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Medical College of Wisconsin

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Elizabeth J. Cochran MD

Professor

Institution: Medical College of Wisconsin
Department: Pathology
Division: Administration

Member of the Cancer Center
Member of the Comprehensive Injury Center

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Publications

Acid ceramidase and its inhibitors: a drug target and a new class of drugs for killing glioblastoma cancer stem cells with high efficiency. (Doan NB, Alhajala H, Al-Gizawiy MM, Mueller WM, Rand SD, Connelly JM, Cochran EJ, Chitambar CR, Clark P, Kuo J, Schmainda KM, Mirza SP) Oncotarget 2017 Dec 22;8(68):112662-112674 PMID: 29348854 PMCID: PMC5762539 01/20/2018

Spatial discrimination of glioblastoma and treatment effect with histologically-validated perfusion and diffusion magnetic resonance imaging metrics. (Prah MA, Al-Gizawiy MM, Mueller WM, Cochran EJ, Hoffmann RG, Connelly JM, Schmainda KM) J Neurooncol 2018 Jan;136(1):13-21 PMID: 28900832 PMCID: PMC5756123 09/14/2017 3 Citations

Magnetic Resonance Imaging-Based Radiomic Profiles Predict Patient Prognosis in Newly Diagnosed Glioblastoma Before Therapy. (McGarry SD, Hurrell SL, Kaczmarowski AL, Cochran EJ, Connelly J, Rand SD, Schmainda KM, LaViolette PS) Tomography 2016 Sep;2(3):223-228 PMID: 27774518 PMCID: PMC5074084 10/25/2016

Spinal osteoblastic meningioma with hematopoiesis: radiologic-pathologic correlation and review of the literature. (Cochran EJ, Schlauderaff A, Rand SD, Eckardt GW, Kurpad S) Ann Diagn Pathol 2016 Oct;24:30-4 PMID: 27649951 09/22/2016

Extradural chondroma presenting as lumbar mass with compressive neuropathy. (Pace J, Lozen AM, Wang MC, Cochran EJ) J Craniovertebr Junction Spine 2014 Jul;5(3):131-3 PMID: 25336836 PMCID: PMC4201014 10/23/2014

Precise ex vivo histological validation of heightened cellularity and diffusion-restricted necrosis in regions of dark apparent diffusion coefficient in 7 cases of high-grade glioma. (LaViolette PS, Mickevicius NJ, Cochran EJ, Rand SD, Connelly J, Bovi JA, Malkin MG, Mueller WM, Schmainda KM) Neuro Oncol 2014 Dec;16(12):1599-606 PMID: 25059209 PMCID: PMC4232087 07/26/2014 28 Citations

Comprehensive characterization of glioblastoma tumor tissues for biomarker identification using mass spectrometry-based label-free quantitative proteomics. (Heroux MS, Chesnik MA, Halligan BD, Al-Gizawiy M, Connelly JM, Mueller WM, Rand SD, Cochran EJ, LaViolette PS, Malkin MG, Schmainda KM, Mirza SP) Physiol Genomics 2014 Jul 01;46(13):467-81 PMID: 24803679 PMCID: PMC4587597 05/08/2014 15 Citations

Moyamoya syndrome in an adult with essential thrombocythemia. (Lazzaro MA, Cochran EJ, Lopes DK, Prabhakaran S) Neurol Int 2011 Jun;3(1):e3 PMID: 21785675 PMCID: PMC3141114 07/26/2011

Temporal lobe pleomorphic xanthoastrocytoma and chronic epilepsy: long-term surgical outcomes. (Wallace DJ, Byrne RW, Ruban D, Cochran EJ, Roh D, Whisler WW) Clin Neurol Neurosurg 2011 Dec;113(10):918-22 PMID: 21741164 07/12/2011 9 Citations

Histopathologic description of Wingspan stent in acute ischemic stroke. (Lee VH, Samuels S, Herbst TJ, Gallegos M, Cochran EJ, Chen M, Prabhakaran S, Lopes DK) Neurocrit Care 2009 Dec;11(3):377-80 PMID: 19655277 08/06/2009 4 Citations

Chronic epilepsy associated with temporal tumors: long-term surgical outcome. (Ruban D, Byrne RW, Kanner A, Smith M, Cochran EJ, Roh D, Whisler WW) Neurosurg Focus 2009 Aug;27(2):E6 PMID: 19645562 08/04/2009 22 Citations

Protocol for the examination of specimens from patients with tumors of the brain/spinal cord. (Parisi JE, Miller DV, Boyer PJ, Brat DJ, Cochran EJ, Cohen ML, Demasters BK, Dolinak D, McComb RD, McLendon RE, Powell SZ, Prayson RA, Vinters HV, Yachnis AT, Members of Cancer Committee, College of American Pathologists) Arch Pathol Lab Med 2008 Jun;132(6):907-12 PMID: 18517271 06/04/2008 6 Citations

Malignant gliomas with primitive neuroectodermal tumor-like components: a clinicopathologic and genetic study of 53 cases. (Perry A, Miller CR, Gujrati M, Scheithauer BW, Zambrano SC, Jost SC, Raghavan R, Qian J, Cochran EJ, Huse JT, Holland EC, Burger PC, Rosenblum MK) Brain Pathol 2009 Jan;19(1):81-90 PMID: 18452568 05/03/2008 94 Citations

Postmortem study of deep brain stimulation of the anterior thalamus: case report. (Pilitsis JG, Chu Y, Kordower J, Bergen DC, Cochran EJ, Bakay RA) Neurosurgery 2008 Feb;62(2):E530-2; discussion E532 PMID: 18382294 04/03/2008 26 Citations

Decision rules guiding the clinical diagnosis of Alzheimer's disease in two community-based cohort studies compared to standard practice in a clinic-based cohort study. (Bennett DA, Schneider JA, Aggarwal NT, Arvanitakis Z, Shah RC, Kelly JF, Fox JH, Cochran EJ, Arends D, Treinkman AD, Wilson RS) Neuroepidemiology 2006;27(3):169-76 PMID: 17035694 10/13/2006 115 Citations

Vascular and Alzheimer-type pathology in an autopsy study of African-Americans. (Pytel P, Cochran EJ, Bonner G, Nyenhuis DL, Thomas C, Gorelick PB) Neurology 2006 Feb 14;66(3):433-5 PMID: 16476949 02/16/2006 7 Citations

Abundant neuritic inclusions and microvacuolar changes in a case of diffuse Lewy body disease with the A53T mutation in the alpha-synuclein gene. (Yamaguchi K, Cochran EJ, Murrell JR, Polymeropoulos MH, Shannon KM, Crowther RA, Goedert M, Ghetti B) Acta Neuropathol 2005 Sep;110(3):298-305 PMID: 15981014 06/28/2005 39 Citations

Tau epitope display in progressive supranuclear palsy and corticobasal degeneration. (Berry RW, Sweet AP, Clark FA, Lagalwar S, Lapin BR, Wang T, Topgi S, Guillozet-Bongaarts AL, Cochran EJ, Bigio EH, Binder LI) J Neurocytol 2004 May;33(3):287-95 PMID: 15475684 10/12/2004 29 Citations

Preservation of brain nerve growth factor in mild cognitive impairment and Alzheimer disease. (Mufson EJ, Ikonomovic MD, Styren SD, Counts SE, Wuu J, Leurgans S, Bennett DA, Cochran EJ, DeKosky ST) Arch Neurol 2003 Aug;60(8):1143-8 PMID: 12925373 08/20/2003 53 Citations

Relation of cerebral infarctions to dementia and cognitive function in older persons. (Schneider JA, Wilson RS, Cochran EJ, Bienias JL, Arnold SE, Evans DA, Bennett DA) Neurology 2003 Apr 08;60(7):1082-8 PMID: 12682310 04/12/2003 193 Citations

Cholinergic plasticity in hippocampus of individuals with mild cognitive impairment: correlation with Alzheimer's neuropathology. (Ikonomovic MD, Mufson EJ, Wuu J, Cochran EJ, Bennett DA, DeKosky ST) J Alzheimers Dis 2003 Feb;5(1):39-48 PMID: 12590165 02/19/2003 105 Citations

Apolipoprotein E epsilon4 allele, AD pathology, and the clinical expression of Alzheimer's disease. (Bennett DA, Wilson RS, Schneider JA, Evans DA, Aggarwal NT, Arnold SE, Cochran EJ, Berry-Kravis E, Bienias JL) Neurology 2003 Jan 28;60(2):246-52 PMID: 12552039 01/29/2003 176 Citations

Oligodendroglioma: pathology and molecular biology. (Engelhard HH, Stelea A, Cochran EJ) Surg Neurol 2002 Aug;58(2):111-7; discussion 117 PMID: 12453646 11/28/2002 67 Citations

An R5L tau mutation in a subject with a progressive supranuclear palsy phenotype. (Poorkaj P, Muma NA, Zhukareva V, Cochran EJ, Shannon KM, Hurtig H, Koller WC, Bird TD, Trojanowski JQ, Lee VM, Schellenberg GD) Ann Neurol 2002 Oct;52(4):511-6 PMID: 12325083 09/27/2002 140 Citations

Age-related decreases in Nurr1 immunoreactivity in the human substantia nigra. (Chu Y, Kompoliti K, Cochran EJ, Mufson EJ, Kordower JH) J Comp Neurol 2002 Aug 26;450(3):203-14 PMID: 12209851 09/05/2002 123 Citations

The apolipoprotein E epsilon 4 allele and decline in different cognitive systems during a 6-year period. (Wilson RS, Schneider JA, Barnes LL, Beckett LA, Aggarwal NT, Cochran EJ, Berry-Kravis E, Bach J, Fox JH, Evans DA, Bennett DA) Arch Neurol 2002 Jul;59(7):1154-60 PMID: 12117364 07/16/2002 172 Citations

Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease. (Mitchell TW, Mufson EJ, Schneider JA, Cochran EJ, Nissanov J, Han LY, Bienias JL, Lee VM, Trojanowski JQ, Bennett DA, Arnold SE) Ann Neurol 2002 Feb;51(2):182-9 PMID: 11835374 02/09/2002 181 Citations

Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment. (DeKosky ST, Ikonomovic MD, Styren SD, Beckett L, Wisniewski S, Bennett DA, Cochran EJ, Kordower JH, Mufson EJ) Ann Neurol 2002 Feb;51(2):145-55 PMID: 11835370 02/09/2002 543 Citations

Loss of basal forebrain P75(NTR) immunoreactivity in subjects with mild cognitive impairment and Alzheimer's disease. (Mufson EJ, Ma SY, Dills J, Cochran EJ, Leurgans S, Wuu J, Bennett DA, Jaffar S, Gilmor ML, Levey AI, Kordower JH) J Comp Neurol 2002 Feb 04;443(2):136-53 PMID: 11793352 01/17/2002 170 Citations

Pathological glial tau accumulations in neurodegenerative disease: review and case report. (Berry RW, Quinn B, Johnson N, Cochran EJ, Ghoshal N, Binder LI) Neurochem Int 2001 Nov-Dec;39(5-6):469-79 PMID: 11578782 10/02/2001 34 Citations

Down-regulation of trkA mRNA within nucleus basalis neurons in individuals with mild cognitive impairment and Alzheimer's disease. (Chu Y, Cochran EJ, Bennett DA, Mufson EJ, Kordower JH) J Comp Neurol 2001 Aug 27;437(3):296-307 PMID: 11494257 08/09/2001 62 Citations

Monomelic amyotrophy with late progression. (Rowin J, Meriggioli MN, Cochran EJ) Neuromuscul Disord 2001 Apr;11(3):305-8 PMID: 11297947 04/12/2001 16 Citations

HMG-CoA Reductase Inhibitor Myopathy: Clinical, Electrophysiological, and Pathologic Data in Five Patients. (Meriggioli MN, Barboi AC, Rowin J, Cochran EJ) J Clin Neuromuscul Dis 2001 Mar;2(3):129-34 PMID: 19078619 03/01/2001

Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment. (Kordower JH, Chu Y, Stebbins GT, DeKosky ST, Cochran EJ, Bennett D, Mufson EJ) Ann Neurol 2001 Feb;49(2):202-13 PMID: 11220740 02/28/2001 322 Citations

Novel method to quantify neuropil threads in brains from elders with or without cognitive impairment. (Mitchell TW, Nissanov J, Han LY, Mufson EJ, Schneider JA, Cochran EJ, Bennett DA, Lee VM, Trojanowski JQ, Arnold SE) J Histochem Cytochem 2000 Dec;48(12):1627-38 PMID: 11101631 12/02/2000 60 Citations

Loss of nucleus basalis neurons containing trkA immunoreactivity in individuals with mild cognitive impairment and early Alzheimer's disease. (Mufson EJ, Ma SY, Cochran EJ, Bennett DA, Beckett LA, Jaffar S, Saragovi HU, Kordower JH) J Comp Neurol 2000 Nov 06;427(1):19-30 PMID: 11042589 10/24/2000 191 Citations

Age-related decreases in GTP-cyclohydrolase-I immunoreactive neurons in the monkey and human substantia nigra. (Chen EY, Kallwitz E, Leff SE, Cochran EJ, Mufson EJ, Kordower JH, Mandel RJ) J Comp Neurol 2000 Oct 30;426(4):534-48 PMID: 11027397 10/12/2000 28 Citations

Giant anterior communicating artery aneurysm infiltrated with a primary cerebral lymphoma: case report. (Roitberg BZ, Cochran EJ, Thornton J, Charbel FT) Neurosurgery 2000 Aug;47(2):458-62 PMID: 10942022 08/15/2000 12 Citations

Prominent inflammatory changes on muscle biopsy in patients with Miyoshi myopathy. (Rowin J, Meriggioli MN, Cochran EJ, Sanders DB) Neuromuscul Disord 1999 Oct;9(6-7):417-20 PMID: 10545047 11/02/1999 32 Citations

A new molecular link between the fibrillar and granulovacuolar lesions of Alzheimer's disease. (Ghoshal N, Smiley JF, DeMaggio AJ, Hoekstra MF, Cochran EJ, Binder LI, Kuret J) Am J Pathol 1999 Oct;155(4):1163-72 PMID: 10514399 PMCID: PMC1867028 10/09/1999 98 Citations

Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease. (Kordower JH, Palfi S, Chen EY, Ma SY, Sendera T, Cochran EJ, Cochran EJ, Mufson EJ, Penn R, Goetz CG, Comella CD) Ann Neurol 1999 Sep;46(3):419-24 PMID: 10482276 09/11/1999 338 Citations

Preservation of nucleus basalis neurons containing choline acetyltransferase and the vesicular acetylcholine transporter in the elderly with mild cognitive impairment and early Alzheimer's disease. (Gilmor ML, Erickson JD, Varoqui H, Hersh LB, Bennett DA, Cochran EJ, Mufson EJ, Levey AI) J Comp Neurol 1999 Sep 06;411(4):693-704 PMID: 10421878 07/28/1999 202 Citations

Entorhinal cortex beta-amyloid load in individuals with mild cognitive impairment. (Mufson EJ, Chen EY, Cochran EJ, Beckett LA, Bennett DA, Kordower JH) Exp Neurol 1999 Aug;158(2):469-90 PMID: 10415154 07/23/1999 191 Citations

Dopamine transporter-immunoreactive neurons decrease with age in the human substantia nigra. (Ma SY, Ciliax BJ, Stebbins G, Jaffar S, Joyce JN, Cochran EJ, Kordower JH, Mash DC, Levey AI, Mufson EJ) J Comp Neurol 1999 Jun 21;409(1):25-37 PMID: 10363709 06/11/1999 109 Citations

Allelic origin of the abnormal prion protein isoform in familial prion diseases. (Chen SG, Parchi P, Brown P, Capellari S, Zou W, Cochran EJ, Vnencak-Jones CL, Julien J, Vital C, Mikol J, Lugaresi E, Autilio-Gambetti L, Gambetti P) Nat Med 1997 Sep;3(9):1009-15 PMID: 9288728 09/01/1997 77 Citations

Familial Creutzfeldt-Jakob disease with a five-repeat octapeptide insert mutation. (Cochran EJ, Bennett DA, Cervenáková L, Kenney K, Bernard B, Foster NL, Benson DF, Goldfarb LG, Brown P) Neurology 1996 Sep;47(3):727-33 PMID: 8797471 09/01/1996 55 Citations

Autopsy practices at CERAD and Alzheimer disease center sites: a survey of neuropathologists. (Cochran EJ, Gostanian OM, Mirra SS) Alzheimer Dis Assoc Disord 1995;9(4):203-7 PMID: 8749608 01/01/1995 6 Citations

White matter changes: neurobehavioral manifestations of Binswanger's disease and clinical correlates in Alzheimer's disease. (Bennett DA, Gilley DW, Lee S, Cochran EJ) Dementia 1994 May-Aug;5(3-4):148-52 PMID: 8087170 05/01/1994 34 Citations

Cerebrospinal fluid from patients with Parkinson's disease alters the survival of dopamine neurons in mesencephalic culture. (Yu SJ, Lo ES, Cochran EJ, Lin DH, Faselis CJ, Klawans HL, Carvey PM) Exp Neurol 1994 Mar;126(1):15-24 PMID: 7908885 03/01/1994

Severe panencephalic Pick's disease with Alzheimer's disease-like neuropil threads and synaptophysin immunoreactivity. (Cochran EJ, Fox JH, Mufson EJ) Acta Neuropathol 1994;88(5):479-84 PMID: 7847079 01/01/1994 24 Citations

Pathological changes in frontal cortex from biopsy to autopsy in Alzheimer's disease. (Bennett DA, Cochran EJ, Saper CB, Leverenz JB, Gilley DW, Wilson RS) Neurobiol Aging 1993 Nov-Dec;14(6):589-96 PMID: 8295661 11/01/1993 55 Citations

Transient global amnesia after cerebral angiography. Report of seven cases. (Cochran JW, Morrell F, Huckman MS, Cochran EJ) Arch Neurol 1982 Sep;39(9):593-4 PMID: 7115152 09/01/1982 29 Citations

Last update: 01/21/2018

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Profiles for MCW, MU, MSOE, UWM, BCW, CHW, Froedtert, and VA Faculty

Elizabeth J. Cochran MD

Professor

Publications