Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Roy L. Silverstein MD

Roy L. Silverstein MD

Chairman, Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Administration
Program: Chairman

Member of the Cancer Center
Member of the Cardiovascular Center


Publications

  • Acrolein impairs the cholesterol transport functions of high density lipoproteins. (Chadwick AC, Holme RL, Chen Y, Thomas MJ, Sorci-Thomas MG, Silverstein RL, Pritchard KA Jr, Sahoo D) PLoS One 2015;10(4):e0123138 PMID: 25849485 PMCID: PMC4388475
  • Thrombospondin-1 restrains neutrophil granule serine protease function and regulates the innate immune response during Klebsiella pneumoniae infection. (Zhao Y, Olonisakin TF, Xiong Z, Hulver M, Sayeed S, Yu MT, Gregory AD, Kochman EJ, Chen BB, Mallampalli RK, Sun M, Silverstein RL, Stolz DB, Shapiro SD, Ray A, Ray P, Lee JS) Mucosal Immunol 2015 Jul;8(4):896-905 PMID: 25492474 PMCID: PMC4465063
  • Thymidine phosphorylase participates in platelet signaling and promotes thrombosis. (Li W, Gigante A, Perez-Perez MJ, Yue H, Hirano M, McIntyre TM, Silverstein RL) Circ Res 2014 Dec 5;115(12):997-1006 PMID: 25287063 PMCID: PMC4258140
  • Hyper-inflammation and skin destruction mediated by rosiglitazone activation of macrophages in IL-6 deficiency. (Das LM, Rosenjack J, Au L, Galle PS, Hansen MB, Cathcart MK, McCormick TS, Cooper KD, Silverstein RL, Lu KQ) J Invest Dermatol 2015 Feb;135(2):389-99 PMID: 25184961 PMCID: PMC4291681
  • Exosome poly-ubiquitin inhibits platelet activation, downregulates CD36 and inhibits pro-atherothombotic cellular functions. (Srikanthan S, Li W, Silverstein RL, McIntyre TM) J Thromb Haemost 2014 Nov;12(11):1906-17 PMID: 25163645 PMCID: PMC4229405
  • Platelet CD36 links not only α-granule-derived proteins to thrombus stability but also metabolic and oxidant stress to a prothrombotic phenotype. (Silverstein RL) Arterioscler Thromb Vasc Biol 2014 Jun;34(6):1120-1 PMID: 24828516
  • Cancer stem cell-specific scavenger receptor 36 drives glioblastoma progression. (Hale JS, Otvos B, Sinyuk M, Alvarado AG, Hitomi M, Stoltz K, Wu Q, Flavahan W, Levison B, Johansen ML, Schmitt D, Neltner JM, Huang P, Ren B, Sloan AE, Silverstein RL, Gladson CL, DiDonato JA, Brown JM, McIntyre T, Hazen SL, Horbinski C, Rich JN, Lathia JD) Stem Cells 2014 Jul;32(7):1746-58 PMID: 24737733 PMCID: PMC4063873
  • Platelet-derived S100 family member myeloid-related protein-14 regulates thrombosis. (Wang Y, Fang C, Gao H, Bilodeau ML, Zhang Z, Croce K, Liu S, Morooka T, Sakuma M, Nakajima K, Yoneda S, Shi C, Zidar D, Andre P, Stephens G, Silverstein RL, Hogg N, Schmaier AH, Simon DI) J Clin Invest 2014 May;124(5):2160-71 PMID: 24691441 PMCID: PMC4001535
  • Proteasome proteolysis supports stimulated platelet function and thrombosis. (Gupta N, Li W, Willard B, Silverstein RL, McIntyre TM) Arterioscler Thromb Vasc Biol 2014 Jan;34(1):160-8 PMID: 24177323 PMCID: PMC4059534
  • Lipopolysaccharide stimulates platelets through an IL-1β autocrine loop. (Brown GT, Narayanan P, Li W, Silverstein RL, McIntyre TM) J Immunol 2013 Nov 15;191(10):5196-203 PMID: 24081990 PMCID: PMC3818355
  • Thrombospondin-1 triggers macrophage IL-10 production and promotes resolution of experimental lung injury. (Zhao Y, Xiong Z, Lechner EJ, Klenotic PA, Hamburg BJ, Hulver M, Khare A, Oriss T, Mangalmurti N, Chan Y, Zhang Y, Ross MA, Stolz DB, Rosengart MR, Pilewski J, Ray P, Ray A, Silverstein RL, Lee JS) Mucosal Immunol 2014 Mar;7(2):440-8 PMID: 24045574 PMCID: PMC3945733
  • Thrombospondin-1 modulates VEGF signaling via CD36 by recruiting SHP-1 to VEGFR2 complex in microvascular endothelial cells. (Chu LY, Ramakrishnan DP, Silverstein RL) Blood 2013 Sep 5;122(10):1822-32 PMID: 23896411 PMCID: PMC3765061
  • Vav Guanine nucleotide exchange factors regulate atherosclerotic lesion development in mice. (Rahaman SO, Li W, Silverstein RL) Arterioscler Thromb Vasc Biol 2013 Sep;33(9):2053-7 PMID: 23825362 PMCID: PMC3864095
  • Nicotine potentiates proatherogenic effects of oxLDL by stimulating and upregulating macrophage CD36 signaling. (Zhou MS, Chadipiralla K, Mendez AJ, Jaimes EA, Silverstein RL, Webster K, Raij L) Am J Physiol Heart Circ Physiol 2013 Aug 15;305(4):H563-74 PMID: 23748423 PMCID: PMC3891251
  • Molecular basis of antiangiogenic thrombospondin-1 type 1 repeat domain interactions with CD36. (Klenotic PA, Page RC, Li W, Amick J, Misra S, Silverstein RL) Arterioscler Thromb Vasc Biol 2013 Jul;33(7):1655-62 PMID: 23640500 PMCID: PMC3737738
  • Loci influencing blood pressure identified using a cardiovascular gene-centric array. (Ganesh SK, Tragante V, Guo W, Guo Y, Lanktree MB, Smith EN, Johnson T, Castillo BA, Barnard J, Baumert J, Chang YP, Elbers CC, Farrall M, Fischer ME, Franceschini N, Gaunt TR, Gho JM, Gieger C, Gong Y, Isaacs A, Kleber ME, Mateo Leach I, McDonough CW, Meijs MF, Mellander O, Molony CM, Nolte IM, Padmanabhan S, Price TS, Rajagopalan R, Shaffer J, Shah S, Shen H, Soranzo N, van der Most PJ, Van Iperen EP, Van Setten J, Vonk JM, Zhang L, Beitelshees AL, Berenson GS, Bhatt DL, Boer JM, Boerwinkle E, Burkley B, Burt A, Chakravarti A, Chen W, Cooper-Dehoff RM, Curtis SP, Dreisbach A, Duggan D, Ehret GB, Fabsitz RR, Fornage M, Fox E, Furlong CE, Gansevoort RT, Hofker MH, Hovingh GK, Kirkland SA, Kottke-Marchant K, Kutlar A, Lacroix AZ, Langaee TY, Li YR, Lin H, Liu K, Maiwald S, Malik R, CARDIOGRAM, METASTROKE, Murugesan G, Newton-Cheh C, O'Connell JR, Onland-Moret NC, Ouwehand WH, Palmas W, Penninx BW, Pepine CJ, Pettinger M, Polak JF, Ramachandran VS, Ranchalis J, Redline S, Ridker PM, Rose LM, Scharnag H, Schork NJ, Shimbo D, Shuldiner AR, Srinivasan SR, Stolk RP, Taylor HA, Thorand B, Trip MD, van Duijn CM, Verschuren WM, Wijmenga C, Winkelmann BR, Wyatt S, Young JH, Boehm BO, Caulfield MJ, Chasman DI, Davidson KW, Doevendans PA, Fitzgerald GA, Gums JG, Hakonarson H, Hillege HL, Illig T, Jarvik GP, Johnson JA, Kastelein JJ, Koenig W, LifeLines Cohort Study, März W, Mitchell BD, Murray SS, Oldehinkel AJ, Rader DJ, Reilly MP, Reiner AP, Schadt EE, Silverstein RL, Snieder H, Stanton AV, Uitterlinden AG, van der Harst P, van der Schouw YT, Samani NJ, Johnson AD, Munroe PB, de Bakker PI, Zhu X, Levy D, Keating BJ, Asselbergs FW) Hum Mol Genet 2013 Apr 15;22(8):1663-78 PMID: 23303523 PMCID: PMC3657476
  • Ferric chloride-induced murine carotid arterial injury: A model of redox pathology. (Li W, McIntyre TM, Silverstein RL) Redox Biol 2013;1:50-5 PMID: 25101237 PMCID: PMC4116643
  • CD36 and Na/K-ATPase-α1 form a proinflammatory signaling loop in kidney. (Kennedy DJ, Chen Y, Huang W, Viterna J, Liu J, Westfall K, Tian J, Bartlett DJ, Tang WH, Xie Z, Shapiro JI, Silverstein RL) Hypertension 2013 Jan;61(1):216-24 PMID: 23172921 PMCID: PMC3521864
  • Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. (Asselbergs FW, Guo Y, van Iperen EP, Sivapalaratnam S, Tragante V, Lanktree MB, Lange LA, Almoguera B, Appelman YE, Barnard J, Baumert J, Beitelshees AL, Bhangale TR, Chen YD, Gaunt TR, Gong Y, Hopewell JC, Johnson T, Kleber ME, Langaee TY, Li M, Li YR, Liu K, McDonough CW, Meijs MF, Middelberg RP, Musunuru K, Nelson CP, O'Connell JR, Padmanabhan S, Pankow JS, Pankratz N, Rafelt S, Rajagopalan R, Romaine SP, Schork NJ, Shaffer J, Shen H, Smith EN, Tischfield SE, van der Most PJ, van Vliet-Ostaptchouk JV, Verweij N, Volcik KA, Zhang L, Bailey KR, Bailey KM, Bauer F, Boer JM, Braund PS, Burt A, Burton PR, Buxbaum SG, Chen W, Cooper-Dehoff RM, Cupples LA, deJong JS, Delles C, Duggan D, Fornage M, Furlong CE, Glazer N, Gums JG, Hastie C, Holmes MV, Illig T, Kirkland SA, Kivimaki M, Klein R, Klein BE, Kooperberg C, Kottke-Marchant K, Kumari M, LaCroix AZ, Mallela L, Murugesan G, Ordovas J, Ouwehand WH, Post WS, Saxena R, Scharnagl H, Schreiner PJ, Shah T, Shields DC, Shimbo D, Srinivasan SR, Stolk RP, Swerdlow DI, Taylor HA Jr, Topol EJ, Toskala E, van Pelt JL, van Setten J, Yusuf S, Whittaker JC, Zwinderman AH, LifeLines Cohort Study, Anand SS, Balmforth AJ, Berenson GS, Bezzina CR, Boehm BO, Boerwinkle E, Casas JP, Caulfield MJ, Clarke R, Connell JM, Cruickshanks KJ, Davidson KW, Day IN, de Bakker PI, Doevendans PA, Dominiczak AF, Hall AS, Hartman CA, Hengstenberg C, Hillege HL, Hofker MH, Humphries SE, Jarvik GP, Johnson JA, Kaess BM, Kathiresan S, Koenig W, Lawlor DA, März W, Melander O, Mitchell BD, Montgomery GW, Munroe PB, Murray SS, Newhouse SJ, Onland-Moret NC, Poulter N, Psaty B, Redline S, Rich SS, Rotter JI, Schunkert H, Sever P, Shuldiner AR, Silverstein RL, Stanton A, Thorand B, Trip MD, Tsai MY, van der Harst P, van der Schoot E, van der Schouw YT, Verschuren WM, Watkins H, Wilde AA, Wolffenbuttel BH, Whitfield JB, Hovingh GK, Ballantyne CM, Wijmenga C, Reilly MP, Martin NG, Wilson JG, Rader DJ, Samani NJ, Reiner AP, Hegele RA, Kastelein JJ, Hingorani AD, Talmud PJ, Hakonarson H, Elbers CC, Keating BJ, Drenos F) Am J Hum Genet 2012 Nov 2;91(5):823-38 PMID: 23063622 PMCID: PMC3487124
  • Context dependent role of the CD36--thrombospondin--histidine-rich glycoprotein axis in tumor angiogenesis and growth. (Hale JS, Li M, Sinyuk M, Jahnen-Dechent W, Lathia JD, Silverstein RL) PLoS One 2012;7(7):e40033 PMID: 22808089 PMCID: PMC3393734
  • Oxidized LDL/CD36 interaction induces loss of cell polarity and inhibits macrophage locomotion. (Park YM, Drazba JA, Vasanji A, Egelhoff T, Febbraio M, Silverstein RL) Mol Biol Cell 2012 Aug;23(16):3057-68 PMID: 22718904 PMCID: PMC3418302
  • P2RY1 and P2RY12 polymorphisms and on-aspirin platelet reactivity in patients with coronary artery disease. (Timur AA, Murugesan G, Zhang L, Aung PP, Barnard J, Wang QK, Gaussem P, Silverstein RL, Bhatt DL, Kottke-Marchant K) Int J Lab Hematol 2012 Oct;34(5):473-83 PMID: 22574824 PMCID: PMC3419334
  • Insulin promotes macrophage foam cell formation: potential implications in diabetes-related atherosclerosis. (Park YM, R Kashyap S, A Major J, Silverstein RL) Lab Invest 2012 Aug;92(8):1171-80 PMID: 22525426 PMCID: PMC3407326
  • Advanced glycation end products induce a prothrombotic phenotype in mice via interaction with platelet CD36. (Zhu W, Li W, Silverstein RL) Blood 2012 Jun 21;119(25):6136-44 PMID: 22431576 PMCID: PMC3383021
  • CD36 ectodomain phosphorylation blocks thrombospondin-1 binding: structure-function relationships and regulation by protein kinase C. (Chu LY, Silverstein RL) Arterioscler Thromb Vasc Biol 2012 Mar;32(3):760-7 PMID: 22247259 PMCID: PMC3298081
  • Teaching an old dog new tricks: potential antiatherothrombotic use for statins. (Silverstein RL) J Clin Invest 2012 Feb;122(2):478-81 PMID: 22214843 PMCID: PMC3266801
  • CD9 tetraspanin interacts with CD36 on the surface of macrophages: a possible regulatory influence on uptake of oxidized low density lipoprotein. (Huang W, Febbraio M, Silverstein RL) PLoS One 2011;6(12):e29092 PMID: 22216174 PMCID: PMC3244426
  • Vav protein guanine nucleotide exchange factor regulates CD36 protein-mediated macrophage foam cell formation via calcium and dynamin-dependent processes. (Rahaman SO, Zhou G, Silverstein RL) J Biol Chem 2011 Oct 14;286(41):36011-9 PMID: 21865158 PMCID: PMC3195569
  • Expression, purification and structural characterization of functionally replete thrombospondin-1 type 1 repeats in a bacterial expression system. (Klenotic PA, Page RC, Misra S, Silverstein RL) Protein Expr Purif 2011 Dec;80(2):253-9 PMID: 21821127 PMCID: PMC3195888
  • Loss of expression of neutrophil proteinase-3: a factor contributing to thrombotic risk in paroxysmal nocturnal hemoglobinuria. (Jankowska AM, Szpurka H, Calabro M, Mohan S, Schade AE, Clemente M, Silverstein RL, Maciejewski JP) Haematologica 2011 Jul;96(7):954-62 PMID: 21546506 PMCID: PMC3128213
  • Platelet CD36 surface expression levels affect functional responses to oxidized LDL and are associated with inheritance of specific genetic polymorphisms. (Ghosh A, Murugesan G, Chen K, Zhang L, Wang Q, Febbraio M, Anselmo RM, Marchant K, Barnard J, Silverstein RL) Blood 2011 Jun 9;117(23):6355-66 PMID: 21478428 PMCID: PMC3122954
  • Lysophosphatidic acid suppresses endothelial cell CD36 expression and promotes angiogenesis via a PKD-1-dependent signaling pathway. (Ren B, Hale J, Srikanthan S, Silverstein RL) Blood 2011 Jun 2;117(22):6036-45 PMID: 21441463 PMCID: PMC3112047
  • Vav guanine nucleotide exchange factors link hyperlipidemia and a prothrombotic state. (Chen K, Li W, Major J, Rahaman SO, Febbraio M, Silverstein RL) Blood 2011 May 26;117(21):5744-50 PMID: 21427288 PMCID: PMC3110031
  • Vav family Rho guanine nucleotide exchange factors regulate CD36-mediated macrophage foam cell formation. (Rahaman SO, Swat W, Febbraio M, Silverstein RL) J Biol Chem 2011 Mar 4;286(9):7010-7 PMID: 21209086 PMCID: PMC3044957
  • Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. (Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H, Rajagopalan R, Johnson T, Shen H, Nelson CP, Klopp N, Baumert J, Padmanabhan S, Pankratz N, Pankow JS, Shah S, Taylor K, Barnard J, Peters BJ, Maloney CM, Lobmeyer MT, Stanton A, Zafarmand MH, Romaine SP, Mehta A, van Iperen EP, Gong Y, Price TS, Smith EN, Kim CE, Li YR, Asselbergs FW, Atwood LD, Bailey KM, Bhatt D, Bauer F, Behr ER, Bhangale T, Boer JM, Boehm BO, Bradfield JP, Brown M, Braund PS, Burton PR, Carty C, Chandrupatla HR, Chen W, Connell J, Dalgeorgou C, Boer Ad, Drenos F, Elbers CC, Fang JC, Fox CS, Frackelton EC, Fuchs B, Furlong CE, Gibson Q, Gieger C, Goel A, Grobbee DE, Hastie C, Howard PJ, Huang GH, Johnson WC, Li Q, Kleber ME, Klein BE, Klein R, Kooperberg C, Ky B, Lacroix A, Lanken P, Lathrop M, Li M, Marshall V, Melander O, Mentch FD, Meyer NJ, Monda KL, Montpetit A, Murugesan G, Nakayama K, Nondahl D, Onipinla A, Rafelt S, Newhouse SJ, Otieno FG, Patel SR, Putt ME, Rodriguez S, Safa RN, Sawyer DB, Schreiner PJ, Simpson C, Sivapalaratnam S, Srinivasan SR, Suver C, Swergold G, Sweitzer NK, Thomas KA, Thorand B, Timpson NJ, Tischfield S, Tobin M, Tomaszewski M, Verschuren WM, Wallace C, Winkelmann B, Zhang H, Zheng D, Zhang L, Zmuda JM, Clarke R, Balmforth AJ, Danesh J, Day IN, Schork NJ, de Bakker PI, Delles C, Duggan D, Hingorani AD, Hirschhorn JN, Hofker MH, Humphries SE, Kivimaki M, Lawlor DA, Kottke-Marchant K, Mega JL, Mitchell BD, Morrow DA, Palmen J, Redline S, Shields DC, Shuldiner AR, Sleiman PM, Smith GD, Farrall M, Jamshidi Y, Christiani DC, Casas JP, Hall AS, Doevendans PA, Christie JD, Berenson GS, Murray SS, Illig T, Dorn GW 2nd, Cappola TP, Boerwinkle E, Sever P, Rader DJ, Reilly MP, Caulfield M, Talmud PJ, Topol E, Engert JC, Wang K, Dominiczak A, Hamsten A, Curtis SP, Silverstein RL, Lange LA, Sabatine MS, Trip M, Saleheen D, Peden JF, Cruickshanks KJ, März W, O'Connell JR, Klungel OH, Wijmenga C, Maitland-van der Zee AH, Schadt EE, Johnson JA, Jarvik GP, Papanicolaou GJ, Hugh Watkins on behalf of PROCARDIS, Grant SF, Munroe PB, North KE, Samani NJ, Koenig W, Gaunt TR, Anand SS, van der Schouw YT, Meena Kumari on behalf of the Whitehall II Study and the WHII 50K Group, Soranzo N, Fitzgerald GA, Reiner A, Hegele RA, Hakonarson H, Keating BJ) Am J Hum Genet 2011 Jan 7;88(1):6-18 PMID: 21194676 PMCID: PMC3014369
  • A CD36-dependent pathway enhances macrophage and adipose tissue inflammation and impairs insulin signalling. (Kennedy DJ, Kuchibhotla S, Westfall KM, Silverstein RL, Morton RE, Febbraio M) Cardiovasc Res 2011 Feb 15;89(3):604-13 PMID: 21088116 PMCID: PMC3028977
  • CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. (Li W, Febbraio M, Reddy SP, Yu DY, Yamamoto M, Silverstein RL) J Clin Invest 2010 Nov;120(11):3996-4006 PMID: 20978343 PMCID: PMC2964976
  • A novel broadband impedance method for detection of cell-derived microparticles. (Lvovich V, Srikanthan S, Silverstein RL) Biosens Bioelectron 2010 Oct 15;26(2):444-51 PMID: 20729061 PMCID: PMC2946439
  • Mechanisms of cell signaling by the scavenger receptor CD36: implications in atherosclerosis and thrombosis. (Silverstein RL, Li W, Park YM, Rahaman SO) Trans Am Clin Climatol Assoc 2010;121:206-20 PMID: 20697562 PMCID: PMC2917163
  • Histidine-rich glycoprotein modulates the anti-angiogenic effects of vasculostatin. (Klenotic PA, Huang P, Palomo J, Kaur B, Van Meir EG, Vogelbaum MA, Febbraio M, Gladson CL, Silverstein RL) Am J Pathol 2010 Apr;176(4):2039-50 PMID: 20167858 PMCID: PMC2843491
  • Type 2 scavenger receptor CD36 in platelet activation: the role of hyperlipemia and oxidative stress. (Silverstein RL) Clin Lipidol 2009 Dec;4(6):767 PMID: 20161667 PMCID: PMC2819200
  • Lipid-induced insulin resistance is associated with increased monocyte expression of scavenger receptor CD36 and internalization of oxidized LDL. (Kashyap SR, Ioachimescu AG, Gornik HL, Gopan T, Davidson MB, Makdissi A, Major J, Febbraio M, Silverstein RL) Obesity (Silver Spring) 2009 Dec;17(12):2142-8 PMID: 19521352 PMCID: PMC2836489
  • CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior. (Silverstein RL, Febbraio M) Sci Signal 2009;2(72):re3 PMID: 19471024 PMCID: PMC2811062
  • Inflammation, atherosclerosis, and arterial thrombosis: role of the scavenger receptor CD36. (Silverstein RL) Cleve Clin J Med 2009 Apr;76 Suppl 2:S27-30 PMID: 19376978 PMCID: PMC2810530
  • TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis. (Drage MG, Pecora ND, Hise AG, Febbraio M, Silverstein RL, Golenbock DT, Boom WH, Harding CV) Cell Immunol 2009;258(1):29-37 PMID: 19362712 PMCID: PMC2730726
  • Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism. (Kaur B, Cork SM, Sandberg EM, Devi NS, Zhang Z, Klenotic PA, Febbraio M, Shim H, Mao H, Tucker-Burden C, Silverstein RL, Brat DJ, Olson JJ, Van Meir EG) Cancer Res 2009 Feb 1;69(3):1212-20 PMID: 19176395 PMCID: PMC2659670
  • CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima. (Park YM, Febbraio M, Silverstein RL) J Clin Invest 2009 Jan;119(1):136-45 PMID: 19065049 PMCID: PMC2613464
  • Biological surgery: synergetic angiogenic therapy using coadministration of two progenitor cell populations. (Li W, Silverstein RL) Circ Res 2008 Sep 26;103(7):684-6 PMID: 18818411 PMCID: PMC2777677
  • Thrombospondin-1-induced apoptosis of brain microvascular endothelial cells can be mediated by TNF-R1. (Rege TA, Stewart J Jr, Dranka B, Benveniste EN, Silverstein RL, Gladson CL) J Cell Physiol 2009 Jan;218(1):94-103 PMID: 18726995 PMCID: PMC2597846
  • Deficiency of LRP8 in mice is associated with altered platelet function and prolonged time for in vivo thrombosis. (Robertson JO, Li W, Silverstein RL, Topol EJ, Smith JD) Thromb Res 2009 Feb;123(4):644-52 PMID: 18706682 PMCID: PMC2661626
  • A specific CD36-dependent signaling pathway is required for platelet activation by oxidized low-density lipoprotein. (Chen K, Febbraio M, Li W, Silverstein RL) Circ Res 2008 Jun 20;102(12):1512-9 PMID: 18497330 PMCID: PMC2749986
  • Platelet CD36 mediates interactions with endothelial cell-derived microparticles and contributes to thrombosis in mice. (Ghosh A, Li W, Febbraio M, Espinola RG, McCrae KR, Cockrell E, Silverstein RL) J Clin Invest 2008 May;118(5):1934-43 PMID: 18431509 PMCID: PMC2323190
  • Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis. (Zhou J, Febbraio M, Wada T, Zhai Y, Kuruba R, He J, Lee JH, Khadem S, Ren S, Li S, Silverstein RL, Xie W) Gastroenterology 2008 Feb;134(2):556-67 PMID: 18242221
  • CD36-TSP-HRGP interactions in the regulation of angiogenesis. (Silverstein RL, Febbraio M) Curr Pharm Des 2007;13(35):3559-67 PMID: 18220792
  • Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype. (Podrez EA, Byzova TV, Febbraio M, Salomon RG, Ma Y, Valiyaveettil M, Poliakov E, Sun M, Finton PJ, Curtis BR, Chen J, Zhang R, Silverstein RL, Hazen SL) Nat Med 2007 Sep;13(9):1086-95 PMID: 17721545 PMCID: PMC3042888
  • Venous thrombosis in the elderly: more questions than answers. (Silverstein RL, Bauer KA, Cushman M, Esmon CT, Ershler WB, Tracy RP) Blood 2007 Nov 1;110(9):3097-101 PMID: 17684155
  • CD36: implications in cardiovascular disease. (Febbraio M, Silverstein RL) Int J Biochem Cell Biol 2007;39(11):2012-30 PMID: 17466567 PMCID: PMC2034445
  • A CD36-dependent signaling cascade is necessary for macrophage foam cell formation. (Rahaman SO, Lennon DJ, Febbraio M, Podrez EA, Hazen SL, Silverstein RL) Cell Metab 2006 Sep;4(3):211-21 PMID: 16950138 PMCID: PMC1855263
  • Neprilysin inhibits angiogenesis via proteolysis of fibroblast growth factor-2. (Goodman OB Jr, Febbraio M, Simantov R, Zheng R, Shen R, Silverstein RL, Nanus DM) J Biol Chem 2006 Nov 3;281(44):33597-605 PMID: 16940054
  • Light-induced oxidation of photoreceptor outer segment phospholipids generates ligands for CD36-mediated phagocytosis by retinal pigment epithelium: a potential mechanism for modulating outer segment phagocytosis under oxidant stress conditions. (Sun M, Finnemann SC, Febbraio M, Shan L, Annangudi SP, Podrez EA, Hoppe G, Darrow R, Organisciak DT, Salomon RG, Silverstein RL, Hazen SL) J Biol Chem 2006 Feb 17;281(7):4222-30 PMID: 16354659 PMCID: PMC3627732
  • EP 80317, a ligand of the CD36 scavenger receptor, protects apolipoprotein E-deficient mice from developing atherosclerotic lesions. (Marleau S, Harb D, Bujold K, Avallone R, Iken K, Wang Y, Demers A, Sirois MG, Febbraio M, Silverstein RL, Tremblay A, Ong H) FASEB J 2005 Nov;19(13):1869-71 PMID: 16123174
  • A novel isoform of human Golgi complex-localized glycoprotein-1 (also known as E-selectin ligand-1, MG-160 and cysteine-rich fibroblast growth factor receptor) targets differential subcellular localization. (Ahn J, Febbraio M, Silverstein RL) J Cell Sci 2005 Apr 15;118(Pt 8):1725-31 PMID: 15797922
  • The class B scavenger receptor CD36 mediates free radical production and tissue injury in cerebral ischemia. (Cho S, Park EM, Febbraio M, Anrather J, Park L, Racchumi G, Silverstein RL, Iadecola C) J Neurosci 2005 Mar 9;25(10):2504-12 PMID: 15758158
  • The antiangiogenic effect of thrombospondin-2 is mediated by CD36 and modulated by histidine-rich glycoprotein. (Simantov R, Febbraio M, Silverstein RL) Matrix Biol 2005 Feb;24(1):27-34 PMID: 15748999
  • Stem cell transplantation reveals that absence of macrophage CD36 is protective against atherosclerosis. (Febbraio M, Guy E, Silverstein RL) Arterioscler Thromb Vasc Biol 2004 Dec;24(12):2333-8 PMID: 15486305
  • The second international congress on myeloproliferative and myelodysplastic syndromes. (Silver RT, Bennett JM, Deininger M, Feldman E, Rafii S, Silverstein RL, Solberg LA, Spivak JL) Leuk Res 2004 Sep;28(9):979-85 PMID: 15234576
  • CD36 mediates the phagocytosis of Plasmodium falciparum-infected erythrocytes by rodent macrophages. (Patel SN, Serghides L, Smith TG, Febbraio M, Silverstein RL, Kurtz TW, Pravenec M, Kain KC) J Infect Dis 2004 Jan 15;189(2):204-13 PMID: 14722884
  • Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo. (Ling Q, Jacovina AT, Deora A, Febbraio M, Simantov R, Silverstein RL, Hempstead B, Mark WH, Hajjar KA) J Clin Invest 2004 Jan;113(1):38-48 PMID: 14702107 PMCID: PMC300771
  • CD36: a critical anti-angiogenic receptor. (Simantov R, Silverstein RL) Front Biosci 2003 Sep 1;8:s874-82 PMID: 12957861
  • Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/ KDR. (Bais C, Van Geelen A, Eroles P, Mutlu A, Chiozzini C, Dias S, Silverstein RL, Rafii S, Mesri EA) Cancer Cell 2003 Feb;3(2):131-43 PMID: 12620408
  • CD36-mediated nonopsonic phagocytosis of erythrocytes infected with stage I and IIA gametocytes of Plasmodium falciparum. (Smith TG, Serghides L, Patel SN, Febbraio M, Silverstein RL, Kain KC) Infect Immun 2003 Jan;71(1):393-400 PMID: 12496189 PMCID: PMC143147
  • The impact of overexpression and deficiency of fatty acid translocase (FAT)/CD36. (Febbraio M, Guy E, Coburn C, Knapp FF Jr, Beets AL, Abumrad NA, Silverstein RL) Mol Cell Biochem 2002 Oct;239(1-2):193-7 PMID: 12479585
  • The face of TSR revealed: an extracellular signaling domain is exposed. (Silverstein RL) J Cell Biol 2002 Oct 28;159(2):203-6 PMID: 12403807 PMCID: PMC2173053
  • A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions. (Podrez EA, Poliakov E, Shen Z, Zhang R, Deng Y, Sun M, Finton PJ, Shan L, Febbraio M, Hajjar DP, Silverstein RL, Hoff HF, Salomon RG, Hazen SL) J Biol Chem 2002 Oct 11;277(41):38517-23 PMID: 12145296
  • CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart. (Bodart V, Febbraio M, Demers A, McNicoll N, Pohankova P, Perreault A, Sejlitz T, Escher E, Silverstein RL, Lamontagne D, Ong H) Circ Res 2002 May 3;90(8):844-9 PMID: 11988484
  • Hematology grants workshop-2001. (Todd RF 3rd, Miller DM, Silverstein RL) Hematology Am Soc Hematol Educ Program 2001:507-21 PMID: 11723002
  • Hematology Grants Workshop-2000. (Todd RF 3rd, Miller DM, Silverstein RL) Hematology Am Soc Hematol Educ Program 2000;():424-437 PMID: 11701555
  • Differential roles of CD36 and alphavbeta5 integrin in photoreceptor phagocytosis by the retinal pigment epithelium. (Finnemann SC, Silverstein RL) J Exp Med 2001 Nov 5;194(9):1289-98 PMID: 11696594 PMCID: PMC2195987
  • CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism. (Febbraio M, Hajjar DP, Silverstein RL) J Clin Invest 2001 Sep;108(6):785-91 PMID: 11560944 PMCID: PMC200943
  • Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1. (Simantov R, Febbraio M, Crombie R, Asch AS, Nachman RL, Silverstein RL) J Clin Invest 2001 Jan;107(1):45-52 PMID: 11134179 PMCID: PMC198540
  • CD36 and atherosclerosis. (Silverstein RL, Febbraio M) Curr Opin Lipidol 2000 Oct;11(5):483-91 PMID: 11048891
  • Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice. (Coburn CT, Knapp FF Jr, Febbraio M, Beets AL, Silverstein RL, Abumrad NA) J Biol Chem 2000 Oct 20;275(42):32523-9 PMID: 10913136
  • CD36 in atherosclerosis. The role of a class B macrophage scavenger receptor. (Nicholson AC, Febbraio M, Han J, Silverstein RL, Hajjar DP) Ann N Y Acad Sci 2000 May;902:128-31; discussion 131-3 PMID: 10865832
  • Induction of CD36 expression by oxidized LDL and IL-4 by a common signaling pathway dependent on protein kinase C and PPAR-gamma. (Feng J, Han J, Pearce SF, Silverstein RL, Gotto AM Jr, Hajjar DP, Nicholson AC) J Lipid Res 2000 May;41(5):688-96 PMID: 10787429
  • Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species. (Podrez EA, Febbraio M, Sheibani N, Schmitt D, Silverstein RL, Hajjar DP, Cohen PA, Frazier WA, Hoff HF, Hazen SL) J Clin Invest 2000 Apr;105(8):1095-108 PMID: 10772654 PMCID: PMC300829
  • Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice. (Febbraio M, Podrez EA, Smith JD, Hajjar DP, Hazen SL, Hoff HF, Sharma K, Silverstein RL) J Clin Invest 2000 Apr;105(8):1049-56 PMID: 10772649 PMCID: PMC300837
  • Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1. (Jiménez B, Volpert OV, Crawford SE, Febbraio M, Silverstein RL, Bouck N) Nat Med 2000 Jan;6(1):41-8 PMID: 10613822
  • Stromal derived factor-1-induced chemokinesis of cord blood CD34(+) cells (long-term culture-initiating cells) through endothelial cells is mediated by E-selectin. (Naiyer AJ, Jo DY, Ahn J, Mohle R, Peichev M, Lam G, Silverstein RL, Moore MA, Rafii S) Blood 1999 Dec 15;94(12):4011-9 PMID: 10590044
  • Angiogenesis and atherosclerosis. The mandate broadens. (Silverstein RL, Nachman RL) Circulation 1999 Aug 24;100(8):783-5 PMID: 10458710
  • A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism. (Febbraio M, Abumrad NA, Hajjar DP, Sharma K, Cheng W, Pearce SF, Silverstein RL) J Biol Chem 1999 Jul 2;274(27):19055-62 PMID: 10383407
  • Retinoic acid alters the mechanism of attachment of malignant astrocytoma and neuroblastoma cells to thrombospondin-1. (Pijuan-Thompson V, Grammer JR, Stewart J, Silverstein RL, Pearce SF, Tuszynski GP, Murphy-Ullrich JE, Gladson CL) Exp Cell Res 1999 May 25;249(1):86-101 PMID: 10328956
  • Three distinct D-amino acid substitutions confer potent antiangiogenic activity on an inactive peptide derived from a thrombospondin-1 type 1 repeat. (Dawson DW, Volpert OV, Pearce SF, Schneider AJ, Silverstein RL, Henkin J, Bouck NP) Mol Pharmacol 1999 Feb;55(2):332-8 PMID: 9927626
  • Recombinant glutathione S-transferase/CD36 fusion proteins define an oxidized low density lipoprotein-binding domain. (Pearce SF, Roy P, Nicholson AC, Hajjar DP, Febbraio M, Silverstein RL) J Biol Chem 1998 Dec 25;273(52):34875-81 PMID: 9857015
  • Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. (Albert ML, Pearce SF, Francisco LM, Sauter B, Roy P, Silverstein RL, Bhardwaj N) J Exp Med 1998 Oct 5;188(7):1359-68 PMID: 9763615 PMCID: PMC2212488
  • Cell adhesion molecules: an overview. (Joseph-Silverstein J, Silverstein RL) Cancer Invest 1998;16(3):176-82 PMID: 9541632
  • Identification of a CD36-related thrombospondin 1-binding domain in HIV-1 envelope glycoprotein gp120: relationship to HIV-1-specific inhibitory factors in human saliva. (Crombie R, Silverstein RL, MacLow C, Pearce SF, Nachman RL, Laurence J) J Exp Med 1998 Jan 5;187(1):25-35 PMID: 9419208 PMCID: PMC2199189
  • CD36 mediates the In vitro inhibitory effects of thrombospondin-1 on endothelial cells. (Dawson DW, Pearce SF, Zhong R, Silverstein RL, Frazier WA, Bouck NP) J Cell Biol 1997 Aug 11;138(3):707-17 PMID: 9245797 PMCID: PMC2141641
  • CD36 expression is altered in retinal pigment epithelial cells of the RCS rat. (Sparrow JR, Ryeom SW, Abumrad NA, Ibrahimi A, Silverstein RL) Exp Eye Res 1997 Jan;64(1):45-56 PMID: 9093020
  • Engagement of the Lewis X antigen (CD15) results in monocyte activation. (Lo SK, Golenbock DT, Sass PM, Maskati A, Xu H, Silverstein RL) Blood 1997 Jan 1;89(1):307-14 PMID: 8978306
  • Factor V Leiden increases the risk of thrombosis in patients with antiphospholipid antibodies. (Simantov R, Lo SK, Salmon JE, Sammaritano LR, Silverstein RL) Thromb Res 1996 Dec 1;84(5):361-5 PMID: 8948063
  • Antiphospholipid antibodies activate vascular endothelial cells. (Simantov R, Lo SK, Gharavi A, Sammaritano LR, Salmon JE, Silverstein RL) Lupus 1996 Oct;5(5):440-1 PMID: 8902777
  • Binding of anionic phospholipids to retinal pigment epithelium may be mediated by the scavenger receptor CD36. (Ryeom SW, Silverstein RL, Scotto A, Sparrow JR) J Biol Chem 1996 Aug 23;271(34):20536-9 PMID: 8702796
  • Regulation of monocyte CD36 and thrombospondin-1 expression by soluble mediators. (Yesner LM, Huh HY, Pearce SF, Silverstein RL) Arterioscler Thromb Vasc Biol 1996 Aug;16(8):1019-25 PMID: 8696941
  • Hypercoagulability in cancer. (Green KB, Silverstein RL) Hematol Oncol Clin North Am 1996 Apr;10(2):499-530 PMID: 8707766
  • Regulated expression of CD36 during monocyte-to-macrophage differentiation: potential role of CD36 in foam cell formation. (Huh HY, Pearce SF, Yesner LM, Schindler JL, Silverstein RL) Blood 1996 Mar 1;87(5):2020-8 PMID: 8634453
  • CD36 participates in the phagocytosis of rod outer segments by retinal pigment epithelium. (Ryeom SW, Sparrow JR, Silverstein RL) J Cell Sci 1996 Feb;109 ( Pt 2):387-95 PMID: 8838662
  • Activation of cultured vascular endothelial cells by antiphospholipid antibodies. (Simantov R, LaSala JM, Lo SK, Gharavi AE, Sammaritano LR, Salmon JE, Silverstein RL) J Clin Invest 1995 Nov;96(5):2211-9 PMID: 7593607 PMCID: PMC185871
  • Thrombosis and inflammation as multicellular processes: significance of cell-cell interactions. (Marcus AJ, Safier LB, Broekman MJ, Islam N, Fliessbach JH, Hajjar KA, Kaminski WE, Jendraschak E, Silverstein RL, von Schacky C) Thromb Haemost 1995 Jul;74(1):213-7 PMID: 8578460
  • CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis. (Ren Y, Silverstein RL, Allen J, Savill J) J Exp Med 1995 May 1;181(5):1857-62 PMID: 7536797 PMCID: PMC2192004
  • Induction of tissue factor on monocytes by adhesion to endothelial cells. (Lo SK, Cheung A, Zheng Q, Silverstein RL) J Immunol 1995 May 1;154(9):4768-77 PMID: 7536780
  • CD36 induction on human monocytes upon adhesion to tumor necrosis factor-activated endothelial cells. (Huh HY, Lo SK, Yesner LM, Silverstein RL) J Biol Chem 1995 Mar 17;270(11):6267-71 PMID: 7534309
  • Recombinant GST/CD36 fusion proteins define a thrombospondin binding domain. Evidence for a single calcium-dependent binding site on CD36. (Frieda S, Pearce A, Wu J, Silverstein RL) J Biol Chem 1995 Feb 17;270(7):2981-6 PMID: 7531696
  • Oxidized LDL binds to CD36 on human monocyte-derived macrophages and transfected cell lines. Evidence implicating the lipid moiety of the lipoprotein as the binding site. (Nicholson AC, Frieda S, Pearce A, Silverstein RL) Arterioscler Thromb Vasc Biol 1995 Feb;15(2):269-75 PMID: 7538425
  • Principles of thromboregulation: control of platelet reactivity in vascular disease. (Marcus AJ, Safier LB, Kaminski WE, Islam N, Hajjar KA, Jendraschak E, Silverstein RL, Broekman MJ, von Schacky C, Fliessbach JH) Adv Prostaglandin Thromboxane Leukot Res 1995;23:413-8 PMID: 7732885
  • A carboxyl terminal truncation mutant of CD36 is secreted and binds thrombospondin: evidence for a single transmembrane domain. (Pearce SF, Wu J, Silverstein RL) Blood 1994 Jul 15;84(2):384-9 PMID: 7517712
  • CD antigens 1993. (Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein RL, Springer TA) Immunol Today 1994 Mar;15(3):98-9 PMID: 7909665
  • CD antigens 1993. (Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein RL, Springer TA) Blood 1994 Feb 15;83(4):879-80 PMID: 8111060
  • CD antigens 1993. (Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein RL, Springer TA) J Immunol 1994 Jan 1;152(1):1-2 PMID: 7902854
  • von Willebrand factor mediates platelet adhesion to virally infected endothelial cells. (Etingin OR, Silverstein RL, Hajjar DP) Proc Natl Acad Sci U S A 1993 Jun 1;90(11):5153-6 PMID: 8389471 PMCID: PMC46673
  • Cancer and clotting--Trousseau's warning. (Silverstein RL, Nachman RL) N Engl J Med 1992 Oct 15;327(16):1163-4 PMID: 1308758
  • Identification of lysosome-associated membrane protein-2 as an activation-dependent platelet surface glycoprotein. (Silverstein RL, Febbraio M) Blood 1992 Sep 15;80(6):1470-5 PMID: 1520873
  • Sense and antisense cDNA transfection of CD36 (glycoprotein IV) in melanoma cells. Role of CD36 as a thrombospondin receptor. (Silverstein RL, Baird M, Lo SK, Yesner LM) J Biol Chem 1992 Aug 15;267(23):16607-12 PMID: 1379600
  • Identification of a monocyte receptor on herpesvirus-infected endothelial cells. (Etingin OR, Silverstein RL, Hajjar DP) Proc Natl Acad Sci U S A 1991 Aug 15;88(16):7200-3 PMID: 1714592 PMCID: PMC52261
  • CD36-mediated signal transduction in human monocytes by anti-CD36 antibodies but not by anti-thrombospondin antibodies recognizing cell membrane-bound thrombospondin. (Schüepp BJ, Pfister H, Clemetson KJ, Silverstein RL, Jungi TW) Biochem Biophys Res Commun 1991 Feb 28;175(1):263-70 PMID: 1998511
  • Identification and characterization of LAMP-1 as an activation-dependent platelet surface glycoprotein. (Febbraio M, Silverstein RL) J Biol Chem 1990 Oct 25;265(30):18531-7 PMID: 2211717
  • Thrombospondin forms complexes with single-chain and two-chain forms of urokinase. (Silverstein RL, Nachman RL, Pannell R, Gurewich V, Harpel PC) J Biol Chem 1990 Jul 5;265(19):11289-94 PMID: 2141608
  • Viral activation of the coagulation cascade: molecular interactions at the surface of infected endothelial cells. (Etingin OR, Silverstein RL, Friedman HM, Hajjar DP) Cell 1990 May 18;61(4):657-62 PMID: 2160855
  • Glycoprotein IV mediates thrombospondin-dependent platelet-monocyte and platelet-U937 cell adhesion. (Silverstein RL, Asch AS, Nachman RL) J Clin Invest 1989 Aug;84(2):546-52 PMID: 2474571 PMCID: PMC548914
  • Binding of Lys-plasminogen to monocytes/macrophages. (Silverstein RL, Friedlander RJ Jr, Nicholas RL, Nachman RL) J Clin Invest 1988 Dec;82(6):1948-55 PMID: 2974046 PMCID: PMC442776
  • Tumor necrosis factor-mediated release of platelet-derived growth factor from cultured endothelial cells. (Hajjar KA, Hajjar DP, Silverstein RL, Nachman RL) J Exp Med 1987 Jul 1;166(1):235-45 PMID: 3598461 PMCID: PMC2188629
  • Thrombospondin-plasminogen interactions: modulation of plasmin generation. (Silverstein RL, Nachman RL) Semin Thromb Hemost 1987 Jul;13(3):335-42 PMID: 2961063
  • Isolation of the thrombospondin membrane receptor. (Asch AS, Barnwell J, Silverstein RL, Nachman RL) J Clin Invest 1987 Apr;79(4):1054-61 PMID: 2435757 PMCID: PMC424283
  • Thrombospondin binds to monocytes-macrophages and mediates platelet-monocyte adhesion. (Silverstein RL, Nachman RL) J Clin Invest 1987 Mar;79(3):867-74 PMID: 3818952 PMCID: PMC424223
  • Binding of plasminogen to extracellular matrix. (Knudsen BS, Silverstein RL, Leung LL, Harpel PC, Nachman RL) J Biol Chem 1986 Aug 15;261(23):10765-71 PMID: 3090040
  • Tissue plasminogen activator and urokinase enhance the binding of plasminogen to thrombospondin. (Silverstein RL, Harpel PC, Nachman RL) J Biol Chem 1986 Jul 25;261(21):9959-65 PMID: 2942536
  • Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor. (Nachman RL, Hajjar KA, Silverstein RL, Dinarello CA) J Exp Med 1986 Jun 1;163(6):1595-600 PMID: 3086483 PMCID: PMC2188126
  • Thrombospondin: a versatile multifunctional glycoprotein. (Silverstein RL, Leung LL, Nachman RL) Arteriosclerosis 1986 May-Jun;6(3):245-53 PMID: 3518684
  • Activation of immobilized plasminogen by tissue activator. Multimolecular complex formation. (Silverstein RL, Nachman RL, Leung LL, Harpel PC) J Biol Chem 1985 Aug 25;260(18):10346-52 PMID: 3160707
  • Platelet thrombospondin forms a trimolecular complex with plasminogen and histidine-rich glycoprotein. (Silverstein RL, Leung LL, Harpel PC, Nachman RL) J Clin Invest 1985 Jun;75(6):2065-73 PMID: 4008652 PMCID: PMC425568
  • Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator. (Silverstein RL, Leung LL, Harpel PC, Nachman RL) J Clin Invest 1984 Nov;74(5):1625-33 PMID: 6438154 PMCID: PMC425339
  • Last update: 05/26/2015