Medical College of Wisconsin
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Yi-Guang Chen PhD

Yi-Guang Chen PhD

Associate Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Endocrinology


  • Interferon gamma Limits Diabetogenic CD8 T-Cell Effector Responses in Type-1 Diabetes. (Driver JP, Racine JJ, Ye C, Lamont DJ, Newby BN, McPhee-Leeth CG, Chapman HD, Brusko TM, Chen YG, Mathews CE, Serreze DV) Diabetes 2016 Dec 05 PMID: 27920091 12/07/2016
  • Congenic mapping identifies a novel Idd9 subregion regulating type 1 diabetes in NOD mice. (Lin B, Ciecko AE, MacKinney E, Serreze DV, Chen YG) Immunogenetics 2017 Mar;69(3):193-198 PMID: 27796442 11/01/2016
  • Interleukin-15-mediated inflammation promotes non-alcoholic fatty liver disease. (Cepero-Donates Y, Lacraz G, Ghobadi F, Rakotoarivelo V, Orkhis S, Mayhue M, Chen YG, Rola-Pleszczynski M, Menendez A, Ilangumaran S, Ramanathan S) Cytokine 2016 Jun;82:102-11 PMID: 26868085 02/13/2016
  • Repeated Activation of Lung Invariant NKT Cells Results in Chronic Obstructive Pulmonary Disease-Like Symptoms. (Tsao CC, Tsao PN, Chen YG, Chuang YH) PLoS One 2016;11(1):e0147710 PMID: 26811900 PMCID: PMC4727802 01/27/2016
  • Homeostasis of IL-15 dependent lymphocyte subsets in the liver. (Cepero-Donates Y, Rakotoarivelo V, Mayhue M, Ma A, Chen YG, Ramanathan S) Cytokine 2016 Jun;82:95-101 PMID: 26778709 PMCID: PMC5293139 01/19/2016
  • Blood-based signatures in type 1 diabetes. (Cabrera SM, Chen YG, Hagopian WA, Hessner MJ) Diabetologia 2016 Mar;59(3):414-25 PMID: 26699650 PMCID: PMC4744128 12/25/2015
  • Interleukin-1 antagonism moderates the inflammatory state associated with Type 1 diabetes during clinical trials conducted at disease onset. (Cabrera SM, Wang X, Chen YG, Jia S, Kaldunski ML, Greenbaum CJ, Type 1 Diabetes TrialNet Canakinumab Study Group, Mandrup-Poulsen T, AIDA Study Group, Hessner MJ) Eur J Immunol 2016 Apr;46(4):1030-46 PMID: 26692253 PMCID: PMC4828314 12/23/2015
  • The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scid Mice. (Presa M, Chen YG, Grier AE, Leiter EH, Brehm MA, Greiner DL, Shultz LD, Serreze DV) J Immunol 2015 Oct 01;195(7):3011-9 PMID: 26283479 PMCID: PMC4575869 08/19/2015
  • Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease. (Qin W, Dion SL, Kutny PM, Zhang Y, Cheng AW, Jillette NL, Malhotra A, Geurts AM, Chen YG, Wang H) Genetics 2015 Jun;200(2):423-30 PMID: 25819794 PMCID: PMC4492369 03/31/2015
  • A locus on mouse chromosome 13 inversely regulates CD1d expression and the development of invariant natural killer T-cells. (Tsaih SW, Presa M, Khaja S, Ciecko AE, Serreze DV, Chen YG) Genes Immun 2015 Apr-May;16(3):221-30 PMID: 25654212 PMCID: PMC4409484 02/06/2015
  • Molecular signatures differentiate immune states in type 1 diabetic families. (Chen YG, Cabrera SM, Jia S, Kaldunski ML, Kramer J, Cheong S, Geoffrey R, Roethle MF, Woodliff JE, Greenbaum CJ, Wang X, Hessner MJ) Diabetes 2014 Nov;63(11):3960-73 PMID: 24760139 PMCID: PMC4207392 04/25/2014
  • Gene targeting in NOD mouse embryos using zinc-finger nucleases. (Chen YG, Forsberg MH, Khaja S, Ciecko AE, Hessner MJ, Geurts AM) Diabetes 2014 Jan;63(1):68-74 PMID: 23974926 PMCID: PMC3868049 08/27/2013
  • Temporal induction of immunoregulatory processes coincides with age-dependent resistance to viral-induced type 1 diabetes. (Chen YG, Mordes JP, Blankenhorn EP, Kashmiri H, Kaldunski ML, Jia S, Geoffrey R, Wang X, Hessner MJ) Genes Immun 2013 Sep;14(6):387-400 PMID: 23739610 PMCID: PMC4027975 06/07/2013
  • Genetic control of murine invariant natural killer T cells maps to multiple type 1 diabetes regions. (Tsaih SW, Khaja S, Ciecko AE, MacKinney E, Chen YG) Genes Immun 2013 Sep;14(6):380-6 PMID: 23719031 PMCID: PMC3766462 05/31/2013
  • Biobreeding rat islets exhibit reduced antioxidative defense and N-acetyl cysteine treatment delays type 1 diabetes. (Bogdani M, Henschel AM, Kansra S, Fuller JM, Geoffrey R, Jia S, Kaldunski ML, Pavletich S, Prosser S, Chen YG, Lernmark A, Hessner MJ) J Endocrinol 2013 Feb;216(2):111-23 PMID: 23111281 PMCID: PMC4077722 11/01/2012
  • Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse. (Bobbala D, Chen XL, Leblanc C, Mayhue M, Stankova J, Tanaka T, Chen YG, Ilangumaran S, Ramanathan S) Diabetologia 2012 Nov;55(11):3010-20 PMID: 22890824 08/15/2012
  • Subcongenic analyses reveal complex interactions between distal chromosome 4 genes controlling diabetogenic B cells and CD4 T cells in nonobese diabetic mice. (Stolp J, Chen YG, Cox SL, Henck V, Zhang W, Tsaih SW, Chapman H, Stearns T, Serreze DV, Silveira PA) J Immunol 2012 Aug 01;189(3):1406-17 PMID: 22732593 PMCID: PMC3401322 06/27/2012
  • Comparative genetics: synergizing human and NOD mouse studies for identifying genetic causation of type 1 diabetes. (Driver JP, Chen YG, Mathews CE) Rev Diabet Stud 2012;9(4):169-87 PMID: 23804259 PMCID: PMC3740689 01/01/2012
  • Genetic control of murine invariant natural killer T-cell development dynamically differs dependent on the examined tissue type. (Chen YG, Tsaih SW, Serreze DV) Genes Immun 2012 Feb;13(2):164-74 PMID: 21938016 PMCID: PMC3291802 09/23/2011
  • Testing the role of P2X7 receptors in the development of type 1 diabetes in nonobese diabetic mice. (Chen YG, Scheuplein F, Driver JP, Hewes AA, Reifsnyder PC, Leiter EH, Serreze DV) J Immunol 2011 Apr 01;186(7):4278-84 PMID: 21357538 PMCID: PMC3094905 03/02/2011
  • Unmasking genes in a type 1 diabetes-resistant mouse strain that enhances pathogenic CD8 T-cell responses. (Driver JP, Chen YG, Zhang W, Asrat S, Serreze DV) Diabetes 2011 Apr;60(4):1354-9 PMID: 21307079 PMCID: PMC3064110 02/11/2011
  • Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease. (Driver JP, Serreze DV, Chen YG) Semin Immunopathol 2011 Jan;33(1):67-87 PMID: 20424843 04/29/2010
  • Invariant natural killer T-cell control of type 1 diabetes: a dendritic cell genetic decision of a silver bullet or Russian roulette. (Driver JP, Scheuplein F, Chen YG, Grier AE, Wilson SB, Serreze DV) Diabetes 2010 Feb;59(2):423-32 PMID: 19903740 PMCID: PMC2809954 11/12/2009
  • A recombinant heavy chain antibody approach blocks ART2 mediated deletion of an iNKT cell population that upon activation inhibits autoimmune diabetes. (Scheuplein F, Rissiek B, Driver JP, Chen YG, Koch-Nolte F, Serreze DV) J Autoimmun 2010 Mar;34(2):145-54 PMID: 19796917 PMCID: PMC2822066 10/03/2009
  • Idd9/11 genetic locus regulates diabetogenic activity of CD4 T-cells in nonobese diabetic (NOD) mice. (Chen YG, Scheuplein F, Osborne MA, Tsaih SW, Chapman HD, Serreze DV) Diabetes 2008 Dec;57(12):3273-80 PMID: 18776136 PMCID: PMC2584133 09/09/2008
  • Selective delivery of beta cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in NOD mice. (Mukhopadhaya A, Hanafusa T, Jarchum I, Chen YG, Iwai Y, Serreze DV, Steinman RM, Tarbell KV, DiLorenzo TP) Proc Natl Acad Sci U S A 2008 Apr 29;105(17):6374-9 PMID: 18430797 PMCID: PMC2359791 04/24/2008
  • Subcongenic analysis of genetic basis for impaired development of invariant NKT cells in NOD mice. (Chen YG, Driver JP, Silveira PA, Serreze DV) Immunogenetics 2007 Sep;59(9):705-12 PMID: 17619875 07/11/2007
  • Cellular expression requirements for inhibition of type 1 diabetes by a dominantly protective major histocompatibility complex haplotype. (Chen YG, Silveira PA, Osborne MA, Chapman HD, Serreze DV) Diabetes 2007 Feb;56(2):424-30 PMID: 17259387 01/30/2007
  • Partial versus full allogeneic hemopoietic chimerization is a preferential means to inhibit type 1 diabetes as the latter induces generalized immunosuppression. (Serreze DV, Osborne MA, Chen YG, Chapman HD, Pearson T, Brehm MA, Greiner DL) J Immunol 2006 Nov 15;177(10):6675-84 PMID: 17082580 11/04/2006
  • CD38 is required for the peripheral survival of immunotolerogenic CD4+ invariant NK T cells in nonobese diabetic mice. (Chen YG, Chen J, Osborne MA, Chapman HD, Besra GS, Porcelli SA, Leiter EH, Wilson SB, Serreze DV) J Immunol 2006 Sep 01;177(5):2939-47 PMID: 16920929 08/22/2006
  • Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion. (Chen J, Chen YG, Reifsnyder PC, Schott WH, Lee CH, Osborne M, Scheuplein F, Haag F, Koch-Nolte F, Serreze DV, Leiter EH) J Immunol 2006 Apr 15;176(8):4590-9 PMID: 16585549 04/06/2006
  • Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: II. Immunologic analysis. (Lee CH, Chen YG, Chen J, Reifsnyder PC, Serreze DV, Clare-Salzler M, Rodriguez M, Wasserfall C, Atkinson MA, Leiter EH) Diabetes 2006 Jan;55(1):171-8 PMID: 16380490 12/29/2005
  • Of mice and men: use of animal models to identify possible interventions for the prevention of autoimmune type 1 diabetes in humans. (Serreze DV, Chen YG) Trends Immunol 2005 Nov;26(11):603-7 PMID: 16140038 09/06/2005
  • Activated NKT cells inhibit autoimmune diabetes through tolerogenic recruitment of dendritic cells to pancreatic lymph nodes. (Chen YG, Choisy-Rossi CM, Holl TM, Chapman HD, Besra GS, Porcelli SA, Shaffer DJ, Roopenian D, Wilson SB, Serreze DV) J Immunol 2005 Feb 01;174(3):1196-204 PMID: 15661873 01/22/2005
  • Molecular cloning and sequencing of the human heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase from bone marrow culture. (Omasa T, Chen YG, Mantalaris A, Tsai YC, Wu JH) DNA Seq 2002 Jun;13(3):133-7 PMID: 12391722 10/24/2002
  • A cDNA from human bone marrow encoding a protein exhibiting homology to the ATP1gamma1/PLM/MAT8 family of transmembrane proteins. (Omasa T, Chen YG, Mantalaris A, Wu JH) Biochim Biophys Acta 2001 Jan 26;1517(2):307-10 PMID: 11342114 05/09/2001
  • Expression of mPer1 and mPer2, two mammalian clock genes, in murine bone marrow. (Chen YG, Mantalaris A, Bourne P, Keng P, Wu JH) Biochem Biophys Res Commun 2000 Sep 24;276(2):724-8 PMID: 11027538 10/12/2000
  • Preparation of Der p 1 specific monoclonal antibodies and use in a two-site-ELISA to detect Der p 1 allergen. (Chien TI, Chen YG, Chiang BL) J Microbiol Immunol Infect 2000 Jun;33(2):87-92 PMID: 10917877 08/05/2000
  • Characterization of monoclonal antibodies against hepatitis C virus nonstructural protein 3: different antigenic determinants from human B cells. (Ou-Yang P, Chiang BL, Hwang LH, Chen YG, Yang PM, Chi WK, Chen PJ, Chen DS) J Med Virol 1999 Apr;57(4):345-50 PMID: 10089044 03/24/1999
  • Last update: 01/03/2017
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