Medical College of Wisconsin
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Antje Kroner-Milsch MD, PhD

Antje Kroner-Milsch MD, PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Neurosurgery
Division: Research
Program: Clinical Research


Research Experience

  • Neurosciences
  • Spinal Cord Injuries
  • Methodologies and Techniques

  • Flow Cytometry
  • Histology
  • Spinal Cord Injuries
  • Publications

  • Small-Molecule Stabilization of 14-3-3 Protein-Protein Interactions Stimulates Axon Regeneration. (Kaplan A, Morquette B, Kroner A, Leong S, Madwar C, Sanz R, Banerjee SL, Antel J, Bisson N, David S, Fournier AE) Neuron 2017 Mar 08;93(5):1082-1093.e5 PMID: 28279353 03/11/2017
  • Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients. (Sadovnick AD, Traboulsee AL, Bernales CQ, Ross JP, Forwell AL, Yee IM, Guillot-Noel L, Fontaine B, Cournu-Rebeix I, Alcina A, Fedetz M, Izquierdo G, Matesanz F, Hilven K, Dubois B, Goris A, Astobiza I, Alloza I, Antigüedad A, Vandenbroeck K, Akkad DA, Aktas O, Blaschke P, Buttmann M, Chan A, Epplen JT, Gerdes LA, Kroner A, Kubisch C, Kümpfel T, Lohse P, Rieckmann P, Zettl UK, Zipp F, Bertram L, Lill CM, Fernandez O, Urbaneja P, Leyva L, Alvarez-Cermeño JC, Arroyo R, Garagorri AM, García-Martínez A, Villar LM, Urcelay E, Malhotra S, Montalban X, Comabella M, Berger T, Fazekas F, Reindl M, Schmied MC, Zimprich A, Vilariño-Güell C) G3 (Bethesda) 2016 Jul 07;6(7):2073-9 PMID: 27194806 PMCID: PMC4938660 05/20/2016
  • Arginase-1 is expressed exclusively by infiltrating myeloid cells in CNS injury and disease. (Greenhalgh AD, Passos Dos Santos R, Zarruk JG, Salmon CK, Kroner A, David S) Brain Behav Immun 2016 Aug;56:61-7 PMID: 27126514 04/30/2016
  • Role of IL-10 in Resolution of Inflammation and Functional Recovery after Peripheral Nerve Injury. (Siqueira Mietto B, Kroner A, Girolami EI, Santos-Nogueira E, Zhang J, David S) J Neurosci 2015 Dec 16;35(50):16431-42 PMID: 26674868 12/18/2015
  • Investigation of sex-specific effects of apolipoprotein E on severity of EAE and MS. (Schrewe L, Lill CM, Liu T, Salmen A, Gerdes LA, Guillot-Noel L, Akkad DA, Blaschke P, Graetz C, Hoffjan S, Kroner A, Demir S, Böhme A, Rieckmann P, ElAli A, Hagemann N, Hermann DM, Cournu-Rebeix I, Zipp F, Kümpfel T, Buttmann M, Zettl UK, Fontaine B, Bertram L, Gold R, Chan A) J Neuroinflammation 2015 Dec 16;12:234 PMID: 26669675 PMCID: PMC4681148 12/17/2015
  • Genome-wide significant association with seven novel multiple sclerosis risk loci. (Lill CM, Luessi F, Alcina A, Sokolova EA, Ugidos N, de la Hera B, Guillot-Noël L, Malhotra S, Reinthaler E, Schjeide BM, Mescheriakova JY, Mashychev A, Wohlers I, Akkad DA, Aktas O, Alloza I, Antigüedad A, Arroyo R, Astobiza I, Blaschke P, Boyko AN, Buttmann M, Chan A, Dörner T, Epplen JT, Favorova OO, Fedetz M, Fernández O, García-Martínez A, Gerdes LA, Graetz C, Hartung HP, Hoffjan S, Izquierdo G, Korobko DS, Kroner A, Kubisch C, Kümpfel T, Leyva L, Lohse P, Malkova NA, Montalban X, Popova EV, Rieckmann P, Rozhdestvenskii AS, Schmied C, Smagina IV, Tsareva EY, Winkelmann A, Zettl UK, Binder H, Cournu-Rebeix I, Hintzen R, Zimprich A, Comabella M, Fontaine B, Urcelay E, Vandenbroeck K, Filipenko M, Matesanz F, Zipp F, Bertram L) J Med Genet 2015 Dec;52(12):848-55 PMID: 26475045 10/18/2015
  • Macrophage and microglial plasticity in the injured spinal cord. (David S, Greenhalgh AD, Kroner A) Neuroscience 2015 Oct 29;307:311-8 PMID: 26342747 09/08/2015
  • Expression of iron homeostasis proteins in the spinal cord in experimental autoimmune encephalomyelitis and their implications for iron accumulation. (Zarruk JG, Berard JL, Passos dos Santos R, Kroner A, Lee J, Arosio P, David S) Neurobiol Dis 2015 Sep;81:93-107 PMID: 25724358 03/01/2015
  • TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord. (Kroner A, Greenhalgh AD, Zarruk JG, Passos Dos Santos R, Gaestel M, David S) Neuron 2014 Sep 03;83(5):1098-116 PMID: 25132469 08/19/2014
  • Assessment of microRNA-related SNP effects in the 3' untranslated region of the IL22RA2 risk locus in multiple sclerosis. (Lill CM, Schilling M, Ansaloni S, Schröder J, Jaedicke M, Luessi F, Schjeide BM, Mashychev A, Graetz C, Akkad DA, Gerdes LA, Kroner A, Blaschke P, Hoffjan S, Winkelmann A, Dörner T, Rieckmann P, Steinhagen-Thiessen E, Lindenberger U, Chan A, Hartung HP, Aktas O, Lohse P, Buttmann M, Kümpfel T, Kubisch C, Zettl UK, Epplen JT, Zipp F, Bertram L) Neurogenetics 2014 May;15(2):129-34 PMID: 24638856 03/19/2014
  • MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis. (International Multiple Sclerosis Genetics Consortium, Lill CM, Schjeide BM, Graetz C, Ban M, Alcina A, Ortiz MA, Pérez J, Damotte V, Booth D, Lopez de Lapuente A, Broer L, Schilling M, Akkad DA, Aktas O, Alloza I, Antigüedad A, Arroyo R, Blaschke P, Buttmann M, Chan A, Compston A, Cournu-Rebeix I, Dörner T, Epplen JT, Fernández Ó, Gerdes LA, Guillot-Noël L, Hartung HP, Hoffjan S, Izquierdo G, Kemppinen A, Kroner A, Kubisch C, Kümpfel T, Li SC, Lindenberger U, Lohse P, Lubetzki C, Luessi F, Malhotra S, Mescheriakova J, Montalban X, Papeix C, Paredes LF, Rieckmann P, Steinhagen-Thiessen E, Winkelmann A, Zettl UK, Hintzen R, Vandenbroeck K, Stewart G, Fontaine B, Comabella M, Urcelay E, Matesanz F, Sawcer S, Bertram L, Zipp F) Brain 2013 Jun;136(Pt 6):1778-82 PMID: 23739915 PMCID: PMC3673463 06/07/2013
  • Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouse. (Ip CW, Kroner A, Groh J, Huber M, Klein D, Spahn I, Diem R, Williams SK, Nave KA, Edgar JM, Martini R) PLoS One 2012;7(8):e42554 PMID: 22905147 PMCID: PMC3414455 08/21/2012
  • Iron efflux from astrocytes plays a role in remyelination. (Schulz K, Kroner A, David S) J Neurosci 2012 Apr 04;32(14):4841-7 PMID: 22492039 04/12/2012
  • Repertoire of microglial and macrophage responses after spinal cord injury. (David S, Kroner A) Nat Rev Neurosci 2011 Jun 15;12(7):388-99 PMID: 21673720 06/16/2011
  • More CLEC16A gene variants associated with multiple sclerosis. (Nischwitz S, Cepok S, Kroner A, Wolf C, Knop M, Müller-Sarnowski F, Pfister H, Rieckmann P, Hemmer B, Ising M, Uhr M, Bettecken T, Holsboer F, Müller-Myhsok B, Weber F) Acta Neurol Scand 2011 Jun;123(6):400-6 PMID: 20849399 09/21/2010
  • Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis. (Nischwitz S, Cepok S, Kroner A, Wolf C, Knop M, Müller-Sarnowski F, Pfister H, Roeske D, Rieckmann P, Hemmer B, Ising M, Uhr M, Bettecken T, Holsboer F, Müller-Myhsok B, Weber F) J Neuroimmunol 2010 Oct 08;227(1-2):162-6 PMID: 20598377 07/06/2010
  • Lack of evidence for a pathogenic role of T-lymphocytes in an animal model for Charcot-Marie-Tooth disease 1A. (Kohl B, Groh J, Wessig C, Wiendl H, Kroner A, Martini R) Neurobiol Dis 2010 Apr;38(1):78-84 PMID: 20064611 01/13/2010
  • Ectopic T-cell specificity and absence of perforin and granzyme B alleviate neural damage in oligodendrocyte mutant mice. (Kroner A, Ip CW, Thalhammer J, Nave KA, Martini R) Am J Pathol 2010 Feb;176(2):549-55 PMID: 20042681 PMCID: PMC2808063 01/01/2010
  • Accelerated course of experimental autoimmune encephalomyelitis in PD-1-deficient central nervous system myelin mutants. (Kroner A, Schwab N, Ip CW, Ortler S, Göbel K, Nave KA, Mäurer M, Martini R, Wiendl H) Am J Pathol 2009 Jun;174(6):2290-9 PMID: 19443704 PMCID: PMC2684193 05/16/2009
  • PD-1 regulates neural damage in oligodendroglia-induced inflammation. (Kroner A, Schwab N, Ip CW, Leder C, Nave KA, Mäurer M, Wiendl H, Martini R) PLoS One 2009;4(2):e4405 PMID: 19197390 PMCID: PMC2635015 02/07/2009
  • Tacrolimus (FK506) causes disease aggravation in models for inherited peripheral myelinopathies. (Ip CW, Kroner A, Kohl B, Wessig C, Martini R) Neurobiol Dis 2009 Feb;33(2):207-12 PMID: 19028581 11/26/2008
  • Analysis of the stathmin rs182455 single nucleotide promoter polymorphism in patients with multiple sclerosis. (Buttmann M, Nowak E, Kroner A, Hemmer B, Lesch KP, Rieckmann P) J Neurogenet 2008;22(3):181-6 PMID: 19012073 11/18/2008
  • The co-inhibitory molecule PD-1 modulates disease severity in a model for an inherited, demyelinating neuropathy. (Kroner A, Schwab N, Ip CW, Sommer C, Wessig C, Wiendl H, Martini R) Neurobiol Dis 2009 Jan;33(1):96-103 PMID: 18996482 11/11/2008
  • Refining genetic associations in multiple sclerosis. (International Multiple Sclerosis Genetics Consortium (IMSGC)) Lancet Neurol 2008 Jul;7(7):567-9 PMID: 18565446 PMCID: PMC2696028 06/21/2008
  • Origin of CD11b+ macrophage-like cells in the CNS of PLP-overexpressing mice: low influx of haematogenous macrophages and unchanged blood-brain-barrier in the optic nerve. (Ip CW, Kohl B, Kleinschnitz C, Reuss B, Nave KA, Kroner A, Martini R) Mol Cell Neurosci 2008 Aug;38(4):489-94 PMID: 18555697 06/17/2008
  • B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: implications for the lesion pathogenesis of multiple sclerosis. (Ortler S, Leder C, Mittelbronn M, Zozulya AL, Knolle PA, Chen L, Kroner A, Wiendl H) Eur J Immunol 2008 Jun;38(6):1734-44 PMID: 18421793 04/19/2008
  • IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations. (Weber F, Fontaine B, Cournu-Rebeix I, Kroner A, Knop M, Lutz S, Müller-Sarnowski F, Uhr M, Bettecken T, Kohli M, Ripke S, Ising M, Rieckmann P, Brassat D, Semana G, Babron MC, Mrejen S, Gout C, Lyon-Caen O, Yaouanq J, Edan G, Clanet M, Holsboer F, Clerget-Darpoux F, Müller-Myhsok B) Genes Immun 2008 Apr;9(3):259-63 PMID: 18354419 03/21/2008
  • mtDNA nt13708A variant increases the risk of multiple sclerosis. (Yu X, Koczan D, Sulonen AM, Akkad DA, Kroner A, Comabella M, Costa G, Corongiu D, Goertsches R, Camina-Tato M, Thiesen HJ, Nyland HI, Mørk SJ, Montalban X, Rieckmann P, Marrosu MG, Myhr KM, Epplen JT, Saarela J, Ibrahim SM) PLoS One 2008 Feb 13;3(2):e1530 PMID: 18270557 PMCID: PMC2217590 02/14/2008
  • Clonal expansions of pathogenic CD8+ effector cells in the CNS of myelin mutant mice. (Leder C, Schwab N, Ip CW, Kroner A, Nave KA, Dornmair K, Martini R, Wiendl H) Mol Cell Neurosci 2007 Nov;36(3):416-24 PMID: 17889554 09/25/2007
  • The genetic influence of the nonclassical MHC molecule HLA-G on multiple sclerosis. (Kroner A, Grimm A, Johannssen K, Mäurer M, Wiendl H) Hum Immunol 2007 May;68(5):422-5 PMID: 17462509 04/28/2007
  • Visualization of degenerating axons in a dysmyelinating mouse mutant with axonal loss. (Ey B, Kobsar I, Blazyca H, Kroner A, Martini R) Mol Cell Neurosci 2007 May;35(1):153-60 PMID: 17383197 03/27/2007
  • Sialoadhesin deficiency ameliorates myelin degeneration and axonopathic changes in the CNS of PLP overexpressing mice. (Ip CW, Kroner A, Crocker PR, Nave KA, Martini R) Neurobiol Dis 2007 Jan;25(1):105-11 PMID: 17064921 10/27/2006
  • Analysis of the C/T(-1) single nucleotide polymorphism in the CD40 gene in multiple sclerosis. (Buck D, Kroner A, Rieckmann P, Mäurer M, Wiendl H) Tissue Antigens 2006 Oct;68(4):335-8 PMID: 17026470 10/10/2006
  • Frequency analysis of HLA-B7-restricted Epstein-Barr virus-specific cytotoxic T lymphocytes in patients with multiple sclerosis and healthy controls. (Gronen F, Ruprecht K, Weissbrich B, Klinker E, Kroner A, Hofstetter HH, Rieckmann P) J Neuroimmunol 2006 Nov;180(1-2):185-92 PMID: 17023054 10/07/2006
  • Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytes. (Ip CW, Kroner A, Bendszus M, Leder C, Kobsar I, Fischer S, Wiendl H, Nave KA, Martini R) J Neurosci 2006 Aug 02;26(31):8206-16 PMID: 16885234 08/04/2006
  • The role of leukemia-derived B7-H1 (PD-L1) in tumor-T-cell interactions in humans. (Salih HR, Wintterle S, Krusch M, Kroner A, Huang YH, Chen L, Wiendl H) Exp Hematol 2006 Jul;34(7):888-94 PMID: 16797416 06/27/2006
  • Role of immune cells in animal models for inherited peripheral neuropathies. (Wang Ip C, Kroner A, Fischer S, Berghoff M, Kobsar I, Mäurer M, Martini R) Neuromolecular Med 2006;8(1-2):175-90 PMID: 16775375 06/16/2006
  • Iron particle-enhanced visualization of inflammatory central nervous system lesions by high resolution: preliminary data in an animal model. (Linker RA, Kroner A, Horn T, Gold R, Mäurer M, Bendszus M) AJNR Am J Neuroradiol 2006 Jun-Jul;27(6):1225-9 PMID: 16775269 06/16/2006
  • Attenuated demyelination in the absence of the macrophage-restricted adhesion molecule sialoadhesin (Siglec-1) in mice heterozygously deficient in P0. (Kobsar I, Oetke C, Kroner A, Wessig C, Crocker P, Martini R) Mol Cell Neurosci 2006 Apr;31(4):685-91 PMID: 16458537 02/07/2006
  • A member of the transforming growth factor-beta receptor family from Echinococcus multilocularis is activated by human bone morphogenetic protein 2. (Zavala-Góngora R, Kroner A, Bernthaler P, Knaus P, Brehm K) Mol Biochem Parasitol 2006 Apr;146(2):265-71 PMID: 16434111 01/26/2006
  • Association of a common polymorphism in the promoter of UCP2 with susceptibility to multiple sclerosis. (Vogler S, Goedde R, Miterski B, Gold R, Kroner A, Koczan D, Zettl UK, Rieckmann P, Epplen JT, Ibrahim SM) J Mol Med (Berl) 2005 Oct;83(10):806-11 PMID: 16021520 07/16/2005
  • Impact of the Asp299Gly polymorphism in the toll-like receptor 4 (tlr-4) gene on disease course of multiple sclerosis. (Kroner A, Vogel F, Kolb-Mäurer A, Kruse N, Toyka KV, Hemmer B, Rieckmann P, Mäurer M) J Neuroimmunol 2005 Aug;165(1-2):161-5 PMID: 15932772 06/04/2005
  • A PD-1 polymorphism is associated with disease progression in multiple sclerosis. (Kroner A, Mehling M, Hemmer B, Rieckmann P, Toyka KV, Mäurer M, Wiendl H) Ann Neurol 2005 Jul;58(1):50-7 PMID: 15912506 05/25/2005
  • The role of the polio virus receptor and the herpesvirus entry mediator B genes for the development of MS. (Rosche B, Cepok S, Stei S, Vogel F, Grummel V, Hoffmann S, Kroner A, Mäurer M, Rieckmann P, Sommer N, Hemmer B) J Neuroimmunol 2004 Nov;156(1-2):171-7 PMID: 15465608 10/07/2004
  • Analysis of the monocyte chemoattractant protein 1 -2518 promoter polymorphism in patients with multiple sclerosis. (Kroner A, Mäurer M, Loserth S, Kleinschnitz C, Hemmer B, Rosche B, Toyka KV, Rieckmann P) Tissue Antigens 2004 Jul;64(1):70-3 PMID: 15191525 06/12/2004
  • Identification, molecular characterization and expression of the gene encoding the epidermal growth factor receptor orthologue from the fox-tapeworm Echinococcus multilocularis. (Spiliotis M, Kroner A, Brehm K) Gene 2003 Dec 24;323:57-65 PMID: 14659879 12/09/2003
  • Identification and characterisation of two distinct Smad proteins from the fox-tapeworm Echinococcus multilocularis. (Zavala-Góngora R, Kroner A, Wittek B, Knaus P, Brehm K) Int J Parasitol 2003 Dec;33(14):1665-77 PMID: 14636682 11/26/2003
  • Analysis of differential gene expression in Echinococcus multilocularis larval stages by means of spliced leader differential display. (Brehm K, Wolf M, Beland H, Kroner A, Frosch M) Int J Parasitol 2003 Sep 30;33(11):1145-59 PMID: 13678631 09/19/2003
  • Identification and molecular characterisation of a gene encoding a member of the insulin receptor family in Echinococcus multilocularis. (Konrad C, Kroner A, Spiliotis M, Zavala-Góngora R, Brehm K) Int J Parasitol 2003 Mar;33(3):301-12 PMID: 12670515 04/03/2003
  • Last update: 07/21/2017
    jenkins-FCD Prod-130 96200611f8481f0aa4f84230b11dd74d063847a3