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Jacek M. Zielonka PhD

Jacek M. Zielonka PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Biophysics
Program: Research

Member of the Cancer Center


Research Experience

  • Antioxidants
  • Boronic Acids
  • Cell Line, Tumor
  • Cell Proliferation
  • Cyclic N-Oxides
  • Cytochromes c
  • Energy Metabolism
  • Enzyme Inhibitors
  • Ethidium
  • Fluorescent Dyes
  • Free Radical Scavengers
  • Free Radicals
  • Glutathione
  • Glycolysis
  • HL-60 Cells
  • High-Throughput Screening Assays
  • Hydrogen Peroxide
  • Hypochlorous Acid
  • Kinetics
  • Mitochondria
  • Molecular Probes
  • NADPH Oxidase 2
  • NADPH Oxidases
  • Nitric Oxide
  • Nitrogen Oxides
  • Oxidants
  • Oxidation-Reduction
  • Oxidative Stress
  • Oxygen Consumption
  • Paraquat
  • Peroxidase
  • Peroxynitrous Acid
  • Phenanthridines
  • Pyridines
  • Reactive Nitrogen Species
  • Reactive Oxygen Species
  • Superoxides
  • Xanthine Oxidase
  • Methodologies and Techniques

  • Blotting, Western
  • Chromatography, High Pressure Liquid
  • Electron Spin Resonance Spectroscopy
  • Fluorescence
  • Fluorometry
  • High-Throughput Screening Assays
  • Luminescence
  • Luminescent Measurements
  • Mass Spectrometry
  • Pulse Radiolysis
  • Spectrophotometry
  • Spectrophotometry, Ultraviolet
  • Spin Trapping
  • Publications

  • Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity. (Pan J, Lee Y, Cheng G, Zielonka J, Zhang Q, Bajzikova M, Xiong D, Tsaih SW, Hardy M, Flister M, Olsen CM, Wang Y, Vang O, Neuzil J, Myers CR, Kalyanaraman B, You M) iScience 2018 May 25;3:192-207 PMID: 30428319 PMCID: PMC6137433 11/15/2018    
  • Foreword to the Free Radical Biology and Medicine Special Issue on ¨Current fluorescence and chemiluminescence approaches in free radical and redox biology¨. (Radi R, Denicola A, Morgan B, Zielonka J) Free Radic Biol Med 2018 Nov 20;128:1-2 PMID: 30293645 10/09/2018    
  • Low-Temperature EPR Spectroscopy as a Probe-Free Technique for Monitoring Oxidants Formed in Tumor Cells and Tissues: Implications in Drug Resistance and OXPHOS-Targeted Therapies. (Kalyanaraman B, Cheng G, Zielonka J, Bennett B) Cell Biochem Biophys 2018 Sep 26 PMID: 30259334 09/28/2018    
  • Detection of mitochondria-generated reactive oxygen species in cells using multiple probes and methods: Potentials, pitfalls, and the future. (Cheng G, Zielonka M, Dranka B, Kumar SN, Myers CR, Bennett B, Garces AM, Dias Duarte Machado LG, Thiebaut D, Ouari O, Hardy M, Zielonka J, Kalyanaraman B) J Biol Chem 2018 06 29;293(26):10363-10380 PMID: 29739855 PMCID: PMC6028982 05/10/2018       3 Citations
  • Kindlin-3 negatively regulates the release of neutrophil extracellular traps. (Xu Z, Ni B, Cao Z, Zielonka J, Gao J, Chen F, Kalyanaraman B, White GC, Ma YQ) J Leukoc Biol 2018 Sep;104(3):597-602 PMID: 29656482 PMCID: PMC6113072 04/16/2018    
  • Small-molecule luminescent probes for the detection of cellular oxidizing and nitrating species. (Zielonka J, Kalyanaraman B) Free Radic Biol Med 2018 Nov 20;128:3-22 PMID: 29567392 PMCID: PMC6146080 03/24/2018       3 Citations
  • Corrigendum to 'A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds' [REDOX 14C (2017) 316-327]. (Kalyanaraman B, Cheng G, Hardy M, Ouari O, Lopez M, Joseph J, Zielonka J, Dwinell MB) Redox Biol 2018 06;16:426-427 PMID: 29548725 PMCID: PMC5952812 03/20/2018    
  • Teaching the basics of reactive oxygen species and their relevance to cancer biology: Mitochondrial reactive oxygen species detection, redox signaling, and targeted therapies. (Kalyanaraman B, Cheng G, Hardy M, Ouari O, Bennett B, Zielonka J) Redox Biol 2018 05;15:347-362 PMID: 29306792 PMCID: PMC5756055 01/08/2018       12 Citations
  • Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162]. (Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, Ademowo OS, Afonso CB, Andreadou I, Antelmann H, Antunes F, Aslan M, Bachschmid MM, Barbosa RM, Belousov V, Berndt C, Bernlohr D, Bertrán E, Bindoli A, Bottari SP, Brito PM, Carrara G, Casas AI, Chatzi A, Chondrogianni N, Conrad M, Cooke MS, Costa JG, Cuadrado A, My-Chan Dang P, De Smet B, Debelec-Butuner B, Dias IHK, Dunn JD, Edson AJ, El Assar M, El-Benna J, Ferdinandy P, Fernandes AS, Fladmark KE, Förstermann U, Giniatullin R, Giricz Z, Görbe A, Griffiths H, Hampl V, Hanf A, Herget J, Hernansanz-Agustín P, Hillion M, Huang J, Ilikay S, Jansen-Dürr P, Jaquet V, Joles JA, Kalyanaraman B, Kaminskyy D, Karbaschi M, Kleanthous M, Klotz LO, Korac B, Korkmaz KS, Koziel R, Kračun D, Krause KH, Křen V, Krieg T, Laranjinha J, Lazou A, Li H, Martínez-Ruiz A, Matsui R, McBean GJ, Meredith SP, Messens J, Miguel V, Mikhed Y, Milisav I, Milković L, Miranda-Vizuete A, Mojović M, Monsalve M, Mouthuy PA, Mulvey J, Münzel T, Muzykantov V, Nguyen ITN, Oelze M, Oliveira NG, Palmeira CM, Papaevgeniou N, Pavićević A, Pedre B, Peyrot F, Phylactides M, Pircalabioru GG, Pitt AR, Poulsen HE, Prieto I, Rigobello MP, Robledinos-Antón N, Rodríguez-Mañas L, Rolo AP, Rousset F, Ruskovska T, Saraiva N, Sasson S, Schröder K, Semen K, Seredenina T, Shakirzyanova A, Smith GL, Soldati T, Sousa BC, Spickett CM, Stancic A, Stasia MJ, Steinbrenner H, Stepanić V, Steven S, Tokatlidis K, Tuncay E, Turan B, Ursini F, Vacek J, Vajnerova O, Valentová K, Van Breusegem F, Varisli L, Veal EA, Yalçın AS, Yelisyeyeva O, Žarković N, Zatloukalová M, Zielonka J, Touyz RM, Papapetropoulos A, Grune T, Lamas S, Schmidt HHHW, Di Lisa F, Daiber A) Redox Biol 2018 04;14:694-696 PMID: 29107648 PMCID: PMC5975209 11/07/2017    
  • Detection and Characterization of Reactive Oxygen and Nitrogen Species in Biological Systems by Monitoring Species-Specific Products. (Hardy M, Zielonka J, Karoui H, Sikora A, Michalski R, Podsiadły R, Lopez M, Vasquez-Vivar J, Kalyanaraman B, Ouari O) Antioxid Redox Signal 2018 May 20;28(15):1416-1432 PMID: 29037049 PMCID: PMC5910052 10/19/2017    
  • A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds. (Kalyanaraman B, Cheng G, Hardy M, Ouari O, Lopez M, Joseph J, Zielonka J, Dwinell MB) Redox Biol 2018 04;14:316-327 PMID: 29017115 PMCID: PMC5633086 10/11/2017       18 Citations
  • Recent Developments in the Probes and Assays for Measurement of the Activity of NADPH Oxidases. (Zielonka J, Hardy M, Michalski R, Sikora A, Zielonka M, Cheng G, Ouari O, Podsiadły R, Kalyanaraman B) Cell Biochem Biophys 2017 Dec;75(3-4):335-349 PMID: 28660426 PMCID: PMC5693611 07/01/2017       4 Citations
  • Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications. (Zielonka J, Joseph J, Sikora A, Hardy M, Ouari O, Vasquez-Vivar J, Cheng G, Lopez M, Kalyanaraman B) Chem Rev 2017 Aug 09;117(15):10043-10120 PMID: 28654243 PMCID: PMC5611849 06/28/2017       84 Citations
  • European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). (Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, Ademowo OS, Afonso CB, Andreadou I, Antelmann H, Antunes F, Aslan M, Bachschmid MM, Barbosa RM, Belousov V, Berndt C, Bernlohr D, Bertrán E, Bindoli A, Bottari SP, Brito PM, Carrara G, Casas AI, Chatzi A, Chondrogianni N, Conrad M, Cooke MS, Costa JG, Cuadrado A, My-Chan Dang P, De Smet B, Debelec-Butuner B, Dias IHK, Dunn JD, Edson AJ, El Assar M, El-Benna J, Ferdinandy P, Fernandes AS, Fladmark KE, Förstermann U, Giniatullin R, Giricz Z, Görbe A, Griffiths H, Hampl V, Hanf A, Herget J, Hernansanz-Agustín P, Hillion M, Huang J, Ilikay S, Jansen-Dürr P, Jaquet V, Joles JA, Kalyanaraman B, Kaminskyy D, Karbaschi M, Kleanthous M, Klotz LO, Korac B, Korkmaz KS, Koziel R, Kračun D, Krause KH, Křen V, Krieg T, Laranjinha J, Lazou A, Li H, Martínez-Ruiz A, Matsui R, McBean GJ, Meredith SP, Messens J, Miguel V, Mikhed Y, Milisav I, Milković L, Miranda-Vizuete A, Mojović M, Monsalve M, Mouthuy PA, Mulvey J, Münzel T, Muzykantov V, Nguyen ITN, Oelze M, Oliveira NG, Palmeira CM, Papaevgeniou N, Pavićević A, Pedre B, Peyrot F, Phylactides M, Pircalabioru GG, Pitt AR, Poulsen HE, Prieto I, Rigobello MP, Robledinos-Antón N, Rodríguez-Mañas L, Rolo AP, Rousset F, Ruskovska T, Saraiva N, Sasson S, Schröder K, Semen K, Seredenina T, Shakirzyanova A, Smith GL, Soldati T, Sousa BC, Spickett CM, Stancic A, Stasia MJ, Steinbrenner H, Stepanić V, Steven S, Tokatlidis K, Tuncay E, Turan B, Ursini F, Vacek J, Vajnerova O, Valentová K, Van Breusegem F, Varisli L, Veal EA, Yalçın AS, Yelisyeyeva O, Žarković N, Zatloukalová M, Zielonka J, Touyz RM, Papapetropoulos A, Grune T, Lamas S, Schmidt HHHW, Di Lisa F, Daiber A) Redox Biol 2017 10;13:94-162 PMID: 28577489 PMCID: PMC5458069 06/04/2017       48 Citations
  • Modified Metformin as a More Potent Anticancer Drug: Mitochondrial Inhibition, Redox Signaling, Antiproliferative Effects and Future EPR Studies. (Kalyanaraman B, Cheng G, Hardy M, Ouari O, Sikora A, Zielonka J, Dwinell MB) Cell Biochem Biophys 2017 Dec;75(3-4):311-317 PMID: 28429253 PMCID: PMC5680142 04/22/2017       6 Citations
  • Green fluorescent proteins induce oxidative stress in cells: A worrisome new wrinkle in the application of the GFP reporter system to biological systems? (Kalyanaraman B, Zielonka J) Redox Biol 2017 08;12:755-757 PMID: 28415040 PMCID: PMC5397015 04/18/2017    
  • Mitochondria-targeted metformins: anti-tumour and redox signalling mechanisms. (Kalyanaraman B, Cheng G, Hardy M, Ouari O, Sikora A, Zielonka J, Dwinell M) Interface Focus 2017 Apr 06;7(2):20160109 PMID: 28382202 PMCID: PMC5311906 04/07/2017    
  • Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice. (Langley M, Ghosh A, Charli A, Sarkar S, Ay M, Luo J, Zielonka J, Brenza T, Bennett B, Jin H, Ghaisas S, Schlichtmann B, Kim D, Anantharam V, Kanthasamy A, Narasimhan B, Kalyanaraman B, Kanthasamy AG) Antioxid Redox Signal 2017 Nov 10;27(14):1048-1066 PMID: 28375739 PMCID: PMC5651937 04/05/2017       17 Citations
  • A Critical Review of Methodologies to Detect Reactive Oxygen and Nitrogen Species Stimulated by NADPH Oxidase Enzymes: Implications in Pesticide Toxicity. (Kalyanaraman B, Hardy M, Zielonka J) Curr Pharmacol Rep 2016 Aug;2(4):193-201 PMID: 27774407 PMCID: PMC5070669 10/25/2016    
  • On the use of peroxy-caged luciferin (PCL-1) probe for bioluminescent detection of inflammatory oxidants in vitro and in vivo - Identification of reaction intermediates and oxidant-specific minor products. (Zielonka J, Podsiadły R, Zielonka M, Hardy M, Kalyanaraman B) Free Radic Biol Med 2016 10;99:32-42 PMID: 27458121 PMCID: PMC5107150 10/23/2016       10 Citations
  • Recent developments in detection of superoxide radical anion and hydrogen peroxide: Opportunities, challenges, and implications in redox signaling. (Kalyanaraman B, Hardy M, Podsiadly R, Cheng G, Zielonka J) Arch Biochem Biophys 2017 Mar 01;617:38-47 PMID: 27590268 PMCID: PMC5318280 09/04/2016       24 Citations
  • Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells. (Cheng G, Zielonka J, Ouari O, Lopez M, McAllister D, Boyle K, Barrios CS, Weber JJ, Johnson BD, Hardy M, Dwinell MB, Kalyanaraman B) Cancer Res 2016 07 01;76(13):3904-15 PMID: 27216187 PMCID: PMC4930686 05/25/2016       40 Citations
  • Mechanism of oxidative conversion of Amplex® Red to resorufin: Pulse radiolysis and enzymatic studies. (Dębski D, Smulik R, Zielonka J, Michałowski B, Jakubowska M, Dębowska K, Adamus J, Marcinek A, Kalyanaraman B, Sikora A) Free Radic Biol Med 2016 06;95:323-32 PMID: 27021961 PMCID: PMC5697983 03/30/2016       25 Citations
  • Mitigation of NADPH Oxidase 2 Activity as a Strategy to Inhibit Peroxynitrite Formation. (Zielonka J, Zielonka M, VerPlank L, Cheng G, Hardy M, Ouari O, Ayhan MM, Podsiadły R, Sikora A, Lambeth JD, Kalyanaraman B) J Biol Chem 2016 Mar 25;291(13):7029-44 PMID: 26839313 PMCID: PMC4807286 02/04/2016       28 Citations
  • Toward selective detection of reactive oxygen and nitrogen species with the use of fluorogenic probes--Limitations, progress, and perspectives. (Debowska K, Debski D, Hardy M, Jakubowska M, Kalyanaraman B, Marcinek A, Michalski R, Michalowski B, Ouari O, Sikora A, Smulik R, Zielonka J) Pharmacol Rep 2015 Aug;67(4):756-64 PMID: 26321278 PMCID: PMC5793900 09/01/2015       24 Citations
  • Antiproliferative effects of mitochondria-targeted cationic antioxidants and analogs: Role of mitochondrial bioenergetics and energy-sensing mechanism. (Cheng G, Zielonka J, McAllister D, Hardy M, Ouari O, Joseph J, Dwinell MB, Kalyanaraman B) Cancer Lett 2015 Aug 28;365(1):96-106 PMID: 26004344 PMCID: PMC4476640 05/26/2015       22 Citations
  • Detection and differentiation between peroxynitrite and hydroperoxides using mitochondria-targeted arylboronic acid. (Zielonka J, Sikora A, Adamus J, Kalyanaraman B) Methods Mol Biol 2015;1264:171-81 PMID: 25631013 PMCID: PMC4451192 01/30/2015       12 Citations
  • Nitroxyl (HNO) reacts with molecular oxygen and forms peroxynitrite at physiological pH. Biological Implications. (Smulik R, Dębski D, Zielonka J, Michałowski B, Adamus J, Marcinek A, Kalyanaraman B, Sikora A) J Biol Chem 2014 Dec 19;289(51):35570-81 PMID: 25378389 PMCID: PMC4271240 11/08/2014       32 Citations
  • A novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic mouse model of Parkinson's disease. (Dranka BP, Gifford A, McAllister D, Zielonka J, Joseph J, O'Hara CL, Stucky CL, Kanthasamy AG, Kalyanaraman B) Neurosci Lett 2014 Nov 07;583:159-64 PMID: 25263790 PMCID: PMC4253647 09/30/2014       17 Citations
  • Real-time measurements of amino acid and protein hydroperoxides using coumarin boronic acid. (Michalski R, Zielonka J, Gapys E, Marcinek A, Joseph J, Kalyanaraman B) J Biol Chem 2014 Aug 08;289(32):22536-53 PMID: 24928516 PMCID: PMC4139259 06/15/2014       30 Citations
  • H2O2 generation by bacillus Calmette-Guérin induces the cellular oxidative stress response required for bacillus Calmette-Guérin direct effects on urothelial carcinoma biology. (Shah G, Zielonka J, Chen F, Zhang G, Cao Y, Kalyanaraman B, See W) J Urol 2014 Oct;192(4):1238-48 PMID: 24928267 PMCID: PMC5798233 06/15/2014       7 Citations
  • Mitochondria-targeted spin traps: synthesis, superoxide spin trapping, and mitochondrial uptake. (Hardy M, Poulhés F, Rizzato E, Rockenbauer A, Banaszak K, Karoui H, Lopez M, Zielonka J, Vasquez-Vivar J, Sethumadhavan S, Kalyanaraman B, Tordo P, Ouari O) Chem Res Toxicol 2014 Jul 21;27(7):1155-65 PMID: 24890552 PMCID: PMC5452977 06/04/2014       13 Citations
  • Profiling and targeting of cellular bioenergetics: inhibition of pancreatic cancer cell proliferation. (Cheng G, Zielonka J, McAllister D, Tsai S, Dwinell MB, Kalyanaraman B) Br J Cancer 2014 Jul 08;111(1):85-93 PMID: 24867695 PMCID: PMC4090735 05/29/2014       35 Citations
  • High-throughput assays for superoxide and hydrogen peroxide: design of a screening workflow to identify inhibitors of NADPH oxidases. (Zielonka J, Cheng G, Zielonka M, Ganesh T, Sun A, Joseph J, Michalski R, O'Brien WJ, Lambeth JD, Kalyanaraman B) J Biol Chem 2014 Jun 06;289(23):16176-89 PMID: 24764302 PMCID: PMC4047388 04/26/2014       26 Citations
  • Inducible nitric oxide synthase is key to peroxynitrite-mediated, LPS-induced protein radical formation in murine microglial BV2 cells. (Kumar A, Chen SH, Kadiiska MB, Hong JS, Zielonka J, Kalyanaraman B, Mason RP) Free Radic Biol Med 2014 Aug;73:51-9 PMID: 24746617 PMCID: PMC4111989 04/22/2014       40 Citations
  • Detection and identification of oxidants formed during •NO/O2•⁻ reaction: a multi-well plate CW-EPR spectroscopy combined with HPLC analyses. (Koto T, Michalski R, Zielonka J, Joseph J, Kalyanaraman B) Free Radic Res 2014 Apr;48(4):478-86 PMID: 24460755 PMCID: PMC4780754 01/28/2014       4 Citations
  • On the use of fluorescence lifetime imaging and dihydroethidium to detect superoxide in intact animals and ex vivo tissues: a reassessment. (Michalski R, Michalowski B, Sikora A, Zielonka J, Kalyanaraman B) Free Radic Biol Med 2014 Feb;67:278-84 PMID: 24200598 PMCID: PMC4275029 11/10/2013       26 Citations
  • On the use of L-012, a luminol-based chemiluminescent probe, for detecting superoxide and identifying inhibitors of NADPH oxidase: a reevaluation. (Zielonka J, Lambeth JD, Kalyanaraman B) Free Radic Biol Med 2013 Dec;65:1310-1314 PMID: 24080119 PMCID: PMC4274999 10/02/2013       41 Citations
  • Mito-tempol and dexrazoxane exhibit cardioprotective and chemotherapeutic effects through specific protein oxidation and autophagy in a syngeneic breast tumor preclinical model. (Dickey JS, Gonzalez Y, Aryal B, Mog S, Nakamura AJ, Redon CE, Baxa U, Rosen E, Cheng G, Zielonka J, Parekh P, Mason KP, Joseph J, Kalyanaraman B, Bonner W, Herman E, Shacter E, Rao VA) PLoS One 2013;8(8):e70575 PMID: 23940596 PMCID: PMC3734284 08/14/2013       34 Citations
  • Real-time monitoring of reactive oxygen and nitrogen species in a multiwell plate using the diagnostic marker products of specific probes. (Zielonka J, Joseph J, Sikora A, Kalyanaraman B) Methods Enzymol 2013;526:145-57 PMID: 23791099 06/26/2013       14 Citations
  • Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death. (Cheng G, Zielonka J, McAllister DM, Mackinnon AC Jr, Joseph J, Dwinell MB, Kalyanaraman B) BMC Cancer 2013 Jun 13;13:285 PMID: 23764021 PMCID: PMC3686663 06/15/2013       50 Citations
  • Diapocynin prevents early Parkinson's disease symptoms in the leucine-rich repeat kinase 2 (LRRK2R¹⁴⁴¹G) transgenic mouse. (Dranka BP, Gifford A, Ghosh A, Zielonka J, Joseph J, Kanthasamy AG, Kalyanaraman B) Neurosci Lett 2013 Aug 09;549:57-62 PMID: 23721786 PMCID: PMC3729885 06/01/2013       21 Citations
  • HPLC-based monitoring of products formed from hydroethidine-based fluorogenic probes--the ultimate approach for intra- and extracellular superoxide detection. (Kalyanaraman B, Dranka BP, Hardy M, Michalski R, Zielonka J) Biochim Biophys Acta 2014 Feb;1840(2):739-44 PMID: 23668959 PMCID: PMC3858408 05/15/2013       55 Citations
  • Reaction between peroxynitrite and triphenylphosphonium-substituted arylboronic acid isomers: identification of diagnostic marker products and biological implications. (Sikora A, Zielonka J, Adamus J, Debski D, Dybala-Defratyka A, Michalowski B, Joseph J, Hartley RC, Murphy MP, Kalyanaraman B) Chem Res Toxicol 2013 Jun 17;26(6):856-67 PMID: 23611338 PMCID: PMC3700382 04/25/2013       27 Citations
  • Hydropropidine: a novel, cell-impermeant fluorogenic probe for detecting extracellular superoxide. (Michalski R, Zielonka J, Hardy M, Joseph J, Kalyanaraman B) Free Radic Biol Med 2013 Jan;54:135-47 PMID: 23051008 PMCID: PMC3711142 10/12/2012       26 Citations
  • Boronate probes as diagnostic tools for real time monitoring of peroxynitrite and hydroperoxides. (Zielonka J, Sikora A, Hardy M, Joseph J, Dranka BP, Kalyanaraman B) Chem Res Toxicol 2012 Sep 17;25(9):1793-9 PMID: 22731669 PMCID: PMC3501381 06/27/2012       100 Citations
  • Alterations in bioenergetic function induced by Parkinson's disease mimetic compounds: lack of correlation with superoxide generation. (Dranka BP, Zielonka J, Kanthasamy AG, Kalyanaraman B) J Neurochem 2012 Sep;122(5):941-51 PMID: 22708893 PMCID: PMC3423581 06/20/2012       37 Citations
  • Mitochondria-targeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell death. (Cheng G, Zielonka J, Dranka BP, McAllister D, Mackinnon AC Jr, Joseph J, Kalyanaraman B) Cancer Res 2012 May 15;72(10):2634-44 PMID: 22431711 PMCID: PMC3700358 03/21/2012       111 Citations
  • Global profiling of reactive oxygen and nitrogen species in biological systems: high-throughput real-time analyses. (Zielonka J, Zielonka M, Sikora A, Adamus J, Joseph J, Hardy M, Ouari O, Dranka BP, Kalyanaraman B) J Biol Chem 2012 Jan 27;287(5):2984-95 PMID: 22139901 PMCID: PMC3270955 12/06/2011       95 Citations
  • Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy. (Mukhopadhyay P, Horváth B, Zsengellér Z, Zielonka J, Tanchian G, Holovac E, Kechrid M, Patel V, Stillman IE, Parikh SM, Joseph J, Kalyanaraman B, Pacher P) Free Radic Biol Med 2012 Jan 15;52(2):497-506 PMID: 22120494 PMCID: PMC3253235 11/29/2011       108 Citations
  • Mitochondria-targeted nitroxides exacerbate fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells. (Cheng G, Lopez M, Zielonka J, Hauser AD, Joseph J, McAllister D, Rowe JJ, Sugg SL, Williams CL, Kalyanaraman B) Cancer Biol Ther 2011 Oct 15;12(8):707-17 PMID: 21799303 PMCID: PMC3218525 07/30/2011       19 Citations
  • Reaction between peroxynitrite and boronates: EPR spin-trapping, HPLC Analyses, and quantum mechanical study of the free radical pathway. (Sikora A, Zielonka J, Lopez M, Dybala-Defratyka A, Joseph J, Marcinek A, Kalyanaraman B) Chem Res Toxicol 2011 May 16;24(5):687-97 PMID: 21434648 PMCID: PMC3743543 03/26/2011    
  • The iron-chelating drug triapine causes pronounced mitochondrial thiol redox stress. (Myers JM, Antholine WE, Zielonka J, Myers CR) Toxicol Lett 2011 Mar 05;201(2):130-6 PMID: 21195754 01/05/2011       13 Citations
  • The antioxidant transcription factor Nrf2 negatively regulates autophagy and growth arrest induced by the anticancer redox agent mitoquinone. (Rao VA, Klein SR, Bonar SJ, Zielonka J, Mizuno N, Dickey JS, Keller PW, Joseph J, Kalyanaraman B, Shacter E) J Biol Chem 2010 Nov 05;285(45):34447-59 PMID: 20805228 PMCID: PMC2966059 09/02/2010       77 Citations
  • Peroxynitrite is the major species formed from different flux ratios of co-generated nitric oxide and superoxide: direct reaction with boronate-based fluorescent probe. (Zielonka J, Sikora A, Joseph J, Kalyanaraman B) J Biol Chem 2010 May 07;285(19):14210-6 PMID: 20194496 PMCID: PMC2863194 03/03/2010       118 Citations
  • Hydroethidine- and MitoSOX-derived red fluorescence is not a reliable indicator of intracellular superoxide formation: another inconvenient truth. (Zielonka J, Kalyanaraman B) Free Radic Biol Med 2010 Apr 15;48(8):983-1001 PMID: 20116425 PMCID: PMC3587154 02/02/2010       262 Citations
  • Direct oxidation of boronates by peroxynitrite: mechanism and implications in fluorescence imaging of peroxynitrite. (Sikora A, Zielonka J, Lopez M, Joseph J, Kalyanaraman B) Free Radic Biol Med 2009 Nov 15;47(10):1401-7 PMID: 19686842 PMCID: PMC3375817 08/19/2009       158 Citations
  • Doxorubicin inactivates myocardial cytochrome c oxidase in rats: cardioprotection by Mito-Q. (Chandran K, Aggarwal D, Migrino RQ, Joseph J, McAllister D, Konorev EA, Antholine WE, Zielonka J, Srinivasan S, Avadhani NG, Kalyanaraman B) Biophys J 2009 Feb 18;96(4):1388-98 PMID: 19217856 PMCID: PMC2717244 02/17/2009       111 Citations
  • Role of heat shock protein 90 and endothelial nitric oxide synthase during early anesthetic and ischemic preconditioning. (Amour J, Brzezinska AK, Weihrauch D, Billstrom AR, Zielonka J, Krolikowski JG, Bienengraeber MW, Warltier DC, Pratt PF Jr, Kersten JR) Anesthesiology 2009 Feb;110(2):317-25 PMID: 19194158 PMCID: PMC2730207 02/06/2009       45 Citations
  • MyD88-dependent, superoxide-initiated inflammation is necessary for flow-mediated inward remodeling of conduit arteries. (Tang PC, Qin L, Zielonka J, Zhou J, Matte-Martone C, Bergaya S, van Rooijen N, Shlomchik WD, Min W, Sessa WC, Pober JS, Tellides G) J Exp Med 2008 Dec 22;205(13):3159-71 PMID: 19064699 PMCID: PMC2605224 12/10/2008       45 Citations
  • The effect of neighboring methionine residue on tyrosine nitration and oxidation in peptides treated with MPO, H2O2, and NO2(-) or peroxynitrite and bicarbonate: role of intramolecular electron transfer mechanism? (Zhang H, Zielonka J, Sikora A, Joseph J, Xu Y, Kalyanaraman B) Arch Biochem Biophys 2009 Apr 15;484(2):134-45 PMID: 19056332 PMCID: PMC2874256 12/06/2008       17 Citations
  • HPLC study of oxidation products of hydroethidine in chemical and biological systems: ramifications in superoxide measurements. (Zielonka J, Hardy M, Kalyanaraman B) Free Radic Biol Med 2009 Feb 01;46(3):329-38 PMID: 19026738 PMCID: PMC3375818 11/26/2008       96 Citations
  • "ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis"--a critical commentary. (Zielonka J, Kalyanaraman B) Free Radic Biol Med 2008 Nov 01;45(9):1217-9 PMID: 18789385 PMCID: PMC3595710 09/16/2008       28 Citations
  • Cytokines and lipopolysaccharides induce inducible nitric oxide synthase but not enzyme activity in adult rat cardiomyocytes. (Vásquez-Vivar J, Whitsett J, Ionova I, Konorev E, Zielonka J, Kalyanaraman B, Shi Y, Pieper GM) Free Radic Biol Med 2008 Oct 01;45(7):994-1001 PMID: 18634867 PMCID: PMC2578873 07/19/2008       13 Citations
  • Radical scavenging properties of nicotinamide and its metabolites (Sikora A, Szajerski P, Piotrowski L, Zielonka J, Adamus J, Marcinek A, Gebicki J) Radiation Physics and Chemistry 2008;77(3):259-66 03/30/2008    
  • 20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells. (Medhora M, Chen Y, Gruenloh S, Harland D, Bodiga S, Zielonka J, Gebremedhin D, Gao Y, Falck JR, Anjaiah S, Jacobs ER) Am J Physiol Lung Cell Mol Physiol 2008 May;294(5):L902-11 PMID: 18296498 PMCID: PMC2586843 02/26/2008       49 Citations
  • Detection of 2-hydroxyethidium in cellular systems: a unique marker product of superoxide and hydroethidine. (Zielonka J, Vasquez-Vivar J, Kalyanaraman B) Nat Protoc 2008;3(1):8-21 PMID: 18193017 01/15/2008       218 Citations
  • Cytochrome c-mediated oxidation of hydroethidine and mito-hydroethidine in mitochondria: identification of homo- and heterodimers. (Zielonka J, Srinivasan S, Hardy M, Ouari O, Lopez M, Vasquez-Vivar J, Avadhani NG, Kalyanaraman B) Free Radic Biol Med 2008 Mar 01;44(5):835-46 PMID: 18155177 PMCID: PMC2692199 12/25/2007       62 Citations
  • Hydrogen peroxide induces nitric oxide and proteosome activity in endothelial cells: a bell-shaped signaling response. (Thomas S, Kotamraju S, Zielonka J, Harder DR, Kalyanaraman B) Free Radic Biol Med 2007 Apr 01;42(7):1049-61 PMID: 17349932 PMCID: PMC2692187 03/14/2007       55 Citations
  • Pulse radiolysis and steady-state analyses of the reaction between hydroethidine and superoxide and other oxidants. (Zielonka J, Sarna T, Roberts JE, Wishart JF, Kalyanaraman B) Arch Biochem Biophys 2006 Dec 01;456(1):39-47 PMID: 17081495 PMCID: PMC2270254 11/04/2006       46 Citations
  • Radical scavenging and NO-releasing properties of selected beta-adrenoreceptor antagonists. (Szajerski P, Zielonka J, Sikora A, Adamus J, Marcinek A, Gebicki J, Kozlovski VI, Drelicharz L, Chłopicki S) Free Radic Res 2006 Jul;40(7):741-52 PMID: 16984001 09/21/2006       10 Citations
  • The confounding effects of light, sonication, and Mn(III)TBAP on quantitation of superoxide using hydroethidine. (Zielonka J, Vasquez-Vivar J, Kalyanaraman B) Free Radic Biol Med 2006 Oct 01;41(7):1050-7 PMID: 16962930 09/12/2006       40 Citations
  • Anthralin: primary products of its redox reactions. (Czerwinska M, Sikora A, Szajerski P, Zielonka J, Adamus J, Marcinek A, Piech K, Bednarek P, Bally T) J Org Chem 2006 Jul 07;71(14):5312-9 PMID: 16808521 07/01/2006       14 Citations
  • Electrochemical and photochemical reduction of a series of azobenzene dyes in protic and aprotic solvents (Podsiady R, Sokoowska J, Marcinek A, Zielonka J, Chrześcijańska E, Socha A) Coloration Technology 2003;119(5):269-74 06/22/2006    
  • Effect of heparin on viologen-stimulated enzymatic NADH depletion. (Zielonka J, Rybak M, Celińska J, Adamus J, Marcinek A, Gebicki J) Chem Res Toxicol 2006 May;19(5):668-73 PMID: 16696569 05/16/2006       7 Citations
  • Cyclooxygenase 2 rescues LNCaP prostate cancer cells from sanguinarine-induced apoptosis by a mechanism involving inhibition of nitric oxide synthase activity. (Huh J, Liepins A, Zielonka J, Andrekopoulos C, Kalyanaraman B, Sorokin A) Cancer Res 2006 Apr 01;66(7):3726-36 PMID: 16585199 04/06/2006       42 Citations
  • Mechanistic similarities between oxidation of hydroethidine by Fremy's salt and superoxide: stopped-flow optical and EPR studies. (Zielonka J, Zhao H, Xu Y, Kalyanaraman B) Free Radic Biol Med 2005 Oct 01;39(7):853-63 PMID: 16140206 09/06/2005       69 Citations
  • The relationship between the electrochemical and photochemical reduction of some azo dyes derived from 2-aminobenzothiazole (Podsiadły R, Sokołowska J, Marcinek A, Zielonka J, Socha A, Kaźmierska M) Journal of Photochemistry and Photobiology A: Chemistry 2005;171(1):69-76 04/15/2005    
  • Transient species in the stepwise interconversion of NADH and NAD+. (Gebicki J, Marcinek A, Zielonka J) Acc Chem Res 2004 Jun;37(6):379-86 PMID: 15196047 06/16/2004       91 Citations
  • Color changes accompanying one-electron reduction and oxidation of the azo dyes (Zielonka J, Podsiad R, Czerwińska M, Sikora A, Sokołowska J, Marcinek A) Journal of Photochemistry and Photobiology A: Chemistry 2004;163(3):373-9 05/21/2004    
  • 1-Methyl-3-nitropyridine: an efficient oxidant of NADH in non-enzymatic and enzyme-mediated processes. (Wieczorkowska M, Zielonka J, Celińska J, Adamus J, Ciesielska E, Marcinek A, Szmigiero L, Gebicki J) Free Radic Res 2003 Nov;37(11):1157-62 PMID: 14703727 01/06/2004       6 Citations
  • Direct Observation of NADH Radical Cation Generated in Reactions with One-Electron Oxidants (Zielonka J, Marcinek A, Adamus J, Gȩbicki J) Journal of Physical Chemistry A 2003;107(46):9860-4 10/25/2003    
  • Radical scavenging properties of genistein. (Zielonka J, Gebicki J, Grynkiewicz G) Free Radic Biol Med 2003 Oct 15;35(8):958-65 PMID: 14556860 10/15/2003       81 Citations
  • In search for new drugs: From basic research to market product (Gȩbicki J, Adamus J, Marcinek A, Zielonka J, Sysa-Jȩdrzejowska A, Woźniacka A, Denys A, Ciebiada I, Szmigiero L, Ciesielska E, Wieczorkowska M.) Przemysl Chemiczny 2003;82(8-9):507-10 09/30/2003    
  • 1-Methylnicotinamide: a potent anti-inflammatory agent of vitamin origin. (Gebicki J, Sysa-Jedrzejowska A, Adamus J, Woźniacka A, Rybak M, Zielonka J) Pol J Pharmacol 2003 Jan-Feb;55(1):109-12 PMID: 12856834 07/15/2003       56 Citations
  • Benzopinacol Radical Cation (Rogowski J, Zielonka J, Marcinek A, Gȩbicki J, Bednarek P) Journal of Physical Chemistry A 2003;107(6):810-4 01/17/2003    
  • Ionic Liquids:  Novel Media for Characterization of Radical Ions (Marcinek A, Zielonka J, Gȩbicki J, Gordon CM, Dunkin IR) Journal of Physical Chemistry A 2001;105(40):9305-9 09/15/2001    
  • Direct Characterization of Radical Species Generated on One-Electron Oxidation of 3,6-Diamino-10-methylacridan (Marcinek A, Zielonka J, Adamus J, Gȩbicki J, Platz MS) The Journal of Physical Chemistry A 2001;105(5):875-9. 01/10/2001    
  • Last update: 11/28/2018
    jenkins-FCD Prod-299 9ef562391eceb2b8f95265c767fbba1ce5a52fd6