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Aron Geurts PhD

Aron Geurts PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Physiology
Program: Genetics

Member of the Cardiovascular Center
Member of the Genomic Sciences and Precision Medicine Center (GSPMC)


I am willing to collaborate on research projects.


Research Experience

  • Animals, Genetically Modified
  • Biotechnology
  • DNA Transposable Elements
  • Genetic Engineering
  • Genetic Research
  • Organisms, Genetically Modified
  • Plasmids
  • Rats
  • Methodologies and Techniques

  • Animals, Genetically Modified
  • Biotechnology
  • Cloning, Molecular
  • Embryonic Stem Cells
  • Genetic Vectors
  • Organisms, Genetically Modified
  • Plasmids
  • Rats, Inbred BN
  • Rats, Inbred Dahl
  • Rats, Inbred Strains
  • Sequence Analysis, DNA
  • MCW Program / Core Facilities

  • Rat Transgenic Service Center
  • Publications (99)

  • Fumarase Overexpression Abolishes Hypertension Attributable to endothelial NO synthase Haploinsufficiency in Dahl Salt-Sensitive Rats. (Xue H, Geurts AM, Usa K, Wang F, Lin Y, Phillips J, Henderson L, Baker MA, Tian Z, Liang M) Hypertension 2019 Aug;74(2):313-322 PMID: 31230549 PMCID: PMC6620137 SCOPUS ID: 2-s2.0-85069627359 06/25/2019    
  • The p52 isoform of SHC1 is a key driver of breast cancer initiation. (Wright KD, Miller BS, El-Meanawy S, Tsaih SW, Banerjee A, Geurts AM, Sheinin Y, Sun Y, Kalyanaraman B, Rui H, Flister MJ, Sorokin A) Breast Cancer Res 2019 06 15;21(1):74 PMID: 31202267 PMCID: PMC6570928 SCOPUS ID: 2-s2.0-85067234098 06/17/2019    
  • Hepatic pathology and altered gene transcription in a murine model of acid ceramidase deficiency. (Yu FPS, Molino S, Sikora J, Rasmussen S, Rybova J, Tate E, Geurts AM, Turner PV, Mckillop WM, Medin JA) Lab Invest 2019 Oct;99(10):1572-1592 PMID: 31186526 SCOPUS ID: 2-s2.0-85067402206 06/13/2019    
  • Knockout of Dual-Specificity Protein Phosphatase 5 Protects Against Hypertension-Induced Renal Injury. (Zhang C, He X, Murphy SR, Zhang H, Wang S, Ge Y, Gao W, Williams JM, Geurts AM, Roman RJ, Fan F) J Pharmacol Exp Ther 2019 Aug;370(2):206-217 PMID: 31118214 PMCID: PMC6636243 SCOPUS ID: 2-s2.0-85070025580 05/24/2019    
  • Telomerase Deficiency Predisposes to Heart Failure and Ischemia-Reperfusion Injury. (Ait-Aissa K, Heisner JS, Norwood Toro LE, Bruemmer D, Doyon G, Harmann L, Geurts A, Camara AKS, Beyer AM) Front Cardiovasc Med 2019;6:31 PMID: 31001540 PMCID: PMC6454001 04/20/2019    
  • CD11c Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes. (Sandor AM, Lindsay RS, Dyjack N, Whitesell JC, Rios C, Bradley BJ, Haskins K, Serreze DV, Geurts AM, Chen YG, Seibold MA, Jacobelli J, Friedman RS) Front Immunol 2019;10:99 PMID: 30766536 PMCID: PMC6365440 SCOPUS ID: 2-s2.0-85061573541 02/16/2019       2 Citations
  • Effects of Hepatic Ischemia-Reperfusion Injuries and NRF2 on Transcriptional Activities of Bile Transporters in Rats. (Kim J, Martin A, Yee J, Fojut L, Geurts AM, Oshima K, Zimmerman MA, Hong JC) J Surg Res 2019 Mar;235:73-82 PMID: 30691853 SCOPUS ID: 2-s2.0-85055264636 01/30/2019    
  • MiR-192-5p in the Kidney Protects Against the Development of Hypertension. (Baker MA, Wang F, Liu Y, Kriegel AJ, Geurts AM, Usa K, Xue H, Wang D, Kong Y, Liang M) Hypertension 2019 Feb;73(2):399-406 PMID: 30595117 PMCID: PMC6339564 SCOPUS ID: 2-s2.0-85059796489 01/01/2019       2 Citations
  • A Screen Using iPSC-Derived Hepatocytes Reveals NAD as a Potential Treatment for mtDNA Depletion Syndrome. (Jing R, Corbett JL, Cai J, Beeson GC, Beeson CC, Chan SS, Dimmock DP, Lazcares L, Geurts AM, Lemasters JJ, Duncan SA) Cell Rep 2018 11 06;25(6):1469-1484.e5 PMID: 30404003 PMCID: PMC6289059 SCOPUS ID: 2-s2.0-85055754131 11/08/2018       2 Citations
  • A Hypermorphic Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8 T Cells in NOD Mice. (Presa M, Racine JJ, Dwyer JR, Lamont DJ, Ratiu JJ, Sarsani VK, Chen YG, Geurts A, Schmitz I, Stearns T, Allocco J, Chapman HD, Serreze DV) J Immunol 2018 10 01;201(7):1907-1917 PMID: 30127089 PMCID: PMC6143397 SCOPUS ID: 2-s2.0-85053474331 08/22/2018       2 Citations
  • Tissue-specific effects of targeted mutation of Mir29b1 in rats. (Xue H, Zhang G, Geurts AM, Usa K, Jensen DM, Liu Y, Widlansky ME, Liang M) EBioMedicine 2018 Sep;35:260-269 PMID: 30120082 PMCID: PMC6156712 SCOPUS ID: 2-s2.0-85051562841 08/19/2018    
  • MicroRNA-214-3p in the Kidney Contributes to the Development of Hypertension. (Liu Y, Usa K, Wang F, Liu P, Geurts AM, Li J, Williams AM, Regner KR, Kong Y, Liu H, Nie J, Liang M) J Am Soc Nephrol 2018 10;29(10):2518-2528 PMID: 30049682 PMCID: PMC6171279 SCOPUS ID: 2-s2.0-85053979457 07/28/2018       7 Citations
  • Protective role of Trpc6 knockout in the progression of diabetic kidney disease. (Spires D, Ilatovskaya DV, Levchenko V, North PE, Geurts AM, Palygin O, Staruschenko A) Am J Physiol Renal Physiol 2018 10 01;315(4):F1091-F1097 PMID: 29923767 PMCID: PMC6230750 SCOPUS ID: 2-s2.0-85056526794 06/21/2018       7 Citations
  • Sdha+/- Rats Display Minimal Muscle Pathology Without Significant Behavioral or Biochemical Abnormalities. (Siebers EM, Choi MJ, Tinklenberg JA, Beatka MJ, Ayres S, Meng H, Helbling DC, Takizawa A, Bennett B, Garces AM, Dias Duarte Machado LG, Dimmock D, Dwinell MR, Geurts AM, Lawlor MW) J Neuropathol Exp Neurol 2018 08 01;77(8):665-672 PMID: 29850869 PMCID: PMC6044411 SCOPUS ID: 2-s2.0-85054028838 06/01/2018       1 Citation
  • A NOX4/TRPC6 Pathway in Podocyte Calcium Regulation and Renal Damage in Diabetic Kidney Disease. (Ilatovskaya DV, Blass G, Palygin O, Levchenko V, Pavlov TS, Grzybowski MN, Winsor K, Shuyskiy LS, Geurts AM, Cowley AW Jr, Birnbaumer L, Staruschenko A) J Am Soc Nephrol 2018 07;29(7):1917-1927 PMID: 29793963 PMCID: PMC6050934 SCOPUS ID: 2-s2.0-85049383067 05/26/2018       10 Citations
  • Genome-wide map of proximity linkage to renin proximal promoter in rat. (Stodola TJ, Liu P, Liu Y, Vallejos AK, Geurts AM, Greene AS, Liang M) Physiol Genomics 2018 05 01;50(5):323-331 PMID: 29521603 PMCID: PMC6008118 SCOPUS ID: 2-s2.0-85061579448 03/10/2018       2 Citations
  • Characterization of Coding/Noncoding Variants for in Patients with CKD. (Prokop JW, Yeo NC, Ottmann C, Chhetri SB, Florus KL, Ross EJ, Sosonkina N, Link BA, Freedman BI, Coppola CJ, McDermott-Roe C, Leysen S, Milroy LG, Meijer FA, Geurts AM, Rauscher FJ 3rd, Ramaker R, Flister MJ, Jacob HJ, Mendenhall EM, Lazar J) J Am Soc Nephrol 2018 05;29(5):1525-1535 PMID: 29476007 PMCID: PMC5967772 SCOPUS ID: 2-s2.0-85046380339 02/25/2018       4 Citations
  • miR-29 contributes to normal endothelial function and can restore it in cardiometabolic disorders. (Widlansky ME, Jensen DM, Wang J, Liu Y, Geurts AM, Kriegel AJ, Liu P, Ying R, Zhang G, Casati M, Chu C, Malik M, Branum A, Tanner MJ, Tyagi S, Usa K, Liang M) EMBO Mol Med 2018 03;10(3) PMID: 29374012 PMCID: PMC5840545 SCOPUS ID: 2-s2.0-85041063208 01/28/2018       15 Citations
  • Keratinocytes mediate innocuous and noxious touch via ATP-P2X4 signaling. (Moehring F, Cowie AM, Menzel AD, Weyer AD, Grzybowski M, Arzua T, Geurts AM, Palygin O, Stucky CL) Elife 2018 01 16;7 PMID: 29336303 PMCID: PMC5777822 SCOPUS ID: 2-s2.0-85042135972 01/18/2018       19 Citations
  • Determination of total plasma oxysterols by enzymatic hydrolysis, solid phase extraction and liquid chromatography coupled to mass-spectrometry. (Mendiara I, Domeño C, Nerín C, Geurts AM, Osada J, Martínez-Beamonte R) J Pharm Biomed Anal 2018 Feb 20;150:396-405 PMID: 29288965 SCOPUS ID: 2-s2.0-85039461303 12/31/2017       1 Citation
  • Evaluation of Vascular Control Mechanisms Utilizing Video Microscopy of Isolated Resistance Arteries of Rats. (Lukaszewicz KM, Durand MJ, Priestley JRC, Schmidt JR, Allen LA, Geurts AM, Lombard JH) J Vis Exp 2017 12 05(130) PMID: 29286398 PMCID: PMC5755532 SCOPUS ID: 2-s2.0-85037691517 12/30/2017    
  • Nitric oxide production by glomerular podocytes. (Palygin O, Ilatovskaya DV, Levchenko V, Endres BT, Geurts AM, Staruschenko A) Nitric Oxide 2018 01 30;72:24-31 PMID: 29128399 PMCID: PMC5776695 SCOPUS ID: 2-s2.0-85034073816 11/13/2017    
  • In vitro characterization of mitochondrial function and structure in rat and human cells with a deficiency of the NADH: ubiquinone oxidoreductase Ndufc2 subunit. (Raffa S, Scrofani C, Valente S, Micaloni A, Forte M, Bianchi F, Coluccia R, Geurts AM, Sciarretta S, Volpe M, Torrisi MR, Rubattu S) Hum Mol Genet 2017 12 01;26(23):4541-4555 PMID: 28973657 PMCID: PMC5886163 SCOPUS ID: 2-s2.0-85042218912 10/04/2017       5 Citations
  • Essential role of Kir5.1 channels in renal salt handling and blood pressure control. (Palygin O, Levchenko V, Ilatovskaya DV, Pavlov TS, Pochynyuk OM, Jacob HJ, Geurts AM, Hodges MR, Staruschenko A) JCI Insight 2017 09 21;2(18) PMID: 28931751 PMCID: PMC5621918 SCOPUS ID: 2-s2.0-85049388582 09/22/2017       7 Citations
  • Active sleep unmasks apnea and delayed arousal in infant rat pups lacking central serotonin. (Young JO, Geurts A, Hodges MR, Cummings KJ) J Appl Physiol (1985) 2017 Oct 01;123(4):825-834 PMID: 28775068 PMCID: PMC5668447 SCOPUS ID: 2-s2.0-85032432081 08/05/2017       8 Citations
  • Elevation of fumarase attenuates hypertension and can result from a nonsynonymous sequence variation or increased expression depending on rat strain. (Usa K, Liu Y, Geurts AM, Cheng Y, Lazar J, Baker MA, Grzybowski M, He Y, Tian Z, Liang M) Physiol Genomics 2017 Sep 01;49(9):496-504 PMID: 28754823 PMCID: PMC5625267 SCOPUS ID: 2-s2.0-85029592375 07/30/2017       6 Citations
  • Host genetic modifiers of nonproductive angiogenesis inhibit breast cancer. (Flister MJ, Tsaih SW, Stoddard A, Plasterer C, Jagtap J, Parchur AK, Sharma G, Prisco AR, Lemke A, Murphy D, Al-Gizawiy M, Straza M, Ran S, Geurts AM, Dwinell MR, Greene AS, Bergom C, LaViolette PS, Joshi A) Breast Cancer Res Treat 2017 Aug;165(1):53-64 PMID: 28567545 PMCID: PMC6404538 SCOPUS ID: 2-s2.0-85020059895 06/02/2017       7 Citations
  • Intravital imaging of the kidney in a rat model of salt-sensitive hypertension. (Endres BT, Sandoval RM, Rhodes GJ, Campos-Bilderback SB, Kamocka MM, McDermott-Roe C, Staruschenko A, Molitoris BA, Geurts AM, Palygin O) Am J Physiol Renal Physiol 2017 Aug 01;313(2):F163-F173 PMID: 28404591 PMCID: PMC5582897 SCOPUS ID: 2-s2.0-85026777997 04/14/2017       5 Citations
  • Lung injury pathways: Adenosine receptor 2B signaling limits development of ischemic bronchiolitis obliterans organizing pneumonia. (Densmore JC, Schaid TR, Jeziorczak PM, Medhora M, Audi S, Nayak S, Auchampach J, Dwinell MR, Geurts AM, Jacobs ER) Exp Lung Res 2017 02;43(1):38-48 PMID: 28266889 PMCID: PMC5831175 SCOPUS ID: 2-s2.0-85014510215 03/08/2017       3 Citations
  • Efficient Precision Genome Editing in iPSCs via Genetic Co-targeting with Selection. (Mitzelfelt KA, McDermott-Roe C, Grzybowski MN, Marquez M, Kuo CT, Riedel M, Lai S, Choi MJ, Kolander KD, Helbling D, Dimmock DP, Battle MA, Jou CJ, Tristani-Firouzi M, Verbsky JW, Benjamin IJ, Geurts AM) Stem Cell Reports 2017 03 14;8(3):491-499 PMID: 28238794 PMCID: PMC5355643 SCOPUS ID: 2-s2.0-85013648619 02/28/2017       9 Citations
  • Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function. (McDermott-Roe C, Leleu M, Rowe GC, Palygin O, Bukowy JD, Kuo J, Rech M, Hermans-Beijnsberger S, Schaefer S, Adami E, Creemers EE, Heinig M, Schroen B, Arany Z, Petretto E, Geurts AM) PLoS One 2017;12(2):e0170458 PMID: 28158196 PMCID: PMC5291451 SCOPUS ID: 2-s2.0-85011660702 02/06/2017       2 Citations
  • ISH ADA-01 Critical role of telomerase in regulating cerebral vascular function and redox environment. (Ait-Aissa K, Hockenberry J, Gutterman D, Geurts A, Beyer A) J Hypertens 2016 Sep;34 Suppl 1 - ISH 2016 Abstract Book:e39 PMID: 27753880 10/19/2016    
  • A RATional choice for translational research? (Aitman T, Dhillon P, Geurts AM) Dis Model Mech 2016 10 01;9(10):1069-1072 PMID: 27736742 PMCID: PMC5087836 SCOPUS ID: 2-s2.0-84993949166 10/14/2016       17 Citations
  • ISH ADA-01 Critical role of telomerase in regulating cerebral vascular function and redox environment. (Ait-Aissa K, Hockenberry J, Gutterman D, Geurts A, Beyer A) J Hypertens 2016 Sep;34 Suppl 1:e39 PMID: 27643173 09/20/2016    
  • Early development of podocyte injury independently of hyperglycemia and elevations in arterial pressure in nondiabetic obese Dahl SS leptin receptor mutant rats. (McPherson KC, Taylor L, Johnson AC, Didion SP, Geurts AM, Garrett MR, Williams JM) Am J Physiol Renal Physiol 2016 10 01;311(4):F793-F804 PMID: 27465994 PMCID: PMC5142236 SCOPUS ID: 2-s2.0-84989932218 07/29/2016       1 Citation
  • Gene Editing: Practical Application in the Lab. (Geurts AM, Ekker SC) Hum Gene Ther 2016 06;27(6):417-8 PMID: 27322167 PMCID: PMC5583549 SCOPUS ID: 2-s2.0-84975523278 06/21/2016       1 Citation
  • p66Shc regulates renal vascular tone in hypertension-induced nephropathy. (Miller B, Palygin O, Rufanova VA, Chong A, Lazar J, Jacob HJ, Mattson D, Roman RJ, Williams JM, Cowley AW Jr, Geurts AM, Staruschenko A, Imig JD, Sorokin A) J Clin Invest 2016 07 01;126(7):2533-46 PMID: 27270176 PMCID: PMC4922697 SCOPUS ID: 2-s2.0-84978419542 06/09/2016       9 Citations
  • The Human 343delT HSPB5 Chaperone Associated with Early-onset Skeletal Myopathy Causes Defects in Protein Solubility. (Mitzelfelt KA, Limphong P, Choi MJ, Kondrat FD, Lai S, Kolander KD, Kwok WM, Dai Q, Grzybowski MN, Zhang H, Taylor GM, Lui Q, Thao MT, Hudson JA, Barresi R, Bushby K, Jungbluth H, Wraige E, Geurts AM, Benesch JL, Riedel M, Christians ES, Minella AC, Benjamin IJ) J Biol Chem 2016 07 15;291(29):14939-53 PMID: 27226619 PMCID: PMC4946913 SCOPUS ID: 2-s2.0-84978431927 05/27/2016       4 Citations
  • Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure. (Kuijk EW, Rasmussen S, Blokzijl F, Huch M, Gehart H, Toonen P, Begthel H, Clevers H, Geurts AM, Cuppen E) Sci Rep 2016 Feb 26;6:22154 PMID: 26915950 PMCID: PMC4768167 SCOPUS ID: 2-s2.0-84959258808 02/27/2016       20 Citations
  • Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease. (Rubattu S, Di Castro S, Schulz H, Geurts AM, Cotugno M, Bianchi F, Maatz H, Hummel O, Falak S, Stanzione R, Marchitti S, Scarpino S, Giusti B, Kura A, Gensini GF, Peyvandi F, Mannucci PM, Rasura M, Sciarretta S, Dwinell MR, Hubner N, Volpe M) J Am Heart Assoc 2016 Feb 17;5(2) PMID: 26888427 PMCID: PMC4802485 SCOPUS ID: 2-s2.0-84995488392 02/19/2016    
  • Chronic central serotonin depletion attenuates ventilation and body temperature in young but not adult Tph2 knockout rats. (Kaplan K, Echert AE, Massat B, Puissant MM, Palygin O, Geurts AM, Hodges MR) J Appl Physiol (1985) 2016 05 01;120(9):1070-81 PMID: 26869713 PMCID: PMC4855209 SCOPUS ID: 2-s2.0-84984672514 02/13/2016       10 Citations
  • Potentially diagnostic electron paramagnetic resonance spectra elucidate the underlying mechanism of mitochondrial dysfunction in the deoxyguanosine kinase deficient rat model of a genetic mitochondrial DNA depletion syndrome. (Bennett B, Helbling D, Meng H, Jarzembowski J, Geurts AM, Friederich MW, Van Hove JLK, Lawlor MW, Dimmock DP) Free Radic Biol Med 2016 Mar;92:141-151 PMID: 26773591 PMCID: PMC5047058 SCOPUS ID: 2-s2.0-84957568061 01/17/2016       7 Citations
  • Evidence of the Importance of Nox4 in Production of Hypertension in Dahl Salt-Sensitive Rats. (Cowley AW Jr, Yang C, Zheleznova NN, Staruschenko A, Kurth T, Rein L, Kumar V, Sadovnikov K, Dayton A, Hoffman M, Ryan RP, Skelton MM, Salehpour F, Ranji M, Geurts A) Hypertension 2016 Feb;67(2):440-50 PMID: 26644237 PMCID: PMC4713301 SCOPUS ID: 2-s2.0-84954403695 12/09/2015       35 Citations
  • The NRF2 knockout rat: a new animal model to study endothelial dysfunction, oxidant stress, and microvascular rarefaction. (Priestley JR, Kautenburg KE, Casati MC, Endres BT, Geurts AM, Lombard JH) Am J Physiol Heart Circ Physiol 2016 Feb 15;310(4):H478-87 PMID: 26637559 PMCID: PMC4796617 SCOPUS ID: 2-s2.0-84958559081 12/08/2015       20 Citations
  • Pappa2 is linked to salt-sensitive hypertension in Dahl S rats. (Cowley AW Jr, Yang C, Kumar V, Lazar J, Jacob H, Geurts AM, Liu P, Dayton A, Kurth T, Liang M) Physiol Genomics 2016 Jan;48(1):62-72 PMID: 26534937 PMCID: PMC4757026 SCOPUS ID: 2-s2.0-84953280775 11/05/2015       11 Citations
  • Expression and function of the Scn5a-encoded voltage-gated sodium channel NaV 1.5 in the rat jejunum. (Beyder A, Gibbons SJ, Mazzone A, Strege PR, Saravanaperumal SA, Sha L, Higgins S, Eisenman ST, Bernard CE, Geurts A, Kline CF, Mohler PJ, Farrugia G) Neurogastroenterol Motil 2016 Jan;28(1):64-73 PMID: 26459913 PMCID: PMC4688076 SCOPUS ID: 2-s2.0-84952637081 10/16/2015       4 Citations
  • Myosin Id is required for planar cell polarity in ciliated tracheal and ependymal epithelial cells. (Hegan PS, Ostertag E, Geurts AM, Mooseker MS) Cytoskeleton (Hoboken) 2015 Oct;72(10):503-16 PMID: 26446290 PMCID: PMC4715625 SCOPUS ID: 2-s2.0-84954392734 10/09/2015       13 Citations
  • Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension. (Nayak S, Khan MA, Wan TC, Pei H, Linden J, Dwinell MR, Geurts AM, Imig JD, Auchampach JA) Purinergic Signal 2015 Dec;11(4):519-31 PMID: 26385692 PMCID: PMC4648794 SCOPUS ID: 2-s2.0-84947616348 09/20/2015       5 Citations
  • Two-photon Imaging of Intracellular Ca2+ Handling and Nitric Oxide Production in Endothelial and Smooth Muscle Cells of an Isolated Rat Aorta. (Endres BT, Staruschenko A, Schulte M, Geurts AM, Palygin O) J Vis Exp 2015 Jun 10(100):e52734 PMID: 26132549 PMCID: PMC4545029 SCOPUS ID: 2-s2.0-84941241987 07/02/2015       2 Citations
  • Antithrombin III/SerpinC1 insufficiency exacerbates renal ischemia/reperfusion injury. (Wang F, Zhang G, Lu Z, Geurts AM, Usa K, Jacob HJ, Cowley AW, Wang N, Liang M) Kidney Int 2015 Oct;88(4):796-803 PMID: 26108065 PMCID: PMC4589441 SCOPUS ID: 2-s2.0-84942983545 06/25/2015       36 Citations
  • B-Type Natriuretic Peptide Deletion Leads to Progressive Hypertension, Associated Organ Damage, and Reduced Survival: Novel Model for Human Hypertension. (Holditch SJ, Schreiber CA, Nini R, Tonne JM, Peng KW, Geurts A, Jacob HJ, Burnett JC, Cataliotti A, Ikeda Y) Hypertension 2015 Jul;66(1):199-210 PMID: 26063669 PMCID: PMC4467451 SCOPUS ID: 2-s2.0-84941598794 06/13/2015       25 Citations
  • 2015 Guidelines for Establishing Genetically Modified Rat Models for Cardiovascular Research. (Flister MJ, Prokop JW, Lazar J, Shimoyama M, Dwinell M, Geurts A, International Committee on Standardized Genetic Nomenclature for Mice, Rat Genome and Nomenclature Committee) J Cardiovasc Transl Res 2015 Jun;8(4):269-77 PMID: 25920443 PMCID: PMC4475456 SCOPUS ID: 2-s2.0-84931568348 04/30/2015       13 Citations
  • Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease. (Qin W, Dion SL, Kutny PM, Zhang Y, Cheng AW, Jillette NL, Malhotra A, Geurts AM, Chen YG, Wang H) Genetics 2015 Jun;200(2):423-30 PMID: 25819794 PMCID: PMC4492369 SCOPUS ID: 2-s2.0-84931385060 03/31/2015       88 Citations
  • Mutation of SH2B3 (LNK), a genome-wide association study candidate for hypertension, attenuates Dahl salt-sensitive hypertension via inflammatory modulation. (Rudemiller NP, Lund H, Priestley JR, Endres BT, Prokop JW, Jacob HJ, Geurts AM, Cohen EP, Mattson DL) Hypertension 2015 May;65(5):1111-7 PMID: 25776069 PMCID: PMC4412596 SCOPUS ID: 2-s2.0-84937509309 03/18/2015       29 Citations
  • SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis. (Flister MJ, Hoffman MJ, Lemke A, Prisco SZ, Rudemiller N, O'Meara CC, Tsaih SW, Moreno C, Geurts AM, Lazar J, Adhikari N, Hall JL, Jacob HJ) Circ Cardiovasc Genet 2015 Apr;8(2):294-304 PMID: 25628389 SCOPUS ID: 2-s2.0-84942919523 01/30/2015       6 Citations
  • Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat. (Fan F, Geurts AM, Murphy SR, Pabbidi MR, Jacob HJ, Roman RJ) Am J Physiol Regul Integr Comp Physiol 2015 Mar 01;308(5):R379-90 PMID: 25540098 PMCID: PMC4346760 SCOPUS ID: 2-s2.0-84923860726 12/30/2014       15 Citations
  • Targeted disruption of Tbc1d20 with zinc-finger nucleases causes cataracts and testicular abnormalities in mice. (Park AK, Liegel RP, Ronchetti A, Ebert AD, Geurts A, Sidjanin DJ) BMC Genet 2014 Dec 05;15:135 PMID: 25476608 PMCID: PMC4266191 SCOPUS ID: 2-s2.0-84964313193 12/06/2014       9 Citations
  • Maternal diet during gestation and lactation modifies the severity of salt-induced hypertension and renal injury in Dahl salt-sensitive rats. (Geurts AM, Mattson DL, Liu P, Cabacungan E, Skelton MM, Kurth TM, Yang C, Endres BT, Klotz J, Liang M, Cowley AW Jr) Hypertension 2015 Feb;65(2):447-55 PMID: 25452472 PMCID: PMC4289102 SCOPUS ID: 2-s2.0-84921562280 12/03/2014       30 Citations
  • Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats. (Fan F, Geurts AM, Pabbidi MR, Smith SV, Harder DR, Jacob H, Roman RJ) PLoS One 2014;9(11):e112878 PMID: 25397684 PMCID: PMC4232417 SCOPUS ID: 2-s2.0-84911866190 11/15/2014       13 Citations
  • CXM: a new tool for mapping breast cancer risk in the tumor microenvironment. (Flister MJ, Endres BT, Rudemiller N, Sarkis AB, Santarriaga S, Roy I, Lemke A, Geurts AM, Moreno C, Ran S, Tsaih SW, De Pons J, Carlson DF, Tan W, Fahrenkrug SC, Lazarova Z, Lazar J, North PE, LaViolette PS, Dwinell MB, Shull JD, Jacob HJ) Cancer Res 2014 Nov 15;74(22):6419-29 PMID: 25172839 PMCID: PMC4247541 SCOPUS ID: 2-s2.0-84918497707 08/31/2014       13 Citations
  • Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat. (Endres BT, Priestley JR, Palygin O, Flister MJ, Hoffman MJ, Weinberg BD, Grzybowski M, Lombard JH, Staruschenko A, Moreno C, Jacob HJ, Geurts AM) Proc Natl Acad Sci U S A 2014 Sep 02;111(35):12817-22 PMID: 25136115 PMCID: PMC4156702 SCOPUS ID: 2-s2.0-84907228029 08/20/2014       26 Citations
  • HV1 acts as a sodium sensor and promotes superoxide production in medullary thick ascending limb of Dahl salt-sensitive rats. (Jin C, Sun J, Stilphen CA, Smith SM, Ocasio H, Bermingham B, Darji S, Guha A, Patel R, Geurts AM, Jacob HJ, Lambert NA, O'Connor PM) Hypertension 2014 Sep;64(3):541-50 PMID: 24935944 PMCID: PMC4324599 SCOPUS ID: 2-s2.0-84907598794 06/18/2014       13 Citations
  • Germline transgenesis in rabbits by pronuclear microinjection of Sleeping Beauty transposons. (Ivics Z, Hiripi L, Hoffmann OI, Mátés L, Yau TY, Bashir S, Zidek V, Landa V, Geurts A, Pravenec M, Rülicke T, Bösze Z, Izsvák Z) Nat Protoc 2014 Apr;9(4):794-809 PMID: 24625779 SCOPUS ID: 2-s2.0-84897143633 03/15/2014       27 Citations
  • Germline transgenesis in pigs by cytoplasmic microinjection of Sleeping Beauty transposons. (Ivics Z, Garrels W, Mátés L, Yau TY, Bashir S, Zidek V, Landa V, Geurts A, Pravenec M, Rülicke T, Kues WA, Izsvák Z) Nat Protoc 2014 Apr;9(4):810-27 PMID: 24625780 SCOPUS ID: 2-s2.0-84897143787 03/15/2014       45 Citations
  • Germline transgenesis in rodents by pronuclear microinjection of Sleeping Beauty transposons. (Ivics Z, Mátés L, Yau TY, Landa V, Zidek V, Bashir S, Hoffmann OI, Hiripi L, Garrels W, Kues WA, Bösze Z, Geurts A, Pravenec M, Rülicke T, Izsvák Z) Nat Protoc 2014 Apr;9(4):773-93 PMID: 24625778 SCOPUS ID: 2-s2.0-84897127002 03/15/2014       35 Citations
  • CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney. (Rudemiller N, Lund H, Jacob HJ, Geurts AM, Mattson DL, PhysGen Knockout Program) Hypertension 2014 Mar;63(3):559-64 PMID: 24343121 PMCID: PMC3945169 SCOPUS ID: 2-s2.0-84894492650 12/18/2013       57 Citations
  • Amelioration of salt-induced vascular dysfunction in mesenteric arteries of Dahl salt-sensitive rats by missense mutation of extracellular superoxide dismutase. (Beyer AM, Raffai G, Weinberg BD, Fredrich K, Rodgers MS, Geurts AM, Jacob HJ, Dwinell MR, Lombard JH) Am J Physiol Heart Circ Physiol 2014 Feb;306(3):H339-47 PMID: 24322611 PMCID: PMC3920146 SCOPUS ID: 2-s2.0-84893409421 12/11/2013       6 Citations
  • Retraction of "Derivation and genetic modification of embryonic stem cells from disease-model inbred rat strains". Stem Cells Dev 2013 Oct 15;22(20):2813 PMID: 24083560 SCOPUS ID: 2-s2.0-84885161462 10/03/2013    
  • Identifying multiple causative genes at a single GWAS locus. (Flister MJ, Tsaih SW, O'Meara CC, Endres B, Hoffman MJ, Geurts AM, Dwinell MR, Lazar J, Jacob HJ, Moreno C) Genome Res 2013 Dec;23(12):1996-2002 PMID: 24006081 PMCID: PMC3847770 SCOPUS ID: 2-s2.0-84888132259 09/06/2013       52 Citations
  • Gene targeting in NOD mouse embryos using zinc-finger nucleases. (Chen YG, Forsberg MH, Khaja S, Ciecko AE, Hessner MJ, Geurts AM) Diabetes 2014 Jan;63(1):68-74 PMID: 23974926 PMCID: PMC3868049 08/27/2013    
  • Rats are the smart choice: Rationale for a renewed focus on rats in behavioral genetics. (Parker CC, Chen H, Flagel SB, Geurts AM, Richards JB, Robinson TE, Solberg Woods LC, Palmer AA) Neuropharmacology 2014 Jan;76 Pt B:250-8 PMID: 23791960 PMCID: PMC3823679 SCOPUS ID: 2-s2.0-84887068500 06/25/2013       34 Citations
  • Genetic mutation of recombination activating gene 1 in Dahl salt-sensitive rats attenuates hypertension and renal damage. (Mattson DL, Lund H, Guo C, Rudemiller N, Geurts AM, Jacob H) Am J Physiol Regul Integr Comp Physiol 2013 Mar 15;304(6):R407-14 PMID: 23364523 PMCID: PMC3602820 SCOPUS ID: 2-s2.0-84877109327 02/01/2013       87 Citations
  • Rab38 modulates proteinuria in model of hypertension-associated renal disease. (Rangel-Filho A, Lazar J, Moreno C, Geurts A, Jacob HJ) J Am Soc Nephrol 2013 Feb;24(2):283-92 PMID: 23291471 PMCID: PMC3559491 SCOPUS ID: 2-s2.0-84873357210 01/08/2013       21 Citations
  • Heterozygous knockout of transforming growth factor-β1 protects Dahl S rats against high salt-induced renal injury. (Chen CC, Geurts AM, Jacob HJ, Fan F, Roman RJ) Physiol Genomics 2013 Feb 04;45(3):110-8 PMID: 23249995 PMCID: PMC3568879 SCOPUS ID: 2-s2.0-84873418766 12/20/2012       8 Citations
  • Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits. (Katter K, Geurts AM, Hoffmann O, Mátés L, Landa V, Hiripi L, Moreno C, Lazar J, Bashir S, Zidek V, Popova E, Jerchow B, Becker K, Devaraj A, Walter I, Grzybowksi M, Corbett M, Filho AR, Hodges MR, Bader M, Ivics Z, Jacob HJ, Pravenec M, Bosze Z, Rülicke T, Izsvák Z) FASEB J 2013 Mar;27(3):930-41 PMID: 23195032 PMCID: PMC3574282 SCOPUS ID: 2-s2.0-84874610564 12/01/2012       50 Citations
  • High-throughput phenotyping of avoidance learning in mice discriminates different genotypes and identifies a novel gene. (Maroteaux G, Loos M, van der Sluis S, Koopmans B, Aarts E, van Gassen K, Geurts A, NeuroBSIK Mouse Phenomics Consortium, Largaespada DA, Spruijt BM, Stiedl O, Smit AB, Verhage M) Genes Brain Behav 2012 Oct;11(7):772-84 PMID: 22846151 PMCID: PMC3508728 SCOPUS ID: 2-s2.0-84867336581 08/01/2012       26 Citations
  • Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension. (Feng D, Yang C, Geurts AM, Kurth T, Liang M, Lazar J, Mattson DL, O'Connor PM, Cowley AW Jr) Cell Metab 2012 Feb 08;15(2):201-8 PMID: 22326221 PMCID: PMC3280886 SCOPUS ID: 2-s2.0-84863012892 02/14/2012       80 Citations
  • Efficient non-viral integration and stable gene expression in multipotent adult progenitor cells. (Wilber A, Ulloa Montoya F, Hammer L, Moriarity BS, Geurts AM, Largaespada DA, Verfaillie CM, McIvor RS, Lakshmipathy U) Stem Cells Int 2011;2011:717069 PMID: 21977042 PMCID: PMC3184415 10/07/2011    
  • Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase. (Xu D, Guo H, Xu X, Lu Z, Fassett J, Hu X, Xu Y, Tang Q, Hu D, Somani A, Geurts AM, Ostertag E, Bache RJ, Weir EK, Chen Y) Hypertension 2011 Aug;58(2):303-9 PMID: 21730301 PMCID: PMC3170043 SCOPUS ID: 2-s2.0-80051473132 07/07/2011       40 Citations
  • The emerging role for rat models in gene discovery. (Dwinell MR, Lazar J, Geurts AM) Mamm Genome 2011 Aug;22(7-8):466-75 PMID: 21732192 PMCID: PMC3643810 SCOPUS ID: 2-s2.0-80051552900 07/07/2011       21 Citations
  • Creation and characterization of a renin knockout rat. (Moreno C, Hoffman M, Stodola TJ, Didier DN, Lazar J, Geurts AM, North PE, Jacob HJ, Greene AS) Hypertension 2011 Mar;57(3):614-9 PMID: 21242461 PMCID: PMC3513323 SCOPUS ID: 2-s2.0-79953224403 01/19/2011       47 Citations
  • Disruption of the neuregulin 1 gene in the rat alters HPA axis activity and behavioral responses to environmental stimuli. (Taylor SB, Taylor AR, Markham JA, Geurts AM, Kanaskie BZ, Koenig JI) Physiol Behav 2011 Aug 03;104(2):205-14 PMID: 21092742 PMCID: PMC3081908 SCOPUS ID: 2-s2.0-79958799340 11/26/2010       27 Citations
  • Gene targeting in the rat: advances and opportunities. (Jacob HJ, Lazar J, Dwinell MR, Moreno C, Geurts AM) Trends Genet 2010 Dec;26(12):510-8 PMID: 20869786 PMCID: PMC2991520 SCOPUS ID: 2-s2.0-78549295495 09/28/2010       77 Citations
  • Zinc-finger nucleases: new strategies to target the rat genome. (Geurts AM, Moreno C) Clin Sci (Lond) 2010 Jul 06;119(8):303-11 PMID: 20615201 PMCID: PMC3549593 SCOPUS ID: 2-s2.0-77956367668 07/10/2010       29 Citations
  • Efficient mammalian germline transgenesis by cis-enhanced Sleeping Beauty transposition. (Carlson DF, Geurts AM, Garbe JR, Park CW, Rangel-Filho A, O'Grady SM, Jacob HJ, Steer CJ, Largaespada DA, Fahrenkrug SC) Transgenic Res 2011 Feb;20(1):29-45 PMID: 20352328 PMCID: PMC3516389 SCOPUS ID: 2-s2.0-78651398529 03/31/2010       23 Citations
  • Generation of gene-specific mutated rats using zinc-finger nucleases. (Geurts AM, Cost GJ, Rémy S, Cui X, Tesson L, Usal C, Ménoret S, Jacob HJ, Anegon I, Buelow R) Methods Mol Biol 2010;597:211-25 PMID: 20013236 SCOPUS ID: 2-s2.0-77449157725 12/17/2009       75 Citations
  • Knockout rats via embryo microinjection of zinc-finger nucleases. (Geurts AM, Cost GJ, Freyvert Y, Zeitler B, Miller JC, Choi VM, Jenkins SS, Wood A, Cui X, Meng X, Vincent A, Lam S, Michalkiewicz M, Schilling R, Foeckler J, Kalloway S, Weiler H, Ménoret S, Anegon I, Davis GD, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Jacob HJ, Buelow R) Science 2009 Jul 24;325(5939):433 PMID: 19628861 PMCID: PMC2831805 SCOPUS ID: 2-s2.0-67749106611 07/25/2009       646 Citations
  • Progress and prospects in rat genetics: a community view. (Aitman TJ, Critser JK, Cuppen E, Dominiczak A, Fernandez-Suarez XM, Flint J, Gauguier D, Geurts AM, Gould M, Harris PC, Holmdahl R, Hubner N, Izsvák Z, Jacob HJ, Kuramoto T, Kwitek AE, Marrone A, Mashimo T, Moreno C, Mullins J, Mullins L, Olsson T, Pravenec M, Riley L, Saar K, Serikawa T, Shull JD, Szpirer C, Twigger SN, Voigt B, Worley K) Nat Genet 2008 May;40(5):516-22 PMID: 18443588 SCOPUS ID: 2-s2.0-42649111665 04/30/2008       195 Citations
  • Predicting preferential DNA vector insertion sites: implications for functional genomics and gene therapy. (Hackett CS, Geurts AM, Hackett PB) Genome Biol 2007;8 Suppl 1:S12 PMID: 18047689 PMCID: PMC2106846 SCOPUS ID: 2-s2.0-38449089316 12/06/2007       49 Citations
  • Generation of rat mutants using a coat color-tagged Sleeping Beauty transposon system. (Lu B, Geurts AM, Poirier C, Petit DC, Harrison W, Overbeek PA, Bishop CE) Mamm Genome 2007 May;18(5):338-46 PMID: 17557177 SCOPUS ID: 2-s2.0-34547102476 06/09/2007       64 Citations
  • Efficient transgenic rat production by a lentiviral vector. (Michalkiewicz M, Michalkiewicz T, Geurts AM, Roman RJ, Slocum GR, Singer O, Weihrauch D, Greene AS, Kaldunski M, Verma IM, Jacob HJ, Cowley AW Jr) Am J Physiol Heart Circ Physiol 2007 Jul;293(1):H881-94 PMID: 17322424 SCOPUS ID: 2-s2.0-34547112080 02/27/2007       35 Citations
  • Harnessing a high cargo-capacity transposon for genetic applications in vertebrates. (Balciunas D, Wangensteen KJ, Wilber A, Bell J, Geurts A, Sivasubbu S, Wang X, Hackett PB, Largaespada DA, McIvor RS, Ekker SC) PLoS Genet 2006 Nov 10;2(11):e169 PMID: 17096595 PMCID: PMC1635535 SCOPUS ID: 2-s2.0-33751352744 11/14/2006       165 Citations
  • Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers. (Geurts AM, Collier LS, Geurts JL, Oseth LL, Bell ML, Mu D, Lucito R, Godbout SA, Green LE, Lowe SW, Hirsch BA, Leinwand LA, Largaespada DA) PLoS Genet 2006 Sep 29;2(9):e156 PMID: 17009875 PMCID: PMC1584263 SCOPUS ID: 2-s2.0-33749416026 10/03/2006       57 Citations
  • Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon. (Geurts AM, Wilber A, Carlson CM, Lobitz PD, Clark KJ, Hackett PB, McIvor RS, Largaespada DA) BMC Biotechnol 2006 Jun 26;6:30 PMID: 16800892 PMCID: PMC1557845 SCOPUS ID: 2-s2.0-33748186110 06/28/2006       34 Citations
  • Structure-based prediction of insertion-site preferences of transposons into chromosomes. (Geurts AM, Hackett CS, Bell JB, Bergemann TL, Collier LS, Carlson CM, Largaespada DA, Hackett PB) Nucleic Acids Res 2006;34(9):2803-11 PMID: 16717285 PMCID: PMC1464413 SCOPUS ID: 2-s2.0-33744827138 05/24/2006       55 Citations
  • Target-site preferences of Sleeping Beauty transposons. (Liu G, Geurts AM, Yae K, Srinivasan AR, Fahrenkrug SC, Largaespada DA, Takeda J, Horie K, Olson WK, Hackett PB) J Mol Biol 2005 Feb 11;346(1):161-73 PMID: 15663935 SCOPUS ID: 2-s2.0-19944431736 01/25/2005       107 Citations
  • Transposon vectors for gene-trap insertional mutagenesis in vertebrates. (Clark KJ, Geurts AM, Bell JB, Hackett PB) Genesis 2004 Aug;39(4):225-33 PMID: 15286994 SCOPUS ID: 2-s2.0-4444339395 08/03/2004       50 Citations
  • Gene transfer into genomes of human cells by the sleeping beauty transposon system. (Geurts AM, Yang Y, Clark KJ, Liu G, Cui Z, Dupuy AJ, Bell JB, Largaespada DA, Hackett PB) Mol Ther 2003 Jul;8(1):108-17 PMID: 12842434 SCOPUS ID: 2-s2.0-0042700227 07/05/2003       267 Citations
  • Structure-function analysis of the inverted terminal repeats of the sleeping beauty transposon. (Cui Z, Geurts AM, Liu G, Kaufman CD, Hackett PB) J Mol Biol 2002 May 17;318(5):1221-35 PMID: 12083513 SCOPUS ID: 2-s2.0-0036317929 06/27/2002       171 Citations
  • Last update: 08/22/2019
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