Medical College of Wisconsin
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Yi-Guang Chen PhD

Yi-Guang Chen PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Endocrinology


  • Molecular signatures differentiate immune states in type 1 diabetic families. (Chen YG, Cabrera SM, Jia S, Kaldunski ML, Kramer J, Cheong S, Geoffrey R, Roethle MF, Woodliff JE, Greenbaum CJ, Wang X, Hessner MJ) Diabetes 2014 Nov;63(11):3960-73 PMID 24760139
  • Gene targeting in NOD mouse embryos using zinc-finger nucleases. (Chen YG, Forsberg MH, Khaja S, Ciecko AE, Hessner MJ, Geurts AM) Diabetes 2014 Jan;63(1):68-74 PMID 23974926
  • Temporal induction of immunoregulatory processes coincides with age-dependent resistance to viral-induced type 1 diabetes. (Chen YG, Mordes JP, Blankenhorn EP, Kashmiri H, Kaldunski ML, Jia S, Geoffrey R, Wang X, Hessner MJ) Genes Immun 2013 Sep;14(6):387-400 PMID 23739610
  • Genetic control of murine invariant natural killer T cells maps to multiple type 1 diabetes regions. (Tsaih SW, Khaja S, Ciecko AE, MacKinney E, Chen YG) Genes Immun 2013 Sep;14(6):380-6 PMID 23719031
  • Biobreeding rat islets exhibit reduced antioxidative defense and N-acetyl cysteine treatment delays type 1 diabetes. (Bogdani M, Henschel AM, Kansra S, Fuller JM, Geoffrey R, Jia S, Kaldunski ML, Pavletich S, Prosser S, Chen YG, Lernmark A, Hessner MJ) J Endocrinol 2013 Feb;216(2):111-23 PMID 23111281
  • Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse. (Bobbala D, Chen XL, Leblanc C, Mayhue M, Stankova J, Tanaka T, Chen YG, Ilangumaran S, Ramanathan S) Diabetologia 2012 Nov;55(11):3010-20 PMID 22890824
  • Subcongenic analyses reveal complex interactions between distal chromosome 4 genes controlling diabetogenic B cells and CD4 T cells in nonobese diabetic mice. (Stolp J, Chen YG, Cox SL, Henck V, Zhang W, Tsaih SW, Chapman H, Stearns T, Serreze DV, Silveira PA) J Immunol 2012 Aug 1;189(3):1406-17 PMID 22732593
  • Comparative genetics: synergizing human and NOD mouse studies for identifying genetic causation of type 1 diabetes. (Driver JP, Chen YG, Mathews CE) Rev Diabet Stud 2012;9(4):169-87 PMID 23804259
  • Genetic control of murine invariant natural killer T-cell development dynamically differs dependent on the examined tissue type. (Chen YG, Tsaih SW, Serreze DV) Genes Immun 2012 Feb;13(2):164-74 PMID 21938016
  • Testing the role of P2X7 receptors in the development of type 1 diabetes in nonobese diabetic mice. (Chen YG, Scheuplein F, Driver JP, Hewes AA, Reifsnyder PC, Leiter EH, Serreze DV) J Immunol 2011 Apr 1;186(7):4278-84 PMID 21357538
  • Unmasking genes in a type 1 diabetes-resistant mouse strain that enhances pathogenic CD8 T-cell responses. (Driver JP, Chen YG, Zhang W, Asrat S, Serreze DV) Diabetes 2011 Apr;60(4):1354-9 PMID 21307079
  • Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease. (Driver JP, Serreze DV, Chen YG) Semin Immunopathol 2011 Jan;33(1):67-87 PMID 20424843
  • Invariant natural killer T-cell control of type 1 diabetes: a dendritic cell genetic decision of a silver bullet or Russian roulette. (Driver JP, Scheuplein F, Chen YG, Grier AE, Wilson SB, Serreze DV) Diabetes 2010 Feb;59(2):423-32 PMID 19903740
  • A recombinant heavy chain antibody approach blocks ART2 mediated deletion of an iNKT cell population that upon activation inhibits autoimmune diabetes. (Scheuplein F, Rissiek B, Driver JP, Chen YG, Koch-Nolte F, Serreze DV) J Autoimmun 2010 Mar;34(2):145-54 PMID 19796917
  • Idd9/11 genetic locus regulates diabetogenic activity of CD4 T-cells in nonobese diabetic (NOD) mice. (Chen YG, Scheuplein F, Osborne MA, Tsaih SW, Chapman HD, Serreze DV) Diabetes 2008 Dec;57(12):3273-80 PMID 18776136
  • Selective delivery of beta cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in NOD mice. (Mukhopadhaya A, Hanafusa T, Jarchum I, Chen YG, Iwai Y, Serreze DV, Steinman RM, Tarbell KV, DiLorenzo TP) Proc Natl Acad Sci U S A 2008 Apr 29;105(17):6374-9 PMID 18430797
  • Subcongenic analysis of genetic basis for impaired development of invariant NKT cells in NOD mice. (Chen YG, Driver JP, Silveira PA, Serreze DV) Immunogenetics 2007 Sep;59(9):705-12 PMID 17619875
  • Cellular expression requirements for inhibition of type 1 diabetes by a dominantly protective major histocompatibility complex haplotype. (Chen YG, Silveira PA, Osborne MA, Chapman HD, Serreze DV) Diabetes 2007 Feb;56(2):424-30 PMID 17259387
  • Partial versus full allogeneic hemopoietic chimerization is a preferential means to inhibit type 1 diabetes as the latter induces generalized immunosuppression. (Serreze DV, Osborne MA, Chen YG, Chapman HD, Pearson T, Brehm MA, Greiner DL) J Immunol 2006 Nov 15;177(10):6675-84 PMID 17082580
  • CD38 is required for the peripheral survival of immunotolerogenic CD4+ invariant NK T cells in nonobese diabetic mice. (Chen YG, Chen J, Osborne MA, Chapman HD, Besra GS, Porcelli SA, Leiter EH, Wilson SB, Serreze DV) J Immunol 2006 Sep 1;177(5):2939-47 PMID 16920929
  • Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion. (Chen J, Chen YG, Reifsnyder PC, Schott WH, Lee CH, Osborne M, Scheuplein F, Haag F, Koch-Nolte F, Serreze DV, Leiter EH) J Immunol 2006 Apr 15;176(8):4590-9 PMID 16585549
  • Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: II. Immunologic analysis. (Lee CH, Chen YG, Chen J, Reifsnyder PC, Serreze DV, Clare-Salzler M, Rodriguez M, Wasserfall C, Atkinson MA, Leiter EH) Diabetes 2006 Jan;55(1):171-8 PMID 16380490
  • Of mice and men: use of animal models to identify possible interventions for the prevention of autoimmune type 1 diabetes in humans. (Serreze DV, Chen YG) Trends Immunol 2005 Nov;26(11):603-7 PMID 16140038
  • Activated NKT cells inhibit autoimmune diabetes through tolerogenic recruitment of dendritic cells to pancreatic lymph nodes. (Chen YG, Choisy-Rossi CM, Holl TM, Chapman HD, Besra GS, Porcelli SA, Shaffer DJ, Roopenian D, Wilson SB, Serreze DV) J Immunol 2005 Feb 1;174(3):1196-204 PMID 15661873
  • Molecular cloning and sequencing of the human heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase from bone marrow culture. (Omasa T, Chen YG, Mantalaris A, Tsai YC, Wu JH) DNA Seq 2002 Jun;13(3):133-7 PMID 12391722
  • A cDNA from human bone marrow encoding a protein exhibiting homology to the ATP1gamma1/PLM/MAT8 family of transmembrane proteins. (Omasa T, Chen YG, Mantalaris A, Wu JH) Biochim Biophys Acta 2001 Jan 26;1517(2):307-10 PMID 11342114
  • Expression of mPer1 and mPer2, two mammalian clock genes, in murine bone marrow. (Chen YG, Mantalaris A, Bourne P, Keng P, Wu JH) Biochem Biophys Res Commun 2000 Sep 24;276(2):724-8 PMID 11027538
  • Preparation of Der p 1 specific monoclonal antibodies and use in a two-site-ELISA to detect Der p 1 allergen. (Chien TI, Chen YG, Chiang BL) J Microbiol Immunol Infect 2000 Jun;33(2):87-92 PMID 10917877
  • Characterization of monoclonal antibodies against hepatitis C virus nonstructural protein 3: different antigenic determinants from human B cells. (Ou-Yang P, Chiang BL, Hwang LH, Chen YG, Yang PM, Chi WK, Chen PJ, Chen DS) J Med Virol 1999 Apr;57(4):345-50 PMID 10089044
  • Grants and Awards

  • Genetic Engineering of the Idd3 Type 1 Diabetes Locus (#9208459 02/01/2014 - 01/31/2016) Sponsor: NIH Allergy and Infectious Diseases
  • Role of the iNKT-Dendritic Cell Axis in Type 1 Diabetes in NOD Mice (#9206531 09/01/2010 - 08/31/2014) Sponsor: NIH Diabetes, Digestive and Kidney Diseases
  • The Role of CD137 in Type 1 Diabetes (#9306330 12/16/2013 - 12/15/2014) Sponsor: Research Affairs Committee
  • Advancing New Discoveries in Translational Research Through the Collaborative and Pilot Studies Program (#9520196 04/01/2011 - 03/31/2016) PI of Novel Immunotherapy Delays the Onset of Type I Diabetes in NOD Mice (#5520300)
  • Last update: 04/25/2014