Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Cecilia J. Hillard PhD

Cecilia J. Hillard PhD

Associate Dean, Center Director, Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Pharmacology

Member of the Cancer Center
Member of the Neuroscience Research Center
Member of the Comprehensive Injury Center


Research Experience

  • Anxiety
  • Brain
  • Cannabidiol
  • Cannabinoid Receptor Agonists
  • Cannabinoid Receptor Modulators
  • Cannabinoids
  • Carrier Proteins
  • Cells, Cultured
  • Cocaine
  • Corticosterone
  • Depression
  • Endocannabinoids
  • Mice
  • Microglia
  • Models, Animal
  • Neurons
  • Obesity
  • Rats, Sprague-Dawley
  • Receptor, Cannabinoid, CB1
  • Receptor, Cannabinoid, CB2
  • Receptors, Cannabinoid
  • Receptors, Drug
  • Restraint, Physical
  • Signal Transduction
  • Stress, Physiological
  • Stress, Psychological
  • Publications

  • Recent Trends in Cyclic Vomiting Syndrome - Associated Hospitalizations with Liberalization of Cannabis Use in the State of Colorado. (Bhandari S, Jha P, Lisdahl KM, Hillard CJ, Venkatesan T) Intern Med J 2018 Nov 13 PMID: 30426628 11/15/2018    
  • Revisiting cannabinoid receptor 2 expression and function in murine retina. (Borowska-Fielding J, Murataeva N, Smith B, Szczesniak AM, Leishman E, Daily L, Toguri JT, Hillard CJ, Romero J, Bradshaw H, Kelly MEM, Straiker A) Neuropharmacology 2018 10;141:21-31 PMID: 30121200 PMCID: PMC6314309 08/20/2018    
  • Role of endocannabinoids in the hippocampus and amygdala in emotional memory and plasticity. (Segev A, Korem N, Mizrachi Zer-Aviv T, Abush H, Lange R, Sauber G, Hillard CJ, Akirav I) Neuropsychopharmacology 2018 09;43(10):2017-2027 PMID: 29977073 PMCID: PMC6098035 07/07/2018    
  • Role for fatty acid amide hydrolase (FAAH) in the leptin-mediated effects on feeding and energy balance. (Balsevich G, Sticht M, Bowles NP, Singh A, Lee TTY, Li Z, Chelikani PK, Lee FS, Borgland SL, Hillard CJ, McEwen BS, Hill MN) Proc Natl Acad Sci U S A 2018 07 17;115(29):7605-7610 PMID: 29967158 PMCID: PMC6055171 07/04/2018    
  • The Lateral Habenula Directs Coping Styles Under Conditions of Stress via Recruitment of the Endocannabinoid System. (Berger AL, Henricks AM, Lugo JM, Wright HR, Warrick CR, Sticht MA, Morena M, Bonilla I, Laredo SA, Craft RM, Parsons LH, Grandes PR, Hillard CJ, Hill MN, McLaughlin RJ) Biol Psychiatry 2018 Oct 15;84(8):611-623 PMID: 29887035 PMCID: PMC6162143 06/12/2018       2 Citations
  • Cannabinoid CB receptors in the mouse brain: relevance for Alzheimer's disease. (López A, Aparicio N, Pazos MR, Grande MT, Barreda-Manso MA, Benito-Cuesta I, Vázquez C, Amores M, Ruiz-Pérez G, García-García E, Beatka M, Tolón RM, Dittel BN, Hillard CJ, Romero J) J Neuroinflammation 2018 May 24;15(1):158 PMID: 29793509 PMCID: PMC5968596 05/26/2018       4 Citations
  • Chronic treatment with URB597 ameliorates post-stress symptoms in a rat model of PTSD. (Fidelman S, Mizrachi Zer-Aviv T, Lange R, Hillard CJ, Akirav I) Eur Neuropsychopharmacol 2018 05;28(5):630-642 PMID: 29519609 03/10/2018       6 Citations
  • Psychobiological Responses to Aerobic Exercise in Individuals With Posttraumatic Stress Disorder. (Crombie KM, Brellenthin AG, Hillard CJ, Koltyn KF) J Trauma Stress 2018 Feb;31(1):134-145 PMID: 29388710 02/02/2018    
  • Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization in the Prelimbic Cortex. (McReynolds JR, Doncheck EM, Li Y, Vranjkovic O, Graf EN, Ogasawara D, Cravatt BF, Baker DA, Liu QS, Hillard CJ, Mantsch JR) Biol Psychiatry 2017 Oct 06 PMID: 29100630 PMCID: PMC5889367 11/05/2017    
  • Increase in the circulating endocannabinoid 2-arachidonoylglycerol is associated with gabapentin use in septic ICU patients. (Raff H, Kramer DJ, Hillard CJ) Endocrine 2017 10;58(1):203-204 PMID: 28875451 09/07/2017    
  • 17β-Estradiol Potentiates the Reinstatement of Cocaine Seeking in Female Rats: Role of the Prelimbic Prefrontal Cortex and Cannabinoid Type-1 Receptors. (Doncheck EM, Urbanik LA, DeBaker MC, Barron LM, Liddiard GT, Tuscher JJ, Frick KM, Hillard CJ, Mantsch JR) Neuropsychopharmacology 2018 03;43(4):781-790 PMID: 28825421 PMCID: PMC5809785 08/22/2017    
  • Endocannabinoid Transport Proteins: Discovery of Tools to Study Sterol Carrier Protein-2. (Hillard CJ, Huang H, Vogt CD, Rodrigues BE, Neumann TS, Sem DS, Schroeder F, Cunningham CW) Methods Enzymol 2017;593:99-121 PMID: 28750817 07/29/2017       6 Citations
  • Cannabinoid Receptor 1 and Fatty Acid Amide Hydrolase Contribute to Operant Sensation Seeking in Mice. (Helfand AI, Olsen CM, Hillard CJ) Int J Mol Sci 2017 Jul 27;18(8) PMID: 28749428 PMCID: PMC5578025 07/28/2017       1 Citations
  • Host interleukin 6 production regulates inflammation but not tryptophan metabolism in the brain during murine GVHD. (Belle L, Zhou V, Stuhr KL, Beatka M, Siebers EM, Knight JM, Lawlor MW, Weaver C, Hashizume M, Hillard CJ, Drobyski WR) JCI Insight 2017 Jul 20;2(14) PMID: 28724796 PMCID: PMC5518565 07/21/2017    
  • Circulating Endocannabinoids: From Whence Do They Come and Where are They Going? (Hillard CJ) Neuropsychopharmacology 2018 Jan;43(1):155-172 PMID: 28653665 PMCID: PMC5719092 06/28/2017       14 Citations
  • Role of beta-catenin and endocannabinoids in the nucleus accumbens in extinction in rats exposed to shock and reminders. (Korem N, Lange R, Hillard CJ, Akirav I) Neuroscience 2017 08 15;357:285-294 PMID: 28624572 06/19/2017       4 Citations
  • Altered striatal endocannabinoid signaling in a transgenic mouse model of spinocerebellar ataxia type-3. (Rodríguez-Cueto C, Hernández-Gálvez M, Hillard CJ, Maciel P, Valdeolivas S, Ramos JA, Gómez-Ruiz M, Fernández-Ruiz J) PLoS One 2017;12(4):e0176521 PMID: 28448548 PMCID: PMC5407801 04/28/2017    
  • Endocannabinoid and Opioid System Interactions in Exercise-Induced Hypoalgesia. (Crombie KM, Brellenthin AG, Hillard CJ, Koltyn KF) Pain Med 2018 01 01;19(1):118-123 PMID: 28387833 04/08/2017       7 Citations
  • Endocannabinoid and Mood Responses to Exercise in Adults with Varying Activity Levels. (Brellenthin AG, Crombie KM, Hillard CJ, Koltyn KF) Med Sci Sports Exerc 2017 08;49(8):1688-1696 PMID: 28319590 03/21/2017       6 Citations
  • Upregulation of fatty acid amide hydrolase in the dorsal periaqueductal gray is associated with neuropathic pain and reduced heart rate in rats. (Dean C, Hillard CJ, Seagard JL, Hopp FA, Hogan QH) Am J Physiol Regul Integr Comp Physiol 2017 04 01;312(4):R585-R596 PMID: 28148494 02/06/2017    
  • Endocannabinoid Signaling and the Hypothalamic-Pituitary-Adrenal Axis. (Hillard CJ, Beatka M, Sarvaideo J) Compr Physiol 2016 12 06;7(1):1-15 PMID: 28134998 PMCID: PMC5871916 01/31/2017       8 Citations
  • Dysregulation of the endocannabinoid signaling system in the cerebellum and brainstem in a transgenic mouse model of spinocerebellar ataxia type-3. (Rodríguez-Cueto C, Hernández-Gálvez M, Hillard CJ, Maciel P, García-García L, Valdeolivas S, Pozo MA, Ramos JA, Gómez-Ruiz M, Fernández-Ruiz J) Neuroscience 2016 Dec 17;339:191-209 PMID: 27717809 11/05/2016       6 Citations
  • FAAH Gene Variation Moderates Stress Response and Symptom Severity in Patients with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence. (Spagnolo PA, Ramchandani VA, Schwandt ML, Kwako LE, George DT, Mayo LM, Hillard CJ, Heilig M) Alcohol Clin Exp Res 2016 11;40(11):2426-2434 PMID: 27716956 PMCID: PMC5748341 10/21/2016       14 Citations
  • Seeing through the smoke: Human and animal studies of cannabis use and endocannabinoid signalling in corticolimbic networks. (Silveira MM, Arnold JC, Laviolette SR, Hillard CJ, Celorrio M, Aymerich MS, Adams WK) Neurosci Biobehav Rev 2017 05;76(Pt B):380-395 PMID: 27639448 PMCID: PMC5350061 09/19/2016       4 Citations
  • Marijuana users do not have increased healthcare utilization: A National Health and Nutrition Examination Survey (NHANES) study. (Bhandari S, Hillard CJ, Venkatesan T) Eur J Intern Med 2016 Oct;34:e9-e10 PMID: 27499177 08/09/2016       2 Citations
  • Endocannabinoid Responses To Exercise In Low, Moderate, And High Active Individuals: 3765 Board #204 June 4, 8: 00 AM - 9: 30 AM. (Brellenthin AG, Crombie KM, Hillard CJ, Koltyn KF) Med Sci Sports Exerc 2016 May;48(5 Suppl 1):1052-3 PMID: 27362131 07/01/2016    
  • Fatty acid amide hydrolase inhibition for the symptomatic relief of Parkinson's disease. (Celorrio M, Fernández-Suárez D, Rojo-Bustamante E, Echeverry-Alzate V, Ramírez MJ, Hillard CJ, López-Moreno JA, Maldonado R, Oyarzábal J, Franco R, Aymerich MS) Brain Behav Immun 2016 Oct;57:94-105 PMID: 27318096 06/19/2016       17 Citations
  • Components of the cannabinoid system in the dorsal periaqueductal gray are related to resting heart rate. (Dean C, Hillard CJ, Seagard JL, Hopp FA, Hogan QH) Am J Physiol Regul Integr Comp Physiol 2016 08 01;311(2):R254-62 PMID: 27280429 PMCID: PMC4982395 06/10/2016       3 Citations
  • Endocannabinoid-related lipids are increased during an episode of cyclic vomiting syndrome. (Venkatesan T, Zadvornova Y, Raff H, Hillard CJ) Neurogastroenterol Motil 2016 Sep;28(9):1409-18 PMID: 27098832 PMCID: PMC5002231 04/22/2016       10 Citations
  • Sustained glucocorticoid exposure recruits cortico-limbic CRH signaling to modulate endocannabinoid function. (Gray JM, Wilson CD, Lee TT, Pittman QJ, Deussing JM, Hillard CJ, McEwen BS, Schulkin J, Karatsoreos IN, Patel S, Hill MN) Psychoneuroendocrinology 2016 Apr;66:151-8 PMID: 26821211 PMCID: PMC4788523 01/29/2016       19 Citations
  • The Endocannabinoid Signaling System in the CNS: A Primer. (Hillard CJ) Int Rev Neurobiol 2015;125:1-47 PMID: 26638763 12/08/2015       21 Citations
  • Sleep Restriction Enhances the Daily Rhythm of Circulating Levels of Endocannabinoid 2-Arachidonoylglycerol. (Hanlon EC, Tasali E, Leproult R, Stuhr KL, Doncheck E, de Wit H, Hillard CJ, Van Cauter E) Sleep 2016 Mar 01;39(3):653-64 PMID: 26612385 PMCID: PMC4763355 11/28/2015       20 Citations
  • The endocannabinoid system in guarding against fear, anxiety and stress. (Lutz B, Marsicano G, Maldonado R, Hillard CJ) Nat Rev Neurosci 2015 12;16(12):705-18 PMID: 26585799 PMCID: PMC5871913 11/21/2015       90 Citations
  • CB1 receptor antagonism blocks stress-potentiated reinstatement of cocaine seeking in rats. (McReynolds JR, Doncheck EM, Vranjkovic O, Ganzman GS, Baker DA, Hillard CJ, Mantsch JR) Psychopharmacology (Berl) 2016 Jan;233(1):99-109 PMID: 26455361 PMCID: PMC4703460 10/13/2015       16 Citations
  • Endocannabinoids and the Endocrine System in Health and Disease. (Hillard CJ) Handb Exp Pharmacol 2015;231:317-39 PMID: 26408166 09/27/2015       8 Citations
  • Endocannabinoid regulation of amyloid-induced neuroinflammation. (Vázquez C, Tolón RM, Grande MT, Caraza M, Moreno M, Koester EC, Villaescusa B, Ruiz-Valdepeñas L, Fernández-Sánchez FJ, Cravatt BF, Hillard CJ, Romero J) Neurobiol Aging 2015 Nov;36(11):3008-3019 PMID: 26362942 09/13/2015       5 Citations
  • Disruption of peri-adolescent endocannabinoid signaling modulates adult neuroendocrine and behavioral responses to stress in male rats. (Lee TT, Hill MN, Hillard CJ, Gorzalka BB) Neuropharmacology 2015 Dec;99:89-97 PMID: 26192544 07/21/2015       10 Citations
  • Circulating endocannabinoids during hematopoietic stem cell transplantation: A pilot study. (Knight JM, Szabo A, Zhao S, Lyness JM, Sahler OJ, Liesveld JL, Sander T, Rizzo JD, Hillard CJ, Moynihan JA) Neurobiol Stress 2015;2:44-50 PMID: 26114153 PMCID: PMC4476410 06/27/2015    
  • An endocannabinoid system is present in the mouse olfactory epithelium but does not modulate olfaction. (Hutch CR, Hillard CJ, Jia C, Hegg CC) Neuroscience 2015 Aug 06;300:539-53 PMID: 26037800 PMCID: PMC4485596 06/04/2015       3 Citations
  • Endocannabinoids regulate the activity of astrocytic hemichannels and the microglial response against an injury: In vivo studies. (Vázquez C, Tolón RM, Pazos MR, Moreno M, Koester EC, Cravatt BF, Hillard CJ, Romero J) Neurobiol Dis 2015 Jul;79:41-50 PMID: 25917763 04/29/2015       18 Citations
  • A peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated metabolic syndrome. (Bowles NP, Karatsoreos IN, Li X, Vemuri VK, Wood JA, Li Z, Tamashiro KL, Schwartz GJ, Makriyannis AM, Kunos G, Hillard CJ, McEwen BS, Hill MN) Proc Natl Acad Sci U S A 2015 Jan 06;112(1):285-90 PMID: 25535367 PMCID: PMC4291642 12/24/2014       37 Citations
  • Attenuation of cystitis and pain sensation in mice lacking fatty acid amide hydrolase. (Wang ZY, Wang P, Hillard CJ, Bjorling DE) J Mol Neurosci 2015 Apr;55(4):968-76 PMID: 25374388 PMCID: PMC4355044 11/07/2014       4 Citations
  • Circadian rhythm of circulating levels of the endocannabinoid 2-arachidonoylglycerol. (Hanlon EC, Tasali E, Leproult R, Stuhr KL, Doncheck E, de Wit H, Hillard CJ, Van Cauter E) J Clin Endocrinol Metab 2015 Jan;100(1):220-6 PMID: 25368979 PMCID: PMC5399498 11/05/2014       22 Citations
  • Monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model. (Fernández-Suárez D, Celorrio M, Riezu-Boj JI, Ugarte A, Pacheco R, González H, Oyarzabal J, Hillard CJ, Franco R, Aymerich MS) Neurobiol Aging 2014 Nov;35(11):2603-2616 PMID: 24973119 06/29/2014       32 Citations
  • Stress regulates endocannabinoid-CB1 receptor signaling. (Hillard CJ) Semin Immunol 2014 Oct;26(5):380-8 PMID: 24882055 PMCID: PMC4247817 06/03/2014       34 Citations
  • Differential muscle hypertrophy is associated with satellite cell numbers and Akt pathway activation following activin type IIB receptor inhibition in Mtm1 p.R69C mice. (Lawlor MW, Viola MG, Meng H, Edelstein RV, Liu F, Yan K, Luna EJ, Lerch-Gaggl A, Hoffmann RG, Pierson CR, Buj-Bello A, Lachey JL, Pearsall S, Yang L, Hillard CJ, Beggs AH) Am J Pathol 2014 Jun;184(6):1831-42 PMID: 24726641 PMCID: PMC4044712 04/15/2014       11 Citations
  • Sterol carrier protein-2: binding protein for endocannabinoids. (Liedhegner ES, Vogt CD, Sem DS, Cunningham CW, Hillard CJ) Mol Neurobiol 2014 Aug;50(1):149-58 PMID: 24510313 PMCID: PMC4450258 02/11/2014       14 Citations
  • Endocannabinoid signaling in hypothalamic-pituitary-adrenocortical axis recovery following stress: effects of indirect agonists and comparison of male and female mice. (Roberts CJ, Stuhr KL, Hutz MJ, Raff H, Hillard CJ) Pharmacol Biochem Behav 2014 Feb;117:17-24 PMID: 24316201 PMCID: PMC3929302 12/10/2013       26 Citations
  • Endocannabinoid signaling in the etiology and treatment of major depressive illness. (Hillard CJ, Liu QS) Curr Pharm Des 2014;20(23):3795-811 PMID: 24180398 PMCID: PMC4002665 11/05/2013       20 Citations
  • Brain region-specific changes in N-acylethanolamine contents with time of day. (Liedhegner ES, Sasman A, Hillard CJ) J Neurochem 2014 Feb;128(4):491-506 PMID: 24138639 PMCID: PMC3946166 10/22/2013       9 Citations
  • Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the World Trade Center attacks. (Hill MN, Bierer LM, Makotkine I, Golier JA, Galea S, McEwen BS, Hillard CJ, Yehuda R) Psychoneuroendocrinology 2013 Dec;38(12):2952-61 PMID: 24035186 PMCID: PMC3870889 09/17/2013       79 Citations
  • Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: role of 5HT(1A) and CB2 receptors. (Pazos MR, Mohammed N, Lafuente H, Santos M, Martínez-Pinilla E, Moreno E, Valdizan E, Romero J, Pazos A, Franco R, Hillard CJ, Alvarez FJ, Martínez-Orgado J) Neuropharmacology 2013 Aug;71:282-91 PMID: 23587650 04/17/2013       68 Citations
  • Upregulation of CB₁ receptor binding in the ventromedial prefrontal cortex promotes proactive stress-coping strategies following chronic stress exposure. (McLaughlin RJ, Hill MN, Dang SS, Wainwright SR, Galea LA, Hillard CJ, Gorzalka BB) Behav Brain Res 2013 Jan 15;237:333-7 PMID: 23047058 PMCID: PMC3501995 10/11/2012       28 Citations
  • Temporal changes in N-acylethanolamine content and metabolism throughout the peri-adolescent period. (Lee TT, Hill MN, Hillard CJ, Gorzalka BB) Synapse 2013 Jan;67(1):4-10 PMID: 22987804 PMCID: PMC3510355 09/19/2012       34 Citations
  • Disruption of fatty acid amide hydrolase activity prevents the effects of chronic stress on anxiety and amygdalar microstructure. (Hill MN, Kumar SA, Filipski SB, Iverson M, Stuhr KL, Keith JM, Cravatt BF, Hillard CJ, Chattarji S, McEwen BS) Mol Psychiatry 2013 Oct;18(10):1125-35 PMID: 22776900 PMCID: PMC4148304 07/11/2012       94 Citations
  • Acute stress increases circulating anandamide and other N-acylethanolamines in healthy humans. (Dlugos A, Childs E, Stuhr KL, Hillard CJ, de Wit H) Neuropsychopharmacology 2012 Oct;37(11):2416-27 PMID: 22763622 PMCID: PMC3442338 07/06/2012       72 Citations
  • Circulating endocannabinoid concentrations and sexual arousal in women. (Klein C, Hill MN, Chang SC, Hillard CJ, Gorzalka BB) J Sex Med 2012 Jun;9(6):1588-601 PMID: 22462722 PMCID: PMC3856894 04/03/2012    
  • Serum contents of endocannabinoids are correlated with blood pressure in depressed women. (Ho WS, Hill MN, Miller GE, Gorzalka BB, Hillard CJ) Lipids Health Dis 2012 Feb 28;11:32 PMID: 22373123 PMCID: PMC3334711 03/01/2012       22 Citations
  • Prefrontal cortical anandamide signaling coordinates coping responses to stress through a serotonergic pathway. (McLaughlin RJ, Hill MN, Bambico FR, Stuhr KL, Gobbi G, Hillard CJ, Gorzalka BB) Eur Neuropsychopharmacol 2012 Sep;22(9):664-71 PMID: 22325231 PMCID: PMC3366159 02/14/2012       54 Citations
  • Swim stress differentially affects limbic contents of 2-arachidonoylglycerol and 2-oleoylglycerol. (Roberts CJ, Stuhr KL, Hillard CJ) Neuroscience 2012 Mar 01;204:74-82 PMID: 22192839 PMCID: PMC3288304 12/24/2011       8 Citations
  • Contributions of endocannabinoid signaling to psychiatric disorders in humans: genetic and biochemical evidence. (Hillard CJ, Weinlander KM, Stuhr KL) Neuroscience 2012 Mar 01;204:207-29 PMID: 22123166 PMCID: PMC3288440 11/30/2011       78 Citations
  • Chronic, noninvasive glucocorticoid administration suppresses limbic endocannabinoid signaling in mice. (Bowles NP, Hill MN, Bhagat SM, Karatsoreos IN, Hillard CJ, McEwen BS) Neuroscience 2012 Mar 01;204:83-9 PMID: 21939741 PMCID: PMC3697830 09/24/2011       32 Citations
  • Acute restraint stress enhances hippocampal endocannabinoid function via glucocorticoid receptor activation. (Wang M, Hill MN, Zhang L, Gorzalka BB, Hillard CJ, Alger BE) J Psychopharmacol 2012 Jan;26(1):56-70 PMID: 21890595 PMCID: PMC3373303 09/06/2011       77 Citations
  • Cannabinoid receptor involvement in stress-induced cocaine reinstatement: potential interaction with noradrenergic pathways. (Vaughn LK, Mantsch JR, Vranjkovic O, Stroh G, Lacourt M, Kreutter M, Hillard CJ) Neuroscience 2012 Mar 01;204:117-24 PMID: 21871539 PMCID: PMC3422566 08/30/2011       28 Citations
  • Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response. (Hill MN, McLaughlin RJ, Pan B, Fitzgerald ML, Roberts CJ, Lee TT, Karatsoreos IN, Mackie K, Viau V, Pickel VM, McEwen BS, Liu QS, Gorzalka BB, Hillard CJ) J Neurosci 2011 Jul 20;31(29):10506-15 PMID: 21775596 PMCID: PMC3179266 07/22/2011       162 Citations
  • Alterations in corticolimbic dendritic morphology and emotional behavior in cannabinoid CB1 receptor-deficient mice parallel the effects of chronic stress. (Hill MN, Hillard CJ, McEwen BS) Cereb Cortex 2011 Sep;21(9):2056-64 PMID: 21263035 PMCID: PMC3155602 01/26/2011       65 Citations
  • Natural and synthetic corticosteroids inhibit uptake 2-mediated transport in CNS neurons. (Hill JE, Makky K, Shrestha L, Hillard CJ, Gasser PJ) Physiol Behav 2011 Aug 03;104(2):306-11 PMID: 21081135 11/18/2010       13 Citations
  • Sex difference in cell proliferation in developing rat amygdala mediated by endocannabinoids has implications for social behavior. (Krebs-Kraft DL, Hill MN, Hillard CJ, McCarthy MM) Proc Natl Acad Sci U S A 2010 Nov 23;107(47):20535-40 PMID: 21059913 PMCID: PMC2996668 11/10/2010       51 Citations
  • Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model. (Ghosh A, Chandran K, Kalivendi SV, Joseph J, Antholine WE, Hillard CJ, Kanthasamy A, Kanthasamy A, Kalyanaraman B) Free Radic Biol Med 2010 Dec 01;49(11):1674-84 PMID: 20828611 PMCID: PMC4020411 09/11/2010       88 Citations
  • Inhibition of fatty acid amide hydrolase suppresses referred hyperalgesia induced by bladder inflammation. (Merriam FV, Wang ZY, Hillard CJ, Stuhr KL, Bjorling DE) BJU Int 2011 Oct;108(7):1145-9 PMID: 20804480 PMCID: PMC3505723 09/02/2010       21 Citations
  • Fast feedback inhibition of the HPA axis by glucocorticoids is mediated by endocannabinoid signaling. (Evanson NK, Tasker JG, Hill MN, Hillard CJ, Herman JP) Endocrinology 2010 Oct;151(10):4811-9 PMID: 20702575 PMCID: PMC2946139 08/13/2010       163 Citations
  • Deficiency in endocannabinoid signaling in the nucleus accumbens induced by chronic unpredictable stress. (Wang W, Sun D, Pan B, Roberts CJ, Sun X, Hillard CJ, Liu QS) Neuropsychopharmacology 2010 Oct;35(11):2249-61 PMID: 20664582 PMCID: PMC3055309 07/29/2010       58 Citations
  • Endocannabinoid modulation of hyperaemia evoked by physiologically relevant stimuli in the rat primary somatosensory cortex. (Ho WS, Patel S, Thompson JR, Roberts CJ, Stuhr KL, Hillard CJ) Br J Pharmacol 2010 Jun;160(3):736-46 PMID: 20590576 PMCID: PMC2931572 07/02/2010       7 Citations
  • Endocannabinoid signalling: has it got rhythm? (Vaughn LK, Denning G, Stuhr KL, de Wit H, Hill MN, Hillard CJ) Br J Pharmacol 2010 Jun;160(3):530-43 PMID: 20590563 PMCID: PMC2931554 07/02/2010       49 Citations
  • Retrograde release of endocannabinoids inhibits presynaptic GABA release to second-order baroreceptive neurons in NTS. (Chen CY, Bonham AC, Dean C, Hopp FA, Hillard CJ, Seagard JL) Auton Neurosci 2010 Dec 08;158(1-2):44-50 PMID: 20580326 PMCID: PMC2976795 06/29/2010       14 Citations
  • Endogenous cannabinoid signaling is essential for stress adaptation. (Hill MN, McLaughlin RJ, Bingham B, Shrestha L, Lee TT, Gray JM, Hillard CJ, Gorzalka BB, Viau V) Proc Natl Acad Sci U S A 2010 May 18;107(20):9406-11 PMID: 20439721 PMCID: PMC2889099 05/05/2010       178 Citations
  • Rapid elevations in limbic endocannabinoid content by glucocorticoid hormones in vivo. (Hill MN, Karatsoreos IN, Hillard CJ, McEwen BS) Psychoneuroendocrinology 2010 Oct;35(9):1333-8 PMID: 20399021 PMCID: PMC2914801 04/20/2010       90 Citations
  • Estrogenic regulation of limbic cannabinoid receptor binding. (Riebe CJ, Hill MN, Lee TT, Hillard CJ, Gorzalka BB) Psychoneuroendocrinology 2010 Sep;35(8):1265-9 PMID: 20207489 PMCID: PMC2933663 03/09/2010       59 Citations
  • Obesity-related dyslipidemia associated with FAAH, independent of insulin response, in multigenerational families of Northern European descent. (Zhang Y, Sonnenberg GE, Baye TM, Littrell J, Gunnell J, DeLaForest A, MacKinney E, Hillard CJ, Kissebah AH, Olivier M, Wilke RA) Pharmacogenomics 2009 Dec;10(12):1929-39 PMID: 19958092 PMCID: PMC3003434 12/05/2009       14 Citations
  • Oxidants induce alternative splicing of alpha-synuclein: Implications for Parkinson's disease. (Kalivendi SV, Yedlapudi D, Hillard CJ, Kalyanaraman B) Free Radic Biol Med 2010 Feb 01;48(3):377-83 PMID: 19857570 PMCID: PMC4485429 10/28/2009       30 Citations
  • The therapeutic potential of the endocannabinoid system for the development of a novel class of antidepressants. (Hill MN, Hillard CJ, Bambico FR, Patel S, Gorzalka BB, Gobbi G) Trends Pharmacol Sci 2009 Sep;30(9):484-93 PMID: 19732971 09/08/2009       98 Citations
  • Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic-pituitary-adrenal axis. (Hill MN, McLaughlin RJ, Morrish AC, Viau V, Floresco SB, Hillard CJ, Gorzalka BB) Neuropsychopharmacology 2009 Dec;34(13):2733-45 PMID: 19710634 PMCID: PMC3197779 08/28/2009       159 Citations
  • Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling. (Pan B, Wang W, Long JZ, Sun D, Hillard CJ, Cravatt BF, Liu QS) J Pharmacol Exp Ther 2009 Nov;331(2):591-7 PMID: 19666749 PMCID: PMC2775254 08/12/2009       108 Citations
  • Endogenous cannabinoid signaling is required for voluntary exercise-induced enhancement of progenitor cell proliferation in the hippocampus. (Hill MN, Titterness AK, Morrish AC, Carrier EJ, Lee TT, Gil-Mohapel J, Gorzalka BB, Hillard CJ, Christie BR) Hippocampus 2010 Apr;20(4):513-23 PMID: 19489006 PMCID: PMC2847038 06/03/2009       64 Citations
  • Differential endocannabinoid regulation of baroreflex-evoked sympathoinhibition in normotensive versus hypertensive rats. (Brozoski DT, Dean C, Hopp FA, Hillard CJ, Seagard JL) Auton Neurosci 2009 Oct 05;150(1-2):82-93 PMID: 19464961 PMCID: PMC3815570 05/26/2009       21 Citations
  • Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress. (Hill MN, Miller GE, Carrier EJ, Gorzalka BB, Hillard CJ) Psychoneuroendocrinology 2009 Sep;34(8):1257-62 PMID: 19394765 PMCID: PMC2716432 04/28/2009       117 Citations
  • Role of endocannabinoid signaling in anxiety and depression. (Patel S, Hillard CJ) Curr Top Behav Neurosci 2009;1:347-71 PMID: 21104391 PMCID: PMC3808114 01/01/2009       18 Citations
  • D2 dopamine receptor activation facilitates endocannabinoid-mediated long-term synaptic depression of GABAergic synaptic transmission in midbrain dopamine neurons via cAMP-protein kinase A signaling. (Pan B, Hillard CJ, Liu QS) J Neurosci 2008 Dec 24;28(52):14018-30 PMID: 19109485 PMCID: PMC2656602 12/26/2008       88 Citations
  • Differential effects of the antidepressants tranylcypromine and fluoxetine on limbic cannabinoid receptor binding and endocannabinoid contents. (Hill MN et al.) J Neural Transm 2009 Feb;116(2):141 PMID: 19093190 12/19/2008    
  • Genetic variation in cannabinoid receptor 1 (CNR1) is associated with derangements in lipid homeostasis, independent of body mass index. (Baye TM, Zhang Y, Smith E, Hillard CJ, Gunnell J, Myklebust J, James R, Kissebah AH, Olivier M, Wilke RA) Pharmacogenomics 2008 Nov;9(11):1647-56 PMID: 19018721 PMCID: PMC2784739 11/21/2008       33 Citations
  • Differential effects of the antidepressants tranylcypromine and fluoxetine on limbic cannabinoid receptor binding and endocannabinoid contents. (Hill MN, Ho WS, Hillard CJ, Gorzalka BB) J Neural Transm (Vienna) 2008 Dec;115(12):1673-9 PMID: 18974922 PMCID: PMC2992975 11/01/2008       40 Citations
  • Role of cannabinoids and endocannabinoids in cerebral ischemia. (Hillard CJ) Curr Pharm Des 2008;14(23):2347-61 PMID: 18781985 PMCID: PMC2581413 09/11/2008       81 Citations
  • Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment. (Hill MN, Carrier EJ, McLaughlin RJ, Morrish AC, Meier SE, Hillard CJ, Gorzalka BB) J Neurochem 2008 Sep;106(6):2322-36 PMID: 18643796 PMCID: PMC2606621 07/23/2008       129 Citations
  • Mediation of cannabidiol anti-inflammation in the retina by equilibrative nucleoside transporter and A2A adenosine receptor. (Liou GI, Auchampach JA, Hillard CJ, Zhu G, Yousufzai B, Mian S, Khan S, Khalifa Y) Invest Ophthalmol Vis Sci 2008 Dec;49(12):5526-31 PMID: 18641283 PMCID: PMC2588644 07/22/2008       65 Citations
  • Adaptations in endocannabinoid signaling in response to repeated homotypic stress: a novel mechanism for stress habituation. (Patel S, Hillard CJ) Eur J Neurosci 2008 Jun;27(11):2821-9 PMID: 18588527 PMCID: PMC2593941 07/01/2008       102 Citations
  • Regulation of endocannabinoid signaling by stress: implications for stress-related affective disorders. (Gorzalka BB, Hill MN, Hillard CJ) Neurosci Biobehav Rev 2008 Aug;32(6):1152-60 PMID: 18433869 04/25/2008       133 Citations
  • Serum endocannabinoid content is altered in females with depressive disorders: a preliminary report. (Hill MN, Miller GE, Ho WS, Gorzalka BB, Hillard CJ) Pharmacopsychiatry 2008 Mar;41(2):48-53 PMID: 18311684 PMCID: PMC3422568 03/04/2008       129 Citations
  • Endocannabinoid signaling mediates cocaine-induced inhibitory synaptic plasticity in midbrain dopamine neurons. (Pan B, Hillard CJ, Liu QS) J Neurosci 2008 Feb 06;28(6):1385-97 PMID: 18256258 02/08/2008       100 Citations
  • Characterization of epoxyeicosatrienoic acid binding site in U937 membranes using a novel radiolabeled agonist, 20-125i-14,15-epoxyeicosa-8(Z)-enoic acid. (Yang W, Tuniki VR, Anjaiah S, Falck JR, Hillard CJ, Campbell WB) J Pharmacol Exp Ther 2008 Mar;324(3):1019-27 PMID: 18171909 01/04/2008       64 Citations
  • Glial expression of cannabinoid CB(2) receptors and fatty acid amide hydrolase are beta amyloid-linked events in Down's syndrome. (Núñez E, Benito C, Tolón RM, Hillard CJ, Griffin WS, Romero J) Neuroscience 2008 Jan 02;151(1):104-10 PMID: 18068305 12/11/2007       58 Citations
  • Prolonged glucocorticoid treatment decreases cannabinoid CB1 receptor density in the hippocampus. (Hill MN, Carrier EJ, Ho WS, Shi L, Patel S, Gorzalka BB, Hillard CJ) Hippocampus 2008;18(2):221-6 PMID: 18058925 12/07/2007       67 Citations
  • Brain uptake and utilization of fatty acids, lipids & lipoproteins: recommendations for future research. (Katz R, Hamilton JA, Pownall HJ, Deckelbaum RJ, Hillard CJ, Leboeuf RC, Watkins PA) J Mol Neurosci 2007 Sep;33(1):146-50 PMID: 17901559 09/29/2007       5 Citations
  • Studies of anandamide accumulation inhibitors in cerebellar granule neurons: comparison to inhibition of fatty acid amide hydrolase. (Hillard CJ, Shi L, Tuniki VR, Falck JR, Campbell WB) J Mol Neurosci 2007 Sep;33(1):18-24 PMID: 17901541 PMCID: PMC2248273 09/29/2007       26 Citations
  • Brain uptake and utilization of fatty acids, lipids and lipoproteins: application to neurological disorders. (Hamilton JA, Hillard CJ, Spector AA, Watkins PA) J Mol Neurosci 2007 Sep;33(1):2-11 PMID: 17901539 09/29/2007       32 Citations
  • Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619. (Hillard CJ, Ho WS, Thompson J, Gauthier KM, Wheelock CE, Huang H, Hammock BD) Br J Pharmacol 2007 Nov;152(5):691-8 PMID: 17891162 PMCID: PMC2190024 09/25/2007       23 Citations
  • Effects of acute and repeated restraint stress on endocannabinoid content in the amygdala, ventral striatum, and medial prefrontal cortex in mice. (Rademacher DJ, Meier SE, Shi L, Ho WS, Jarrahian A, Hillard CJ) Neuropharmacology 2008 Jan;54(1):108-16 PMID: 17675104 08/07/2007       148 Citations
  • Electroconvulsive shock treatment differentially modulates cortical and subcortical endocannabinoid activity. (Hill MN, Barr AM, Ho WS, Carrier EJ, Gorzalka BB, Hillard CJ) J Neurochem 2007 Oct;103(1):47-56 PMID: 17561935 06/15/2007       29 Citations
  • Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells. (Maresz K, Pryce G, Ponomarev ED, Marsicano G, Croxford JL, Shriver LP, Ledent C, Cheng X, Carrier EJ, Mann MK, Giovannoni G, Pertwee RG, Yamamura T, Buckley NE, Hillard CJ, Lutz B, Baker D, Dittel BN) Nat Med 2007 Apr;13(4):492-7 PMID: 17401376 04/03/2007       240 Citations
  • Cannabinoid CB1 and CB2 receptors and fatty acid amide hydrolase are specific markers of plaque cell subtypes in human multiple sclerosis. (Benito C, Romero JP, Tolón RM, Clemente D, Docagne F, Hillard CJ, Guaza C, Romero J) J Neurosci 2007 Feb 28;27(9):2396-402 PMID: 17329437 03/03/2007       175 Citations
  • Interactions between endocannabinoids and stress-induced decreased sensitivity to natural reward. (Rademacher DJ, Hillard CJ) Prog Neuropsychopharmacol Biol Psychiatry 2007 Apr 13;31(3):633-41 PMID: 17258369 PMCID: PMC1876712 01/30/2007       59 Citations
  • Involvement of the endocannabinoid system in the ability of long-term tricyclic antidepressant treatment to suppress stress-induced activation of the hypothalamic-pituitary-adrenal axis. (Hill MN, Ho WS, Sinopoli KJ, Viau V, Hillard CJ, Gorzalka BB) Neuropsychopharmacology 2006 Dec;31(12):2591-9 PMID: 16710317 05/20/2006       88 Citations
  • Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression. (Carrier EJ, Auchampach JA, Hillard CJ) Proc Natl Acad Sci U S A 2006 May 16;103(20):7895-900 PMID: 16672367 PMCID: PMC1472541 05/05/2006       214 Citations
  • Modulators of endocannabinoid enzymic hydrolysis and membrane transport. (Ho WS, Hillard CJ) Handb Exp Pharmacol 2005(168):187-207 PMID: 16596775 04/07/2006       30 Citations
  • Pharmacological evaluation of cannabinoid receptor ligands in a mouse model of anxiety: further evidence for an anxiolytic role for endogenous cannabinoid signaling. (Patel S, Hillard CJ) J Pharmacol Exp Ther 2006 Jul;318(1):304-11 PMID: 16569753 03/30/2006       270 Citations
  • Fetomaternal cross talk in the placental vascular bed: control of coagulation by trophoblast cells. (Sood R, Kalloway S, Mast AE, Hillard CJ, Weiler H) Blood 2006 Apr 15;107(8):3173-80 PMID: 16380449 PMCID: PMC1895751 12/29/2005       61 Citations
  • Endocannabinoids in neuroimmunology and stress. (Carrier EJ, Patel S, Hillard CJ) Curr Drug Targets CNS Neurol Disord 2005 Dec;4(6):657-65 PMID: 16375683 12/27/2005       48 Citations
  • Chronic corticosterone treatment increases the endocannabinoid 2-arachidonylglycerol in the rat amygdala. (Hill MN, Ho WS, Meier SE, Gorzalka BB, Hillard CJ) Eur J Pharmacol 2005 Dec 28;528(1-3):99-102 PMID: 16324692 12/06/2005       29 Citations
  • Reticulocyte 15-lipoxygenase-I is important in acetylcholine-induced endothelium-dependent vasorelaxation in rabbit aorta. (Tang X, Holmes BB, Nithipatikom K, Hillard CJ, Kuhn H, Campbell WB) Arterioscler Thromb Vasc Biol 2006 Jan;26(1):78-84 PMID: 16239596 10/22/2005       29 Citations
  • Sepiapterin attenuates 1-methyl-4-phenylpyridinium-induced apoptosis in neuroblastoma cells transfected with neuronal NOS: role of tetrahydrobiopterin, nitric oxide, and proteasome activation. (Shang T, Kotamraju S, Zhao H, Kalivendi SV, Hillard CJ, Kalyanaraman B) Free Radic Biol Med 2005 Oct 15;39(8):1059-74 PMID: 16198233 10/04/2005       24 Citations
  • Modulation of the cannabinoid CB2 receptor in microglial cells in response to inflammatory stimuli. (Maresz K, Carrier EJ, Ponomarev ED, Hillard CJ, Dittel BN) J Neurochem 2005 Oct;95(2):437-45 PMID: 16086683 08/10/2005       272 Citations
  • Death-associated protein kinase as a sensor of mitochondrial membrane potential: role of lysosome in mitochondrial toxin-induced cell death. (Shang T, Joseph J, Hillard CJ, Kalyanaraman B) J Biol Chem 2005 Oct 14;280(41):34644-53 PMID: 16085644 08/09/2005       30 Citations
  • Lipids and drugs of abuse. (Hillard CJ) Life Sci 2005 Aug 19;77(14):1531-42 PMID: 15946699 06/11/2005       12 Citations
  • Accumulation of anandamide: evidence for cellular diversity. (Hillard CJ, Jarrahian A) Neuropharmacology 2005 Jun;48(8):1072-8 PMID: 15910883 05/25/2005       32 Citations
  • Effects of endocannabinoids on discharge of baroreceptive NTS neurons. (Seagard JL, Hopp FA, Hillard CJ, Dean C) Neurosci Lett 2005 Jun 24;381(3):334-9 PMID: 15896495 05/18/2005       22 Citations
  • Inhibition of restraint stress-induced neural and behavioural activation by endogenous cannabinoid signalling. (Patel S, Roelke CT, Rademacher DJ, Hillard CJ) Eur J Neurosci 2005 Feb;21(4):1057-69 PMID: 15787710 03/25/2005       197 Citations
  • A glial endogenous cannabinoid system is upregulated in the brains of macaques with simian immunodeficiency virus-induced encephalitis. (Benito C, Kim WK, Chavarría I, Hillard CJ, Mackie K, Tolón RM, Williams K, Romero J) J Neurosci 2005 Mar 09;25(10):2530-6 PMID: 15758162 03/11/2005       102 Citations
  • U-46619 but not serotonin increases endocannabinoid content in middle cerebral artery: evidence for functional relevance. (Rademacher DJ, Patel S, Ho WS, Savoie AM, Rusch NJ, Gauthier KM, Hillard CJ) Am J Physiol Heart Circ Physiol 2005 Jun;288(6):H2694-701 PMID: 15695564 02/08/2005       22 Citations
  • Characterization of phospholipase activity of the Pseudomonas aeruginosa type III cytotoxin, ExoU. (Sato H, Feix JB, Hillard CJ, Frank DW) J Bacteriol 2005 Feb;187(3):1192-5 PMID: 15659695 PMCID: PMC545705 01/22/2005       48 Citations
  • 2-arachidonoylglycerol: a novel inhibitor of androgen-independent prostate cancer cell invasion. (Nithipatikom K, Endsley MP, Isbell MA, Falck JR, Iwamoto Y, Hillard CJ, Campbell WB) Cancer Res 2004 Dec 15;64(24):8826-30 PMID: 15604240 12/18/2004       94 Citations
  • The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity. (Patel S, Carrier EJ, Ho WS, Rademacher DJ, Cunningham S, Reddy DS, Falck JR, Cravatt BF, Hillard CJ) J Lipid Res 2005 Feb;46(2):342-9 PMID: 15576840 12/04/2004       99 Citations
  • Anandamide content is increased and CB1 cannabinoid receptor blockade is protective during transient, focal cerebral ischemia. (Muthian S, Rademacher DJ, Roelke CT, Gross GJ, Hillard CJ) Neuroscience 2004;129(3):743-50 PMID: 15541895 11/16/2004       109 Citations
  • Endothelium-derived 2-arachidonylglycerol: an intermediate in vasodilatory eicosanoid release in bovine coronary arteries. (Gauthier KM, Baewer DV, Hittner S, Hillard CJ, Nithipatikom K, Reddy DS, Falck JR, Campbell WB) Am J Physiol Heart Circ Physiol 2005 Mar;288(3):H1344-51 PMID: 15528233 11/06/2004       58 Citations
  • Waterborne lead exposure affects brain endocannabinoid content in male but not female fathead minnows (Pimephales promelas). (Rademacher DJ, Weber DN, Hillard CJ) Neurotoxicology 2005 Jan;26(1):9-15 PMID: 15527869 11/06/2004       13 Citations
  • Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress. (Hill MN, Patel S, Carrier EJ, Rademacher DJ, Ormerod BK, Hillard CJ, Gorzalka BB) Neuropsychopharmacology 2005 Mar;30(3):508-15 PMID: 15525997 11/05/2004       230 Citations
  • Spatial correlations of laminar BOLD and CBV responses to rat whisker stimulation with neuronal activity localized by Fos expression. (Lu H, Patel S, Luo F, Li SJ, Hillard CJ, Ward BD, Hyde JS) Magn Reson Med 2004 Nov;52(5):1060-8 PMID: 15508149 10/28/2004       83 Citations
  • Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis. (Patel S, Roelke CT, Rademacher DJ, Cullinan WE, Hillard CJ) Endocrinology 2004 Dec;145(12):5431-8 PMID: 15331569 08/28/2004       322 Citations
  • Synergistic interactions between cannabinoids and environmental stress in the activation of the central amygdala. (Patel S, Cravatt BF, Hillard CJ) Neuropsychopharmacology 2005 Mar;30(3):497-507 PMID: 15280883 07/29/2004       106 Citations
  • Dendritically released transmitters cooperate via autocrine and retrograde actions to inhibit afferent excitation in rat brain. (Hirasawa M, Schwab Y, Natah S, Hillard CJ, Mackie K, Sharkey KA, Pittman QJ) J Physiol 2004 Sep 01;559(Pt 2):611-24 PMID: 15254151 PMCID: PMC1665137 07/16/2004       103 Citations
  • Chronic administration of nitric oxide reduces angiotensin II receptor type 1 expression and aldosterone synthesis in zona glomerulosa cells. (Nithipatikom K, Holmes BB, McCoy MJ, Hillard CJ, Campbell WB) Am J Physiol Endocrinol Metab 2004 Nov;287(5):E820-7 PMID: 15198935 06/17/2004       11 Citations
  • Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism. (Carrier EJ, Kearn CS, Barkmeier AJ, Breese NM, Yang W, Nithipatikom K, Pfister SL, Campbell WB, Hillard CJ) Mol Pharmacol 2004 Apr;65(4):999-1007 PMID: 15044630 03/27/2004       248 Citations
  • Production of hydroxyeicosatetraenoic acids and prostaglandins by a novel rat microglial cell line. (Rademacher DJ, Kearn CS, Carrier EJ, Patel S, Delgado MA, Barkmeier A, Klick DE, Breese NM, Pfister SL, Nithipatikom K, Campbell WB, Hillard CJ) J Neuroimmunol 2004 Apr;149(1-2):130-41 PMID: 15020073 03/17/2004       7 Citations
  • 1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric-oxide synthase-derived superoxide. (Shang T, Kotamraju S, Kalivendi SV, Hillard CJ, Kalyanaraman B) J Biol Chem 2004 Apr 30;279(18):19099-112 PMID: 14752097 01/31/2004       48 Citations
  • Alpha-synuclein up-regulation and aggregation during MPP+-induced apoptosis in neuroblastoma cells: intermediacy of transferrin receptor iron and hydrogen peroxide. (Kalivendi SV, Cunningham S, Kotamraju S, Joseph J, Hillard CJ, Kalyanaraman B) J Biol Chem 2004 Apr 09;279(15):15240-7 PMID: 14742448 01/27/2004       103 Citations
  • Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains. (Benito C, Núñez E, Tolón RM, Carrier EJ, Rábano A, Hillard CJ, Romero J) J Neurosci 2003 Dec 03;23(35):11136-41 PMID: 14657172 12/06/2003       365 Citations
  • Anandamide content and interaction of endocannabinoid/GABA modulatory effects in the NTS on baroreflex-evoked sympathoinhibition. (Seagard JL, Dean C, Patel S, Rademacher DJ, Hopp FA, Schmeling WT, Hillard CJ) Am J Physiol Heart Circ Physiol 2004 Mar;286(3):H992-1000 PMID: 14615281 11/15/2003       50 Citations
  • Cellular accumulation of anandamide: consensus and controversy. (Hillard CJ, Jarrahian A) Br J Pharmacol 2003 Nov;140(5):802-8 PMID: 12970089 PMCID: PMC1574088 09/13/2003       185 Citations
  • The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase. (Patel S, Wohlfeil ER, Rademacher DJ, Carrier EJ, Perry LJ, Kundu A, Falck JR, Nithipatikom K, Campbell WB, Hillard CJ) Br J Pharmacol 2003 Jul;139(5):1005-13 PMID: 12839875 PMCID: PMC1573928 07/04/2003       104 Citations
  • Differential regulation of the endocannabinoids anandamide and 2-arachidonylglycerol within the limbic forebrain by dopamine receptor activity. (Patel S, Rademacher DJ, Hillard CJ) J Pharmacol Exp Ther 2003 Sep;306(3):880-8 PMID: 12808005 06/17/2003       117 Citations
  • The mechanism of action of the Pseudomonas aeruginosa-encoded type III cytotoxin, ExoU. (Sato H, Frank DW, Hillard CJ, Feix JB, Pankhaniya RR, Moriyama K, Finck-Barbançon V, Buchaklian A, Lei M, Long RM, Wiener-Kronish J, Sawa T) EMBO J 2003 Jun 16;22(12):2959-69 PMID: 12805211 PMCID: PMC162142 06/14/2003       221 Citations
  • Hemisynthesis and preliminary evaluation of novel endocannabinoid analogues. (El Fangour S, Balas L, Rossi JC, Fedenyuk A, Gretskaya N, Bobrov M, Bezuglov V, Hillard CJ, Durand T) Bioorg Med Chem Lett 2003 Jun 16;13(12):1977-80 PMID: 12781177 06/05/2003       7 Citations
  • 1-Methyl-4-phenylpyridinium accumulates in cerebellar granule neurons via organic cation transporter 3. (Shang T, Uihlein AV, Van Asten J, Kalyanaraman B, Hillard CJ) J Neurochem 2003 Apr;85(2):358-67 PMID: 12675912 04/05/2003       60 Citations
  • Cannabinoid-induced Fos expression within A10 dopaminergic neurons. (Patel S, Hillard CJ) Brain Res 2003 Feb 14;963(1-2):15-25 PMID: 12560108 02/01/2003       52 Citations
  • 1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide. (Kalivendi SV, Kotamraju S, Cunningham S, Shang T, Hillard CJ, Kalyanaraman B) Biochem J 2003 Apr 01;371(Pt 1):151-64 PMID: 12523938 PMCID: PMC1223270 01/14/2003       80 Citations
  • Microinjection of a cannabinoid receptor antagonist into the NTS increases baroreflex duration in dogs. (Rademacher DJ, Patel S, Hopp FA, Dean C, Hillard CJ, Seagard JL) Am J Physiol Heart Circ Physiol 2003 May;284(5):H1570-6 PMID: 12521935 01/11/2003       30 Citations
  • The CB1 receptor antagonist SR141716 enhances stimulus-induced activation of the primary somatosensory cortex of the rat. (Patel S, Gerrits R, Muthian S, Greene AS, Hillard CJ) Neurosci Lett 2002 Dec 25;335(2):95-8 PMID: 12459507 12/03/2002       12 Citations
  • Fatty acid amide hydrolase localization in the human central nervous system: an immunohistochemical study. (Romero J, Hillard CJ, Calero M, Rábano A) Brain Res Mol Brain Res 2002 Apr 30;100(1-2):85-93 PMID: 12008024 05/15/2002       61 Citations
  • Cannabinoid-receptor-independent cell signalling by N-acylethanolamines. (Berdyshev EV, Schmid PC, Krebsbach RJ, Hillard CJ, Huang C, Chen N, Dong Z, Schmid HH) Biochem J 2001 Nov 15;360(Pt 1):67-75 PMID: 11695993 PMCID: PMC1222203 11/07/2001       66 Citations
  • Cannabinoid receptor agonists inhibit depolarization-induced calcium influx in cerebellar granule neurons. (Nogueron MI, Porgilsson B, Schneider WE, Stucky CL, Hillard CJ) J Neurochem 2001 Oct;79(2):371-81 PMID: 11677265 10/26/2001       31 Citations
  • Cannabinoids inhibit emesis through CB1 receptors in the brainstem of the ferret. (Van Sickle MD, Oland LD, Ho W, Hillard CJ, Mackie K, Davison JS, Sharkey KA) Gastroenterology 2001 Oct;121(4):767-74 PMID: 11606489 10/19/2001       173 Citations
  • Cannabinoid CB(1) receptor agonists produce cerebellar dysfunction in mice. (Patel S, Hillard CJ) J Pharmacol Exp Ther 2001 May;297(2):629-37 PMID: 11303052 04/17/2001       68 Citations
  • Endothelium-independent, ouabain-sensitive relaxation of bovine coronary arteries by EETs. (Pratt PF, Li P, Hillard CJ, Kurian J, Campbell WB) Am J Physiol Heart Circ Physiol 2001 Mar;280(3):H1113-21 PMID: 11179054 02/17/2001       49 Citations
  • The cellular uptake of anandamide is coupled to its breakdown by fatty-acid amide hydrolase. (Deutsch DG, Glaser ST, Howell JM, Kunz JS, Puffenbarger RA, Hillard CJ, Abumrad N) J Biol Chem 2001 Mar 09;276(10):6967-73 PMID: 11118429 12/19/2000       183 Citations
  • The movement of N-arachidonoylethanolamine (anandamide) across cellular membranes. (Hillard CJ, Jarrahian A) Chem Phys Lipids 2000 Nov;108(1-2):123-34 PMID: 11106786 12/07/2000       160 Citations
  • Inhibition of small intestinal secretion by cannabinoids is CB1 receptor-mediated in rats. (Tyler K, Hillard CJ, Greenwood-Van Meerveld B) Eur J Pharmacol 2000 Dec 08;409(2):207-11 PMID: 11104836 12/06/2000       51 Citations
  • Endocannabinoids and vascular function. (Hillard CJ) J Pharmacol Exp Ther 2000 Jul;294(1):27-32 PMID: 10871291 06/28/2000       141 Citations
  • Structure-activity relationships among N-arachidonylethanolamine (Anandamide) head group analogues for the anandamide transporter. (Jarrahian A, Manna S, Edgemond WS, Campbell WB, Hillard CJ) J Neurochem 2000 Jun;74(6):2597-606 PMID: 10820223 05/23/2000       128 Citations
  • Biochemistry and pharmacology of the endocannabinoids arachidonylethanolamide and 2-arachidonylglycerol. (Hillard CJ) Prostaglandins Other Lipid Mediat 2000 Apr;61(1-2):3-18 PMID: 10785538 04/29/2000       171 Citations
  • Synthesis and characterization of a fluorescent substrate for the N-arachidonoylethanolamine (anandamide) transmembrane carrier. (Muthian S, Nithipatikom K, Campbell WB, Hillard CJ) J Pharmacol Exp Ther 2000 Apr;293(1):289-95 PMID: 10734181 03/29/2000       31 Citations
  • Effects of CB(1) cannabinoid receptor activation on cerebellar granule cell nitric oxide synthase activity. (Hillard CJ, Muthian S, Kearn CS) FEBS Lett 1999 Oct 08;459(2):277-81 PMID: 10518035 10/13/1999       76 Citations
  • Cannabinoid CB1 receptor of cat cerebral arterial muscle functions to inhibit L-type Ca2+ channel current. (Gebremedhin D, Lange AR, Campbell WB, Hillard CJ, Harder DR) Am J Physiol 1999 06;276(6):H2085-93 PMID: 10362691 06/11/1999       203 Citations
  • Relationships between ligand affinities for the cerebellar cannabinoid receptor CB1 and the induction of GDP/GTP exchange. (Kearn CS, Greenberg MJ, DiCamelli R, Kurzawa K, Hillard CJ) J Neurochem 1999 Jun;72(6):2379-87 PMID: 10349847 06/01/1999       95 Citations
  • Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1). (Hillard CJ, Manna S, Greenberg MJ, DiCamelli R, Ross RA, Stevenson LA, Murphy V, Pertwee RG, Campbell WB) J Pharmacol Exp Ther 1999 Jun;289(3):1427-33 PMID: 10336536 05/21/1999       267 Citations
  • Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry. (Tsou K, Nogueron MI, Muthian S, Sañudo-Pena MC, Hillard CJ, Deutsch DG, Walker JM) Neurosci Lett 1998 Oct 02;254(3):137-40 PMID: 10214976 04/24/1999       209 Citations
  • Human platelets and polymorphonuclear leukocytes synthesize oxygenated derivatives of arachidonylethanolamide (anandamide): their affinities for cannabinoid receptors and pathways of inactivation. (Edgemond WS, Hillard CJ, Falck JR, Kearn CS, Campbell WB) Mol Pharmacol 1998 Jul;54(1):180-8 PMID: 9658204 07/11/1998       106 Citations
  • Synthesis and characterization of diazomethylarachidonyl ketone: an irreversible inhibitor of N-arachidonylethanolamine amidohydrolase. (Edgemond WS, Greenberg MJ, McGinley PJ, Muthian S, Campbell WB, Hillard CJ) J Pharmacol Exp Ther 1998 Jul;286(1):184-90 PMID: 9655859 07/10/1998       40 Citations
  • N-arachidonylethanolamide relaxation of bovine coronary artery is not mediated by CB1 cannabinoid receptor. (Pratt PF, Hillard CJ, Edgemond WS, Campbell WB) Am J Physiol 1998 Jan;274(1 Pt 2):H375-81 PMID: 9458889 02/12/1998       93 Citations
  • Biochemistry and pharmacology of arachidonylethanolamide, a putative endogenous cannabinoid. (Hillard CJ, Campbell WB) J Lipid Res 1997 Dec;38(12):2383-98 PMID: 9458263 02/11/1998       91 Citations
  • Arachidonylethanolamide (anandamide) binds with low affinity to dihydropyridine binding sites in brain membranes. (Jarrahian A, Hillard CJ) Prostaglandins Leukot Essent Fatty Acids 1997 Dec;57(6):551-4 PMID: 9431821 02/07/1998       24 Citations
  • Accumulation of N-arachidonoylethanolamine (anandamide) into cerebellar granule cells occurs via facilitated diffusion. (Hillard CJ, Edgemond WS, Jarrahian A, Campbell WB) J Neurochem 1997 Aug;69(2):631-8 PMID: 9231721 08/01/1997       298 Citations
  • The role of nitric oxide in the cerebrovascular response to hypercapnia. (Smith JJ, Lee JG, Hudetz AG, Hillard CJ, Bosnjak ZJ, Kampine JP) Anesth Analg 1997 Feb;84(2):363-9 PMID: 9024030 02/01/1997       17 Citations
  • Immunocytes and abnormal gastrointestinal motor activity during ileitis in dogs. (Jouët P, Sarna SK, Singaram C, Ryan RP, Hillard CJ, Telford GL, Fink J, Henderson JD) Am J Physiol 1995 Dec;269(6 Pt 1):G913-24 PMID: 8572223 12/01/1995       35 Citations
  • Characterization of the kinetics and distribution of N-arachidonylethanolamine (anandamide) hydrolysis by rat brain. (Hillard CJ, Wilkison DM, Edgemond WS, Campbell WB) Biochim Biophys Acta 1995 Aug 03;1257(3):249-56 PMID: 7647100 08/03/1995       206 Citations
  • Laser-Doppler measurement of the effects of halothane and isoflurane on the cerebrovascular CO2 response in the rat. (Lee JG, Smith JJ, Hudetz AG, Hillard CJ, Bosnjak ZJ, Kampine JP) Anesth Analg 1995 Apr;80(4):696-702 PMID: 7893020 04/01/1995       26 Citations
  • Characterization of ligand binding to the cannabinoid receptor of rat brain membranes using a novel method: application to anandamide. (Hillard CJ, Edgemond WS, Campbell WB) J Neurochem 1995 Feb;64(2):677-83 PMID: 7830060 02/01/1995       73 Citations
  • The binding of novel phenolic derivatives of anandamide to brain cannabinoid receptors. (Edgemond WS, Campbell WB, Hillard CJ) Prostaglandins Leukot Essent Fatty Acids 1995 Feb-Mar;52(2-3):83-6 PMID: 7784462 02/01/1995       27 Citations
  • The effects of halothane and isoflurane on cerebrocortical microcirculation and autoregulation as assessed by laser-Doppler flowmetry. (Lee JG, Hudetz AG, Smith JJ, Hillard CJ, Bosnjak ZJ, Kampine JP) Anesth Analg 1994 Jul;79(1):58-65 PMID: 8010455 07/01/1994       52 Citations
  • Decreased adrenal medullary catecholamine release in spontaneously diabetic BB-Wistar rats. Role of hypoglycemia. (Wilke RA, Hillard CJ) Diabetes 1994 May;43(5):724-9 PMID: 8168651 05/01/1994       17 Citations
  • In vitro activation of brain protein kinase C by the cannabinoids. (Hillard CJ, Auchampach JA) Biochim Biophys Acta 1994 Jan 13;1220(2):163-70 PMID: 8312360 01/13/1994       26 Citations
  • Decreased catecholamine secretion from the adrenal medullae of chronically diabetic BB-Wistar rats. (Wilke RA, Riley DA, Lelkes PI, Hillard CJ) Diabetes 1993 Jun;42(6):862-8 PMID: 8495810 06/01/1993       15 Citations
  • Effects of chronic nicotine treatment on the accumulation of [3H]tetraphenylphosphonium by cerebral cortical synaptosomes. (Hillard CJ, Pounds JJ) J Neurochem 1993 Feb;60(2):687-95 PMID: 8419544 02/01/1993       10 Citations
  • Nicotine-induced depolarization of cerebral cortical synaptosomes is dependent upon sodium. (Hillard CJ) Neuropharmacology 1992 Sep;31(9):909-14 PMID: 1436397 09/01/1992       4 Citations
  • Role of guanylate cyclase-cGMP systems in halothane-induced vasodilation in canine cerebral arteries. (Eskinder H, Hillard CJ, Flynn N, Bosnjak ZJ, Kampine JP) Anesthesiology 1992 Sep;77(3):482-7 PMID: 1355637 09/01/1992       25 Citations
  • [3H]tetraphenylphosphonium accumulation in cerebral cortical synaptosomes as a measure of nicotine-induced changes in membrane potential. (Hillard CJ, Pounds JJ) J Pharmacol Exp Ther 1991 Dec;259(3):1118-23 PMID: 1762066 12/01/1991       8 Citations
  • Studies of the effect of nicotine on synaptosomal calcium accumulation using FURA-2. (Hillard CJ, Graf WK) NIDA Res Monogr 1990;105:331-2 PMID: 1876032 01/01/1991       2 Citations
  • Studies of the role of membrane lipid order in the effects of delta 9-tetrahydrocannabinol on adenylate cyclase activation in heart. (Hillard CJ, Pounds JJ, Boyer DR, Bloom AS) J Pharmacol Exp Ther 1990 Mar;252(3):1075-82 PMID: 2156989 03/01/1990       23 Citations
  • Effect of KT-362, a putative intracellular calcium antagonist, on norepinephrine-induced contractions and inositol monophosphate accumulation in canine femoral artery. (Eskinder H, Hillard CJ, Wilke RA, Gross GJ) J Cardiovasc Pharmacol 1989 Mar;13(3):502-7 PMID: 2471898 03/01/1989       15 Citations
  • Alpha adrenoceptor subtypes and receptor reserve in human versus canine saphenous vein: sensitivity to blockade by nitroglycerin. (Eskinder H, Hillard CJ, Olinger GN, Christensen CW, Baker JE, Warltier DC, Gross GJ) J Pharmacol Exp Ther 1988 Dec;247(3):941-8 PMID: 2905005 12/01/1988       9 Citations
  • Effects of delta 9-tetrahydrocannabinol on glucagon receptor coupling to adenylate cyclase in rat liver plasma membranes. (Hillard CJ, Bloom AS, Houslay MD) Biochem Pharmacol 1986 Aug 15;35(16):2797-803 PMID: 3017362 08/15/1986       16 Citations
  • Effects of the cannabinoids on physical properties of brain membranes and phospholipid vesicles: fluorescence studies. (Hillard CJ, Harris RA, Bloom AS) J Pharmacol Exp Ther 1985 Mar;232(3):579-88 PMID: 2983062 03/01/1985       76 Citations
  • The effects of delta 9-tetrahydrocannabinol on serum thyrotropin levels in the rat. (Hillard CJ, Farber NE, Hagen TC, Bloom AS) Pharmacol Biochem Behav 1984 Apr;20(4):547-50 PMID: 6328543 04/01/1984       23 Citations
  • Possible role of prostaglandins in the effects of the cannabinoids on adenylate cyclase activity. (Hillard CJ, Bloom AS) Eur J Pharmacol 1983 Jul 15;91(1):21-7 PMID: 6311573 07/15/1983       19 Citations
  • delta 9-Tetrahydrocannabinol-induced changes in beta-adrenergic receptor binding in mouse cerebral cortex. (Hillard CJ, Bloom AS) Brain Res 1982 Mar 11;235(2):370-7 PMID: 6329417 03/11/1982       24 Citations
  • Last update: 12/08/2018
    jenkins-FCD Prod-299 9ef562391eceb2b8f95265c767fbba1ce5a52fd6