Medical College of Wisconsin
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Demin Wang PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Microbiology and Immunology

Member of the Cancer Center


  • PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development. (Yu M, Chen Y, Zeng H, Zheng Y, Fu G, Zhu W, Broeckel U, Aggarwal P, Turner A, Neale G, Guy C, Zhu N, Chi H, Wen R, Wang D) Nat Commun 2017 11 13;8(1):1457 PMID: 29133930 PMCID: PMC5684131 11/15/2017       2 Citations
  • IVIg for Treatment of Severe Refractory Heparin-Induced Thrombocytopenia. (Padmanabhan A, Jones CG, Pechauer SM, Curtis BR, Bougie DW, Irani MS, Bryant BJ, Alperin JB, Deloughery TG, Mulvey KP, Dhakal B, Wen R, Wang D, Aster RH) Chest 2017 09;152(3):478-485 PMID: 28427966 PMCID: PMC5812774 04/22/2017       18 Citations
  • Phospholipase Cγ1 is required for pre-TCR signal transduction and pre-T cell development. (Fu G, Yu M, Chen Y, Zheng Y, Zhu W, Newman DK, Wang D, Wen R) Eur J Immunol 2017 01;47(1):74-83 PMID: 27759161 PMCID: PMC5559087 10/21/2016    
  • A Novel PF4-Dependent Platelet Activation Assay Identifies Patients Likely to Have Heparin-Induced Thrombocytopenia/Thrombosis. (Padmanabhan A, Jones CG, Curtis BR, Bougie DW, Sullivan MJ, Peswani N, McFarland JG, Eastwood D, Wang D, Aster RH) Chest 2016 09;150(3):506-15 PMID: 26905366 PMCID: PMC5028397 02/26/2016       18 Citations
  • Kras Is Critical for B Cell Lymphopoiesis. (Chen Y, Zheng Y, You X, Yu M, Fu G, Su X, Zhou F, Zhu W, Wu Z, Zhang J, Wen R, Wang D) J Immunol 2016 Feb 15;196(4):1678-85 PMID: 26773157 PMCID: PMC4744498 01/17/2016       4 Citations
  • R-Ras Regulates Murine T Cell Migration and Intercellular Adhesion Molecule-1 Binding. (Yan X, Yan M, Guo Y, Singh G, Chen Y, Yu M, Wang D, Hillery CA, Chan AM) PLoS One 2015;10(12):e0145218 PMID: 26710069 PMCID: PMC4692399 12/29/2015       3 Citations
  • A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control. (Xin G, Schauder DM, Lainez B, Weinstein JS, Dai Z, Chen Y, Esplugues E, Wen R, Wang D, Parish IA, Zajac AJ, Craft J, Cui W) Cell Rep 2015 Nov 10;13(6):1118-1124 PMID: 26527008 PMCID: PMC4859432 11/04/2015       18 Citations
  • Restoration of responsiveness of phospholipase Cγ2-deficient platelets by enforced expression of phospholipase Cγ1. (Zheng Y, Adams T, Zhi H, Yu M, Wen R, Newman PJ, Wang D, Newman DK) PLoS One 2015;10(3):e0119739 PMID: 25793864 PMCID: PMC4368822 03/21/2015       5 Citations
  • Critical role of CD4 T cells in PF4/heparin antibody production in mice. (Zheng Y, Yu M, Padmanabhan A, Aster RH, Yuan L, Wen R, Wang D) Blood 2015 Mar 12;125(11):1826-9 PMID: 25595736 PMCID: PMC4357587 01/18/2015       10 Citations
  • Heparin-independent, PF4-dependent binding of HIT antibodies to platelets: implications for HIT pathogenesis. (Padmanabhan A, Jones CG, Bougie DW, Curtis BR, McFarland JG, Wang D, Aster RH) Blood 2015 Jan 01;125(1):155-61 PMID: 25342714 PMCID: PMC4281824 10/25/2014       31 Citations
  • B-cell tolerance regulates production of antibodies causing heparin-induced thrombocytopenia. (Zheng Y, Wang AW, Yu M, Padmanabhan A, Tourdot BE, Newman DK, White GC, Aster RH, Wen R, Wang D) Blood 2014 Feb 06;123(6):931-4 PMID: 24357731 PMCID: PMC3916881 12/21/2013       16 Citations
  • Critical role for mouse marginal zone B cells in PF4/heparin antibody production. (Zheng Y, Yu M, Podd A, Yuan L, Newman DK, Wen R, Arepally G, Wang D) Blood 2013 Apr 25;121(17):3484-92 PMID: 23460609 PMCID: PMC3637017 03/06/2013       22 Citations
  • Critical role of B cell lymphoma 10 in BAFF-regulated NF-κB activation and survival of anergic B cells. (Yu M, Chen Y, He Y, Podd A, Fu G, Wright JA, Kleiman E, Khan WN, Wen R, Wang D) J Immunol 2012 Dec 01;189(11):5185-93 PMID: 23087406 PMCID: PMC3786778 10/23/2012       9 Citations
  • Phospholipase Cγ2 plays a role in TCR signal transduction and T cell selection. (Fu G, Chen Y, Schuman J, Wang D, Wen R) J Immunol 2012 Sep 01;189(5):2326-32 PMID: 22837484 PMCID: PMC3528184 07/28/2012       9 Citations
  • SU-E-J-11: Characterization of Interfractioanal Anatomical Variations in Post-Operative Radiation Therapy for Prostate Bed. (Liu F, Ahunbay E, Christian R, Lawton C, Wang D, Li X) Med Phys 2012 Jun;39(6Part6):3654 PMID: 28517560 06/01/2012    
  • Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells. (Chen Y, Yu M, Dai X, Zogg M, Wen R, Weiler H, Wang D) J Exp Med 2011 May 09;208(5):923-35 PMID: 21502331 PMCID: PMC3092340 04/20/2011       23 Citations
  • Nuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation. (Wuerzberger-Davis SM, Chen Y, Yang DT, Kearns JD, Bates PW, Lynch C, Ladell NC, Yu M, Podd A, Zeng H, Huang TT, Wen R, Hoffmann A, Wang D, Miyamoto S) Immunity 2011 Feb 25;34(2):188-200 PMID: 21333553 PMCID: PMC3111750 02/22/2011       4 Citations
  • The role of NF-kappaB and Smad3 in TGF-beta-mediated Foxp3 expression. (Jana S, Jailwala P, Haribhai D, Waukau J, Glisic S, Grossman W, Mishra M, Wen R, Wang D, Williams CB, Ghosh S) Eur J Immunol 2009 Sep;39(9):2571-83 PMID: 19701891 08/25/2009       37 Citations
  • A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation. (Schuman J, Chen Y, Podd A, Yu M, Liu HH, Wen R, Chen ZJ, Wang D) Blood 2009 May 07;113(19):4566-74 PMID: 19196865 PMCID: PMC2680363 02/07/2009       50 Citations
  • Bcl10 plays a divergent role in NK cell-mediated cytotoxicity and cytokine generation. (Malarkannan S, Regunathan J, Chu H, Kutlesa S, Chen Y, Zeng H, Wen R, Wang D) J Immunol 2007 Sep 15;179(6):3752-62 PMID: 17785812 09/06/2007       33 Citations
  • Last update: 08/02/2014
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