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Paul Joseph Pearson MD, PhD

Paul Joseph Pearson MD, PhD

Chief, Professor

Institution: Medical College of Wisconsin
Department: Surgery
Division: Cardiothoracic
Program: Cardiothoracic Surgery

Member of the Cardiovascular Center


  • CABG for Multivessel CAD. Recent studies show that CABG is still preferred over PCI for most patients. (Chatterjee S, Alexander JC, Pearson PJ) Cardiac Interventions Today Jan/Feb 38-42 09/05/2017    
  • Techniques for percutaneous left ventricular access. (Guerrero M, Pursnani A, Salinger M, Levisay J, Pearson PJ, Feldman T) Cardiac Interventions Today July/Aug:48-52 09/05/2017    
  • Who should undergo TAVR? The role of Transcatheter valve replacement as a new paradigm for treating aortic stenosis. (Pearson PJ.) Cardiac Interventions Today Sept/Oct: 1-3 09/05/2017    
  • Advantages to Miniaturized Cardiopulmonary Bypass for Adult Cardiac Surgery. (Chatterjee S, Hoff WJ, Pearson PJ) J Clinical & Experimental Cardiology S:7 09/05/2017    
  • Interventional Management in Patients with Paravalvular Leaks. (Feldman TF, Salinger M, Guerrero M, Pearson PJ.) 08/31/2017    
  • Valve Repair and Choice of Valves. (Yusif S, Cairns J, Camm AJ, Fallen EL, Gersh BJ.) British Medical Journal Books, London 08/31/2017    
  • Arterial Cutaneous Femoral Fistulous Tract Closure Using Surgiflo Hemostatic Matrix: A Novel Adjunct for Post-TAVR Access-Site Management. (Gajo E, Iftikhar O, Pearson PJ, Feldman T, Guerrero M, Levisay J, Salinger MH) J Invasive Cardiol 2017 Aug;29(8):277-279 PMID: 28756421 08/02/2017    
  • Transseptal transcatheter mitral valve-in-valve: A step by step guide from preprocedural planning to postprocedural care. (Guerrero M, Salinger M, Pursnani A, Pearson P, Lampert M, Levisay J, Russell H, Feldman T) Catheter Cardiovasc Interv 2018 Sep 01;92(3):E185-E196 PMID: 28557344 05/31/2017       3 Citations
  • Point/Counterpoint: Does the United States have enough TAVR centers? TAVAR has matured and is ready for many more sites. (Paul J. Pearson, MD, PhD; and D. Craig Miller, MD) Cardiac Interventions Today 11(3), May/June. 29-36, 2017. 05/01/2017    
  • Transcatheter Mitral Valve Replacement for Patients With Symptomatic Mitral Regurgitation: A Global Feasibility Trial. (Muller DWM, Farivar RS, Jansz P, Bae R, Walters D, Clarke A, Grayburn PA, Stoler RC, Dahle G, Rein KA, Shaw M, Scalia GM, Guerrero M, Pearson P, Kapadia S, Gillinov M, Pichard A, Corso P, Popma J, Chuang M, Blanke P, Leipsic J, Sorajja P, Tendyne Global Feasibility Trial Investigators) J Am Coll Cardiol 2017 Jan 31;69(4):381-391 PMID: 28040318 01/04/2017       82 Citations
  • Everolimus-Eluting Stents or Bypass Surgery for Left Main Coronary Artery Disease. (Stone GW, Sabik JF, Serruys PW, Simonton CA, Généreux P, Puskas J, Kandzari DE, Morice MC, Lembo N, Brown WM 3rd, Taggart DP, Banning A, Merkely B, Horkay F, Boonstra PW, van Boven AJ, Ungi I, Bogáts G, Mansour S, Noiseux N, Sabaté M, Pomar J, Hickey M, Gershlick A, Buszman P, Bochenek A, Schampaert E, Pagé P, Dressler O, Kosmidou I, Mehran R, Pocock SJ, Kappetein AP, EXCEL Trial Investigators) N Engl J Med 2016 12 08;375(23):2223-2235 PMID: 27797291 11/01/2016       273 Citations
  • Left atrial volumetric assessment using a novel automated framework for 3D echocardiography: a multi-centre analysis. (Almeida N, Papachristidis A, Pearson P, Sarvari SI, Engvall J, Edvardsen T, Monaghan M, Gérard O, Samset E, D'hooge J) Eur Heart J Cardiovasc Imaging 2017 Sep 01;18(9):1008-1015 PMID: 27550659 08/24/2016       2 Citations
  • Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients. (Leon MB, Smith CR, Mack MJ, Makkar RR, Svensson LG, Kodali SK, Thourani VH, Tuzcu EM, Miller DC, Herrmann HC, Doshi D, Cohen DJ, Pichard AD, Kapadia S, Dewey T, Babaliaros V, Szeto WY, Williams MR, Kereiakes D, Zajarias A, Greason KL, Whisenant BK, Hodson RW, Moses JW, Trento A, Brown DL, Fearon WF, Pibarot P, Hahn RT, Jaber WA, Anderson WN, Alu MC, Webb JG, PARTNER 2 Investigators) N Engl J Med 2016 04 28;374(17):1609-20 PMID: 27040324 04/05/2016       1156 Citations
  • Percutaneous closure of post TAVR LV apical pseudoaneurysm. (Feldman T, Pearson P, Smart SS) Catheter Cardiovasc Interv 2016 Sep;88(3):479-85 PMID: 26268615 08/14/2015       5 Citations
  • The potential impact of new national guidance on primary prevention of cardiovascular disease in people living with HIV. (Ahmed N, Bradley S, Pearson P, Edwards S, Waters L) J Int AIDS Soc 2014;17(4 Suppl 3):19713 PMID: 25397460 PMCID: PMC4225371 11/15/2014    
  • Isolated mitral valve surgery risk in 77,836 patients from the Society of Thoracic Surgeons database. (Chatterjee S, Rankin JS, Gammie JS, Sheng S, O'Brien SM, Brennan JM, Alexander JC, Thourani VH, Pearson PJ, Suri RM) Ann Thorac Surg 2013 Nov;96(5):1587-94; discussion 1594-5 PMID: 24011622 09/10/2013       34 Citations
  • 4-year results of a randomized controlled trial of percutaneous repair versus surgery for mitral regurgitation. (Mauri L, Foster E, Glower DD, Apruzzese P, Massaro JM, Herrmann HC, Hermiller J, Gray W, Wang A, Pedersen WR, Bajwa T, Lasala J, Low R, Grayburn P, Feldman T, EVEREST II Investigators) J Am Coll Cardiol 2013 Jul 23;62(4):317-28 PMID: 23665364 05/15/2013       246 Citations
  • Simple technique to verify CO(2) diffusion with the CarbonAid™ device. (Chatterjee S, Greenberg SB, Brown J, Murphy GS, Pearson PJ, Alexander JC) Heart Surg Forum 2012 Aug;15(4):E212-4 PMID: 22917826 08/25/2012    
  • Successful transcatheter aortic valve implantation (TAVI) is associated with transient left ventricular dysfunction. (Dworakowski R, Wendler O, Bhan A, Smith L, Pearson P, Alcock E, Rajagopal K, Brickham B, Dew T, Byrne J, Monaghan MJ, Sherwood R, Shah AM, MacCarthy PA) Heart 2012 Nov;98(22):1641-6 PMID: 22914532 08/24/2012       28 Citations
  • Left atrial appendage occlusion: lessons learned from surgical and transcatheter experiences. (Chatterjee S, Alexander JC, Pearson PJ, Feldman T) Ann Thorac Surg 2011 Dec;92(6):2283-92 PMID: 22029943 10/28/2011       50 Citations
  • The additive value of three-dimensional derived left atrial volume and carotid imaging in dobutamine stress echocardiography. (Sachpekidis V, Bhan A, Paul M, Gianstefani S, Smith L, Reiken J, Walker N, Harries D, Pearson P, Monaghan MJ) Eur J Echocardiogr 2011 Jan;12(1):46-53 PMID: 20829208 09/11/2010       2 Citations
  • Adaptation of bioassay to detect endothelium-derived relaxing factors from the canine atrial endocardium. (Chua YL, Evora PR, Celotto AC, Pearson PJ, Discigil B, Schaff HV) Rev Bras Cir Cardiovasc 2009 Apr-Jun;24(2):225-32 PMID: 19768303 09/22/2009       1 Citations
  • Effect of the effluent released from the canine internal mammary artery after intraluminal and extraluminal perfusion of acetylcholine and adenosine diphosphate. (Matsuda NM, Pearson PJ, Schaff HV, Piccinato CE, Rodrigues AJ, Evora PR) J Biomed Sci 2009 May 05;16:45 PMID: 19416519 PMCID: PMC2686693 05/07/2009       1 Citations
  • Comparisons of the release of vasodilator substances from left and right cardiac chambers of the isolated perfused rabbit heart: implications for intraventricular thrombus formation. (Discigil B, Chua YL, Pearson PJ, Evora PR, Celotto AC, Schaff HV) Nitric Oxide 2009 Jun;20(4):259-63 PMID: 19232543 02/24/2009       1 Citations
  • High-frequency ultrasonic waves cause endothelial dysfunction on canine epicardial coronary arteries. (Discigil B, King RM, Pearson PJ, Capellini VK, Rodrigues AJ, Schaff HV, Evora PR) Rev Bras Cir Cardiovasc 2008 Apr-Jun;23(2):190-6 PMID: 18820781 09/30/2008       1 Citations
  • Diagnostic and therapeutic performance of video-assisted thoracoscopic surgery (VATS) in investigation and management of pleural exudates. (Medford AR, Awan YM, Marchbank A, Rahamim J, Unsworth-White J, Pearson PJ) Ann R Coll Surg Engl 2008 Oct;90(7):597-600 PMID: 18701011 PMCID: PMC2728309 08/15/2008       12 Citations
  • Nitric oxide and prostacyclin-dependent pathways involvement on in vitro induced hypothermia. (Evora PR, Cable DG, Chua YL, Rodrigues AJ, Pearson PJ, Schaff HV) Cryobiology 2007 Feb;54(1):106-13 PMID: 17274973 02/06/2007       16 Citations
  • Endothelium-dependent vasodilation during acute rejection in dogs. (Pearson PJ, Wei CM, Lin PJ, Burnett JC, Cable DG, Hamner CE, Schaff HV) J Surg Res 2004 Sep;121(1):56-61 PMID: 15313376 08/18/2004       2 Citations
  • A novel antioxidant, EPC-K1, stimulates endothelial nitric oxide production and scavenges hydroxyl radicals. (Takayama H, Hamner CE, Caccitolo JA, Hisamochi K, Pearson PJ, Schaff HV) Circ J 2003 Dec;67(12):1046-52 PMID: 14639022 11/26/2003       11 Citations
  • Endothelium-dependent relaxation in response to poly-L-arginine in canine coronary arteries: implications about hyperpolarization as a mechanism of vasodilatation. (Evora PR, Pearson PJ, Rodrigues AJ, Viaro F, Schaff HV) Arq Bras Cardiol 2003 Jun;80(6):626-30; 621-5 PMID: 12856072 07/12/2003       1 Citations
  • Endothelium-dependent relaxation to poly-L-arginine in canine coronary arteries. (Rodrigues AJ, Evora PR, Pearson PJ, Schaff HV) Endothelium 2003;10(2):79-87 PMID: 12791515 06/07/2003       1 Citations
  • Effect of arginine vasopressin on the canine epicardial coronary artery: experiments on V1-receptor-mediated production of nitric oxide. (Evora PR, Pearson PJ, Rodrigues AJ, Viaro F, Schaff HV) Arq Bras Cardiol 2003 May;80(5):483-94 PMID: 12792714 06/07/2003       10 Citations
  • Pharmacological studies on internal mammary artery bypass grafts. Action of endogenous and exogenous vasodilators and vasoconstrictors. (Evora PR, Pearson PJ, Discigil B, Oeltjen MR, Schaff HV) J Cardiovasc Surg (Torino) 2002 Dec;43(6):761-71 PMID: 12483164 12/17/2002       9 Citations
  • Exogenous hyaluronidase induces release of nitric oxide from the coronary endothelium. (Evora PR, Pearson PJ, Chua YL, Discigil B, Schaff HV) J Thorac Cardiovasc Surg 2000 Oct;120(4):707-11 PMID: 11003752 09/26/2000       7 Citations
  • Endothelium-dependent vasodilation in response to Pseudomonas aeruginosa lipopolysaccharide: an in vitro study on canine arteries. (Evora PR, Ekin S, Pearson PJ, Schaff HV) Braz J Med Biol Res 1998 Oct;31(10):1329-34 PMID: 9876305 01/07/1999       5 Citations
  • New approaches to prevention and treatment of radial artery graft vasospasm. (Cable DG, Caccitolo JA, Pearson PJ, O'Brien T, Mullany CJ, Daly RC, Orszulak TA, Schaff HV) Circulation 1998 Nov 10;98(19 Suppl):II15-21; discussion II21-2 PMID: 9852874 12/16/1998       103 Citations
  • Effects of cardioplegic solutions on vasoreactivity of the internal mammary artery. (Pearson PJ, Schaff HV) Ann Thorac Surg 1998 Aug;66(2):311-2 PMID: 9725361 09/02/1998    
  • Hypoxia increases vasodilator release from internal mammary artery and saphenous vein grafts. (Pearson PJ, Evora PR, Discigil B, Schaff HV) Ann Thorac Surg 1998 May;65(5):1220-5 PMID: 9594841 05/22/1998       16 Citations
  • Hypomagnesemia inhibits nitric oxide release from coronary endothelium: protective role of magnesium infusion after cardiac operations. (Pearson PJ, Evora PR, Seccombe JF, Schaff HV) Ann Thorac Surg 1998 Apr;65(4):967-72 PMID: 9564911 05/16/1998       91 Citations
  • Nitric oxide and endothelium-derived vasoactive factors: role in the vascular tone control. (Evora PRB, Pearson PJ, Discigil B, Seccombe JF, Oeltjen M, Schaff HV) Rev Soc Cardiol Estado de San Paulo 6(2):129-137 09/05/1996    
  • Cardioplegia cristaloide, barotrauma e funcao endotelial: consideracoes experimentalais (Evora PRB, Pearson PJ, Oeltjen M, Discigil B, Schaff HV) Rev Bras Cir Cardiovasc 11(2):115-122 09/05/1996    
  • Augmented endothelium-dependent constriction to hypoxia early and late following reperfusion of the canine coronary artery. (Pearson PJ, Lin PJ, Schaff HV, Vanhoutte PM) Clin Exp Pharmacol Physiol 1996 Aug;23(8):634-41 PMID: 8886481 08/01/1996       27 Citations
  • [Experimental methods in the study of endothelial function]. (Evora PR, Pearson PJ, Seccombe JF, Discigil B, Schaff HV) Arq Bras Cardiol 1996 May;66(5):291-7 PMID: 9008914 05/01/1996       2 Citations
  • [Ischemia-reperfusion lesion. Physiopathologic aspects and the importance of the endothelial function]. (Evora PR, Pearson PJ, Seccombe JF, Schaff HV) Arq Bras Cardiol 1996 Apr;66(4):239-45 PMID: 8935692 04/01/1996       8 Citations
  • Protamine induces endothelium-dependent vasodilatation of the pulmonary artery. (Evora PR, Pearson PJ, Schaff HV) Ann Thorac Surg 1995 Aug;60(2):405-10 PMID: 7646104 08/01/1995       27 Citations
  • Novel technique to bioassay endocardium-derived nitric oxide from the beating heart. (Discigil B, Pearson PJ, Chua YL, Evora PR, Seccombe JF, Schaff HV) Ann Thorac Surg 1995 May;59(5):1182-6 PMID: 7733717 05/01/1995       7 Citations
  • Impaired endothelium-dependent relaxation after coronary reperfusion injury: evidence for G-protein dysfunction. (Evora PR, Pearson PJ, Schaff HV) Ann Thorac Surg 1994 Jun;57(6):1550-6 PMID: 8010801 06/01/1994       35 Citations
  • Oxygen radical-mediated vascular injury selectively inhibits receptor-dependent release of nitric oxide from canine coronary arteries. (Seccombe JF, Pearson PJ, Schaff HV) J Thorac Cardiovasc Surg 1994 Feb;107(2):505-9 PMID: 8302070 02/01/1994       51 Citations
  • Detection of intraluminal release of endothelium-derived relaxing factor from human saphenous veins. (Chua YL, Pearson PJ, Evora PR, Schaff HV) Circulation 1993 Nov;88(5 Pt 2):II128-32 PMID: 8222147 11/01/1993       20 Citations
  • Alguns aspectos da funcao endotelial em cirurgia cardiaca. (Evora PRB, Pearson PJ, Schaff HV) Rev Bras Circ Cardiovasc 8(3):195-214 09/05/1993    
  • Protamine impairs endothelium-dependent relaxation in canine coronary arteries. (Seccombe, JF, Oeltjen MR, Pearson PJ, Schaff HV) Surgical Forum XLIV:276-279 09/05/1993    
  • Endothelium-derived contracting factors. (Lin PJ, Pearson PJ, Chang CH) Changgeng Yi Xue Za Zhi 1993 Sep;16(3):140-53 PMID: 8221287 09/01/1993    
  • [Endothelial function and coronary vasospasm after heart surgery]. (Evora PR, Pearson PJ, Schaff HV) Arq Bras Cardiol 1993 Aug;61(2):119-25 PMID: 8297221 08/01/1993    
  • Thromboxane A2: an endothelium-derived vasoconstrictor in human internal mammary arteries. (Lin PJ, Chang CH, Pearson PJ, Tzen KY, Chu JJ, Chang JP, Hsieh MJ) Ann Thorac Surg 1993 Jul;56(1):97-100 PMID: 8328883 07/01/1993       25 Citations
  • One-hour exposure to University of Wisconsin solution does not impair endothelium-dependent relaxation or damage vascular smooth muscle of epicardial coronary arteries. (Ekin ST, Pearson PJ, Evora PR, Schaff HV) J Heart Lung Transplant 1993 Jul-Aug;12(4):624-33 PMID: 8369325 07/01/1993       12 Citations
  • Arginine vasopressin induces endothelium-dependent vasodilatation of the pulmonary artery. V1-receptor-mediated production of nitric oxide. (Evora PR, Pearson PJ, Schaff HV) Chest 1993 Apr;103(4):1241-5 PMID: 8131474 04/01/1993       137 Citations
  • Endothelium-derived relaxing factors. (Lin PJ, Pearson PJ, Chang CH) Changgeng Yi Xue Za Zhi 1993 Mar;16(1):1-13 PMID: 8098260 03/01/1993       1 Citations
  • Endothelium-dependent response of human internal mammary artery to hypoxia. (Pearson PJ, Lin PJ, Evora PR, Schaff HV) Am J Physiol 1993 Feb;264(2 Pt 2):H376-80 PMID: 8447453 02/01/1993       28 Citations
  • Nitric oxide is (or is not) everywhere! (Thirlby RC, Pearson PJ) Gastroenterology 1993 Feb;104(2):658-9 PMID: 7678828 02/01/1993       4 Citations
  • Vasodilator and vasoconstrictor substances produced by the endothelium. (Pearson PJ, Vanhoutte PM) Rev Physiol Biochem Pharmacol 1993;122:1-67 PMID: 8265963 01/01/1993       51 Citations
  • Bioassay of EDRF from internal mammary arteries: implications for early and late bypass graft patency. (Pearson PJ, Evora PR, Schaff HV) Ann Thorac Surg 1992 Dec;54(6):1078-84 PMID: 1449290 12/01/1992       68 Citations
  • Crystalloid cardioplegia and hypothermia do not impair endothelium-dependent relaxation or damage vascular smooth muscle of epicardial coronary arteries. (Evora PR, Pearson PJ, Schaff HV) J Thorac Cardiovasc Surg 1992 Nov;104(5):1365-74 PMID: 1434718 11/01/1992       44 Citations
  • Protamine releases endothelium-derived relaxing factor from systemic arteries. A possible mechanism of hypotension during heparin neutralization. (Pearson PJ, Evora PR, Ayrancioglu K, Schaff HV) Circulation 1992 Jul;86(1):289-94 PMID: 1617779 07/01/1992       55 Citations
  • Global myocardial ischemia and reperfusion impair endothelium-dependent relaxations to aggregating platelets in the canine coronary artery. A possible cause of vasospasm after cardiopulmonary bypass. (Pearson PJ, Lin PJ, Schaff HV) J Thorac Cardiovasc Surg 1992 Jun;103(6):1147-54 PMID: 1597979 06/01/1992       48 Citations
  • Endothelial cell dysfunction after ischemic arrest and reperfusion: a possible mechanism of myocardial injury during reflow. (Hashimoto K, Pearson PJ, Schaff HV, Cartier R) J Thorac Cardiovasc Surg 1991 Nov;102(5):688-94 PMID: 1943187 11/01/1991       70 Citations
  • Superoxide anion mediates the endothelium-dependent contractions to serotonin by regenerated endothelium. (Lin PJ, Pearson PJ, Cartier R, Schaff HV) J Thorac Cardiovasc Surg 1991 Sep;102(3):378-85 PMID: 1652668 09/01/1991       31 Citations
  • Vasoconstriction to hypoxia of the human internal mammary artery. (Lin PJ, Pearson PJ, Schaff HV) Changgeng Yi Xue Za Zhi 1991 Sep;14(3):141-8 PMID: 1933621 09/01/1991    
  • Time course and extent of recovery of endothelium-dependent contractions and relaxations after direct arterial injury. (Cartier R, Pearson PJ, Lin PJ, Schaff HV) J Thorac Cardiovasc Surg 1991 Sep;102(3):371-7 PMID: 1881177 09/01/1991       29 Citations
  • Endothelium-dependent contraction and relaxation of the human and canine internal mammary artery: studies on bypass graft vasospasm. (Lin PJ, Pearson PJ, Schaff HV) Surgery 1991 Aug;110(2):127-34; discussion 135 PMID: 1858024 08/01/1991       26 Citations
  • Production of endothelium-derived contracting factor is enhanced after coronary reperfusion. (Pearson PJ, Lin PJ, Schaff HV) Ann Thorac Surg 1991 May;51(5):788-93 PMID: 1902653 05/01/1991       40 Citations
  • Hypoxia releases a vasoconstrictor substance from the human internal mammary artery endothelium. (Lin PJ, Pearson PJ, Schaff HV) Surgical Forum XLI:312-313 09/05/1990    
  • Endothelial dysfunction following global cardiac ischemia and reperfusion. (McAfee M, Hashimoto H, Pearson PJ, Schaff HV) Surgical Forum XLI:310-311 09/05/1990    
  • Acute impairment of endothelium-dependent relaxations to aggregating platelets following reperfusion injury in canine coronary arteries. (Pearson PJ, Schaff HV, Vanhoutte PM) Circ Res 1990 Aug;67(2):385-93 PMID: 2115821 08/01/1990       129 Citations
  • Long-term impairment of endothelium-dependent relaxations to aggregating platelets after reperfusion injury in canine coronary arteries. (Pearson PJ, Schaff HV, Vanhoutte PM) Circulation 1990 Jun;81(6):1921-7 PMID: 2344684 06/01/1990       119 Citations
  • Therapy using reproductive hormones. Vet Rec 1989 Apr 29;124(17):471 PMID: 2728309 04/29/1989    
  • Inoperable plasma cell granuloma of the heart: spontaneous decrease in size during an 11-month period. (Pearson PJ, Smithson WA, Driscoll DJ, Banks PM, Ehman RL) Mayo Clin Proc 1988 Oct;63(10):1022-5 PMID: 3172851 10/01/1988       37 Citations
  • Diabetic children's camps. (Boucher A) Australas Nurses J 1979 Apr;8(7):13, 19 PMID: 112960 04/01/1979    
  • Pre-operative magnesium trisilicate in children. (Hutchinson BR) Anaesth Intensive Care 1978 Feb;6(1):85-6 PMID: 27128 02/01/1978    
  • Nutrition Canada: dental report. (French SB) Can Dent Hyg 1977;11(4):78-9 PMID: 277279 01/01/1977    
  • Dehydrogenation of reduced pyridine nucleotides by Leydig cell tumors of the rat testis. (Schor NA, Rice BF, Huseby RA, Dunlap CE) Proc Soc Exp Biol Med 1976 Feb;151(2):418-21 PMID: 2936 02/01/1976       9 Citations
  • Last update: 01/16/2019
    jenkins-FCD Prod-299 9ef562391eceb2b8f95265c767fbba1ce5a52fd6