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Ellis D. Avner MD

Ellis D. Avner MD

Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Nephrology


Leadership Positions

  • Associate Dean for Research
  • Founding Director, Children's Research Institute
  • Director, Research Center of Excellence in Pediatric Nephrology
  • Publications

  • Identification of molecular signatures of cystic fibrosis disease status with plasma-based functional genomics. (Levy H, Jia S, Pan A, Zhang X, Kaldunski M, Nugent ML, Reske M, Feliciano RA, Quintero D, Renda MM, Woods KJ, Murkowski K, Johnson K, Verbsky J, Dasu T, Ideozu JE, McColley S, Quasney MW, Dahmer MK, Avner E, Farrell PM, Cannon CL, Jacob H, Simpson PM, Hessner MJ) Physiol Genomics 2019 Jan 01;51(1):27-41 PMID: 30540547 12/13/2018    
  • Unique interstitial miRNA signature drives fibrosis in a murine model of autosomal dominant polycystic kidney disease. (Patil A, Sweeney WE Jr, Pan CG, Avner ED) World J Nephrol 2018 09 07;7(5):108-116 PMID: 30211029 PMCID: PMC6134266 09/14/2018    
  • Tesevatinib ameliorates progression of polycystic kidney disease in rodent models of autosomal recessive polycystic kidney disease. (Sweeney WE, Frost P, Avner ED) World J Nephrol 2017 Jul 06;6(4):188-200 PMID: 28729967 PMCID: PMC5500456 07/22/2017    
  • Emerging Therapies for Childhood Polycystic Kidney Disease. (Sweeney WE Jr, Avner ED) Front Pediatr 2017;5:77 PMID: 28473970 PMCID: PMC5395658 05/06/2017    
  • Pathophysiology of childhood polycystic kidney diseases: new insights into disease-specific therapy. (Sweeney WE Jr, Avner ED) Pediatr Res 2014 Jan;75(1-2):148-57 PMID: 24336431 PMCID: PMC3953890 12/18/2013       20 Citations
  • Smac-mimetic-induced epithelial cell death reduces the growth of renal cysts. (Fan LX, Zhou X, Sweeney WE Jr, Wallace DP, Avner ED, Grantham JJ, Li X) J Am Soc Nephrol 2013 Dec;24(12):2010-22 PMID: 23990677 PMCID: PMC3839552 08/31/2013       13 Citations
  • Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease. (Zhou X, Fan LX, Sweeney WE Jr, Denu JM, Avner ED, Li X) J Clin Invest 2013 Jul;123(7):3084-98 PMID: 23778143 PMCID: PMC4101988 06/20/2013       49 Citations
  • New approaches to the autosomal recessive polycystic kidney disease patient with dual kidney-liver complications. (Telega G, Cronin D, Avner ED) Pediatr Transplant 2013 Jun;17(4):328-35 PMID: 23593929 PMCID: PMC3663883 04/19/2013       25 Citations
  • G-protein signaling modulator 1 deficiency accelerates cystic disease in an orthologous mouse model of autosomal dominant polycystic kidney disease. (Kwon M, Pavlov TS, Nozu K, Rasmussen SA, Ilatovskaya DV, Lerch-Gaggl A, North LM, Kim H, Qian F, Sweeney WE Jr, Avner ED, Blumer JB, Staruschenko A, Park F) Proc Natl Acad Sci U S A 2012 Dec 26;109(52):21462-7 PMID: 23236168 PMCID: PMC3535663 12/14/2012       18 Citations
  • HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells. (Liu W, Fan LX, Zhou X, Sweeney WE Jr, Avner ED, Li X) PLoS One 2012;7(11):e49418 PMID: 23152903 PMCID: PMC3496684 11/16/2012       32 Citations
  • Role of genetic modifiers in an orthologous rat model of ARPKD. (O'Meara CC, Hoffman M, Sweeney WE Jr, Tsaih SW, Xiao B, Jacob HJ, Avner ED, Moreno C) Physiol Genomics 2012 Aug 01;44(15):741-53 PMID: 22669842 PMCID: PMC3774585 06/07/2012       12 Citations
  • Transport, cilia, and PKD: must we in (cyst) on interrelationships? Focus on "Increased Na+/H+ exchanger activity on the apical surface of a cilium-deficient cortical collecting duct principal cell model of polycystic kidney disease". (Avner ED, McDonough AA, Sweeney WE Jr) Am J Physiol Cell Physiol 2012 May 15;302(10):C1434-5 PMID: 22403786 PMCID: PMC3362002 03/10/2012       4 Citations
  • Loss of activator of G-protein signaling 3 impairs renal tubular regeneration following acute kidney injury in rodents. (Regner KR, Nozu K, Lanier SM, Blumer JB, Avner ED, Sweeney WE Jr, Park F) FASEB J 2011 Jun;25(6):1844-55 PMID: 21343176 PMCID: PMC3101034 02/24/2011       26 Citations
  • Diagnosis and management of childhood polycystic kidney disease. (Sweeney WE Jr, Avner ED) Pediatr Nephrol 2011 May;26(5):675-92 PMID: 21046169 11/04/2010       67 Citations
  • Birth of a healthy infant following preimplantation PKHD1 haplotyping for autosomal recessive polycystic kidney disease using multiple displacement amplification. (Lau EC, Janson MM, Roesler MR, Avner ED, Strawn EY, Bick DP) J Assist Reprod Genet 2010 Jul;27(7):397-407 PMID: 20490649 PMCID: PMC2922704 05/22/2010       16 Citations
  • 20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism. (Akbulut T, Regner KR, Roman RJ, Avner ED, Falck JR, Park F) Am J Physiol Renal Physiol 2009 Sep;297(3):F662-70 PMID: 19570883 PMCID: PMC2739708 07/03/2009       37 Citations
  • Chronic blockade of 20-HETE synthesis reduces polycystic kidney disease in an orthologous rat model of ARPKD. (Park F, Sweeney WE Jr, Jia G, Akbulut T, Mueller B, Falck JR, Birudaraju S, Roman RJ, Avner ED) Am J Physiol Renal Physiol 2009 Mar;296(3):F575-82 PMID: 19129252 PMCID: PMC2660198 01/09/2009       18 Citations
  • 20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease. (Park F, Sweeney WE, Jia G, Roman RJ, Avner ED) J Am Soc Nephrol 2008 Oct;19(10):1929-39 PMID: 18596124 PMCID: PMC2551562 07/04/2008       36 Citations
  • Src inhibition ameliorates polycystic kidney disease. (Sweeney WE Jr, von Vigier RO, Frost P, Avner ED) J Am Soc Nephrol 2008 Jul;19(7):1331-41 PMID: 18385429 PMCID: PMC2440293 04/04/2008       94 Citations
  • Renal cystic disease: new insights for the clinician. (Avner ED, Sweeney WE Jr) Pediatr Clin North Am 2006 Oct;53(5):889-909, ix PMID: 17027616 10/10/2006       17 Citations
  • Autosomal recessive polycystic kidney disease and congenital hepatic fibrosis: summary statement of a first National Institutes of Health/Office of Rare Diseases conference. (Gunay-Aygun M, Avner ED, Bacallao RL, Choyke PL, Flynn JT, Germino GG, Guay-Woodford L, Harris P, Heller T, Ingelfinger J, Kaskel F, Kleta R, LaRusso NF, Mohan P, Pazour GJ, Shneider BL, Torres VE, Wilson P, Zak C, Zhou J, Gahl WA) J Pediatr 2006 Aug;149(2):159-64 PMID: 16887426 PMCID: PMC2918414 08/05/2006       52 Citations
  • Molecular and cellular pathophysiology of autosomal recessive polycystic kidney disease (ARPKD). (Sweeney WE Jr, Avner ED) Cell Tissue Res 2006 Dec;326(3):671-85 PMID: 16767405 06/13/2006       71 Citations
  • Haplotype analysis improves molecular diagnostics of autosomal recessive polycystic kidney disease. (Consugar MB, Anderson SA, Rossetti S, Pankratz VS, Ward CJ, Torra R, Coto E, El-Youssef M, Kantarci S, Utsch B, Hildebrandt F, Sweeney WE, Avner ED, Torres VE, Cunningham JM, Harris PC) Am J Kidney Dis 2005 Jan;45(1):77-87 PMID: 15696446 02/08/2005       26 Citations
  • Epidermal growth factor receptor tyrosine kinase inhibition is not protective in PCK rats. (Torres VE, Sweeney WE Jr, Wang X, Qian Q, Harris PC, Frost P, Avner ED) Kidney Int 2004 Nov;66(5):1766-73 PMID: 15496147 10/22/2004       59 Citations
  • EGF-related growth factors in the pathogenesis of murine ARPKD. (MacRae Dell K, Nemo R, Sweeney WE Jr, Avner ED) Kidney Int 2004 Jun;65(6):2018-29 PMID: 15149315 05/20/2004       43 Citations
  • Survival of childhood polycystic kidney disease following renal transplantation: the impact of advanced hepatobiliary disease. (Davis ID, Ho M, Hupertz V, Avner ED) Pediatr Transplant 2003 Oct;7(5):364-9 PMID: 14738296 01/24/2004       46 Citations
  • EGF receptor tyrosine kinase inhibition attenuates the development of PKD in Han:SPRD rats. (Torres VE, Sweeney WE Jr, Wang X, Qian Q, Harris PC, Frost P, Avner ED) Kidney Int 2003 Nov;64(5):1573-9 PMID: 14531789 10/09/2003       102 Citations
  • Combination treatment of PKD utilizing dual inhibition of EGF-receptor activity and ligand bioavailability. (Sweeney WE Jr, Hamahira K, Sweeney J, Garcia-Gatrell M, Frost P, Avner ED) Kidney Int 2003 Oct;64(4):1310-9 PMID: 12969149 09/13/2003       52 Citations
  • Effect of the peritoneal dialysis prescription on pentosidine in children. (Bayazit AK, Vogt BA, Dell KM, Davis ID, Noyan A, Anarat A, Avner ED, Erhard P, Weiss MF) Pediatr Nephrol 2003 Oct;18(10):1049-54 PMID: 12898376 08/05/2003       6 Citations
  • Polycystin-1 distribution is modulated by polycystin-2 expression in mammalian cells. (Grimm DH, Cai Y, Chauvet V, Rajendran V, Zeltner R, Geng L, Avner ED, Sweeney W, Somlo S, Caplan MJ) J Biol Chem 2003 Sep 19;278(38):36786-93 PMID: 12840011 07/04/2003       68 Citations
  • Complications of peritoneal dialysis in children with Eagle-Barrett syndrome. (Wisanuyotin S, Dell KM, Vogt BA, O'Riordan MA, Avner ED, Davis ID) Pediatr Nephrol 2003 Feb;18(2):159-63 PMID: 12579407 02/13/2003       2 Citations
  • Critical choices in mentoring the next generation of academic pediatricians: nine circles of hell or salvation? (Drotar D, Avner ED) J Pediatr 2003 Jan;142(1):1-2 PMID: 12520243 01/10/2003       7 Citations
  • Refinement of the autosomal recessive polycystic kidney disease (PKHD1) interval and exclusion of an EF hand-containing gene as a PKHD1 candidate gene. (Onuchic LF, Mrug M, Hou X, Eggermann T, Bergmann C, Zerres K, Avner ED, Furu L, Somlo S, Nagasawa Y, Germino GG, Guay-Woodford LM) Am J Med Genet 2002 Jul 15;110(4):346-52 PMID: 12116208 07/13/2002       17 Citations
  • PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats. (Onuchic LF, Furu L, Nagasawa Y, Hou X, Eggermann T, Ren Z, Bergmann C, Senderek J, Esquivel E, Zeltner R, Rudnik-Schöneborn S, Mrug M, Sweeney W, Avner ED, Zerres K, Guay-Woodford LM, Somlo S, Germino GG) Am J Hum Genet 2002 May;70(5):1305-17 PMID: 11898128 PMCID: PMC447605 03/19/2002       322 Citations
  • Phenotypic analysis of conditionally immortalized cells isolated from the BPK model of ARPKD. (Sweeney WE Jr, Kusner L, Carlin CR, Chang S, Futey L, Cotton CU, Dell KM, Avner ED) Am J Physiol Cell Physiol 2001 Nov;281(5):C1695-705 PMID: 11600434 10/16/2001       19 Citations
  • A novel inhibitor of tumor necrosis factor-alpha converting enzyme ameliorates polycystic kidney disease. (Dell KM, Nemo R, Sweeney WE Jr, Levin JI, Frost P, Avner ED) Kidney Int 2001 Oct;60(4):1240-8 PMID: 11576338 09/29/2001       52 Citations
  • Can progression of autosomal dominant or autosomal recessive polycystic kidney disease be prevented? (Davis ID, MacRae Dell K, Sweeney WE, Avner ED) Semin Nephrol 2001 Sep;21(5):430-40 PMID: 11559884 09/18/2001       27 Citations
  • Expression of the orpk disease gene during kidney development and maturation. (Nakanishi K, Sweeney WE Jr, Avner ED, Murcia NS) Pediatr Nephrol 2001 Mar;16(3):219-26 PMID: 11322368 04/27/2001       5 Citations
  • Childhood ADPKD: answers and more questions. (Avner ED) Kidney Int 2001 May;59(5):1979-80 PMID: 11318972 04/25/2001       2 Citations
  • Role of CFTR in autosomal recessive polycystic kidney disease. (Nakanishi K, Sweeney WE Jr, Macrae Dell K, Cotton CU, Avner ED) J Am Soc Nephrol 2001 Apr;12(4):719-25 PMID: 11274233 03/29/2001       28 Citations
  • Renal dysfunction but not cystic change is ameliorated by neonatal epidermal growth factor in bpk mice. (Nakanishi K, Gattone VH 2nd, Sweeney WE, Avner ED) Pediatr Nephrol 2001 Jan;16(1):45-50 PMID: 11198603 02/24/2001       17 Citations
  • Segment-specific c-ErbB2 expression in human autosomal recessive polycystic kidney disease. (Nakanishi K, Sweeney W Jr, Avner ED) J Am Soc Nephrol 2001 Feb;12(2):379-84 PMID: 11158230 02/07/2001       23 Citations
  • Generation and phenotype of cell lines derived from CF and non-CF mice that carry the H-2K(b)-tsA58 transgene. (Takacs-Jarrett M, Sweeney WE, Avner ED, Cotton CU) Am J Physiol Cell Physiol 2001 Jan;280(1):C228-36 PMID: 11121394 12/21/2000       18 Citations
  • Genomic structure of the gene for the human P1 protein (MCM3) and its exclusion as a candidate for autosomal recessive polycystic kidney disease. (Hofmann Y, Becker J, Wright F, Avner ED, Mrug M, Guay-Woodford LM, Somlo S, Zerres K, Germino GG, Onuchic LF) Eur J Hum Genet 2000 Mar;8(3):163-6 PMID: 10780780 04/26/2000       7 Citations
  • Proximal tubular cysts in fetal human autosomal recessive polycystic kidney disease. (Nakanishi K, Sweeney WE Jr, Zerres K, Guay-Woodford LM, Avner ED) J Am Soc Nephrol 2000 Apr;11(4):760-3 PMID: 10752536 04/07/2000       40 Citations
  • Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor. (Sweeney WE, Chen Y, Nakanishi K, Frost P, Avner ED) Kidney Int 2000 Jan;57(1):33-40 PMID: 10620185 01/05/2000       168 Citations
  • Genomic organization of the KIAA0057 gene that encodes a TRAM-like protein and its exclusion as a polycystic kidney and hepatic disease 1 (PKHD1) candidate gene. (Onuchic LF, Mrug M, Lakings AL, Muecher G, Becker J, Zerres K, Avner ED, Dixit M, Somlo S, Germino GG, Guay-Woodford LM) Mamm Genome 1999 Dec;10(12):1175-8 PMID: 10594243 12/14/1999       7 Citations
  • Glomerulosclerosis and hypoplasia--a common theme? (Avner ED) Kidney Int 1999 Nov;56(5):1962-3 PMID: 10571808 11/26/1999       3 Citations
  • Cellular pathophysiology of cystic kidney disease: insight into future therapies. (Avner ED, Woychik RP, Dell KM, Sweeney WE) Int J Dev Biol 1999;43(5):457-61 PMID: 10535324 10/27/1999       12 Citations
  • In vitro modulation of cyst formation by a novel tyrosine kinase inhibitor. (Sweeney WE, Futey L, Frost P, Avner ED) Kidney Int 1999 Aug;56(2):406-13 PMID: 10432378 08/05/1999       41 Citations
  • Safety and efficacy of erythropoietin in children with chronic renal failure. (Brandt JR, Avner ED, Hickman RO, Watkins SL) Pediatr Nephrol 1999 Feb;13(2):143-7 PMID: 10229004 05/06/1999       42 Citations
  • New insights into the molecular pathophysiology of polycystic kidney disease. (Murcia NS, Sweeney WE Jr, Avner ED) Kidney Int 1999 Apr;55(4):1187-97 PMID: 10200981 04/14/1999       99 Citations
  • A 1-Mb BAC/PAC-based physical map of the autosomal recessive polycystic kidney disease gene (PKHD1) region on chromosome 6. (Park JH, Dixit MP, Onuchic LF, Wu G, Goncharuk AN, Kneitz S, Santarina LB, Hayashi T, Avner ED, Guay-Woodford L, Zerres K, Germino GG, Somlo S) Genomics 1999 Apr 15;57(2):249-55 PMID: 10198164 04/13/1999       20 Citations
  • Pediatric renal transplantation: indications and special considerations. A position paper from the Pediatric Committee of the American Society of Transplant Physicians. (Davis ID, Bunchman TE, Grimm PC, Benfield MR, Briscoe DM, Harmon WE, Alexander SR, Avner ED) Pediatr Transplant 1998 May;2(2):117-29 PMID: 10082443 03/19/1999       35 Citations
  • The molecular biology of polycystic kidney disease. (Murcia NS, Woychik RP, Avner ED) Pediatr Nephrol 1998 Nov;12(9):721-6 PMID: 9874315 01/05/1999       23 Citations
  • PKD and CF: an interesting family provides insight into the molecular pathophysiology of polycystic kidney disease. (Cotton CU, Avner ED) Am J Kidney Dis 1998 Dec;32(6):1081-3 PMID: 9856528 12/18/1998       10 Citations
  • Morphological and functional characterization of a conditionally immortalized collecting tubule cell line. (Takacs-Jarrett M, Sweeney WE, Avner ED, Cotton CU) Am J Physiol 1998 Nov;275(5 Pt 2):F802-11 PMID: 9815138 11/14/1998       22 Citations
  • Morphological and functional characterization of a conditionally immortalized collecting tubule cell line. (Takacs-Jarrett M, Sweeney WE, Avner ED, Cotton CU) Am J Physiol Renal Physiol 1998 Nov 01;275(5):F802-F811 PMID: 29586404 11/01/1998    
  • Functional activity of epidermal growth factor receptors in autosomal recessive polycystic kidney disease. (Sweeney WE Jr, Avner ED) Am J Physiol 1998 Sep;275(3 Pt 2):F387-94 PMID: 9729511 09/08/1998       85 Citations
  • Functional genomics in the post-genome era. (Woychik RP, Klebig ML, Justice MJ, Magnuson TR, Avner ED) Mutat Res 1998 May 25;400(1-2):3-14 PMID: 9685569 08/01/1998       37 Citations
  • Cholelithiasis following Escherichia coli O157:H7-associated hemolytic uremic syndrome. (Brandt JR, Joseph MW, Fouser LS, Tarr PI, Zelikovic I, McDonald RA, Avner ED, McAfee NG, Watkins SL) Pediatr Nephrol 1998 Apr;12(3):222-5 PMID: 9630042 06/18/1998       32 Citations
  • Cell and molecular biology of kidney development. (Orellana SA, Avner ED) Semin Nephrol 1998 May;18(3):233-43 PMID: 9613864 06/05/1998       25 Citations
  • The role of hepatocyte growth factor (HGF) at progressive stages of metanephric development. (Sweeney WE Jr, Avner ED) In Vitro Cell Dev Biol Anim 1998 Feb;34(2):189-94 PMID: 9542659 05/23/1998       1 Citations
  • Pediatric renal biopsy: should this procedure be performed in an outpatient setting? (Davis ID, Oehlenschlager W, O'Riordan MA, Avner ED) Pediatr Nephrol 1998 Feb;12(2):96-100 PMID: 9543363 04/16/1998    
  • Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney disease. (Richards WG, Sweeney WE, Yoder BK, Wilkinson JE, Woychik RP, Avner ED) J Clin Invest 1998 Mar 01;101(5):935-9 PMID: 9486961 PMCID: PMC508642 04/16/1998       159 Citations
  • Prenatal diagnosis of autosomal recessive polycystic kidney disease (ARPKD): molecular genetics, clinical experience, and fetal morphology. (Zerres K, Mücher G, Becker J, Steinkamm C, Rudnik-Schöneborn S, Heikkilä P, Rapola J, Salonen R, Germino GG, Onuchic L, Somlo S, Avner ED, Harman LA, Stockwin JM, Guay-Woodford LM) Am J Med Genet 1998 Mar 05;76(2):137-44 PMID: 9511976 03/25/1998       181 Citations
  • Efficacy of taxol in the orpk mouse model of polycystic kidney disease. (Sommardahl CS, Woychik RP, Sweeney WE, Avner ED, Wilkinson JE) Pediatr Nephrol 1997 Dec;11(6):728-33 PMID: 9438653 01/23/1998       24 Citations
  • Improved outcome of young children on nightly automated peritoneal dialysis. (Becker N, Brandt JR, Sutherland TA, Avner ED, Watkins SL) Pediatr Nephrol 1997 Dec;11(6):676-9 PMID: 9438640 01/23/1998       12 Citations
  • Differential rescue of the renal and hepatic disease in an autosomal recessive polycystic kidney disease mouse mutant. A new model to study the liver lesion. (Yoder BK, Richards WG, Sommardahl C, Sweeney WE, Michaud EJ, Wilkinson JE, Avner ED, Woychik RP) Am J Pathol 1997 Jun;150(6):2231-41 PMID: 9176412 PMCID: PMC1858312 06/01/1997       31 Citations
  • An integrated genetic and physical map of the autosomal recessive polycystic kidney disease region. (Lens XM, Onuchic LF, Wu G, Hayashi T, Daoust M, Mochizuki T, Santarina LB, Stockwin JM, Mücher G, Becker J, Sweeny WE Jr, Avner ED, Guay-Woodford L, Zerres K, Somlo S, Germino GG) Genomics 1997 May 01;41(3):463-6 PMID: 9169147 05/01/1997       29 Citations
  • Functional correction of renal defects in a mouse model for ARPKD through expression of the cloned wild-type Tg737 cDNA. (Yoder BK, Richards WG, Sommardahl C, Sweeney WE, Michaud EJ, Wilkinson JE, Avner ED, Woychik RP) Kidney Int 1996 Oct;50(4):1240-8 PMID: 8887283 10/01/1996       32 Citations
  • Evidence that two phenotypically distinct mouse PKD mutations, bpk and jcpk, are allelic. (Guay-Woodford LM, Bryda EC, Christine B, Lindsey JR, Collier WR, Avner ED, D'Eustachio P, Flaherty L) Kidney Int 1996 Oct;50(4):1158-65 PMID: 8887273 10/01/1996       30 Citations
  • Novel Madin Darby canine kidney cell clones exhibit unique phenotypes in response to morphogens. (Orellana SA, Neff CD, Sweeney WE, Avner ED) In Vitro Cell Dev Biol Anim 1996 Jun;32(6):329-39 PMID: 8842747 06/01/1996       12 Citations
  • Alternate-day steroid dosing improves growth without adversely affecting graft survival or long-term graft function. A report of the North American Pediatric Renal Transplant Cooperative Study. (Jabs K, Sullivan EK, Avner ED, Harmon WE) Transplantation 1996 Jan 15;61(1):31-6 PMID: 8560569 01/15/1996       106 Citations
  • Clinical quiz. Differential diagnosis of a patient with Wegener's granulomatosis. (Becker N, Rutledge JC, Avner ED) Pediatr Nephrol 1995 Dec;9(6):785-7 PMID: 8747127 12/01/1995       1 Citations
  • Clinical quiz. Differential diagnosis of a patient with hypertension. (Holleman R, Avner ED) Pediatr Nephrol 1995 Dec;9(6):783-4 PMID: 8747126 12/01/1995    
  • Congenital nephropathies and uropathies. (Becker N, Avner ED) Pediatr Clin North Am 1995 Dec;42(6):1319-41 PMID: 8614589 12/01/1995       16 Citations
  • 1 alpha, 25-dihydroxyvitamin D3 receptor ontogenesis in fetal renal development. (Johnson JA, Grande JP, Roche PC, Sweeney WE Jr, Avner ED, Kumar R) Am J Physiol 1995 Sep;269(3 Pt 2):F419-28 PMID: 7573491 09/11/1995       24 Citations
  • Metabolic studies of rat renal tubule cells loaded with cystine: the cystine dimethylester model of cystinosis. (Foreman JW, Benson LL, Wellons M, Avner ED, Sweeney W, Nissim I, Nissim I) J Am Soc Nephrol 1995 Aug;6(2):269-72 PMID: 7579095 08/01/1995       35 Citations
  • Cystic maldevelopment of the kidney. (Orellana SA, Avner ED) Semin Nephrol 1995 Jul;15(4):341-52 PMID: 7569413 07/01/1995       23 Citations
  • Biliary epithelial cells from mice with congenital polycystic kidney disease are hyperresponsive to epidermal growth factor. (Nauta J, Sweeney WE, Rutledge JC, Avner ED) Pediatr Res 1995 Jun;37(6):755-63 PMID: 7651760 06/01/1995       39 Citations
  • The severe perinatal form of autosomal recessive polycystic kidney disease maps to chromosome 6p21.1-p12: implications for genetic counseling. (Guay-Woodford LM, Muecher G, Hopkins SD, Avner ED, Germino GG, Guillot AP, Herrin J, Holleman R, Irons DA, Primack W) Am J Hum Genet 1995 May;56(5):1101-7 PMID: 7726165 PMCID: PMC1801440 05/01/1995       140 Citations
  • Hypercalciuria and nephrocalcinosis in the oculocerebrorenal syndrome. (Sliman GA, Winters WD, Shaw DW, Avner ED) J Urol 1995 Apr;153(4):1244-6 PMID: 7869519 04/01/1995       35 Citations
  • Tyrosine kinase activity of the EGF receptor in murine metanephric organ culture. (Pugh JL, Sweeney WE Jr, Avner ED) Kidney Int 1995 Mar;47(3):774-81 PMID: 7752576 03/01/1995       50 Citations
  • Renal transplantation and chronic dialysis in children and adolescents: the 1993 annual report of the North American Pediatric Renal Transplant Cooperative Study. (Avner ED, Chavers B, Sullivan EK, Tejani A) Pediatr Nephrol 1995 Feb;9(1):61-73 PMID: 7742226 02/01/1995       63 Citations
  • Epidermal growth factor receptor expression is abnormal in murine polycystic kidney. (Orellana SA, Sweeney WE, Neff CD, Avner ED) Kidney Int 1995 Feb;47(2):490-9 PMID: 7723235 02/01/1995       115 Citations
  • Clinical disorders of water metabolism: hyponatremia and hypernatremia. (Avner ED) Pediatr Ann 1995 Jan;24(1):23-30 PMID: 7715960 01/01/1995       17 Citations
  • Introduction: Fluid and Electrolytes. (Avner ED) Pediatr Ann 1995 Jan 1;24(1):15 PMID: 24856964 01/01/1995    
  • Escherichia coli O 157:H7-associated hemolytic-uremic syndrome after ingestion of contaminated hamburgers. (Brandt JR, Fouser LS, Watkins SL, Zelikovic I, Tarr PI, Nazar-Stewart V, Avner ED) J Pediatr 1994 Oct;125(4):519-26 PMID: 7931869 10/01/1994       108 Citations
  • Gene time for polycystic kidney disease. (Avner ED) Lancet 1994 Sep 24;344(8926):833-4 PMID: 7916394 09/24/1994       3 Citations
  • Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice. (Moyer JH, Lee-Tischler MJ, Kwon HY, Schrick JJ, Avner ED, Sweeney WE, Godfrey VL, Cacheiro NL, Wilkinson JE, Woychik RP) Science 1994 May 27;264(5163):1329-33 PMID: 8191288 05/27/1994       284 Citations
  • Renal developmental diseases. (Avner ED) Semin Nephrol 1993 Sep;13(5):427-35 PMID: 8210806 09/01/1993       14 Citations
  • Renal and biliary abnormalities in a new murine model of autosomal recessive polycystic kidney disease. (Nauta J, Ozawa Y, Sweeney WE Jr, Rutledge JC, Avner ED) Pediatr Nephrol 1993 Apr;7(2):163-72 PMID: 8476712 04/01/1993       91 Citations
  • A new murine model of autosomal recessive polycystic kidney disease. (Ozawa Y, Nauta J, Sweeney WE, Avner ED) Nihon Jinzo Gakkai Shi 1993 Apr;35(4):349-54 PMID: 8341011 04/01/1993       4 Citations
  • Normal and abnormal nephrogenesis. (Fouser L, Avner ED) Am J Kidney Dis 1993 Jan;21(1):64-70 PMID: 8418629 01/01/1993       16 Citations
  • Epithelial polarity and differentiation in polycystic kidney disease. (Avner ED) J Cell Sci Suppl 1993;17:217-22 PMID: 8144700 01/01/1993       35 Citations
  • Abnormal sodium pump distribution during renal tubulogenesis in congenital murine polycystic kidney disease. (Avner ED, Sweeney WE Jr, Nelson WJ) Proc Natl Acad Sci U S A 1992 Aug 15;89(16):7447-51 PMID: 1323837 PMCID: PMC49727 08/25/1992       86 Citations
  • The case against screening urinalyses for asymptomatic bacteriuria in children. (Kemper KJ, Avner ED) Am J Dis Child 1992 Mar;146(3):343-6 PMID: 1543183 03/01/1992       38 Citations
  • Pathophysiology of renal tubular cyst formation in murine models of polycystic kidney disease. (Sweeney WE Jr, Avner ED) Contrib Nephrol 1992;97:23-34 PMID: 1633715 01/11/1992       3 Citations
  • Inherited polycystic kidney disease in children. (McDonald RA, Avner ED) Semin Nephrol 1991 Nov;11(6):632-42 PMID: 1767136 11/01/1991       34 Citations
  • Localization of arginine biosynthetic enzymes in renal proximal tubules and abundance of mRNA during development. (Morris SM Jr, Sweeney WE Jr, Kepka DM, O'Brien WE, Avner ED) Pediatr Res 1991 Feb;29(2):151-4 PMID: 2014150 02/01/1991       29 Citations
  • Polypeptide growth factors and the kidney: a developmental perspective. (Avner ED) Pediatr Nephrol 1990 Jul;4(4):345-53 PMID: 2206902 07/01/1990       29 Citations
  • Polypeptide growth factors in metanephric growth and segmental nephron differentiation. (Avner ED, Sweeney WE Jr) Pediatr Nephrol 1990 Jul;4(4):372-7 PMID: 2206907 07/01/1990       66 Citations
  • In vitro modulation of tubular cyst regression in murine polycystic kidney disease. (Avner ED, Sweeney WE Jr, Ellis D) Kidney Int 1989 Dec;36(6):960-8 PMID: 2557482 12/01/1989       17 Citations
  • Choice of urine sample predictive of microalbuminuria in patients with insulin-dependent diabetes mellitus. (Ellis D, Coonrod BA, Dorman JS, Kelsey SF, Becker DJ, Avner ED, Orchard TJ) Am J Kidney Dis 1989 Apr;13(4):321-8 PMID: 2705450 04/01/1989       76 Citations
  • Abundance of mRNAs encoding urea cycle enzymes in fetal and neonatal mouse liver. (Morris SM Jr, Kepka DM, Sweeney WE Jr, Avner ED) Arch Biochem Biophys 1989 Feb 15;269(1):175-80 PMID: 2464968 02/15/1989       33 Citations
  • Regulation of glucocorticoid receptors and Na-K ATPase activity by hydrocortisone in proximal tubular epithelial cells. (Ellis D, Sothi TD, Curthoys NP, Ballou B, Avner ED) In Vitro Cell Dev Biol 1988 Aug;24(8):811-6 PMID: 2900828 08/01/1988       3 Citations
  • Congenital murine polycystic kidney disease. II. Pathogenesis of tubular cyst formation. (Avner ED, Sweeney WE Jr, Young MC, Ellis D) Pediatr Nephrol 1988 Apr;2(2):210-8 PMID: 2856368 04/01/1988       27 Citations
  • Immunocytochemical localization of gamma-glutamyltranspeptidase during fetal development of mouse kidney. (Curto KA, Sweeney WE, Avner ED, Piesco NP, Curthoys NP) J Histochem Cytochem 1988 Feb;36(2):159-66 PMID: 2891746 02/01/1988       25 Citations
  • Renal cystic disease. Insights from recent experimental investigations. (Avner ED) Nephron 1988;48(2):89-93 PMID: 3278246 01/01/1988       14 Citations
  • Renal epithelial development in organotypic culture. (Avner ED, Piesco NP, Sweeney WE Jr, Ellis D) Pediatr Nephrol 1988 Jan;2(1):92-9 PMID: 3153007 01/01/1988       16 Citations
  • Glucocorticoids modulate renal glucocorticoid receptors and Na-K ATPase activity. (Ellis D, Sothi TD, Avner ED) Kidney Int 1987 Oct;32(4):464-71 PMID: 2828745 10/01/1987       16 Citations
  • Congenital murine polycystic kidney disease. I. The ontogeny of tubular cyst formation. (Avner ED, Studnicki FE, Young MC, Sweeney WE Jr, Piesco NP, Ellis D, Fettermann GH) Pediatr Nephrol 1987 Oct;1(4):587-96 PMID: 3153336 10/01/1987       42 Citations
  • Triiodothyronine-induced cyst formation in metanephric organ culture: the role of increased Na-K-adenosine triphosphatase activity. (Avner ED, Sweeney WE Jr, Piesco NP, Ellis D) J Lab Clin Med 1987 Apr;109(4):441-53 PMID: 3029256 04/01/1987       12 Citations
  • Silica and glomerulonephritis: case report and review of the literature. (Osorio AM, Thun MJ, Novak RF, Van Cura EJ, Avner ED) Am J Kidney Dis 1987 Mar;9(3):224-30 PMID: 3030097 03/01/1987    
  • Reversible inhibition of cytosolic glucocorticoid receptors by mercurial agents. Application in the measurement of total and unoccupied receptors. (Ellis D, Tran SD, Eagon PK, Avner ED) J Recept Res 1987;7(5):761-74 PMID: 3656273 01/01/1987       1 Citations
  • Renal failure and dialysis therapy in children with hepatic failure in the perioperative period of orthotopic liver transplantation. (Ellis D, Avner ED) Clin Nephrol 1986 Jun;25(6):295-303 PMID: 3524924 06/01/1986       22 Citations
  • Partial characterization and ontogeny of renal cytosolic glucocorticoid receptors in mouse kidney. (Ellis D, Turocy JF, Sweeney WE Jr, Avner ED) J Steroid Biochem 1986 May;24(5):997-1003 PMID: 3724151 05/01/1986       9 Citations
  • Renal failure in children with hepatic failure undergoing liver transplantation. (Ellis D, Avner ED, Starzl TE) J Pediatr 1986 Mar;108(3):393-8 PMID: 3512808 PMCID: PMC2976655 03/01/1986       43 Citations
  • Regression of genetically determined polycystic kidney disease in murine organ culture. (Avner ED, Sweeney WE Jr, Piesco NP, Ellis D) Experientia 1986 Jan 15;42(1):77-80 PMID: 3943602 01/15/1986       11 Citations
  • Effects of improved glycemic control on microalbuminuria in adolescents with insulin-dependent diabetes mellitus. (Ellis D, Avner ED, Kurs-Lasky M, Richards M, Becker DJ) Int J Pediatr Nephrol 1986 Jan-Mar;7(1):31-8 PMID: 3957559 01/01/1986       3 Citations
  • Renal function and somatic growth in pediatric cadaveric renal transplantation with cyclosporine-prednisone immunosuppression. (Ellis D, Avner ED, Rosenthal JT, Taylor RJ, Young LW, Palumbi MA, Hakala TR) Am J Dis Child 1985 Nov;139(11):1161-7 PMID: 3904407 11/01/1985       16 Citations
  • Sodium-potassium ATPase activity mediates cyst formation in metanephric organ culture. (Avner ED, Sweeney WE Jr, Finegold DN, Piesco NP, Ellis D) Kidney Int 1985 Sep;28(3):447-55 PMID: 2999498 09/01/1985    
  • Growth factor requirements of organogenesis in serum-free metanephric organ culture. (Avner ED, Sweeney WE Jr, Piesco NP, Ellis D) In Vitro Cell Dev Biol 1985 May;21(5):297-304 PMID: 3894316 05/01/1985       37 Citations
  • A new model of glucocorticoid-induced metanephric maldevelopment. (Avner ED, Sweeney WE Jr, Piesco NP, Ellis D) Experientia 1984 May 15;40(5):489-90 PMID: 6723915 05/15/1984       13 Citations
  • Hydrocortisone-induced cystic metanephric maldevelopment in serum-free organ culture. (Avner ED, Piesco NP, Sweeney WE Jr, Studnicki FM, Fetterman GH, Ellis D) Lab Invest 1984 Feb;50(2):208-18 PMID: 6694360 02/01/1984       32 Citations
  • Veno-occlusive disease of the liver associated with cysteamine treatment of nephropathic cystinosis. (Avner ED, Ellis D, Jaffe R) J Pediatr 1983 May;102(5):793-6 PMID: 6842343 05/01/1983       35 Citations
  • Diabetic nephropathy in adolescence: appearance during improved glycemic control. (Ellis D, Avner ED, Transue D, Yunis EJ, Drash AL, Becker DJ) Pediatrics 1983 May;71(5):824-9 PMID: 6340051 05/01/1983       16 Citations
  • Single-dose amoxicillin therapy of uncomplicated pediatric urinary tract infections. (Avner ED, Ingelfinger JR, Herrin JT, Link DA, Marcus E, Tolkoff-Rubin NE, Russell-Getz L, Rubin RH) J Pediatr 1983 Apr;102(4):623-7 PMID: 6339708 04/01/1983       28 Citations
  • An organ culture model for the study of metanephric development. (Avner ED, Villee DB, Schneeberger EE, Grupe WE) J Urol 1983 Mar;129(3):660-4 PMID: 6834572 03/01/1983       14 Citations
  • Development of renal basement membrane glycoproteins in metanephric organ culture. (Avner ED, Jaffe R, Temple T, Ellis D, Chung AE) Lab Invest 1983 Mar;48(3):263-8 PMID: 6827806 03/01/1983       25 Citations
  • Cyst formation in metanephric organ culture induced by cis-dichlorodiammineplatinum (II). (Avner ED, Sweeney WE Jr, Ellis D) Experientia 1983 Jan 15;39(1):74-6 PMID: 6681778 01/15/1983       8 Citations
  • Metanephric development in serum-free organ culture. (Avner ED, Ellis D, Temple T, Jaffe R) In Vitro 1982 Aug;18(8):675-82 PMID: 7129481 08/01/1982       50 Citations
  • Neonatal radiocontrast nephropathy simulating infantile polycystic kidney disease. (Avner ED, Ellis D, Jaffe R, Bowen A) J Pediatr 1982 Jan;100(1):85-7 PMID: 7199081 01/01/1982       7 Citations
  • Mortality of chronic hemodialysis and renal transplantation in pediatric end-stage renal disease. (Avner ED, Harmon WE, Grupe WE, Ingelfinger JR, Eraklis AJ, Levey RH) Pediatrics 1981 Mar;67(3):412-6 PMID: 7017579 03/01/1981       18 Citations
  • Mortality of chronic hemodialysis comparable to that of renal transplantation in pediatric end-stage renal disease. (Avner ED, Harmon WE, Ingelfinger JR, Levey RH, Grupe WE) Proc Clin Dial Transplant Forum 1979;9:1-4 PMID: 399499 01/01/1979       2 Citations
  • Letter: Hypoglycorrachia in young infants with viral meningitis. (Avner ED, Satz J, Plotkin SA) J Pediatr 1975 Nov;87(5):833-4 PMID: 1185362 11/01/1975       5 Citations
  • Last update: 01/17/2019
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