Medical College of Wisconsin
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Michael W. Lawlor MD, PhD

Michael W. Lawlor MD, PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Pathology
Division: Administration
Program: Pediatrics

Member of the Neuroscience Research Center


  • Novel autosomal dominant TNNT1 mutation causing nemaline myopathy. (Konersman CG, Freyermuth F, Winder TL, Lawlor MW, Lagier-Tourenne C, Patel SB) Mol Genet Genomic Med 2017 Nov;5(6):678-691 PMID: 29178646 PMCID: PMC5702563 11/28/2017
  • Diaphragm Atrophy and Weakness in the Absence of Mitochondrial Dysfunction in the Critically Ill. (van den Berg M, Hooijman PE, Beishuizen A, de Waard MC, Paul MA, Hartemink KJ, van Hees HWH, Lawlor MW, Brocca L, Bottinelli R, Pellegrino MA, Stienen GJM, Heunks LMA, Wüst RCI, Ottenheijm CAC) Am J Respir Crit Care Med 2017 Dec 15;196(12):1544-1558 PMID: 28787181 PMCID: PMC5754442 08/09/2017
  • Host interleukin 6 production regulates inflammation but not tryptophan metabolism in the brain during murine GVHD. (Belle L, Zhou V, Stuhr KL, Beatka M, Siebers EM, Knight JM, Lawlor MW, Weaver C, Hashizume M, Hillard CJ, Drobyski WR) JCI Insight 2017 Jul 20;2(14) PMID: 28724796 PMCID: PMC5518565 07/21/2017
  • Long-term effects of systemic gene therapy in a canine model of myotubular myopathy. (Elverman M, Goddard MA, Mack D, Snyder JM, Lawlor MW, Meng H, Beggs AH, Buj-Bello A, Poulard K, Marsh AP, Grange RW, Kelly VE, Childers MK) Muscle Nerve 2017 Nov;56(5):943-953 PMID: 28370029 PMCID: PMC5620115 04/04/2017
  • Systemic AAV8-Mediated Gene Therapy Drives Whole-Body Correction of Myotubular Myopathy in Dogs. (Mack DL, Poulard K, Goddard MA, Latournerie V, Snyder JM, Grange RW, Elverman MR, Denard J, Veron P, Buscara L, Le Bec C, Hogrel JY, Brezovec AG, Meng H, Yang L, Liu F, O'Callaghan M, Gopal N, Kelly VE, Smith BK, Strande JL, Mavilio F, Beggs AH, Mingozzi F, Lawlor MW, Buj-Bello A, Childers MK) Mol Ther 2017 Apr 05;25(4):839-854 PMID: 28237839 PMCID: PMC5383631 02/27/2017
  • Macrocyclic MEK1/2 inhibitor with efficacy in a mouse model of cardiomyopathy caused by lamin A/C gene mutation. (Wu W, Chordia MD, Hart BP, Kumarasinghe ES, Ji MK, Bhargava A, Lawlor MW, Shin JY, Sera F, Homma S, Muchir A, Khire UR, Worman HJ) Bioorg Med Chem 2017 02 01;25(3):1004-1013 PMID: 28011205 PMCID: PMC5291759 12/25/2016
  • Phosphatidylinositol 3-kinase inhibition restores Ca2+ release defects and prolongs survival in myotubularin-deficient mice. (Kutchukian C, Lo Scrudato M, Tourneur Y, Poulard K, Vignaud A, Berthier C, Allard B, Lawlor MW, Buj-Bello A, Jacquemond V) Proc Natl Acad Sci U S A 2016 Dec 13;113(50):14432-14437 PMID: 27911767 PMCID: PMC5167204 12/03/2016
  • Presentation and Diagnostic Evaluation of Mitochondrial Disease. (Dimmock DP, Lawlor MW) Pediatr Clin North Am 2017 Feb;64(1):161-171 PMID: 27894442 PMCID: PMC5130109 11/30/2016
  • CD82 Is a Marker for Prospective Isolation of Human Muscle Satellite Cells and Is Linked to Muscular Dystrophies. (Alexander MS, Rozkalne A, Colletta A, Spinazzola JM, Johnson S, Rahimov F, Meng H, Lawlor MW, Estrella E, Kunkel LM, Gussoni E) Cell Stem Cell 2016 Dec 01;19(6):800-807 PMID: 27641304 PMCID: PMC5135584 09/20/2016
  • In Reply. (Lawlor MW) Arch Pathol Lab Med 2016 09;140(9):879 PMID: 27575262 08/31/2016
  • Treatment with ActRIIB-mFc Produces Myofiber Growth and Improves Lifespan in the Acta1 H40Y Murine Model of Nemaline Myopathy. (Tinklenberg J, Meng H, Yang L, Liu F, Hoffmann RG, Dasgupta M, Allen KP, Beggs AH, Hardeman EC, Pearsall RS, Fitts RH, Lawlor MW) Am J Pathol 2016 Jun;186(6):1568-81 PMID: 27102768 PMCID: PMC4901141 04/23/2016
  • Mechanosensory and ATP Release Deficits following Keratin14-Cre-Mediated TRPA1 Deletion Despite Absence of TRPA1 in Murine Keratinocytes. (Zappia KJ, Garrison SR, Palygin O, Weyer AD, Barabas ME, Lawlor MW, Staruschenko A, Stucky CL) PLoS One 2016;11(3):e0151602 PMID: 26978657 PMCID: PMC4792390 03/16/2016
  • Skeletal Muscle Pathology in X-Linked Myotubular Myopathy: Review With Cross-Species Comparisons. (Lawlor MW, Beggs AH, Buj-Bello A, Childers MK, Dowling JJ, James ES, Meng H, Moore SA, Prasad S, Schoser B, Sewry CA) J Neuropathol Exp Neurol 2016 Feb;75(2):102-10 PMID: 26823526 PMCID: PMC4765322 01/30/2016
  • Potentially diagnostic electron paramagnetic resonance spectra elucidate the underlying mechanism of mitochondrial dysfunction in the deoxyguanosine kinase deficient rat model of a genetic mitochondrial DNA depletion syndrome. (Bennett B, Helbling D, Meng H, Jarzembowski J, Geurts AM, Friederich MW, Van Hove JL, Lawlor MW, Dimmock DP) Free Radic Biol Med 2016 Mar;92:141-51 PMID: 26773591 PMCID: PMC5047058 01/17/2016
  • Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy. (Goddard MA, Mack DL, Czerniecki SM, Kelly VE, Snyder JM, Grange RW, Lawlor MW, Smith BK, Beggs AH, Childers MK) Ann Transl Med 2015 Oct;3(18):262 PMID: 26605308 PMCID: PMC4630545 11/26/2015
  • Common Data Elements for Muscle Biopsy Reporting. (Dastgir J, Rutkowski A, Alvarez R, Cossette SA, Yan K, Hoffmann RG, Sewry C, Hayashi YK, Goebel HH, Bonnemann C, Lawlor MW) Arch Pathol Lab Med 2016 Jan;140(1):51-65 PMID: 26132600 PMCID: PMC4975562 07/02/2015
  • Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type-dependent changes in trophicity: novel insights in nemaline myopathy. (Li F, Buck D, De Winter J, Kolb J, Meng H, Birch C, Slater R, Escobar YN, Smith JE 3rd, Yang L, Konhilas J, Lawlor MW, Ottenheijm C, Granzier HL) Hum Mol Genet 2015 Sep 15;24(18):5219-33 PMID: 26123491 PMCID: PMC4550825 07/01/2015
  • Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients. (Hooijman PE, Beishuizen A, Witt CC, de Waard MC, Girbes AR, Spoelstra-de Man AM, Niessen HW, Manders E, van Hees HW, van den Brom CE, Silderhuis V, Lawlor MW, Labeit S, Stienen GJ, Hartemink KJ, Paul MA, Heunks LM, Ottenheijm CA) Am J Respir Crit Care Med 2015 May 15;191(10):1126-38 PMID: 25760684 PMCID: PMC4451621 03/12/2015
  • BAG3 myofibrillar myopathy presenting with cardiomyopathy. (Konersman CG, Bordini BJ, Scharer G, Lawlor MW, Zangwill S, Southern JF, Amos L, Geddes GC, Kliegman R, Collins MP) Neuromuscul Disord 2015 May;25(5):418-22 PMID: 25728519 03/03/2015
  • Isolation and immortalization of patient-derived cell lines from muscle biopsy for disease modeling. (Robin JD, Wright WE, Zou Y, Cossette SC, Lawlor MW, Gussoni E) J Vis Exp 2015 Jan 18(95):52307 PMID: 25651101 PMCID: PMC4354544 02/05/2015
  • Whole-thorax irradiation induces hypoxic respiratory failure, pleural effusions and cardiac remodeling. (Medhora M, Gao F, Glisch C, Narayanan J, Sharma A, Harmann LM, Lawlor MW, Snyder LA, Fish BL, Down JD, Moulder JE, Strande JL, Jacobs ER) J Radiat Res 2015 Mar;56(2):248-60 PMID: 25368342 PMCID: PMC4380043 11/05/2014
  • Triadopathies: an emerging class of skeletal muscle diseases. (Dowling JJ, Lawlor MW, Dirksen RT) Neurotherapeutics 2014 Oct;11(4):773-85 PMID: 25168790 PMCID: PMC4391390 08/30/2014
  • Tissue triage and freezing for models of skeletal muscle disease. (Meng H, Janssen PM, Grange RW, Yang L, Beggs AH, Swanson LC, Cossette SA, Frase A, Childers MK, Granzier H, Gussoni E, Lawlor MW) J Vis Exp 2014 Jul 15(89) PMID: 25078247 PMCID: PMC4215994 08/01/2014
  • Differential muscle hypertrophy is associated with satellite cell numbers and Akt pathway activation following activin type IIB receptor inhibition in Mtm1 p.R69C mice. (Lawlor MW, Viola MG, Meng H, Edelstein RV, Liu F, Yan K, Luna EJ, Lerch-Gaggl A, Hoffmann RG, Pierson CR, Buj-Bello A, Lachey JL, Pearsall S, Yang L, Hillard CJ, Beggs AH) Am J Pathol 2014 Jun;184(6):1831-42 PMID: 24726641 PMCID: PMC4044712 04/15/2014
  • Gene therapy prolongs survival and restores function in murine and canine models of myotubular myopathy. (Childers MK, Joubert R, Poulard K, Moal C, Grange RW, Doering JA, Lawlor MW, Rider BE, Jamet T, Danièle N, Martin S, Rivière C, Soker T, Hammer C, Van Wittenberghe L, Lockard M, Guan X, Goddard M, Mitchell E, Barber J, Williams JK, Mack DL, Furth ME, Vignaud A, Masurier C, Mavilio F, Moullier P, Beggs AH, Buj-Bello A) Sci Transl Med 2014 Jan 22;6(220):220ra10 PMID: 24452262 PMCID: PMC4105197 01/24/2014
  • Dystrophin-deficient cardiomyocytes derived from human urine: new biologic reagents for drug discovery. (Guan X, Mack DL, Moreno CM, Strande JL, Mathieu J, Shi Y, Markert CD, Wang Z, Liu G, Lawlor MW, Moorefield EC, Jones TN, Fugate JA, Furth ME, Murry CE, Ruohola-Baker H, Zhang Y, Santana LF, Childers MK) Stem Cell Res 2014 Mar;12(2):467-80 PMID: 24434629 PMCID: PMC3966181 01/18/2014
  • G-protein coupled receptor 56 promotes myoblast fusion through serum response factor- and nuclear factor of activated T-cell-mediated signalling but is not essential for muscle development in vivo. (Wu MP, Doyle JR, Barry B, Beauvais A, Rozkalne A, Piao X, Lawlor MW, Kopin AS, Walsh CA, Gussoni E) FEBS J 2013 Dec;280(23):6097-113 PMID: 24102982 PMCID: PMC3877849 10/10/2013
  • Recessive truncating titin gene, TTN, mutations presenting as centronuclear myopathy. (Ceyhan-Birsoy O, Agrawal PB, Hidalgo C, Schmitz-Abe K, DeChene ET, Swanson LC, Soemedi R, Vasli N, Iannaccone ST, Shieh PB, Shur N, Dennison JM, Lawlor MW, Laporte J, Markianos K, Fairbrother WG, Granzier H, Beggs AH) Neurology 2013 Oct 01;81(14):1205-14 PMID: 23975875 PMCID: PMC3795603 08/27/2013
  • Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy. (Ottenheijm CA, Buck D, de Winter JM, Ferrara C, Piroddi N, Tesi C, Jasper JR, Malik FI, Meng H, Stienen GJ, Beggs AH, Labeit S, Poggesi C, Lawlor MW, Granzier H) Brain 2013 Jun;136(Pt 6):1718-31 PMID: 23715096 PMCID: PMC3673460 05/30/2013
  • Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutations. (de Winter JM, Buck D, Hidalgo C, Jasper JR, Malik FI, Clarke NF, Stienen GJ, Lawlor MW, Beggs AH, Ottenheijm CA, Granzier H) J Med Genet 2013 Jun;50(6):383-92 PMID: 23572184 PMCID: PMC3865762 04/11/2013
  • Selenoprotein N deficiency in mice is associated with abnormal lung development. (Moghadaszadeh B, Rider BE, Lawlor MW, Childers MK, Grange RW, Gupta K, Boukedes SS, Owen CA, Beggs AH) FASEB J 2013 Apr;27(4):1585-99 PMID: 23325319 PMCID: PMC3606527 01/18/2013
  • Enzyme replacement therapy rescues weakness and improves muscle pathology in mice with X-linked myotubular myopathy. (Lawlor MW, Armstrong D, Viola MG, Widrick JJ, Meng H, Grange RW, Childers MK, Hsu CP, O'Callaghan M, Pierson CR, Buj-Bello A, Beggs AH) Hum Mol Genet 2013 Apr 15;22(8):1525-38 PMID: 23307925 PMCID: PMC3605830 01/12/2013
  • Large duplication in MTM1 associated with myotubular myopathy. (Amburgey K, Lawlor MW, Del Gaudio D, Cheng YW, Fitzpatrick C, Minor A, Li X, Aughton D, Das S, Beggs AH, Dowling JJ) Neuromuscul Disord 2013 Mar;23(3):214-8 PMID: 23273872 PMCID: PMC3594803 01/01/2013
  • Myotubularin-deficient myoblasts display increased apoptosis, delayed proliferation, and poor cell engraftment. (Lawlor MW, Alexander MS, Viola MG, Meng H, Joubert R, Gupta V, Motohashi N, Manfready RA, Hsu CP, Huang P, Buj-Bello A, Kunkel LM, Beggs AH, Gussoni E) Am J Pathol 2012 Sep;181(3):961-8 PMID: 22841819 PMCID: PMC3432426 07/31/2012
  • Oxygen gas-filled microparticles provide intravenous oxygen delivery. (Kheir JN, Scharp LA, Borden MA, Swanson EJ, Loxley A, Reese JH, Black KJ, Velazquez LA, Thomson LM, Walsh BK, Mullen KE, Graham DA, Lawlor MW, Brugnara C, Bell DC, McGowan FX Jr) Sci Transl Med 2012 Jun 27;4(140):140ra88 PMID: 22745438 06/30/2012
  • Thermoresponsive nanogels for prolonged duration local anesthesia. (Hoare T, Young S, Lawlor MW, Kohane DS) Acta Biomater 2012 Oct;8(10):3596-605 PMID: 22732383 PMCID: PMC3429626 06/27/2012
  • Toxicogenomic analysis of a sustained release local anesthetic delivery system. (Shichor I, Shomron N, Lawlor MW, Bae SA, Zoldan J, Langer R, Kohane DS) Biomaterials 2012 May;33(13):3586-93 PMID: 22341215 PMCID: PMC3288387 02/22/2012
  • Nanogel scavengers for drugs: local anesthetic uptake by thermoresponsive nanogels. (Hoare T, Sivakumaran D, Stefanescu CF, Lawlor MW, Kohane DS) Acta Biomater 2012 Apr;8(4):1450-8 PMID: 22244983 PMCID: PMC3289739 01/17/2012
  • Modeling the human MTM1 p.R69C mutation in murine Mtm1 results in exon 4 skipping and a less severe myotubular myopathy phenotype. (Pierson CR, Dulin-Smith AN, Durban AN, Marshall ML, Marshall JT, Snyder AD, Naiyer N, Gladman JT, Chandler DS, Lawlor MW, Buj-Bello A, Dowling JJ, Beggs AH) Hum Mol Genet 2012 Feb 15;21(4):811-25 PMID: 22068590 PMCID: PMC3263994 11/10/2011
  • An in vivo rodent model of contraction-induced injury in the quadriceps muscle. (Pratt SJ, Lawlor MW, Shah SB, Lovering RM) Injury 2012 Jun;43(6):788-93 PMID: 22001505 PMCID: PMC3310278 10/18/2011
  • Novel mutations in NEB cause abnormal nebulin expression and markedly impaired muscle force generation in severe nemaline myopathy. (Lawlor MW, Ottenheijm CA, Lehtokari VL, Cho K, Pelin K, Wallgren-Pettersson C, Granzier H, Beggs AH) Skelet Muscle 2011 Jun 20;1(1):23 PMID: 21798101 PMCID: PMC3156646 07/30/2011
  • Elasticity and safety of alkoxyethyl cyanoacrylate tissue adhesives. (Mizrahi B, Stefanescu CF, Yang C, Lawlor MW, Ko D, Langer R, Kohane DS) Acta Biomater 2011 Aug;7(8):3150-7 PMID: 21569875 PMCID: PMC4059060 05/17/2011
  • Changes in cross-bridge cycling underlie muscle weakness in patients with tropomyosin 3-based myopathy. (Ottenheijm CA, Lawlor MW, Stienen GJ, Granzier H, Beggs AH) Hum Mol Genet 2011 May 15;20(10):2015-25 PMID: 21357678 PMCID: PMC3080611 03/02/2011
  • Inhibition of activin receptor type IIB increases strength and lifespan in myotubularin-deficient mice. (Lawlor MW, Read BP, Edelstein R, Yang N, Pierson CR, Stein MJ, Wermer-Colan A, Buj-Bello A, Lachey JL, Seehra JS, Beggs AH) Am J Pathol 2011 Feb;178(2):784-93 PMID: 21281811 PMCID: PMC3069865 02/02/2011
  • Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 gene. (Zhou Y, Cheunsuchon P, Nakayama Y, Lawlor MW, Zhong Y, Rice KA, Zhang L, Zhang X, Gordon FE, Lidov HG, Bronson RT, Klibanski A) Development 2010 Aug;137(16):2643-52 PMID: 20610486 PMCID: PMC2910384 07/09/2010
  • Functional muscle analysis of the Tcap knockout mouse. (Markert CD, Meaney MP, Voelker KA, Grange RW, Dalley HW, Cann JK, Ahmed M, Bishwokarma B, Walker SJ, Yu SX, Brown M, Lawlor MW, Beggs AH, Childers MK) Hum Mol Genet 2010 Jun 01;19(11):2268-83 PMID: 20233748 PMCID: PMC2865379 03/18/2010
  • Neuropathology of a fatal case of posterior reversible encephalopathy syndrome. (Kheir JN, Lawlor MW, Ahn ES, Lehmann L, Riviello JJ, Silvera VM, McManus M, Folkerth RD) Pediatr Dev Pathol 2010 Sep-Oct;13(5):397-403 PMID: 20158377 02/18/2010
  • Mutations of tropomyosin 3 (TPM3) are common and associated with type 1 myofiber hypotrophy in congenital fiber type disproportion. (Lawlor MW, Dechene ET, Roumm E, Geggel AS, Moghadaszadeh B, Beggs AH) Hum Mutat 2010 Feb;31(2):176-83 PMID: 19953533 PMCID: PMC2815199 12/03/2009
  • Prolonged duration local anesthesia with minimal toxicity. (Epstein-Barash H, Shichor I, Kwon AH, Hall S, Lawlor MW, Langer R, Kohane DS) Proc Natl Acad Sci U S A 2009 Apr 28;106(17):7125-30 PMID: 19365067 PMCID: PMC2678453 04/15/2009
  • Effect of chemical permeation enhancers on nerve blockade. (Simons EJ, Bellas E, Lawlor MW, Kohane DS) Mol Pharm 2009 Jan-Feb;6(1):265-73 PMID: 19105721 PMCID: PMC2646764 12/25/2008
  • Three-dimensional conductive constructs for nerve regeneration. (George PM, Saigal R, Lawlor MW, Moore MJ, LaVan DA, Marini RP, Selig M, Makhni M, Burdick JA, Langer R, Kohane DS) J Biomed Mater Res A 2009 Nov;91(2):519-27 PMID: 18985787 11/06/2008
  • Malignant solitary fibrous tumour of the meninges with marked amianthoid fibre deposition. (Lawlor MW, Nielsen GP, Louis DN) Neuropathol Appl Neurobiol 2008 Oct;34(5):569-72 PMID: 18298634 02/27/2008
  • Anti-neurofilament antibodies in neuropathy with monoclonal gammopathy of undetermined significance produce experimental motor nerve conduction block. (Stubbs EB Jr, Lawlor MW, Richards MP, Siddiqui K, Fisher MA, Bhoopalam N, Siegel GJ) Acta Neuropathol 2003 Feb;105(2):109-16 PMID: 12536221 01/22/2003
  • Antibodies to L-periaxin in sera of patients with peripheral neuropathy produce experimental sensory nerve conduction deficits. (Lawlor MW, Richards MP, De Vries GH, Fisher MA, Stubbs EB Jr) J Neurochem 2002 Nov;83(3):592-600 PMID: 12390521 10/23/2002
  • Sensory nerve conduction deficit in experimental monoclonal gammopathy of undetermined significance (MGUS) neuropathy. (Lawlor MW, Richards MP, Fisher MA, Stubbs EB Jr) Muscle Nerve 2001 Jun;24(6):809-16 PMID: 11360265 05/22/2001
  • Assessment of serum-mediated neurotoxicity in Navajo neuropathy. (Lawlor MW, Holve S, Stubbs EB Jr) Electromyogr Clin Neurophysiol 2000 Jun;40(4):211-4 PMID: 10907598 07/25/2000
  • Last update: 01/02/2018
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