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Sridhar Rao MD, PhD

Sridhar Rao MD, PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Hematology and Oncology - Pediatrics
Program: Hematology

Member of the Cancer Center
Member of the Genomic Sciences and Precision Medicine Center (GSPMC)

Publications (48)

  • Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome. (Yang C, Siebert JR, Burns R, Gerbec ZJ, Bonacci B, Rymaszewski A, Rau M, Riese MJ, Rao S, Carlson KS, Routes JM, Verbsky JW, Thakar MS, Malarkannan S) Nat Commun 2019 Sep 02;10(1):3931 PMID: 31477722 PMCID: PMC6718415 SCOPUS ID: 2-s2.0-85071610251 09/04/2019    
  • Deletion of Tet proteins results in quantitative disparities during ESC differentiation partially attributable to alterations in gene expression. (Reimer M Jr, Pulakanti K, Shi L, Abel A, Liang M, Malarkannan S, Rao S) BMC Dev Biol 2019 07 08;19(1):16 PMID: 31286885 PMCID: PMC6615237 SCOPUS ID: 2-s2.0-85068878011 07/10/2019    
  • Critical role of Jumonji domain of JMJD1C in MLL-rearranged leukemia. (Izaguirre-Carbonell J, Christiansen L, Burns R, Schmitz J, Li C, Mokry RL, Bluemn T, Zheng Y, Shen J, Carlson KS, Rao S, Wang D, Zhu N) Blood Adv 2019 May 14;3(9):1499-1511 PMID: 31076406 PMCID: PMC6517669 SCOPUS ID: 2-s2.0-85068626845 05/12/2019       1 Citation
  • Stem cell damage after chemotherapy- can we do better? (Tang J, Zhu N, Rao S, Carlson KS) Best Pract Res Clin Haematol 2019 03;32(1):31-39 PMID: 30927973 04/01/2019    
  • Mature IgD B cells maintain tolerance by promoting regulatory T cell homeostasis. (Ray A, Khalil MI, Pulakanti KL, Burns RT, Gurski CJ, Basu S, Wang D, Rao S, Dittel BN) Nat Commun 2019 01 14;10(1):190 PMID: 30643147 PMCID: PMC6331566 SCOPUS ID: 2-s2.0-85060004031 01/16/2019    
  • HNF4A Regulates the Formation of Hepatic Progenitor Cells from Human iPSC-Derived Endoderm by Facilitating Efficient Recruitment of RNA Pol II. (DeLaForest A, Di Furio F, Jing R, Ludwig-Kubinski A, Twaroski K, Urick A, Pulakanti K, Rao S, Duncan SA) Genes (Basel) 2018 Dec 28;10(1) PMID: 30597922 PMCID: PMC6356828 01/02/2019    
  • Genome-Wide Maps of Transcription Regulatory Elements and Transcription Enhancers in Development and Disease. (Agrawal P, Heimbruch KE, Rao S) Compr Physiol 2018 12 13;9(1):439-455 PMID: 30549021 PMCID: PMC6566905 SCOPUS ID: 2-s2.0-85058739003 12/15/2018    
  • Degenerate minigene library analysis enables identification of altered branch point utilization by mutant splicing factor 3B1 (SF3B1). (Gupta AK, Murthy T, Paul KV, Ramirez O, Fisher JB, Rao S, Rosenberg AB, Seelig G, Minella AC, Pillai MM) Nucleic Acids Res 2019 01 25;47(2):970-980 PMID: 30462273 PMCID: PMC6344872 11/22/2018    
  • A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis. (Volk A, Liang K, Suraneni P, Li X, Zhao J, Bulic M, Marshall S, Pulakanti K, Malinge S, Taub J, Ge Y, Rao S, Bartom E, Shilatifard A, Crispino JD) Cancer Cell 2018 11 12;34(5):707-723.e7 PMID: 30423293 PMCID: PMC6235627 11/14/2018       3 Citations
  • Tumor suppressor Interferon Regulatory Factor 1 selectively blocks expression of endogenous retrovirus. (Stoltz KP, Jondle CN, Pulakanti K, Sylvester PA, Urrutia R, Rao S, Tarakanova VL) Virology 2019 01 02;526:52-60 PMID: 30342302 SCOPUS ID: 2-s2.0-85054799725 10/21/2018       1 Citation
  • Frontline Science: PECAM-1 (CD31) expression in naïve and memory, but not acutely activated, CD8 T cells. (Newman DK, Fu G, McOlash L, Schauder D, Newman PJ, Cui W, Rao S, Johnson BD, Gershan JA, Riese MJ) J Leukoc Biol 2018 11;104(5):883-893 PMID: 30063264 PMCID: PMC6195461 SCOPUS ID: 2-s2.0-85053248137 08/01/2018       3 Citations
  • Cyclin-dependent kinase 1 (CDK1) and CDK2 have opposing roles in regulating interactions of splicing factor 3B1 with chromatin. (Murthy T, Bluemn T, Gupta AK, Reimer M Jr, Rao S, Pillai MM, Minella AC) J Biol Chem 2018 06 29;293(26):10220-10234 PMID: 29764937 PMCID: PMC6028971 05/17/2018       1 Citation
  • Dextran Enhances the Lentiviral Transduction Efficiency of Murine and Human Primary NK Cells. (Nanbakhsh A, Best B, Riese M, Rao S, Wang L, Medin J, Thakar MS, Malarkannan S) J Vis Exp 2018 01 15(131) PMID: 29364266 PMCID: PMC5908645 SCOPUS ID: 2-s2.0-85041082468 01/25/2018    
  • Ruxolitinib for treatment of refractory hemophagocytic lymphohistiocytosis. (Broglie L, Pommert L, Rao S, Thakar M, Phelan R, Margolis D, Talano J) Blood Adv 2017 Aug 22;1(19):1533-1536 PMID: 29296794 PMCID: PMC5728466 01/04/2018    
  • Cohesin mutations: contributors to myeloid malignancies. (Meyer AE, Rao S, Fisher JB) Oncotarget 2017 Oct 06;8(46):80107-80108 PMID: 29113287 PMCID: PMC5655182 11/09/2017    
  • Nanog Expression in Embryonic Stem Cells - An Ideal Model System to Dissect Enhancer Function. (Blinka S, Rao S) Bioessays 2017 Dec;39(12) PMID: 28977693 PMCID: PMC5878941 10/05/2017       2 Citations
  • T Cells Deficient in Diacylglycerol Kinase ζ Are Resistant to PD-1 Inhibition and Help Create Persistent Host Immunity to Leukemia. (Jing W, Gershan JA, Holzhauer S, Weber J, Palen K, McOlash L, Pulakanti K, Wesley E, Rao S, Johnson BD, Riese MJ) Cancer Res 2017 10 15;77(20):5676-5686 PMID: 28916658 SCOPUS ID: 2-s2.0-85031429221 09/17/2017       3 Citations
  • Cohesin Mutations in Myeloid Malignancies. (Fisher JB, McNulty M, Burke MJ, Crispino JD, Rao S) Trends Cancer 2017 04;3(4):282-293 PMID: 28626802 PMCID: PMC5472227 06/20/2017       10 Citations
  • GATA6 is essential for endoderm formation from human pluripotent stem cells. (Fisher JB, Pulakanti K, Rao S, Duncan SA) Biol Open 2017 Jul 15;6(7):1084-1095 PMID: 28606935 PMCID: PMC5550920 06/14/2017    
  • GATA4 Is Sufficient to Establish Jejunal Versus Ileal Identity in the Small Intestine. (Thompson CA, Wojta K, Pulakanti K, Rao S, Dawson P, Battle MA) Cell Mol Gastroenterol Hepatol 2017 May;3(3):422-446 PMID: 28462382 PMCID: PMC5404030 05/04/2017    
  • E2F-2 Promotes Nuclear Condensation and Enucleation of Terminally Differentiated Erythroblasts. (Swartz KL, Wood SN, Murthy T, Ramirez O, Qin G, Pillai MM, Rao S, Minella AC) Mol Cell Biol 2017 01 01;37(1) PMID: 27795297 PMCID: PMC5192079 11/01/2016       5 Citations
  • Super-Enhancers at the Nanog Locus Differentially Regulate Neighboring Pluripotency-Associated Genes. (Blinka S, Reimer MH Jr, Pulakanti K, Rao S) Cell Rep 2016 09 27;17(1):19-28 PMID: 27681417 PMCID: PMC5111363 09/30/2016       26 Citations
  • Identification of Transcribed Enhancers by Genome-Wide Chromatin Immunoprecipitation Sequencing. (Blinka S, Reimer MH Jr, Pulakanti K, Pinello L, Yuan GC, Rao S) Methods Mol Biol 2017;1468:91-109 PMID: 27662872 PMCID: PMC5111358 09/25/2016       4 Citations
  • The cohesin subunit Rad21 is a negative regulator of hematopoietic self-renewal through epigenetic repression of Hoxa7 and Hoxa9. (Fisher JB, Peterson J, Reimer M, Stelloh C, Pulakanti K, Gerbec ZJ, Abel AM, Strouse JM, Strouse C, McNulty M, Malarkannan S, Crispino JD, Milanovich S, Rao S) Leukemia 2017 03;31(3):712-719 PMID: 27554164 PMCID: PMC5332284 SCOPUS ID: 2-s2.0-84989244308 08/25/2016       13 Citations
  • Signaling in Effector Lymphocytes: Insights toward Safer Immunotherapy. (Rajasekaran K, Riese MJ, Rao S, Wang L, Thakar MS, Sentman CL, Malarkannan S) Front Immunol 2016;7:176 PMID: 27242783 PMCID: PMC4863891 06/01/2016    
  • The cohesin-associated protein Wapal is required for proper Polycomb-mediated gene silencing. (Stelloh C, Reimer MH, Pulakanti K, Blinka S, Peterson J, Pinello L, Jia S, Roumiantsev S, Hessner MJ, Milanovich S, Yuan GC, Rao S) Epigenetics Chromatin 2016;9:14 PMID: 27087855 PMCID: PMC4832553 04/19/2016    
  • CRISPR/Cas9-mediated conversion of human platelet alloantigen allotypes. (Zhang N, Zhi H, Curtis BR, Rao S, Jobaliya C, Poncz M, French DL, Newman PJ) Blood 2016 Feb 11;127(6):675-80 PMID: 26634302 PMCID: PMC4751021 SCOPUS ID: 2-s2.0-84959330331 12/05/2015       17 Citations
  • IQGAP1: insights into the function of a molecular puppeteer. (Abel AM, Schuldt KM, Rajasekaran K, Hwang D, Riese MJ, Rao S, Thakar MS, Malarkannan S) Mol Immunol 2015 Jun;65(2):336-49 PMID: 25733387 PMCID: PMC4480615 SCOPUS ID: 2-s2.0-84923604300 03/04/2015       19 Citations
  • Dynamic switching of active promoter and enhancer domains regulates Tet1 and Tet2 expression during cell state transitions between pluripotency and differentiation. (Sohni A, Bartoccetti M, Khoueiry R, Spans L, Vande Velde J, De Troyer L, Pulakanti K, Claessens F, Rao S, Koh KP) Mol Cell Biol 2015 Mar;35(6):1026-42 PMID: 25582196 PMCID: PMC4333094 01/15/2015       23 Citations
  • Sall4 overexpression blocks murine hematopoiesis in a dose-dependent manner. (Milanovich S, Peterson J, Allred J, Stelloh C, Rajasekaran K, Fisher J, Duncan SA, Malarkannan S, Rao S) Exp Hematol 2015 Jan;43(1):53-64.e1-8 PMID: 25246269 PMCID: PMC4268405 SCOPUS ID: 2-s2.0-84961288383 09/24/2014       13 Citations
  • A human pluripotent stem cell surface N-glycoproteome resource reveals markers, extracellular epitopes, and drug targets. (Boheler KR, Bhattacharya S, Kropp EM, Chuppa S, Riordon DR, Bausch-Fluck D, Burridge PW, Wu JC, Wersto RP, Chan GC, Rao S, Wollscheid B, Gundry RL) Stem Cell Reports 2014 Jul 08;3(1):185-203 PMID: 25068131 PMCID: PMC4110789 07/30/2014       47 Citations
  • Enhancer transcribed RNAs arise from hypomethylated, Tet-occupied genomic regions. (Pulakanti K, Pinello L, Stelloh C, Blinka S, Allred J, Milanovich S, Kiblawi S, Peterson J, Wang A, Yuan GC, Rao S) Epigenetics 2013 Dec;8(12):1303-20 PMID: 24135681 PMCID: PMC3933491 10/19/2013       30 Citations
  • Embryonic Stem Cells: A Perfect Tool for Studying Mammalian Transcriptional Enhancers. (Rao S) J Stem Cell Res Ther 2012 Jul 05;Suppl 10 PMID: 24303336 PMCID: PMC3844140 07/05/2012    
  • A cell surfaceome map for immunophenotyping and sorting pluripotent stem cells. (Gundry RL, Riordon DR, Tarasova Y, Chuppa S, Bhattacharya S, Juhasz O, Wiedemeier O, Milanovich S, Noto FK, Tchernyshyov I, Raginski K, Bausch-Fluck D, Tae HJ, Marshall S, Duncan SA, Wollscheid B, Wersto RP, Rao S, Van Eyk JE, Boheler KR) Mol Cell Proteomics 2012 Aug;11(8):303-16 PMID: 22493178 PMCID: PMC3412963 04/12/2012       32 Citations
  • Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. (Koh KP, Yabuuchi A, Rao S, Huang Y, Cunniff K, Nardone J, Laiho A, Tahiliani M, Sommer CA, Mostoslavsky G, Lahesmaa R, Orkin SH, Rodig SJ, Daley GQ, Rao A) Cell Stem Cell 2011 Feb 04;8(2):200-13 PMID: 21295276 PMCID: PMC3134318 02/08/2011       487 Citations
  • Differential roles of Sall4 isoforms in embryonic stem cell pluripotency. (Rao S, Zhen S, Roumiantsev S, McDonald LT, Yuan GC, Orkin SH) Mol Cell Biol 2010 Nov;30(22):5364-80 PMID: 20837710 PMCID: PMC2976381 09/15/2010       100 Citations
  • A protein interaction network for pluripotency of embryonic stem cells. (Wang J, Rao S, Chu J, Shen X, Levasseur DN, Theunissen TW, Orkin SH) Nature 2006 Nov 16;444(7117):364-8 PMID: 17093407 11/10/2006       792 Citations
  • Unraveling the transcriptional network controlling ES cell pluripotency. (Rao S, Orkin SH) Genome Biol 2006;7(8):230 PMID: 16942632 PMCID: PMC1779601 09/01/2006       30 Citations
  • Spi-1 and Spi-B control the expression of the Grap2 gene in B cells. (Garrett-Sinha LA, Hou P, Wang D, Grabiner B, Araujo E, Rao S, Yun TJ, Clark EA, Simon MC, Clark MR) Gene 2005 Jun 20;353(1):134-46 PMID: 15936902 06/07/2005       12 Citations
  • Spi-B can functionally replace PU.1 in myeloid but not lymphoid development. (Dahl R, Ramirez-Bergeron DL, Rao S, Simon MC) EMBO J 2002 May 01;21(9):2220-30 PMID: 11980719 PMCID: PMC125373 05/01/2002       35 Citations
  • PU.1/Spi-B regulation of c-rel is essential for mature B cell survival. (Hu CJ, Rao S, Ramirez-Bergeron DL, Garrett-Sinha LA, Gerondakis S, Clark MR, Simon MC) Immunity 2001 Oct;15(4):545-55 PMID: 11672537 10/24/2001       38 Citations
  • PU.1 exhibits partial functional redundancy with Spi-B, but not with Ets-1 or Elf-1. (Garrett-Sinha LA, Dahl R, Rao S, Barton KP, Simon MC) Blood 2001 May 01;97(9):2908-12 PMID: 11313289 04/21/2001       44 Citations
  • The Ets factors PU.1 and Spi-B regulate the transcription in vivo of P2Y10, a lymphoid restricted heptahelical receptor. (Rao S, Garrett-Sinha LA, Yoon J, Simon MC) J Biol Chem 1999 Nov 26;274(48):34245-52 PMID: 10567398 11/24/1999       27 Citations
  • PU.1 and Spi-B are required for normal B cell receptor-mediated signal transduction. (Garrett-Sinha LA, Su GH, Rao S, Kabak S, Hao Z, Clark MR, Simon MC) Immunity 1999 Apr;10(4):399-408 PMID: 10229183 05/06/1999       78 Citations
  • SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1. (Rao S, Matsumura A, Yoon J, Simon MC) J Biol Chem 1999 Apr 16;274(16):11115-24 PMID: 10196196 04/10/1999       41 Citations
  • Gel-entrapment bioartificial liver therapy in galactosamine hepatitis. (Sielaff TD, Hu MY, Amiot B, Rollins MD, Rao S, McGuire B, Bloomer JR, Hu WS, Cerra FB) J Surg Res 1995 Jul;59(1):179-84 PMID: 7630125 07/01/1995       73 Citations
  • A technique for porcine hepatocyte harvest and description of differentiated metabolic functions in static culture. (Sielaff TD, Hu MY, Rao S, Groehler K, Olson D, Mann HJ, Remmel RP, Shatford RA, Amiot B, Hu WS) Transplantation 1995 May 27;59(10):1459-63 PMID: 7770934 05/27/1995       56 Citations
  • Ventilatory responses and acute acid-base changes in response to inhaled carbon dioxide in patients with chronic renal failure on long-term haemodialysis. (Gibson GJ, Streeton JA) Respiration 1973;30(5):389-401 PMID: 4751021 01/01/1973       3 Citations
  • Last update: 10/09/2019
    jenkins-FCD Prod-388 89e904233d719332173309c68ab82b0b2a78a3a7