Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Nikki Johnston PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Otolaryngology
Program: Adult

Member of the Cancer Center


  • Local Synthesis of Pepsin in Barrett's Esophagus and the Role of Pepsin in Esophageal Adenocarcinoma. (Samuels T, Hoekzema C, Gould J, Goldblatt M, Frelich M, Bosler M, Lee SH, Johnston N) Ann Otol Rhinol Laryngol 2015 Jun 15: PMID: 26077392
  • Association between tracheal pepsin, a reliable marker of gastric aspiration, and head of bed elevation among ventilated neonates. (Garland JS, Alex CP, Johnston N, Yan JC, Werlin SL) J Neonatal Perinatal Med 2014 Jan 1;7(3):185-92 PMID: 25318633
  • Establishment of an immortalized laryngeal posterior commissure cell line as a tool for reflux research. (Lee SH, Samuels T, Bock JM, Blumin JH, Johnston N) Laryngoscope 2015 Feb;125(2):E73-7 PMID: 25272366
  • Upper esophageal and pharyngeal cancers. (Bock JM, Howell AB, Johnston N, Kresty LA, Lew D) Ann N Y Acad Sci 2014 Sep;1325:49-56 PMID: 25266014
  • Differential response of gel-forming mucins to pathogenic middle ear bacteria. (Kerschner JE, Hong W, Khampang P, Johnston N) Int J Pediatr Otorhinolaryngol 2014 Aug;78(8):1368-73 PMID: 24958163 PMCID: PMC4104932
  • Chronic pepsin exposure promotes anchorage-independent growth and migration of a hypopharyngeal squamous cell line. (Kelly EA, Samuels TL, Johnston N) Otolaryngol Head Neck Surg 2014 Apr;150(4):618-24 PMID: 24376122 PMCID: PMC4423599
  • Curcumin and anthocyanin inhibit pepsin-mediated cell damage and carcinogenic changes in airway epithelial cells. (Samuels TL, Pearson AC, Wells CW, Stoner GD, Johnston N) Ann Otol Rhinol Laryngol 2013 Oct;122(10):632-41 PMID: 24294686
  • The utility of endoscopy and multichannel intraluminal impedance testing in children with cough and wheezing. (Rosen R, Amirault J, Johnston N, Haver K, Khatwa U, Rubinstein E, Nurko S) Pediatr Pulmonol 2014 Nov;49(11):1090-6 PMID: 24178927
  • Laryngopharyngeal reflux and GERD. (Johnston N, Dettmar PW, Strugala V, Allen JE, Chan WW) Ann N Y Acad Sci 2013 Oct;1300:71-9 PMID: 24117635
  • Prevalence of pediatric aspiration-associated extraesophageal reflux disease. (Kelly EA, Parakininkas DE, Werlin SL, Southern JF, Johnston N, Kerschner JE) JAMA Otolaryngol Head Neck Surg 2013 Oct;139(10):996-1001 PMID: 23989194
  • Extra-esophageal reflux, NOSE score, and sleep quality in an adult clinic population. (Laohasiriwong S, Johnston N, Woodson BT) Laryngoscope 2013 Dec;123(12):3233-8 PMID: 23754257
  • Potential benefits of pH 8.8 alkaline drinking water as an adjunct in the treatment of reflux disease. (Koufman JA, Johnston N) Ann Otol Rhinol Laryngol 2012 Jul;121(7):431-4 PMID: 22844861
  • Reproducibility of Salivary Pepsin: Clinic versus Home. (Laohasiriwong S, Johnston N, Woodson BT) Otolaryngol Head Neck Surg 2012 Aug;147(2 suppl):P195 PMID: 25718691
  • Extra-Esophageal Reflux (EER) and Sleep Disorders. (Laohasiriwong S, Woodson BT, Johnston N) Otolaryngol Head Neck Surg 2012 Aug;147(2 suppl):P120 PMID: 25718434
  • Pepsin promotes proliferation of laryngeal and pharyngeal epithelial cells. (Johnston N, Yan JC, Hoekzema CR, Samuels TL, Stoner GD, Blumin JH, Bock JM) Laryngoscope 2012 Jun;122(6):1317-25 PMID: 22570308 PMCID: PMC3816638
  • The role of extraesophageal reflux in medically and surgically refractory rhinosinusitis. (Loehrl TA, Samuels TL, Poetker DM, Toohill RJ, Blumin JH, Johnston N) Laryngoscope 2012 Jul;122(7):1425-30 PMID: 22539181
  • Reflux aspiration in children with neurodisability--a significant problem, but can we measure it? (Trinick R, Johnston N, Dalzell AM, McNamara PS) J Pediatr Surg 2012 Feb;47(2):291-8 PMID: 22325378
  • The presence of pepsin in the lung and its relationship to pathologic gastro-esophageal reflux. (Rosen R, Johnston N, Hart K, Khatwa U, Nurko S) Neurogastroenterol Motil 2012 Feb;24(2):129-33, e84-5 PMID: 22141343 PMCID: PMC3307906
  • Hoarseness and chronic cough: would you suspect reflux? (Sana S, Sana M, Johnston N, Mittal SK) J Fam Pract 2011 Aug;60(8):458-62 PMID: 21814640
  • Higher rate of bronchoalveolar lavage culture positivity in children with nonacid reflux and respiratory disorders. (Rosen R, Johnston N, Hart K, Khatwa U, Katz E, Nurko S) J Pediatr 2011 Sep;159(3):504-6 PMID: 21777922 PMCID: PMC3157561
  • Pepsin detection in patients with laryngopharyngeal reflux before and after fundoplication. (Wassenaar E, Johnston N, Merati A, Montenovo M, Petersen R, Tatum R, Pellegrini C, Oelschlager B) Surg Endosc 2011 Dec;25(12):3870-6 PMID: 21695583
  • Evidence of extraesophageal reflux in idiopathic subglottic stenosis. (Blumin JH, Johnston N) Laryngoscope 2011 Jun;121(6):1266-73 PMID: 21557240
  • Review article: reflux and its consequences--the laryngeal, pulmonary and oesophageal manifestations. Conference held in conjunction with the 9th International Symposium on Human Pepsin (ISHP) Kingston-upon-Hull, UK, 21-23 April 2010. (Pearson JP, Parikh S, Orlando RC, Johnston N, Allen J, Tinling SP, Johnston N, Belafsky P, Arevalo LF, Sharma N, Castell DO, Fox M, Harding SM, Morice AH, Watson MG, Shields MD, Bateman N, McCallion WA, van Wijk MP, Wenzl TG, Karkos PD, Belafsky PC) Aliment Pharmacol Ther 2011 Apr;33 Suppl 1:1-71 PMID: 21366630
  • Analysis of pepsin in tracheoesophageal puncture sites. (Bock JM, Brawley MK, Johnston N, Samuels T, Massey BL, Campbell BH, Toohill RJ, Blumin JH) Ann Otol Rhinol Laryngol 2010 Dec;119(12):799-805 PMID: 21250551
  • Rationale for targeting pepsin in the treatment of reflux disease. (Johnston N, Wells CW, Samuels TL, Blumin JH) Ann Otol Rhinol Laryngol 2010 Aug;119(8):547-58 PMID: 20860281
  • Pepsin as a marker of extraesophageal reflux. (Samuels TL, Johnston N) Ann Otol Rhinol Laryngol 2010 Mar;119(3):203-8 PMID: 20392035
  • Pepsin as a causal agent of inflammation during nonacidic reflux. (Samuels TL, Johnston N) Otolaryngol Head Neck Surg 2009 Nov;141(5):559-63 PMID: 19861190
  • Pepsin in nonacidic refluxate can damage hypopharyngeal epithelial cells. (Johnston N, Wells CW, Samuels TL, Blumin JH) Ann Otol Rhinol Laryngol 2009 Sep;118(9):677-85 PMID: 19810610
  • Immunologic response of the laryngeal mucosa to extraesophageal reflux. (Birchall MA, Bailey M, Gutowska-Owsiak D, Johnston N, Inman CF, Stokes CR, Postma G, Pazmany L, Koufman JA, Phillips A, Rees LE) Ann Otol Rhinol Laryngol 2008 Dec;117(12):891-5 PMID: 19140534
  • Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux. (Samuels TL, Handler E, Syring ML, Pajewski NM, Blumin JH, Kerschner JE, Johnston N) Ann Otol Rhinol Laryngol 2008 Sep;117(9):688-95 PMID: 18834073
  • The mucosal immune response to laryngopharyngeal reflux. (Rees LE, Pazmany L, Gutowska-Owsiak D, Inman CF, Phillips A, Stokes CR, Johnston N, Koufman JA, Postma G, Bailey M, Birchall MA) Am J Respir Crit Care Med 2008 Jun 1;177(11):1187-93 PMID: 18323539 PMCID: PMC2643204
  • Receptor-mediated uptake of pepsin by laryngeal epithelial cells. (Johnston N, Wells CW, Blumin JH, Toohill RJ, Merati AL) Ann Otol Rhinol Laryngol 2007 Dec;116(12):934-8 PMID: 18217514
  • Role of extra-esophageal reflux in chronic otitis media with effusion. (Crapko M, Kerschner JE, Syring M, Johnston N) Laryngoscope 2007 Aug;117(8):1419-23 PMID: 17585281
  • Activity/stability of human pepsin: implications for reflux attributed laryngeal disease. (Johnston N, Dettmar PW, Bishwokarma B, Lively MO, Koufman JA) Laryngoscope 2007 Jun;117(6):1036-9 PMID: 17417109
  • Effect of pepsin on laryngeal stress protein (Sep70, Sep53, and Hsp70) response: role in laryngopharyngeal reflux disease. (Johnston N, Dettmar PW, Lively MO, Postma GN, Belafsky PC, Birchall M, Koufman JA) Ann Otol Rhinol Laryngol 2006 Jan;115(1):47-58 PMID: 16466100
  • Laryngeal epithelial defenses against laryngopharyngeal reflux: investigations of E-cadherin, carbonic anhydrase isoenzyme III, and pepsin. (Gill GA, Johnston N, Buda A, Pignatelli M, Pearson J, Dettmar PW, Koufman J) Ann Otol Rhinol Laryngol 2005 Dec;114(12):913-21 PMID: 16425556
  • Sensitive pepsin immunoassay for detection of laryngopharyngeal reflux. (Knight J, Lively MO, Johnston N, Dettmar PW, Koufman JA) Laryngoscope 2005 Aug;115(8):1473-8 PMID: 16094128
  • Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease. (Johnston N, Knight J, Dettmar PW, Lively MO, Koufman J) Laryngoscope 2004 Dec;114(12):2129-34 PMID: 15564833
  • Cell biology of laryngeal epithelial defenses in health and disease: further studies. (Johnston N, Bulmer D, Gill GA, Panetti M, Ross PE, Pearson JP, Pignatelli M, Axford SE, Dettmar PW, Koufman JA) Ann Otol Rhinol Laryngol 2003 Jun;112(6):481-91 PMID: 12834114
  • Cell biology of laryngeal epithelial defenses in health and disease: preliminary studies. (Axford SE, Sharp N, Ross PE, Pearson JP, Dettmar PW, Panetti M, Koufman JA) Ann Otol Rhinol Laryngol 2001 Dec;110(12):1099-108 PMID: 11768697
  • Last update: 06/18/2015