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Michael E. Widlansky MD

Michael E. Widlansky MD

Associate Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Cardiology
Program: Administration

Member of the Cancer Center
Member of the Cardiovascular Center

Research Experience

  • Aging
  • Coronary Artery Disease
  • Diabetes Complications
  • Diabetes Mellitus, Type 2
  • Endothelium-Dependent Relaxing Factors
  • Exercise
  • Hypertension
  • Hypoglycemia
  • Nitric Oxide
  • endothelial function
  • Clinical Expertise

  • Coronary Artery Disease
  • Echocardiography
  • Methodologies and Techniques

  • Microbubbles
  • Microscopy, Video
  • Plethysmography
  • Ultrasonography
  • arterial tonometry
  • digital pulse amplitude tonometry
  • flow mediate dilation
  • Leadership Positions

  • Member, Continuing Medical Education Committee
  • Associate Fellowship Director, Cardiovascular Diseases
  • Research Director, Division of Cardiovascular Medicine
  • Chair, Human Research Affairs Committee
  • Member, Reserach Affairs Committee
  • MCW Program / Core Facilities

  • Human Vascular Translational Reserach Core
  • Publications

  • Impact of DPP-4 inhibition on acute and chronic endothelial function in humans with type 2 diabetes on background metformin therapy. (Widlansky ME, Puppala VK, Suboc TM, Malik M, Branum A, Signorelli K, Wang J, Ying R, Tanner MJ, Tyagi S) Vasc Med 2017 Jan 01:1358863X16681486 PMID: 28145158 02/02/2017
  • Dynamin-related protein 1 mediates low glucose-induced endothelial dysfunction in human arterioles. (Tanner MJ, Wang J, Ying R, Suboc TB, Malik M, Couillard A, Branum A, Puppala V, Widlansky ME) Am J Physiol Heart Circ Physiol 2017 Mar 01;312(3):H515-H527 PMID: 27923790 12/08/2016
  • Pacemaker Quantified Physical Activity Predicts All-Cause Mortality. (Tyagi S, Curley M, Berger M, Fox J, Strath SJ, Rubenstein J, Roth J, Widlansky ME) J Am Coll Cardiol 2015 Aug 11;66(6):754-5 PMID: 26248996 08/08/2015
  • Associations of Reducing Sedentary Time With Vascular Function and Insulin Sensitivity in Older Sedentary Adults. (Suboc TB, Knabel D, Strath SJ, Dharmashankar K, Coulliard A, Malik M, Haak K, Widlansky ME) Am J Hypertens 2016 Jan;29(1):46-53 PMID: 25987647 05/20/2015
  • Mineralocorticoid exposure and receptor activity modulate microvascular endothelial function in African Americans with and without hypertension. (Mohandas A, Suboc TB, Wang J, Ying R, Tarima S, Dharmashankar K, Malik M, Widlansky ME) Vasc Med 2015 Oct;20(5):401-8 PMID: 25978968 05/17/2015
  • Firefighting: can our arteries take the heat? (Malik M, Widlansky ME) Vasc Med 2015 Jun;20(3):219-21 PMID: 25939656 05/06/2015
  • Cardiovascular magnetic resonance imaging-based computational fluid dynamics/fluid-structure interaction pilot study to detect early vascular changes in pediatric patients with type 1 diabetes. (Samyn MM, Dholakia R, Wang H, Co-Vu J, Yan K, Widlansky ME, LaDisa JF, Simpson P, Alemzadeh R) Pediatr Cardiol 2015 Apr;36(4):851-61 PMID: 25577225 01/13/2015
  • The Impact of Moderate Intensity Physical Activity on Cardiac Structure and Performance in Older Sedentary Adults. (Suboc TB, Strath SJ, Dharmashankar K, Harmann L, Couillard A, Malik M, Haak K, Knabel D, Widlansky ME) Int J Cardiol Heart Vessels 2014 Sep 01;4:19-24 PMID: 25530947 PMCID: PMC4269267 12/23/2014
  • The vascular renin-angiotensin system contributes to blunted vasodilation induced by transient high pressure in human adipose microvessels. (Durand MJ, Phillips SA, Widlansky ME, Otterson MF, Gutterman DD) Am J Physiol Heart Circ Physiol 2014 Jul 01;307(1):H25-32 PMID: 24778165 PMCID: PMC4080172 04/30/2014
  • Relative importance of step count, intensity, and duration on physical activity's impact on vascular structure and function in previously sedentary older adults. (Suboc TB, Strath SJ, Dharmashankar K, Coulliard A, Miller N, Wang J, Tanner MJ, Widlansky ME) J Am Heart Assoc 2014 Feb 26;3(1):e000702 PMID: 24572255 PMCID: PMC3959701 02/28/2014
  • Moderate Obesity and Endothelial Dysfunction in Humans: Influence of Gender and Systemic Inflammation. (Suboc TM, Dharmashankar K, Wang J, Ying R, Couillard A, Tanner MJ, Widlansky ME) Physiol Rep 2013 Aug 01;1(3) PMID: 24187612 PMCID: PMC3811111 11/05/2013
  • Human endothelial dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recycling. (Whitsett J, Rangel Filho A, Sethumadhavan S, Celinska J, Widlansky M, Vasquez-Vivar J) Free Radic Biol Med 2013 Oct;63:143-50 PMID: 23707606 PMCID: PMC3748942 05/28/2013
  • Adverse alterations in mitochondrial function contribute to type 2 diabetes mellitus-related endothelial dysfunction in humans. (Kizhakekuttu TJ, Wang J, Dharmashankar K, Ying R, Gutterman DD, Vita JA, Widlansky ME) Arterioscler Thromb Vasc Biol 2012 Oct;32(10):2531-9 PMID: 22879582 PMCID: PMC3570053 08/11/2012
  • Relations of exercise blood pressure response to cardiovascular risk factors and vascular function in the Framingham Heart Study. (Thanassoulis G, Lyass A, Benjamin EJ, Larson MG, Vita JA, Levy D, Hamburg NM, Widlansky ME, O'Donnell CJ, Mitchell GF, Vasan RS) Circulation 2012 Jun 12;125(23):2836-43 PMID: 22572915 PMCID: PMC3636551 05/11/2012
  • Effect of sulfasalazine on inflammation and endothelial function in patients with established coronary artery disease. (Tabit CE, Holbrook M, Shenouda SM, Dohadwala MM, Widlansky ME, Frame AA, Kim BH, Duess MA, Kluge MA, Levit A, Keaney JF Jr, Vita JA, Hamburg NM) Vasc Med 2012 Apr;17(2):101-7 PMID: 22496207 PMCID: PMC3632403 04/13/2012
  • Nitric oxide synthase-dependent vasodilation of human subcutaneous arterioles correlates with noninvasive measurements of endothelial function. (Dharmashankar K, Welsh A, Wang J, Kizhakekuttu TJ, Ying R, Gutterman DD, Widlansky ME) Am J Hypertens 2012 May;25(5):528-34 PMID: 22337207 PMCID: PMC3328603 02/18/2012
  • Acute exposure to low glucose rapidly induces endothelial dysfunction and mitochondrial oxidative stress: role for AMP kinase. (Wang J, Alexanian A, Ying R, Kizhakekuttu TJ, Dharmashankar K, Vasquez-Vivar J, Gutterman DD, Widlansky ME) Arterioscler Thromb Vasc Biol 2012 Mar;32(3):712-20 PMID: 22207730 PMCID: PMC3319449 12/31/2011
  • Arteriolar function in visceral adipose tissue is impaired in human obesity. (Farb MG, Ganley-Leal L, Mott M, Liang Y, Ercan B, Widlansky ME, Bigornia SJ, Fiscale AJ, Apovian CM, Carmine B, Hess DT, Vita JA, Gokce N) Arterioscler Thromb Vasc Biol 2012 Feb;32(2):467-73 PMID: 22095978 PMCID: PMC3262114 11/19/2011
  • Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus. (Shenouda SM, Widlansky ME, Chen K, Xu G, Holbrook M, Tabit CE, Hamburg NM, Frame AA, Caiano TL, Kluge MA, Duess MA, Levit A, Kim B, Hartman ML, Joseph L, Shirihai OS, Vita JA) Circulation 2011 Jul 26;124(4):444-53 PMID: 21747057 PMCID: PMC3149100 07/13/2011
  • Folic acid supplementation improves vascular function in professional dancers with endothelial dysfunction. (Hoch AZ, Papanek P, Szabo A, Widlansky ME, Gutterman DD) PM R 2011 Nov;3(11):1005-12 PMID: 21715240 PMCID: PMC3328806 07/01/2011
  • Association between the female athlete triad and endothelial dysfunction in dancers. (Hoch AZ, Papanek P, Szabo A, Widlansky ME, Schimke JE, Gutterman DD) Clin J Sport Med 2011 Mar;21(2):119-25 PMID: 21358502 PMCID: PMC3570811 03/02/2011
  • Impaired endothelial function in preadolescent children with type 1 diabetes. (Babar GS, Zidan H, Widlansky ME, Das E, Hoffmann RG, Daoud M, Alemzadeh R) Diabetes Care 2011 Mar;34(3):681-5 PMID: 21289230 PMCID: PMC3041207 02/04/2011
  • Reply to "Letter to the editor: 'Assessment of flow-mediated dilation in humans: a methodological and physiological guideline'". (Thijssen DH et al.) Am J Physiol Heart Circ Physiol 2011 Feb;300(2):H713 PMID: 21282475 02/02/2011
  • Regulation of endothelial function by mitochondrial reactive oxygen species. (Widlansky ME, Gutterman DD) Antioxid Redox Signal 2011 Sep 15;15(6):1517-30 PMID: 21194353 PMCID: PMC3151425 01/05/2011
  • Assessment of flow-mediated dilation in humans: a methodological and physiological guideline. (Thijssen DH, Black MA, Pyke KE, Padilla J, Atkinson G, Harris RA, Parker B, Widlansky ME, Tschakovsky ME, Green DJ) Am J Physiol Heart Circ Physiol 2011 Jan;300(1):H2-12 PMID: 20952670 PMCID: PMC3023245 10/19/2010
  • Vascular endothelial function and hypertension: insights and directions. (Dharmashankar K, Widlansky ME) Curr Hypertens Rep 2010 Dec;12(6):448-55 PMID: 20857237 PMCID: PMC2982873 09/22/2010
  • Measuring FMD in the brachial artery: how important is QRS gating? (Kizhakekuttu TJ, Gutterman DD, Phillips SA, Jurva JW, Arthur EI, Das E, Widlansky ME) J Appl Physiol (1985) 2010 Oct;109(4):959-65 PMID: 20671033 PMCID: PMC2963331 07/31/2010
  • Altered mitochondrial membrane potential, mass, and morphology in the mononuclear cells of humans with type 2 diabetes. (Widlansky ME, Wang J, Shenouda SM, Hagen TM, Smith AR, Kizhakekuttu TJ, Kluge MA, Weihrauch D, Gutterman DD, Vita JA) Transl Res 2010 Jul;156(1):15-25 PMID: 20621033 PMCID: PMC2904361 07/14/2010
  • The danger of sedenterism: endothelium at risk. (Widlansky ME) Am J Physiol Heart Circ Physiol 2010 Aug;299(2):H243-4 PMID: 20511408 06/01/2010
  • Natural antioxidants and hypertension: promise and challenges. (Kizhakekuttu TJ, Widlansky ME) Cardiovasc Ther 2010 Aug;28(4):e20-32 PMID: 20370791 PMCID: PMC2905473 04/08/2010
  • Parstatin: a cryptic peptide involved in cardioprotection after ischaemia and reperfusion injury. (Strande JL, Widlansky ME, Tsopanoglou NE, Su J, Wang J, Hsu A, Routhu KV, Baker JE) Cardiovasc Res 2009 Jul 15;83(2):325-34 PMID: 19380418 PMCID: PMC2701720 04/22/2009
  • Lifestyle choices and endothelial function: risk and relevance. (Wang J, Widlansky ME) Curr Vasc Pharmacol 2009 Apr;7(2):209-24 PMID: 19356004 04/10/2009
  • Shear stress and flow-mediated dilation: all shear responses are not created equally. (Widlansky ME) Am J Physiol Heart Circ Physiol 2009 Jan;296(1):H31-2 PMID: 19028789 11/26/2008
  • Metabolic syndrome, insulin resistance, and brachial artery vasodilator function in Framingham Offspring participants without clinical evidence of cardiovascular disease. (Hamburg NM, Larson MG, Vita JA, Vasan RS, Keyes MJ, Widlansky ME, Fox CS, Mitchell GF, Levy D, Meigs JB, Benjamin EJ) Am J Cardiol 2008 Jan 01;101(1):82-8 PMID: 18157970 PMCID: PMC2214853 12/26/2007
  • Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers. (Hamburg NM, McMackin CJ, Huang AL, Shenouda SM, Widlansky ME, Schulz E, Gokce N, Ruderman NB, Keaney JF Jr, Vita JA) Arterioscler Thromb Vasc Biol 2007 Dec;27(12):2650-6 PMID: 17932315 PMCID: PMC2596308 10/13/2007
  • Relation of season and temperature to endothelium-dependent flow-mediated vasodilation in subjects without clinical evidence of cardiovascular disease (from the Framingham Heart Study). (Widlansky ME, Vita JA, Keyes MJ, Larson MG, Hamburg NM, Levy D, Mitchell GF, Osypiuk EW, Vasan RS, Benjamin EJ) Am J Cardiol 2007 Aug 01;100(3):518-23 PMID: 17659939 PMCID: PMC1994775 07/31/2007
  • Acute EGCG supplementation reverses endothelial dysfunction in patients with coronary artery disease. (Widlansky ME, Hamburg NM, Anter E, Holbrook M, Kahn DF, Elliott JG, Keaney JF Jr, Vita JA) J Am Coll Nutr 2007 Apr;26(2):95-102 PMID: 17536120 PMCID: PMC3773609 05/31/2007
  • Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease. (McMackin CJ, Widlansky ME, Hamburg NM, Huang AL, Weller S, Holbrook M, Gokce N, Hagen TM, Keaney JF Jr, Vita JA) J Clin Hypertens (Greenwich) 2007 Apr;9(4):249-55 PMID: 17396066 PMCID: PMC2734271 03/31/2007
  • Effects of black tea consumption on plasma catechins and markers of oxidative stress and inflammation in patients with coronary artery disease. (Widlansky ME, Duffy SJ, Hamburg NM, Gokce N, Warden BA, Wiseman S, Keaney JF Jr, Frei B, Vita JA) Free Radic Biol Med 2005 Feb 15;38(4):499-506 PMID: 15649652 01/15/2005
  • Body mass index and total and cardiovascular mortality in men with a history of cardiovascular disease. (Widlansky ME, Sesso HD, Rexrode KM, Manson JE, Gaziano JM) Arch Intern Med 2004 Nov 22;164(21):2326-32 PMID: 15557411 11/24/2004
  • Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. (Smith AR, Shenvi SV, Widlansky M, Suh JH, Hagen TM) Curr Med Chem 2004 May;11(9):1135-46 PMID: 15134511 05/12/2004
  • Coronary endothelial dysfunction is not rapidly reversible with ascorbic acid. (Widlansky ME, Biegelsen ES, Hamburg NM, Duffy SJ, Keaney JF Jr, Vita JA) Free Radic Biol Med 2004 Jan 01;36(1):123-30 PMID: 14732296 01/21/2004
  • The clinical implications of endothelial dysfunction. (Widlansky ME, Gokce N, Keaney JF Jr, Vita JA) J Am Coll Cardiol 2003 Oct 01;42(7):1149-60 PMID: 14522472 10/03/2003
  • Short- and long-term COX-2 inhibition reverses endothelial dysfunction in patients with hypertension. (Widlansky ME, Price DT, Gokce N, Eberhardt RT, Duffy SJ, Holbrook M, Maxwell C, Palmisano J, Keaney JF Jr, Morrow JD, Vita JA) Hypertension 2003 Sep;42(3):310-5 PMID: 12874094 07/23/2003
  • Last update: 03/21/2017
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