Medical College of Wisconsin
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Yunguang Sun MD, PhD

Yunguang Sun MD, PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Pathology
Division: Administration

Member of the Cancer Center

Publications (51)

  • RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site. (George J, Li Y, Kadamberi IP, Parashar D, Tsaih SW, Gupta P, Geethadevi A, Chen C, Ghosh C, Sun Y, Mittal S, Ramchandran R, Rui H, Lopez-Berestein G, Rodriguez-Aguayo C, Leone G, Rader JS, Sood AK, Dey M, Pradeep S, Chaluvally-Raghavan P) Cell Rep 2023 Mar 07;42(3):112228 PMID: 36884347 SCOPUS ID: 2-s2.0-85149682952 03/09/2023    
  • Collagen-Specific HSP47+ Myofibroblasts and CD163+ Macrophages Identify Profibrotic Phenotypes in Deceased Hearts With SARS-CoV-2 Infections. (Puzyrenko A, Jacobs ER, Padilla N, Devine A, Aljadah M, Gantner BN, Pan AY, Lai S, Dai Q, Rubenstein JC, North PE, Simpson PM, Willoughby RE, O'Meara CC, Flinn MA, Lough JW, Ibrahim EH, Zheng Z, Sun Y, Felix J, Hunt BC, Ross G, Rui H, Benjamin IJ) J Am Heart Assoc 2023 Feb 21;12(4):e027990 PMID: 36789856 SCOPUS ID: 2-s2.0-85148479620 02/16/2023    
  • The DACH1 gene is frequently deleted in prostate cancer, restrains prostatic intraepithelial neoplasia, decreases DNA damage repair, and predicts therapy responses. (Pestell R, Li Z, Jiao X, Robertson A, Sante GD, Ashton A, DiRocco A, Wang M, Zhao J, Addya S, Wang C, McCue P, South A, Cordon-Cardo C, Liu R, Patel K, Hamid R, Parmar J, DuHadaway J, Jones S, Casimiro M, Schultz N, Kossenkov A, Phoon LY, Chen H, Lan L, Sun Y, Iczkowski K, Rui H) Res Sq 2023 Jan 10 PMID: 36712010 PMCID: PMC9882663 01/31/2023    
  • High PD-L2 Predicts Early Recurrence of ER-Positive Breast Cancer. (Chervoneva I, Peck AR, Sun Y, Yi M, Udhane SS, Langenheim JF, Girondo MA, Jorns JM, Chaudhary LN, Kamaraju S, Bergom C, Flister MJ, Hooke JA, Kovatich AJ, Shriver CD, Hu H, Palazzo JP, Bibbo M, Hyslop T, Nevalainen MT, Pestell RG, Fuchs SY, Mitchell EP, Rui H) JCO Precis Oncol 2023 Jan;7:e2100498 PMID: 36652667 PMCID: PMC9928763 01/19/2023    
  • Spatial Metrics of Interaction between CD163-Positive Macrophages and Cancer Cells and Progression-Free Survival in Chemo-Treated Breast Cancer. (Maisel BA, Yi M, Peck AR, Sun Y, Hooke JA, Kovatich AJ, Shriver CD, Hu H, Nevalainen MT, Tanaka T, Simone N, Wang LL, Rui H, Chervoneva I) Cancers (Basel) 2022 Jan 08;14(2) PMID: 35053472 PMCID: PMC8773496 SCOPUS ID: 2-s2.0-85122409008 01/22/2022       3 Citations
  • Cytotoxic CD8-positive T-lymphocyte infiltration in the lungs as a histological pattern of SARS-CoV-2 pneumonitis. (Puzyrenko A, Felix JC, Ledeboer NA, Sun Y, Rui H, Sheinin Y) Pathology 2022 Jun;54(4):404-408 PMID: 34836647 PMCID: PMC8572726 SCOPUS ID: 2-s2.0-85119915379 11/28/2021       1 Citation
  • RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site. (George J, Li Y, Kadamberi IP, Parashar D, Tsaih SW, Gupta P, Geethadevi A, Chen C, Ghosh C, Sun Y, Mittal S, Ramchandran R, Rui H, Lopez-Berestein G, Rodriguez-Aguayo C, Leone G, Rader JS, Sood AK, Dey M, Pradeep S, Chaluvally-Raghavan P) Cell Rep 2021 Nov 02;37(5):109934 PMID: 34731628 PMCID: PMC8675433 SCOPUS ID: 2-s2.0-85118477211 11/04/2021       15 Citations
  • NSG-Pro mouse model for uncovering resistance mechanisms and unique vulnerabilities in human luminal breast cancers. (Sun Y, Yang N, Utama FE, Udhane SS, Zhang J, Peck AR, Yanac A, Duffey K, Langenheim JF, Udhane V, Xia G, Peterson JF, Jorns JM, Nevalainen MT, Rouet R, Schofield P, Christ D, Ormandy CJ, Rosenberg AL, Chervoneva I, Tsaih SW, Flister MJ, Fuchs SY, Wagner KU, Rui H) Sci Adv 2021 Sep 17;7(38):eabc8145 PMID: 34524841 PMCID: PMC8443188 SCOPUS ID: 2-s2.0-85115168052 09/16/2021       3 Citations
  • Pneumocytes are distinguished by highly elevated expression of the ER stress biomarker GRP78, a co-receptor for SARS-CoV-2, in COVID-19 autopsies. (Puzyrenko A, Jacobs ER, Sun Y, Felix JC, Sheinin Y, Ge L, Lai S, Dai Q, Gantner BN, Nanchal R, North PE, Simpson PM, Rui H, Benjamin IJ) Cell Stress Chaperones 2021 Sep;26(5):859-868 PMID: 34382151 PMCID: PMC8357488 SCOPUS ID: 2-s2.0-85112285201 08/13/2021       10 Citations
  • Oncostatin M Receptor-Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth. (Geethadevi A, Nair A, Parashar D, Ku Z, Xiong W, Deng H, Li Y, George J, McAllister DM, Sun Y, Kadamberi IP, Gupta P, Dwinell MB, Bradley WH, Rader JS, Rui H, Schwabe RF, Zhang N, Pradeep S, An Z, Chaluvally-Raghavan P) Cancer Res 2021 Oct 15;81(20):5336-5352 PMID: 34380633 PMCID: PMC8530981 SCOPUS ID: 2-s2.0-85116424540 08/13/2021       15 Citations
  • Sensitive and Specific Immunohistochemistry Protocol for Nucleocapsid Protein from All Common SARS-CoV-2 Virus Strains in Formalin-Fixed, Paraffin Embedded Tissues. (Sun Y, Ge L, Udhane SS, Langenheim JF, Rau MJ, Patton MD, Gallan AJ, Felix JC, Rui H) Methods Protoc 2021 Jul 10;4(3) PMID: 34287344 PMCID: PMC8293419 SCOPUS ID: 2-s2.0-85111011758 07/22/2021       5 Citations
  • Regulation of intercellular biomolecule transfer-driven tumor angiogenesis and responses to anticancer therapies. (Lu Z, Ortiz A, Verginadis II, Peck AR, Zahedi F, Cho C, Yu P, DeRita RM, Zhang H, Kubanoff R, Sun Y, Yaspan AT, Krespan E, Beiting DP, Radaelli E, Ryeom SW, Diehl JA, Rui H, Koumenis C, Fuchs SY) J Clin Invest 2021 May 17;131(10) PMID: 33998600 PMCID: PMC8121529 SCOPUS ID: 2-s2.0-85106569543 05/18/2021       7 Citations
  • Diffuse interstitial pneumonia-like/macrophage activation syndrome-like changes in patients with COVID-19 correlate with length of illness. (Felix JC, Sheinin YM, Suster D, Ronen N, Ratiani M, Vanden Heuvel T, Winge E, Patton MD, Rau MJ, Ge L, Sun Y, Udhane SS, Langenheim JF, Rui H) Ann Diagn Pathol 2021 Aug;53:151744 PMID: 33991784 PMCID: PMC8053602 SCOPUS ID: 2-s2.0-85105597450 05/16/2021       2 Citations
  • Acute SARS-CoV-2 pneumonitis with cytotoxic CD8 positive T-lymphocytes: Case report and review of the literature. (Puzyrenko A, Felix JC, Sun Y, Rui H, Sheinin Y) Pathol Res Pract 2021 Apr;220:153380 PMID: 33676105 PMCID: PMC7883708 SCOPUS ID: 2-s2.0-85101878778 03/07/2021       5 Citations
  • Safety of apatinib plus S-1 for advanced solid tumor as palliative treatment. (Chen S, Sun J, Zhao L, Sun Y, Jia D, Song Y, Luo J, Lei H, Liu N) Exp Ther Med 2021 Jan;21(1):62 PMID: 33365062 PMCID: PMC7716638 12/29/2020    
  • The membrane-associated form of cyclin D1 enhances cellular invasion. (Chen K, Jiao X, Ashton A, Di Rocco A, Pestell TG, Sun Y, Zhao J, Casimiro MC, Li Z, Lisanti MP, McCue PA, Shen D, Achilefu S, Rui H, Pestell RG) Oncogenesis 2020 Sep 18;9(9):83 PMID: 32948740 PMCID: PMC7501870 SCOPUS ID: 2-s2.0-85091177817 09/20/2020       10 Citations
  • Cancer-associated fibroblasts downregulate type I interferon receptor to stimulate intratumoral stromagenesis. (Cho C, Mukherjee R, Peck AR, Sun Y, McBrearty N, Katlinski KV, Gui J, Govindaraju PK, Puré E, Rui H, Fuchs SY) Oncogene 2020 Sep;39(38):6129-6137 PMID: 32807917 PMCID: PMC7502515 SCOPUS ID: 2-s2.0-85089539324 08/19/2020       12 Citations
  • Malignant cell-specific pro-tumorigenic role of type I interferon receptor in breast cancers. (Odnokoz O, Yu P, Peck AR, Sun Y, Kovatich AJ, Hooke JA, Hu H, Mitchell EP, Rui H, Fuchs SY) Cancer Biol Ther 2020 Jul 02;21(7):629-636 PMID: 32378445 PMCID: PMC7515508 SCOPUS ID: 2-s2.0-85084376942 05/08/2020       4 Citations
  • Acquired Immunity Is Not Essential for Radiation-Induced Heart Dysfunction but Exerts a Complex Impact on Injury. (Schlaak RA, Frei A, Fish BL, Harmann L, Gasperetti T, Pipke JL, Sun Y, Rui H, Flister MJ, Gantner BN, Bergom C) Cancers (Basel) 2020 Apr 16;12(4) PMID: 32316187 PMCID: PMC7226421 SCOPUS ID: 2-s2.0-85083724334 04/23/2020       4 Citations
  • Inhibition of Aurora A enhances radiosensitivity in selected lung cancer cell lines. (Liu N, Wang YA, Sun Y, Ecsedy J, Sun J, Li X, Wang P) Respir Res 2019 Oct 23;20(1):230 PMID: 31647033 PMCID: PMC6813099 SCOPUS ID: 2-s2.0-85074065855 10/28/2019       16 Citations
  • The p52 isoform of SHC1 is a key driver of breast cancer initiation. (Wright KD, Miller BS, El-Meanawy S, Tsaih SW, Banerjee A, Geurts AM, Sheinin Y, Sun Y, Kalyanaraman B, Rui H, Flister MJ, Sorokin A) Breast Cancer Res 2019 Jun 15;21(1):74 PMID: 31202267 PMCID: PMC6570928 SCOPUS ID: 2-s2.0-85067234098 06/17/2019       19 Citations
  • Neuronatin is a modifier of estrogen receptor-positive breast cancer incidence and outcome. (Plasterer C, Tsaih SW, Peck AR, Chervoneva I, O'Meara C, Sun Y, Lemke A, Murphy D, Smith J, Ran S, Kovatich AJ, Hooke JA, Shriver CD, Hu H, Mitchell EP, Bergom C, Joshi A, Auer P, Prokop J, Rui H, Flister MJ) Breast Cancer Res Treat 2019 Aug;177(1):77-91 PMID: 31165373 SCOPUS ID: 2-s2.0-85066986189 06/06/2019       1 Citation
  • Mapping genetic modifiers of radiation-induced cardiotoxicity to rat chromosome 3. (Schlaak RA, Frei A, Schottstaedt AM, Tsaih SW, Fish BL, Harmann L, Liu Q, Gasperetti T, Medhora M, North PE, Strande JL, Sun Y, Rui H, Flister MJ, Bergom C) Am J Physiol Heart Circ Physiol 2019 Jun 01;316(6):H1267-H1280 PMID: 30848680 PMCID: PMC6620678 SCOPUS ID: 2-s2.0-85066837925 03/09/2019       24 Citations
  • Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells. (Gennaro VJ, Stanek TJ, Peck AR, Sun Y, Wang F, Qie S, Knudsen KE, Rui H, Butt T, Diehl JA, McMahon SB) Proc Natl Acad Sci U S A 2018 Oct 02;115(40):E9298-E9307 PMID: 30224477 PMCID: PMC6176615 SCOPUS ID: 2-s2.0-85054360749 09/19/2018       62 Citations
  • Loss of Nuclear Localized Parathyroid Hormone-Related Protein in Primary Breast Cancer Predicts Poor Clinical Outcome and Correlates with Suppressed Stat5 Signaling. (Tran TH, Utama FE, Sato T, Peck AR, Langenheim JF, Udhane SS, Sun Y, Liu C, Girondo MA, Kovatich AJ, Hooke JA, Shriver CD, Hu H, Palazzo JP, Bibbo M, Auer PW, Flister MJ, Hyslop T, Mitchell EP, Chervoneva I, Rui H) Clin Cancer Res 2018 Dec 15;24(24):6355-6366 PMID: 30097435 SCOPUS ID: 2-s2.0-85058487046 08/12/2018       9 Citations
  • SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression. (Gonyo P, Bergom C, Brandt AC, Tsaih SW, Sun Y, Bigley TM, Lorimer EL, Terhune SS, Rui H, Flister MJ, Long RM, Williams CL) Oncogene 2017 Dec 14;36(50):6873-6883 PMID: 28806394 PMCID: PMC5730474 SCOPUS ID: 2-s2.0-85038242723 08/15/2017       10 Citations
  • IGFBP3 Modulates Lung Tumorigenesis and Cell Growth through IGF1 Signaling. (Wang YA, Sun Y, Palmer J, Solomides C, Huang LC, Shyr Y, Dicker AP, Lu B) Mol Cancer Res 2017 Jul;15(7):896-904 PMID: 28330997 SCOPUS ID: 2-s2.0-85021820717 03/24/2017       37 Citations
  • Nitrilase 1 modulates lung tumor progression in vitro and in vivo. (Wang YA, Sun Y, Le Blanc JM, Solomides C, Zhan T, Lu B) Oncotarget 2016 Apr 19;7(16):21381-92 PMID: 26967383 PMCID: PMC5008292 SCOPUS ID: 2-s2.0-84965043210 03/12/2016       4 Citations
  • Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung cancer cells in vitro. (Liu N, Tao Z, Blanc JM, Zaorsky NG, Sun Y, Vuagniaux G, Dicker AP, Lu B) Am J Cancer Res 2014;4(6):943-51 PMID: 25520882 PMCID: PMC4266726 12/19/2014    
  • Stable and efficient transfection of siRNA for mutated KRAS silencing using novel hybrid nanoparticles. (Lakshmikuttyamma A, Sun Y, Lu B, Undieh AS, Shoyele SA) Mol Pharm 2014 Dec 01;11(12):4415-24 PMID: 25340957 SCOPUS ID: 2-s2.0-84914115620 10/24/2014       20 Citations
  • Assessment of M867, a selective caspase-3 inhibitor, in an orthotopic mouse model for non-small cell lung carcinoma. (Li B, Blanc JM, Sun Y, Yang L, Zaorsky NG, Giacalone NJ, Torossian A, Lu B) Am J Cancer Res 2014;4(2):161-71 PMID: 24660105 PMCID: PMC3960453 03/25/2014    
  • A novel radiation-induced p53 mutation is not implicated in radiation resistance via a dominant-negative effect. (Sun Y, Myers CJ, Dicker AP, Lu B) PLoS One 2014;9(2):e87492 PMID: 24558369 PMCID: PMC3928108 SCOPUS ID: 2-s2.0-84895862089 02/22/2014       3 Citations
  • Identification of a KRAS mutation in a patient with non-small cell lung cancer treated with chemoradiotherapy and panitumumab. (Zaorsky NG, Sun Y, Wang Z, Palmer J, Fortina PM, Solomides C, Werner-Wasik M, Dicker AP, Axelrod R, Campling B, Evans N 3rd, Cowan S, Lu B) Cancer Biol Ther 2013 Oct 01;14(10):883-7 PMID: 23917487 PMCID: PMC3926884 SCOPUS ID: 2-s2.0-84885216119 08/07/2013       3 Citations
  • ALK inhibitor PF02341066 (crizotinib) increases sensitivity to radiation in non-small cell lung cancer expressing EML4-ALK. (Sun Y, Nowak KA, Zaorsky NG, Winchester CL, Dalal K, Giacalone NJ, Liu N, Werner-Wasik M, Wasik MA, Dicker AP, Lu B) Mol Cancer Ther 2013 May;12(5):696-704 PMID: 23443800 PMCID: PMC3651772 SCOPUS ID: 2-s2.0-84877672976 02/28/2013       46 Citations
  • PA1 protein, a new competitive decelerator acting at more than one step to impede glucocorticoid receptor-mediated transactivation. (Zhang Z, Sun Y, Cho YW, Chow CC, Simons SS Jr) J Biol Chem 2013 Jan 04;288(1):42-58 PMID: 23161582 PMCID: PMC3537039 SCOPUS ID: 2-s2.0-84872069513 11/20/2012       19 Citations
  • Higher levels of c-Met expression and phosphorylation identify cell lines with increased sensitivity to AMG-458, a novel selective c-Met inhibitor with radiosensitizing effects. (Li B, Torossian A, Sun Y, Du R, Dicker AP, Lu B) Int J Radiat Oncol Biol Phys 2012 Nov 15;84(4):e525-31 PMID: 22836051 SCOPUS ID: 2-s2.0-84872045438 07/28/2012       17 Citations
  • Role of insulin-like growth factor-1 signaling pathway in cisplatin-resistant lung cancer cells. (Sun Y, Zheng S, Torossian A, Speirs CK, Schleicher S, Giacalone NJ, Carbone DP, Zhao Z, Lu B) Int J Radiat Oncol Biol Phys 2012 Mar 01;82(3):e563-72 PMID: 22197230 PMCID: PMC3271860 SCOPUS ID: 2-s2.0-84856398941 12/27/2011       58 Citations
  • BV6, an IAP antagonist, activates apoptosis and enhances radiosensitization of non-small cell lung carcinoma in vitro. (Li W, Li B, Giacalone NJ, Torossian A, Sun Y, Niu K, Lin-Tsai O, Lu B) J Thorac Oncol 2011 Nov;6(11):1801-9 PMID: 21760551 PMCID: PMC3196825 07/16/2011    
  • Inhibition of JAK2 signaling by TG101209 enhances radiotherapy in lung cancer models. (Sun Y, Moretti L, Giacalone NJ, Schleicher S, Speirs CK, Carbone DP, Lu B) J Thorac Oncol 2011 Apr;6(4):699-706 PMID: 21325979 PMCID: PMC3104103 02/18/2011    
  • Enhanced radiosensitivity of androgen-resistant prostate cancer: AZD1152-mediated Aurora kinase B inhibition. (Niermann KJ, Moretti L, Giacalone NJ, Sun Y, Schleicher SM, Kopsombut P, Mitchell LR, Kim KW, Lu B) Radiat Res 2011 Apr;175(4):444-51 PMID: 21222513 PMCID: PMC3133747 SCOPUS ID: 2-s2.0-79953297717 01/13/2011       27 Citations
  • Terameprocol (tetra-O-methyl nordihydroguaiaretic acid), an inhibitor of Sp1-mediated survivin transcription, induces radiosensitization in non-small cell lung carcinoma. (Sun Y, Giacalone NJ, Lu B) J Thorac Oncol 2011 Jan;6(1):8-14 PMID: 21107289 PMCID: PMC3010256 11/26/2010    
  • Targeting the mechanisms of resistance to chemotherapy and radiotherapy with the cancer stem cell hypothesis. (Morrison R, Schleicher SM, Sun Y, Niermann KJ, Kim S, Spratt DE, Chung CH, Lu B) J Oncol 2011;2011:941876 PMID: 20981352 PMCID: PMC2958340 SCOPUS ID: 2-s2.0-78349234668 10/29/2010       167 Citations
  • Modulation of transcription parameters in glucocorticoid receptor-mediated repression. (Sun Y, Tao YG, Kagan BL, He Y, Simons SS Jr) Mol Cell Endocrinol 2008 Nov 25;295(1-2):59-69 PMID: 18583028 PMCID: PMC2662735 SCOPUS ID: 2-s2.0-48949094973 06/28/2008       24 Citations
  • Effects of acetylation, polymerase phosphorylation, and DNA unwinding in glucocorticoid receptor transactivation. (Kim Y, Sun Y, Chow C, Pommier YG, Simons SS Jr) J Steroid Biochem Mol Biol 2006 Jul;100(1-3):3-17 PMID: 16723222 SCOPUS ID: 2-s2.0-33746030006 05/26/2006       23 Citations
  • Protective Effect of Clonidine against Toxicity of Organophosphorus Pesticides (Zhijun Zhou, Yunping Hu, Yunguang Sun, Jia Chen) Journal of Occupational Health Zhou, Z., Hu, Y., Sun, Y. and Chen, J. (2001), Protective Effect of Clonidine against Toxicity of Organophosphorus Pesticides. Journal of Occupational Health, 43: 346-350. 04/07/2006    
  • Memantine alleviates toxicity induced by dichlorvos in rats. (Zhou Z, Dai X, Gu X, Sun Y, Zheng G, Zheng J) J Occup Health 2005 Mar;47(2):96-101 PMID: 15824473 SCOPUS ID: 2-s2.0-17644410335 04/13/2005       11 Citations
  • [Protective effect of memantine on N-methyl-D-aspartate receptor in dichlorvos-poisoned rat brain]. (Dai XF, Zhou ZJ, Gu XA, Sun YG, Zheng G, Zheng J) Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2004 Feb;22(1):11-4 PMID: 15033007 SCOPUS ID: 2-s2.0-4243101467 03/23/2004       2 Citations
  • [Muscarine receptor gene expression in brain and peripheral blood lymphocytes of rats pretreated with dimethoate for 28 days]. (Sun YG, Zhou ZJ, Zhang XM, Gu XA, Jin TY) Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2004 Feb;22(1):7-10 PMID: 15033006 SCOPUS ID: 2-s2.0-4243090254 03/23/2004    
  • [Expression of M3 receptor gene in peripheral blood lymphocytes of workers exposed to dimethoate]. (Sun YG, Zhou ZJ, Zhang XM, Gu XA, Jin TY) Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2004 Feb;22(1):3-6 PMID: 15033005 SCOPUS ID: 2-s2.0-4243190110 03/23/2004       1 Citation
  • [The acute effects of dimethoate on the muscarinic-receptors of rat brains and the relationship between muscarinic-receptors and cholinesterase]. (Sun Y, Zhou Z, Hu Y, Chen J, Jin T) Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2002 Aug;20(4):293-5 PMID: 14694657 SCOPUS ID: 2-s2.0-46649103488 12/26/2003    
  • Protective effect of clonidine against toxicity of organophosphorus pesticides (Zhou Z, Hu Y, Sun Y, Chen J) Journal of Occupational Health 2001;43(6):346-350 SCOPUS ID: 2-s2.0-0035674098 01/01/2001       6 Citations
  • Last update: 03/24/2023