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Roy L. Silverstein MD

Chair, Center Associate Director, Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Administration
Program: Chairman

Member of the Cancer Center
Member of the Cardiovascular Center
Member of the Center for Disease Prevention Research (CDPR)
Member of the Genomic Sciences and Precision Medicine Center (GSPMC)

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Publications (211)

A CD36 transmembrane domain peptide interrupts CD36 interactions with membrane partners on macrophages and inhibits atherogenic functions. (Huang W, Li R, Zhang J, Cheng Y, Ramakrishnan DP, Silverstein RL) Transl Res 2022 Nov 12 PMID: 36377115 SCOPUS ID: 2-s2.0-85143169438 11/16/2022

Na/K-ATPase suppresses LPS-induced pro-inflammatory signaling through Lyn. (Zhang J, Chang J, Beg MA, Huang W, Zhao Y, Dai W, Wu X, Cui W, Pillai SS, Lakhani HV, Sodhi K, Shapiro JI, Sahoo D, Zheng Z, Silverstein RL, Chen Y) iScience 2022 Sep 16;25(9):104963 PMID: 36072548 PMCID: PMC9442361 SCOPUS ID: 2-s2.0-85137074779 09/09/2022

Plasma Membrane Localization of CD36 Requires Vimentin Phosphorylation; A Mechanism by Which Macrophage Vimentin Promotes Atherosclerosis. (Kim SY, Jeong SJ, Park JH, Cho W, Ahn YH, Choi YH, Oh GT, Silverstein RL, Park YM) Front Cardiovasc Med 2022;9:792717 PMID: 35656400 PMCID: PMC9152264 SCOPUS ID: 2-s2.0-85138537776 06/04/2022

CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate. (Chen Y, Zhang J, Cui W, Silverstein RL) J Exp Med 2022 Jun 06;219(6) PMID: 35438721 PMCID: PMC9022290 SCOPUS ID: 2-s2.0-85128794972 04/20/2022 18 Citations

Development of an arteriolar niche and self-renewal of breast cancer stem cells by lysophosphatidic acid/protein kinase D signaling (Jiang Y, Guo Y, Hao J, Guenter R, Lathia J, Beck AW, Hattaway R, Hurst D, Wang QJ, Liu Y, Cao Q, Krontiras H, Chen H, Silverstein R, Ren B) Communications Biology December 2021;4(1) SCOPUS ID: 2-s2.0-85108778647 12/01/2021 1 Citation

Hypertriglyceridemia during hospitalization independently associates with mortality in patients with COVID-19. (Dai W, Lund H, Chen Y, Zhang J, Osinski K, Jones SZ, Kreuziger LB, López JA, Benjamin IJ, Silverstein RL, Zheng Z) J Clin Lipidol 2021;15(5):724-731 PMID: 34470719 PMCID: PMC8353976 SCOPUS ID: 2-s2.0-85114047849 09/03/2021 6 Citations

AMPK-deficiency forces metformin-challenged cancer cells to switch from carbohydrate metabolism to ketogenesis to support energy metabolism. (Palma FR, Ratti BA, Paviani V, Coelho DR, Miguel R, Danes JM, Zaichik SV, de Abreu AL, Silva SO, Chen Y, Silverstein RL, Karan U, Jones DP, Bonini MG) Oncogene 2021 Sep;40(36):5455-5467 PMID: 34290400 PMCID: PMC8669831 SCOPUS ID: 2-s2.0-85110982210 07/23/2021 8 Citations

PCSK9 (Proprotein Convertase Subtilisin/Kexin 9) Goes "DAMP". (Silverstein RL) Circulation 2021 Jan 05;143(1):62-64 PMID: 33378238 PMCID: PMC8006907 SCOPUS ID: 2-s2.0-85099206085 12/31/2020 4 Citations

Cysteine sulfenylation by CD36 signaling promotes arterial thrombosis in dyslipidemia. (Yang M, Li W, Harberg C, Chen W, Yue H, Ferreira RB, Wynia-Smith SL, Carroll KS, Zielonka J, Flaumenhaft R, Silverstein RL, Smith BC) Blood Adv 2020 Sep 22;4(18):4494-4507 PMID: 32946569 PMCID: PMC7509873 SCOPUS ID: 2-s2.0-85092260584 09/19/2020 9 Citations

Oxidant-induced alterations in the adipocyte transcriptome: Role of the na,k-atpase oxidant amplification loop (Sodhi K, Denvir J, Liu J, Sanabria JR, Chen Y, Silverstein R, Xie Z, Abraham NG, Shapiro JI) International Journal of Molecular Sciences 2 August 2020;21(16):1-25 SCOPUS ID: 2-s2.0-85089702929 08/02/2020 5 Citations

Mitochondrial Metabolic Reprogramming by CD36 Signaling Drives Macrophage Inflammatory Responses. (Chen Y, Yang M, Huang W, Chen W, Zhao Y, Schulte ML, Volberding P, Gerbec Z, Zimmermann MT, Zeighami A, Demos W, Zhang J, Knaack DA, Smith BC, Cui W, Malarkannan S, Sodhi K, Shapiro JI, Xie Z, Sahoo D, Silverstein RL) Circ Res 2019 Dec 06;125(12):1087-1102 PMID: 31625810 PMCID: PMC6921463 SCOPUS ID: 2-s2.0-85076330129 10/19/2019 62 Citations

Modification of HDL by reactive aldehydes alters select cardioprotective functions of HDL in macrophages. (Schill RL, Knaack DA, Powers HR, Chen Y, Yang M, Schill DJ, Silverstein RL, Sahoo D) FEBS J 2020 Feb;287(4):695-707 PMID: 31386799 PMCID: PMC7002295 SCOPUS ID: 2-s2.0-85070750063 08/07/2019 9 Citations

CD36 and ERK5 link dyslipidemia to apoptotic-like platelet procoagulant function. (Yang M, Silverstein RL) Curr Opin Hematol 2019 Sep;26(5):357-365 PMID: 31261174 PMCID: PMC9308374 SCOPUS ID: 2-s2.0-85070849797 07/02/2019 9 Citations

CD36 signaling in vascular redox stress. (Yang M, Silverstein RL) Free Radic Biol Med 2019 May 20;136:159-171 PMID: 30825500 PMCID: PMC6488418 SCOPUS ID: 2-s2.0-85062659543 03/03/2019 30 Citations

Platelets inhibit apoptotic lung epithelial cell death and protect mice against infection-induced lung injury. (Bain W, Olonisakin T, Yu M, Qu Y, Hulver M, Xiong Z, Li H, Pilewski J, Mallampalli RK, Nouraie M, Ray A, Ray P, Cheng Z, Shanks RMQ, St Croix C, Silverstein RL, Lee JS) Blood Adv 2019 Feb 12;3(3):432-445 PMID: 30733303 PMCID: PMC6373758 SCOPUS ID: 2-s2.0-85061225330 02/09/2019 16 Citations

CD36 Enhances Vascular Smooth Muscle Cell Proliferation and Development of Neointimal Hyperplasia. (Yue H, Febbraio M, Klenotic PA, Kennedy DJ, Wu Y, Chen S, Gohara AF, Li O, Belcher A, Kuang B, McIntyre TM, Silverstein RL, Li W) Arterioscler Thromb Vasc Biol 2019 Feb;39(2):263-275 PMID: 30567481 PMCID: PMC6345504 SCOPUS ID: 2-s2.0-85060389544 12/21/2018 21 Citations

Platelet CD36 signaling through ERK5 promotes caspase-dependent procoagulant activity and fibrin deposition in vivo. (Yang M, Kholmukhamedov A, Schulte ML, Cooley BC, Scoggins NO, Wood JP, Cameron SJ, Morrell CN, Jobe SM, Silverstein RL) Blood Adv 2018 Nov 13;2(21):2848-2861 PMID: 30381401 PMCID: PMC6234364 SCOPUS ID: 2-s2.0-85062651330 11/02/2018 31 Citations

Platelet metabolism meets thrombosis. (Chen Y, Silverstein RL) Blood 2018 Sep 13;132(11):1089-1091 PMID: 30213838 SCOPUS ID: 2-s2.0-85053125219 09/15/2018 2 Citations

Atherothrombosis (Silverstein RL) Hematology: Basic Principles and Practice 2018:2122-2132 SCOPUS ID: 2-s2.0-85055819537 01/01/2018

Oxidized Lipid Uptake by Scavenger Receptor CD36 (Cluster of Differentiation 36) Modulates Endothelial Surface Properties and May Contribute to Atherogenesis. (Silverstein RL) Arterioscler Thromb Vasc Biol 2018 Jan;38(1):4-5 PMID: 29282244 PMCID: PMC5751929 SCOPUS ID: 2-s2.0-85039446607 12/29/2017 4 Citations

Cardiotonic Steroids Stimulate Macrophage Inflammatory Responses Through a Pathway Involving CD36, TLR4, and Na/K-ATPase. (Chen Y, Huang W, Yang M, Xin G, Cui W, Xie Z, Silverstein RL) Arterioscler Thromb Vasc Biol 2017 Aug;37(8):1462-1469 PMID: 28619997 PMCID: PMC5532064 SCOPUS ID: 2-s2.0-85020518621 06/18/2017 16 Citations

Linking Metabolic Dysfunction to Atherosclerosis Via Activation of Macrophage CD36 Gene Transcription by Retinol Binding Protein-4. (Silverstein RL) Circulation 2017 Apr 04;135(14):1355-1356 PMID: 28373527 PMCID: PMC5415385 SCOPUS ID: 2-s2.0-85016994160 04/05/2017 7 Citations

Platelet CD36 promotes thrombosis by activating redox sensor ERK5 in hyperlipidemic conditions. (Yang M, Cooley BC, Li W, Chen Y, Vasquez-Vivar J, Scoggins NO, Cameron SJ, Morrell CN, Silverstein RL) Blood 2017 May 25;129(21):2917-2927 PMID: 28336528 PMCID: PMC5445574 SCOPUS ID: 2-s2.0-85019661296 03/25/2017 51 Citations

Diet-induced obesity links to ER positive breast cancer progression via LPA/PKD-1-CD36 signaling-mediated microvascular remodeling. (Dong L, Yuan Y, Opansky C, Chen Y, Aguilera-Barrantes I, Wu S, Yuan R, Cao Q, Cheng YC, Sahoo D, Silverstein RL, Ren B) Oncotarget 2017 Apr 04;8(14):22550-22562 PMID: 28186980 PMCID: PMC5410244 SCOPUS ID: 2-s2.0-85016933174 02/12/2017 25 Citations

Atherothrombosis (Silverstein RL) Hematology: Basic Principles and Practice 1 January 2017:2122-2132 SCOPUS ID: 2-s2.0-85141079578 01/01/2017

CD36 Provides Host Protection Against Klebsiella pneumoniae Intrapulmonary Infection by Enhancing Lipopolysaccharide Responsiveness and Macrophage Phagocytosis. (Olonisakin TF, Li H, Xiong Z, Kochman EJ, Yu M, Qu Y, Hulver M, Kolls JK, St Croix C, Doi Y, Nguyen MH, Shanks RM, Mallampalli RK, Kagan VE, Ray A, Silverstein RL, Ray P, Lee JS) J Infect Dis 2016 Dec 15;214(12):1865-1875 PMID: 27683817 PMCID: PMC5142085 SCOPUS ID: 2-s2.0-85016050287 09/30/2016 21 Citations

Circulating protein Z concentration, PROZ variants, and unexplained cerebral infarction in young and middle-aged adults. (Zhang L, Segal AZ, Leifer D, Silverstein RL, Gerber LM, Devereux RB, Kizer JR) Thromb Haemost 2017 Jan 05;117(1):149-157 PMID: 27683756 PMCID: PMC5798600 SCOPUS ID: 2-s2.0-85007367223 09/30/2016 5 Citations

Metabolic Manipulation to Put the Brakes on Platelet Activation: A Potential Novel Pharmacologic Approach to Atherothrombosis. (Silverstein RL) Arterioscler Thromb Vasc Biol 2016 Oct;36(10):2031-2 PMID: 27655777 SCOPUS ID: 2-s2.0-84988659974 09/23/2016

LPA/PKD-1-FoxO1 Signaling Axis Mediates Endothelial Cell CD36 Transcriptional Repression and Proangiogenic and Proarteriogenic Reprogramming. (Ren B, Best B, Ramakrishnan DP, Walcott BP, Storz P, Silverstein RL) Arterioscler Thromb Vasc Biol 2016 Jun;36(6):1197-208 PMID: 27013613 PMCID: PMC4882231 SCOPUS ID: 2-s2.0-84961564532 03/26/2016 33 Citations

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk. (Zhu W, Gregory JC, Org E, Buffa JA, Gupta N, Wang Z, Li L, Fu X, Wu Y, Mehrabian M, Sartor RB, McIntyre TM, Silverstein RL, Tang WHW, DiDonato JA, Brown JM, Lusis AJ, Hazen SL) Cell 2016 Mar 24;165(1):111-124 PMID: 26972052 PMCID: PMC4862743 SCOPUS ID: 2-s2.0-84959922537 03/15/2016 1007 Citations

Extracellular Vesicles Activate a CD36-Dependent Signaling Pathway to Inhibit Microvascular Endothelial Cell Migration and Tube Formation. (Ramakrishnan DP, Hajj-Ali RA, Chen Y, Silverstein RL) Arterioscler Thromb Vasc Biol 2016 Mar;36(3):534-44 PMID: 26821945 PMCID: PMC4767682 SCOPUS ID: 2-s2.0-84959464380 01/30/2016 38 Citations

Atherothrombosis: Seeing Red? (Simon DI, Silverstein RL) Circulation 2015 Nov 17;132(20):1860-2 PMID: 26467255 PMCID: PMC4651722 SCOPUS ID: 2-s2.0-84947490742 10/16/2015 4 Citations

Erratum: "Oxidized LDL-bound CD36 recruits an Na⁺/K⁺-ATPase-Lyn complex in macrophages that promotes atherosclerosis" (Science Signaling (2015) 8:397 (er7)) (Chen Y, Kennedy DJ, Ramakrishnan DP, Yang M, Huang W, Li Z, Xie Z, Chadwick AC, Sahoo D, Silverstein RL) Science Signaling 6 October 2015;8(397) SCOPUS ID: 2-s2.0-84943809115 10/06/2015

Oxidized LDL-bound CD36 recruits an Na⁺/K⁺-ATPase-Lyn complex in macrophages that promotes atherosclerosis. (Chen Y, Kennedy DJ, Ramakrishnan DP, Yang M, Huang W, Li Z, Xie Z, Chadwick AC, Sahoo D, Silverstein RL) Sci Signal 2015 Sep 08;8(393):ra91 PMID: 26350901 PMCID: PMC4852751 SCOPUS ID: 2-s2.0-84941034207 09/10/2015 58 Citations

Science Signaling Podcast for 8 September 2015: Turning macrophages into foam cells (Silverstein RL, VanHook AM) Science Signaling 8 September 2015;8(393) SCOPUS ID: 2-s2.0-84941115170 09/08/2015

The interface of inflammation and subclinical atherosclerosis in granulomatosis with polyangiitis (Wegener's): a preliminary study. (Hajj-Ali RA, Major J, Langford C, Hoffman GS, Clark T, Zhang L, Sun Z, Silverstein RL) Transl Res 2015 Oct;166(4):366-74 PMID: 26024800 PMCID: PMC4862201 SCOPUS ID: 2-s2.0-84941313968 05/31/2015 13 Citations

Disabling the platelet's brakes to promote thrombosis. (Silverstein RL) Blood 2015 Apr 23;125(17):2591-3 PMID: 25907902 SCOPUS ID: 2-s2.0-84928317219 04/25/2015 5 Citations

Acrolein impairs the cholesterol transport functions of high density lipoproteins. (Chadwick AC, Holme RL, Chen Y, Thomas MJ, Sorci-Thomas MG, Silverstein RL, Pritchard KA Jr, Sahoo D) PLoS One 2015;10(4):e0123138 PMID: 25849485 PMCID: PMC4388475 SCOPUS ID: 2-s2.0-84927672521 04/08/2015 30 Citations

Thrombospondin-1 restrains neutrophil granule serine protease function and regulates the innate immune response during Klebsiella pneumoniae infection. (Zhao Y, Olonisakin TF, Xiong Z, Hulver M, Sayeed S, Yu MT, Gregory AD, Kochman EJ, Chen BB, Mallampalli RK, Sun M, Silverstein RL, Stolz DB, Shapiro SD, Ray A, Ray P, Lee JS) Mucosal Immunol 2015 Jul;8(4):896-905 PMID: 25492474 PMCID: PMC4465063 SCOPUS ID: 2-s2.0-84932618977 12/11/2014 32 Citations

Thymidine phosphorylase participates in platelet signaling and promotes thrombosis. (Li W, Gigante A, Perez-Perez MJ, Yue H, Hirano M, McIntyre TM, Silverstein RL) Circ Res 2014 Dec 05;115(12):997-1006 PMID: 25287063 PMCID: PMC4258140 SCOPUS ID: 2-s2.0-84917682250 10/08/2014 24 Citations

Hyper-inflammation and skin destruction mediated by rosiglitazone activation of macrophages in IL-6 deficiency. (Das LM, Rosenjack J, Au L, Galle PS, Hansen MB, Cathcart MK, McCormick TS, Cooper KD, Silverstein RL, Lu KQ) J Invest Dermatol 2015 Feb;135(2):389-399 PMID: 25184961 PMCID: PMC4291681 SCOPUS ID: 2-s2.0-84930182637 09/04/2014 11 Citations

Exosome poly-ubiquitin inhibits platelet activation, downregulates CD36 and inhibits pro-atherothombotic cellular functions. (Srikanthan S, Li W, Silverstein RL, McIntyre TM) J Thromb Haemost 2014 Nov;12(11):1906-17 PMID: 25163645 PMCID: PMC4229405 SCOPUS ID: 2-s2.0-84916633753 08/29/2014 74 Citations

Platelet CD36 links not only α-granule-derived proteins to thrombus stability but also metabolic and oxidant stress to a prothrombotic phenotype. (Silverstein RL) Arterioscler Thromb Vasc Biol 2014 Jun;34(6):1120-1 PMID: 24828516 PMCID: PMC4629480 SCOPUS ID: 2-s2.0-84901312922 05/16/2014 5 Citations

Cancer stem cell-specific scavenger receptor CD36 drives glioblastoma progression. (Hale JS, Otvos B, Sinyuk M, Alvarado AG, Hitomi M, Stoltz K, Wu Q, Flavahan W, Levison B, Johansen ML, Schmitt D, Neltner JM, Huang P, Ren B, Sloan AE, Silverstein RL, Gladson CL, DiDonato JA, Brown JM, McIntyre T, Hazen SL, Horbinski C, Rich JN, Lathia JD) Stem Cells 2014 Jul;32(7):1746-58 PMID: 24737733 PMCID: PMC4063873 SCOPUS ID: 2-s2.0-84902578963 04/17/2014 140 Citations

Platelet-derived S100 family member myeloid-related protein-14 regulates thrombosis. (Wang Y, Fang C, Gao H, Bilodeau ML, Zhang Z, Croce K, Liu S, Morooka T, Sakuma M, Nakajima K, Yoneda S, Shi C, Zidar D, Andre P, Stephens G, Silverstein RL, Hogg N, Schmaier AH, Simon DI) J Clin Invest 2014 May;124(5):2160-71 PMID: 24691441 PMCID: PMC4001535 SCOPUS ID: 2-s2.0-84899762473 04/03/2014 94 Citations

Disorders of platelets and coagulation (Samaras CJ, Deitcher SR, Silverstein RL, Silver BJ) The Cleveland Clinic Foundation Intensive Review of Internal Medicine: Sixth Edition 20 February 2014:125 SCOPUS ID: 2-s2.0-84974808330 02/20/2014

Proteasome proteolysis supports stimulated platelet function and thrombosis. (Gupta N, Li W, Willard B, Silverstein RL, McIntyre TM) Arterioscler Thromb Vasc Biol 2014 Jan;34(1):160-8 PMID: 24177323 PMCID: PMC4059534 SCOPUS ID: 2-s2.0-84891826294 11/02/2013 41 Citations

Lipopolysaccharide stimulates platelets through an IL-1β autocrine loop. (Brown GT, Narayanan P, Li W, Silverstein RL, McIntyre TM) J Immunol 2013 Nov 15;191(10):5196-203 PMID: 24081990 PMCID: PMC3818355 SCOPUS ID: 2-s2.0-84887480564 10/02/2013 92 Citations

Thrombospondin-1 triggers macrophage IL-10 production and promotes resolution of experimental lung injury. (Zhao Y, Xiong Z, Lechner EJ, Klenotic PA, Hamburg BJ, Hulver M, Khare A, Oriss T, Mangalmurti N, Chan Y, Zhang Y, Ross MA, Stolz DB, Rosengart MR, Pilewski J, Ray P, Ray A, Silverstein RL, Lee JS) Mucosal Immunol 2014 Mar;7(2):440-8 PMID: 24045574 PMCID: PMC3945733 SCOPUS ID: 2-s2.0-84895085298 09/21/2013 47 Citations

Loci influencing blood pressure identified using a cardiovascular gene-centric array (Ganesh SK, Tragante V, Guo W, Guo Y, Lanktree MB, Smith EN, Johnson T, Castillo BA, Barnard J, Baumert J, Chang YPC, Elbers CC, Farrall M, Fischer ME, Gaunt NF, Johannes JMI, Gieger C, Gong Y, Isaacs A, Kleber ME, Leach IM, McDonough CW, Meijs MFL, Mellander O, Molony CM, Nolte IM, Price SP, Rajagopalan R, Shaffer J, Shah S, Shen H, Soranzo N, van der Most PJ, Van Iperen EPA, Van Setten J, Vonk JM, Zhang L, Beitelshees AL, Berenson GS, Bhatt DL, Boer JMA, Boerwinkle E, Burkley B, Burt A, Chakravarti A, Chen W, Cooper-DeHoff RM, Curtis SP, Dreisbach A, Duggan D, Ehret GB, Fabsitz RR, Fornage M, Fox E, Furlong CE, Gansevoort RT, Hofker MH, Hovingh GK, Kirkland SA, Kottke-Marchant K, Kutlar A, LaCroix AZ, Langaee TY, Li YR, Lin H, Liu K, Maiwald S, Malik R, Metastroke C, Murugesan G, Newton-Cheh C, O'Connell JR, Onland-Moret NC, Ouwehand WH, Palmas W, Penninx BW, Pepine CJ, Pettinger M, Polak JF, Ramachandran VS, Ranchalis J, Redline S, Ridker PM, Rose LM, Scharnag H, Schork NJ, Shimbo D, Shuldiner AR, Srinivasan SR, Stolk RP, Taylor HA, Thorand B, Trip MD, van Duijn CM, Verschuren WM, Wijmenga C, Winkelmann BR, Wyatt S, Young JH, Boehm BO) Human Molecular Genetics August 2013;22(16):3394-3395 SCOPUS ID: 2-s2.0-84881219802 08/01/2013 10 Citations

Thrombospondin-1 modulates VEGF signaling via CD36 by recruiting SHP-1 to VEGFR2 complex in microvascular endothelial cells. (Chu LY, Ramakrishnan DP, Silverstein RL) Blood 2013 Sep 05;122(10):1822-32 PMID: 23896411 PMCID: PMC3765061 SCOPUS ID: 2-s2.0-84886448895 07/31/2013 98 Citations

Vav Guanine nucleotide exchange factors regulate atherosclerotic lesion development in mice. (Rahaman SO, Li W, Silverstein RL) Arterioscler Thromb Vasc Biol 2013 Sep;33(9):2053-7 PMID: 23825362 PMCID: PMC3864095 SCOPUS ID: 2-s2.0-84883261411 07/05/2013 18 Citations

Nicotine potentiates proatherogenic effects of oxLDL by stimulating and upregulating macrophage CD36 signaling. (Zhou MS, Chadipiralla K, Mendez AJ, Jaimes EA, Silverstein RL, Webster K, Raij L) Am J Physiol Heart Circ Physiol 2013 Aug 15;305(4):H563-74 PMID: 23748423 PMCID: PMC3891251 SCOPUS ID: 2-s2.0-84881625230 06/12/2013 50 Citations

Molecular basis of antiangiogenic thrombospondin-1 type 1 repeat domain interactions with CD36. (Klenotic PA, Page RC, Li W, Amick J, Misra S, Silverstein RL) Arterioscler Thromb Vasc Biol 2013 Jul;33(7):1655-62 PMID: 23640500 PMCID: PMC3737738 SCOPUS ID: 2-s2.0-84879103346 05/04/2013 31 Citations

Loci influencing blood pressure identified using a cardiovascular gene-centric array. (Ganesh SK, Tragante V, Guo W, Guo Y, Lanktree MB, Smith EN, Johnson T, Castillo BA, Barnard J, Baumert J, Chang YP, Elbers CC, Farrall M, Fischer ME, Franceschini N, Gaunt TR, Gho JM, Gieger C, Gong Y, Isaacs A, Kleber ME, Mateo Leach I, McDonough CW, Meijs MF, Mellander O, Molony CM, Nolte IM, Padmanabhan S, Price TS, Rajagopalan R, Shaffer J, Shah S, Shen H, Soranzo N, van der Most PJ, Van Iperen EP, Van Setten J, Vonk JM, Zhang L, Beitelshees AL, Berenson GS, Bhatt DL, Boer JM, Boerwinkle E, Burkley B, Burt A, Chakravarti A, Chen W, Cooper-Dehoff RM, Curtis SP, Dreisbach A, Duggan D, Ehret GB, Fabsitz RR, Fornage M, Fox E, Furlong CE, Gansevoort RT, Hofker MH, Hovingh GK, Kirkland SA, Kottke-Marchant K, Kutlar A, Lacroix AZ, Langaee TY, Li YR, Lin H, Liu K, Maiwald S, Malik R, CARDIOGRAM, METASTROKE, Murugesan G, Newton-Cheh C, O'Connell JR, Onland-Moret NC, Ouwehand WH, Palmas W, Penninx BW, Pepine CJ, Pettinger M, Polak JF, Ramachandran VS, Ranchalis J, Redline S, Ridker PM, Rose LM, Scharnag H, Schork NJ, Shimbo D, Shuldiner AR, Srinivasan SR, Stolk RP, Taylor HA, Thorand B, Trip MD, van Duijn CM, Verschuren WM, Wijmenga C, Winkelmann BR, Wyatt S, Young JH, Boehm BO, Caulfield MJ, Chasman DI, Davidson KW, Doevendans PA, Fitzgerald GA, Gums JG, Hakonarson H, Hillege HL, Illig T, Jarvik GP, Johnson JA, Kastelein JJ, Koenig W, LifeLines Cohort Study, März W, Mitchell BD, Murray SS, Oldehinkel AJ, Rader DJ, Reilly MP, Reiner AP, Schadt EE, Silverstein RL, Snieder H, Stanton AV, Uitterlinden AG, van der Harst P, van der Schouw YT, Samani NJ, Johnson AD, Munroe PB, de Bakker PI, Zhu X, Levy D, Keating BJ, Asselbergs FW) Hum Mol Genet 2013 Apr 15;22(8):1663-78 PMID: 23303523 PMCID: PMC3657476 SCOPUS ID: 2-s2.0-84875781416 01/11/2013 102 Citations

Ferric chloride-induced murine carotid arterial injury: A model of redox pathology. (Li W, McIntyre TM, Silverstein RL) Redox Biol 2013;1(1):50-5 PMID: 25101237 PMCID: PMC4116643 SCOPUS ID: 2-s2.0-84878783769 01/01/2013 59 Citations

CD36 and Na/K-ATPase-α1 form a proinflammatory signaling loop in kidney. (Kennedy DJ, Chen Y, Huang W, Viterna J, Liu J, Westfall K, Tian J, Bartlett DJ, Tang WH, Xie Z, Shapiro JI, Silverstein RL) Hypertension 2013 Jan;61(1):216-24 PMID: 23172921 PMCID: PMC3521864 SCOPUS ID: 2-s2.0-84871620197 11/23/2012 64 Citations

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. (Asselbergs FW, Guo Y, van Iperen EP, Sivapalaratnam S, Tragante V, Lanktree MB, Lange LA, Almoguera B, Appelman YE, Barnard J, Baumert J, Beitelshees AL, Bhangale TR, Chen YD, Gaunt TR, Gong Y, Hopewell JC, Johnson T, Kleber ME, Langaee TY, Li M, Li YR, Liu K, McDonough CW, Meijs MF, Middelberg RP, Musunuru K, Nelson CP, O'Connell JR, Padmanabhan S, Pankow JS, Pankratz N, Rafelt S, Rajagopalan R, Romaine SP, Schork NJ, Shaffer J, Shen H, Smith EN, Tischfield SE, van der Most PJ, van Vliet-Ostaptchouk JV, Verweij N, Volcik KA, Zhang L, Bailey KR, Bailey KM, Bauer F, Boer JM, Braund PS, Burt A, Burton PR, Buxbaum SG, Chen W, Cooper-Dehoff RM, Cupples LA, deJong JS, Delles C, Duggan D, Fornage M, Furlong CE, Glazer N, Gums JG, Hastie C, Holmes MV, Illig T, Kirkland SA, Kivimaki M, Klein R, Klein BE, Kooperberg C, Kottke-Marchant K, Kumari M, LaCroix AZ, Mallela L, Murugesan G, Ordovas J, Ouwehand WH, Post WS, Saxena R, Scharnagl H, Schreiner PJ, Shah T, Shields DC, Shimbo D, Srinivasan SR, Stolk RP, Swerdlow DI, Taylor HA Jr, Topol EJ, Toskala E, van Pelt JL, van Setten J, Yusuf S, Whittaker JC, Zwinderman AH, LifeLines Cohort Study, Anand SS, Balmforth AJ, Berenson GS, Bezzina CR, Boehm BO, Boerwinkle E, Casas JP, Caulfield MJ, Clarke R, Connell JM, Cruickshanks KJ, Davidson KW, Day IN, de Bakker PI, Doevendans PA, Dominiczak AF, Hall AS, Hartman CA, Hengstenberg C, Hillege HL, Hofker MH, Humphries SE, Jarvik GP, Johnson JA, Kaess BM, Kathiresan S, Koenig W, Lawlor DA, März W, Melander O, Mitchell BD, Montgomery GW, Munroe PB, Murray SS, Newhouse SJ, Onland-Moret NC, Poulter N, Psaty B, Redline S, Rich SS, Rotter JI, Schunkert H, Sever P, Shuldiner AR, Silverstein RL, Stanton A, Thorand B, Trip MD, Tsai MY, van der Harst P, van der Schoot E, van der Schouw YT, Verschuren WM, Watkins H, Wilde AA, Wolffenbuttel BH, Whitfield JB, Hovingh GK, Ballantyne CM, Wijmenga C, Reilly MP, Martin NG, Wilson JG, Rader DJ, Samani NJ, Reiner AP, Hegele RA, Kastelein JJ, Hingorani AD, Talmud PJ, Hakonarson H, Elbers CC, Keating BJ, Drenos F) Am J Hum Genet 2012 Nov 02;91(5):823-38 PMID: 23063622 PMCID: PMC3487124 SCOPUS ID: 2-s2.0-84868470681 10/16/2012 194 Citations

Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. (Guo Y, Lanktree MB, Taylor KC, Hakonarson H, Lange LA, Keating BJ, IBC 50K SNP array BMI Consortium) Hum Mol Genet 2013 Jan 01;22(1):184-201 PMID: 23001569 PMCID: PMC3522401 SCOPUS ID: 2-s2.0-84871223778 09/25/2012 68 Citations

Context dependent role of the CD36--thrombospondin--histidine-rich glycoprotein axis in tumor angiogenesis and growth. (Hale JS, Li M, Sinyuk M, Jahnen-Dechent W, Lathia JD, Silverstein RL) PLoS One 2012;7(7):e40033 PMID: 22808089 PMCID: PMC3393734 SCOPUS ID: 2-s2.0-84863711486 07/19/2012 23 Citations

Oxidized LDL/CD36 interaction induces loss of cell polarity and inhibits macrophage locomotion. (Park YM, Drazba JA, Vasanji A, Egelhoff T, Febbraio M, Silverstein RL) Mol Biol Cell 2012 Aug;23(16):3057-68 PMID: 22718904 PMCID: PMC3418302 SCOPUS ID: 2-s2.0-84865209913 06/22/2012 51 Citations

Erratum: Meta-analysis of dense genecentric association studies reveals common and uncommon variants associated with height ((The American Journal of Human Genetics (2010) 88 (6-18)) (Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H, Rajagopalan R, Johnson T, Shen H, Nelson CP, Klopp N, Baumert J, Padmanabhan S, Pankratz N, Pankow JS, Shah S, Taylor K, Barnard J, Peters BJ, Maloney CM, Lobmeyer MT, Stanton A, Zafarmand MH, Romaine SPR, Mehta A, Van Iperen EPA, Gong Y, Price TS, Smith EN, Kim CE, Li YR, Asselbergs FW, Atwood LD, Bailey KM, Bhatt D, Bauer F, Behr ER, Bhangale T, Boer JMA, Boehm BO, Bradfield JP, Brown M, Braund PS, Burton PR, Carty C, Chandrupatla HR, Chen W, Connell J, Dalgeorgou C, De Boer A, Drenos F, Elbers CC, Fang JC, Fox CS, Frackelton EC, Fuchs B, Furlong CE, Gibson Q, Gieger C, Goel A, Grobbee DE, Hastie C, Howard PJ, Huang GH, Johnson WC, Li Q, Kleber ME, Klein BEK, Klein R, Kooperberg C, Ky B, Lacroix A, Lanken P, Lathrop M, Li M, Marshall V, Melander O, Mentch FD, Meyer NJ, Monda KL, Montpetit A, Murugesan G, Nakayama K, Nondahl D, Onipinla A, Rafelt S, Newhouse SJ, Otieno FG, Patel SR, Putt ME, Rodriguez S, Safa RN, Sawyer DB, Schreiner PJ, Simpson C, Sivapalaratnam S, Srinivasan SR, Suver C) American Journal of Human Genetics 8 June 2012;90(6):1116-1117 SCOPUS ID: 2-s2.0-84862142549 06/08/2012

P2RY1 and P2RY12 polymorphisms and on-aspirin platelet reactivity in patients with coronary artery disease. (Timur AA, Murugesan G, Zhang L, Aung PP, Barnard J, Wang QK, Gaussem P, Silverstein RL, Bhatt DL, Kottke-Marchant K) Int J Lab Hematol 2012 Oct;34(5):473-83 PMID: 22574824 PMCID: PMC3419334 SCOPUS ID: 2-s2.0-84865552528 05/12/2012 26 Citations

Insulin promotes macrophage foam cell formation: potential implications in diabetes-related atherosclerosis. (Park YM, R Kashyap S, A Major J, Silverstein RL) Lab Invest 2012 Aug;92(8):1171-80 PMID: 22525426 PMCID: PMC3407326 SCOPUS ID: 2-s2.0-84864481830 04/25/2012 33 Citations

Erratum: Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci (American Journal of Human Genetics (2012) 90 (410-425)) (Saxena R, Elbers CC, Guo Y, Peter I, Gaunt TR, Mega JL, Lanktree MB, Tare A, Castillo BA, Li YR, Johnson T, Bruinenberg M, Gilbert-Diamond D, Rajagopalan R, Voight BF, Balasubramanyam A, Barnard J, Bauer F, Baumert J, Bhangale T, Böhm BO, Braund PS, Burton PR, Chandrupatla HR, Clarke R, Cooper-Dehoff RM, Crook ED, Davey-Smith G, Day IN, De Boer A, De Groot MCH, Drenos F, Ferguson J, Fox CS, Furlong CE, Gibson Q, Gieger C, Gilhuijs-Pederson LA, Glessner JT, Goel A, Gong Y, Grant SFA, Grobbee DE, Hastie C, Humphries SE, Kim CE, Kivimaki M, Kleber M, Meisinger C, Kumari M, Langaee TY, Lawlor DA, Li M, Lobmeyer MT, Maitland-Van Der Zee AH, Meijs MFL, Molony CM, Morrow DA, Murugesan G, Musani SK, Nelson CP, Newhouse SJ, O'Connell JR, Padmanabhan S, Palmen J, Patel SR, Pepine CJ, Pettinger M, Price TS, Rafelt S, Ranchalis J, Rasheed A, Rosenthal E, Ruczinski I, Shah S, Shen H, Silbernagel G, Smith EN, Spijkerman AWM, Stanton A, Steffes MW, Thorand B, Trip M, Van Der Harst P, Van Der A DL, Van Iperen EPA, Van Setten J, Van Vliet-Ostaptchouk JV, Verweij N, Wolffenbuttel BHR, Young T, Hadi Zafarmand M, Zmuda JM, Boehnke M, Altshuler D, McCarthy M, Linda Kao WH, Pankow JS, Cappola TP, Sever P) American Journal of Human Genetics 6 April 2012;90(4):753 SCOPUS ID: 2-s2.0-84859501327 04/06/2012 1 Citation

Advanced glycation end products induce a prothrombotic phenotype in mice via interaction with platelet CD36. (Zhu W, Li W, Silverstein RL) Blood 2012 Jun 21;119(25):6136-44 PMID: 22431576 PMCID: PMC3383021 SCOPUS ID: 2-s2.0-84862748475 03/21/2012 79 Citations

Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. (Saxena R, Elbers CC, Guo Y, Peter I, Gaunt TR, Mega JL, Lanktree MB, Tare A, Castillo BA, Li YR, Johnson T, Bruinenberg M, Gilbert-Diamond D, Rajagopalan R, Voight BF, Balasubramanyam A, Barnard J, Bauer F, Baumert J, Bhangale T, Böhm BO, Braund PS, Burton PR, Chandrupatla HR, Clarke R, Cooper-DeHoff RM, Crook ED, Davey-Smith G, Day IN, de Boer A, de Groot MC, Drenos F, Ferguson J, Fox CS, Furlong CE, Gibson Q, Gieger C, Gilhuijs-Pederson LA, Glessner JT, Goel A, Gong Y, Grant SF, Grobbee DE, Hastie C, Humphries SE, Kim CE, Kivimaki M, Kleber M, Meisinger C, Kumari M, Langaee TY, Lawlor DA, Li M, Lobmeyer MT, Maitland-van der Zee AH, Meijs MF, Molony CM, Morrow DA, Murugesan G, Musani SK, Nelson CP, Newhouse SJ, O'Connell JR, Padmanabhan S, Palmen J, Patel SR, Pepine CJ, Pettinger M, Price TS, Rafelt S, Ranchalis J, Rasheed A, Rosenthal E, Ruczinski I, Shah S, Shen H, Silbernagel G, Smith EN, Spijkerman AW, Stanton A, Steffes MW, Thorand B, Trip M, van der Harst P, van der A DL, van Iperen EP, van Setten J, van Vliet-Ostaptchouk JV, Verweij N, Wolffenbuttel BH, Young T, Zafarmand MH, Zmuda JM, Look AHEAD Research Group, DIAGRAM consortium, Boehnke M, Altshuler D, McCarthy M, Kao WH, Pankow JS, Cappola TP, Sever P, Poulter N, Caulfield M, Dominiczak A, Shields DC, Bhatt DL, Zhang L, Curtis SP, Danesh J, Casas JP, van der Schouw YT, Onland-Moret NC, Doevendans PA, Dorn GW 2nd, Farrall M, FitzGerald GA, Hamsten A, Hegele R, Hingorani AD, Hofker MH, Huggins GS, Illig T, Jarvik GP, Johnson JA, Klungel OH, Knowler WC, Koenig W, März W, Meigs JB, Melander O, Munroe PB, Mitchell BD, Bielinski SJ, Rader DJ, Reilly MP, Rich SS, Rotter JI, Saleheen D, Samani NJ, Schadt EE, Shuldiner AR, Silverstein R, Kottke-Marchant K, Talmud PJ, Watkins H, Asselbergs FW, de Bakker PI, McCaffery J, Wijmenga C, Sabatine MS, Wilson JG, Reiner A, Bowden DW, Hakonarson H, Siscovick DS, Keating BJ) Am J Hum Genet 2012 Mar 09;90(3):410-25 PMID: 22325160 PMCID: PMC3309185 SCOPUS ID: 2-s2.0-84862785585 02/14/2012 215 Citations

CD36 ectodomain phosphorylation blocks thrombospondin-1 binding: structure-function relationships and regulation by protein kinase C. (Chu LY, Silverstein RL) Arterioscler Thromb Vasc Biol 2012 Mar;32(3):760-7 PMID: 22247259 PMCID: PMC3298081 SCOPUS ID: 2-s2.0-84857648664 01/17/2012 24 Citations

CD9 tetraspanin interacts with CD36 on the surface of macrophages: a possible regulatory influence on uptake of oxidized low density lipoprotein. (Huang W, Febbraio M, Silverstein RL) PLoS One 2011;6(12):e29092 PMID: 22216174 PMCID: PMC3244426 SCOPUS ID: 2-s2.0-83755229079 01/05/2012 35 Citations

Teaching an old dog new tricks: potential antiatherothrombotic use for statins. (Silverstein RL) J Clin Invest 2012 Feb;122(2):478-81 PMID: 22214843 PMCID: PMC3266801 SCOPUS ID: 2-s2.0-84856545957 01/05/2012 1 Citation

Non-linear impedance characterization of blood cells-derived microparticle biomarkers suspensions (Smiechowski MF, Lvovich VF, Srikanthan S, Silverstein RL) Electrochimica Acta 30 September 2011;56(23):7763-7771 SCOPUS ID: 2-s2.0-80052712630 09/30/2011 2 Citations

Vav protein guanine nucleotide exchange factor regulates CD36 protein-mediated macrophage foam cell formation via calcium and dynamin-dependent processes. (Rahaman SO, Zhou G, Silverstein RL) J Biol Chem 2011 Oct 14;286(41):36011-36019 PMID: 21865158 PMCID: PMC3195569 SCOPUS ID: 2-s2.0-80053896976 08/26/2011 32 Citations

Expression, purification and structural characterization of functionally replete thrombospondin-1 type 1 repeats in a bacterial expression system. (Klenotic PA, Page RC, Misra S, Silverstein RL) Protein Expr Purif 2011 Dec;80(2):253-9 PMID: 21821127 PMCID: PMC3195888 SCOPUS ID: 2-s2.0-80054089028 08/09/2011 16 Citations

Loss of expression of neutrophil proteinase-3: a factor contributing to thrombotic risk in paroxysmal nocturnal hemoglobinuria. (Jankowska AM, Szpurka H, Calabro M, Mohan S, Schade AE, Clemente M, Silverstein RL, Maciejewski JP) Haematologica 2011 Jul;96(7):954-62 PMID: 21546506 PMCID: PMC3128213 SCOPUS ID: 2-s2.0-79959962456 05/07/2011 12 Citations

Platelet CD36 surface expression levels affect functional responses to oxidized LDL and are associated with inheritance of specific genetic polymorphisms. (Ghosh A, Murugesan G, Chen K, Zhang L, Wang Q, Febbraio M, Anselmo RM, Marchant K, Barnard J, Silverstein RL) Blood 2011 Jun 09;117(23):6355-66 PMID: 21478428 PMCID: PMC3122954 SCOPUS ID: 2-s2.0-79959465233 04/12/2011 81 Citations

Lysophosphatidic acid suppresses endothelial cell CD36 expression and promotes angiogenesis via a PKD-1-dependent signaling pathway. (Ren B, Hale J, Srikanthan S, Silverstein RL) Blood 2011 Jun 02;117(22):6036-45 PMID: 21441463 PMCID: PMC3112047 SCOPUS ID: 2-s2.0-79957982626 03/29/2011 38 Citations

Vav guanine nucleotide exchange factors link hyperlipidemia and a prothrombotic state. (Chen K, Li W, Major J, Rahaman SO, Febbraio M, Silverstein RL) Blood 2011 May 26;117(21):5744-50 PMID: 21427288 PMCID: PMC3110031 SCOPUS ID: 2-s2.0-79957586599 03/24/2011 51 Citations

Vav family Rho guanine nucleotide exchange factors regulate CD36-mediated macrophage foam cell formation. (Rahaman SO, Swat W, Febbraio M, Silverstein RL) J Biol Chem 2011 Mar 04;286(9):7010-7 PMID: 21209086 PMCID: PMC3044957 SCOPUS ID: 2-s2.0-79953212244 01/07/2011 31 Citations

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. (Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H, Rajagopalan R, Johnson T, Shen H, Nelson CP, Klopp N, Baumert J, Padmanabhan S, Pankratz N, Pankow JS, Shah S, Taylor K, Barnard J, Peters BJ, Maloney CM, Lobmeyer MT, Stanton A, Zafarmand MH, Romaine SP, Mehta A, van Iperen EP, Gong Y, Price TS, Smith EN, Kim CE, Li YR, Asselbergs FW, Atwood LD, Bailey KM, Bhatt D, Bauer F, Behr ER, Bhangale T, Boer JM, Boehm BO, Bradfield JP, Brown M, Braund PS, Burton PR, Carty C, Chandrupatla HR, Chen W, Connell J, Dalgeorgou C, Boer Ad, Drenos F, Elbers CC, Fang JC, Fox CS, Frackelton EC, Fuchs B, Furlong CE, Gibson Q, Gieger C, Goel A, Grobbee DE, Hastie C, Howard PJ, Huang GH, Johnson WC, Li Q, Kleber ME, Klein BE, Klein R, Kooperberg C, Ky B, Lacroix A, Lanken P, Lathrop M, Li M, Marshall V, Melander O, Mentch FD, Meyer NJ, Monda KL, Montpetit A, Murugesan G, Nakayama K, Nondahl D, Onipinla A, Rafelt S, Newhouse SJ, Otieno FG, Patel SR, Putt ME, Rodriguez S, Safa RN, Sawyer DB, Schreiner PJ, Simpson C, Sivapalaratnam S, Srinivasan SR, Suver C, Swergold G, Sweitzer NK, Thomas KA, Thorand B, Timpson NJ, Tischfield S, Tobin M, Tomaszewski M, Verschuren WM, Wallace C, Winkelmann B, Zhang H, Zheng D, Zhang L, Zmuda JM, Clarke R, Balmforth AJ, Danesh J, Day IN, Schork NJ, de Bakker PI, Delles C, Duggan D, Hingorani AD, Hirschhorn JN, Hofker MH, Humphries SE, Kivimaki M, Lawlor DA, Kottke-Marchant K, Mega JL, Mitchell BD, Morrow DA, Palmen J, Redline S, Shields DC, Shuldiner AR, Sleiman PM, Smith GD, Farrall M, Jamshidi Y, Christiani DC, Casas JP, Hall AS, Doevendans PA, Christie JD, Berenson GS, Murray SS, Illig T, Dorn GW 2nd, Cappola TP, Boerwinkle E, Sever P, Rader DJ, Reilly MP, Caulfield M, Talmud PJ, Topol E, Engert JC, Wang K, Dominiczak A, Hamsten A, Curtis SP, Silverstein RL, Lange LA, Sabatine MS, Trip M, Saleheen D, Peden JF, Cruickshanks KJ, März W, O'Connell JR, Klungel OH, Wijmenga C, Maitland-van der Zee AH, Schadt EE, Johnson JA, Jarvik GP, Papanicolaou GJ, Hugh Watkins on behalf of PROCARDIS, Grant SF, Munroe PB, North KE, Samani NJ, Koenig W, Gaunt TR, Anand SS, van der Schouw YT, Meena Kumari on behalf of the Whitehall II Study and the WHII 50K Group, Soranzo N, Fitzgerald GA, Reiner A, Hegele RA, Hakonarson H, Keating BJ) Am J Hum Genet 2011 Jan 07;88(1):6-18 PMID: 21194676 PMCID: PMC3014369 SCOPUS ID: 2-s2.0-78650904237 01/05/2011 105 Citations

A CD36-dependent pathway enhances macrophage and adipose tissue inflammation and impairs insulin signalling. (Kennedy DJ, Kuchibhotla S, Westfall KM, Silverstein RL, Morton RE, Febbraio M) Cardiovasc Res 2011 Feb 15;89(3):604-13 PMID: 21088116 PMCID: PMC3028977 SCOPUS ID: 2-s2.0-79551501139 11/23/2010 127 Citations

CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. (Li W, Febbraio M, Reddy SP, Yu DY, Yamamoto M, Silverstein RL) J Clin Invest 2010 Nov;120(11):3996-4006 PMID: 20978343 PMCID: PMC2964976 SCOPUS ID: 2-s2.0-78049420726 10/28/2010 103 Citations

A novel broadband impedance method for detection of cell-derived microparticles. (Lvovich V, Srikanthan S, Silverstein RL) Biosens Bioelectron 2010 Oct 15;26(2):444-51 PMID: 20729061 PMCID: PMC2946439 SCOPUS ID: 2-s2.0-77956895974 08/24/2010 22 Citations

Mechanisms of cell signaling by the scavenger receptor CD36: implications in atherosclerosis and thrombosis. (Silverstein RL, Li W, Park YM, Rahaman SO) Trans Am Clin Climatol Assoc 2010;121:206-20 PMID: 20697562 PMCID: PMC2917163 SCOPUS ID: 2-s2.0-78650419300 08/11/2010 137 Citations

Histidine-rich glycoprotein modulates the anti-angiogenic effects of vasculostatin. (Klenotic PA, Huang P, Palomo J, Kaur B, Van Meir EG, Vogelbaum MA, Febbraio M, Gladson CL, Silverstein RL) Am J Pathol 2010 Apr;176(4):2039-50 PMID: 20167858 PMCID: PMC2843491 SCOPUS ID: 2-s2.0-77950574193 02/20/2010 42 Citations

Type 2 scavenger receptor CD36 in platelet activation: the role of hyperlipemia and oxidative stress. (Silverstein RL) Clin Lipidol 2009 Dec;4(6):767 PMID: 20161667 PMCID: PMC2819200 SCOPUS ID: 2-s2.0-77649105407 02/18/2010 28 Citations

Lipid-induced insulin resistance is associated with increased monocyte expression of scavenger receptor CD36 and internalization of oxidized LDL. (Kashyap SR, Ioachimescu AG, Gornik HL, Gopan T, Davidson MB, Makdissi A, Major J, Febbraio M, Silverstein RL) Obesity (Silver Spring) 2009 Dec;17(12):2142-8 PMID: 19521352 PMCID: PMC2836489 SCOPUS ID: 2-s2.0-72449157475 06/13/2009 47 Citations

CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior. (Silverstein RL, Febbraio M) Sci Signal 2009 May 26;2(72):re3 PMID: 19471024 PMCID: PMC2811062 SCOPUS ID: 2-s2.0-67649216515 05/28/2009 705 Citations

Inflammation, atherosclerosis, and arterial thrombosis: role of the scavenger receptor CD36. (Silverstein RL) Cleve Clin J Med 2009 Apr;76 Suppl 2(Suppl 2):S27-30 PMID: 19376978 PMCID: PMC2810530 SCOPUS ID: 2-s2.0-67650735607 04/25/2009 98 Citations

TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis. (Drage MG, Pecora ND, Hise AG, Febbraio M, Silverstein RL, Golenbock DT, Boom WH, Harding CV) Cell Immunol 2009;258(1):29-37 PMID: 19362712 PMCID: PMC2730726 SCOPUS ID: 2-s2.0-67349217383 04/14/2009 121 Citations

Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism. (Kaur B, Cork SM, Sandberg EM, Devi NS, Zhang Z, Klenotic PA, Febbraio M, Shim H, Mao H, Tucker-Burden C, Silverstein RL, Brat DJ, Olson JJ, Van Meir EG) Cancer Res 2009 Feb 01;69(3):1212-20 PMID: 19176395 PMCID: PMC2659670 SCOPUS ID: 2-s2.0-59149099562 01/30/2009 89 Citations

CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima. (Park YM, Febbraio M, Silverstein RL) J Clin Invest 2009 Jan;119(1):136-45 PMID: 19065049 PMCID: PMC2613464 SCOPUS ID: 2-s2.0-61749103652 12/10/2008 278 Citations

Biological surgery: synergetic angiogenic therapy using coadministration of two progenitor cell populations. (Li W, Silverstein RL) Circ Res 2008 Sep 26;103(7):684-6 PMID: 18818411 PMCID: PMC2777677 SCOPUS ID: 2-s2.0-54449084122 09/27/2008

Thrombospondin-1-induced apoptosis of brain microvascular endothelial cells can be mediated by TNF-R1. (Rege TA, Stewart J Jr, Dranka B, Benveniste EN, Silverstein RL, Gladson CL) J Cell Physiol 2009 Jan;218(1):94-103 PMID: 18726995 PMCID: PMC2597846 SCOPUS ID: 2-s2.0-58649096802 08/30/2008 38 Citations

Deficiency of LRP8 in mice is associated with altered platelet function and prolonged time for in vivo thrombosis. (Robertson JO, Li W, Silverstein RL, Topol EJ, Smith JD) Thromb Res 2009 Feb;123(4):644-52 PMID: 18706682 PMCID: PMC2661626 SCOPUS ID: 2-s2.0-58649099165 08/19/2008 22 Citations

A specific CD36-dependent signaling pathway is required for platelet activation by oxidized low-density lipoprotein. (Chen K, Febbraio M, Li W, Silverstein RL) Circ Res 2008 Jun 20;102(12):1512-9 PMID: 18497330 PMCID: PMC2749986 SCOPUS ID: 2-s2.0-48249139826 05/24/2008 140 Citations

Platelet CD36 mediates interactions with endothelial cell-derived microparticles and contributes to thrombosis in mice. (Ghosh A, Li W, Febbraio M, Espinola RG, McCrae KR, Cockrell E, Silverstein RL) J Clin Invest 2008 May;118(5):1934-43 PMID: 18431509 PMCID: PMC2323190 SCOPUS ID: 2-s2.0-43049090815 04/24/2008 135 Citations

Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis. (Zhou J, Febbraio M, Wada T, Zhai Y, Kuruba R, He J, Lee JH, Khadem S, Ren S, Li S, Silverstein RL, Xie W) Gastroenterology 2008 Feb;134(2):556-67 PMID: 18242221 SCOPUS ID: 2-s2.0-38649096259 02/05/2008 443 Citations

CD36-TSP-HRGP interactions in the regulation of angiogenesis. (Silverstein RL, Febbraio M) Curr Pharm Des 2007;13(35):3559-67 PMID: 18220792 SCOPUS ID: 2-s2.0-36949022250 01/29/2008 34 Citations

Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1. (Chung EY, Liu J, Homma Y, Zhang Y, Brendolan A, Saggese M, Han J, Silverstein R, Selleri L, Ma X) Immunity 2007 Dec;27(6):952-64 PMID: 18093541 PMCID: PMC2194654 SCOPUS ID: 2-s2.0-37049031230 12/21/2007 178 Citations

Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype. (Podrez EA, Byzova TV, Febbraio M, Salomon RG, Ma Y, Valiyaveettil M, Poliakov E, Sun M, Finton PJ, Curtis BR, Chen J, Zhang R, Silverstein RL, Hazen SL) Nat Med 2007 Sep;13(9):1086-95 PMID: 17721545 PMCID: PMC3042888 SCOPUS ID: 2-s2.0-34948882706 08/28/2007 363 Citations

Venous thrombosis in the elderly: more questions than answers. (Silverstein RL, Bauer KA, Cushman M, Esmon CT, Ershler WB, Tracy RP) Blood 2007 Nov 01;110(9):3097-101 PMID: 17684155 SCOPUS ID: 2-s2.0-36148959725 08/09/2007 67 Citations

CD36: implications in cardiovascular disease. (Febbraio M, Silverstein RL) Int J Biochem Cell Biol 2007;39(11):2012-30 PMID: 17466567 PMCID: PMC2034445 SCOPUS ID: 2-s2.0-34548482011 05/01/2007 196 Citations

Oxidized phosphatidylserine-CD36 interactions play an essential role in macrophage-dependent phagocytosis of apoptotic cells. (Greenberg ME, Sun M, Zhang R, Febbraio M, Silverstein R, Hazen SL) J Exp Med 2006 Nov 27;203(12):2613-25 PMID: 17101731 PMCID: PMC2118161 SCOPUS ID: 2-s2.0-33751519372 11/15/2006 317 Citations

A CD36-dependent signaling cascade is necessary for macrophage foam cell formation. (Rahaman SO, Lennon DJ, Febbraio M, Podrez EA, Hazen SL, Silverstein RL) Cell Metab 2006 Sep;4(3):211-21 PMID: 16950138 PMCID: PMC1855263 SCOPUS ID: 2-s2.0-33747859314 09/05/2006 377 Citations

Requirements for apoptotic cell contact in regulation of macrophage responses. (Lucas M, Stuart LM, Zhang A, Hodivala-Dilke K, Febbraio M, Silverstein R, Savill J, Lacy-Hulbert A) J Immunol 2006 Sep 15;177(6):4047-54 PMID: 16951368 SCOPUS ID: 2-s2.0-33748501056 09/05/2006 118 Citations

Neprilysin inhibits angiogenesis via proteolysis of fibroblast growth factor-2. (Goodman OB Jr, Febbraio M, Simantov R, Zheng R, Shen R, Silverstein RL, Nanus DM) J Biol Chem 2006 Nov 03;281(44):33597-605 PMID: 16940054 SCOPUS ID: 2-s2.0-33845963086 08/31/2006 40 Citations

Continued inhibition of atherosclerotic lesion development in long term Western diet fed CD36o /apoEo mice . (Guy E, Kuchibhotla S, Silverstein R, Febbraio M) Atherosclerosis 2007 May;192(1):123-30 PMID: 16919281 SCOPUS ID: 2-s2.0-34247172133 08/22/2006 60 Citations

Light-induced oxidation of photoreceptor outer segment phospholipids generates ligands for CD36-mediated phagocytosis by retinal pigment epithelium: a potential mechanism for modulating outer segment phagocytosis under oxidant stress conditions. (Sun M, Finnemann SC, Febbraio M, Shan L, Annangudi SP, Podrez EA, Hoppe G, Darrow R, Organisciak DT, Salomon RG, Silverstein RL, Hazen SL) J Biol Chem 2006 Feb 17;281(7):4222-30 PMID: 16354659 PMCID: PMC3627732 SCOPUS ID: 2-s2.0-33645228802 12/16/2005 123 Citations

EP 80317, a ligand of the CD36 scavenger receptor, protects apolipoprotein E-deficient mice from developing atherosclerotic lesions. (Marleau S, Harb D, Bujold K, Avallone R, Iken K, Wang Y, Demers A, Sirois MG, Febbraio M, Silverstein RL, Tremblay A, Ong H) FASEB J 2005 Nov;19(13):1869-71 PMID: 16123174 SCOPUS ID: 2-s2.0-27744467574 08/27/2005 97 Citations

A novel isoform of human Golgi complex-localized glycoprotein-1 (also known as E-selectin ligand-1, MG-160 and cysteine-rich fibroblast growth factor receptor) targets differential subcellular localization. (Ahn J, Febbraio M, Silverstein RL) J Cell Sci 2005 Apr 15;118(Pt 8):1725-31 PMID: 15797922 SCOPUS ID: 2-s2.0-18844389802 03/31/2005 17 Citations

The class B scavenger receptor CD36 mediates free radical production and tissue injury in cerebral ischemia. (Cho S, Park EM, Febbraio M, Anrather J, Park L, Racchumi G, Silverstein RL, Iadecola C) J Neurosci 2005 Mar 09;25(10):2504-12 PMID: 15758158 PMCID: PMC6725161 SCOPUS ID: 2-s2.0-14944379101 03/11/2005 172 Citations

The antiangiogenic effect of thrombospondin-2 is mediated by CD36 and modulated by histidine-rich glycoprotein. (Simantov R, Febbraio M, Silverstein RL) Matrix Biol 2005 Feb;24(1):27-34 PMID: 15748999 SCOPUS ID: 2-s2.0-14644433781 03/08/2005 87 Citations

Stem cell transplantation reveals that absence of macrophage CD36 is protective against atherosclerosis. (Febbraio M, Guy E, Silverstein RL) Arterioscler Thromb Vasc Biol 2004 Dec;24(12):2333-8 PMID: 15486305 SCOPUS ID: 2-s2.0-10644255811 10/16/2004 142 Citations

The second international congress on myeloproliferative and myelodysplastic syndromes. (Silver RT, Bennett JM, Deininger M, Feldman E, Rafii S, Silverstein RL, Solberg LA, Spivak JL) Leuk Res 2004 Sep;28(9):979-85 PMID: 15234576 SCOPUS ID: 2-s2.0-3242723014 07/06/2004 6 Citations

Identification of the growth hormone-releasing peptide binding site in CD36: a photoaffinity cross-linking study. (Demers A, McNicoll N, Febbraio M, Servant M, Marleau S, Silverstein R, Ong H) Biochem J 2004 Sep 01;382(Pt 2):417-24 PMID: 15176951 PMCID: PMC1133797 SCOPUS ID: 2-s2.0-4544363024 06/05/2004 90 Citations

CD36 mediates the phagocytosis of Plasmodium falciparum-infected erythrocytes by rodent macrophages. (Patel SN, Serghides L, Smith TG, Febbraio M, Silverstein RL, Kurtz TW, Pravenec M, Kain KC) J Infect Dis 2004 Jan 15;189(2):204-13 PMID: 14722884 SCOPUS ID: 2-s2.0-0742324946 01/15/2004 103 Citations

Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo. (Ling Q, Jacovina AT, Deora A, Febbraio M, Simantov R, Silverstein RL, Hempstead B, Mark WH, Hajjar KA) J Clin Invest 2004 Jan;113(1):38-48 PMID: 14702107 PMCID: PMC300771 SCOPUS ID: 2-s2.0-1542466792 01/01/2004 320 Citations

CD36: a critical anti-angiogenic receptor. (Simantov R, Silverstein RL) Front Biosci 2003 Sep 01;8:s874-82 PMID: 12957861 SCOPUS ID: 2-s2.0-4344701559 09/06/2003 63 Citations

Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/ KDR. (Bais C, Van Geelen A, Eroles P, Mutlu A, Chiozzini C, Dias S, Silverstein RL, Rafii S, Mesri EA) Cancer Cell 2003 Feb;3(2):131-43 PMID: 12620408 SCOPUS ID: 2-s2.0-0142213135 03/07/2003 208 Citations

CD36-mediated nonopsonic phagocytosis of erythrocytes infected with stage I and IIA gametocytes of Plasmodium falciparum. (Smith TG, Serghides L, Patel SN, Febbraio M, Silverstein RL, Kain KC) Infect Immun 2003 Jan;71(1):393-400 PMID: 12496189 PMCID: PMC143147 SCOPUS ID: 2-s2.0-0037220515 12/24/2002 56 Citations

The impact of overexpression and deficiency of fatty acid translocase (FAT)/CD36. (Febbraio M, Guy E, Coburn C, Knapp FF Jr, Beets AL, Abumrad NA, Silverstein RL) Mol Cell Biochem 2002 Oct;239(1-2):193-7 PMID: 12479585 SCOPUS ID: 2-s2.0-0036813391 12/14/2002 71 Citations

The face of TSR revealed: an extracellular signaling domain is exposed. (Silverstein RL) J Cell Biol 2002 Oct 28;159(2):203-6 PMID: 12403807 PMCID: PMC2173053 SCOPUS ID: 2-s2.0-0037191044 10/31/2002 30 Citations

Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. (Kunjathoor VV, Febbraio M, Podrez EA, Moore KJ, Andersson L, Koehn S, Rhee JS, Silverstein R, Hoff HF, Freeman MW) J Biol Chem 2002 Dec 20;277(51):49982-8 PMID: 12376530 SCOPUS ID: 2-s2.0-0346037268 10/12/2002 758 Citations

A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions. (Podrez EA, Poliakov E, Shen Z, Zhang R, Deng Y, Sun M, Finton PJ, Shan L, Febbraio M, Hajjar DP, Silverstein RL, Hoff HF, Salomon RG, Hazen SL) J Biol Chem 2002 Oct 11;277(41):38517-23 PMID: 12145296 SCOPUS ID: 2-s2.0-0037064036 07/30/2002 328 Citations

CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart. (Bodart V, Febbraio M, Demers A, McNicoll N, Pohankova P, Perreault A, Sejlitz T, Escher E, Silverstein RL, Lamontagne D, Ong H) Circ Res 2002 May 03;90(8):844-9 PMID: 11988484 SCOPUS ID: 2-s2.0-0037013178 05/04/2002 144 Citations

Hematology grants workshop-2001. (Todd RF 3rd, Miller DM, Silverstein RL) Hematology Am Soc Hematol Educ Program 2001:507-21 PMID: 11723002 SCOPUS ID: 2-s2.0-0035225570 11/28/2001 2 Citations

Structural and functional characterization of the mouse fatty acid translocase promoter: activation during adipose differentiation. (Teboul L, Febbraio M, Gaillard D, Amri EZ, Silverstein R, Grimaldi PA) Biochem J 2001 Dec 01;360(Pt 2):305-12 PMID: 11716758 PMCID: PMC1222230 SCOPUS ID: 2-s2.0-0035625679 11/22/2001 67 Citations

Hematology Grants Workshop-2000. (Todd RF 3rd, Miller DM, Silverstein RL) Hematology Am Soc Hematol Educ Program 2000:424-437 PMID: 11701555 11/10/2001

Differential roles of CD36 and alphavbeta5 integrin in photoreceptor phagocytosis by the retinal pigment epithelium. (Finnemann SC, Silverstein RL) J Exp Med 2001 Nov 05;194(9):1289-98 PMID: 11696594 PMCID: PMC2195987 SCOPUS ID: 2-s2.0-0035172341 11/07/2001 111 Citations

CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism. (Febbraio M, Hajjar DP, Silverstein RL) J Clin Invest 2001 Sep;108(6):785-91 PMID: 11560944 PMCID: PMC200943 SCOPUS ID: 2-s2.0-0034833822 09/19/2001 925 Citations

Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1. (Simantov R, Febbraio M, Crombie R, Asch AS, Nachman RL, Silverstein RL) J Clin Invest 2001 Jan;107(1):45-52 PMID: 11134179 PMCID: PMC198540 SCOPUS ID: 2-s2.0-0035171206 01/03/2001 92 Citations

Gene expression of oxidized low density lipoprotein treated macrophages mediated by class b scavenger receptor, CD36 (Winder A, Febbraio M, Silverstein RL) Blood 2000;96(11 PART II) SCOPUS ID: 2-s2.0-33748521274 12/01/2000

Histidine rich glycoprotein (hrgp) inhibits the angiostatic activity of thrombospondin-1 (tsp-1) in vtvo (Simantov R, Febbraio M, Nachman RL, Crombie R, Silverstein RL) Blood 2000;96(11 PART I) SCOPUS ID: 2-s2.0-33748645579 12/01/2000

Erythropoiesis is enhanced in CD36 deficient mice (Heissig B, Hattori K, Moore MAS, Rafii S, Silverstein R, Febbraio M) Blood 2000;96(11 PART I) SCOPUS ID: 2-s2.0-33748670563 12/01/2000 1 Citation

CD36 and atherosclerosis. (Silverstein RL, Febbraio M) Curr Opin Lipidol 2000 Oct;11(5):483-91 PMID: 11048891 SCOPUS ID: 2-s2.0-0033775657 10/26/2000 108 Citations

A CD36 synthetic peptide inhibits bleomycin-induced pulmonary inflammation and connective tissue synthesis in the rat. (Yehualaeshet T, O'Connor R, Begleiter A, Murphy-Ullrich JE, Silverstein R, Khalil N) Am J Respir Cell Mol Biol 2000 Aug;23(2):204-12 PMID: 10919987 SCOPUS ID: 2-s2.0-0033844731 08/02/2000 68 Citations

Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice. (Coburn CT, Knapp FF Jr, Febbraio M, Beets AL, Silverstein RL, Abumrad NA) J Biol Chem 2000 Oct 20;275(42):32523-9 PMID: 10913136 SCOPUS ID: 2-s2.0-0034693232 07/27/2000 521 Citations

CD36 in atherosclerosis. The role of a class B macrophage scavenger receptor. (Nicholson AC, Febbraio M, Han J, Silverstein RL, Hajjar DP) Ann N Y Acad Sci 2000 May;902:128-31; discussion 131-3 PMID: 10865832 SCOPUS ID: 2-s2.0-0034081958 06/24/2000 64 Citations

High affinity binding of beta 2-glycoprotein I to human endothelial cells is mediated by annexin II. (Ma K, Simantov R, Zhang JC, Silverstein R, Hajjar KA, McCrae KR) J Biol Chem 2000 May 19;275(20):15541-8 PMID: 10809787 SCOPUS ID: 2-s2.0-0034685886 05/16/2000 207 Citations

Induction of CD36 expression by oxidized LDL and IL-4 by a common signaling pathway dependent on protein kinase C and PPAR-gamma. (Feng J, Han J, Pearce SF, Silverstein RL, Gotto AM Jr, Hajjar DP, Nicholson AC) J Lipid Res 2000 May;41(5):688-96 PMID: 10787429 SCOPUS ID: 2-s2.0-0034123963 04/29/2000 212 Citations

Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species. (Podrez EA, Febbraio M, Sheibani N, Schmitt D, Silverstein RL, Hajjar DP, Cohen PA, Frazier WA, Hoff HF, Hazen SL) J Clin Invest 2000 Apr;105(8):1095-108 PMID: 10772654 PMCID: PMC300829 SCOPUS ID: 2-s2.0-0034051080 04/20/2000 362 Citations

Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice. (Febbraio M, Podrez EA, Smith JD, Hajjar DP, Hazen SL, Hoff HF, Sharma K, Silverstein RL) J Clin Invest 2000 Apr;105(8):1049-56 PMID: 10772649 PMCID: PMC300837 SCOPUS ID: 2-s2.0-0034101821 04/20/2000 823 Citations

Erratum: Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species (Journal of Clinical Investigation (2000) 105 (1095-1108)) (Podrez EA, Febbraio M, Sheibani N, Schmitt D, Silverstein RL, Hajjar DP, Cohen PA, Frazier WA, Hoff HF, Hazen SL) Journal of Clinical Investigation 2000;105(10):1483 SCOPUS ID: 2-s2.0-0034072745 01/01/2000 3 Citations

Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1. (Jiménez B, Volpert OV, Crawford SE, Febbraio M, Silverstein RL, Bouck N) Nat Med 2000 Jan;6(1):41-8 PMID: 10613822 SCOPUS ID: 2-s2.0-0342445431 12/29/1999 850 Citations

Stromal derived factor-1-induced chemokinesis of cord blood CD34(+) cells (long-term culture-initiating cells) through endothelial cells is mediated by E-selectin. (Naiyer AJ, Jo DY, Ahn J, Mohle R, Peichev M, Lam G, Silverstein RL, Moore MA, Rafii S) Blood 1999 Dec 15;94(12):4011-9 PMID: 10590044 SCOPUS ID: 2-s2.0-0032794412 12/10/1999 90 Citations

Activation of rat alveolar macrophage-derived latent transforming growth factor beta-1 by plasmin requires interaction with thrombospondin-1 and its cell surface receptor, CD36. (Yehualaeshet T, O'Connor R, Green-Johnson J, Mai S, Silverstein R, Murphy-Ullrich JE, Khalil N) Am J Pathol 1999 Sep;155(3):841-51 PMID: 10487979 PMCID: PMC1866879 SCOPUS ID: 2-s2.0-0032886794 09/17/1999 152 Citations

Angiogenesis and atherosclerosis. The mandate broadens. (Silverstein RL, Nachman RL) Circulation 1999 Aug 24;100(8):783-5 PMID: 10458710 SCOPUS ID: 2-s2.0-0033600531 08/24/1999 20 Citations

A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism. (Febbraio M, Abumrad NA, Hajjar DP, Sharma K, Cheng W, Pearce SF, Silverstein RL) J Biol Chem 1999 Jul 02;274(27):19055-62 PMID: 10383407 SCOPUS ID: 2-s2.0-0033516477 06/26/1999 654 Citations

Retinoic acid alters the mechanism of attachment of malignant astrocytoma and neuroblastoma cells to thrombospondin-1. (Pijuan-Thompson V, Grammer JR, Stewart J, Silverstein RL, Pearce SF, Tuszynski GP, Murphy-Ullrich JE, Gladson CL) Exp Cell Res 1999 May 25;249(1):86-101 PMID: 10328956 SCOPUS ID: 2-s2.0-0033602741 05/18/1999 37 Citations

Three distinct D-amino acid substitutions confer potent antiangiogenic activity on an inactive peptide derived from a thrombospondin-1 type 1 repeat. (Dawson DW, Volpert OV, Pearce SF, Schneider AJ, Silverstein RL, Henkin J, Bouck NP) Mol Pharmacol 1999 Feb;55(2):332-8 PMID: 9927626 SCOPUS ID: 2-s2.0-0033027727 02/03/1999 134 Citations

Recombinant glutathione S-transferase/CD36 fusion proteins define an oxidized low density lipoprotein-binding domain. (Pearce SF, Roy P, Nicholson AC, Hajjar DP, Febbraio M, Silverstein RL) J Biol Chem 1998 Dec 25;273(52):34875-81 PMID: 9857015 SCOPUS ID: 2-s2.0-0032567491 12/18/1998 53 Citations

Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. (Albert ML, Pearce SF, Francisco LM, Sauter B, Roy P, Silverstein RL, Bhardwaj N) J Exp Med 1998 Oct 05;188(7):1359-68 PMID: 9763615 PMCID: PMC2212488 SCOPUS ID: 2-s2.0-3543053363 10/09/1998 1062 Citations

CD36 mediates binding of soluble thrombospondin-1 but not cell adhesion and haptotaxis on immobilized thrombospondin-1. (Magnetto S, Bruno-Bossio G, Voland C, Lecerf J, Lawler J, Delmas P, Silverstein R, Clezardin P) Cell Biochem Funct 1998 Sep;16(3):211-21 PMID: 9747513 SCOPUS ID: 2-s2.0-0031710790 09/25/1998 17 Citations

Cell adhesion molecules: an overview. (Joseph-Silverstein J, Silverstein RL) Cancer Invest 1998;16(3):176-82 PMID: 9541632 SCOPUS ID: 2-s2.0-0031919852 04/29/1998 46 Citations

Lysosomal integral membrane protein II binds thrombospondin-1. Structure-function homology with the cell adhesion molecule CD36 defines a conserved recognition motif. (Crombie R, Silverstein R) J Biol Chem 1998 Feb 27;273(9):4855-63 PMID: 9478926 SCOPUS ID: 2-s2.0-0032570699 03/28/1998 54 Citations

Identification of a CD36-related thrombospondin 1-binding domain in HIV-1 envelope glycoprotein gp120: relationship to HIV-1-specific inhibitory factors in human saliva. (Crombie R, Silverstein RL, MacLow C, Pearce SF, Nachman RL, Laurence J) J Exp Med 1998 Jan 05;187(1):25-35 PMID: 9419208 PMCID: PMC2199189 SCOPUS ID: 2-s2.0-0031983724 01/31/1998 75 Citations

Introduction (Silverstein RL) Cancer Investigation 1998;16(3):175 SCOPUS ID: 2-s2.0-0031897047 01/01/1998

Anticardiolipin IgG subclasses: association of IgG2 with arterial and/or venous thrombosis. (Sammaritano LR, Ng S, Sobel R, Lo SK, Simantov R, Furie R, Kaell A, Silverstein R, Salmon JE) Arthritis Rheum 1997 Nov;40(11):1998-2006 PMID: 9365089 SCOPUS ID: 2-s2.0-0030784716 11/19/1997 91 Citations

CD36 mediates the In vitro inhibitory effects of thrombospondin-1 on endothelial cells. (Dawson DW, Pearce SF, Zhong R, Silverstein RL, Frazier WA, Bouck NP) J Cell Biol 1997 Aug 11;138(3):707-17 PMID: 9245797 PMCID: PMC2141641 SCOPUS ID: 2-s2.0-0030833817 08/11/1997 544 Citations

CD36 expression is altered in retinal pigment epithelial cells of the RCS rat. (Sparrow JR, Ryeom SW, Abumrad NA, Ibrahimi A, Silverstein RL) Exp Eye Res 1997 Jan;64(1):45-56 PMID: 9093020 SCOPUS ID: 2-s2.0-0031029850 01/01/1997 20 Citations

Engagement of the Lewis X antigen (CD15) results in monocyte activation. (Lo SK, Golenbock DT, Sass PM, Maskati A, Xu H, Silverstein RL) Blood 1997 Jan 01;89(1):307-14 PMID: 8978306 SCOPUS ID: 2-s2.0-0031019583 01/01/1997 36 Citations

Factor V Leiden increases the risk of thrombosis in patients with antiphospholipid antibodies. (Simantov R, Lo SK, Salmon JE, Sammaritano LR, Silverstein RL) Thromb Res 1996 Dec 01;84(5):361-5 PMID: 8948063 SCOPUS ID: 2-s2.0-0030561510 12/01/1996 32 Citations

Antiphospholipid antibodies activate vascular endothelial cells. (Simantov R, Lo SK, Gharavi A, Sammaritano LR, Salmon JE, Silverstein RL) Lupus 1996 Oct;5(5):440-1 PMID: 8902777 SCOPUS ID: 2-s2.0-0029845565 10/01/1996 44 Citations

Binding of anionic phospholipids to retinal pigment epithelium may be mediated by the scavenger receptor CD36. (Ryeom SW, Silverstein RL, Scotto A, Sparrow JR) J Biol Chem 1996 Aug 23;271(34):20536-9 PMID: 8702796 SCOPUS ID: 2-s2.0-0029786328 08/23/1996 126 Citations

Regulation of monocyte CD36 and thrombospondin-1 expression by soluble mediators. (Yesner LM, Huh HY, Pearce SF, Silverstein RL) Arterioscler Thromb Vasc Biol 1996 Aug;16(8):1019-25 PMID: 8696941 SCOPUS ID: 2-s2.0-0007827969 08/01/1996 151 Citations

Hypercoagulability in cancer. (Green KB, Silverstein RL) Hematol Oncol Clin North Am 1996 Apr;10(2):499-530 PMID: 8707766 SCOPUS ID: 2-s2.0-0029980575 04/01/1996 150 Citations

Regulated expression of CD36 during monocyte-to-macrophage differentiation: potential role of CD36 in foam cell formation. (Huh HY, Pearce SF, Yesner LM, Schindler JL, Silverstein RL) Blood 1996 Mar 01;87(5):2020-8 PMID: 8634453 SCOPUS ID: 2-s2.0-0000685254 03/01/1996 232 Citations

Photoreceptor Outer Segment (ROS) interactions with CD36: Structure/function relationships (Ryeom SW, Sparrow JR, Silverstein RL) Investigative Ophthalmology and Visual Science 15 February 1996;37(3) SCOPUS ID: 2-s2.0-0010271922 02/15/1996 1 Citation

CD36 participates in the phagocytosis of rod outer segments by retinal pigment epithelium. (Ryeom SW, Sparrow JR, Silverstein RL) J Cell Sci 1996 Feb;109 ( Pt 2):387-95 PMID: 8838662 SCOPUS ID: 2-s2.0-0030022233 02/01/1996 181 Citations

Monocyte cd36 induction by e-selectin tethering: Role of eselectin ligand-1 and protein kinase c in signalling (Huh HY, Lo SK, Silverstein RL) Journal of Investigative Medicine 1996;44(3) SCOPUS ID: 2-s2.0-33749446638 01/01/1996

Factor V Leiden increases the risk of thrombosis in patients with antiphospholipid antibodies (Simantov R, Lo SK, Salmon JE, Sammaritano LR, Silverstein RL) Journal of Investigative Medicine 1996;44(3) SCOPUS ID: 2-s2.0-33749425104 01/01/1996

Activation of cultured vascular endothelial cells by antiphospholipid antibodies. (Simantov R, LaSala JM, Lo SK, Gharavi AE, Sammaritano LR, Salmon JE, Silverstein RL) J Clin Invest 1995 Nov;96(5):2211-9 PMID: 7593607 PMCID: PMC185871 SCOPUS ID: 2-s2.0-0028883356 11/01/1995 382 Citations

Thrombosis and inflammation as multicellular processes: significance of cell-cell interactions. (Marcus AJ, Safier LB, Broekman MJ, Islam N, Fliessbach JH, Hajjar KA, Kaminski WE, Jendraschak E, Silverstein RL, von Schacky C) Thromb Haemost 1995 Jul;74(1):213-7 PMID: 8578460 SCOPUS ID: 2-s2.0-0029093011 07/01/1995 70 Citations

CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis. (Ren Y, Silverstein RL, Allen J, Savill J) J Exp Med 1995 May 01;181(5):1857-62 PMID: 7536797 PMCID: PMC2192004 SCOPUS ID: 2-s2.0-0028917593 05/01/1995 349 Citations

Induction of tissue factor on monocytes by adhesion to endothelial cells. (Lo SK, Cheung A, Zheng Q, Silverstein RL) J Immunol 1995 May 01;154(9):4768-77 PMID: 7536780 SCOPUS ID: 2-s2.0-0029008242 05/01/1995 91 Citations

CD36 induction on human monocytes upon adhesion to tumor necrosis factor-activated endothelial cells. (Huh HY, Lo SK, Yesner LM, Silverstein RL) J Biol Chem 1995 Mar 17;270(11):6267-71 PMID: 7534309 SCOPUS ID: 2-s2.0-0028902817 03/17/1995 51 Citations

Recombinant GST/CD36 fusion proteins define a thrombospondin binding domain. Evidence for a single calcium-dependent binding site on CD36. (Frieda S, Pearce A, Wu J, Silverstein RL) J Biol Chem 1995 Feb 17;270(7):2981-6 PMID: 7531696 SCOPUS ID: 2-s2.0-0028854921 02/17/1995 79 Citations

Oxidized LDL binds to CD36 on human monocyte-derived macrophages and transfected cell lines. Evidence implicating the lipid moiety of the lipoprotein as the binding site. (Nicholson AC, Frieda S, Pearce A, Silverstein RL) Arterioscler Thromb Vasc Biol 1995 Feb;15(2):269-75 PMID: 7538425 SCOPUS ID: 2-s2.0-0028963942 02/01/1995 222 Citations

Principles of thromboregulation: control of platelet reactivity in vascular disease. (Marcus AJ, Safier LB, Kaminski WE, Islam N, Hajjar KA, Jendraschak E, Silverstein RL, Broekman MJ, von Schacky C, Fliessbach JH) Adv Prostaglandin Thromboxane Leukot Res 1995;23:413-8 PMID: 7732885 SCOPUS ID: 2-s2.0-0029193420 01/01/1995 7 Citations

A carboxyl terminal truncation mutant of CD36 is secreted and binds thrombospondin: evidence for a single transmembrane domain. (Pearce SF, Wu J, Silverstein RL) Blood 1994 Jul 15;84(2):384-9 PMID: 7517712 SCOPUS ID: 2-s2.0-0028182582 07/15/1994 57 Citations

Hypercoagulability after hip and knee replacement. (Disla E) Ann Intern Med 1994 Mar 15;120(6):523 PMID: 8311379 SCOPUS ID: 2-s2.0-0028349943 03/15/1994

CD antigens 1993. (Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein RL, Springer TA) Immunol Today 1994 Mar;15(3):98-9 PMID: 7909665 SCOPUS ID: 2-s2.0-43949152360 03/01/1994 6 Citations

CD antigens 1993. (Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein RL, Springer TA) Blood 1994 Feb 15;83(4):879-80 PMID: 8111060 SCOPUS ID: 2-s2.0-0028012742 02/15/1994 29 Citations

CD antigens 1993. (Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein RL, Springer TA) J Immunol 1994 Jan 01;152(1):1-2 PMID: 7902854 SCOPUS ID: 2-s2.0-0028156612 01/01/1994 26 Citations

Hypercoagulable states. (Nachman RL, Silverstein R) Ann Intern Med 1993 Oct 15;119(8):819-27 PMID: 8379603 SCOPUS ID: 2-s2.0-0027729107 10/15/1993 192 Citations

von Willebrand factor mediates platelet adhesion to virally infected endothelial cells. (Etingin OR, Silverstein RL, Hajjar DP) Proc Natl Acad Sci U S A 1993 Jun 01;90(11):5153-6 PMID: 8389471 PMCID: PMC46673 SCOPUS ID: 2-s2.0-0027265214 06/01/1993 67 Citations

Activated platelets form protected zones of adhesion on fibrinogen and fibronectin-coated surfaces. (Loike JD, Silverstein R, Cao L, Solomon L, Weitz J, Haber E, Matsueda GR, Bernatowicz MS, Silverstein SC) J Cell Biol 1993 May;121(4):945-55 PMID: 8491785 PMCID: PMC2119798 SCOPUS ID: 2-s2.0-0027262210 05/01/1993 15 Citations

Venous thrombosis and cancer. (O'Connor N) N Engl J Med 1993 Mar 25;328(12):885-6; author reply 886-7 PMID: 8441438 SCOPUS ID: 2-s2.0-0027404708 03/25/1993 11 Citations

The role of protected extracellular compartments in interactions between leukocytes, and platelets, and fibrin/fibrinogen matrices. (Loike JD, Silverstein R, Wright SD, Weitz JI, Huang AJ, Silverstein SC) Ann N Y Acad Sci 1992 Dec 04;667:163-72 PMID: 1309032 SCOPUS ID: 2-s2.0-0027052126 12/04/1992 49 Citations

Cancer and clotting--Trousseau's warning. (Silverstein RL, Nachman RL) N Engl J Med 1992 Oct 15;327(16):1163-4 PMID: 1308758 SCOPUS ID: 2-s2.0-0026737349 10/15/1992 50 Citations

Identification of lysosome-associated membrane protein-2 as an activation-dependent platelet surface glycoprotein. (Silverstein RL, Febbraio M) Blood 1992 Sep 15;80(6):1470-5 PMID: 1520873 SCOPUS ID: 2-s2.0-0026778775 09/15/1992 77 Citations

Sense and antisense cDNA transfection of CD36 (glycoprotein IV) in melanoma cells. Role of CD36 as a thrombospondin receptor. (Silverstein RL, Baird M, Lo SK, Yesner LM) J Biol Chem 1992 Aug 15;267(23):16607-12 PMID: 1379600 SCOPUS ID: 2-s2.0-0026706684 08/15/1992 78 Citations

Identification of a monocyte receptor on herpesvirus-infected endothelial cells. (Etingin OR, Silverstein RL, Hajjar DP) Proc Natl Acad Sci U S A 1991 Aug 15;88(16):7200-3 PMID: 1714592 PMCID: PMC52261 SCOPUS ID: 2-s2.0-0025834414 08/15/1991 64 Citations

CD36-mediated signal transduction in human monocytes by anti-CD36 antibodies but not by anti-thrombospondin antibodies recognizing cell membrane-bound thrombospondin. (Schüepp BJ, Pfister H, Clemetson KJ, Silverstein RL, Jungi TW) Biochem Biophys Res Commun 1991 Feb 28;175(1):263-70 PMID: 1998511 SCOPUS ID: 2-s2.0-0026029480 02/28/1991 33 Citations

Identification and characterization of LAMP-1 as an activation-dependent platelet surface glycoprotein. (Febbraio M, Silverstein RL) J Biol Chem 1990 Oct 25;265(30):18531-7 PMID: 2211717 SCOPUS ID: 2-s2.0-0025133326 10/25/1990 78 Citations

Erratum: Thrombospondin forms complexes with single-chain and two-chain forms of urokinase (Vol. 265 (1990) 11289-11294) (Silverstein RL, Nachman RL, Pannell R, Gurewich V, Harpel PC) Journal of Biological Chemistry 1990;265(26):16025 SCOPUS ID: 2-s2.0-0024988573 10/11/1990

Thrombospondin forms complexes with single-chain and two-chain forms of urokinase. (Silverstein RL, Nachman RL, Pannell R, Gurewich V, Harpel PC) J Biol Chem 1990 Jul 05;265(19):11289-94 PMID: 2141608 SCOPUS ID: 2-s2.0-0025331427 07/05/1990 38 Citations

Viral activation of the coagulation cascade: molecular interactions at the surface of infected endothelial cells. (Etingin OR, Silverstein RL, Friedman HM, Hajjar DP) Cell 1990 May 18;61(4):657-62 PMID: 2160855 SCOPUS ID: 2-s2.0-0025277749 05/18/1990 98 Citations

Glycoprotein IV mediates thrombospondin-dependent platelet-monocyte and platelet-U937 cell adhesion. (Silverstein RL, Asch AS, Nachman RL) J Clin Invest 1989 Aug;84(2):546-52 PMID: 2474571 PMCID: PMC548914 SCOPUS ID: 2-s2.0-0024335931 08/01/1989 155 Citations

Binding of Lys-plasminogen to monocytes/macrophages. (Silverstein RL, Friedlander RJ Jr, Nicholas RL, Nachman RL) J Clin Invest 1988 Dec;82(6):1948-55 PMID: 2974046 PMCID: PMC442776 SCOPUS ID: 2-s2.0-0024255824 12/01/1988 39 Citations

Tumor necrosis factor-mediated release of platelet-derived growth factor from cultured endothelial cells. (Hajjar KA, Hajjar DP, Silverstein RL, Nachman RL) J Exp Med 1987 Jul 01;166(1):235-45 PMID: 3598461 PMCID: PMC2188629 SCOPUS ID: 2-s2.0-0023257296 07/01/1987 140 Citations

Thrombospondin-plasminogen interactions: modulation of plasmin generation. (Silverstein RL, Nachman RL) Semin Thromb Hemost 1987 Jul;13(3):335-42 PMID: 2961063 SCOPUS ID: 2-s2.0-0023376749 07/01/1987 12 Citations

Isolation of the thrombospondin membrane receptor. (Asch AS, Barnwell J, Silverstein RL, Nachman RL) J Clin Invest 1987 Apr;79(4):1054-61 PMID: 2435757 PMCID: PMC424283 SCOPUS ID: 2-s2.0-0023251127 04/01/1987 368 Citations

Thrombospondin binds to monocytes-macrophages and mediates platelet-monocyte adhesion. (Silverstein RL, Nachman RL) J Clin Invest 1987 Mar;79(3):867-74 PMID: 3818952 PMCID: PMC424223 SCOPUS ID: 2-s2.0-0023126677 03/01/1987 79 Citations

Binding of plasminogen to extracellular matrix. (Knudsen BS, Silverstein RL, Leung LL, Harpel PC, Nachman RL) J Biol Chem 1986 Aug 15;261(23):10765-71 PMID: 3090040 SCOPUS ID: 2-s2.0-0022969199 08/15/1986 131 Citations

Tissue plasminogen activator and urokinase enhance the binding of plasminogen to thrombospondin. (Silverstein RL, Harpel PC, Nachman RL) J Biol Chem 1986 Jul 25;261(21):9959-65 PMID: 2942536 SCOPUS ID: 2-s2.0-0023028858 07/25/1986 29 Citations

Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor. (Nachman RL, Hajjar KA, Silverstein RL, Dinarello CA) J Exp Med 1986 Jun 01;163(6):1595-600 PMID: 3086483 PMCID: PMC2188126 SCOPUS ID: 2-s2.0-0022517446 06/01/1986 222 Citations

Thrombospondin: a versatile multifunctional glycoprotein. (Silverstein RL, Leung LL, Nachman RL) Arteriosclerosis 1986;6(3):245-53 PMID: 3518684 SCOPUS ID: 2-s2.0-0022448462 05/01/1986 42 Citations

Activation of immobilized plasminogen by tissue activator. Multimolecular complex formation. (Silverstein RL, Nachman RL, Leung LL, Harpel PC) J Biol Chem 1985 Aug 25;260(18):10346-52 PMID: 3160707 SCOPUS ID: 2-s2.0-0022376430 08/25/1985 79 Citations

Platelet thrombospondin forms a trimolecular complex with plasminogen and histidine-rich glycoprotein. (Silverstein RL, Leung LL, Harpel PC, Nachman RL) J Clin Invest 1985 Jun;75(6):2065-73 PMID: 4008652 PMCID: PMC425568 SCOPUS ID: 2-s2.0-0022416271 06/01/1985 81 Citations

Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator. (Silverstein RL, Leung LL, Harpel PC, Nachman RL) J Clin Invest 1984 Nov;74(5):1625-33 PMID: 6438154 PMCID: PMC425339 SCOPUS ID: 2-s2.0-0021721455 11/01/1984 110 Citations

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Profiles for MCW, MU, MSOE, UWM, BCW, CW, Froedtert, and VA Faculty

Roy L. Silverstein MD

Chair, Center Associate Director, Professor

Publications (211)