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| 4 | Zinc-chelating BET bromodomain inhibitors equally target islet endocrine cell types. (Jones Lipinski RA, Stancill JS, Nuñez R, Wynia-Smith SL, Sprague DJ, Nord JA, Bird A, Corbett JA, Smith BC) Am J Physiol Regul Integr Comp Physiol 2024 Jun 01;326(6):R515-R527 |
| 2 | Cancer-associated polybromo-1 bromodomain 4 missense variants variably impact bromodomain ligand binding and cell growth suppression. (Bursch KL, Goetz CJ, Jiao G, Nuñez R, Olp MD, Dhiman A, Khurana M, Zimmermann MT, Urrutia RA, Dykhuizen EC, Smith BC) J Biol Chem 2024 Apr;300(4):107146 2 Citations |
| 1 | HLA Class I Genotype Is Associated with Relapse Risk after Allogeneic Stem Cell Transplantation for NPM1-Mutated Acute Myeloid Leukemia. (Narayan R, Niroula A, Wang T, Kuxhausen M, He M, Meyer E, Chen YB, Bhatt VR, Beitinjaneh A, Nishihori T, Sharma A, Brown VI, Kamoun M, Diaz MA, Abid MB, Askar M, Kanakry CG, Gragert L, Bolon YT, Marsh SGE, Gadalla SM, Paczesny S, Spellman S, Lee SJ) Transplant Cell Ther 2023 Jul;29(7):452.e1-452.e11 2 Citations |
| 1 | DNA Sequencing to Detect Residual Disease in Adults With Acute Myeloid Leukemia Prior to Hematopoietic Cell Transplant. (Dillon LW, Gui G, Page KM, Ravindra N, Wong ZC, Andrew G, Mukherjee D, Zeger SL, El Chaer F, Spellman S, Howard A, Chen K, Auletta J, Devine SM, Jimenez Jimenez AM, De Lima MJG, Litzow MR, Kebriaei P, Saber W, Weisdorf DJ, Hourigan CS) JAMA 2023 Mar 07;329(9):745-755 75 Citations |
| 3 | Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening. (Shishodia S, Nuñez R, Strohmier BP, Bursch KL, Goetz CJ, Olp MD, Jensen DR, Fenske TG, Ordonez-Rubiano SC, Blau ME, Roach MK, Peterson FC, Volkman BF, Dykhuizen EC, Smith BC) J Med Chem 2022 Oct 27;65(20):13714-13735 14 Citations |
| 4 | N-terminal BET bromodomain inhibitors disrupt a BRD4-p65 interaction and reduce inducible nitric oxide synthase transcription in pancreatic β-cells. (Nord JA, Wynia-Smith SL, Gehant AL, Jones Lipinski RA, Naatz A, Rioja I, Prinjha RK, Corbett JA, Smith BC) Front Endocrinol (Lausanne) 2022;13:923925 7 Citations |
| 2 | Combinatorial genetics reveals the Dock1-Rac2 axis as a potential target for the treatment of NPM1;Cohesin mutated AML. (Meyer AE, Stelloh C, Pulakanti K, Burns R, Fisher JB, Heimbruch KE, Tarima S, Furumo Q, Brennan J, Zheng Y, Viny AD, Vassiliou GS, Rao S) Leukemia 2022 Aug;36(8):2032-2041 6 Citations |
| 2 | A complex KMT2A::AFF3 fusion resulting from a three-way chromosomal rearrangement in pediatric B lymphoblastic leukemia. (Miller LJ, Leventaki V, Harker-Murray PD, Drendel HM, Bone KM) Cancer Genet 2022 Apr;262-263:43-46 |
| 1 | SMARCA4: Implications of an Altered Chromatin-Remodeling Gene for Cancer Development and Therapy. (Mardinian K, Adashek JJ, Botta GP, Kato S, Kurzrock R) Mol Cancer Ther 2021 Dec;20(12):2341-2351 87 Citations |
| 2 | WDR37 syndrome: identification of a distinct new cluster of disease-associated variants and functional analyses of mutant proteins. (Sorokina EA, Reis LM, Thompson S, Agre K, Babovic-Vuksanovic D, Ellingson MS, Hasadsri L, van Bever Y, Semina EV) Hum Genet 2021 Dec;140(12):1775-1789 7 Citations |
| 1 | SWI/SNF complex alterations as a biomarker of immunotherapy efficacy in pancreatic cancer. (Botta GP, Kato S, Patel H, Fanta P, Lee S, Okamura R, Kurzrock R) JCI Insight 2021 Sep 22;6(18) 43 Citations |
| 1 | Variants in GCNA, X-linked germ-cell genome integrity gene, identified in men with primary spermatogenic failure. (Hardy JJ, Wyrwoll MJ, Mcfadden W, Malcher A, Rotte N, Pollock NC, Munyoki S, Veroli MV, Houston BJ, Xavier MJ, Kasak L, Punab M, Laan M, Kliesch S, Schlegel P, Jaffe T, Hwang K, Vukina J, Brieño-Enríquez MA, Orwig K, Yanowitz J, Buszczak M, Veltman JA, Oud M, Nagirnaja L, Olszewska M, O'Bryan MK, Conrad DF, Kurpisz M, Tüttelmann F, Yatsenko AN, GEMINI Consortium) Hum Genet 2021 Aug;140(8):1169-1182 23 Citations |
| 1 | Wedding of Molecular Alterations and Immune Checkpoint Blockade: Genomics as a Matchmaker. (Fountzilas E, Kurzrock R, Vo HH, Tsimberidou AM) J Natl Cancer Inst 2021 Nov 29;113(12):1634-1647 29 Citations |
| 1 | Inhibiting β-catenin disables nucleolar functions in triple-negative breast cancer. (Weeks SE, Kammerud SC, Metge BJ, AlSheikh HA, Schneider DA, Chen D, Wei S, Mobley JA, Ojesina AI, Shevde LA, Samant RS) Cell Death Dis 2021 Mar 04;12(3):242 15 Citations |
| 1 | BAP1-Mutated Clear Cell Renal Cell Carcinoma. (Gallan AJ, Parilla M, Segal J, Ritterhouse L, Antic T) Am J Clin Pathol 2021 Apr 26;155(5):718-728 40 Citations |
| 3 | Endothelial Twist1-PDGFB signaling mediates hypoxia-induced proliferation and migration of αSMA-positive cells. (Mammoto A, Hendee K, Muyleart M, Mammoto T) Sci Rep 2020 May 05;10(1):7563 21 Citations |
| 1 | Myocardin and Kv1 Channels: A Paradigm Shift in Treating Vascular Smooth Muscle Cell-Related Proliferative Disease? (Zhang DX, Gutterman DD) Arterioscler Thromb Vasc Biol 2019 Dec;39(12):2454-2456 2 Citations |
| 1 | Integrated pan-cancer gene expression and drug sensitivity analysis reveals SLFN11 mRNA as a solid tumor biomarker predictive of sensitivity to DNA-damaging chemotherapy. (Shee K, Wells JD, Jiang A, Miller TW) PLoS One 2019;14(11):e0224267 34 Citations |
| 1 | De Novo Missense Variants in WDR37 Cause a Severe Multisystemic Syndrome. (Reis LM, Sorokina EA, Thompson S, Muheisen S, Velinov M, Zamora C, Aylsworth AS, Semina EV) Am J Hum Genet 2019 Aug 01;105(2):425-433 27 Citations |
| 1 | Genomic Alterations in Undifferentiated Malignant Tumors with Rhabdoid Phenotype and Loss of BRG1 Immunoexpression Identified by Fine Needle Aspirates. (Mei L, Alikhan M, Mujacic I, Parilla M, Antic T) Acta Cytol 2019;63(5):438-444 5 Citations |
| 1 | A case of Coffin-Siris syndrome with severe congenital heart disease and a novel SMARCA4 variant. (Dsouza NR, Zimmermann MT, Geddes GC) Cold Spring Harb Mol Case Stud 2019 Jun;5(3) 11 Citations |
| 2 | The Roles of Hippo Signaling Transducers Yap and Taz in Chromatin Remodeling. (Hillmer RE, Link BA) Cells 2019 May 24;8(5) 46 Citations |
| 1 | Gene expression of TWIST1 and ZBTB16 is regulated by methylation modifications during the osteoblastic differentiation of mesenchymal stem cells. (Marofi F, Vahedi G, Solali S, Alivand M, Salarinasab S, Zadi Heydarabad M, Farshdousti Hagh M) J Cell Physiol 2019 May;234(5):6230-6243 39 Citations |
| 1 | Interplay between interferon regulatory factor 1 and BRD4 in the regulation of PD-L1 in pancreatic stellate cells. (Ebine K, Kumar K, Pham TN, Shields MA, Collier KA, Shang M, DeCant BT, Urrutia R, Hwang RF, Grimaldo S, Principe DR, Grippo PJ, Bentrem DJ, Munshi HG) Sci Rep 2018 Sep 05;8(1):13225 33 Citations |
| 2 | Crosstalk between PKCα and PI3K/AKT Signaling Is Tumor Suppressive in the Endometrium. (Hsu AH, Lum MA, Shim KS, Frederick PJ, Morrison CD, Chen B, Lele SM, Sheinin YM, Daikoku T, Dey SK, Leone G, Black AR, Black JD) Cell Rep 2018 Jul 17;24(3):655-669 37 Citations |
| 1 | Exome sequencing of 85 Williams-Beuren syndrome cases rules out coding variation as a major contributor to remaining variance in social behavior. (Kopp ND, Parrish PCR, Lugo M, Dougherty JD, Kozel BA) Mol Genet Genomic Med 2018 Sep;6(5):749-765 8 Citations |
| 1 | CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia. (Pulikkan JA, Hegde M, Ahmad HM, Belaghzal H, Illendula A, Yu J, O'Hagan K, Ou J, Muller-Tidow C, Wolfe SA, Zhu LJ, Dekker J, Bushweller JH, Castilla LH) Cell 2018 Jun 28;174(1):172-186.e21 62 Citations |
| 1 | Inactivation of CDK12 Delineates a Distinct Immunogenic Class of Advanced Prostate Cancer. (Wu YM, Cieślik M, Lonigro RJ, Vats P, Reimers MA, Cao X, Ning Y, Wang L, Kunju LP, de Sarkar N, Heath EI, Chou J, Feng FY, Nelson PS, de Bono JS, Zou W, Montgomery B, Alva A, PCF/SU2C International Prostate Cancer Dream Team, Robinson DR, Chinnaiyan AM) Cell 2018 Jun 14;173(7):1770-1782.e14 436 Citations |
| 2 | YAP1-TEAD1 signaling controls angiogenesis and mitochondrial biogenesis through PGC1α. (Mammoto A, Muyleart M, Kadlec A, Gutterman D, Mammoto T) Microvasc Res 2018 Sep;119:73-83 44 Citations |
| 2 | Nitric oxide antagonism to glioblastoma photodynamic therapy and mitigation thereof by BET bromodomain inhibitor JQ1. (Fahey JM, Stancill JS, Smith BC, Girotti AW) J Biol Chem 2018 Apr 06;293(14):5345-5359 48 Citations |
| 1 | Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function. (Wan L, Xu K, Wei Y, Zhang J, Han T, Fry C, Zhang Z, Wang YV, Huang L, Yuan M, Xia W, Chang WC, Huang WC, Liu CL, Chang YC, Liu J, Wu Y, Jin VX, Dai X, Guo J, Liu J, Jiang S, Li J, Asara JM, Brown M, Hung MC, Wei W) Mol Cell 2018 Jan 18;69(2):279-291.e5 147 Citations |
| 3 | Development and Validation of 2D Difference Intensity Analysis for Chemical Library Screening by Protein-Detected NMR Spectroscopy. (Egner JM, Jensen DR, Olp MD, Kennedy NW, Volkman BF, Peterson FC, Smith BC, Hill RB) Chembiochem 2018 Mar 02;19(5):448-458 11 Citations |
| 1 | Metabolically Derived Lysine Acylations and Neighboring Modifications Tune the Binding of the BET Bromodomains to Histone H4. (Olp MD, Zhu N, Smith BC) Biochemistry 2017 Oct 17;56(41):5485-5495 21 Citations |
| 3 | Twist1 in Hypoxia-induced Pulmonary Hypertension through Transforming Growth Factor-β-Smad Signaling. (Mammoto T, Muyleart M, Konduri GG, Mammoto A) Am J Respir Cell Mol Biol 2018 Feb;58(2):194-207 75 Citations |
| 1 | DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes. (Morrison EA, Sanchez JC, Ronan JL, Farrell DP, Varzavand K, Johnson JK, Gu BX, Crabtree GR, Musselman CA) Nat Commun 2017 Jul 14;8:16080 56 Citations |
| 1 | Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis. (Zhang X, Chiang HC, Wang Y, Zhang C, Smith S, Zhao X, Nair SJ, Michalek J, Jatoi I, Lautner M, Oliver B, Wang H, Petit A, Soler T, Brunet J, Mateo F, Angel Pujana M, Poggi E, Chaldekas K, Isaacs C, Peshkin BN, Ochoa O, Chedin F, Theoharis C, Sun LZ, Curiel TJ, Elledge R, Jin VX, Hu Y, Li R) Nat Commun 2017 Jun 26;8:15908 124 Citations |
| 1 | Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail. (Mahmoud MM, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J, Ariaans M, Francis SE, Van der Heiden K, Ridger V, Evans PC) Sci Rep 2017 Jun 13;7(1):3375 145 Citations |
| 1 | Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation. (Liu H, Dowdle JA, Khurshid S, Sullivan NJ, Bertos N, Rambani K, Mair M, Daniel P, Wheeler E, Tang X, Toth K, Lause M, Harrigan ME, Eiring K, Sullivan C, Sullivan MJ, Chang SW, Srivastava S, Conway JS, Kladney R, McElroy J, Bae S, Lu Y, Tofigh A, Saleh SMI, Fernandez SA, Parvin JD, Coppola V, Macrae ER, Majumder S, Shapiro CL, Yee LD, Ramaswamy B, Hallett M, Ostrowski MC, Park M, Chamberlin HM, Leone G) Dev Cell 2017 May 22;41(4):392-407.e6 25 Citations |
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| 1 | Inherited germline ATRX mutation in two brothers with ATR-X syndrome and osteosarcoma. (Ji J, Quindipan C, Parham D, Shen L, Ruble D, Bootwalla M, Maglinte DT, Gai X, Saitta SC, Biegel JA, Mascarenhas L) Am J Med Genet A 2017 May;173(5):1390-1395 28 Citations |
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| 1 | Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles. (Farshidfar F, Zheng S, Gingras MC, Newton Y, Shih J, Robertson AG, Hinoue T, Hoadley KA, Gibb EA, Roszik J, Covington KR, Wu CC, Shinbrot E, Stransky N, Hegde A, Yang JD, Reznik E, Sadeghi S, Pedamallu CS, Ojesina AI, Hess JM, Auman JT, Rhie SK, Bowlby R, Borad MJ, Cancer Genome Atlas Network, Zhu AX, Stuart JM, Sander C, Akbani R, Cherniack AD, Deshpande V, Mounajjed T, Foo WC, Torbenson MS, Kleiner DE, Laird PW, Wheeler DA, McRee AJ, Bathe OF, Andersen JB, Bardeesy N, Roberts LR, Kwong LN) Cell Rep 2017 Mar 14;18(11):2780-2794 391 Citations |
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| 2 | Role of Twist1 Phosphorylation in Angiogenesis and Pulmonary Fibrosis. (Mammoto T, Jiang A, Jiang E, Mammoto A) Am J Respir Cell Mol Biol 2016 Nov;55(5):633-644 39 Citations |
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| 1 | Polymorphisms in MMP9 and SIPA1 are associated with increased risk of nodal metastases in early-stage cervical cancer. (Brooks R, Kizer N, Nguyen L, Jaishuen A, Wanat K, Nugent E, Grigsby P, Allsworth JE, Rader JS) Gynecol Oncol 2010 Mar;116(3):539-43 34 Citations |
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| 1 | Microsatellite instability and epigenetic inactivation of MLH1 and outcome of patients with endometrial carcinomas of the endometrioid type. (Zighelboim I, Goodfellow PJ, Gao F, Gibb RK, Powell MA, Rader JS, Mutch DG) J Clin Oncol 2007 May 20;25(15):2042-8 178 Citations |
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| 1 | Suppression of Huntington's disease pathology in Drosophila by human single-chain Fv antibodies. (Wolfgang WJ, Miller TW, Webster JM, Huston JS, Thompson LM, Marsh JL, Messer A) Proc Natl Acad Sci U S A 2005 Aug 09;102(32):11563-8 133 Citations |
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