Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Olena Isaeva PhD

Olena Isaeva PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Cell Biology, Neurobiology and Anatomy
Program: Administration


I am willing to mentor a junior faculty member.
I am willing to collaborate on research projects.

View Curriculum Vitae

Publications (55)

  • Crosstalk between epithelial sodium channels (ENaC) and basolateral potassium channels (Kir 4.1/Kir 5.1) in the cortical collecting duct. (Isaeva E, Bohovyk R, Fedoriuk M, Shalygin A, Klemens CA, Zietara A, Levchenko V, Denton JS, Staruschenko A, Palygin O) Br J Pharmacol 2022 Jun;179(12):2953-2968 PMID: 34904226 PMCID: PMC9106811 SCOPUS ID: 2-s2.0-85124542688 12/15/2021    
  • Role of collecting duct principal cell NOS1β in sodium and potassium homeostasis. (Hyndman KA, Isaeva E, Palygin O, Mendoza LD, Rodan AR, Staruschenko A, Pollock JS) Physiol Rep 2021 10;9(20):e15080 PMID: 34665521 PMCID: PMC8525323 SCOPUS ID: 2-s2.0-85118118628 10/20/2021    
  • Characterization of purinergic receptor 2 signaling in podocytes from diabetic kidneys. (Palygin O, Klemens CA, Isaeva E, Levchenko V, Spires DR, Dissanayake LV, Nikolaienko O, Ilatovskaya DV, Staruschenko A) iScience 2021 Jun 25;24(6):102528 PMID: 34142040 PMCID: PMC8188476 SCOPUS ID: 2-s2.0-85106559673 06/19/2021       2 Citations
  • Sexual dimorphism in the progression of type 2 diabetic kidney disease in T2DN rats. (Spires DR, Palygin O, Levchenko V, Isaeva E, Klemens CA, Khedr S, Nikolaienko O, Kriegel A, Cheng X, Yeo JY, Joe B, Staruschenko A) Physiol Genomics 2021 06 01;53(6):223-234 PMID: 33870721 PMCID: PMC8285576 SCOPUS ID: 2-s2.0-85108022875 04/20/2021    
  • Scanning ion conductance microscopy of live human glomerulus. (Bohovyk R, Fedoriuk M, Isaeva E, Shevchuk A, Palygin O, Staruschenko A) J Cell Mol Med 2021 05;25(9):4216-4219 PMID: 33745233 PMCID: PMC8093965 SCOPUS ID: 2-s2.0-85102841283 03/22/2021       1 Citation
  • Kcnj16 knockout produces audiogenic seizures in the Dahl salt-sensitive rat. (Manis AD, Palygin O, Isaeva E, Levchenko V, LaViolette PS, Pavlov TS, Hodges MR, Staruschenko A) JCI Insight 2021 01 11;6(1) PMID: 33232300 PMCID: PMC7821607 SCOPUS ID: 2-s2.0-85099291307 11/25/2020       3 Citations
  • Behavioral, metabolic, and renal outcomes of 1-month isolation in adolescent male Dahl salt-sensitive rats. (Nikolaienko O, Isaeva E, Levchenko V, Palygin O, Staruschenko A) Am J Physiol Regul Integr Comp Physiol 2020 12 01;319(6):R684-R689 PMID: 33052061 PMCID: PMC7792816 SCOPUS ID: 2-s2.0-85098454395 10/15/2020       2 Citations
  • Role of opioid signaling in kidney damage during the development of salt-induced hypertension. (Golosova D, Palygin O, Bohovyk R, Klemens CA, Levchenko V, Spires DR, Isaeva E, El-Meanawy A, Staruschenko A) Life Sci Alliance 2020 12;3(12) PMID: 33046522 PMCID: PMC7556751 SCOPUS ID: 2-s2.0-85092887222 10/14/2020       5 Citations
  • NOX4-dependent regulation of ENaC in hypertension and diabetic kidney disease. (Pavlov TS, Palygin O, Isaeva E, Levchenko V, Khedr S, Blass G, Ilatovskaya DV, Cowley AW Jr, Staruschenko A) FASEB J 2020 10;34(10):13396-13408 PMID: 32799394 PMCID: PMC7722042 SCOPUS ID: 2-s2.0-85089380202 08/18/2020       4 Citations
  • Experimental models in the study of the mechanisms and consequences of epileptic seizures in neonatal period of life (Romanov A, Isaeva E) Fiziologichnyi Zhurnal 2020;66(2-3):93-100 SCOPUS ID: 2-s2.0-85107411208 01/01/2020    
  • Vibrodissociation method for isolation of defined nephron segments from human and rodent kidneys. (Isaeva E, Fedoriuk M, Bohovyk R, Klemens CA, Khedr S, Golosova D, Levchenko V, El-Meanawy A, Palygin O, Staruschenko A) Am J Physiol Renal Physiol 2019 11 01;317(5):F1398-F1403 PMID: 31588797 PMCID: PMC6879945 SCOPUS ID: 2-s2.0-85074674820 10/08/2019       5 Citations
  • Salt-deficient diet exacerbates cystogenesis in ARPKD via epithelial sodium channel (ENaC). (Ilatovskaya DV, Levchenko V, Pavlov TS, Isaeva E, Klemens CA, Johnson J, Liu P, Kriegel AJ, Staruschenko A) EBioMedicine 2019 Feb;40:663-674 PMID: 30745171 PMCID: PMC6413684 SCOPUS ID: 2-s2.0-85061112508 02/13/2019       18 Citations
  • Inhibition of protease-activated receptor 1 ameliorates behavioral deficits and restores hippocampal synaptic plasticity in a rat model of status epilepticus. (Semenikhina M, Bogovyk R, Fedoriuk M, Nikolaienko O, Al Kury LT, Savotchenko A, Krishtal O, Isaeva E) Neurosci Lett 2019 01 23;692:64-68 PMID: 30391321 SCOPUS ID: 2-s2.0-85056000942 11/06/2018       8 Citations
  • Effects of protease-activated receptor 1 inhibition on anxiety and fear following status epilepticus. (Bogovyk R, Lunko O, Fedoriuk M, Isaev D, Krishtal O, Holmes GL, Isaeva E) Epilepsy Behav 2017 02;67:66-69 PMID: 28088683 SCOPUS ID: 2-s2.0-85009121782 01/16/2017       7 Citations
  • Acid-sensing ion channels regulate spontaneous inhibitory activity in the hippocampus: possible implications for epilepsy. (Ievglevskyi O, Isaev D, Netsyk O, Romanov A, Fedoriuk M, Maximyuk O, Isaeva E, Akaike N, Krishtal O) Philos Trans R Soc Lond B Biol Sci 2016 08 05;371(1700) PMID: 27377725 PMCID: PMC4938031 SCOPUS ID: 2-s2.0-84977577073 07/06/2016       19 Citations
  • Modulation of 4-aminopyridine-induced neuronal activity and local pO(2)in rat hippocampal slices by changing the flow rate of the superfusion medium. (Sydorenko VG, Komarov OS, Sushko BS, Romanov AK, Isaeva EV, Isaev DS) Fiziol Zh 2016;62(4):3-11 PMID: 29975468 SCOPUS ID: 2-s2.0-85051038034 01/01/2016    
  • Surface charge impact in nonsynaptic model of epilepsy in rat hippocampus. (Zapukhliak OS, Kachanovska VO, Isaeva EV, Netsyk OV, Isaev DS) Fiziol Zh 2016;62(2):35-40 PMID: 29537223 SCOPUS ID: 2-s2.0-85044617034 01/01/2016       1 Citation
  • Thrombin modulates persistent sodium current in CA1 pyramidal neurons of young and adult rat hippocampus. (Lunko OO, Isaev DS, Krishtal OO, Isaeva EV) Fiziol Zh 2015;61(4):5-10 PMID: 26552299 SCOPUS ID: 2-s2.0-84952719146 11/11/2015       1 Citation
  • Novel Potent Orthosteric Antagonist of ASIC1a Prevents NMDAR-Dependent LTP Induction. (Buta A, Maximyuk O, Kovalskyy D, Sukach V, Vovk M, Ievglevskyi O, Isaeva E, Isaev D, Savotchenko A, Krishtal O) J Med Chem 2015 Jun 11;58(11):4449-61 PMID: 25974655 SCOPUS ID: 2-s2.0-84935857385 05/15/2015       24 Citations
  • Hippocampal GABAergic interneurons coexpressing alpha7-nicotinic receptors and connexin-36 are able to improve neuronal viability under oxygen-glucose deprivation. (Voytenko LP, Lushnikova IV, Savotchenko AV, Isaeva EV, Skok MV, Lykhmus OY, Patseva MA, Skibo GG) Brain Res 2015 Aug 07;1616:134-45 PMID: 25966616 SCOPUS ID: 2-s2.0-84975110841 05/15/2015       15 Citations
  • Contribution of protease-activated receptor 1 in status epilepticus-induced epileptogenesis. (Isaev D, Lushnikova I, Lunko O, Zapukhliak O, Maximyuk O, Romanov A, Skibo GG, Tian C, Holmes GL, Isaeva E) Neurobiol Dis 2015 Jun;78:68-76 PMID: 25843668 PMCID: PMC4682556 SCOPUS ID: 2-s2.0-84926617762 04/07/2015       15 Citations
  • Neuraminidase inhibition primes short-term depression and suppresses long-term potentiation of synaptic transmission in the rat hippocampus. (Savotchenko A, Romanov A, Isaev D, Maximyuk O, Sydorenko V, Holmes GL, Isaeva E) Neural Plast 2015;2015:908190 PMID: 25802763 PMCID: PMC4329761 SCOPUS ID: 2-s2.0-84937134215 03/25/2015       5 Citations
  • Status epilepticus results in region-specific alterations in seizure susceptibility along the hippocampal longitudinal axis. (Isaeva E, Romanov A, Holmes GL, Isaev D) Epilepsy Res 2015 Feb;110:166-70 PMID: 25616469 PMCID: PMC4361808 SCOPUS ID: 2-s2.0-84921317713 01/27/2015       6 Citations
  • [EFFECT OF NEONATAL SEIZURES ON THE SYNAPTIC PLASTICITY OF RAT SOMATOSENSORY CORTEX]. (Isaeva EV, Lunko OO, Romano AK, Isaev DS) Fiziol Zh 2015;61(6):11-6 PMID: 27025040 SCOPUS ID: 2-s2.0-84988799233 01/01/2015    
  • Persistent sodium current properties in hippocampal CA1 pyramidal neurons of young and adult rats. (Lunko O, Isaev D, Maximyuk O, Ivanchick G, Sydorenko V, Krishtal O, Isaeva E) Neurosci Lett 2014 Jan 24;559:30-3 PMID: 24300033 SCOPUS ID: 2-s2.0-84890275510 12/05/2013       6 Citations
  • Focal epileptiform activity in the prefrontal cortex is associated with long-term attention and sociability deficits. (Hernan AE, Alexander A, Jenks KR, Barry J, Lenck-Santini PP, Isaeva E, Holmes GL, Scott RC) Neurobiol Dis 2014 Mar;63:25-34 PMID: 24269731 PMCID: PMC4397918 SCOPUS ID: 2-s2.0-84890289984 11/26/2013       50 Citations
  • Alteration of synaptic plasticity by neonatal seizures in rat somatosensory cortex. (Isaeva E, Isaev D, Holmes GL) Epilepsy Res 2013 Sep;106(1-2):280-3 PMID: 23623846 PMCID: PMC3758912 SCOPUS ID: 2-s2.0-84883296500 04/30/2013       26 Citations
  • Altered short-term plasticity in the prefrontal cortex after early life seizures. (Hernan AE, Holmes GL, Isaev D, Scott RC, Isaeva E) Neurobiol Dis 2013 Feb;50:120-6 PMID: 23064435 PMCID: PMC3534893 SCOPUS ID: 2-s2.0-84868488002 10/16/2012       35 Citations
  • Thrombin facilitates seizures through activation of persistent sodium current. (Isaeva E, Hernan A, Isaev D, Holmes GL) Ann Neurol 2012 Aug;72(2):192-8 PMID: 22926852 PMCID: PMC3430976 SCOPUS ID: 2-s2.0-84865595035 08/29/2012       26 Citations
  • Electrolyte therapy reduces spike-and-wave discharges in the WAG/Rij rat model of absence epilepsy. (Talnov AN, Isaeva E, Savotchenko AV, Dovgalets GV, Ochoa JG, Holmes GL, Isaev D) Epilepsy Behav 2012 Aug;24(4):399-402 PMID: 22749239 PMCID: PMC3408819 SCOPUS ID: 2-s2.0-84864296914 07/04/2012       1 Citation
  • Effect of neonatal epileptic attacks on the activity of neocortical neurons (Isaev DS, Isaeva EV, Savrasova AV, Holmes GL) Neurophysiology November 2011;43(3):227-228 SCOPUS ID: 2-s2.0-83555166011 11/01/2011    
  • Surface charge impact in low-magnesium model of seizure in rat hippocampus. (Isaev D, Ivanchick G, Khmyz V, Isaeva E, Savrasova A, Krishtal O, Holmes GL, Maximyuk O) J Neurophysiol 2012 Jan;107(1):417-23 PMID: 22031777 PMCID: PMC3349697 SCOPUS ID: 2-s2.0-84255182503 10/28/2011       38 Citations
  • Effect of neuraminidase treatment on persistent epileptiform activity in the rat hippocampus. (Isaeva E, Lushnikova I, Savrasova A, Skibo G, Holmes GL, Isaev D) Pharmacol Rep 2011;63(3):840-4 PMID: 21857096 08/23/2011    
  • Anaesthetic and postanaesthetic effect of isoflurane on the multiple-unit activity of the immature rat hippocampus. (Isaeva EV, Isaev DS) Fiziol Zh 2011;57(1):17-20 PMID: 21513222 SCOPUS ID: 2-s2.0-79957717683 04/26/2011    
  • Neuroaminidase reduces interictal spikes in a rat temporal lobe epilepsy model. (Isaev D, Zhao Q, Kleen JK, Lenck-Santini PP, Adstamongkonkul D, Isaeva E, Holmes GL) Epilepsia 2011 Mar;52(3):e12-5 PMID: 21366554 PMCID: PMC3265164 SCOPUS ID: 2-s2.0-79952541120 03/04/2011       9 Citations
  • Effect of neuraminidase treatment on persistent epileptiform activity in the rat hippocampus (Isaeva E, Lushnikova I, Savrasova A, Skibo G, Holmes GL, Isaev D) Pharmacological Reports 2011;63(3):840-844 SCOPUS ID: 2-s2.0-80051523283 01/01/2011       7 Citations
  • Blockade of endogenous neuraminidase leads to an increase of neuronal excitability and activity-dependent synaptogenesis in the rat hippocampus. (Isaeva E, Lushnikova I, Savrasova A, Skibo G, Holmes GL, Isaev D) Eur J Neurosci 2010 Dec;32(11):1889-96 PMID: 21044183 SCOPUS ID: 2-s2.0-78649708532 11/04/2010       14 Citations
  • The effect of neuraminidase blocker on gabazine-induced seizures in rat hippocampus. (Savrasova AV, Lushnikova IV, Isaeva EV, Skibo GG, Isaev DS, Kostyuk PG) Fiziol Zh 2010;56(4):14-8 PMID: 20964139 SCOPUS ID: 2-s2.0-79952066143 10/23/2010       5 Citations
  • Recurrent neonatal seizures result in long-term increases in neuronal network excitability in the rat neocortex. (Isaeva E, Isaev D, Savrasova A, Khazipov R, Holmes GL) Eur J Neurosci 2010 Apr;31(8):1446-55 PMID: 20384780 PMCID: PMC3148010 SCOPUS ID: 2-s2.0-77951155970 04/14/2010       41 Citations
  • Long-term suppression of GABAergic activity by neonatal seizures in rat somatosensory cortex. (Isaeva E, Isaev D, Khazipov R, Holmes GL) Epilepsy Res 2009 Dec;87(2-3):286-9 PMID: 19828295 PMCID: PMC2788005 SCOPUS ID: 2-s2.0-70449627028 10/16/2009       25 Citations
  • Mechanism of antiseizure effect of isoflurane in the immature rat hippocampus. (Isaeva EV) Fiziol Zh 2009;55(1):57-60 PMID: 19441716 SCOPUS ID: 2-s2.0-67650273288 05/16/2009       2 Citations
  • Effects of isoflurane on hippocampal seizures at immature rats in vivo. (Isaeva EV) Fiziol Zh 2008;54(5):40-5 PMID: 19058511 SCOPUS ID: 2-s2.0-58149335394 12/09/2008       3 Citations
  • Anesthetic and postanesthetic effects of isoflurane on neuronal activity in the rat hippocampus (Isaeva E, Isaev D, Holmes GL) Neurophysiology 2007;39(4-5):325-326 SCOPUS ID: 2-s2.0-73449100494 12/01/2007    
  • Role of extracellular sialic acid in regulation of neuronal and network excitability in the rat hippocampus. (Isaev D, Isaeva E, Shatskih T, Zhao Q, Smits NC, Shworak NW, Khazipov R, Holmes GL) J Neurosci 2007 Oct 24;27(43):11587-94 PMID: 17959801 PMCID: PMC6673228 SCOPUS ID: 2-s2.0-35548931238 10/26/2007       55 Citations
  • Shunting and hyperpolarizing GABAergic inhibition in the high-potassium model of ictogenesis in the developing rat hippocampus. (Isaev D, Isaeva E, Khazipov R, Holmes GL) Hippocampus 2007;17(3):210-9 PMID: 17294460 SCOPUS ID: 2-s2.0-33947205685 02/13/2007       19 Citations
  • Selective impairment of GABAergic synaptic transmission in the flurothyl model of neonatal seizures. (Isaeva E, Isaev D, Khazipov R, Holmes GL) Eur J Neurosci 2006 Mar;23(6):1559-66 PMID: 16553619 SCOPUS ID: 2-s2.0-33645100228 03/24/2006       49 Citations
  • Anticonvulsant action of GABA in the high potassium-low magnesium model of ictogenesis in the neonatal rat hippocampus in vivo and in vitro. (Isaev D, Isaeva E, Khazipov R, Holmes GL) J Neurophysiol 2005 Oct;94(4):2987-92 PMID: 16000527 SCOPUS ID: 2-s2.0-24944535227 07/08/2005       31 Citations
  • Mitochondrial redox state and Ca2+ sparks in permeabilized mammalian skeletal muscle. (Isaeva EV, Shkryl VM, Shirokova N) J Physiol 2005 Jun 15;565(Pt 3):855-72 PMID: 15845582 PMCID: PMC1464560 SCOPUS ID: 2-s2.0-21344464962 04/23/2005       73 Citations
  • Metabolic regulation of Ca2+ release in permeabilized mammalian skeletal muscle fibres. (Isaeva EV, Shirokova N) J Physiol 2003 Mar 01;547(Pt 2):453-62 PMID: 12562922 PMCID: PMC2342647 SCOPUS ID: 2-s2.0-0037337898 02/04/2003       48 Citations
  • Involvement of different types of Ca2+ currents in the control of the efficiency of inhibitory synaptic transmission between cultured hippocampal neurons (Fedulova SA, Isaeva EV, Veselovsky NS) Neurophysiology 2000;32(6):355-359 SCOPUS ID: 2-s2.0-0034436306 12/01/2000    
  • Possibility of multiquantal transmission at single inhibitory synapse in cultured rat hippocampal neurons. (Fedulova SA, Vasilyev DV, Isaeva EV, Romanyuk SG, Veselovsky NS) Neuroscience 1999;92(4):1217-30 PMID: 10426479 SCOPUS ID: 2-s2.0-0033048293 07/30/1999       39 Citations
  • Effect of nifedipine in high concentrations on inhibitory synaptic transmission (Isaeva EV) Neurophysiology January/February 1999;31(1):53-55 SCOPUS ID: 2-s2.0-27344454011 01/01/1999       1 Citation
  • Evoked inhibitory postsynaptic currents in the dynamics of development of cultured hippocampal neurons of rats (Isaeva EV, Sidorenko VG, Fedulova SA, Veselovskii NS) Neurophysiology September/October 1999;31(5):304-309 SCOPUS ID: 2-s2.0-0033360949 01/01/1999       2 Citations
  • Potassium channel blocker-induced presynaptic modulation of inhibitory synaptic transmission in hippocampal neurons of rats (Vasil'yev DV, Isaeva EV, Fedulova SA, Veselovskii NS) Neurophysiology July/October 1998;30(4-5):275-278 SCOPUS ID: 2-s2.0-33750127190 01/01/1998    
  • Voltage-dependent calcium channels in cultivated neurons of the rat hippocampus (Isaeva EV, Fedulova SA, Veselovskii NS) Neurophysiology July/October 1998;30(4-5):297-300 SCOPUS ID: 2-s2.0-33749502238 01/01/1998       4 Citations
    • Last update: 02/21/2022