Medical College of Wisconsin
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Justin L. Grobe PhD

Justin L. Grobe PhD profile photo picture

Professor

Institution: Medical College of Wisconsin
Department: Physiology

image of /images/ORCIDiD_icon16x16.png   https://orcid.org/0000-0001-9737-0873

Member of the Cardiovascular Center
Member of the Neuroscience Research Center


I am willing to collaborate on research projects.
I am willing to mentor a junior faculty member.

View Curriculum Vitae

Research Areas of Interest

  • Adiposity
  • Agouti-Related Protein
  • Arcuate Nucleus of Hypothalamus
  • Basal Metabolism
  • Blood Pressure
  • Body Composition
  • Body Water
  • Body Weight
  • Brain
  • Central Nervous System
  • Dehydration
  • Disease Models, Animal
  • Energy Metabolism
  • Hypertension
  • Hypothalamus
  • Infant, Newborn
  • Obesity
  • Placenta
  • Pre-Eclampsia
  • Pregnancy
  • RGS Proteins
  • Receptors, G-Protein-Coupled
  • Renin-Angiotensin System
  • Signal Transduction
  • Sodium
  • Sympathetic Nervous System
  • Vasopressins
  • Water-Electrolyte Balance

    • Research Experience

  • Arginine Vasopressin
  • Blood Pressure
  • Energy Metabolism
  • Gastrointestinal Microbiome
  • Hypertension
  • Hypothalamus
  • Obesity
  • Pre-Eclampsia
  • Pregnancy
  • Receptors, G-Protein-Coupled
  • Renin-Angiotensin System
  • Water-Electrolyte Balance

    • Methodologies and Techniques

  • Analysis of Variance
  • Basal Metabolism
  • Calorimetry
  • Dose-Response Relationship, Drug
  • Eating
  • Energy Metabolism
  • Feeding Behavior
  • Humans
  • Mice
  • Rats
  • Sensitivity and Specificity
  • Statistics

    • Leadership Positions

  • Director, MCW Comprehensive Rodent Metabolic Phenotyping Core
  • Member, MCW MSTP Admissions Committee
  • Vice-Chair, MCW Institutional Animal Care & Use Committee
  • Co-Course Director, MCW INDP 16245 Statistics for Basic Sciences

    • MCW Program / Core Facilities

  • Comprehensive Rodent Metabolic Phenotyping Core

    • Educational Expertise

  • Basal Metabolism
  • Biostatistics
  • Energy Metabolism
  • Hypertension
  • Neurosciences
  • Pre-Eclampsia

    • Publications (137)

  • Genetic Deletion of β-Arrestin 2 From the Subfornical Organ and Other Periventricular Nuclei in the Brain Alters Fluid Homeostasis and Blood Pressure. (Mathieu NM, Tan EE, Reho JJ, Brozoski DT, Muskus PC, Lu KT, Wackman KK, Grobe JL, Nakagawa P, Sigmund CD) Hypertension 2024 Apr 17 PMID: 38629290 04/17/2024    
  • Diet in Food Insecurity: A Mediator of Metabolic Health? (Morselli LL, Amjad R, James R, Kindel TL, Kwitek AE, Williams JS, Grobe JL, Kidambi S) J Endocr Soc 2024 Apr 06;8(6):bvae062 PMID: 38623381 PMCID: PMC11017326 SCOPUS ID: 2-s2.0-85190716270 04/16/2024    
  • Modulatory effects of estrous cycle on ingestive behaviors and energy balance in young adult C57BL/6J mice maintained on a phytoestrogen-free diet. (Reho JJ, Muskus PC, Bennett DM, Grobe CC, Burnett CML, Nakagawa P, Segar JL, Sigmund CD, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2024 Mar 01;326(3):R242-R253 PMID: 38284128 SCOPUS ID: 2-s2.0-85186271298 01/29/2024    
  • Differences in Fluid, Electrolyte, and Energy Balance in C57BL/6J Mice (Mus musculus) in Metabolic Caging at Thermoneutral or Standard Room Temperatures. (Lawton SB, Grobe CC, Reho JJ, Raff H, Thulin JD, Jensen ES, Burnett CM, Segar JL, Grobe JL) J Am Assoc Lab Anim Sci 2024 Mar 01;63(2):190-200 PMID: 38191147 PMCID: PMC11022944 SCOPUS ID: 2-s2.0-85192114074 01/09/2024    
  • Krüppel-like factor 4 in transcriptional control of the three unique isoforms of Agouti-related peptide in mice. (Ritter ML, Wagner VA, Balapattabi K, Opichka MA, Lu KT, Wackman KK, Reho JJ, Keen HL, Kwitek AE, Morselli LL, Geurts AM, Sigmund CD, Grobe JL) Physiol Genomics 2024 Mar 01;56(3):265-275 PMID: 38145289 PMCID: PMC10866620 SCOPUS ID: 2-s2.0-85185200180 12/25/2023    
  • Mitochondrial-targeted antioxidant attenuates preeclampsia-like phenotypes induced by syncytiotrophoblast-specific Gαq signaling. (Opichka MA, Livergood MC, Balapattabi K, Ritter ML, Brozoski DT, Wackman KK, Lu KT, Kozak KN, Wells C, Fogo AB, Gibson-Corley KN, Kwitek AE, Sigmund CD, McIntosh JJ, Grobe JL) Sci Adv 2023 Dec;9(48):eadg8118 PMID: 38039359 PMCID: PMC10691776 SCOPUS ID: 2-s2.0-85178323055 12/01/2023       1 Citation
  • The Power of the Heterogeneous Stock Rat Founder Strains in Modeling Metabolic Disease. (Wagner VA, Holl KL, Clark KC, Reho JJ, Lehmler HJ, Wang K, Grobe JL, Dwinell MR, Raff H, Kwitek AE) Endocrinology 2023 Nov 02;164(12) PMID: 37882530 PMCID: PMC10637104 SCOPUS ID: 2-s2.0-85176509096 10/26/2023    
  • Early-life sodium deprivation programs long-term changes in ingestive behaviors and energy expenditure in C57BL/6J mice. (Ziegler AA, Lawton SBR, Grobe CC, Reho JJ, Freudinger BP, Burnett CML, Nakagawa P, Grobe JL, Segar JL) Am J Physiol Regul Integr Comp Physiol 2023 Nov 01;325(5):R576-R592 PMID: 37720996 PMCID: PMC10866575 SCOPUS ID: 2-s2.0-85174752582 09/18/2023    
  • Sodium and Growth in Preterm Infants: A Review. (Araya BR, Ziegler AA, Grobe CC, Grobe JL, Segar JL) Newborn (Clarksville) 2023;2(2):142-147 PMID: 37614871 PMCID: PMC10445331 08/24/2023    
  • Genetic Ablation of Prorenin Receptor in the Rostral Ventrolateral Medulla Influences Blood Pressure and Hydromineral Balance in Deoxycorticosterone-Salt Hypertension. (Mathieu NM, Fekete EM, Muskus PC, Brozoski DT, Lu KT, Wackman KK, Gomez J, Fang S, Reho JJ, Grobe CC, Vazirabad I, Mouradian GC Jr, Hodges MR, Segar JL, Grobe JL, Sigmund CD, Nakagawa P) Function (Oxf) 2023;4(5):zqad043 PMID: 37609445 PMCID: PMC10440998 SCOPUS ID: 2-s2.0-85168790693 08/23/2023    
  • Angiotensin AT1A receptor signal switching in Agouti-related peptide neurons mediates metabolic rate adaptation during obesity. (Balapattabi K, Yavuz Y, Jiang J, Deng G, Mathieu NM, Ritter ML, Opichka MA, Reho JJ, McCorvy JD, Nakagawa P, Morselli LL, Mouradian GC Jr, Atasoy D, Cui H, Hodges MR, Sigmund CD, Grobe JL) Cell Rep 2023 Aug 29;42(8):112935 PMID: 37540598 PMCID: PMC10530419 SCOPUS ID: 2-s2.0-85169503465 08/04/2023       1 Citation
  • Cardiometabolic Effects of DOCA-Salt in Mice Depend on Ambient Temperature. (Grobe CC, Reho JJ, Brown-Williams D, Ziegler AA, Mathieu NM, Lawton SBR, Fekete EM, Brozoski DT, Wackman KK, Burnett CML, Nakagawa P, Sigmund CD, Segar JL, Grobe JL) Hypertension 2023 Sep;80(9):1871-1880 PMID: 37470185 PMCID: PMC10528934 SCOPUS ID: 2-s2.0-85168254483 07/20/2023    
  • Insights Into the Role of Angiotensin-II AT1 Receptor-Dependent β-Arrestin Signaling in Cardiovascular Disease. (Mathieu NM, Nakagawa P, Grobe JL, Sigmund CD) Hypertension 2024 Jan;81(1):6-16 PMID: 37449411 PMCID: PMC10787814 SCOPUS ID: 2-s2.0-85180800778 07/14/2023    
  • Cell-specific transcriptome changes in the hypothalamic arcuate nucleus in a mouse deoxycorticosterone acetate-salt model of hypertension. (Wagner VA, Deng G, Claflin KE, Ritter ML, Cui H, Nakagawa P, Sigmund CD, Morselli LL, Grobe JL, Kwitek AE) Front Cell Neurosci 2023;17:1207350 PMID: 37293629 PMCID: PMC10244568 SCOPUS ID: 2-s2.0-85161193387 06/09/2023       1 Citation
  • Genetic background in the rat affects endocrine and metabolic outcomes of bisphenol F exposure. (Wagner VA, Holl KL, Clark KC, Reho JJ, Dwinell MR, Lehmler HJ, Raff H, Grobe JL, Kwitek AE) Toxicol Sci 2023 Jun 28;194(1):84-100 PMID: 37191987 PMCID: PMC10306406 SCOPUS ID: 2-s2.0-85164065947 05/16/2023       1 Citation
  • Appraising the Preclinical Evidence of the Role of the Renin-Angiotensin-Aldosterone System in Antenatal Programming of Maternal and Offspring Cardiovascular Health Across the Life Course: Moving the Field Forward: A Scientific Statement From the American Heart Association. (Alexander BT, South AM, August P, Bertagnolli M, Ferranti EP, Grobe JL, Jones EJ, Loria AS, Safdar B, Sequeira-Lopez MLS, American Heart Association Council on the Kidney in Cardiovascular Disease; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; Council on Hypertension; and Council on Lifestyle and Cardiometabolic Health) Hypertension 2023 May;80(5):e75-e89 PMID: 36951054 PMCID: PMC10242542 SCOPUS ID: 2-s2.0-85153710110 03/24/2023       7 Citations
  • Cardiovascular Neuroendocrinology of Pregnancy (Opichka MA, Livergood MC, Grobe JL, McIntosh JJ) Masterclass in Neuroendocrinology 2023;14:111-135 SCOPUS ID: 2-s2.0-85178895537 01/01/2023    
  • CNS Regulation of Energy Balance (Grobe JL, Potthoff MJ) Handbook of Obesity - Volume 1: Epidemiology, Etiology, and Physiopathology, Fourth Edition 1 January 2023;1:207-215 SCOPUS ID: 2-s2.0-85179188970 01/01/2023    
  • Elucidating the role of Rgs2 expression in the PVN for metabolic homeostasis in mice. (Deng Y, Dickey JE, Saito K, Deng G, Singh U, Jiang J, Toth BA, Zhu Z, Zingman LV, Resch JM, Grobe JL, Cui H) Mol Metab 2022 Dec;66:101622 PMID: 36307046 PMCID: PMC9638802 SCOPUS ID: 2-s2.0-85141285048 10/29/2022       6 Citations
  • Cardiometabolic Consequences of Deleting the Regulator of G protein Signaling-2 (Rgs2) From Cells Expressing Agouti-Related Peptide or the ANG (Angiotensin) II Type 1A Receptor in Mice. (Ritter ML, Deng G, Reho JJ, Deng Y, Sapouckey SA, Opichka MA, Balapattabi K, Wackman KK, Brozoski DT, Lu KT, Paradee WJ, Gibson-Corley KN, Cui H, Nakagawa P, Morselli LL, Sigmund CD, Grobe JL) Hypertension 2022 Dec;79(12):2843-2853 PMID: 36259376 PMCID: PMC9649888 SCOPUS ID: 2-s2.0-85141891708 10/20/2022       1 Citation
  • ARRB2 (β-Arrestin-2) Deficiency Alters Fluid Homeostasis and Blood Pressure Regulation. (Mathieu NM, Nakagawa P, Grobe CC, Reho JJ, Brozoski DT, Lu KT, Wackman KK, Ritter ML, Segar JL, Grobe JL, Sigmund CD) Hypertension 2022 Nov;79(11):2480-2492 PMID: 36215165 PMCID: PMC9669141 SCOPUS ID: 2-s2.0-85140375825 10/11/2022       4 Citations
  • Patch-to-Seq and Transcriptomic Analyses Yield Molecular Markers of Functionally Distinct Brainstem Serotonin Neurons. (Mouradian GC Jr, Liu P, Nakagawa P, Duffy E, Gomez Vargas J, Balapattabi K, Grobe JL, Sigmund CD, Hodges MR) Front Synaptic Neurosci 2022;14:910820 PMID: 35844900 PMCID: PMC9280690 SCOPUS ID: 2-s2.0-85134237459 07/19/2022       2 Citations
  • Body Composition and Metabolic Changes in a Lyon Hypertensive Congenic Rat and Identification of Ercc6l2 as a Positional Candidate Gene. (Clark KC, Wagner VA, Holl KL, Reho JJ, Tutaj M, Smith JR, Dwinell MR, Grobe JL, Kwitek AE) Front Genet 2022;13:903971 PMID: 35812759 PMCID: PMC9263446 SCOPUS ID: 2-s2.0-85134024483 07/12/2022       1 Citation
  • Chronic intracerebroventricular infusion of angiotensin II causes dose- and sex-dependent effects on intake behaviors and energy homeostasis in C57BL/6J mice. (Oliveira V, Reho JJ, Balapattabi K, Ritter ML, Mathieu NM, Opichka MA, Lu KT, Grobe CC, Silva SD Jr, Wackman KK, Nakagawa P, Segar JL, Sigmund CD, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2022 Oct 01;323(4):R410-R421 PMID: 35816717 PMCID: PMC9512112 SCOPUS ID: 2-s2.0-85138457982 07/12/2022       4 Citations
  • Endothelial Cullin3 Mutation Impairs Nitric Oxide-Mediated Vasodilation and Promotes Salt-Induced Hypertension. (Wu J, Fang S, Lu KT, Kumar G, Reho JJ, Brozoski DT, Otanwa AJ, Hu C, Nair AR, Wackman KK, Agbor LN, Grobe JL, Sigmund CD) Function (Oxf) 2022;3(3):zqac017 PMID: 35493997 PMCID: PMC9045850 SCOPUS ID: 2-s2.0-85140270572 05/03/2022       6 Citations
  • Melanocortin MC4R receptor is required for energy expenditure but not blood pressure effects of angiotensin II within the mouse brain. (Oliveira V, Riedl RA, Claflin KE, Mathieu NM, Ritter ML, Balapattabi K, Wackman KK, Reho JJ, Brozoski DT, Morgan DA, Cui H, Rahmouni K, Burnett CML, Nakagawa P, Sigmund CD, Morselli LL, Grobe JL) Physiol Genomics 2022 Jun 01;54(6):196-205 PMID: 35476598 PMCID: PMC9131927 SCOPUS ID: 2-s2.0-85131018208 04/28/2022       2 Citations
  • Cardiometabolic effects of DOCA-salt in male C57BL/6J mice are variably dependent on sodium and nonsodium components of diet. (Patil CN, Ritter ML, Wackman KK, Oliveira V, Balapattabi K, Grobe CC, Brozoski DT, Reho JJ, Nakagawa P, Mouradian GC Jr, Kriegel AJ, Kwitek AE, Hodges MR, Segar JL, Sigmund CD, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2022 Jun 01;322(6):R467-R485 PMID: 35348007 PMCID: PMC9054347 SCOPUS ID: 2-s2.0-85129779185 03/30/2022       6 Citations
  • Methods for the Comprehensive in vivo Analysis of Energy Flux, Fluid Homeostasis, Blood Pressure, and Ventilatory Function in Rodents. (Reho JJ, Nakagawa P, Mouradian GC Jr, Grobe CC, Saravia FL, Burnett CML, Kwitek AE, Kirby JR, Segar JL, Hodges MR, Sigmund CD, Grobe JL) Front Physiol 2022;13:855054 PMID: 35283781 PMCID: PMC8914175 SCOPUS ID: 2-s2.0-85126220642 03/15/2022       13 Citations
  • Nicotinamide Riboside-Conditioned Microbiota Deflects High-Fat Diet-Induced Weight Gain in Mice. (Lozada-Fernández VV, deLeon O, Kellogg SL, Saravia FL, Hadiono MA, Atkinson SN, Grobe JL, Kirby JR) mSystems 2022 Feb 22;7(1):e0023021 PMID: 35076278 PMCID: PMC8788325 SCOPUS ID: 2-s2.0-85123715407 01/26/2022       11 Citations
  • NSAID-Induced Enteropathy Affects Regulation of Hepatic Glucose Production by Decreasing GLP-1 Secretion. (Herz H, Song Y, Ye Y, Tian L, Linden B, Abu El Haija M, Chu Y, Grobe JL, Lengeling RW, Mokadem M) Nutrients 2021 Dec 28;14(1) PMID: 35010994 PMCID: PMC8746549 SCOPUS ID: 2-s2.0-85121702542 01/12/2022       3 Citations
  • Short-term Housing in Metabolic Caging on Measures of Energy and Fluid Balance in Male C57BL/6J Mice ( Mus musculus). (Ziegler AA, Grobe CC, Reho JJ, Jensen ES, Thulin JD, Segar JL, Grobe JL) J Am Assoc Lab Anim Sci 2022 Mar 01;61(2):132-139 PMID: 34996529 PMCID: PMC8956215 SCOPUS ID: 2-s2.0-85126266838 01/09/2022       7 Citations
  • Nsaid-induced enteropathy affects regulation of hepatic glucose production by decreasing glp-1 secretion (Herz H, Song Y, Ye Y, Tian L, Linden B, El Haija MA, Chu Y, Grobe JL, Lengeling RW, Mokadem M) Nutrients January-1 2022;14(1) SCOPUS ID: 2-s2.0-85121702542 01/01/2022       3 Citations
  • Vascular Dysfunction in Preeclampsia. (Opichka MA, Rappelt MW, Gutterman DD, Grobe JL, McIntosh JJ) Cells 2021 Nov 06;10(11) PMID: 34831277 PMCID: PMC8616535 SCOPUS ID: 2-s2.0-85118544786 11/28/2021       82 Citations
  • Review vascular dysfunction in preeclampsia (Opichka MA, Rappelt MW, Gutterman DD, Grobe JL, McIntosh JJ) Cells November 2021;10(11) SCOPUS ID: 2-s2.0-85118544786 11/01/2021       82 Citations
  • Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI-Mediated High-Density Lipoprotein Uptake. (Xu H, Thomas MJ, Kaul S, Kallinger R, Ouweneel AB, Maruko E, Oussaada SM, Jongejan A, Cense HA, Nieuwdorp M, Serlie MJ, Goldberg IJ, Civelek M, Parks BW, Lusis AJ, Knaack D, Schill RL, May SC, Reho JJ, Grobe JL, Gantner B, Sahoo D, Sorci-Thomas MG) Arterioscler Thromb Vasc Biol 2021 Nov;41(11):2708-2725 PMID: 34551590 PMCID: PMC8551036 SCOPUS ID: 2-s2.0-85118592107 09/24/2021       6 Citations
  • Studies of salt and stress sensitivity on arterial pressure in renin-b deficient mice. (Nakagawa P, Gomez J, Lu KT, Grobe JL, Sigmund CD) PLoS One 2021;16(7):e0250807 PMID: 34319999 PMCID: PMC8318244 SCOPUS ID: 2-s2.0-85111564742 07/29/2021       2 Citations
  • Hypothalamic GPCR Signaling Pathways in Cardiometabolic Control. (Deng Y, Deng G, Grobe JL, Cui H) Front Physiol 2021;12:691226 PMID: 34262481 PMCID: PMC8274634 SCOPUS ID: 2-s2.0-85110342775 07/16/2021       2 Citations
  • Activation of the Central Renin-Angiotensin System Causes Local Cerebrovascular Dysfunction. (De Silva TM, Modrick ML, Grobe JL, Faraci FM) Stroke 2021 Jul;52(7):2404-2413 PMID: 34107734 PMCID: PMC8262118 SCOPUS ID: 2-s2.0-85111789053 06/11/2021       8 Citations
  • Maturational changes in sodium metabolism in periviable infants. (Segar JL, Grobe CC, Grobe JL) Pediatr Nephrol 2021 Nov;36(11):3693-3698 PMID: 34013388 PMCID: PMC8815317 SCOPUS ID: 2-s2.0-85106237462 05/21/2021       7 Citations
  • Team Science: American Heart Association's Hypertension Strategically Focused Research Network Experience. (Santillan MK, Becker RC, Calhoun DA, Cowley AW, Flynn JT, Grobe JL, Kotchen TA, Lackland DT, Leslie KK, Liang M, Mattson DL, Meyers KE, Mitsnefes MM, Muntner PM, Pierce GL, Pollock JS, Sigmund CD, Thomas SJ, Urbina EM, Kidambi S) Hypertension 2021 Jun;77(6):1857-1866 PMID: 33934625 PMCID: PMC8986150 SCOPUS ID: 2-s2.0-85105820455 05/04/2021       1 Citation
  • Gut Microbiota Represent a Major Thermogenic Biomass. (Riedl RA, Burnett CML, Pearson NA, Reho JJ, Mokadem M, Edwards RA, Kindel TL, Kirby JR, Grobe JL) Function (Oxf) 2021;2(3):zqab019 PMID: 33939772 PMCID: PMC8055641 SCOPUS ID: 2-s2.0-85114762228 05/04/2021       18 Citations
  • Bisphenol F Exposure in Adolescent Heterogeneous Stock Rats Affects Growth and Adiposity. (Wagner VA, Clark KC, Carrillo-Sáenz L, Holl KA, Velez-Bermudez M, Simonsen D, Grobe JL, Wang K, Thurman A, Solberg Woods LC, Lehmler HJ, Kwitek AE) Toxicol Sci 2021 May 27;181(2):246-261 PMID: 33755180 PMCID: PMC8163043 SCOPUS ID: 2-s2.0-85107319418 03/24/2021       7 Citations
  • BBSome ablation in SF1 neurons causes obesity without comorbidities. (Rouabhi M, Guo DF, Morgan DA, Zhu Z, López M, Zingman L, Grobe JL, Rahmouni K) Mol Metab 2021 Jun;48:101211 PMID: 33722691 PMCID: PMC8065214 SCOPUS ID: 2-s2.0-85104089262 03/17/2021       14 Citations
  • EP3 (E-Prostanoid 3) Receptor Mediates Impaired Vasodilation in a Mouse Model of Salt-Sensitive Hypertension. (Wu J, Fang S, Lu KT, Wackman K, Schwartzman ML, Dikalov SI, Grobe JL, Sigmund CD) Hypertension 2021 Apr;77(4):1399-1411 PMID: 33641369 PMCID: PMC7946772 SCOPUS ID: 2-s2.0-85102907974 03/02/2021       12 Citations
  • Recent Advances in Hypertension: Intersection of Metabolic and Blood Pressure Regulatory Circuits in the Central Nervous System. (Oliveira V, Kwitek AE, Sigmund CD, Morselli LL, Grobe JL) Hypertension 2021 Apr;77(4):1061-1068 PMID: 33611936 PMCID: PMC7990288 SCOPUS ID: 2-s2.0-85102906743 02/23/2021       17 Citations
  • Altered offspring neurodevelopment in an arginine vasopressin preeclampsia model. (Gumusoglu SB, Chilukuri ASS, Hing BWQ, Scroggins SM, Kundu S, Sandgren JA, Santillan MK, Santillan DA, Grobe JL, Stevens HE) Transl Psychiatry 2021 Jan 28;11(1):79 PMID: 33510137 PMCID: PMC7844013 SCOPUS ID: 2-s2.0-85100026156 01/30/2021       14 Citations
  • Dissociable effects of dietary sodium in early life upon somatic growth, fluid homeostasis, and spatial memory in mice of both sexes. (Segar JL, Grobe CC, Balapattabi K, Ritter ML, Reho JJ, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2021 Apr 01;320(4):R438-R451 PMID: 33439766 PMCID: PMC8238146 SCOPUS ID: 2-s2.0-85103803949 01/14/2021       5 Citations
  • β-Arrestin-Biased Agonist Targeting the Brain AT1R (Angiotensin II Type 1 Receptor) Increases Aversion to Saline and Lowers Blood Pressure in Deoxycorticosterone Acetate-Salt Hypertension. (Zanaty M, Seara FAC, Nakagawa P, Deng G, Mathieu NM, Balapattabi K, Karnik SS, Grobe JL, Sigmund CD) Hypertension 2021 Feb;77(2):420-431 PMID: 33249862 PMCID: PMC7855825 SCOPUS ID: 2-s2.0-85100070274 12/01/2020       14 Citations
  • Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass. (Ye Y, Abu El Haija M, Morgan DA, Guo D, Song Y, Frank A, Tian L, Riedl RA, Burnett CML, Gao Z, Zhu Z, Shahi SK, Zarei K, Couvelard A, Poté N, Ribeiro-Parenti L, Bado A, Noureddine L, Bellizzi A, Kievit P, Mangalam AK, Zingman LV, Le Gall M, Grobe JL, Kaplan LM, Clegg D, Rahmouni K, Mokadem M) Cell Rep 2020 Oct 27;33(4):108270 PMID: 33113371 PMCID: PMC7660289 SCOPUS ID: 2-s2.0-85094561791 10/29/2020       28 Citations
  • Quantification of body fluid compartmentalization by combined time-domain nuclear magnetic resonance and bioimpedance spectroscopy. (Segar JL, Balapattabi K, Reho JJ, Grobe CC, Burnett CML, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2021 Jan 01;320(1):R44-R54 PMID: 33085913 PMCID: PMC7847054 SCOPUS ID: 2-s2.0-85099721279 10/22/2020       11 Citations
  • Beat-to-Beat Blood Pressure Variability in the First Trimester Is Associated With the Development of Preeclampsia in a Prospective Cohort: Relation With Aortic Stiffness. (Nuckols VR, Holwerda SW, Luehrs RE, DuBose LE, Stroud AK, Brandt D, Betz AM, Fiedorowicz JG, Scroggins SM, Santillan DA, Grobe JL, Sigmund CD, Santillan MK, Pierce GL) Hypertension 2020 Dec;76(6):1800-1807 PMID: 32951467 PMCID: PMC7706825 SCOPUS ID: 2-s2.0-85096142926 09/22/2020       10 Citations
  • Coupling of energy intake and energy expenditure across a temperature spectrum: impact of diet-induced obesity in mice. (Ono-Moore KD, Rutkowsky JM, Pearson NA, Williams DK, Grobe JL, Tolentino T, Lloyd KCK, Adams SH) Am J Physiol Endocrinol Metab 2020 Sep 01;319(3):E472-E484 PMID: 32691631 PMCID: PMC7509245 SCOPUS ID: 2-s2.0-85089821961 07/22/2020       5 Citations
  • Increased Susceptibility of Mice Lacking Renin-b to Angiotensin II-Induced Organ Damage. (Nakagawa P, Nair AR, Agbor LN, Gomez J, Wu J, Zhang SY, Lu KT, Morgan DA, Rahmouni K, Grobe JL, Sigmund CD) Hypertension 2020 Aug;76(2):468-477 PMID: 32507043 PMCID: PMC7347438 SCOPUS ID: 2-s2.0-85087872461 06/09/2020       8 Citations
  • Single-Nucleus RNA Sequencing of the Hypothalamic Arcuate Nucleus of C57BL/6J Mice After Prolonged Diet-Induced Obesity. (Deng G, Morselli LL, Wagner VA, Balapattabi K, Sapouckey SA, Knudtson KL, Rahmouni K, Cui H, Sigmund CD, Kwitek AE, Grobe JL) Hypertension 2020 Aug;76(2):589-597 PMID: 32507042 PMCID: PMC7347451 SCOPUS ID: 2-s2.0-85087901067 06/09/2020       20 Citations
  • Failure to vasodilate in response to salt loading blunts renal blood flow and causes salt-sensitive hypertension. (Wu J, Agbor LN, Fang S, Mukohda M, Nair AR, Nakagawa P, Sharma A, Morgan DA, Grobe JL, Rahmouni K, Weiss RM, McCormick JA, Sigmund CD) Cardiovasc Res 2021 Jan 01;117(1):308-319 PMID: 32428209 PMCID: PMC7797211 SCOPUS ID: 2-s2.0-85097807979 05/20/2020       19 Citations
  • Feeding Formula Eliminates the Necessity of Bacterial Dysbiosis and Induces Inflammation and Injury in the Paneth Cell Disruption Murine NEC Model in an Osmolality-Dependent Manner. (Lueschow SR, Kern SL, Gong H, Grobe JL, Segar JL, Carlson SJ, McElroy SJ) Nutrients 2020 Mar 26;12(4) PMID: 32224880 PMCID: PMC7230818 SCOPUS ID: 2-s2.0-85082571970 04/01/2020       10 Citations
  • Exploration of cardiometabolic and developmental significance of angiotensinogen expression by cells expressing the leptin receptor or agouti-related peptide. (Sapouckey SA, Morselli LL, Deng G, Patil CN, Balapattabi K, Oliveira V, Claflin KE, Gomez J, Pearson NA, Potthoff MJ, Gibson-Corley KN, Sigmund CD, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2020 May 01;318(5):R855-R869 PMID: 32186897 PMCID: PMC7272763 SCOPUS ID: 2-s2.0-85083546405 03/19/2020       8 Citations
  • A colorful view of the brain renin-angiotensin system. (Sigmund CD, Grobe JL) Hypertens Res 2020 Apr;43(4):357-359 PMID: 31953528 PMCID: PMC7107486 SCOPUS ID: 2-s2.0-85078310812 01/19/2020       6 Citations
  • Fetal storage of osmotically inactive sodium. (Segar JL, Grobe CC, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2020 Mar 01;318(3):R512-R514 PMID: 31940233 PMCID: PMC7099460 SCOPUS ID: 2-s2.0-85080850805 01/16/2020       4 Citations
  • The Renin-Angiotensin System in the Central Nervous System and Its Role in Blood Pressure Regulation. (Nakagawa P, Gomez J, Grobe JL, Sigmund CD) Curr Hypertens Rep 2020 Jan 10;22(1):7 PMID: 31925571 PMCID: PMC7101821 SCOPUS ID: 2-s2.0-85077710193 01/12/2020       56 Citations
  • Reduced mRNA Expression of RGS2 (Regulator of G Protein Signaling-2) in the Placenta Is Associated With Human Preeclampsia and Sufficient to Cause Features of the Disorder in Mice. (Perschbacher KJ, Deng G, Sandgren JA, Walsh JW, Witcher PC, Sapouckey SA, Owens CE, Zhang SY, Scroggins SM, Pearson NA, Devor EJ, Sebag JA, Pierce GL, Fisher RA, Kwitek AE, Santillan DA, Gibson-Corley KN, Sigmund CD, Santillan MK, Grobe JL) Hypertension 2020 Feb;75(2):569-579 PMID: 31865781 PMCID: PMC7027931 SCOPUS ID: 2-s2.0-85077761676 12/24/2019       21 Citations
  • The BBSome in POMC and AgRP Neurons Is Necessary for Body Weight Regulation and Sorting of Metabolic Receptors. (Guo DF, Lin Z, Wu Y, Searby C, Thedens DR, Richerson GB, Usachev YM, Grobe JL, Sheffield VC, Rahmouni K) Diabetes 2019 Aug;68(8):1591-1603 PMID: 31127052 PMCID: PMC6692817 SCOPUS ID: 2-s2.0-85070184998 05/28/2019       33 Citations
  • Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Protects From Angiotensin II-Induced Endothelial Dysfunction in Adult Offspring Born From Pregnancies Complicated by Hypertension. (Nair AR, Silva SD Jr, Agbor LN, Wu J, Nakagawa P, Mukohda M, Lu KT, Sandgren JA, Pierce GL, Santillan MK, Grobe JL, Sigmund CD) Hypertension 2019 Jul;74(1):173-183 PMID: 31104564 PMCID: PMC6561821 SCOPUS ID: 2-s2.0-85068196613 05/21/2019       19 Citations
  • Comparison of the Effects of High-Fat Diet on Energy Flux in Mice Using Two Multiplexed Metabolic Phenotyping Systems. (Soto JE, Burnett CML, Ten Eyck P, Abel ED, Grobe JL) Obesity (Silver Spring) 2019 May;27(5):793-802 PMID: 30938081 PMCID: PMC6478533 SCOPUS ID: 2-s2.0-85063691148 04/03/2019       22 Citations
  • Celastrol Reduces Obesity in MC4R Deficiency and Stimulates Sympathetic Nerve Activity Affecting Metabolic and Cardiovascular Functions. (Saito K, Davis KC, Morgan DA, Toth BA, Jiang J, Singh U, Berglund ED, Grobe JL, Rahmouni K, Cui H) Diabetes 2019 Jun;68(6):1210-1220 PMID: 30894367 PMCID: PMC6610022 SCOPUS ID: 2-s2.0-85066428424 03/22/2019       30 Citations
  • Liver Derived FGF21 Maintains Core Body Temperature During Acute Cold Exposure. (Ameka M, Markan KR, Morgan DA, BonDurant LD, Idiga SO, Naber MC, Zhu Z, Zingman LV, Grobe JL, Rahmouni K, Potthoff MJ) Sci Rep 2019 Jan 24;9(1):630 PMID: 30679672 PMCID: PMC6345819 SCOPUS ID: 2-s2.0-85060548991 01/27/2019       64 Citations
  • The renin-angiotensin system in the arcuate nucleus controls resting metabolic rate. (Deng G, Grobe JL) Curr Opin Nephrol Hypertens 2019 Mar;28(2):120-127 PMID: 30531199 PMCID: PMC6366639 SCOPUS ID: 2-s2.0-85060647576 12/12/2018       13 Citations
  • Arginine vasopressin infusion is sufficient to model clinical features of preeclampsia in mice. (Sandgren JA, Deng G, Linggonegoro DW, Scroggins SM, Perschbacher KJ, Nair AR, Nishimura TE, Zhang SY, Agbor LN, Wu J, Keen HL, Naber MC, Pearson NA, Zimmerman KA, Weiss RM, Bowdler NC, Usachev YM, Santillan DA, Potthoff MJ, Pierce GL, Gibson-Corley KN, Sigmund CD, Santillan MK, Grobe JL) JCI Insight 2018 Oct 04;3(19) PMID: 30282823 PMCID: PMC6237463 SCOPUS ID: 2-s2.0-85063243804 10/05/2018       56 Citations
  • Regulators of G protein signaling in cardiovascular function during pregnancy. (Perschbacher KJ, Deng G, Fisher RA, Gibson-Corley KN, Santillan MK, Grobe JL) Physiol Genomics 2018 Aug 01;50(8):590-604 PMID: 29702036 PMCID: PMC6139632 SCOPUS ID: 2-s2.0-85056621405 04/28/2018       26 Citations
  • Control of Energy Expenditure by AgRP Neurons of the Arcuate Nucleus: Neurocircuitry, Signaling Pathways, and Angiotensin. (Morselli LL, Claflin KE, Cui H, Grobe JL) Curr Hypertens Rep 2018 Mar 19;20(3):25 PMID: 29556733 PMCID: PMC5882211 SCOPUS ID: 2-s2.0-85044249515 03/21/2018       26 Citations
  • Elevated vasopressin in pregnant mice induces T-helper subset alterations consistent with human preeclampsia. (Scroggins SM, Santillan DA, Lund JM, Sandgren JA, Krotz LK, Hamilton WS, Devor EJ, Davis HA, Pierce GL, Gibson-Corley KN, Sigmund CD, Grobe JL, Santillan MK) Clin Sci (Lond) 2018 Feb 14;132(3):419-436 PMID: 29371289 PMCID: PMC5947858 SCOPUS ID: 2-s2.0-85046542605 01/27/2018       37 Citations
  • Angiotensin AT1A receptors expressed in vasopressin-producing cells of the supraoptic nucleus contribute to osmotic control of vasopressin. (Sandgren JA, Linggonegoro DW, Zhang SY, Sapouckey SA, Claflin KE, Pearson NA, Leidinger MR, Pierce GL, Santillan MK, Gibson-Corley KN, Sigmund CD, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2018 Jun 01;314(6):R770-R780 PMID: 29364700 PMCID: PMC6032302 SCOPUS ID: 2-s2.0-85048097812 01/25/2018       30 Citations
  • Potential mechanisms of hypothalamic renin-angiotensin system activation by leptin and DOCA-salt for the control of resting metabolism. (Sapouckey SA, Deng G, Sigmund CD, Grobe JL) Physiol Genomics 2017 Dec 01;49(12):722-732 PMID: 28986397 PMCID: PMC5814669 SCOPUS ID: 2-s2.0-85044192981 10/08/2017       18 Citations
  • MRAP2 regulates ghrelin receptor signaling and hunger sensing. (Srisai D, Yin TC, Lee AA, Rouault AAJ, Pearson NA, Grobe JL, Sebag JA) Nat Commun 2017 Sep 28;8(1):713 PMID: 28959025 PMCID: PMC5620068 SCOPUS ID: 2-s2.0-85030105001 09/30/2017       52 Citations
  • Selective Deletion of Renin-b in the Brain Alters Drinking and Metabolism. (Shinohara K, Nakagawa P, Gomez J, Morgan DA, Littlejohn NK, Folchert MD, Weidemann BJ, Liu X, Walsh SA, Ponto LL, Rahmouni K, Grobe JL, Sigmund CD) Hypertension 2017 Nov;70(5):990-997 PMID: 28874461 PMCID: PMC5679092 SCOPUS ID: 2-s2.0-85031820971 09/07/2017       16 Citations
  • Comprehensive Assessments of Energy Balance in Mice. (Grobe JL) Methods Mol Biol 2017;1614:123-146 PMID: 28500600 PMCID: PMC5582947 SCOPUS ID: 2-s2.0-85019176097 05/14/2017       32 Citations
  • Evidence for intraventricular secretion of angiotensinogen and angiotensin by the subfornical organ using transgenic mice. (Agassandian K, Grobe JL, Liu X, Agassandian M, Thompson AP, Sigmund CD, Cassell MD) Am J Physiol Regul Integr Comp Physiol 2017 Jun 01;312(6):R973-R981 PMID: 28490451 PMCID: PMC5495920 SCOPUS ID: 2-s2.0-85020436522 05/12/2017       10 Citations
  • The Gut Microbiome, Energy Homeostasis, and Implications for Hypertension. (Riedl RA, Atkinson SN, Burnett CML, Grobe JL, Kirby JR) Curr Hypertens Rep 2017 Apr;19(4):27 PMID: 28316052 PMCID: PMC5773096 SCOPUS ID: 2-s2.0-85015782153 03/21/2017       41 Citations
  • Angiotensin AT1A receptors on leptin receptor-expressing cells control resting metabolism. (Claflin KE, Sandgren JA, Lambertz AM, Weidemann BJ, Littlejohn NK, Burnett CM, Pearson NA, Morgan DA, Gibson-Corley KN, Rahmouni K, Grobe JL) J Clin Invest 2017 Apr 03;127(4):1414-1424 PMID: 28263184 PMCID: PMC5373887 SCOPUS ID: 2-s2.0-85018718095 03/07/2017       57 Citations
  • Selective Deletion of the Brain-Specific Isoform of Renin Causes Neurogenic Hypertension. (Shinohara K, Liu X, Morgan DA, Davis DR, Sequeira-Lopez ML, Cassell MD, Grobe JL, Rahmouni K, Sigmund CD) Hypertension 2016 Dec;68(6):1385-1392 PMID: 27754863 PMCID: PMC5159235 SCOPUS ID: 2-s2.0-84991696091 10/19/2016       42 Citations
  • Obesity alters immune and metabolic profiles: New insight from obese-resistant mice on high-fat diet. (Boi SK, Buchta CM, Pearson NA, Francis MB, Meyerholz DK, Grobe JL, Norian LA) Obesity (Silver Spring) 2016 Oct;24(10):2140-9 PMID: 27515998 PMCID: PMC5039085 SCOPUS ID: 2-s2.0-84988699941 08/16/2016       51 Citations
  • Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. (Littlejohn NK, Keen HL, Weidemann BJ, Claflin KE, Tobin KV, Markan KR, Park S, Naber MC, Gourronc FA, Pearson NA, Liu X, Morgan DA, Klingelhutz AJ, Potthoff MJ, Rahmouni K, Sigmund CD, Grobe JL) Cell Rep 2016 Aug 09;16(6):1548-1560 PMID: 27477281 PMCID: PMC4981564 SCOPUS ID: 2-s2.0-84979752805 08/02/2016       36 Citations
  • mTORC1 Signaling Contributes to Drinking But Not Blood Pressure Responses to Brain Angiotensin II. (Muta K, Morgan DA, Grobe JL, Sigmund CD, Rahmouni K) Endocrinology 2016 Aug;157(8):3140-8 PMID: 27254006 PMCID: PMC4967111 SCOPUS ID: 2-s2.0-84982797786 06/03/2016       9 Citations
  • Breaking a Mother's Heart: Circulating Antiangiogenic Factors and Hypertension During Pregnancy Correlate With Specific Cardiac Dysfunctions. (Sandgren JA, Santillan MK, Grobe JL) Hypertension 2016 Jun;67(6):1119-20 PMID: 27113050 PMCID: PMC4865412 SCOPUS ID: 2-s2.0-84966565032 04/27/2016       4 Citations
  • The BBSome Controls Energy Homeostasis by Mediating the Transport of the Leptin Receptor to the Plasma Membrane. (Guo DF, Cui H, Zhang Q, Morgan DA, Thedens DR, Nishimura D, Grobe JL, Sheffield VC, Rahmouni K) PLoS Genet 2016 Feb;12(2):e1005890 PMID: 26926121 PMCID: PMC4771807 SCOPUS ID: 2-s2.0-84959876003 03/02/2016       89 Citations
  • Introduction to the American Heart Association's Hypertension Strategically Focused Research Network. (Muntner P, Becker RC, Calhoun D, Chen D, Cowley AW Jr, Flynn JT, Grobe JL, Kidambi S, Kotchen TA, Lackland DT, Leslie KK, Li Y, Liang M, Lloyd A, Mattson DL, Mendizabal B, Mitsnefes M, Nair A, Pierce GL, Pollock JS, Safford MM, Santillan MK, Sigmund CD, Thomas SJ, Urbina EM) Hypertension 2016 Apr;67(4):674-80 PMID: 26902490 PMCID: PMC5135412 SCOPUS ID: 2-s2.0-84960812805 02/24/2016       7 Citations
  • Risperidone-induced weight gain is mediated through shifts in the gut microbiome and suppression of energy expenditure. (Bahr SM, Weidemann BJ, Castro AN, Walsh JW, deLeon O, Burnett CM, Pearson NA, Murry DJ, Grobe JL, Kirby JR) EBioMedicine 2015 Nov;2(11):1725-34 PMID: 26870798 PMCID: PMC4740326 SCOPUS ID: 2-s2.0-84958879311 02/13/2016       105 Citations
  • Heat acclimation and thirst in rats. (Barney CC, Schanhals EM, Grobe JL, Andresen BT, Traver M) Physiol Rep 2015 Dec;3(12) PMID: 26702076 PMCID: PMC4760436 SCOPUS ID: 2-s2.0-85006001667 12/25/2015       5 Citations
  • Protective Role for Tissue Inhibitor of Metalloproteinase-4, a Novel Peroxisome Proliferator-Activated Receptor-γ Target Gene, in Smooth Muscle in Deoxycorticosterone Acetate-Salt Hypertension. (Ketsawatsomkron P, Keen HL, Davis DR, Lu KT, Stump M, De Silva TM, Hilzendeger AM, Grobe JL, Faraci FM, Sigmund CD) Hypertension 2016 Jan;67(1):214-22 PMID: 26597823 PMCID: PMC4679422 SCOPUS ID: 2-s2.0-84950335650 11/26/2015       22 Citations
  • Opposing tissue-specific roles of angiotensin in the pathogenesis of obesity, and implications for obesity-related hypertension. (Littlejohn NK, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2015 Dec 15;309(12):R1463-73 PMID: 26491099 PMCID: PMC4698411 SCOPUS ID: 2-s2.0-84983143153 10/23/2015       26 Citations
  • Dietary Sodium Suppresses Digestive Efficiency via the Renin-Angiotensin System. (Weidemann BJ, Voong S, Morales-Santiago FI, Kahn MZ, Ni J, Littlejohn NK, Claflin KE, Burnett CM, Pearson NA, Lutter ML, Grobe JL) Sci Rep 2015 Jun 11;5:11123 PMID: 26068176 PMCID: PMC4464075 SCOPUS ID: 2-s2.0-84931281934 06/13/2015       25 Citations
  • Brain endoplasmic reticulum stress mechanistically distinguishes the saline-intake and hypertensive response to deoxycorticosterone acetate-salt. (Jo F, Jo H, Hilzendeger AM, Thompson AP, Cassell MD, Rutkowski DT, Davisson RL, Grobe JL, Sigmund CD) Hypertension 2015 Jun;65(6):1341-8 PMID: 25895586 PMCID: PMC4433403 SCOPUS ID: 2-s2.0-84937622096 04/22/2015       17 Citations
  • Control of energy balance by the brain renin-angiotensin system. (Claflin KE, Grobe JL) Curr Hypertens Rep 2015 May;17(5):38 PMID: 25833461 SCOPUS ID: 2-s2.0-84926395585 04/04/2015       27 Citations
  • Vasopressin: the missing link for preeclampsia? (Sandgren JA, Scroggins SM, Santillan DA, Devor EJ, Gibson-Corley KN, Pierce GL, Sigmund CD, Santillan MK, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2015 Nov 01;309(9):R1062-4 PMID: 25810383 PMCID: PMC4666952 SCOPUS ID: 2-s2.0-84946088245 03/27/2015       38 Citations
  • Erratum: Vasopressin in preeclampsia: A novel very early human pregnancy biomarker and clinically relevant mouse model (Hypertension (2014) 64 (852-859)) (Santillan MK, Santillan DA, Scroggins SM, Min JY, Sandgren JA, Pearson NA, Leslie KK, Hunter SK, Zamba GKD, Gibson-Corley KN, Grobe JL) Hypertension 4 March 2015;65(3):e9 SCOPUS ID: 2-s2.0-84924133802 03/04/2015    
  • Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes. (Santillan MK, Pelham CJ, Ketsawatsomkron P, Santillan DA, Davis DR, Devor EJ, Gibson-Corley KN, Scroggins SM, Grobe JL, Yang B, Hunter SK, Sigmund CD) Physiol Rep 2015 Jan 01;3(1) PMID: 25602015 PMCID: PMC4387753 SCOPUS ID: 2-s2.0-84992329274 01/21/2015       54 Citations
  • Mechanisms of brain renin angiotensin system-induced drinking and blood pressure: importance of the subfornical organ. (Coble JP, Grobe JL, Johnson AK, Sigmund CD) Am J Physiol Regul Integr Comp Physiol 2015 Feb 15;308(4):R238-49 PMID: 25519738 PMCID: PMC4347751 SCOPUS ID: 2-s2.0-84923163679 12/19/2014       71 Citations
  • Direct pro-inflammatory effects of prorenin on microglia. (Shi P, Grobe JL, Desland FA, Zhou G, Shen XZ, Shan Z, Liu M, Raizada MK, Sumners C) PLoS One 2014;9(10):e92937 PMID: 25302502 PMCID: PMC4193744 SCOPUS ID: 2-s2.0-84907833438 10/11/2014       70 Citations
  • A mitochondrial-targeted coenzyme q analog prevents weight gain and ameliorates hepatic dysfunction in high-fat-fed mice. (Fink BD, Herlein JA, Guo DF, Kulkarni C, Weidemann BJ, Yu L, Grobe JL, Rahmouni K, Kerns RJ, Sivitz WI) J Pharmacol Exp Ther 2014 Dec;351(3):699-708 PMID: 25301169 PMCID: PMC4244581 SCOPUS ID: 2-s2.0-84964698143 10/11/2014       35 Citations
  • Another reason to eat your greens: cardiopulmonary protection by dietary delivery of angiotensin-converting enzyme-2 and angiotensin-(1-7) made in plants. (Grobe JL, Sigmund CD) Hypertension 2014 Dec;64(6):1182-3 PMID: 25225201 SCOPUS ID: 2-s2.0-84927797099 09/17/2014       3 Citations
  • Role of vascular smooth muscle PPARγ in regulating AT1 receptor signaling and angiotensin II-dependent hypertension. (Carrillo-Sepulveda MA, Keen HL, Davis DR, Grobe JL, Sigmund CD) PLoS One 2014;9(8):e103786 PMID: 25122005 PMCID: PMC4133177 SCOPUS ID: 2-s2.0-84905989058 08/15/2014       11 Citations
  • Ablation of the GNB3 gene in mice does not affect body weight, metabolism or blood pressure, but causes bradycardia. (Ye Y, Sun Z, Guo A, Song LS, Grobe JL, Chen S) Cell Signal 2014 Nov;26(11):2514-20 PMID: 25093805 PMCID: PMC4160384 SCOPUS ID: 2-s2.0-84906069343 08/06/2014       14 Citations
  • Vasopressin in preeclampsia: a novel very early human pregnancy biomarker and clinically relevant mouse model. (Santillan MK, Santillan DA, Scroggins SM, Min JY, Sandgren JA, Pearson NA, Leslie KK, Hunter SK, Zamba GK, Gibson-Corley KN, Grobe JL) Hypertension 2014 Oct;64(4):852-9 PMID: 25001273 PMCID: PMC4162750 SCOPUS ID: 2-s2.0-84914688812 07/09/2014       108 Citations
  • Activation of the renin-angiotensin system, specifically in the subfornical organ is sufficient to induce fluid intake. (Coble JP, Cassell MD, Davis DR, Grobe JL, Sigmund CD) Am J Physiol Regul Integr Comp Physiol 2014 Aug 15;307(4):R376-86 PMID: 24965793 PMCID: PMC4137154 SCOPUS ID: 2-s2.0-84907637962 06/27/2014       20 Citations
  • Dietary effects on resting metabolic rate in C57BL/6 mice are differentially detected by indirect (O2/CO2 respirometry) and direct calorimetry. (Burnett CM, Grobe JL) Mol Metab 2014 Jul;3(4):460-4 PMID: 24944905 PMCID: PMC4060218 SCOPUS ID: 2-s2.0-84902303624 06/20/2014       34 Citations
  • Activity of protein kinase C-α within the subfornical organ is necessary for fluid intake in response to brain angiotensin. (Coble JP, Johnson RF, Cassell MD, Johnson AK, Grobe JL, Sigmund CD) Hypertension 2014 Jul;64(1):141-8 PMID: 24777977 PMCID: PMC4057298 SCOPUS ID: 2-s2.0-84902551083 04/30/2014       17 Citations
  • Neuron-specific (pro)renin receptor knockout prevents the development of salt-sensitive hypertension. (Li W, Peng H, Mehaffey EP, Kimball CD, Grobe JL, van Gool JM, Sullivan MN, Earley S, Danser AH, Ichihara A, Feng Y) Hypertension 2014 Feb;63(2):316-23 PMID: 24246383 PMCID: PMC3947277 SCOPUS ID: 2-s2.0-84892940481 11/20/2013       88 Citations
  • Direct calorimetry identifies deficiencies in respirometry for the determination of resting metabolic rate in C57Bl/6 and FVB mice. (Burnett CM, Grobe JL) Am J Physiol Endocrinol Metab 2013 Oct 01;305(7):E916-24 PMID: 23964071 PMCID: PMC3798702 SCOPUS ID: 2-s2.0-84884929609 08/22/2013       34 Citations
  • Hypertension in mice with transgenic activation of the brain renin-angiotensin system is vasopressin dependent. (Littlejohn NK, Siel RB Jr, Ketsawatsomkron P, Pelham CJ, Pearson NA, Hilzendeger AM, Buehrer BA, Weidemann BJ, Li H, Davis DR, Thompson AP, Liu X, Cassell MD, Sigmund CD, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2013 May 15;304(10):R818-28 PMID: 23535460 PMCID: PMC3652167 SCOPUS ID: 2-s2.0-84878651210 03/29/2013       56 Citations
  • Angiotensin type 1a receptors in the subfornical organ are required for deoxycorticosterone acetate-salt hypertension. (Hilzendeger AM, Cassell MD, Davis DR, Stauss HM, Mark AL, Grobe JL, Sigmund CD) Hypertension 2013 Mar;61(3):716-22 PMID: 23266541 PMCID: PMC3573251 SCOPUS ID: 2-s2.0-84874360680 12/26/2012       55 Citations
  • The adipose/circulating renin-angiotensin system cross-talk enters a new dimension. (Grobe JL, Rahmouni K) Hypertension 2012 Dec;60(6):1389-90 PMID: 23108659 PMCID: PMC3959780 SCOPUS ID: 2-s2.0-84870238888 10/31/2012       9 Citations
  • Cullin-3 regulates vascular smooth muscle function and arterial blood pressure via PPARγ and RhoA/Rho-kinase. (Pelham CJ, Ketsawatsomkron P, Groh S, Grobe JL, de Lange WJ, Ibeawuchi SR, Keen HL, Weatherford ET, Faraci FM, Sigmund CD) Cell Metab 2012 Oct 03;16(4):462-72 PMID: 23040068 PMCID: PMC3474846 SCOPUS ID: 2-s2.0-84867084491 10/09/2012       84 Citations
  • PPARγ regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity. (Ketsawatsomkron P, Lorca RA, Keen HL, Weatherford ET, Liu X, Pelham CJ, Grobe JL, Faraci FM, England SK, Sigmund CD) Circ Res 2012 Nov 09;111(11):1446-58 PMID: 22962432 PMCID: PMC3494760 SCOPUS ID: 2-s2.0-84870039725 09/11/2012       53 Citations
  • A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity. (Hilzendeger AM, Morgan DA, Brooks L, Dellsperger D, Liu X, Grobe JL, Rahmouni K, Sigmund CD, Mark AL) Am J Physiol Heart Circ Physiol 2012 Jul 15;303(2):H197-206 PMID: 22610169 PMCID: PMC3404702 SCOPUS ID: 2-s2.0-84864011880 05/23/2012       98 Citations
  • Metabolic rate regulation by the renin-angiotensin system: brain vs. body. (Grobe JL, Rahmouni K, Liu X, Sigmund CD) Pflugers Arch 2013 Jan;465(1):167-75 PMID: 22491893 PMCID: PMC3569511 SCOPUS ID: 2-s2.0-84873056337 04/12/2012       24 Citations
  • Editorial focus: A fat contribution to RAS activation and blood pressure control: evidence from angiotensinogen conditional null mice. Focus on: "Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice.". (Grobe JL, Rahmouni K) Am J Physiol Regul Integr Comp Physiol 2012 Jan 15;302(2):R242-3 PMID: 22071163 SCOPUS ID: 2-s2.0-84855312273 11/11/2011    
  • Renal proximal tubule angiotensin AT1A receptors regulate blood pressure. (Li H, Weatherford ET, Davis DR, Keen HL, Grobe JL, Daugherty A, Cassis LA, Allen AM, Sigmund CD) Am J Physiol Regul Integr Comp Physiol 2011 Oct;301(4):R1067-77 PMID: 21753145 PMCID: PMC3197336 SCOPUS ID: 2-s2.0-80053655134 07/15/2011       73 Citations
  • Angiotensinergic signaling in the brain mediates metabolic effects of deoxycorticosterone (DOCA)-salt in C57 mice. (Grobe JL, Buehrer BA, Hilzendeger AM, Liu X, Davis DR, Xu D, Sigmund CD) Hypertension 2011 Mar;57(3):600-7 PMID: 21263123 PMCID: PMC3144490 SCOPUS ID: 2-s2.0-79953191408 01/26/2011       78 Citations
  • Neuron- or glial-specific ablation of secreted renin does not affect renal renin, baseline arterial pressure, or metabolism. (Xu D, Borges GR, Davis DR, Agassandian K, Sequeira Lopez ML, Gomez RA, Cassell MD, Grobe JL, Sigmund CD) Physiol Genomics 2011 Mar 29;43(6):286-94 PMID: 21189370 PMCID: PMC3068515 SCOPUS ID: 2-s2.0-79955774465 12/30/2010       20 Citations
  • The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance. (Grobe JL, Grobe CL, Beltz TG, Westphal SG, Morgan DA, Xu D, de Lange WJ, Li H, Sakai K, Thedens DR, Cassis LA, Rahmouni K, Mark AL, Johnson AK, Sigmund CD) Cell Metab 2010 Nov 03;12(5):431-42 PMID: 21035755 PMCID: PMC2994017 SCOPUS ID: 2-s2.0-78049448391 11/03/2010       126 Citations
  • Cardiovascular consequences of genetic variation at -6/235 in human angiotensinogen using "humanized" gene-targeted mice. (Grobe JL, Dickson ME, Park S, Davis DR, Born EJ, Sigmund CD) Hypertension 2010 Nov;56(5):981-7 PMID: 20823378 PMCID: PMC2959143 SCOPUS ID: 2-s2.0-78149258856 09/09/2010       9 Citations
  • Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin. (Xu D, Borges GR, Grobe JL, Pelham CJ, Yang B, Sigmund CD) Hypertension 2009 Dec;54(6):1240-7 PMID: 19822797 PMCID: PMC2783841 SCOPUS ID: 2-s2.0-73349119699 10/14/2009       33 Citations
  • 17beta-Estradiol modulates local cardiac renin-angiotensin system to prevent cardiac remodeling in the DOCA-salt model of hypertension in rats. (Shenoy V, Grobe JL, Qi Y, Ferreira AJ, Fraga-Silva RA, Collamat G, Bruce E, Katovich MJ) Peptides 2009 Dec;30(12):2309-15 PMID: 19747516 SCOPUS ID: 2-s2.0-70449632336 09/15/2009       38 Citations
  • PPARgamma differentially regulates energy substrate handling in brown vs. white adipose: focus on "The PPARgamma agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake". (Grobe JL, Venegas-Pont M, Sigmund CD, Ryan MJ) Am J Physiol Regul Integr Comp Physiol 2009 May;296(5):R1325-6 PMID: 19261916 PMCID: PMC3597227 SCOPUS ID: 2-s2.0-66149112458 03/06/2009       5 Citations
  • Angiotensin-(1-7) as an antihypertensive, antifibrotic target. (Katovich MJ, Grobe JL, Raizada MK) Curr Hypertens Rep 2008 Jun;10(3):227-32 PMID: 18765095 SCOPUS ID: 2-s2.0-56349087447 09/04/2008       33 Citations
  • An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy. (Grobe JL, Xu D, Sigmund CD) Physiology (Bethesda) 2008 Aug;23:187-93 PMID: 18697992 PMCID: PMC2538674 SCOPUS ID: 2-s2.0-53749104976 08/14/2008       156 Citations
  • Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiology. (Der Sarkissian S, Grobe JL, Yuan L, Narielwala DR, Walter GA, Katovich MJ, Raizada MK) Hypertension 2008 Mar;51(3):712-8 PMID: 18250366 SCOPUS ID: 2-s2.0-39749202869 02/06/2008       129 Citations
  • ACE2 overexpression inhibits hypoxia-induced collagen production by cardiac fibroblasts. (Grobe JL, Der Sarkissian S, Stewart JM, Meszaros JG, Raizada MK, Katovich MJ) Clin Sci (Lond) 2007 Oct;113(8):357-64 PMID: 17600530 SCOPUS ID: 2-s2.0-34648826015 06/30/2007       76 Citations
  • Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7). (Grobe JL, Mecca AP, Lingis M, Shenoy V, Bolton TA, Machado JM, Speth RC, Raizada MK, Katovich MJ) Am J Physiol Heart Circ Physiol 2007 Feb;292(2):H736-42 PMID: 17098828 SCOPUS ID: 2-s2.0-33846987938 11/14/2006       308 Citations
  • Potentiation of the antihypertensive action of losartan by peripheral overexpression of the ANG II type 2 receptor. (Li H, Gao Y, Grobe JL, Raizada MK, Katovich MJ, Sumners C) Am J Physiol Heart Circ Physiol 2007 Feb;292(2):H727-35 PMID: 17085538 SCOPUS ID: 2-s2.0-33846977415 11/07/2006       27 Citations
  • Chronic angiotensin-(1-7) prevents cardiac fibrosis in DOCA-salt model of hypertension. (Grobe JL, Mecca AP, Mao H, Katovich MJ) Am J Physiol Heart Circ Physiol 2006 Jun;290(6):H2417-23 PMID: 16415071 SCOPUS ID: 2-s2.0-33744910056 01/18/2006       184 Citations
  • Alterations in aortic vascular reactivity to angiotensin 1-7 in 17-beta-estradiol-treated female SD rats. (Grobe JL, Katovich MJ) Regul Pept 2006 Jan 15;133(1-3):62-7 PMID: 16219374 SCOPUS ID: 2-s2.0-29244468892 10/13/2005       10 Citations
  • Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats. (Huentelman MJ, Grobe JL, Vazquez J, Stewart JM, Mecca AP, Katovich MJ, Ferrario CM, Raizada MK) Exp Physiol 2005 Sep;90(5):783-90 PMID: 16049057 SCOPUS ID: 2-s2.0-26044453206 07/29/2005       213 Citations
  • Angiotensin-converting enzyme 2 as a novel target for gene therapy for hypertension. (Katovich MJ, Grobe JL, Huentelman M, Raizada MK) Exp Physiol 2005 May;90(3):299-305 PMID: 15640278 SCOPUS ID: 2-s2.0-18844381161 01/11/2005       31 Citations
  • Role of angiotensin II and the subfornical organ in the pharmacological actions of ethanol. (Grobe J, Rowland N, Katovich M) Alcohol Alcohol 2004;39(5):410-7 PMID: 15289207 SCOPUS ID: 2-s2.0-4544303871 08/04/2004       6 Citations
  • Thermal dehydration-induced thirst in lithium-treated rats. (Barney CC, Kurylo DM, Grobe JL) Pharmacol Biochem Behav 2003 May;75(2):341-7 PMID: 12873625 SCOPUS ID: 2-s2.0-0038107686 07/23/2003       3 Citations
  • Expression of VACM-1 protein in cultured rat adrenal endothelial cells is linked to the cell cycle. (Burnatowska-Hledin, Zeneberg A, Roulo A, Grobe J, Zhao P, Lelkes PI, Clare P, Barney C) Endothelium 2001;8(1):49-63 PMID: 11409851 SCOPUS ID: 2-s2.0-0035013794 06/21/2001       17 Citations
    • Last update: 05/10/2024