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George M. Hoffman MD

Chief, Professor

Institution: Medical College of Wisconsin
Department: Anesthesiology
Division: Pediatric Anesthesiology
Program: Pediatrics

image of /images/ORCIDiD_icon16x16.png https://orcid.org/0000-0001-6501-2940

Member of the Cardiovascular Center

I am willing to collaborate on research projects.
I am willing to mentor a junior faculty member.

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Publications (129)

Discussion to: Peri-operative exposure to volatile organic compounds in neonates undergoing cardiac surgery. (Gaynor, JW Hoffman, GM) Journal of Thoracic and Cardiovascular Surgery, 167(3), 1177–1178. 04/01/2024

Does anesthesia duration or number of cases per patient predict safety events? (Berens RJ, Greene CC, Frahm CE, McCormick ME, Hoffman GM) Paediatr Anaesth 2024 Jun;34(6):568-574 PMID: 38379426 SCOPUS ID: 2-s2.0-85186252007 02/21/2024

Hypoplastic Left Heart Syndrome (Tweddell JS, Hoffman GM, Wells DA, Ghanayem NS, Winlaw DS.) Sabiston and Spencer Surgery of the Chest 10th edition 2024. Frank Sellke, Pedro J. del Nido, Scott J. Swanson eds. Elsevier, Philadelphia 12/10/2023

Does High-Intensity Exercise Cause Acute Liver Injury in Patients with Fontan Circulation? A Prospective Pilot Study. (Gumm A, Ginde S, Hoffman G, Liegl M, Mack C, Simpson P, Vo N, Telega G, Vitola B, Chugh A) Pediatr Cardiol 2023 May 23 PMID: 37219588 SCOPUS ID: 2-s2.0-85160257265 05/23/2023

Mathematical analysis of hemoglobin target in univentricular parallel circulation. (Ahmed M, Acosta SI, Hoffman GM, Tweddell JS, Ghanayem NS) J Thorac Cardiovasc Surg 2023 Jul;166(1):214-220 PMID: 36357224 SCOPUS ID: 2-s2.0-85142396786 11/11/2022 3 Citations

Nuclear Cell-Free DNA Predicts Adverse Events After Pediatric Cardiothoracic Surgery. (Tanem JM, Scott JP, Hoffman GM, Niebler RA, Tomita-Mitchell A, Stamm KD, Liang HL, North PE, Bertrandt RA, Woods RK, Hraska V, Mitchell ME) Ann Thorac Surg 2023 Aug;116(2):349-356 PMID: 36332680 SCOPUS ID: 2-s2.0-85150823960 11/05/2022 1 Citation

Impact of Reintervention During Stage 1 Palliation Hospitalization: A National, Multicenter Study. (Handler SS, Chan T, Ghanayem NS, Rudd N, Wright G, Visotcky A, Sparapani R, Mitchell ME, Hoffman GM, Frommelt MA) Ann Thorac Surg 2023 Apr;115(4):975-981 PMID: 36306859 SCOPUS ID: 2-s2.0-85142376895 10/29/2022 1 Citation

Intranasal dexmedetomidine for transthoracic echocardiography in infants with shunt-dependent single ventricle heart disease. (Ellepola CD, Handler SS, Frommelt M, Saudek DE, Scott J, Hoffman G, Frommelt PC) Cardiol Young 2023 Aug;33(8):1327-1331 PMID: 35938539 SCOPUS ID: 2-s2.0-85169651954 08/09/2022

Cumulative comorbid conditions influence mortality risk after staged palliation for hypoplastic left heart syndrome and variants. (Backes ER, Afonso NS, Guffey D, Tweddell JS, Tabbutt S, Rudd NA, O'Harrow G, Molossi S, Hoffman GM, Hill G, Heinle JS, Bhat P, Anderson JB, Ghanayem NS) J Thorac Cardiovasc Surg 2023 Jan;165(1):287-298.e4 PMID: 35599210 SCOPUS ID: 2-s2.0-85125715823 05/23/2022 4 Citations

Effects of Arterial Carbon Dioxide Tension on Cerebral and Somatic Regional Tissue Oxygenation and Blood Flow in Neonates After the Norwood Procedure With Deep Hypothermic Cardiopulmonary Bypass. (Hoffman GM, Scott JP, Stuth EA) Front Pediatr 2022;10:762739 PMID: 35223690 PMCID: PMC8873518 SCOPUS ID: 2-s2.0-85125176905 03/01/2022 1 Citation

Elevated nuclear and mitochondrial cell-free deoxyribonucleic acid measurements are associated with death after infant cardiac surgery. (Scott JP, Tanem JM, Tomita-Mitchell A, Hoffman GM, Niebler RA, Liang HL, Simpson PM, Stamm KD, North PE, Mitchell ME) J Thorac Cardiovasc Surg 2022 Aug;164(2):367-375 PMID: 35144816 SCOPUS ID: 2-s2.0-85120861361 02/12/2022 4 Citations

COVID-19 pre-procedural testing strategy and early outcomes at a large tertiary care children's hospital. (Bence CM, Jarzembowski JA, Belter L, Berens RJ, Henrickson KJ, Hoffman GM, Jackson F, Kehl KS, Oldham KT, Scott JP, Tassone JC, Woger N, Yale E, Gourlay DM) Pediatr Surg Int 2021 Jul;37(7):871-880 PMID: 33715083 PMCID: PMC7955904 SCOPUS ID: 2-s2.0-85102600575 03/15/2021 6 Citations

Hypoplastic Left Heart Syndrome (Tweddell JS, Hoffman GM, Ghanayem NS, Frommelt MA, Mussatto KA, Berser S) Moss & Adam’s Heart Disease in Infants, Children, and Adolescents: Including the Fetus and Young Adult, 10e, eds. Robert E. Shaddy, Daniel J. Penny, Timothy F. Feltes, Frank Cetta, Seema Mital, Wolters Kluwer 08/16/2020

Interventions Associated With Treatment of Low Cardiac Output After Stage 1 Norwood Palliation. (Hoffman GM, Niebler RA, Scott JP, Bertrandt RA, Wakeham MK, Thompson NE, Ghanayem NS, Stuth EA, Mitchell ME, Woods RK, Hraska V, Mussatto KA, Tweddell JS) Ann Thorac Surg 2021 May;111(5):1620-1627 PMID: 32652068 SCOPUS ID: 2-s2.0-85095846624 07/12/2020 13 Citations

Innominate Vein Turn-down Procedure for Failing Fontan Circulation. (Hraska V, Mitchell ME, Woods RK, Hoffman GM, Kindel SJ, Ginde S) Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2020;23:34-40 PMID: 32354545 SCOPUS ID: 2-s2.0-85080101619 05/02/2020 15 Citations

Changes in Health Care Utilization for Pediatric Patients Treated at a Specialized Outpatient Pain Clinic. (Spector A, Brazauskas R, Hainsworth K, Hoffman GM, Weisman S, Cassidy LD) WMJ 2019 Dec;118(4):164-168 PMID: 31978284 SCOPUS ID: 2-s2.0-85078228471 01/25/2020 1 Citation

Identification of Time-Dependent Risks of Hemodynamic States After Stage 1 Norwood Palliation. (Hoffman GM, Scott JP, Ghanayem NS, Stuth EA, Mitchell ME, Woods RK, Hraska V, Niebler RA, Bertrandt RA, Mussatto KA, Tweddell JS) Ann Thorac Surg 2020 Jan;109(1):155-162 PMID: 31404548 SCOPUS ID: 2-s2.0-85075400764 08/14/2019 15 Citations

Norwood Procedure-Difficulty in Weaning From Cardiopulmonary Bypass and Implications for Outcomes. (Gellings JA, Johnson WK, Ghanayem NS, Mitchell M, Tweddell J, Hoffman G, Hraska V, Kuhn EM, Woods RK) Semin Thorac Cardiovasc Surg 2020;32(1):119-125 PMID: 31404609 PMCID: PMC7007819 SCOPUS ID: 2-s2.0-85071455853 08/14/2019 2 Citations

Safety and Efficacy of Vasopressin After Fontan Completion: A Randomized Pilot Study. (Bigelow AM, Ghanayem NS, Thompson NE, Scott JP, Cassidy LD, Woods KJ, Woods RK, Mitchell ME, Hraŝka V, Hoffman GM) Ann Thorac Surg 2019 Dec;108(6):1865-1874 PMID: 31400337 PMCID: PMC9553092 SCOPUS ID: 2-s2.0-85074440821 08/11/2019 11 Citations

Surgical Techniques (Bryant R, Reagor JA, Hoffman GM, Tweddell JS) Anderson's Pediatric Cardiology 4th Edition, ed.G Wernovsky, RH Anderson, K Kumar, K Mussatto, AN Redington, JS Tweddell, JT Tretter, Elsevier, 2020 07/12/2019

Monitoring Systems (Ghanayem-NS, Ahmed-M, Anders-MM, Tume-SC, Yu-EL, Hoffman-GM.) Critical Heart Disease in Infants and Children, 3rd Edition, 22, 245-260.e5, ed. RM Ungerleider, JN Meliones, K Nelson McMillan, DS Cooper, JP Jacobs, Elsevier, 2019 01/17/2019

Transabdominal Intrapericardial Approach in Liver Transplantation for Unresectable Primary Hepatic Functioning Paraganglioma With Invasion Into Hepatic Veins and Suprahepatic Vena Cava: A Surgical and Anesthesia Management Challenge. (Kim J, Fons RA, Scott JP, Eriksen CM, Lerret SM, Browning MB, Telega GW, Vitola BE, Hoffman GM, North PE, Vo NN, Zimmerman MA, Hong JC) Transplant Proc 2018 Nov;50(9):2630-2635 PMID: 30401364 SCOPUS ID: 2-s2.0-85055872814 11/08/2018 2 Citations

Staged biliary reconstruction after liver transplantation: A novel surgical strategy for high acuity pediatric transplant recipients. (Kim J, Zimmerman MA, Lerret SM, Scott JP, Voulgarelis S, Fons RA, Vitola BE, Telega GW, Hoffman GM, Berens RJ, Hong JC) Surgery 2019 Feb;165(2):323-328 PMID: 30268374 SCOPUS ID: 2-s2.0-85053863845 10/01/2018 5 Citations

Uh-oh, some CO₂ has gone missing. (Woods RK, Hoffman GH) J Thorac Cardiovasc Surg 2018 Sep;156(3):1179-1180 PMID: 29958662 SCOPUS ID: 2-s2.0-85048968360 07/01/2018

Central ECMO for circulatory failure following pediatric liver transplantation. (Scott JP, Hong JC, Thompson NE, Woods RK, Hoffman GM) Perfusion 2018 Nov;33(8):704-706 PMID: 29788811 SCOPUS ID: 2-s2.0-85047387016 05/24/2018 5 Citations

Impact of Anticoagulation and Circuit Technology on Complications During Extracorporeal Membrane Oxygenation. (Niebler RA, Parker H, Hoffman GM) ASAIO J 2019;65(3):270-276 PMID: 29746314 SCOPUS ID: 2-s2.0-85059984792 05/11/2018 28 Citations

Cardiopulmonary Resuscitation in Infants and Children With Cardiac Disease: A Scientific Statement From the American Heart Association. (Marino BS, Tabbutt S, MacLaren G, Hazinski MF, Adatia I, Atkins DL, Checchia PA, DeCaen A, Fink EL, Hoffman GM, Jefferies JL, Kleinman M, Krawczeski CD, Licht DJ, Macrae D, Ravishankar C, Samson RA, Thiagarajan RR, Toms R, Tweddell J, Laussen PC, American Heart Association Congenital Cardiac Defects Committee of the Council on Cardiovascular Disease in the Young; Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Surgery and Anesthesia; and Emergency Cardiovascular Care Committee) Circulation 2018 May 29;137(22):e691-e782 PMID: 29685887 SCOPUS ID: 2-s2.0-85048758877 04/25/2018 114 Citations

Monitoring systems (Ghanayem NS, Ahmed M, Anders MM, Tume SC, Vu EL, Hoffman GM) Critical Heart Disease in Infants and Children 1 January 2018:245-260.e5 SCOPUS ID: 2-s2.0-85082272071 01/01/2018

Hypoplastic Left Heart Syndrome (Chapter 46). (Tweddell JS, Hoffman GM, Ghanayem NS, Frommelt MA, Mussatto KA, Berger S.) Moss and Adams’ Heart Disease in Infants, Children, and Adolescents: Including the Fetus and Young Adult, 9th Edition, ed. HD Allen. Lippincott Williams & Wilkins, Baltimore, MD 2016. 06/30/2017

Postoperative Cerebral and Somatic Near-Infrared Spectroscopy Saturations and Outcome in Hypoplastic Left Heart Syndrome. (Hoffman GM, Ghanayem NS, Scott JP, Tweddell JS, Mitchell ME, Mussatto KA) Ann Thorac Surg 2017 May;103(5):1527-1535 PMID: 28012642 SCOPUS ID: 2-s2.0-85008153137 12/26/2016 82 Citations

Near Infrared Spectroscopy as a Hemodynamic Monitor in Critical Illness. (Ghanayem NS, Hoffman GM) Pediatr Crit Care Med 2016 Aug;17(8 Suppl 1):S201-6 PMID: 27490600 SCOPUS ID: 2-s2.0-84984629869 08/05/2016 56 Citations

Management of a Patient With Tetralogy of Fallot, Congenital Diaphragmatic Hernia, and Complete Left Lung Agenesis. (Labovsky K, Hoffman G, Scott J) A A Case Rep 2016 Jul 01;7(1):16-20 PMID: 27258177 SCOPUS ID: 2-s2.0-85021851271 06/04/2016 2 Citations

Hypoplastic left heart syndrome (Tweddell JS, Hoffman GM, Ghanayem NS, Frommelt MA, Mussatto KA, Berger S) Moss and Adams' Heart Disease in Infants, Children, and Adolescents: Including the Fetus and Young Adult: Ninth Edition 2 February 2016;2 SCOPUS ID: 2-s2.0-84974824292 02/02/2016 3 Citations

A Pilot Study of Antithrombin Replacement Prior to Cardiopulmonary Bypass in Neonates. (Niebler RA, Woods KJ, Murkowski K, Ghanayem NS, Hoffman G, Mitchell ME, Punzalan RC, Scott JP, Simpson P, Tweddell JS) Artif Organs 2016 Jan;40(1):80-5 PMID: 26620919 SCOPUS ID: 2-s2.0-84956825530 12/02/2015 9 Citations

Effect of Intercurrent Operation and Cerebral Oxygenation on Developmental Trajectory in Congenital Heart Disease. (Hoffman GM, Brosig CL, Bear LM, Tweddell JS, Mussatto KA) Ann Thorac Surg 2016 Feb;101(2):708-16 PMID: 26542436 SCOPUS ID: 2-s2.0-84953326663 11/07/2015 22 Citations

In Response. (Taylor SP, Hoffman GM) Anesth Analg 2015 Nov;121(5):1402-3 PMID: 26484473 SCOPUS ID: 2-s2.0-84954204485 10/21/2015

Risk Factors for Abnormal Developmental Trajectories in Young Children With Congenital Heart Disease. (Mussatto KA, Hoffmann R, Hoffman G, Tweddell JS, Bear L, Cao Y, Tanem J, Brosig C) Circulation 2015 Aug 25;132(8):755-61 PMID: 26304667 PMCID: PMC4551137 SCOPUS ID: 2-s2.0-84940640133 08/26/2015 73 Citations

Gas analysis using Raman spectroscopy demonstrates the presence of intraperitoneal air (nitrogen and oxygen) in a cohort of children undergoing pediatric laparoscopic surgery. (Taylor SP, Sato TT, Balcom AH, Groth T, Hoffman GM) Anesth Analg 2015 Feb;120(2):349-54 PMID: 25602452 SCOPUS ID: 2-s2.0-84921966763 01/21/2015 7 Citations

Increased recombinant activated factor VII use and need for surgical reexploration following a switch from aprotinin to epsilon-aminocaproic acid in infant cardiac surgery. (Scott JP, Costigan DJ, Hoffman GM, Simpson PM, Dasgupta M, Punzalan R, Berens RJ, Tweddell JS, Stuth EA) J Clin Anesth 2014 May;26(3):204-11 PMID: 24809789 SCOPUS ID: 2-s2.0-84901652434 05/09/2014 13 Citations

All this monitoring…what's necessary, what's not? (Tweddell JS, Ghanayem NS, Hoffman GM) Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2014;17(1):81-90 PMID: 24725722 SCOPUS ID: 2-s2.0-84897950584 04/15/2014 9 Citations

Risk and prevalence of developmental delay in young children with congenital heart disease. (Mussatto KA, Hoffmann RG, Hoffman GM, Tweddell JS, Bear L, Cao Y, Brosig C) Pediatrics 2014 Mar;133(3):e570-7 PMID: 24488746 PMCID: PMC3934337 SCOPUS ID: 2-s2.0-84895110339 02/04/2014 174 Citations

Non-invasive monitoring of oxygen delivery (Hoffman GM, Ghanayem NS, Tweddell JS) Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care 1 January 2014:835-855 SCOPUS ID: 2-s2.0-84953777467 01/01/2014 4 Citations

Changes in cerebral oxygen saturation correlate with S100B in infants undergoing cardiac surgery with cardiopulmonary bypass. (Abu-Sultaneh S, Hehir DA, Murkowski K, Ghanayem NS, Liedel J, Hoffmann RG, Cao Y, Mitchell ME, Jeromin A, Tweddell JS, Hoffman GM) Pediatr Crit Care Med 2014 Mar;15(3):219-28 PMID: 24366505 SCOPUS ID: 2-s2.0-84896398976 12/25/2013 23 Citations

Near-infrared spectroscopy: exposing the dark (venous) side of the circulation. (Scott JP, Hoffman GM) Paediatr Anaesth 2014 Jan;24(1):74-88 PMID: 24267637 SCOPUS ID: 2-s2.0-84890735183 11/26/2013 93 Citations

Resuscitation of the patient with the functionally univentricular heart (Marino BS, Tibby SM, Hoffman GM) Current Pediatric Reviews 2013;9(2):148-157 SCOPUS ID: 2-s2.0-84881511032 08/20/2013 6 Citations

Hypoplastic left heart syndrome (Tweddell JS, Hoffman GM, Ghanayem NS, Frommelt MA, Mussatto KA, Berger S) Moss and Adams' Heart Disease in Infants, Children, and Adolescents: Including the Fetus and Young Adult: Eighth Edition 30 May 2013;2-2 SCOPUS ID: 2-s2.0-84973113868 05/30/2013 5 Citations

Neurodevelopmental outcomes for children with hypoplastic left heart syndrome at the age of 5 years. (Brosig C, Mussatto K, Hoffman G, Hoffmann RG, Dasgupta M, Tweddell J, Ghanayem N) Pediatr Cardiol 2013 Oct;34(7):1597-604 PMID: 23503929 PMCID: PMC3982227 SCOPUS ID: 2-s2.0-84885383086 03/19/2013 44 Citations

Infant cardiac magnetic resonance imaging using oscillatory ventilation: safe and effective. (Chaves AH, Cava JR, Simpson P, Hoffman GM, Samyn MM) Pediatr Cardiol 2013 Jun;34(5):1201-5 PMID: 23344894 SCOPUS ID: 2-s2.0-84878017270 01/25/2013 3 Citations

Perioperative cerebral oxygen saturation in neonates with hypoplastic left heart syndrome and childhood neurodevelopmental outcome. (Hoffman GM, Brosig CL, Mussatto KA, Tweddell JS, Ghanayem NS) J Thorac Cardiovasc Surg 2013 Nov;146(5):1153-64 PMID: 23317941 SCOPUS ID: 2-s2.0-84885918741 01/16/2013 108 Citations

Resuscitation of the patient with the functionally univentricular heart. (Marino BS, Tibby SM, Hoffman GM) Curr Pediatr Rev 2013;9(2):148-57 PMID: 25417036 SCOPUS ID: 2-s2.0-84881511032 01/01/2013 6 Citations

Regional blood flow monitoring in the perioperative period (Hoffman GM, Tweddell JS) Hemodynamics and Cardiology 2012:473-487 SCOPUS ID: 2-s2.0-84882494892 12/01/2012 2 Citations

Regional Blood Flow Monitoring in the Perioperative Period (Hoffman GM, Tweddell JS) Hemodynamics and Cardiology: Neonatology Questions and Controversies Expert Consult - Online and Print 29 March 2012:473-487 SCOPUS ID: 2-s2.0-85133560746 03/29/2012

Infant cardiac MRI using oscillatory ventilation: safe and effective. (Chaves AH, Hoffman GM, Cava J, Simpson P, Samyn M) J Cardiovasc Magn Reson 2012 Feb 1;14 Suppl 1:P122 PMID: 22376615 03/02/2012

Near-infrared spectroscopic monitoring during cardiopulmonary exercise testing detects anaerobic threshold. (Rao RP, Danduran MJ, Loomba RS, Dixon JE, Hoffman GM) Pediatr Cardiol 2012 Jun;33(5):791-6 PMID: 22349729 SCOPUS ID: 2-s2.0-84863984523 02/22/2012 13 Citations

Creation and implementation of a prospective pediatric clinical outcomes registry. (Cassidy LD, Jensen JN, Durkee CT, Calkins CM, Sato T, Tassone C, Kerschner J, Theilke RJ, Mitchell ME, Hoffman GM, Oldham KT) J Registry Manag 2011;38(3):138-43 PMID: 22223056 SCOPUS ID: 2-s2.0-84863243093 01/10/2012 4 Citations

Near-infrared spectroscopy as a hemodynamic monitor in critical illness. (Ghanayem NS, Wernovsky G, Hoffman GM) Pediatr Crit Care Med 2011 Jul;12(4 Suppl):S27-32 PMID: 22129547 SCOPUS ID: 2-s2.0-79959976707 01/04/2012 94 Citations

A sisyphean task: identifying physiologic risk and improving outcomes in complex congenital heart surgery. (Stuth EA, Hoffman GM) Anesthesiology 2011 Nov;115(5):926-8 PMID: 21934483 SCOPUS ID: 2-s2.0-80055010197 09/22/2011

Aortic exclusion: a method of handling aortic insufficiency in the pediatric population needing mechanical circulatory support. (Gandy KL, Mitchell ME, Pelech AN, Niebler RA, Hoffman G, Berger S) Pediatr Cardiol 2011 Dec;32(8):1231-3 PMID: 21809133 SCOPUS ID: 2-s2.0-83555165034 08/03/2011 7 Citations

The effect of caudal vs intravenous morphine on early extubation and postoperative analgesic requirements for stage 2 and 3 single-ventricle palliation: a double blind randomized trial. (Stuth EA, Berens RJ, Staudt SR, Robertson FA, Scott JP, Stucke AG, Hoffman GM, Troshynski TJ, Tweddell JS, Zuperku EJ) Paediatr Anaesth 2011 Apr;21(4):441-53 PMID: 21306473 SCOPUS ID: 2-s2.0-79952471592 02/11/2011 20 Citations

Occurrence of a carbon dioxide embolism during laparoscopic pyloromyotomy in a small child: several unresolved questions. (Fischler M) Can J Anaesth 2011 Feb;58(2):226; author reply 226-7 PMID: 21132476 SCOPUS ID: 2-s2.0-79951717150 12/07/2010 4 Citations

Surgical techniques (Gandy KL, Hoffman GM, Vanderwal P, Tweddell JS) Paediatric Cardiology 2010:219-237 SCOPUS ID: 2-s2.0-84882809846 12/01/2010

Part 10: Pediatric basic and advanced life support: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. (Kleinman ME, de Caen AR, Chameides L, Atkins DL, Berg RA, Berg MD, Bhanji F, Biarent D, Bingham R, Coovadia AH, Hazinski MF, Hickey RW, Nadkarni VM, Reis AG, Rodriguez-Nunez A, Tibballs J, Zaritsky AL, Zideman D, Pediatric Basic and Advanced Life Support Chapter Collaborators) Circulation 2010 Oct 19;122(16 Suppl 2):S466-515 PMID: 20956258 PMCID: PMC3748977 SCOPUS ID: 2-s2.0-78149267035 10/22/2010 177 Citations

Pediatric basic and advanced life support: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. (Kleinman ME, de Caen AR, Chameides L, Atkins DL, Berg RA, Berg MD, Bhanji F, Biarent D, Bingham R, Coovadia AH, Hazinski MF, Hickey RW, Nadkarni VM, Reis AG, Rodriguez-Nunez A, Tibballs J, Zaritsky AL, Zideman D, Pediatric Basic and Advanced Life Support Chapter Collaborators) Pediatrics 2010 Nov;126(5):e1261-318 PMID: 20956433 PMCID: PMC3784274 SCOPUS ID: 2-s2.0-78049448034 10/20/2010 63 Citations

Perioperative neuromonitoring in pediatric cardiac surgery: Techniques and targets (Hoffman GM, Ghanayem NS) Progress in Pediatric Cardiology August 2010;29(2):123-130 SCOPUS ID: 2-s2.0-77955317026 08/01/2010 17 Citations

Perioperative neuromonitoring in pediatric cardiac surgery: Techniques and targets (Hoffman GM, Ghanayem NS ) Progress in Pediatric Cardiology Volume 29, Issue 2, August 2010, Pages 123–130 07/20/2010

Perioperative monitoring in high-risk infants after stage 1 palliation of univentricular congenital heart disease. (Ghanayem NS, Hoffman GM, Mussatto KA, Frommelt MA, Cava JR, Mitchell ME, Tweddell JS) J Thorac Cardiovasc Surg 2010 Oct;140(4):857-63 PMID: 20621312 SCOPUS ID: 2-s2.0-77956885774 07/14/2010 70 Citations

Cerebral and somatic near-infrared spectroscopy in normal newborns. (Bernal NP, Hoffman GM, Ghanayem NS, Arca MJ) J Pediatr Surg 2010 Jun;45(6):1306-10 PMID: 20620336 SCOPUS ID: 2-s2.0-77953837168 07/14/2010 100 Citations

Gas embolus and cardiac arrest during laparoscopic pyloromyotomy in an infant. (Taylor SP, Hoffman GM) Can J Anaesth 2010 Aug;57(8):774-8 PMID: 20431981 SCOPUS ID: 2-s2.0-77955470273 05/01/2010 26 Citations

Pro: NIRS is "standard of care" for postoperative management. (Tweddell JS, Ghanayem NS, Hoffman GM) Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2010;13(1):44-50 PMID: 20307860 SCOPUS ID: 2-s2.0-77949621537 03/24/2010 75 Citations

Cerebral hemodynamics in the presence of decreased systemic venous compliance in patients with Fontan physiology may limit anaerobic exercise capacity. (Rao RP, Danduran MJ, Hoffman GM, Ghanayem NS, Berger S, Frommelt PC) Pediatr Cardiol 2010 Feb;31(2):208-14 PMID: 19915888 SCOPUS ID: 2-s2.0-77952315740 11/17/2009 16 Citations

Fontan palliation in the modern era: factors impacting mortality and morbidity. (Tweddell JS, Nersesian M, Mussatto KA, Nugent M, Simpson P, Mitchell ME, Ghanayem NS, Pelech AN, Marla R, Hoffman GM) Ann Thorac Surg 2009 Oct;88(4):1291-9 PMID: 19766824 SCOPUS ID: 2-s2.0-70349188689 09/22/2009 142 Citations

Hypersensitivity reactions to aprotinin re-exposure in paediatric surgery. (Siehr S, Stuth E, Tweddell J, Hoffman G, Troshynski T, Jones D, Mitchell M, Ghanayem N) Eur J Cardiothorac Surg 2010 Feb;37(2):307-11 PMID: 19767215 SCOPUS ID: 2-s2.0-74249101769 09/22/2009 9 Citations

Effect of volume resuscitation on regional perfusion in dehydrated pediatric patients as measured by two-site near-infrared spectroscopy. (Hanson SJ, Berens RJ, Havens PL, Kim MK, Hoffman GM) Pediatr Emerg Care 2009 Mar;25(3):150-3 PMID: 19262423 SCOPUS ID: 2-s2.0-66249100245 03/06/2009 52 Citations

Measurement of regional tissue bed venous weighted oximetric trends during exercise by near infrared spectroscopy. (Rao RP, Danduran MJ, Frommelt PC, Ghanayem NS, Berger S, Simpson PM, Yan K, Hoffman GM) Pediatr Cardiol 2009 May;30(4):465-71 PMID: 19225827 SCOPUS ID: 2-s2.0-67349247662 02/20/2009 14 Citations

Near-infrared spectroscopy in neonates before palliation of hypoplastic left heart syndrome. (Johnson BA, Hoffman GM, Tweddell JS, Cava JR, Basir M, Mitchell ME, Scanlon MC, Mussatto KA, Ghanayem NS) Ann Thorac Surg 2009 Feb;87(2):571-7; discussion 577-9 PMID: 19161781 SCOPUS ID: 2-s2.0-58249137786 01/24/2009 84 Citations

Outcomes of pediatric anesthesia. (Hoffman GM) Semin Pediatr Surg 2008 May;17(2):141-51 PMID: 18395664 SCOPUS ID: 2-s2.0-41449092994 04/09/2008 16 Citations

Cardiopulmonary resuscitation: special considerations for infants and children with cardiac disease. (Peddy SB, Hazinski MF, Laussen PC, Thiagarajan RR, Hoffman GM, Nadkarni V, Tabbutt S) Cardiol Young 2007 Sep;17 Suppl 2:116-26 PMID: 18039405 SCOPUS ID: 2-s2.0-36948998764 02/23/2008 40 Citations

Mixed venous oxygen saturation monitoring after stage 1 palliation for hypoplastic left heart syndrome. (Tweddell JS, Ghanayem NS, Mussatto KA, Mitchell ME, Lamers LJ, Musa NL, Berger S, Litwin SB, Hoffman GM) Ann Thorac Surg 2007 Oct;84(4):1301-10; discussion 1310-1 PMID: 17888987 SCOPUS ID: 2-s2.0-34548661975 09/25/2007 132 Citations

Effect of shunt type on echocardiographic indices after initial palliations for hypoplastic left heart syndrome: Blalock-Taussig shunt versus right ventricle-pulmonary artery conduit. (Frommelt PC, Sheridan DC, Mussatto KA, Hoffman GM, Ghanayem NS, Frommelt MA, Tweddell JS) J Am Soc Echocardiogr 2007 Dec;20(12):1364-73 PMID: 17604955 SCOPUS ID: 2-s2.0-36549019972 07/03/2007 43 Citations

Monitoring the brain before, during, and after cardiac surgery to improve long-term neurodevelopmental outcomes. (Ghanayem NS, Mitchell ME, Tweddell JS, Hoffman GM) Cardiol Young 2006 Sep;16 Suppl 3:103-9 PMID: 17378048 SCOPUS ID: 2-s2.0-33750214288 03/23/2007 29 Citations

Right ventricle-to-pulmonary artery conduit versus Blalock-Taussig shunt: a hemodynamic comparison. (Ghanayem NS, Jaquiss RD, Cava JR, Frommelt PC, Mussatto KA, Hoffman GM, Tweddell JS) Ann Thorac Surg 2006 Nov;82(5):1603-9; discussion 1609-10 PMID: 17062213 SCOPUS ID: 2-s2.0-33750038858 10/26/2006 65 Citations

Early cavopulmonary anastomosis after Norwood procedure results in excellent Fontan outcome. (Jaquiss RD, Siehr SL, Ghanayem NS, Hoffman GM, Fedderly RT, Cava JR, Mussatto KA, Tweddell JS) Ann Thorac Surg 2006 Oct;82(4):1260-5; discussion 1265-6 PMID: 16996918 SCOPUS ID: 2-s2.0-33748748733 09/26/2006 41 Citations

Pro: near-infrared spectroscopy should be used for all cardiopulmonary bypass. (Hoffman GM) J Cardiothorac Vasc Anesth 2006 Aug;20(4):606-12 PMID: 16884998 SCOPUS ID: 2-s2.0-33746349282 08/04/2006 56 Citations

Assent for treatment: clinician knowledge, attitudes, and practice. (Lee KJ, Havens PL, Sato TT, Hoffman GM, Leuthner SR) Pediatrics 2006 Aug;118(2):723-30 PMID: 16882829 SCOPUS ID: 2-s2.0-33748415225 08/03/2006 45 Citations

Near infrared spectroscopy monitoring during pediatric aortic coarctation repair. (Berens RJ, Stuth EA, Robertson FA, Jaquiss RD, Hoffman GM, Troshynski TJ, Staudt SR, Cava JR, Tweddell JS, Bert Litwin S) Paediatr Anaesth 2006 Jul;16(7):777-81 PMID: 16879521 SCOPUS ID: 2-s2.0-33748347887 08/02/2006 53 Citations

Neurologic monitoring on cardiopulmonary bypass: what are we obligated to do? (Hoffman GM) Ann Thorac Surg 2006 Jun;81(6):S2373-80 PMID: 16731106 SCOPUS ID: 2-s2.0-33646849248 05/30/2006 68 Citations

A prospective evaluation of opioid weaning in opioid-dependent pediatric critical care patients. (Berens RJ, Meyer MT, Mikhailov TA, Colpaert KD, Czarnecki ML, Ghanayem NS, Hoffman GM, Soetenga DJ, Nelson TJ, Weisman SJ) Anesth Analg 2006 Apr;102(4):1045-50 PMID: 16551896 SCOPUS ID: 2-s2.0-33645506922 03/23/2006 72 Citations

Optimal timing of the second stage of palliation for hypoplastic left heart syndrome facilitated through home monitoring, and the results of early cavopulmonary anastomosis. (Ghanayem NS, Tweddell JS, Hoffman GM, Mussatto K, Jaquiss RD. ) Cardiology in the Young Cardiol Young. 2006 Feb;16 Suppl 1:61-6. 02/16/2006

Mean airway pressure and response to inhaled nitric oxide in neonatal and pediatric patients. (Hoffman GM, Nelin LD) Lung 2005;183(6):441-53 PMID: 16465603 SCOPUS ID: 2-s2.0-32244435691 02/09/2006 8 Citations

Optimal timing of the second stage of palliation for hypoplastic left heart syndrome facilitated through home monitoring, and the results of early cavopulmonary anastomosis. (Ghanayem NS, Tweddell JS, Hoffman GM, Mussatto K, Jaquiss RD) Cardiol Young 2006 Feb;16 Suppl 1:61-6 PMID: 16401365 SCOPUS ID: 2-s2.0-33646192383 01/13/2006 77 Citations

Systemic venous oxygen saturation after the Norwood procedure and childhood neurodevelopmental outcome. (Hoffman GM, Mussatto KA, Brosig CL, Ghanayem NS, Musa N, Fedderly RT, Jaquiss RD, Tweddell JS) J Thorac Cardiovasc Surg 2005 Oct;130(4):1094-100 PMID: 16214525 SCOPUS ID: 2-s2.0-26444457270 10/11/2005 129 Citations

Survival after treatment of rabies with induction of coma. (Willoughby RE Jr, Tieves KS, Hoffman GM, Ghanayem NS, Amlie-Lefond CM, Schwabe MJ, Chusid MJ, Rupprecht CE) N Engl J Med 2005 Jun 16;352(24):2508-14 PMID: 15958806 SCOPUS ID: 2-s2.0-20444444376 06/17/2005 493 Citations

Detection and prevention of neurologic injury in the intensive care unit. (Hoffman GM) Cardiol Young 2005 Feb;15 Suppl 1:149-53 PMID: 15934708 SCOPUS ID: 2-s2.0-21844441189 06/07/2005 17 Citations

Aortic valve repair. (Tweddell JS, Pelech AN, Jaquiss RD, Frommelt PC, Mussatto KA, Hoffman GM, Litwin SB) Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2005:112-21 PMID: 15818366 SCOPUS ID: 2-s2.0-16444378736 04/09/2005 19 Citations

Noninvasive assessment of cardiac output. (Hoffman GM, Ghanayem NS, Tweddell JS) Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2005:12-21 PMID: 15818353 SCOPUS ID: 2-s2.0-16344395754 04/09/2005 99 Citations

Complex aortic valve repair as a durable and effective alternative to valve replacement in children with aortic valve disease. (Tweddell JS, Pelech AN, Frommelt PC, Jaquiss RD, Hoffman GM, Mussatto KA, Litwin SB) J Thorac Cardiovasc Surg 2005 Mar;129(3):551-8 PMID: 15746738 SCOPUS ID: 2-s2.0-14644444528 03/05/2005 53 Citations

Droperidol for perioperative sedation causes a transient prolongation of the QTc time in children under volatile anesthesia. (Stuth EA, Stucke AG, Cava JR, Hoffman GM, Berens RJ) Paediatr Anaesth 2004 Oct;14(10):831-7 PMID: 15385011 SCOPUS ID: 2-s2.0-4944220495 09/24/2004 16 Citations

Early cavopulmonary anastomosis in very young infants after the Norwood procedure: impact on oxygenation, resource utilization, and mortality. (Jaquiss RD, Ghanayem NS, Hoffman GM, Fedderly RT, Cava JR, Mussatto KA, Tweddell JS) J Thorac Cardiovasc Surg 2004 Apr;127(4):982-9 PMID: 15052194 SCOPUS ID: 2-s2.0-1842506295 03/31/2004 78 Citations

Alteration of the critical arteriovenous oxygen saturation relationship by sustained afterload reduction after the Norwood procedure. (Hoffman GM, Tweddell JS, Ghanayem NS, Mussatto KA, Stuth EA, Jaquis RD, Berger S) J Thorac Cardiovasc Surg 2004 Mar;127(3):738-45 PMID: 15001902 SCOPUS ID: 2-s2.0-1542314226 03/06/2004 113 Citations

Clinical evaluation of the effects of signal integrity and saturation on data availability and accuracy of Masimo SE and Nellcor N-395 oximeters in children. (Robertson FA, Hoffman GM) Anesth Analg 2004 Mar;98(3):617-22, table of contents PMID: 14980908 SCOPUS ID: 2-s2.0-1342309847 02/26/2004 19 Citations

Changes in cerebral and somatic oxygenation during stage 1 palliation of hypoplastic left heart syndrome using continuous regional cerebral perfusion. (Hoffman GM, Stuth EA, Jaquiss RD, Vanderwal PL, Staudt SR, Troshynski TJ, Ghanayem NS, Tweddell JS) J Thorac Cardiovasc Surg 2004 Jan;127(1):223-33 PMID: 14752434 SCOPUS ID: 2-s2.0-10744227442 01/31/2004 195 Citations

Home surveillance program prevents interstage mortality after the Norwood procedure. (Ghanayem NS, Hoffman GM, Mussatto KA, Cava JR, Frommelt PC, Rudd NA, Steltzer MM, Bevandic SM, Frisbee SS, Jaquiss RD, Litwin SB, Tweddell JS) J Thorac Cardiovasc Surg 2003 Nov;126(5):1367-77 PMID: 14666008 SCOPUS ID: 2-s2.0-10744232526 12/11/2003 315 Citations

Acupuncture for postoperative nausea and vomiting prophylaxis: where's the point? (Cohn AI) Anesthesiology 2002 Oct;97(4):1038-9; author reply 1039 PMID: 12357192 SCOPUS ID: 2-s2.0-0036790232 10/03/2002 1 Citation

Improved survival of patients undergoing palliation of hypoplastic left heart syndrome: lessons learned from 115 consecutive patients. (Tweddell JS, Hoffman GM, Mussatto KA, Fedderly RT, Berger S, Jaquiss RD, Ghanayem NS, Frisbee SJ, Litwin SB) Circulation 2002 Sep 24;106(12 Suppl 1):I82-9 PMID: 12354714 SCOPUS ID: 2-s2.0-0037167689 10/02/2002 500 Citations

Postoperative management in patients with complex congenital heart disease. (Tweddell JS, Hoffman GM) Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2002;5:187-205 PMID: 11994879 SCOPUS ID: 2-s2.0-0742296534 05/08/2002 61 Citations

Risk reduction in pediatric procedural sedation by application of an American Academy of Pediatrics/American Society of Anesthesiologists process model. (Hoffman GM, Nowakowski R, Troshynski TJ, Berens RJ, Weisman SJ) Pediatrics 2002 Feb;109(2):236-43 PMID: 11826201 SCOPUS ID: 2-s2.0-0036164093 02/05/2002 277 Citations

Electroacupuncture prophylaxis of postoperative nausea and vomiting following pediatric tonsillectomy with or without adenoidectomy. (Rusy LM, Hoffman GM, Weisman SJ) Anesthesiology 2002 Feb;96(2):300-5 PMID: 11818760 SCOPUS ID: 2-s2.0-0036164284 01/31/2002 115 Citations

L-arginine infusion lowers blood pressure in children. (Nelin LD, Hoffman GM) J Pediatr 2001 Nov;139(5):747-9 PMID: 11713459 SCOPUS ID: 2-s2.0-0035196654 11/20/2001 7 Citations

Venous saturation and the anaerobic threshold in neonates after the Norwood procedure for hypoplastic left heart syndrome. (Hoffman GM, Ghanayem NS, Kampine JM, Berger S, Mussatto KA, Litwin SB, Tweddell JS) Ann Thorac Surg 2000 Nov;70(5):1515-20; discussion 1521 PMID: 11093480 SCOPUS ID: 2-s2.0-0033766692 11/28/2000 151 Citations

Patients at risk for low systemic oxygen delivery after the Norwood procedure. (Tweddell JS, Hoffman GM, Fedderly RT, Ghanayem NS, Kampine JM, Berger S, Mussatto KA, Litwin SB) Ann Thorac Surg 2000 Jun;69(6):1893-9 PMID: 10892943 SCOPUS ID: 2-s2.0-0033947377 07/13/2000 93 Citations

Dilated nonreactive pupils secondary to neuromuscular blockade. (Schmidt JE, Tamburro RF, Hoffman GM) Anesthesiology 2000 May;92(5):1476-80 PMID: 10781295 SCOPUS ID: 2-s2.0-0034055774 04/26/2000 13 Citations

Pulmonary vascular responses during acute and sustained respiratory alkalosis or acidosis in intact newborn piglets. (Gordon JB, Rehorst-Paea LA, Hoffman GM, Nelin LD) Pediatr Res 1999 Dec;46(6):735-41 PMID: 10590032 SCOPUS ID: 2-s2.0-0032731295 12/10/1999 27 Citations

Unmeasured anions identified by the Fencl-Stewart method predict mortality better than base excess, anion gap, and lactate in patients in the pediatric intensive care unit. (Balasubramanyan N, Havens PL, Hoffman GM) Crit Care Med 1999 Aug;27(8):1577-81 PMID: 10470767 SCOPUS ID: 2-s2.0-0032855346 09/02/1999 216 Citations

Phenoxybenzamine improves systemic oxygen delivery after the Norwood procedure. (Tweddell JS, Hoffman GM, Fedderly RT, Berger S, Thomas JP Jr, Ghanayem NS, Kessel MW, Litwin SB) Ann Thorac Surg 1999 Jan;67(1):161-7; discussion 167-8 PMID: 10086542 SCOPUS ID: 2-s2.0-0032992421 03/23/1999 192 Citations

The use of inhaled nitric oxide in a wide variety of clinical problems. (Nelin LD, Hoffman GM) Pediatr Clin North Am 1998 Jun;45(3):531-48 PMID: 9653435 SCOPUS ID: 2-s2.0-0031866978 07/08/1998 36 Citations

Inhaled nitric oxide reduces the utilization of extracorporeal membrane oxygenation in persistent pulmonary hypertension of the newborn. (Hoffman GM, Ross GA, Day SE, Rice TB, Nelin LD) Crit Care Med 1997 Feb;25(2):352-9 PMID: 9034276 SCOPUS ID: 2-s2.0-0031037642 02/01/1997 68 Citations

Epidural analgesia improves outcome following pediatric fundoplication. A retrospective analysis. (McNeely JK, Farber NE, Rusy LM, Hoffman GM) Reg Anesth 1997;22(1):16-23 PMID: 9010942 SCOPUS ID: 2-s2.0-0031037734 01/01/1997 84 Citations

Airway complications of instrumentation: A physiologic approach (Hoffman GM) Respiratory Care 1995;40(1):97-107 SCOPUS ID: 2-s2.0-0028890889 01/01/1995 2 Citations

Relief of Pain and Anxiety in the PICU: Neither Too Much Too Soon Nor Too Little Too Late (Hoffman GM) Journal of Intensive Care Medicine November 1995;10(6):267-269 SCOPUS ID: 2-s2.0-0028845397 01/01/1995

Validation of a volumeless breath-by-breath method for measurement of respiratory quotient. (Hoffman GM, Torres A, Forster HV) J Appl Physiol (1985) 1993 Oct;75(4):1903-10 PMID: 8282649 SCOPUS ID: 2-s2.0-0027493854 10/01/1993 11 Citations

Ventilatory response to carbon dioxide in term infants after halothane and nitrous oxide anesthesia. (Palmisano BW, Setlock MA, Doyle MK, Rosner DR, Hoffman GM, Eckert JE) Anesth Analg 1993 Jun;76(6):1234-7 PMID: 8498659 SCOPUS ID: 2-s2.0-0027284850 06/01/1993 3 Citations

Diagnostic value of anemia, red blood cell morphology, and reticulocyte count for sickle cell disease. (Losek JD, Hellmich TR, Hoffman GM) Ann Emerg Med 1992 Aug;21(8):915-8 PMID: 1497156 SCOPUS ID: 2-s2.0-0026769252 08/01/1992 9 Citations

Postoperative pain relief in children from the parascalene injection technique. (McNeely JK, Hoffman GM, Eckert JE) Reg Anesth 1991;16(1):20-2 PMID: 2007100 SCOPUS ID: 2-s2.0-0025982020 01/01/1991 13 Citations

The homogeneous nature of the hemolytic uremic syndrome. (Havens PL, Hoffman GM, Shith KJ) Clin Pediatr (Phila) 1989 Oct;28(10):482-3 PMID: 2791440 SCOPUS ID: 2-s2.0-0024747598 10/01/1989 6 Citations

Corticosteroids as adjunctive therapy in bacterial meningitis. A meta-analysis of clinical trials. (Havens PL, Wendelberger KJ, Hoffman GM, Lee MB, Chusid MJ) Am J Dis Child 1989 Sep;143(9):1051-5 PMID: 2773883 SCOPUS ID: 2-s2.0-0024420539 09/01/1989 53 Citations

Dexamethasone therapy for bacterial meningitis. N Engl J Med 1989 Feb 16;320(7):463-5 PMID: 2913514 SCOPUS ID: 2-s2.0-0024556239 02/16/1989 6 Citations

Survival after chloroquine ingestion in a child. (Havens PL, Splaingard ML, Bousounis D, Hoffman GM) J Toxicol Clin Toxicol 1988;26(5-6):381-8 PMID: 2848136 SCOPUS ID: 2-s2.0-0024253746 01/01/1988 9 Citations

Effect of thyroid hormones on human mononuclear leukocyte lysosomal acid lipase activity. (Coates PM, Hoffman GM, Finegold DN) J Clin Endocrinol Metab 1982 Mar;54(3):559-62 PMID: 7056842 SCOPUS ID: 2-s2.0-0020412579 03/01/1982 9 Citations

Acid lipase activity of human lymphocytes. (Coates PM, Cortner JA, Hoffman GM, Brown SA) Biochim Biophys Acta 1979 Feb 26;572(2):225-34 PMID: 427176 SCOPUS ID: 2-s2.0-0018741951 02/26/1979 31 Citations

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Profiles for MCW, MU, MSOE, UWM, BCW, CW, Froedtert, and VA Faculty

George M. Hoffman MD

Chief, Professor

Publications (129)