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Justin L. Grobe PhD

Justin L. Grobe PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Physiology

Member of the Cardiovascular Center
Member of the Neuroscience Research Center

I am willing to mentor a junior faculty member.
I am willing to collaborate on research projects.

Research Experience

  • Arginine Vasopressin
  • Blood Pressure
  • Energy Metabolism
  • Gastrointestinal Microbiome
  • Hypertension
  • Hypothalamus
  • Obesity
  • Pre-Eclampsia
  • Pregnancy
  • Receptors, G-Protein-Coupled
  • Renin-Angiotensin System
  • Water-Electrolyte Balance
  • Methodologies and Techniques

  • Analysis of Variance
  • Basal Metabolism
  • Calorimetry
  • Dose-Response Relationship, Drug
  • Eating
  • Energy Metabolism
  • Feeding Behavior
  • Humans
  • Mice
  • Rats
  • Sensitivity and Specificity
  • Statistics
  • Leadership Positions

  • Director, Comprehensive Rodent Metabolic Phenotyping Core
  • MCW Program / Core Facilities

  • Comprehensive Rodent Metabolic Phenotyping Core
  • Educational Expertise

  • Basal Metabolism
  • Biostatistics
  • Energy Metabolism
  • Hypertension
  • Neurosciences
  • Pre-Eclampsia
  • Publications (73)

  • The BBSome in POMC and AgRP Neurons Is Necessary for Body Weight Regulation and Sorting of Metabolic Receptors. (Guo DF, Lin Z, Wu Y, Searby C, Thedens DR, Richerson GB, Usachev YM, Grobe JL, Sheffield VC, Rahmouni K) Diabetes 2019 Aug;68(8):1591-1603 PMID: 31127052 PMCID: PMC6692817 05/28/2019    
  • Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Protects From Angiotensin II-Induced Endothelial Dysfunction in Adult Offspring Born From Pregnancies Complicated by Hypertension. (Nair AR, Silva SD Jr, Agbor LN, Wu J, Nakagawa P, Mukohda M, Lu KT, Sandgren JA, Pierce GL, Santillan MK, Grobe JL, Sigmund CD) Hypertension 2019 07;74(1):173-183 PMID: 31104564 PMCID: PMC6561821 SCOPUS ID: 2-s2.0-85068196613 05/21/2019    
  • Comparison of the Effects of High-Fat Diet on Energy Flux in Mice Using Two Multiplexed Metabolic Phenotyping Systems. (Soto JE, Burnett CML, Ten Eyck P, Abel ED, Grobe JL) Obesity (Silver Spring) 2019 May;27(5):793-802 PMID: 30938081 PMCID: PMC6478533 04/03/2019       1 Citation
  • Celastrol Reduces Obesity in MC4R Deficiency and Stimulates Sympathetic Nerve Activity Affecting Metabolic and Cardiovascular Functions. (Saito K, Davis KC, Morgan DA, Toth BA, Jiang J, Singh U, Berglund ED, Grobe JL, Rahmouni K, Cui H) Diabetes 2019 06;68(6):1210-1220 PMID: 30894367 PMCID: PMC6610022 03/22/2019    
  • Liver Derived FGF21 Maintains Core Body Temperature During Acute Cold Exposure. (Ameka M, Markan KR, Morgan DA, BonDurant LD, Idiga SO, Naber MC, Zhu Z, Zingman LV, Grobe JL, Rahmouni K, Potthoff MJ) Sci Rep 2019 Jan 24;9(1):630 PMID: 30679672 PMCID: PMC6345819 01/27/2019       5 Citations
  • The renin-angiotensin system in the arcuate nucleus controls resting metabolic rate. (Deng G, Grobe JL) Curr Opin Nephrol Hypertens 2019 03;28(2):120-127 PMID: 30531199 PMCID: PMC6366639 12/12/2018       1 Citation
  • Arginine vasopressin infusion is sufficient to model clinical features of preeclampsia in mice. (Sandgren JA, Deng G, Linggonegoro DW, Scroggins SM, Perschbacher KJ, Nair AR, Nishimura TE, Zhang SY, Agbor LN, Wu J, Keen HL, Naber MC, Pearson NA, Zimmerman KA, Weiss RM, Bowdler NC, Usachev YM, Santillan DA, Potthoff MJ, Pierce GL, Gibson-Corley KN, Sigmund CD, Santillan MK, Grobe JL) JCI Insight 2018 10 04;3(19) PMID: 30282823 PMCID: PMC6237463 SCOPUS ID: 2-s2.0-85063243804 10/05/2018       8 Citations
  • Regulators of G protein signaling in cardiovascular function during pregnancy. (Perschbacher KJ, Deng G, Fisher RA, Gibson-Corley KN, Santillan MK, Grobe JL) Physiol Genomics 2018 08 01;50(8):590-604 PMID: 29702036 PMCID: PMC6139632 04/28/2018       3 Citations
  • Control of Energy Expenditure by AgRP Neurons of the Arcuate Nucleus: Neurocircuitry, Signaling Pathways, and Angiotensin. (Morselli LL, Claflin KE, Cui H, Grobe JL) Curr Hypertens Rep 2018 03 19;20(3):25 PMID: 29556733 PMCID: PMC5882211 03/21/2018       1 Citation
  • Elevated vasopressin in pregnant mice induces T-helper subset alterations consistent with human preeclampsia. (Scroggins SM, Santillan DA, Lund JM, Sandgren JA, Krotz LK, Hamilton WS, Devor EJ, Davis HA, Pierce GL, Gibson-Corley KN, Sigmund CD, Grobe JL, Santillan MK) Clin Sci (Lond) 2018 02 14;132(3):419-436 PMID: 29371289 PMCID: PMC5947858 SCOPUS ID: 2-s2.0-85046542605 01/27/2018       7 Citations
  • Angiotensin AT receptors expressed in vasopressin-producing cells of the supraoptic nucleus contribute to osmotic control of vasopressin. (Sandgren JA, Linggonegoro DW, Zhang SY, Sapouckey SA, Claflin KE, Pearson NA, Leidinger MR, Pierce GL, Santillan MK, Gibson-Corley KN, Sigmund CD, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2018 06 01;314(6):R770-R780 PMID: 29364700 PMCID: PMC6032302 SCOPUS ID: 2-s2.0-85048097812 01/25/2018       2 Citations
  • Potential mechanisms of hypothalamic renin-angiotensin system activation by leptin and DOCA-salt for the control of resting metabolism. (Sapouckey SA, Deng G, Sigmund CD, Grobe JL) Physiol Genomics 2017 Dec 01;49(12):722-732 PMID: 28986397 PMCID: PMC5814669 SCOPUS ID: 2-s2.0-85044192981 10/08/2017       5 Citations
  • MRAP2 regulates ghrelin receptor signaling and hunger sensing. (Srisai D, Yin TC, Lee AA, Rouault AAJ, Pearson NA, Grobe JL, Sebag JA) Nat Commun 2017 09 28;8(1):713 PMID: 28959025 PMCID: PMC5620068 09/30/2017       9 Citations
  • Selective Deletion of Renin-b in the Brain Alters Drinking and Metabolism. (Shinohara K, Nakagawa P, Gomez J, Morgan DA, Littlejohn NK, Folchert MD, Weidemann BJ, Liu X, Walsh SA, Ponto LL, Rahmouni K, Grobe JL, Sigmund CD) Hypertension 2017 11;70(5):990-997 PMID: 28874461 PMCID: PMC5679092 SCOPUS ID: 2-s2.0-85031820971 09/07/2017       4 Citations
  • Comprehensive Assessments of Energy Balance in Mice. (Grobe JL) Methods Mol Biol 2017;1614:123-146 PMID: 28500600 PMCID: PMC5582947 05/14/2017       7 Citations
  • Evidence for intraventricular secretion of angiotensinogen and angiotensin by the subfornical organ using transgenic mice. (Agassandian K, Grobe JL, Liu X, Agassandian M, Thompson AP, Sigmund CD, Cassell MD) Am J Physiol Regul Integr Comp Physiol 2017 06 01;312(6):R973-R981 PMID: 28490451 PMCID: PMC5495920 SCOPUS ID: 2-s2.0-85020436522 05/12/2017       3 Citations
  • The Gut Microbiome, Energy Homeostasis, and Implications for Hypertension. (Riedl RA, Atkinson SN, Burnett CML, Grobe JL, Kirby JR) Curr Hypertens Rep 2017 Apr;19(4):27 PMID: 28316052 PMCID: PMC5773096 SCOPUS ID: 2-s2.0-85015782153 03/21/2017       8 Citations
  • Angiotensin AT1A receptors on leptin receptor-expressing cells control resting metabolism. (Claflin KE, Sandgren JA, Lambertz AM, Weidemann BJ, Littlejohn NK, Burnett CM, Pearson NA, Morgan DA, Gibson-Corley KN, Rahmouni K, Grobe JL) J Clin Invest 2017 Apr 03;127(4):1414-1424 PMID: 28263184 PMCID: PMC5373887 03/07/2017       18 Citations
  • Selective Deletion of the Brain-Specific Isoform of Renin Causes Neurogenic Hypertension. (Shinohara K, Liu X, Morgan DA, Davis DR, Sequeira-Lopez ML, Cassell MD, Grobe JL, Rahmouni K, Sigmund CD) Hypertension 2016 12;68(6):1385-1392 PMID: 27754863 PMCID: PMC5159235 SCOPUS ID: 2-s2.0-84991696091 10/19/2016       14 Citations
  • Obesity alters immune and metabolic profiles: New insight from obese-resistant mice on high-fat diet. (Boi SK, Buchta CM, Pearson NA, Francis MB, Meyerholz DK, Grobe JL, Norian LA) Obesity (Silver Spring) 2016 10;24(10):2140-9 PMID: 27515998 PMCID: PMC5039085 08/16/2016       16 Citations
  • Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. (Littlejohn NK, Keen HL, Weidemann BJ, Claflin KE, Tobin KV, Markan KR, Park S, Naber MC, Gourronc FA, Pearson NA, Liu X, Morgan DA, Klingelhutz AJ, Potthoff MJ, Rahmouni K, Sigmund CD, Grobe JL) Cell Rep 2016 08 09;16(6):1548-1560 PMID: 27477281 PMCID: PMC4981564 SCOPUS ID: 2-s2.0-84979752805 08/02/2016       18 Citations
  • mTORC1 Signaling Contributes to Drinking But Not Blood Pressure Responses to Brain Angiotensin II. (Muta K, Morgan DA, Grobe JL, Sigmund CD, Rahmouni K) Endocrinology 2016 08;157(8):3140-8 PMID: 27254006 PMCID: PMC4967111 SCOPUS ID: 2-s2.0-84982797786 06/03/2016       4 Citations
  • Breaking a Mother's Heart: Circulating Antiangiogenic Factors and Hypertension During Pregnancy Correlate With Specific Cardiac Dysfunctions. (Sandgren JA, Santillan MK, Grobe JL) Hypertension 2016 06;67(6):1119-20 PMID: 27113050 PMCID: PMC4865412 04/27/2016       1 Citation
  • The BBSome Controls Energy Homeostasis by Mediating the Transport of the Leptin Receptor to the Plasma Membrane. (Guo DF, Cui H, Zhang Q, Morgan DA, Thedens DR, Nishimura D, Grobe JL, Sheffield VC, Rahmouni K) PLoS Genet 2016 Feb;12(2):e1005890 PMID: 26926121 PMCID: PMC4771807 03/02/2016       29 Citations
  • Introduction to the American Heart Association's Hypertension Strategically Focused Research Network. (Muntner P, Becker RC, Calhoun D, Chen D, Cowley AW Jr, Flynn JT, Grobe JL, Kidambi S, Kotchen TA, Lackland DT, Leslie KK, Li Y, Liang M, Lloyd A, Mattson DL, Mendizabal B, Mitsnefes M, Nair A, Pierce GL, Pollock JS, Safford MM, Santillan MK, Sigmund CD, Thomas SJ, Urbina EM) Hypertension 2016 Apr;67(4):674-80 PMID: 26902490 PMCID: PMC5135412 SCOPUS ID: 2-s2.0-84960812805 02/24/2016       4 Citations
  • Risperidone-induced weight gain is mediated through shifts in the gut microbiome and suppression of energy expenditure. (Bahr SM, Weidemann BJ, Castro AN, Walsh JW, deLeon O, Burnett CM, Pearson NA, Murry DJ, Grobe JL, Kirby JR) EBioMedicine 2015 11;2(11):1725-34 PMID: 26870798 PMCID: PMC4740326 SCOPUS ID: 2-s2.0-84958879311 02/13/2016       39 Citations
  • Heat acclimation and thirst in rats. (Barney CC, Schanhals EM, Grobe JL, Andresen BT, Traver M) Physiol Rep 2015 Dec;3(12) PMID: 26702076 PMCID: PMC4760436 12/25/2015    
  • Protective Role for Tissue Inhibitor of Metalloproteinase-4, a Novel Peroxisome Proliferator-Activated Receptor-γ Target Gene, in Smooth Muscle in Deoxycorticosterone Acetate-Salt Hypertension. (Ketsawatsomkron P, Keen HL, Davis DR, Lu KT, Stump M, De Silva TM, Hilzendeger AM, Grobe JL, Faraci FM, Sigmund CD) Hypertension 2016 Jan;67(1):214-22 PMID: 26597823 PMCID: PMC4679422 SCOPUS ID: 2-s2.0-84950335650 11/26/2015       12 Citations
  • Opposing tissue-specific roles of angiotensin in the pathogenesis of obesity, and implications for obesity-related hypertension. (Littlejohn NK, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2015 Dec 15;309(12):R1463-73 PMID: 26491099 PMCID: PMC4698411 10/23/2015       15 Citations
  • Dietary Sodium Suppresses Digestive Efficiency via the Renin-Angiotensin System. (Weidemann BJ, Voong S, Morales-Santiago FI, Kahn MZ, Ni J, Littlejohn NK, Claflin KE, Burnett CM, Pearson NA, Lutter ML, Grobe JL) Sci Rep 2015 Jun 11;5:11123 PMID: 26068176 PMCID: PMC4464075 06/13/2015       13 Citations
  • Brain endoplasmic reticulum stress mechanistically distinguishes the saline-intake and hypertensive response to deoxycorticosterone acetate-salt. (Jo F, Jo H, Hilzendeger AM, Thompson AP, Cassell MD, Rutkowski DT, Davisson RL, Grobe JL, Sigmund CD) Hypertension 2015 Jun;65(6):1341-8 PMID: 25895586 PMCID: PMC4433403 SCOPUS ID: 2-s2.0-84937622096 04/22/2015       11 Citations
  • Control of energy balance by the brain renin-angiotensin system. (Claflin KE, Grobe JL) Curr Hypertens Rep 2015 May;17(5):38 PMID: 25833461 04/04/2015       17 Citations
  • Vasopressin: the missing link for preeclampsia? (Sandgren JA, Scroggins SM, Santillan DA, Devor EJ, Gibson-Corley KN, Pierce GL, Sigmund CD, Santillan MK, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2015 Nov 01;309(9):R1062-4 PMID: 25810383 PMCID: PMC4666952 SCOPUS ID: 2-s2.0-84946088245 03/27/2015       16 Citations
  • Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes. (Santillan MK, Pelham CJ, Ketsawatsomkron P, Santillan DA, Davis DR, Devor EJ, Gibson-Corley KN, Scroggins SM, Grobe JL, Yang B, Hunter SK, Sigmund CD) Physiol Rep 2015 Jan 01;3(1) PMID: 25602015 PMCID: PMC4387753 01/21/2015    
  • Mechanisms of brain renin angiotensin system-induced drinking and blood pressure: importance of the subfornical organ. (Coble JP, Grobe JL, Johnson AK, Sigmund CD) Am J Physiol Regul Integr Comp Physiol 2015 Feb 15;308(4):R238-49 PMID: 25519738 PMCID: PMC4347751 SCOPUS ID: 2-s2.0-84923163679 12/19/2014       39 Citations
  • Direct pro-inflammatory effects of prorenin on microglia. (Shi P, Grobe JL, Desland FA, Zhou G, Shen XZ, Shan Z, Liu M, Raizada MK, Sumners C) PLoS One 2014;9(10):e92937 PMID: 25302502 PMCID: PMC4193744 10/11/2014       44 Citations
  • A mitochondrial-targeted coenzyme q analog prevents weight gain and ameliorates hepatic dysfunction in high-fat-fed mice. (Fink BD, Herlein JA, Guo DF, Kulkarni C, Weidemann BJ, Yu L, Grobe JL, Rahmouni K, Kerns RJ, Sivitz WI) J Pharmacol Exp Ther 2014 Dec;351(3):699-708 PMID: 25301169 PMCID: PMC4244581 10/11/2014       18 Citations
  • Another reason to eat your greens: cardiopulmonary protection by dietary delivery of angiotensin-converting enzyme-2 and angiotensin-(1-7) made in plants. (Grobe JL, Sigmund CD) Hypertension 2014 Dec;64(6):1182-3 PMID: 25225201 SCOPUS ID: 2-s2.0-84927797099 09/17/2014       2 Citations
  • Role of vascular smooth muscle PPARγ in regulating AT1 receptor signaling and angiotensin II-dependent hypertension. (Carrillo-Sepulveda MA, Keen HL, Davis DR, Grobe JL, Sigmund CD) PLoS One 2014;9(8):e103786 PMID: 25122005 PMCID: PMC4133177 SCOPUS ID: 2-s2.0-84905989058 08/15/2014       9 Citations
  • Ablation of the GNB3 gene in mice does not affect body weight, metabolism or blood pressure, but causes bradycardia. (Ye Y, Sun Z, Guo A, Song LS, Grobe JL, Chen S) Cell Signal 2014 Nov;26(11):2514-20 PMID: 25093805 PMCID: PMC4160384 08/06/2014       7 Citations
  • Vasopressin in preeclampsia: a novel very early human pregnancy biomarker and clinically relevant mouse model. (Santillan MK, Santillan DA, Scroggins SM, Min JY, Sandgren JA, Pearson NA, Leslie KK, Hunter SK, Zamba GK, Gibson-Corley KN, Grobe JL) Hypertension 2014 Oct;64(4):852-9 PMID: 25001273 PMCID: PMC4162750 07/09/2014       52 Citations
  • Activation of the renin-angiotensin system, specifically in the subfornical organ is sufficient to induce fluid intake. (Coble JP, Cassell MD, Davis DR, Grobe JL, Sigmund CD) Am J Physiol Regul Integr Comp Physiol 2014 Aug 15;307(4):R376-86 PMID: 24965793 PMCID: PMC4137154 SCOPUS ID: 2-s2.0-84907637962 06/27/2014       13 Citations
  • Dietary effects on resting metabolic rate in C57BL/6 mice are differentially detected by indirect (O2/CO2 respirometry) and direct calorimetry. (Burnett CM, Grobe JL) Mol Metab 2014 Jul;3(4):460-4 PMID: 24944905 PMCID: PMC4060218 06/20/2014    
  • Activity of protein kinase C-α within the subfornical organ is necessary for fluid intake in response to brain angiotensin. (Coble JP, Johnson RF, Cassell MD, Johnson AK, Grobe JL, Sigmund CD) Hypertension 2014 Jul;64(1):141-8 PMID: 24777977 PMCID: PMC4057298 SCOPUS ID: 2-s2.0-84902551083 04/30/2014       16 Citations
  • Neuron-specific (pro)renin receptor knockout prevents the development of salt-sensitive hypertension. (Li W, Peng H, Mehaffey EP, Kimball CD, Grobe JL, van Gool JM, Sullivan MN, Earley S, Danser AH, Ichihara A, Feng Y) Hypertension 2014 Feb;63(2):316-23 PMID: 24246383 PMCID: PMC3947277 11/20/2013    
  • Direct calorimetry identifies deficiencies in respirometry for the determination of resting metabolic rate in C57Bl/6 and FVB mice. (Burnett CM, Grobe JL) Am J Physiol Endocrinol Metab 2013 Oct 01;305(7):E916-24 PMID: 23964071 PMCID: PMC3798702 08/22/2013       20 Citations
  • Hypertension in mice with transgenic activation of the brain renin-angiotensin system is vasopressin dependent. (Littlejohn NK, Siel RB Jr, Ketsawatsomkron P, Pelham CJ, Pearson NA, Hilzendeger AM, Buehrer BA, Weidemann BJ, Li H, Davis DR, Thompson AP, Liu X, Cassell MD, Sigmund CD, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2013 May 15;304(10):R818-28 PMID: 23535460 PMCID: PMC3652167 SCOPUS ID: 2-s2.0-84878651210 03/29/2013       39 Citations
  • Angiotensin type 1a receptors in the subfornical organ are required for deoxycorticosterone acetate-salt hypertension. (Hilzendeger AM, Cassell MD, Davis DR, Stauss HM, Mark AL, Grobe JL, Sigmund CD) Hypertension 2013 Mar;61(3):716-22 PMID: 23266541 PMCID: PMC3573251 SCOPUS ID: 2-s2.0-84874360680 12/26/2012       35 Citations
  • The adipose/circulating renin-angiotensin system cross-talk enters a new dimension. (Grobe JL, Rahmouni K) Hypertension 2012 Dec;60(6):1389-90 PMID: 23108659 PMCID: PMC3959780 10/31/2012       5 Citations
  • Cullin-3 regulates vascular smooth muscle function and arterial blood pressure via PPARγ and RhoA/Rho-kinase. (Pelham CJ, Ketsawatsomkron P, Groh S, Grobe JL, de Lange WJ, Ibeawuchi SR, Keen HL, Weatherford ET, Faraci FM, Sigmund CD) Cell Metab 2012 Oct 03;16(4):462-72 PMID: 23040068 PMCID: PMC3474846 SCOPUS ID: 2-s2.0-84867084491 10/09/2012       54 Citations
  • PPARγ regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity. (Ketsawatsomkron P, Lorca RA, Keen HL, Weatherford ET, Liu X, Pelham CJ, Grobe JL, Faraci FM, England SK, Sigmund CD) Circ Res 2012 Nov 09;111(11):1446-58 PMID: 22962432 PMCID: PMC3494760 SCOPUS ID: 2-s2.0-84870039725 09/11/2012       38 Citations
  • A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity. (Hilzendeger AM, Morgan DA, Brooks L, Dellsperger D, Liu X, Grobe JL, Rahmouni K, Sigmund CD, Mark AL) Am J Physiol Heart Circ Physiol 2012 Jul 15;303(2):H197-206 PMID: 22610169 PMCID: PMC3404702 SCOPUS ID: 2-s2.0-84864011880 05/23/2012       73 Citations
  • Metabolic rate regulation by the renin-angiotensin system: brain vs. body. (Grobe JL, Rahmouni K, Liu X, Sigmund CD) Pflugers Arch 2013 Jan;465(1):167-75 PMID: 22491893 PMCID: PMC3569511 SCOPUS ID: 2-s2.0-84873056337 04/12/2012       16 Citations
  • Editorial focus: A fat contribution to RAS activation and blood pressure control: evidence from angiotensinogen conditional null mice. Focus on: "Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice.". (Grobe JL, Rahmouni K) Am J Physiol Regul Integr Comp Physiol 2012 Jan 15;302(2):R242-3 PMID: 22071163 11/11/2011    
  • Renal proximal tubule angiotensin AT1A receptors regulate blood pressure. (Li H, Weatherford ET, Davis DR, Keen HL, Grobe JL, Daugherty A, Cassis LA, Allen AM, Sigmund CD) Am J Physiol Regul Integr Comp Physiol 2011 Oct;301(4):R1067-77 PMID: 21753145 PMCID: PMC3197336 SCOPUS ID: 2-s2.0-80053655134 07/15/2011       48 Citations
  • Angiotensinergic signaling in the brain mediates metabolic effects of deoxycorticosterone (DOCA)-salt in C57 mice. (Grobe JL, Buehrer BA, Hilzendeger AM, Liu X, Davis DR, Xu D, Sigmund CD) Hypertension 2011 Mar;57(3):600-7 PMID: 21263123 PMCID: PMC3144490 SCOPUS ID: 2-s2.0-79953191408 01/26/2011       46 Citations
  • Neuron- or glial-specific ablation of secreted renin does not affect renal renin, baseline arterial pressure, or metabolism. (Xu D, Borges GR, Davis DR, Agassandian K, Sequeira Lopez ML, Gomez RA, Cassell MD, Grobe JL, Sigmund CD) Physiol Genomics 2011 Mar 29;43(6):286-94 PMID: 21189370 PMCID: PMC3068515 SCOPUS ID: 2-s2.0-79955774465 12/30/2010       16 Citations
  • The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance. (Grobe JL, Grobe CL, Beltz TG, Westphal SG, Morgan DA, Xu D, de Lange WJ, Li H, Sakai K, Thedens DR, Cassis LA, Rahmouni K, Mark AL, Johnson AK, Sigmund CD) Cell Metab 2010 Nov 03;12(5):431-42 PMID: 21035755 PMCID: PMC2994017 SCOPUS ID: 2-s2.0-78049448391 11/03/2010       88 Citations
  • Cardiovascular consequences of genetic variation at -6/235 in human angiotensinogen using "humanized" gene-targeted mice. (Grobe JL, Dickson ME, Park S, Davis DR, Born EJ, Sigmund CD) Hypertension 2010 Nov;56(5):981-7 PMID: 20823378 PMCID: PMC2959143 SCOPUS ID: 2-s2.0-78149258856 09/09/2010       8 Citations
  • Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin. (Xu D, Borges GR, Grobe JL, Pelham CJ, Yang B, Sigmund CD) Hypertension 2009 Dec;54(6):1240-7 PMID: 19822797 PMCID: PMC2783841 SCOPUS ID: 2-s2.0-73349119699 10/14/2009       30 Citations
  • 17beta-Estradiol modulates local cardiac renin-angiotensin system to prevent cardiac remodeling in the DOCA-salt model of hypertension in rats. (Shenoy V, Grobe JL, Qi Y, Ferreira AJ, Fraga-Silva RA, Collamat G, Bruce E, Katovich MJ) Peptides 2009 Dec;30(12):2309-15 PMID: 19747516 09/15/2009       28 Citations
  • PPARgamma differentially regulates energy substrate handling in brown vs. white adipose: focus on "The PPARgamma agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake". (Grobe JL, Venegas-Pont M, Sigmund CD, Ryan MJ) Am J Physiol Regul Integr Comp Physiol 2009 May;296(5):R1325-6 PMID: 19261916 PMCID: PMC3597227 SCOPUS ID: 2-s2.0-66149112458 03/06/2009       3 Citations
  • Angiotensin-(1-7) as an antihypertensive, antifibrotic target. (Katovich MJ, Grobe JL, Raizada MK) Curr Hypertens Rep 2008 Jun;10(3):227-32 PMID: 18765095 09/04/2008       30 Citations
  • An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy. (Grobe JL, Xu D, Sigmund CD) Physiology (Bethesda) 2008 Aug;23:187-93 PMID: 18697992 PMCID: PMC2538674 SCOPUS ID: 2-s2.0-53749104976 08/14/2008       99 Citations
  • Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiology. (Der Sarkissian S, Grobe JL, Yuan L, Narielwala DR, Walter GA, Katovich MJ, Raizada MK) Hypertension 2008 Mar;51(3):712-8 PMID: 18250366 02/06/2008       95 Citations
  • ACE2 overexpression inhibits hypoxia-induced collagen production by cardiac fibroblasts. (Grobe JL, Der Sarkissian S, Stewart JM, Meszaros JG, Raizada MK, Katovich MJ) Clin Sci (Lond) 2007 Oct;113(8):357-64 PMID: 17600530 06/30/2007       60 Citations
  • Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7). (Grobe JL, Mecca AP, Lingis M, Shenoy V, Bolton TA, Machado JM, Speth RC, Raizada MK, Katovich MJ) Am J Physiol Heart Circ Physiol 2007 Feb;292(2):H736-42 PMID: 17098828 11/14/2006       243 Citations
  • Potentiation of the antihypertensive action of losartan by peripheral overexpression of the ANG II type 2 receptor. (Li H, Gao Y, Grobe JL, Raizada MK, Katovich MJ, Sumners C) Am J Physiol Heart Circ Physiol 2007 Feb;292(2):H727-35 PMID: 17085538 11/07/2006       23 Citations
  • Chronic angiotensin-(1-7) prevents cardiac fibrosis in DOCA-salt model of hypertension. (Grobe JL, Mecca AP, Mao H, Katovich MJ) Am J Physiol Heart Circ Physiol 2006 Jun;290(6):H2417-23 PMID: 16415071 01/18/2006       144 Citations
  • Alterations in aortic vascular reactivity to angiotensin 1-7 in 17-beta-estradiol-treated female SD rats. (Grobe JL, Katovich MJ) Regul Pept 2006 Jan 15;133(1-3):62-7 PMID: 16219374 10/13/2005       8 Citations
  • Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats. (Huentelman MJ, Grobe JL, Vazquez J, Stewart JM, Mecca AP, Katovich MJ, Ferrario CM, Raizada MK) Exp Physiol 2005 Sep;90(5):783-90 PMID: 16049057 07/29/2005       165 Citations
  • Angiotensin-converting enzyme 2 as a novel target for gene therapy for hypertension. (Katovich MJ, Grobe JL, Huentelman M, Raizada MK) Exp Physiol 2005 May;90(3):299-305 PMID: 15640278 01/11/2005       24 Citations
  • Thermal dehydration-induced thirst in lithium-treated rats. (Barney CC, Kurylo DM, Grobe JL) Pharmacol Biochem Behav 2003 May;75(2):341-7 PMID: 12873625 07/23/2003       2 Citations
  • Last update: 12/03/2019
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