Medical College of Wisconsin
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Vera Tarakanova PhD

Vera Tarakanova PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Microbiology and Molecular Genetics


Publications

  • Nitric Oxide Induces Ataxia Telangiectasia Mutated (ATM) Protein-dependent γH2AX Protein Formation in Pancreatic β Cells. (Oleson BJ, Broniowska KA, Schreiber KH, Tarakanova VL, Corbett JA) J Biol Chem 2014 Apr 18;289(16):11454-64 PMID 24610783
  • Primary macrophages rely on histone deacetylase 1 and 2 expression to induce type I interferon in response to gammaherpesvirus infection. (Mounce BC, Mboko WP, Kanack AJ, Tarakanova VL) J Virol 2014 Feb;88(4):2268-78 PMID 24335310
  • Regulation of antiviral CD8 T-cell responses. (Kulinski JM, Tarakanova VL, Verbsky J) Crit Rev Immunol 2013;33(6):477-88 PMID 24266346
  • Hsp90 inhibitor 17-DMAG decreases expression of conserved herpesvirus protein kinases and reduces virus production in Epstein-Barr virus-infected cells. (Sun X, Bristol JA, Iwahori S, Hagemeier SR, Meng Q, Barlow EA, Fingeroth JD, Tarakanova VL, Kalejta RF, Kenney SC) J Virol 2013 Sep;87(18):10126-38 PMID 23843639
  • Mouse gammaherpesvirus-68 infection acts as a rheostat to set the level of type I interferon signaling in primary macrophages. (Wood BM, Mboko WP, Mounce BC, Tarakanova VL) Virology 2013 Aug 15;443(1):123-33 PMID 23706314
  • A conserved gammaherpesvirus protein kinase targets histone deacetylases 1 and 2 to facilitate viral replication in primary macrophages. (Mounce BC, Mboko WP, Bigley TM, Terhune SS, Tarakanova VL) J Virol 2013 Jul;87(13):7314-25 PMID 23616648
  • Reply to "testing for herpesvirus infection is essential in children with chromosomal-instability syndromes". (Kulinski JM, Tarakanova VL) J Virol 2013 Mar;87(6):3618 PMID 23436902
  • Modulation of B-cell tolerance by murine gammaherpesvirus 68 infection: requirement for Orf73 viral gene expression and follicular helper T cells. (Gauld SB, De Santis JL, Kulinski JM, McGraw JA, Leonardo SM, Ruder EA, Maier W, Tarakanova VL) Immunology 2013 Jun;139(2):197-204 PMID 23311955
  • Ataxia telangiectasia mutated kinase controls chronic gammaherpesvirus infection. (Kulinski JM, Leonardo SM, Mounce BC, Malherbe L, Gauld SB, Tarakanova VL) J Virol 2012 Dec;86(23):12826-37 PMID 22993144
  • Coordinate regulation of DNA damage and type I interferon responses imposes an antiviral state that attenuates mouse gammaherpesvirus type 68 replication in primary macrophages. (Mboko WP, Mounce BC, Wood BM, Kulinski JM, Corbett JA, Tarakanova VL) J Virol 2012 Jun;86(12):6899-912 PMID 22496235
  • Dynamic association of gammaherpesvirus DNA with core histone during de novo lytic infection of primary cells. (Mounce BC, Tsan FC, Kohler S, Cirillo LA, Tarakanova VL) Virology 2011 Dec 20;421(2):167-72 PMID 22018782
  • Gammaherpesvirus gene expression and DNA synthesis are facilitated by viral protein kinase and histone variant H2AX. (Mounce BC, Tsan FC, Droit L, Kohler S, Reitsma JM, Cirillo LA, Tarakanova VL) Virology 2011 Nov 25;420(2):73-81 PMID 21943826
  • Conserved gammaherpesvirus kinase and histone variant H2AX facilitate gammaherpesvirus latency in vivo. (Tarakanova VL, Stanitsa E, Leonardo SM, Bigley TM, Gauld SB) Virology 2010 Sep 15;405(1):50-61 PMID 20557919
  • MHV68 complement regulatory protein facilitates MHV68 replication in primary macrophages in a complement independent manner. (Tarakanova VL, Molleston JM, Goodwin M, Virgin HW 4th) Virology 2010 Jan 20;396(2):323-8 PMID 19910013
  • Adenovirus E1A and E1B-19K proteins protect human hepatoma cells from transforming growth factor beta1-induced apoptosis. (Tarakanova VL, Wold WS) Virus Res 2010 Jan;147(1):67-76 PMID 19854227
  • Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication. (Tarakanova VL, Leung-Pineda V, Hwang S, Yang CW, Matatall K, Basson M, Sun R, Piwnica-Worms H, Sleckman BP, Virgin HW 4th) Cell Host Microbe 2007 Jun 14;1(4):275-86 PMID 18005708
  • Murine gammaherpesvirus 68 genes both induce and suppress lymphoproliferative disease. (Tarakanova VL, Kreisel F, White DW, Virgin HW 4th) J Virol 2008 Jan;82(2):1034-9 PMID 17977975
  • Murine gammaherpesvirus 68 infection is associated with lymphoproliferative disease and lymphoma in BALB beta2 microglobulin-deficient mice. (Tarakanova VL, Suarez F, Tibbetts SA, Jacoby MA, Weck KE, Hess JL, Speck SH, Virgin HW 4th) J Virol 2005 Dec;79(23):14668-79 PMID 16282467
  • Adenovirus DNA binding protein inhibits SrCap-activated CBP and CREB-mediated transcription. (Xu X, Tarakanova V, Chrivia J, Yaciuk P) Virology 2003 Sep 1;313(2):615-21 PMID 12954226
  • Transforming growth factor beta1 receptor II is downregulated by E1A in adenovirus-infected cells. (Tarakanova VL, Wold WS) J Virol 2003 Sep;77(17):9324-36 PMID 12915548
  • Radiation increases the activity of oncolytic adenovirus cancer gene therapy vectors that overexpress the ADP (E3-11.6K) protein. (Toth K, Tarakanova V, Doronin K, Ward P, Kuppuswamy M, Locke JE, Dawson JE, Kim HJ, Wold WS) Cancer Gene Ther 2003 Mar;10(3):193-200 PMID 12637940
  • Grants and Awards

  • Modulation of histone deacetylase activity by a gammaherpesviral kinase (#9208230 08/01/2013 - 07/31/2016) Sponsor: NIH Cancer Institute
  • MOUNCE - Gammaherpesvirus Kinase versus Host Histone Deacetylases: Understanding the Battle (#9208113 07/01/2013 - 06/30/2015) Sponsor: American Heart Association - Midwest Affiliate
  • Gammaherpesvirus Infection and Pathogenesis in Ataxia-Telangiectasia (#9207547 07/01/2012 - 06/30/2016) Sponsor: American Cancer Society National
  • Cancer Center Chemoprevention Program (#9520180 11/01/2010 - 10/31/2016) PI of Manipulation of Oxidative Stress in Gammaherpesvirus Infection (#5520273)
  • Cancer Center Infrastructure Grant (#9520181 11/01/2010 - 10/31/2016) PI of Induction of Type I Interferon Responses by Irradiation: A New Tool for Cancer Therapy (#5520221)