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Ivor J. Benjamin MD

Ivor J. Benjamin MD

Center Director, Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Cardiology
Program: Administration

Member of the Cancer Center
Member of the Cardiovascular Center


  • Why publish in the American Journal of Physiology-Heart and Circulatory Physiology? (Zucker IH, Lindsey ML, Delmar M, De Windt LJ, Des Rosiers C, Diz DI, Hester RL, Jones SP, Kanagy NL, Kitakaze M, Liao R, Lopaschuk GD, Patel KP, Recchia FA, Sadoshima J, Shah AM, Ungvari Z, Benjamin IJ, Blaustein MP, Charkoudian N, Efimov IR, Gutterman D, Kass DA, Liao Y, O'Leary DS, Ripplinger CM, Wolin MS) Am J Physiol Heart Circ Physiol 2017 Aug 01;313(2):H221-H223 PMID: 28626081 06/20/2017
  • Genomic Approaches to Hypertension. (Dodoo SN, Benjamin IJ) Cardiol Clin 2017 May;35(2):185-196 PMID: 28411893 04/17/2017
  • The growing world of small heat shock proteins: from structure to functions. (Carra S, Alberti S, Arrigo PA, Benesch JL, Benjamin IJ, Boelens W, Bartelt-Kirbach B, Brundel BJJM, Buchner J, Bukau B, Carver JA, Ecroyd H, Emanuelsson C, Finet S, Golenhofen N, Goloubinoff P, Gusev N, Haslbeck M, Hightower LE, Kampinga HH, Klevit RE, Liberek K, Mchaourab HS, McMenimen KA, Poletti A, Quinlan R, Strelkov SV, Toth ME, Vierling E, Tanguay RM) Cell Stress Chaperones 2017 Jul;22(4):601-611 PMID: 28364346 PMCID: PMC5465036 04/02/2017
  • Efficient Precision Genome Editing in iPSCs via Genetic Co-targeting with Selection. (Mitzelfelt KA, McDermott-Roe C, Grzybowski MN, Marquez M, Kuo CT, Riedel M, Lai S, Choi MJ, Kolander KD, Helbling D, Dimmock DP, Battle MA, Jou CJ, Tristani-Firouzi M, Verbsky JW, Benjamin IJ, Geurts AM) Stem Cell Reports 2017 Mar 14;8(3):491-499 PMID: 28238794 PMCID: PMC5355643 02/28/2017
  • Perspectives from NHLBI Global Health Think Tank Meeting for Late Stage (T4) Translation Research. (Engelgau MM, Peprah E, Sampson UK, Mishoe H, Benjamin IJ, Douglas PS, Hochman JS, Ridker PM, Brandes N, Checkley W, El-Saharty S, Ezzati M, Hennis A, Jiang L, Krumholz HM, Lamourelle G, Makani J, Narayan KM, Ohene-Frempong K, Straus SE, Stuckler D, Chambers DA, Belis D, Bennett GC, Boyington JE, Creazzo TL, de Jesus JM, Krishnamurti C, Lowden MR, Punturieri A, Shero ST, Young NS, Zou S, Mensah GA) Glob Heart 2016 Jul 21 PMID: 27452772 07/28/2016
  • Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases. (Dayalan Naidu S, Sutherland C, Zhang Y, Risco A, de la Vega L, Caunt CJ, Hastie CJ, Lamont DJ, Torrente L, Chowdhry S, Benjamin IJ, Keyse SM, Cuenda A, Dinkova-Kostova AT) Mol Cell Biol 2016 Sep 15;36(18):2403-17 PMID: 27354066 PMCID: PMC5007788 06/30/2016
  • The Human 343delT HSPB5 Chaperone Associated with Early-onset Skeletal Myopathy Causes Defects in Protein Solubility. (Mitzelfelt KA, Limphong P, Choi MJ, Kondrat FD, Lai S, Kolander KD, Kwok WM, Dai Q, Grzybowski MN, Zhang H, Taylor GM, Lui Q, Thao MT, Hudson JA, Barresi R, Bushby K, Jungbluth H, Wraige E, Geurts AM, Benesch JL, Riedel M, Christians ES, Minella AC, Benjamin IJ) J Biol Chem 2016 07 15;291(29):14939-53 PMID: 27226619 PMCID: PMC4946913 05/27/2016
  • HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth. (Su KH, Cao J, Tang Z, Dai S, He Y, Sampson SB, Benjamin IJ, Dai C) Nat Cell Biol 2016 May;18(5):527-39 PMID: 27043084 PMCID: PMC5341796 04/05/2016
  • Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome. (Grose JH, Langston K, Wang X, Squires S, Mustafi SB, Hayes W, Neubert J, Fischer SK, Fasano M, Saunders GM, Dai Q, Christians E, Lewandowski ED, Ping P, Benjamin IJ) PLoS One 2015;10(10):e0133994 PMID: 26465331 PMCID: PMC4605610 10/16/2015
  • Rescue of αB Crystallin (HSPB5) Mutants Associated Protein Aggregation by Co-Expression of HSPB5 Partners. (Hussein RM, Benjamin IJ, Kampinga HH) PLoS One 2015;10(5):e0126761 PMID: 25961584 PMCID: PMC4427338 05/12/2015
  • A near-infrared fluorescent voltage-sensitive dye allows for moderate-throughput electrophysiological analyses of human induced pluripotent stem cell-derived cardiomyocytes. (Lopez-Izquierdo A, Warren M, Riedel M, Cho S, Lai S, Lux RL, Spitzer KW, Benjamin IJ, Tristani-Firouzi M, Jou CJ) Am J Physiol Heart Circ Physiol 2014 Nov 01;307(9):H1370-7 PMID: 25172899 PMCID: PMC4217013 08/31/2014
  • Functional and pharmacological analysis of cardiomyocytes differentiated from human peripheral blood mononuclear-derived pluripotent stem cells. (Riedel M, Jou CJ, Lai S, Lux RL, Moreno AP, Spitzer KW, Christians E, Tristani-Firouzi M, Benjamin IJ) Stem Cell Reports 2014 Jul 08;3(1):131-41 PMID: 25068127 PMCID: PMC4110777 07/30/2014
  • A near-infrared fluorescent voltage-sensitive dye allows for moderate-throughput analyses of human induced pluripotent stem cell-derived cardiomyocytes (Angelica Lopez-Izquierdo, Mark Warren, Michael Reidel, Scott Cho, Shuping Lai, Robert Lux, Kenneth Spitzer, Ivor Benjamin, Martin Tristani-Firouzi, and Chuanchau Jou) American Journal of Physiology - Heart and Circulatory Physiology 05/20/2014
  • Chaperones and cardiac misfolding protein diseases. (Christians ES, Mustafi SB, Benjamin IJ) Curr Protein Pept Sci 2014 May;15(3):189-204 PMID: 24694370 04/04/2014
  • Molecular stress-inducing compounds increase osteoclast formation in a heat shock factor 1 protein-dependent manner. (Chai RC, Kouspou MM, Lang BJ, Nguyen CH, van der Kraan AG, Vieusseux JL, Lim RC, Gillespie MT, Benjamin IJ, Quinn JM, Price JT) J Biol Chem 2014 May 09;289(19):13602-14 PMID: 24692538 PMCID: PMC4036365 04/03/2014
  • Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation. (Zhang Y, Dayalan Naidu S, Samarasinghe K, Van Hecke GC, Pheely A, Boronina TN, Cole RN, Benjamin IJ, Cole PA, Ahn YH, Dinkova-Kostova AT) Br J Cancer 2014 Jan 07;110(1):71-82 PMID: 24322890 PMCID: PMC3887302 12/11/2013
  • Aggregate-prone R120GCRYAB triggers multifaceted modifications of the thioredoxin system. (Banerjee Mustafi S, Grose JH, Zhang H, Pratt GW, Sadoshima J, Christians ES, Benjamin IJ) Antioxid Redox Signal 2014 Jun 20;20(18):2891-906 PMID: 24180415 PMCID: PMC4039002 11/05/2013
  • Malfolded protein structure and proteostasis in lung diseases. (Balch WE, Sznajder JI, Budinger S, Finley D, Laposky AD, Cuervo AM, Benjamin IJ, Barreiro E, Morimoto RI, Postow L, Weissman AM, Gail D, Banks-Schlegel S, Croxton T, Gan W) Am J Respir Crit Care Med 2014 Jan 01;189(1):96-103 PMID: 24033344 PMCID: PMC3919126 09/17/2013
  • Effects of redox state on the efficient uptake of cell permeable Peptide in Mammalian cells. (Squires S, Christians E, Riedel M, Timothy D, Rodesch CK, Marvin J, Benjamin I) Open Biochem J 2013;7:54-65 PMID: 23919090 PMCID: PMC3731798 08/07/2013
  • The NADPH metabolic network regulates human αB-crystallin cardiomyopathy and reductive stress in Drosophila melanogaster. (Xie HB, Cammarato A, Rajasekaran NS, Zhang H, Suggs JA, Lin HC, Bernstein SI, Benjamin IJ, Golic KG) PLoS Genet 2013 Jun;9(6):e1003544 PMID: 23818860 PMCID: PMC3688542 07/03/2013
  • Modeling human protein aggregation cardiomyopathy using murine induced pluripotent stem cells. (Limphong P, Zhang H, Christians E, Liu Q, Riedel M, Ivey K, Cheng P, Mitzelfelt K, Taylor G, Winge D, Srivastava D, Benjamin I) Stem Cells Transl Med 2013 Mar;2(3):161-6 PMID: 23430692 PMCID: PMC3659767 02/23/2013
  • Reductive stress linked to small HSPs, G6PD, and Nrf2 pathways in heart disease. (Brewer AC, Mustafi SB, Murray TV, Rajasekaran NS, Benjamin IJ) Antioxid Redox Signal 2013 Mar 20;18(9):1114-27 PMID: 22938199 PMCID: PMC3567781 09/04/2012
  • HSPB2 is dispensable for the cardiac hypertrophic response but reduces mitochondrial energetics following pressure overload in mice. (Ishiwata T, Orosz A, Wang X, Mustafi SB, Pratt GW, Christians ES, Boudina S, Abel ED, Benjamin IJ) PLoS One 2012;7(8):e42118 PMID: 22870288 PMCID: PMC3411653 08/08/2012
  • Small heat shock proteins in redox metabolism: implications for cardiovascular diseases. (Christians ES, Ishiwata T, Benjamin IJ) Int J Biochem Cell Biol 2012 Oct;44(10):1632-45 PMID: 22710345 PMCID: PMC3412898 06/20/2012
  • Targeting endoglin, an auxiliary transforming growth factor β coreceptor, to prevent fibrosis and heart failure. (Benjamin IJ) Circulation 2012 Jun 05;125(22):2689-91 PMID: 22592899 PMCID: PMC3401168 05/18/2012
  • Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR. (Gabai VL, Meng L, Kim G, Mills TA, Benjamin IJ, Sherman MY) Mol Cell Biol 2012 Mar;32(5):929-40 PMID: 22215620 PMCID: PMC3295200 01/05/2012
  • Glutathione-dependent reductive stress triggers mitochondrial oxidation and cytotoxicity. (Zhang H, Limphong P, Pieper J, Liu Q, Rodesch CK, Christians E, Benjamin IJ) FASEB J 2012 Apr;26(4):1442-51 PMID: 22202674 PMCID: PMC3316899 12/29/2011
  • HSF1-dependent upregulation of Hsp70 by sulfhydryl-reactive inducers of the KEAP1/NRF2/ARE pathway. (Zhang Y, Ahn YH, Benjamin IJ, Honda T, Hicks RJ, Calabrese V, Cole PA, Dinkova-Kostova AT) Chem Biol 2011 Nov 23;18(11):1355-61 PMID: 22118669 PMCID: PMC3302153 11/29/2011
  • Proteostasis and REDOX state in the heart. (Christians ES, Benjamin IJ) Am J Physiol Heart Circ Physiol 2012 Jan 01;302(1):H24-37 PMID: 22003057 PMCID: PMC3334238 10/18/2011
  • Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice. (Rajasekaran NS, Varadharaj S, Khanderao GD, Davidson CJ, Kannan S, Firpo MA, Zweier JL, Benjamin IJ) Antioxid Redox Signal 2011 Mar 15;14(6):957-71 PMID: 21126175 PMCID: PMC3113450 12/04/2010
  • Selective degradation of aggregate-prone CryAB mutants by HSPB1 is mediated by ubiquitin-proteasome pathways. (Zhang H, Rajasekaran NS, Orosz A, Xiao X, Rechsteiner M, Benjamin IJ) J Mol Cell Cardiol 2010 Dec;49(6):918-30 PMID: 20863832 PMCID: PMC2975794 09/25/2010
  • Involvement of reductive stress in the cardiomyopathy in transgenic mice with cardiac-specific overexpression of heat shock protein 27. (Zhang X, Min X, Li C, Benjamin IJ, Qian B, Zhang X, Ding Z, Gao X, Yao Y, Ma Y, Cheng Y, Liu L) Hypertension 2010 Jun;55(6):1412-7 PMID: 20439823 05/05/2010
  • Febrile-range temperature modifies cytokine gene expression in LPS-stimulated macrophages by differentially modifying NF-{kappa}B recruitment to cytokine gene promoters. (Cooper ZA, Ghosh A, Gupta A, Maity T, Benjamin IJ, Vogel SN, Hasday JD, Singh IS) Am J Physiol Cell Physiol 2010 Jan;298(1):C171-81 PMID: 19846753 PMCID: PMC2806152 10/23/2009
  • Reductive stress on life span extension in C. elegans. (Ralser M, Benjamin IJ) BMC Res Notes 2008 Jun 04;1:19 PMID: 18710529 PMCID: PMC2518267 08/20/2008
  • Global expression profiling identifies a novel biosignature for protein aggregation R120GCryAB cardiomyopathy in mice. (Rajasekaran NS, Firpo MA, Milash BA, Weiss RB, Benjamin IJ) Physiol Genomics 2008 Oct 08;35(2):165-72 PMID: 18628338 PMCID: PMC2575954 07/17/2008
  • Autophagy is an adaptive response in desmin-related cardiomyopathy. (Tannous P, Zhu H, Johnstone JL, Shelton JM, Rajasekaran NS, Benjamin IJ, Nguyen L, Gerard RD, Levine B, Rothermel BA, Hill JA) Proc Natl Acad Sci U S A 2008 Jul 15;105(28):9745-50 PMID: 18621691 PMCID: PMC2474535 07/16/2008
  • Heat shock co-activates interleukin-8 transcription. (Singh IS, Gupta A, Nagarsekar A, Cooper Z, Manka C, Hester L, Benjamin IJ, He JR, Hasday JD) Am J Respir Cell Mol Biol 2008 Aug;39(2):235-42 PMID: 18367728 PMCID: PMC2542457 03/28/2008
  • Differential display of DNA-binding proteins reveals heat-shock factor 1 as a circadian transcription factor. (Reinke H, Saini C, Fleury-Olela F, Dibner C, Benjamin IJ, Schibler U) Genes Dev 2008 Feb 01;22(3):331-45 PMID: 18245447 PMCID: PMC2216693 02/05/2008
  • CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging mice. (Benjamin IJ, Guo Y, Srinivasan S, Boudina S, Taylor RP, Rajasekaran NS, Gottlieb R, Wawrousek EF, Abel ED, Bolli R) Am J Physiol Heart Circ Physiol 2007 Nov;293(5):H3201-9 PMID: 17873008 PMCID: PMC3683980 09/18/2007
  • Unmasking different mechanical and energetic roles for the small heat shock proteins CryAB and HSPB2 using genetically modified mouse hearts. (Pinz I, Robbins J, Rajasekaran NS, Benjamin IJ, Ingwall JS) FASEB J 2008 Jan;22(1):84-92 PMID: 17846079 09/12/2007
  • Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice. (Rajasekaran NS, Connell P, Christians ES, Yan LJ, Taylor RP, Orosz A, Zhang XQ, Stevenson TJ, Peshock RM, Leopold JA, Barry WH, Loscalzo J, Odelberg SJ, Benjamin IJ) Cell 2007 Aug 10;130(3):427-39 PMID: 17693254 PMCID: PMC2962423 08/19/2007
  • Induction of KLF4 in response to heat stress. (Liu Y, Wang J, Yi Y, Zhang H, Liu J, Liu M, Yuan C, Tang D, Benjamin IJ, Xiao X) Cell Stress Chaperones 2006;11(4):379-89 PMID: 17278886 PMCID: PMC1712684 02/07/2007
  • Viewing a stressful episode of ER: is ATF6 the triage nurse? (Benjamin IJ) Circ Res 2006 May 12;98(9):1120-2 PMID: 16690892 05/13/2006
  • CRYAB and HSPB2 deficiency increases myocyte mitochondrial permeability transition and mitochondrial calcium uptake. (Kadono T, Zhang XQ, Srinivasan S, Ishida H, Barry WH, Benjamin IJ) J Mol Cell Cardiol 2006 Jun;40(6):783-9 PMID: 16678848 05/09/2006
  • Heat shock response: lessons from mouse knockouts. (Christians ES, Benjamin IJ) Handb Exp Pharmacol 2006(172):139-52 PMID: 16610358 04/14/2006
  • RANK ligand expression in heat shock factor-2 deficient mouse bone marrow stromal/preosteoblast cells. (Kajiya H, Ito M, Ohshima H, Kenmotsu S, Ries WL, Benjamin IJ, Reddy SV) J Cell Biochem 2006 Apr 15;97(6):1362-9 PMID: 16365894 12/21/2005
  • A murine world without HSFs: meeting report. (Christians E, Benjamin IJ) Cell Stress Chaperones 2005;10(4):265-7 PMID: 16333980 PMCID: PMC1283871 12/13/2005
  • Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38 beta MAPK and heat shock factor-1. (Kim HP, Wang X, Zhang J, Suh GY, Benjamin IJ, Ryter SW, Choi AM) J Immunol 2005 Aug 15;175(4):2622-9 PMID: 16081837 08/06/2005
  • Induction of heat shock proteins by heregulin beta1 leads to protection from apoptosis and anchorage-independent growth. (Khaleque MA, Bharti A, Sawyer D, Gong J, Benjamin IJ, Stevenson MA, Calderwood SK) Oncogene 2005 Sep 29;24(43):6564-73 PMID: 16007186 07/12/2005
  • Heat shock factor 1-deficient mice exhibit decreased recovery of hearing following noise overstimulation. (Fairfield DA, Lomax MI, Dootz GA, Chen S, Galecki AT, Benjamin IJ, Dolan DF, Altschuler RA) J Neurosci Res 2005 Aug 15;81(4):589-96 PMID: 15952177 06/14/2005
  • Discovering the full spectrum of cardiovascular disease: Minority Health Summit 2003: report of the Basic Science Writing Group. (Benjamin IJ, Arnett DK, Loscalzo J, American Heart Association Basic Science Writing Group) Circulation 2005 Mar 15;111(10):e120-3 PMID: 15769753 03/17/2005
  • Learning from failure: congestive heart failure in the postgenomic age. (Benjamin IJ, Schneider MD) J Clin Invest 2005 Mar;115(3):495-9 PMID: 15765130 PMCID: PMC1052014 03/15/2005
  • Small heat shock proteins: a new classification scheme in mammals. (Taylor RP, Benjamin IJ) J Mol Cell Cardiol 2005 Mar;38(3):433-44 PMID: 15733903 03/01/2005
  • Mouse HSF1 disruption perturbs redox state and increases mitochondrial oxidative stress in kidney. (Yan LJ, Rajasekaran NS, Sathyanarayanan S, Benjamin IJ) Antioxid Redox Signal 2005 Mar-Apr;7(3-4):465-71 PMID: 15706094 02/12/2005
  • The stress or heat shock (HS) response: insights from transgenic mouse models. (Christians ES, Benjamin IJ) Methods 2005 Feb;35(2):170-5 PMID: 15649844 01/15/2005
  • Heat shock proteins in mammalian development. (Christians ES, Zhou Q, Renard J, Benjamin IJ) Semin Cell Dev Biol 2003 Oct;14(5):283-90 PMID: 14986858 02/28/2004
  • [Effects of hsf1 genotype on the constitutive expression of alphaB-crystallin in mice myocardium]. (Liu L, Zhang HH, Ding GX, Cheng YL, Yan LJ, Benjamin IJ) Zhongguo Ying Yong Sheng Li Xue Za Zhi 2004 Feb;20(1):30-3 PMID: 21162300 02/01/2004
  • Use of Hsf1(-/-) mice reveals an essential role for HSF1 to protect lung against cadmium-induced injury. (Wirth D, Christians E, Li X, Benjamin IJ, Gustin P) Toxicol Appl Pharmacol 2003 Oct 01;192(1):12-20 PMID: 14554099 10/14/2003
  • Localized recruitment of a chromatin-remodeling activity by an activator in vivo drives transcriptional elongation. (Corey LL, Weirich CS, Benjamin IJ, Kingston RE) Genes Dev 2003 Jun 01;17(11):1392-401 PMID: 12782657 PMCID: PMC196071 06/05/2003
  • Heat shock factor 1-independent activation of dendritic cells by heat shock: implication for the uncoupling of heat-mediated immunoregulation from the heat shock response. (Zheng H, Benjamin IJ, Basu S, Li Z) Eur J Immunol 2003 Jun;33(6):1754-62 PMID: 12778494 06/05/2003
  • Heat shock transcription factor 2 is not essential for embryonic development, fertility, or adult cognitive and psychomotor function in mice. (McMillan DR, Christians E, Forster M, Xiao X, Connell P, Plumier JC, Zuo X, Richardson J, Morgan S, Benjamin IJ) Mol Cell Biol 2002 Nov;22(22):8005-14 PMID: 12391166 PMCID: PMC134743 10/23/2002
  • Mouse heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damage. (Yan LJ, Christians ES, Liu L, Xiao X, Sohal RS, Benjamin IJ) EMBO J 2002 Oct 01;21(19):5164-72 PMID: 12356732 PMCID: PMC129050 10/03/2002
  • Stress pathways in the rat cochlea and potential for protection from acquired deafness. (Altschuler RA, Fairfield D, Cho Y, Leonova E, Benjamin IJ, Miller JM, Lomax MI) Audiol Neurootol 2002 May-Jun;7(3):152-6 PMID: 12053136 06/08/2002
  • Exercise, estrogen, and ischemic cardioprotection by heat shock protein 70. (Benjamin IJ, Christians E) Circ Res 2002 May 03;90(8):833-5 PMID: 11988480 05/04/2002
  • Heat shock factor 1 and heat shock proteins: Critical partners in protection against acute cell injury. (Christians ES, Yan LJ, Benjamin IJ) Crit Care Med 2002 Jan;30(1 Supp):S43-S50 PMID: 11839944 02/13/2002
  • Heat shock factor 1-mediated thermotolerance prevents cell death and results in G2/M cell cycle arrest. (Luft JC, Benjamin IJ, Mestril R, Dix DJ) Cell Stress Chaperones 2001 Oct;6(4):326-36 PMID: 11795469 PMCID: PMC434415 01/25/2002
  • Heat shock factor 1 and heat shock proteins: critical partners in protection against acute cell injury. (Christians ES, Yan LJ, Benjamin IJ) Crit Care Med 2002 Jan;30(1 Suppl):S43-50 PMID: 11782560 01/10/2002
  • Matrix metalloproteinases: from biology to therapeutic strategies in cardiovascular disease. (Benjamin IJ) J Investig Med 2001 Sep;49(5):381-97 PMID: 11523694 08/29/2001
  • Maternal effect of Hsf1 on reproductive success. (Christians E, Davis AA, Thomas SD, Benjamin IJ) Nature 2000 Oct 12;407(6805):693-4 PMID: 11048707 10/26/2000
  • Protective responses in the ischemic myocardium. (Williams RS, Benjamin IJ) J Clin Invest 2000 Oct;106(7):813-8 PMID: 11018066 PMCID: PMC381426 10/06/2000
  • Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of hsp90-binding agents. (Bagatell R, Paine-Murrieta GD, Taylor CW, Pulcini EJ, Akinaga S, Benjamin IJ, Whitesell L) Clin Cancer Res 2000 Aug;6(8):3312-8 PMID: 10955818 08/24/2000
  • Disruption of heat shock factor 1 reveals an essential role in the ubiquitin proteolytic pathway. (Pirkkala L, Alastalo TP, Zuo X, Benjamin IJ, Sistonen L) Mol Cell Biol 2000 Apr;20(8):2670-5 PMID: 10733569 PMCID: PMC85482 03/25/2000
  • HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice. (Xiao X, Zuo X, Davis AA, McMillan DR, Curry BB, Richardson JA, Benjamin IJ) EMBO J 1999 Nov 01;18(21):5943-52 PMID: 10545106 PMCID: PMC1171660 11/02/1999
  • Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association. (Grundy SM, Benjamin IJ, Burke GL, Chait A, Eckel RH, Howard BV, Mitch W, Smith SC Jr, Sowers JR) Circulation 1999 Sep 07;100(10):1134-46 PMID: 10477542 09/08/1999
  • Stress-response proteins in cardiovascular disease. (Xiao X, Benjamin IJ) Am J Hum Genet 1999 Mar;64(3):685-90 PMID: 10053001 PMCID: PMC1377784 03/03/1999
  • Stress (heat shock) proteins: molecular chaperones in cardiovascular biology and disease. (Benjamin IJ, McMillan DR) Circ Res 1998 Jul 27;83(2):117-32 PMID: 9686751 08/01/1998
  • Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heat-inducible apoptosis. (McMillan DR, Xiao X, Shao L, Graves K, Benjamin IJ) J Biol Chem 1998 Mar 27;273(13):7523-8 PMID: 9516453 04/29/1998
  • Temporospatial expression of the small HSP/alpha B-crystallin in cardiac and skeletal muscle during mouse development. (Benjamin IJ, Shelton J, Garry DJ, Richardson JA) Dev Dyn 1997 Jan;208(1):75-84 PMID: 8989522 01/01/1997
  • Continuous contractile activity induces fiber type specific expression of HSP70 in skeletal muscle. (Neufer PD, Ordway GA, Hand GA, Shelton JM, Richardson JA, Benjamin IJ, Williams RS) Am J Physiol 1996 Dec;271(6 Pt 1):C1828-37 PMID: 8997182 12/01/1996
  • Differential expression of B-crystallin and Hsp27 in skeletal muscle during continuous contractile activity. Relationship to myogenic regulatory factors. (Neufer PD, Benjamin IJ) J Biol Chem 1996 Sep 27;271(39):24089-95 PMID: 8798647 09/27/1996
  • Cardioprotective effects of 70-kDa heat shock protein in transgenic mice. (Radford NB, Fina M, Benjamin IJ, Moreadith RW, Graves KH, Zhao P, Gavva S, Wiethoff A, Sherry AD, Malloy CR, Williams RS) Proc Natl Acad Sci U S A 1996 Mar 19;93(6):2339-42 PMID: 8637874 PMCID: PMC39797 03/19/1996
  • Stress proteins: is their application in clinical medicine on the horizon? (Benjamin IJ) Hepatology 1993 Dec;18(6):1532-4 PMID: 8244280 12/01/1993
  • Human heat shock protein 70 (hsp70) protects murine cells from injury during metabolic stress. (Williams RS, Thomas JA, Fina M, German Z, Benjamin IJ) J Clin Invest 1993 Jul;92(1):503-8 PMID: 8326014 PMCID: PMC293638 07/01/1993
  • beta Adrenergic receptor desensitisation may serve a cardioprotective role. (Tan LB, Benjamin IJ, Clark WA) Cardiovasc Res 1992 Jun;26(6):608-14 PMID: 1360332 06/01/1992
  • Induction of stress proteins in cultured myogenic cells. Molecular signals for the activation of heat shock transcription factor during ischemia. (Benjamin IJ, Horie S, Greenberg ML, Alpern RJ, Williams RS) J Clin Invest 1992 May;89(5):1685-9 PMID: 1569208 PMCID: PMC443048 05/01/1992
  • Stress proteins and cardiovascular disease. (Williams RS, Benjamin IJ) Mol Biol Med 1991 Apr;8(2):197-206 PMID: 1806762 04/01/1991
  • Activation of the heat shock transcription factor by hypoxia in mammalian cells. (Benjamin IJ, Kröger B, Williams RS) Proc Natl Acad Sci U S A 1990 Aug;87(16):6263-7 PMID: 1696723 PMCID: PMC54513 08/01/1990
  • Isoproterenol-induced myocardial fibrosis in relation to myocyte necrosis. (Benjamin IJ, Jalil JE, Tan LB, Cho K, Weber KT, Clark WA) Circ Res 1989 Sep;65(3):657-70 PMID: 2527639 09/01/1989
  • Cardiac hypertrophy in idiopathic dilated congestive cardiomyopathy: a clinicopathologic study. (Benjamin IJ, Schuster EH, Bulkley BH) Circulation 1981 Sep;64(3):442-7 PMID: 6455215 09/01/1981
  • Last update: 09/14/2017
    jenkins-FCD Prod-130 96200611f8481f0aa4f84230b11dd74d063847a3