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Matthew Budde PhD

Matthew Budde PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Neurosurgery
Division: Research
Program: Clinical Research

Member of the Cancer Center
Member of the Neuroscience Research Center


Research Experience

  • Brain Concussion
  • Brain Injuries
  • Diffuse Axonal Injury
  • Diffusion Magnetic Resonance Imaging
  • Disease Models, Animal
  • Histology
  • Hypoxia-Ischemia, Brain
  • Magnetic Resonance Imaging
  • Microscopy
  • Multiple Sclerosis
  • Neurosciences
  • Spinal Cord Injuries
  • Diffusion Tensor Imaging
  • MCW Program / Core Facilities

  • Center for Imaging Research
  • Neuroscience Research Center
  • Publications (59)

  • Comparison between quantitative measurements of diffusion tensor imaging and T2 signal intensity in a large series of cervical spondylotic myelopathy patients for assessment of disease severity and prognostication of recovery. (Shabani S, Kaushal M, Budde M, Schmit B, Wang MC, Kurpad S) J Neurosurg Spine 2019 Jun 07:1-7 PMID: 31174184 SCOPUS ID: 2-s2.0-85072775711 06/08/2019    
  • In vivo high-resolution diffusion tensor imaging of the developing neonatal rat cortex and its relationship to glial and dendritic maturation. (Breu M, Reisinger D, Tao L, Wu D, Zhang Y, Budde MD, Fatemi A, Pathak AP, Zhang J) Brain Struct Funct 2019 Jun;224(5):1815-1829 PMID: 31011813 PMCID: PMC6565480 SCOPUS ID: 2-s2.0-85064609350 04/24/2019    
  • Diffusion Tensor Imaging in Acute Spinal Cord Injury: A Review of Animal and Human Studies. (Kaushal M, Shabani S, Budde M, Kurpad S) J Neurotrauma 2019 Aug 01;36(15):2279-2286 PMID: 30950317 SCOPUS ID: 2-s2.0-85071059121 04/06/2019    
  • Correlation of magnetic resonance diffusion tensor imaging parameters with American Spinal Injury Association score for prognostication and long-term outcomes. (Shabani S, Kaushal M, Budde M, Kurpad SN) Neurosurg Focus 2019 03 01;46(3):E2 PMID: 30835673 SCOPUS ID: 2-s2.0-85062643112 03/06/2019    
  • Repeated blast model of mild traumatic brain injury alters oxycodone self-administration and drug seeking. (Nawarawong NN, Slaker M, Muelbl M, Shah AS, Chiariello R, Nelson LD, Budde MD, Stemper BD, Olsen CM) Eur J Neurosci 2019 Aug;50(3):2101-2112 PMID: 30456793 PMCID: PMC6814147 SCOPUS ID: 2-s2.0-85058419226 11/21/2018       2 Citations
  • Longitudinal Diffusion Magnetic Resonance Imaging Remote from the Lesion Site in Rat Spinal Cord Injury. (Motovylyak A, Skinner NP, Schmit BD, Wilkins N, Kurpad SN, Budde MD) J Neurotrauma 2019 May 01;36(9):1389-1398 PMID: 30259800 PMCID: PMC6482909 SCOPUS ID: 2-s2.0-85065073949 09/28/2018       1 Citation
  • Effects of Mild Blast Traumatic Brain Injury on Cognitive- and Addiction-Related Behaviors. (Muelbl MJ, Slaker ML, Shah AS, Nawarawong NN, Gerndt CH, Budde MD, Stemper BD, Olsen CM) Sci Rep 2018 07 02;8(1):9941 PMID: 29967344 PMCID: PMC6028456 SCOPUS ID: 2-s2.0-85049369592 07/04/2018       4 Citations
  • Diffusion MRI in acute nervous system injury. (Budde MD, Skinner NP) J Magn Reson 2018 07;292:137-148 PMID: 29773299 SCOPUS ID: 2-s2.0-85047209748 05/19/2018       4 Citations
  • Design and validation of diffusion MRI models of white matter. (Jelescu IO, Budde MD) Front Phys 2017 11;28 PMID: 29755979 PMCID: PMC5947881 05/15/2018    
  • Filter-probe diffusion imaging improves spinal cord injury outcome prediction. (Skinner NP, Lee SY, Kurpad SN, Schmit BD, Muftuler LT, Budde MD) Ann Neurol 2018 07;84(1):37-50 PMID: 29752739 PMCID: PMC6119508 SCOPUS ID: 2-s2.0-85050866980 05/13/2018       2 Citations
  • Diffusion Tensor Imaging in a Large Longitudinal Series of Patients With Cervical Spondylotic Myelopathy Correlated With Long-Term Functional Outcome. (Rao A, Soliman H, Kaushal M, Motovylyak O, Vedantam A, Budde MD, Schmit B, Wang M, Kurpad SN) Neurosurgery 2018 10 01;83(4):753-760 PMID: 29529304 SCOPUS ID: 2-s2.0-85068819376 03/13/2018       6 Citations
  • Optimizing Filter-Probe Diffusion Weighting in the Rat Spinal Cord for Human Translation. (Budde MD, Skinner NP, Muftuler LT, Schmit BD, Kurpad SN) Front Neurosci 2017;11:706 PMID: 29311786 PMCID: PMC5742102 01/10/2018    
  • Imaging Evaluation of Degenerative Cervical Myelopathy: Current State of the Art and Future Directions. (Martin AR, Tadokoro N, Tetreault L, Arocho-Quinones EV, Budde MD, Kurpad SN, Fehlings MG) Neurosurg Clin N Am 2018 Jan;29(1):33-45 PMID: 29173434 SCOPUS ID: 2-s2.0-85034997034 11/28/2017       5 Citations
  • Large-Scale Network Analysis of Whole-Brain Resting-State Functional Connectivity in Spinal Cord Injury: A Comparative Study. (Kaushal M, Oni-Orisan A, Chen G, Li W, Leschke J, Ward D, Kalinosky B, Budde M, Schmit B, Li SJ, Muqeet V, Kurpad S) Brain Connect 2017 09;7(7):413-423 PMID: 28657334 SCOPUS ID: 2-s2.0-85043318892 06/29/2017       2 Citations
  • Evaluation of Whole-Brain Resting-State Functional Connectivity in Spinal Cord Injury: A Large-Scale Network Analysis Using Network-Based Statistic. (Kaushal M, Oni-Orisan A, Chen G, Li W, Leschke J, Ward BD, Kalinosky B, Budde MD, Schmit BD, Li SJ, Muqeet V, Kurpad SN) J Neurotrauma 2017 03 15;34(6):1278-1282 PMID: 27937140 SCOPUS ID: 2-s2.0-85015212841 12/13/2016       13 Citations
  • Prediction of Post-Concussive Behavioral Changes in a Rodent Model Based on Head Rotational Acceleration Characteristics. (Stemper BD, Shah AS, Chiariello R, Olsen CM, Budde MD, Glavaski-Joksimovic A, McCrea M, Kurpad SN, Pintar FA) Ann Biomed Eng 2016 Nov;44(11):3252-3265 PMID: 27188340 PMCID: PMC5093216 SCOPUS ID: 2-s2.0-84969253175 11/04/2016       3 Citations
  • Rapid in vivo detection of rat spinal cord injury with double-diffusion-encoded magnetic resonance spectroscopy. (Skinner NP, Kurpad SN, Schmit BD, Tugan Muftuler L, Budde MD) Magn Reson Med 2017 04;77(4):1639-1649 PMID: 27080726 PMCID: PMC5285487 SCOPUS ID: 2-s2.0-84963629087 04/16/2016       18 Citations
  • Behavioral Outcomes Differ between Rotational Acceleration and Blast Mechanisms of Mild Traumatic Brain Injury. (Stemper BD, Shah AS, Budde MD, Olsen CM, Glavaski-Joksimovic A, Kurpad SN, McCrea M, Pintar FA) Front Neurol 2016;7:31 PMID: 27014184 PMCID: PMC4789366 03/26/2016    
  • Alterations in Cortical Sensorimotor Connectivity following Complete Cervical Spinal Cord Injury: A Prospective Resting-State fMRI Study. (Oni-Orisan A, Kaushal M, Li W, Leschke J, Ward BD, Vedantam A, Kalinosky B, Budde MD, Schmit BD, Li SJ, Muqeet V, Kurpad SN) PLoS One 2016;11(3):e0150351 PMID: 26954693 PMCID: PMC4783046 SCOPUS ID: 2-s2.0-84962600492 03/10/2016       19 Citations
  • Detection of acute nervous system injury with advanced diffusion-weighted MRI: a simulation and sensitivity analysis. (Skinner NP, Kurpad SN, Schmit BD, Budde MD) NMR Biomed 2015 Nov;28(11):1489-506 PMID: 26411743 SCOPUS ID: 2-s2.0-84945471406 09/29/2015       13 Citations
  • Reduction of Diffusion-Weighted Imaging Contrast of Acute Ischemic Stroke at Short Diffusion Times. (Baron CA, Kate M, Gioia L, Butcher K, Emery D, Budde M, Beaulieu C) Stroke 2015 Aug;46(8):2136-41 PMID: 26152297 SCOPUS ID: 2-s2.0-84944707435 07/15/2015       22 Citations
  • Severity of spinal cord injury influences diffusion tensor imaging of the brain. (Jirjis MB, Vedantam A, Budde MD, Kalinosky B, Kurpad SN, Schmit BD) J Magn Reson Imaging 2016 Jan;43(1):63-74 PMID: 26094789 SCOPUS ID: 2-s2.0-84955640260 06/23/2015       5 Citations
  • Failure of intravenous or intracardiac delivery of mesenchymal stromal cells to improve outcomes after focal traumatic brain injury in the female rat. (Turtzo LC, Budde MD, Dean DD, Gold EM, Lewis BK, Janes L, Lescher J, Coppola T, Yarnell A, Grunberg NE, Frank JA) PLoS One 2015;10(5):e0126551 PMID: 25946089 PMCID: PMC4422703 SCOPUS ID: 2-s2.0-84929105130 05/07/2015       7 Citations
  • Diffusion imaging in the rat cervical spinal cord. (Zakszewski E, Schmit B, Kurpad S, Budde MD) J Vis Exp 2015 Apr 07(98) PMID: 25938297 PMCID: PMC4541495 SCOPUS ID: 2-s2.0-84941243009 05/06/2015       4 Citations
  • Voluntary Alcohol Intake following Blast Exposure in a Rat Model of Mild Traumatic Brain Injury. (Lim YW, Meyer NP, Shah AS, Budde MD, Stemper BD, Olsen CM) PLoS One 2015;10(4):e0125130 PMID: 25910266 PMCID: PMC4409117 SCOPUS ID: 2-s2.0-84929322542 04/25/2015       16 Citations
  • Effects of blast overpressure on neurons and glial cells in rat organotypic hippocampal slice cultures. (Miller AP, Shah AS, Aperi BV, Budde MD, Pintar FA, Tarima S, Kurpad SN, Stemper BD, Glavaski-Joksimovic A) Front Neurol 2015;6:20 PMID: 25729377 PMCID: PMC4325926 03/03/2015    
  • Characterization of differing time-course of cognitive deficits and emotional changes following rotational traumatic brain injury in the rat (Stemper BD, Shah AS, Budde MD, Chiariello R, Wilkins N, Olsen C, Mehta P, Kurpad SN, McCrea M, Pintar FA) 2015 IRCOBI Conference Proceedings - International Research Council on the Biomechanics of Injury 2015:198-207 SCOPUS ID: 2-s2.0-84996866475 01/01/2015    
  • Head rotational acceleration characteristics influence behavioral and diffusion tensor imaging outcomes following concussion. (Stemper BD, Shah AS, Pintar FA, McCrea M, Kurpad SN, Glavaski-Joksimovic A, Olsen C, Budde MD) Ann Biomed Eng 2015 May;43(5):1071-88 PMID: 25344352 PMCID: PMC4654450 SCOPUS ID: 2-s2.0-84940004699 10/26/2014       33 Citations
  • Phase-aligned multiple spin-echo averaging: a simple way to improve signal-to-noise ratio of in vivo mouse spinal cord diffusion tensor image. (Tu TW, Budde MD, Xie M, Chen YJ, Wang Q, Quirk JD, Song SK) Magn Reson Imaging 2014 Dec;32(10):1335-43 PMID: 25087856 PMCID: PMC4252722 SCOPUS ID: 2-s2.0-84961318352 08/05/2014       6 Citations
  • Diffusion tensor imaging reveals acute subcortical changes after mild blast-induced traumatic brain injury. (Kamnaksh A, Budde MD, Kovesdi E, Long JB, Frank JA, Agoston DV) Sci Rep 2014 May 02;4:4809 PMID: 24786839 PMCID: PMC4019232 SCOPUS ID: 2-s2.0-84899864979 05/03/2014       23 Citations
  • Macrophagic and microglial responses after focal traumatic brain injury in the female rat. (Turtzo LC, Lescher J, Janes L, Dean DD, Budde MD, Frank JA) J Neuroinflammation 2014 Apr 24;11:82 PMID: 24761998 PMCID: PMC4022366 SCOPUS ID: 2-s2.0-84899953493 04/26/2014       79 Citations
  • Preclinical anatomical, molecular, and functional imaging of the lung with multiple modalities. (Gammon ST, Foje N, Brewer EM, Owers E, Downs CA, Budde MD, Leevy WM, Helms MN) Am J Physiol Lung Cell Mol Physiol 2014 May 15;306(10):L897-914 PMID: 24658139 SCOPUS ID: 2-s2.0-84900823117 03/25/2014       20 Citations
  • Effects of the coexistence of late-life depression and mild cognitive impairment on white matter microstructure. (Li W, Muftuler LT, Chen G, Ward BD, Budde MD, Jones JL, Franczak MB, Antuono PG, Li SJ, Goveas JS) J Neurol Sci 2014 Mar 15;338(1-2):46-56 PMID: 24387897 PMCID: PMC4428544 SCOPUS ID: 2-s2.0-84896714136 01/07/2014       20 Citations
  • Primary blast traumatic brain injury in the rat: relating diffusion tensor imaging and behavior. (Budde MD, Shah A, McCrea M, Cullinan WE, Pintar FA, Stemper BD) Front Neurol 2013;4:154 PMID: 24133481 PMCID: PMC3796287 10/18/2013    
  • Diffusion MRI of the developing cerebral cortical gray matter can be used to detect abnormalities in tissue microstructure associated with fetal ethanol exposure. (Leigland LA, Budde MD, Cornea A, Kroenke CD) Neuroimage 2013 Dec;83:1081-7 PMID: 23921100 PMCID: PMC3815979 SCOPUS ID: 2-s2.0-84886412536 08/08/2013       19 Citations
  • Microstructural organization of axons in the human corpus callosum quantified by diffusion-weighted magnetic resonance spectroscopy of N-acetylaspartate and post-mortem histology. (Ronen I, Budde M, Ercan E, Annese J, Techawiboonwong A, Webb A) Brain Struct Funct 2014 Sep;219(5):1773-85 PMID: 23794120 SCOPUS ID: 2-s2.0-85027921911 06/25/2013       51 Citations
  • Quantification of anisotropy and fiber orientation in human brain histological sections. (Budde MD, Annese J) Front Integr Neurosci 2013;7:3 PMID: 23378830 PMCID: PMC3561729 02/05/2013    
  • The evolution of traumatic brain injury in a rat focal contusion model. (Turtzo LC, Budde MD, Gold EM, Lewis BK, Janes L, Yarnell A, Grunberg NE, Watson W, Frank JA) NMR Biomed 2013 Apr;26(4):468-79 PMID: 23225324 PMCID: PMC3596464 SCOPUS ID: 2-s2.0-84875054190 12/12/2012       16 Citations
  • Diffusion tensor imaging and tractography in Brown-Sequard syndrome. (Vedantam A, Jirjis MB, Schmit BD, Budde MD, Ulmer JL, Wang MC, Kurpad SN) Spinal Cord 2012 Dec;50(12):928-30 PMID: 23045298 SCOPUS ID: 2-s2.0-84870952535 10/10/2012       8 Citations
  • Examining brain microstructure using structure tensor analysis of histological sections. (Budde MD, Frank JA) Neuroimage 2012 Oct 15;63(1):1-10 PMID: 22759994 SCOPUS ID: 2-s2.0-84864039331 07/05/2012       83 Citations
  • Self-assembling nanocomplexes by combining ferumoxytol, heparin and protamine for cell tracking by magnetic resonance imaging. (Thu MS, Bryant LH, Coppola T, Jordan EK, Budde MD, Lewis BK, Chaudhry A, Ren J, Varma NR, Arbab AS, Frank JA) Nat Med 2012 Feb 26;18(3):463-7 PMID: 22366951 PMCID: PMC3296876 SCOPUS ID: 2-s2.0-84858004983 03/01/2012       126 Citations
  • Differential microstructure and physiology of brain and bone metastases in a rat breast cancer model by diffusion and dynamic contrast enhanced MRI. (Budde MD, Gold E, Jordan EK, Frank JA) Clin Exp Metastasis 2012 Jan;29(1):51-62 PMID: 22042553 PMCID: PMC3233647 SCOPUS ID: 2-s2.0-84856015107 11/02/2011       21 Citations
  • Phase contrast MRI is an early marker of micrometastatic breast cancer development in the rat brain. (Budde MD, Gold E, Jordan EK, Smith-Brown M, Frank JA) NMR Biomed 2012 May;25(5):726-36 PMID: 21954124 PMCID: PMC3252479 SCOPUS ID: 2-s2.0-84859644696 09/29/2011       10 Citations
  • The contribution of gliosis to diffusion tensor anisotropy and tractography following traumatic brain injury: validation in the rat using Fourier analysis of stained tissue sections. (Budde MD, Janes L, Gold E, Turtzo LC, Frank JA) Brain 2011 Aug;134(Pt 8):2248-60 PMID: 21764818 PMCID: PMC3155707 07/19/2011    
  • Noninvasive detection of brainstem and spinal cord axonal degeneration in an amyotrophic lateral sclerosis mouse model. (Kim JH, Wu TH, Budde MD, Lee JM, Song SK) NMR Biomed 2011 Feb;24(2):163-9 PMID: 21344532 PMCID: PMC5180599 SCOPUS ID: 2-s2.0-79951839343 02/24/2011       19 Citations
  • Radial diffusivity predicts demyelination in ex vivo multiple sclerosis spinal cords. (Klawiter EC, Schmidt RE, Trinkaus K, Liang HF, Budde MD, Naismith RT, Song SK, Cross AH, Benzinger TL) Neuroimage 2011 Apr 15;55(4):1454-60 PMID: 21238597 PMCID: PMC3062747 SCOPUS ID: 2-s2.0-79952735821 01/18/2011       212 Citations
  • Neurite beading is sufficient to decrease the apparent diffusion coefficient after ischemic stroke. (Budde MD, Frank JA) Proc Natl Acad Sci U S A 2010 Aug 10;107(32):14472-7 PMID: 20660718 PMCID: PMC2922529 SCOPUS ID: 2-s2.0-77956295704 07/28/2010       115 Citations
  • Rostrocaudal analysis of corpus callosum demyelination and axon damage across disease stages refines diffusion tensor imaging correlations with pathological features. (Xie M, Tobin JE, Budde MD, Chen CI, Trinkaus K, Cross AH, McDaniel DP, Song SK, Armstrong RC) J Neuropathol Exp Neurol 2010 Jul;69(7):704-16 PMID: 20535036 PMCID: PMC2901930 SCOPUS ID: 2-s2.0-77954732542 06/11/2010       103 Citations
  • Diffusion tensor imaging at 3 hours after traumatic spinal cord injury predicts long-term locomotor recovery. (Kim JH, Loy DN, Wang Q, Budde MD, Schmidt RE, Trinkaus K, Song SK) J Neurotrauma 2010 Mar;27(3):587-98 PMID: 20001686 PMCID: PMC2867549 SCOPUS ID: 2-s2.0-77950612951 12/17/2009       82 Citations
  • IL-1R signaling within the central nervous system regulates CXCL12 expression at the blood-brain barrier and disease severity during experimental autoimmune encephalomyelitis. (McCandless EE, Budde M, Lees JR, Dorsey D, Lyng E, Klein RS) J Immunol 2009 Jul 01;183(1):613-20 PMID: 19535637 PMCID: PMC2892701 SCOPUS ID: 2-s2.0-68949119874 06/19/2009       58 Citations
  • Axial diffusivity is the primary correlate of axonal injury in the experimental autoimmune encephalomyelitis spinal cord: a quantitative pixelwise analysis. (Budde MD, Xie M, Cross AH, Song SK) J Neurosci 2009 Mar 04;29(9):2805-13 PMID: 19261876 PMCID: PMC2673458 SCOPUS ID: 2-s2.0-63849246613 03/06/2009       309 Citations
  • Magnetic tagging of therapeutic cells for MRI. (Budde MD, Frank JA) J Nucl Med 2009 Feb;50(2):171-4 PMID: 19164242 PMCID: PMC2633027 SCOPUS ID: 2-s2.0-59249103743 01/24/2009       58 Citations
  • Axonal injury detected by in vivo diffusion tensor imaging correlates with neurological disability in a mouse model of multiple sclerosis. (Budde MD, Kim JH, Liang HF, Russell JH, Cross AH, Song SK) NMR Biomed 2008 Jul;21(6):589-97 PMID: 18041806 PMCID: PMC2602834 SCOPUS ID: 2-s2.0-48349129527 11/29/2007       137 Citations
  • High-resolution MR metabolic imaging. (Haldar JP, Hernando D, Budde MD, Wang Q, Song SK, Liang ZP) Conf Proc IEEE Eng Med Biol Soc 2007;2007:4324-6 PMID: 18002959 SCOPUS ID: 2-s2.0-57649205751 11/16/2007       3 Citations
  • Postmortem delay does not change regional diffusion anisotropy characteristics in mouse spinal cord white matter. (Kim JH, Trinkaus K, Ozcan A, Budde MD, Song SK) NMR Biomed 2007 May;20(3):352-9 PMID: 17451177 SCOPUS ID: 2-s2.0-34249668795 04/25/2007       28 Citations
  • Toward accurate diagnosis of white matter pathology using diffusion tensor imaging. (Budde MD, Kim JH, Liang HF, Schmidt RE, Russell JH, Cross AH, Song SK) Magn Reson Med 2007 Apr;57(4):688-95 PMID: 17390365 SCOPUS ID: 2-s2.0-34248356267 03/29/2007       282 Citations
  • Detecting axon damage in spinal cord from a mouse model of multiple sclerosis. (Kim JH, Budde MD, Liang HF, Klein RS, Russell JH, Cross AH, Song SK) Neurobiol Dis 2006 Mar;21(3):626-32 PMID: 16298135 SCOPUS ID: 2-s2.0-33244488050 11/22/2005       191 Citations
  • Brain activity during episodic retrieval of autobiographical and laboratory events: an fMRI study using a novel photo paradigm. (Cabeza R, Prince SE, Daselaar SM, Greenberg DL, Budde M, Dolcos F, LaBar KS, Rubin DC) J Cogn Neurosci 2004 Nov;16(9):1583-94 PMID: 15622612 SCOPUS ID: 2-s2.0-4344645804 12/30/2004       236 Citations
  • Task-independent and task-specific age effects on brain activity during working memory, visual attention and episodic retrieval. (Cabeza R, Daselaar SM, Dolcos F, Prince SE, Budde M, Nyberg L) Cereb Cortex 2004 Apr;14(4):364-75 PMID: 15028641 SCOPUS ID: 2-s2.0-1942486433 03/19/2004       523 Citations
  • Last update: 10/02/2019
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