumor microenvironment. (Flister MJ, Endres BT, Rudemiller N, Sarkis AB, Santarriaga S, Roy I, Lemke A, Geurts AM, Moreno C, Ran S, Tsaih SW, De Pons J, Carlson DF, Tan W, Fahrenkrug SC, Lazarova Z, Lazar J, North PE, LaViolette PS, Dwinell MB, Shull JD, Jacob HJ) Cancer Res 2014 Nov 15;74(22):6419-29 PMID: 25172839 PMCID: PMC4247541 08/31/2014       8 Citations
  • Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat. (Endres BT, Priestley JR, Palygin O, Flister MJ, Hoffman MJ, Weinberg BD, Grzybowski M, Lombard JH, Staruschenko A, Moreno C, Jacob HJ, Geurts AM) Proc Natl Acad Sci U S A 2014 Sep 02;111(35):12817-22 PMID: 25136115 PMCID: PMC4156702 08/20/2014       24 Citations
  • HV1 acts as a sodium sensor and promotes superoxide production in medullary thick ascending limb of Dahl salt-sensitive rats. (Jin C, Sun J, Stilphen CA, Smith SM, Ocasio H, Bermingham B, Darji S, Guha A, Patel R, Geurts AM, Jacob HJ, Lambert NA, O'Connor PM) Hypertension 2014 Sep;64(3):541-50 PMID: 24935944 PMCID: PMC4324599 06/18/2014       11 Citations
  • Germline transgenesis in rodents by pronuclear microinjection of Sleeping Beauty transposons. (Ivics Z, Mátés L, Yau TY, Landa V, Zidek V, Bashir S, Hoffmann OI, Hiripi L, Garrels W, Kues WA, Bösze Z, Geurts A, Pravenec M, Rülicke T, Izsvák Z) Nat Protoc 2014 Apr;9(4):773-93 PMID: 24625778 03/15/2014       33 Citations
  • Germline transgenesis in rabbits by pronuclear microinjection of Sleeping Beauty transposons. (Ivics Z, Hiripi L, Hoffmann OI, Mátés L, Yau TY, Bashir S, Zidek V, Landa V, Geurts A, Pravenec M, Rülicke T, Bösze Z, Izsvák Z) Nat Protoc 2014 Apr;9(4):794-809 PMID: 24625779 03/15/2014       27 Citations
  • Germline transgenesis in pigs by cytoplasmic microinjection of Sleeping Beauty transposons. (Ivics Z, Garrels W, Mátés L, Yau TY, Bashir S, Zidek V, Landa V, Geurts A, Pravenec M, Rülicke T, Kues WA, Izsvák Z) Nat Protoc 2014 Apr;9(4):810-27 PMID: 24625780 03/15/2014       44 Citations
  • CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney. (Rudemiller N, Lund H, Jacob HJ, Geurts AM, Mattson DL, PhysGen Knockout Program) Hypertension 2014 Mar;63(3):559-64 PMID: 24343121 PMCID: PMC3945169 12/18/2013       50 Citations
  • Amelioration of salt-induced vascular dysfunction in mesenteric arteries of Dahl salt-sensitive rats by missense mutation of extracellular superoxide dismutase. (Beyer AM, Raffai G, Weinberg BD, Fredrich K, Rodgers MS, Geurts AM, Jacob HJ, Dwinell MR, Lombard JH) Am J Physiol Heart Circ Physiol 2014 Feb;306(3):H339-47 PMID: 24322611 PMCID: PMC3920146 12/11/2013       4 Citations
  • Identifying multiple causative genes at a single GWAS locus. (Flister MJ, Tsaih SW, O'Meara CC, Endres B, Hoffman MJ, Geurts AM, Dwinell MR, Lazar J, Jacob HJ, Moreno C) Genome Res 2013 Dec;23(12):1996-2002 PMID: 24006081 PMCID: PMC3847770 09/06/2013       47 Citations
  • Gene targeting in NOD mouse embryos using zinc-finger nucleases. (Chen YG, Forsberg MH, Khaja S, Ciecko AE, Hessner MJ, Geurts AM) Diabetes 2014 Jan;63(1):68-74 PMID: 23974926 PMCID: PMC3868049 08/27/2013    
  • Rats are the smart choice: Rationale for a renewed focus on rats in behavioral genetics. (Parker CC, Chen H, Flagel SB, Geurts AM, Richards JB, Robinson TE, Solberg Woods LC, Palmer AA) Neuropharmacology 2014 Jan;76 Pt B:250-8 PMID: 23791960 PMCID: PMC3823679 06/25/2013       27 Citations
  • Genetic mutation of recombination activating gene 1 in Dahl salt-sensitive rats attenuates hypertension and renal damage. (Mattson DL, Lund H, Guo C, Rudemiller N, Geurts AM, Jacob H) Am J Physiol Regul Integr Comp Physiol 2013 Mar 15;304(6):R407-14 PMID: 23364523 PMCID: PMC3602820 02/01/2013       72 Citations
  • Rab38 modulates proteinuria in model of hypertension-associated renal disease. (Rangel-Filho A, Lazar J, Moreno C, Geurts A, Jacob HJ) J Am Soc Nephrol 2013 Feb;24(2):283-92 PMID: 23291471 PMCID: PMC3559491 01/08/2013       17 Citations
  • Heterozygous knockout of transforming growth factor-β1 protects Dahl S rats against high salt-induced renal injury. (Chen CC, Geurts AM, Jacob HJ, Fan F, Roman RJ) Physiol Genomics 2013 Feb 04;45(3):110-8 PMID: 23249995 PMCID: PMC3568879 12/20/2012       8 Citations
  • Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits. (Katter K, Geurts AM, Hoffmann O, Mátés L, Landa V, Hiripi L, Moreno C, Lazar J, Bashir S, Zidek V, Popova E, Jerchow B, Becker K, Devaraj A, Walter I, Grzybowksi M, Corbett M, Filho AR, Hodges MR, Bader M, Ivics Z, Jacob HJ, Pravenec M, Bosze Z, Rülicke T, Izsvák Z) FASEB J 2013 Mar;27(3):930-41 PMID: 23195032 PMCID: PMC3574282 12/01/2012       48 Citations
  • High-throughput phenotyping of avoidance learning in mice discriminates different genotypes and identifies a novel gene. (Maroteaux G, Loos M, van der Sluis S, Koopmans B, Aarts E, van Gassen K, Geurts A, NeuroBSIK Mouse Phenomics Consortium, Largaespada DA, Spruijt BM, Stiedl O, Smit AB, Verhage M) Genes Brain Behav 2012 Oct;11(7):772-84 PMID: 22846151 PMCID: PMC3508728 08/01/2012       25 Citations
  • Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension. (Feng D, Yang C, Geurts AM, Kurth T, Liang M, Lazar J, Mattson DL, O'Connor PM, Cowley AW Jr) Cell Metab 2012 Feb 08;15(2):201-8 PMID: 22326221 PMCID: PMC3280886 02/14/2012       74 Citations
  • Efficient non-viral integration and stable gene expression in multipotent adult progenitor cells. (Wilber A, Ulloa Montoya F, Hammer L, Moriarity BS, Geurts AM, Largaespada DA, Verfaillie CM, McIvor RS, Lakshmipathy U) Stem Cells Int 2011;2011:717069 PMID: 21977042 PMCID: PMC3184415 10/07/2011    
  • The emerging role for rat models in gene discovery. (Dwinell MR, Lazar J, Geurts AM) Mamm Genome 2011 Aug;22(7-8):466-75 PMID: 21732192 PMCID: PMC3643810 07/07/2011       19 Citations
  • Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase. (Xu D, Guo H, Xu X, Lu Z, Fassett J, Hu X, Xu Y, Tang Q, Hu D, Somani A, Geurts AM, Ostertag E, Bache RJ, Weir EK, Chen Y) Hypertension 2011 Aug;58(2):303-9 PMID: 21730301 PMCID: PMC3170043 07/07/2011       34 Citations
  • Creation and characterization of a renin knockout rat. (Moreno C, Hoffman M, Stodola TJ, Didier DN, Lazar J, Geurts AM, North PE, Jacob HJ, Greene AS) Hypertension 2011 Mar;57(3):614-9 PMID: 21242461 PMCID: PMC3513323 01/19/2011       46 Citations
  • Disruption of the neuregulin 1 gene in the rat alters HPA axis activity and behavioral responses to environmental stimuli. (Taylor SB, Taylor AR, Markham JA, Geurts AM, Kanaskie BZ, Koenig JI) Physiol Behav 2011 Aug 03;104(2):205-14 PMID: 21092742 PMCID: PMC3081908 11/26/2010       25 Citations
  • Gene targeting in the rat: advances and opportunities. (Jacob HJ, Lazar J, Dwinell MR, Moreno C, Geurts AM) Trends Genet 2010 Dec;26(12):510-8 PMID: 20869786 PMCID: PMC2991520 09/28/2010       76 Citations
  • Zinc-finger nucleases: new strategies to target the rat genome. (Geurts AM, Moreno C) Clin Sci (Lond) 2010 Jul 06;119(8):303-11 PMID: 20615201 PMCID: PMC3549593 07/10/2010       27 Citations
  • Efficient mammalian germline transgenesis by cis-enhanced Sleeping Beauty transposition. (Carlson DF, Geurts AM, Garbe JR, Park CW, Rangel-Filho A, O'Grady SM, Jacob HJ, Steer CJ, Largaespada DA, Fahrenkrug SC) Transgenic Res 2011 Feb;20(1):29-45 PMID: 20352328 PMCID: PMC3516389 03/31/2010       22 Citations
  • Generation of gene-specific mutated rats using zinc-finger nucleases. (Geurts AM, Cost GJ, Rémy S, Cui X, Tesson L, Usal C, Ménoret S, Jacob HJ, Anegon I, Buelow R) Methods Mol Biol 2010;597:211-25 PMID: 20013236 12/17/2009       71 Citations
  • Knockout rats via embryo microinjection of zinc-finger nucleases. (Geurts AM, Cost GJ, Freyvert Y, Zeitler B, Miller JC, Choi VM, Jenkins SS, Wood A, Cui X, Meng X, Vincent A, Lam S, Michalkiewicz M, Schilling R, Foeckler J, Kalloway S, Weiler H, Ménoret S, Anegon I, Davis GD, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Jacob HJ, Buelow R) Science 2009 Jul 24;325(5939):433 PMID: 19628861 PMCID: PMC2831805 07/25/2009       621 Citations
  • Progress and prospects in rat genetics: a community view. (Aitman TJ, Critser JK, Cuppen E, Dominiczak A, Fernandez-Suarez XM, Flint J, Gauguier D, Geurts AM, Gould M, Harris PC, Holmdahl R, Hubner N, Izsvák Z, Jacob HJ, Kuramoto T, Kwitek AE, Marrone A, Mashimo T, Moreno C, Mullins J, Mullins L, Olsson T, Pravenec M, Riley L, Saar K, Serikawa T, Shull JD, Szpirer C, Twigger SN, Voigt B, Worley K) Nat Genet 2008 May;40(5):516-22 PMID: 18443588 04/30/2008       189 Citations
  • Predicting preferential DNA vector insertion sites: implications for functional genomics and gene therapy. (Hackett CS, Geurts AM, Hackett PB) Genome Biol 2007;8 Suppl 1:S12 PMID: 18047689 PMCID: PMC2106846 12/06/2007       48 Citations
  • Generation of rat mutants using a coat color-tagged Sleeping Beauty transposon system. (Lu B, Geurts AM, Poirier C, Petit DC, Harrison W, Overbeek PA, Bishop CE) Mamm Genome 2007 May;18(5):338-46 PMID: 17557177 06/09/2007       63 Citations
  • Efficient transgenic rat production by a lentiviral vector. (Michalkiewicz M, Michalkiewicz T, Geurts AM, Roman RJ, Slocum GR, Singer O, Weihrauch D, Greene AS, Kaldunski M, Verma IM, Jacob HJ, Cowley AW Jr) Am J Physiol Heart Circ Physiol 2007 Jul;293(1):H881-94 PMID: 17322424 02/27/2007       35 Citations
  • Harnessing a high cargo-capacity transposon for genetic applications in vertebrates. (Balciunas D, Wangensteen KJ, Wilber A, Bell J, Geurts A, Sivasubbu S, Wang X, Hackett PB, Largaespada DA, McIvor RS, Ekker SC) PLoS Genet 2006 Nov 10;2(11):e169 PMID: 17096595 PMCID: PMC1635535 11/14/2006       141 Citations
  • Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers. (Geurts AM, Collier LS, Geurts JL, Oseth LL, Bell ML, Mu D, Lucito R, Godbout SA, Green LE, Lowe SW, Hirsch BA, Leinwand LA, Largaespada DA) PLoS Genet 2006 Sep 29;2(9):e156 PMID: 17009875 PMCID: PMC1584263 10/03/2006       54 Citations
  • Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon. (Geurts AM, Wilber A, Carlson CM, Lobitz PD, Clark KJ, Hackett PB, McIvor RS, Largaespada DA) BMC Biotechnol 2006 Jun 26;6:30 PMID: 16800892 PMCID: PMC1557845 06/28/2006       34 Citations
  • Structure-based prediction of insertion-site preferences of transposons into chromosomes. (Geurts AM, Hackett CS, Bell JB, Bergemann TL, Collier LS, Carlson CM, Largaespada DA, Hackett PB) Nucleic Acids Res 2006;34(9):2803-11 PMID: 16717285 PMCID: PMC1464413 05/24/2006       55 Citations
  • Target-site preferences of Sleeping Beauty transposons. (Liu G, Geurts AM, Yae K, Srinivasan AR, Fahrenkrug SC, Largaespada DA, Takeda J, Horie K, Olson WK, Hackett PB) J Mol Biol 2005 Feb 11;346(1):161-73 PMID: 15663935 01/25/2005       106 Citations
  • Transposon vectors for gene-trap insertional mutagenesis in vertebrates. (Clark KJ, Geurts AM, Bell JB, Hackett PB) Genesis 2004 Aug;39(4):225-33 PMID: 15286994 08/03/2004       49 Citations
  • Gene transfer into genomes of human cells by the sleeping beauty transposon system. (Geurts AM, Yang Y, Clark KJ, Liu G, Cui Z, Dupuy AJ, Bell JB, Largaespada DA, Hackett PB) Mol Ther 2003 Jul;8(1):108-17 PMID: 12842434 07/05/2003       264 Citations
  • Structure-function analysis of the inverted terminal repeats of the sleeping beauty transposon. (Cui Z, Geurts AM, Liu G, Kaufman CD, Hackett PB) J Mol Biol 2002 May 17;318(5):1221-35 PMID: 12083513 06/27/2002       168 Citations
  • Last update: 11/06/2018
    jenkins-FCD Prod-296 4db9d02597e0a2e889e230f853b641c12f1c3ee3