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Medical College of Wisconsin

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Jeffrey L. Segar MD

Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Pediatrics Neonatology

Member of the Cardiovascular Research Center

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Publications (172)

Maternal low-sodium diet impairs hippocampal neurogenesis and cognition in adult mouse offspring. (Ke X, Grobe CC, Grobe JL, Yu W, Reho JJ, Varberg KM, Lane RH, Segar JL) Am J Physiol Regul Integr Comp Physiol 2026 May 01;330(5):R463-R477 PMID: 41902531 PMCID: PMC13160179 SCOPUS ID: 2-s2.0-105036303576 03/28/2026

Kidney care at NICU discharge and follow-up recommendations for preterm infants<34 weeks. (Slagle CL, Chmielewski JL, Rumpel JA, Sanderson KR, Schuh MP, Starr MC, Segar JL, Ambalavanan N, Askenazi D, Selewski D, Charlton JR, Harer MW, Neonatal Kidney Health Consensus Workshop) J Perinatol 2026 Mar;46(3):498-507 PMID: 41748935 PMCID: PMC13008752 SCOPUS ID: 2-s2.0-105031931760 02/27/2026

Titrating cumulative neonatal hyperoxia in mice to model bronchopulmonary dysplasia severities. (Dir B, Mishra R, Hennen N, Mooers E, Teng RJ, Konduri G, Segar JL, Grobe J, Hodges MR, Mouradian GC) Am J Respir Cell Mol Biol 2026 Feb 21 PMID: 41738294 PMCID: PMC13068295 02/25/2026

Sodium Supplementation Algorithm to Promote Growth in Infants Who Are Preterm: Randomized Clinical Trial (Liberios BM, Sokol GM, Rakow H, Mosesso K, Hole V, Wong WW, Chacko SK, Segar JL.) Pediatrics Open Science Pediatrics Open Science (2026) 2 (1): 1–10. 02/01/2026

Validation of a novel Bayesian predictive algorithm for detection of carbon dioxide retention using retrospective neonatal ICU data (Viehl LT, Segar JL, Vesoulis ZA) Journal of Perinatology January 2026;46(1):31-37 SCOPUS ID: 2-s2.0-105011339707 01/01/2026

Maternal low sodium intake and early postnatal diuretics program metabolic and ventilatory dysfunction in mice. (Madison AM, Araya BR, Grobe CC, Grobe JL, Segar JL, Mouradian GC Jr) Pediatr Res 2025 Dec 27 PMID: 41455798 SCOPUS ID: 2-s2.0-105026248092 12/28/2025

Data harmonization framework for neonatal hypoxic-ischemic encephalopathy studies (Hsiao CH, Foster AN, Mcdonald SA, Vyas R, Ashraf A, Bao R, Tran L, Kesri A, Darzidehkalani E, Soldatelli MD, Auman JO, Soul JS, Chalak LF, Cotten CM, Shankaran S, Laptook AR, Grant PE, Ou Y, Walsh MC, Eichenwald EC, Truog WE, Merhar SL, Poindexter BLB, He L, Cotten CM, Hamrick SEG, Sokol GM, Bates SV, Sanchez PJ, Shepherd EG, Ho ML, Auman JO, Van Meurs KP, Hintz SR, Bonifacio SL, Frantz ID, Ambalavanan N, Bell EF, McNamara P, Watterberg K, D Angio CT, Tyson JE, Green CE, Yoder BA, Shankaran S, Chawla S, Caplan MS, Polin RA, Keszler M, Oh W, Vohr BR, Hensman AM, Alksninis B, Basso K, Bishop C, Bliss J, Burke RT, Cashore W, Caskey M, Gingras D, Guerina N, Johnson K, Keszler ML, Knoll AM, Leach TM, Leonard MR, Little E, McGowan EC, McKinley LT, Mirza H, Shah BA, Sommers R, Stephens BE, Ventura S, Vieira E, Watson VE, Hibbs AM, Wilson-Costello DE, Walsh MC, Roth E, Newman NS, Bhola M, Siner BS, Stork EK, Yalcinkaya G, Pallotto EK, Kilbride HW, Gauldin C, Holmes A, Johnson K, Knutson A, Merhar SL, Schibler K, Poindexter BLB, Kallapur SG, Gratton TL, Grisby C, Alexander B, Fischer EE, Hessling J) JAMIA Open 1 October 2025;8(5) SCOPUS ID: 2-s2.0-105015429725 10/01/2025 1 Citation

Validation of a novel Bayesian predictive algorithm for detection of carbon dioxide retention using retrospective neonatal ICU data. (Viehl LT, Segar JL, Vesoulis ZA) J Perinatol 2026 Jan;46(1):31-37 PMID: 40702156 SCOPUS ID: 2-s2.0-105011339707 07/24/2025

Angiotensin AT1R expressing cells within the ventral hypothalamus modulate integrative control of cardiometabolic functions (Pasos J, Wagner VA, Lawton SBR, Madison AM, Nandani K, Mathieu NM, Grobe CC, Reho JJ, Freudinger BP, Sherman AJ, Brozoski DT, Morselli LL, Burnett CML, Segar JL, Nakagawa P, Sigmund CD, Grobe JL) Iscience 18 July 2025;28(7) SCOPUS ID: 2-s2.0-105007661529 07/18/2025

Angiotensin AT₁R expressing cells within the ventral hypothalamus modulate integrative control of cardiometabolic functions. (Pasos J, Wagner VA, Lawton SBR, Madison AM, Nandani K, Mathieu NM, Grobe CC, Reho JJ, Freudinger BP, Sherman AJ, Brozoski DT, Morselli LL, Burnett CML, Segar JL, Nakagawa P, Sigmund CD, Grobe JL) iScience 2025 Jul 18;28(7):112797 PMID: 40585361 PMCID: PMC12205624 SCOPUS ID: 2-s2.0-105007661529 07/01/2025

Expanded discussion of kidney health monitoring for critically ill term and late preterm infants after acute kidney injury: a report from the Neonatal Kidney Health Consensus Workshop. (Vuong KT, Liberio BM, Schwartz SR, Menon S, Mohamed TH, Soranno DE, Johnson KS, Jetton JG, Merrill KA, Hanna M, Starr MC, Selewski DT, Steflik HJ, Neonatal Kidney Health Consensus Workshop) Pediatr Nephrol 2025 Sep;40(9):2993-3004 PMID: 40232498 PMCID: PMC12301098 SCOPUS ID: 2-s2.0-105003421966 04/15/2025 5 Citations

NICHD Magnetic Resonance Brain Imaging Score in Term Infants With Hypoxic-Ischemic Encephalopathy: A Secondary Analysis of a Randomized Clinical Trial. (Shankaran S, Laptook AR, Guimaraes C, Murnick J, McDonald SA, Das A, Petrie Huitema CM, Pappas A, Higgins RD, Hintz SR, Zaterka-Baxter KM, Van Meurs KP, Sokol GM, Chalak LF, Colaizy TT, Devaskar U, Tyson JE, Reynolds AM, DeMauro SB, Sánchez PJ, Laughon MM, Carlo WA, Watterberg K, Puopolo KM, Hibbs AM, Hamrick SEG, Cotten CM, Barks J, Poindexter BB, Truog WE, D'Angio CT, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network) JAMA Pediatr 2025 Apr 01;179(4):383-395 PMID: 39960680 PMCID: PMC11833650 SCOPUS ID: 2-s2.0-105003190017 02/17/2025 2 Citations

Definitive Evidence for the Identification and Function of Renin-Expressing Cholinergic Neurons in the Nucleus Ambiguus. (Fekete ÉM, Gomez J, Ghobrial M, Kaminski K, Muskus PC, Boychuk CR, Hantke Guixa A, Vazirabad I, Xie M, Ganiyu A, Golosova D, Mathieu NM, Wang YB, Lu KT, Wackman KK, Brozoski DT, Mouradian GC, Hodges MR, Segar JL, Grobe JL, Sigmund CD, Nakagawa P) Hypertension 2025 Feb;82(2):282-292 PMID: 39618396 PMCID: PMC11735315 SCOPUS ID: 2-s2.0-85210962734 12/02/2024 7 Citations

Early-life sodium restriction programs autonomic dysfunction and salt sensitivity in male C57BL/6J mice. (Ziegler AA, Lawton SBR, Fekete EM, Brozoski DT, Wagner VA, Grobe CC, Sigmund CD, Nakagawa P, Grobe JL, Segar JL) Am J Physiol Regul Integr Comp Physiol 2025 Jan 01;328(1):R109-R120 PMID: 39548798 PMCID: PMC11905802 SCOPUS ID: 2-s2.0-85213215949 11/16/2024 2 Citations

Somatic growth outcomes in response to an individualized neonatal sodium supplementation protocol. (Stalter EJ, Verhofste SL, Dagle JM, Steinbach EJ, Ten Eyck P, Wendt L, Segar JL, Harshman LA) J Perinatol 2025 Mar;45(3):305-311 PMID: 39420073 PMCID: PMC12410120 SCOPUS ID: 2-s2.0-85207249232 10/18/2024 5 Citations

Angiotensin in the Arcuate: Mechanisms Integrating Cardiometabolic Control: The 2022 COH Mid-Career Award for Research Excellence. (Lawton SBR, Wagner VA, Nakagawa P, Segar JL, Sigmund CD, Morselli LL, Grobe JL) Hypertension 2024 Nov;81(11):2209-2217 PMID: 39315447 PMCID: PMC11483214 SCOPUS ID: 2-s2.0-85205521844 09/24/2024 4 Citations

Kidney Health Monitoring in Neonatal Intensive Care Unit Graduates: A Modified Delphi Consensus Statement. (Starr MC, Harer MW, Steflik HJ, Gorga S, Ambalavanan N, Beck TM, Chaudhry PM, Chmielewski JL, Defreitas MJ, Fuhrman DY, Hanna M, Joseph C, Kwiatkowski DM, Krawczeski CD, Liberio BM, Menon S, Mohamed TH, Rumpel JA, Sanderson KR, Schuh MP, Segar JL, Slagle CL, Soranno DE, Vuong KT, Charlton JR, Gist KM, Askenazi DJ, Selewski DT, Neonatal Kidney Health Consensus Workshop) JAMA Netw Open 2024 Sep 03;7(9):e2435043 PMID: 39269711 PMCID: PMC12163980 SCOPUS ID: 2-s2.0-85204167731 09/13/2024 32 Citations

Long-term Metabolic Dysfunction Programming in Female Mice by Serial Moderate Restriction of a High-fat High-sucrose Diet. (Wildes MP, Fernando DG, Grobe CC, Reho JJ, Grobe JL, Kidambi S, Kindel TL, Kwitek AE, Segar JL, Williams JS, Morselli LL) Endocrinology 2024 Aug 27;165(10) PMID: 39236000 PMCID: PMC11408931 SCOPUS ID: 2-s2.0-85204510410 09/05/2024 1 Citation

Correction: Perinatal risk factors associated with acute kidney injury severity and duration among infants born extremely preterm. (Sanderson K, Griffin R, Anderson N, South AM, Swanson JR, Zappitelli M, Steflik HJ, DeFreitas MJ, Charlton J, Askenazi D, Neonatal Kidney Collaborative (NKC) Research Committee) Pediatr Res 2024 Sep;96(4):1096 PMID: 39030257 SCOPUS ID: 2-s2.0-85199300546 07/20/2024

Perinatal risk factors associated with acute kidney injury severity and duration among infants born extremely preterm. (Sanderson K, Griffin R, Anderson N, South AM, Swanson JR, Zappitelli M, Steflik HJ, DeFreitas MJ, Charlton J, Askenazi D, Neonatal Kidney Collaborative (NKC) Research Committee) Pediatr Res 2024 Aug;96(3):740-749 PMID: 38438550 PMCID: PMC11371939 SCOPUS ID: 2-s2.0-85186602995 03/05/2024 7 Citations

Incidence, Risk Factors, and Outcomes Associated With Recurrent Neonatal Acute Kidney Injury in the AWAKEN Study. (Rutledge AD, Griffin RL, Vincent K, Askenazi DJ, Segar JL, Kupferman JC, Rastogi S, Selewski DT, Steflik HJ, Neonatal Kidney Collaborative) JAMA Netw Open 2024 Feb 05;7(2):e2355307 PMID: 38329754 PMCID: PMC10853837 SCOPUS ID: 2-s2.0-85184723684 02/08/2024 11 Citations

Modulatory effects of estrous cycle on ingestive behaviors and energy balance in young adult C57BL/6J mice maintained on a phytoestrogen-free diet. (Reho JJ, Muskus PC, Bennett DM, Grobe CC, Burnett CML, Nakagawa P, Segar JL, Sigmund CD, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2024 Mar 01;326(3):R242-R253 PMID: 38284128 PMCID: PMC11213288 SCOPUS ID: 2-s2.0-85186271298 01/29/2024 5 Citations

Differences in Fluid, Electrolyte, and Energy Balance in C57BL/6J Mice (Mus musculus) in Metabolic Caging at Thermoneutral or Standard Room Temperatures. (Lawton SB, Grobe CC, Reho JJ, Raff H, Thulin JD, Jensen ES, Burnett CM, Segar JL, Grobe JL) J Am Assoc Lab Anim Sci 2024 Mar 01;63(2):190-200 PMID: 38191147 PMCID: PMC11022944 SCOPUS ID: 2-s2.0-85192114074 01/09/2024 7 Citations

Fluid and electrolyte management in the neonate and what can go wrong. (Segar JL, Jetton JG) Curr Opin Pediatr 2024 Apr 01;36(2):198-203 PMID: 37962361 PMCID: PMC10932865 SCOPUS ID: 2-s2.0-85187024349 11/14/2023 12 Citations

Early-life sodium deprivation programs long-term changes in ingestive behaviors and energy expenditure in C57BL/6J mice. (Ziegler AA, Lawton SBR, Grobe CC, Reho JJ, Freudinger BP, Burnett CML, Nakagawa P, Grobe JL, Segar JL) Am J Physiol Regul Integr Comp Physiol 2023 Nov 01;325(5):R576-R592 PMID: 37720996 PMCID: PMC10866575 SCOPUS ID: 2-s2.0-85174752582 09/18/2023 5 Citations

Caffeine and kidney function at two years in former extremely low gestational age neonates. (Harer MW, Griffin R, Askenazi DJ, Fuloria M, Guillet R, Hanna M, Schuh MP, Slagle C, Woroniecki R, Neonatal Kidney Collaborative Research Committee, Charlton JR) Pediatr Res 2024 Jan;95(1):257-266 PMID: 37660176 PMCID: PMC11293578 SCOPUS ID: 2-s2.0-85169538648 09/03/2023 3 Citations

Sodium and Growth in Preterm Infants: A Review. (Araya BR, Ziegler AA, Grobe CC, Grobe JL, Segar JL) Newborn (Clarksville) 2023;2(2):142-147 PMID: 37614871 PMCID: PMC10445331 08/24/2023

Genetic Ablation of Prorenin Receptor in the Rostral Ventrolateral Medulla Influences Blood Pressure and Hydromineral Balance in Deoxycorticosterone-Salt Hypertension. (Mathieu NM, Fekete EM, Muskus PC, Brozoski DT, Lu KT, Wackman KK, Gomez J, Fang S, Reho JJ, Grobe CC, Vazirabad I, Mouradian GC Jr, Hodges MR, Segar JL, Grobe JL, Sigmund CD, Nakagawa P) Function (Oxf) 2023;4(5):zqad043 PMID: 37609445 PMCID: PMC10440998 SCOPUS ID: 2-s2.0-85168790693 08/23/2023 6 Citations

Acute Kidney Injury Defined by Fluid-Corrected Creatinine in Premature Neonates: A Secondary Analysis of the PENUT Randomized Clinical Trial. (Starr MC, Griffin RL, Harer MW, Soranno DE, Gist KM, Segar JL, Menon S, Gordon L, Askenazi DJ, Selewski DT) JAMA Netw Open 2023 Aug 01;6(8):e2328182 PMID: 37561461 PMCID: PMC10415963 SCOPUS ID: 2-s2.0-85167532593 08/10/2023 19 Citations

Cardiometabolic Effects of DOCA-Salt in Mice Depend on Ambient Temperature. (Grobe CC, Reho JJ, Brown-Williams D, Ziegler AA, Mathieu NM, Lawton SBR, Fekete EM, Brozoski DT, Wackman KK, Burnett CML, Nakagawa P, Sigmund CD, Segar JL, Grobe JL) Hypertension 2023 Sep;80(9):1871-1880 PMID: 37470185 PMCID: PMC10528934 SCOPUS ID: 2-s2.0-85168254483 07/20/2023 3 Citations

Evidence-based approach to diuretic therapy in the neonate (Segar JL) Neonatology Questions and Controversies Renal Fluid and Electrolyte Disorders 1 January 2023:114-124 SCOPUS ID: 2-s2.0-105016629097 01/01/2023 4 Citations

Association of Fluid Balance With Short- and Long-term Respiratory Outcomes in Extremely Premature Neonates: A Secondary Analysis of a Randomized Clinical Trial. (Starr MC, Griffin R, Gist KM, Segar JL, Raina R, Guillet R, Nesargi S, Menon S, Anderson N, Askenazi DJ, Selewski DT, Neonatal Kidney Collaborative Research Committee) JAMA Netw Open 2022 Dec 01;5(12):e2248826 PMID: 36580332 PMCID: PMC9856967 SCOPUS ID: 2-s2.0-85145242395 12/30/2022 41 Citations

ARRB2 (β-Arrestin-2) Deficiency Alters Fluid Homeostasis and Blood Pressure Regulation. (Mathieu NM, Nakagawa P, Grobe CC, Reho JJ, Brozoski DT, Lu KT, Wackman KK, Ritter ML, Segar JL, Grobe JL, Sigmund CD) Hypertension 2022 Nov;79(11):2480-2492 PMID: 36215165 PMCID: PMC9669141 SCOPUS ID: 2-s2.0-85140375825 10/11/2022 16 Citations

Chronic intracerebroventricular infusion of angiotensin II causes dose- and sex-dependent effects on intake behaviors and energy homeostasis in C57BL/6J mice. (Oliveira V, Reho JJ, Balapattabi K, Ritter ML, Mathieu NM, Opichka MA, Lu KT, Grobe CC, Silva SD Jr, Wackman KK, Nakagawa P, Segar JL, Sigmund CD, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2022 Oct 01;323(4):R410-R421 PMID: 35816717 PMCID: PMC9512112 SCOPUS ID: 2-s2.0-85138457982 07/12/2022 7 Citations

Postnatal fluid balance - it's time to pay attention. (Steflik HJ, Segar JL) J Perinatol 2022 Aug;42(8):985-986 PMID: 35725803 SCOPUS ID: 2-s2.0-85132132546 06/21/2022 2 Citations

Low Sodium Supply in Early Life Causes Growth Restriction and Programs Long-Term Changes in Energy Homeostasis. (Ziegler AA, Grobe CC, Reho JJ, Grobe JL, Segar JL) FASEB J 2022 May;36 Suppl 1 PMID: 35555376 SCOPUS ID: 2-s2.0-85130017162 05/14/2022

Deletion of Prorenin Receptor in the Rostral Ventrolateral Medulla Results in Biphasic and Sex-Dependent Pressor Responses in Deoxycorticosterone Acetate-salt Hypertension. (Nakagawa P, Brozoski D, Mathieu NM, Lu KT, Gomez J, Reho J, Fang S, Segar JL, Grobe JL, Sigmund CD) FASEB J 2022 May;36 Suppl 1 PMID: 35557064 SCOPUS ID: 2-s2.0-85130045126 05/14/2022

Cardiometabolic effects of DOCA-salt in male C57BL/6J mice are variably dependent on sodium and nonsodium components of diet. (Patil CN, Ritter ML, Wackman KK, Oliveira V, Balapattabi K, Grobe CC, Brozoski DT, Reho JJ, Nakagawa P, Mouradian GC Jr, Kriegel AJ, Kwitek AE, Hodges MR, Segar JL, Sigmund CD, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2022 Jun 01;322(6):R467-R485 PMID: 35348007 PMCID: PMC9054347 SCOPUS ID: 2-s2.0-85129779185 03/30/2022 13 Citations

Methods for the Comprehensive in vivo Analysis of Energy Flux, Fluid Homeostasis, Blood Pressure, and Ventilatory Function in Rodents. (Reho JJ, Nakagawa P, Mouradian GC Jr, Grobe CC, Saravia FL, Burnett CML, Kwitek AE, Kirby JR, Segar JL, Hodges MR, Sigmund CD, Grobe JL) Front Physiol 2022;13:855054 PMID: 35283781 PMCID: PMC8914175 SCOPUS ID: 2-s2.0-85126220642 03/15/2022 29 Citations

Short-term Housing in Metabolic Caging on Measures of Energy and Fluid Balance in Male C57BL/6J Mice ( Mus musculus). (Ziegler AA, Grobe CC, Reho JJ, Jensen ES, Thulin JD, Segar JL, Grobe JL) J Am Assoc Lab Anim Sci 2022 Mar 01;61(2):132-139 PMID: 34996529 PMCID: PMC8956215 SCOPUS ID: 2-s2.0-85126266838 01/09/2022 17 Citations

William E. Segar (1923–2021): pioneer and educator (Segar JL) Pediatric Research January 2022;91(1):262-263 SCOPUS ID: 2-s2.0-85102696400 01/01/2022

Cardiorespiratory management of infants born at 22 weeks' gestation: The Iowa approach. (Dagle JM, Rysavy MA, Hunter SK, Colaizy TT, Elgin TG, Giesinger RE, McElroy SJ, Harmon HM, Klein JM, McNamara PJ, Segar JL, Iowa Neonatal Program) Semin Perinatol 2022 Feb;46(1):151545 PMID: 34893337 SCOPUS ID: 2-s2.0-85122953797 12/12/2021 18 Citations

Fluid management considerations in extremely preterm infants born at 22-24 weeks of gestation. (Ågren J, Segar JL, Söderström F, Bell EF) Semin Perinatol 2022 Feb;46(1):151541 PMID: 34848064 SCOPUS ID: 2-s2.0-85120344860 12/02/2021 41 Citations

The use of simulated research rehearsals to address barriers to cardiopulmonary physiology research in the neonatal intensive care unit (Billa R, Byrne D, Barnard C, Schmelzel ML, Spellman E, Segar JL, Tomasson MH, Dagle JM, Bates ML, Elgin TG) Human Factors in Healthcare December 2021;1 SCOPUS ID: 2-s2.0-85164098566 12/01/2021 1 Citation

Fluid management, electrolytes imbalance and renal management in neonates with neonatal encephalopathy treated with hypothermia (Segar JL, Chock VYL, Harer MW, Selewski DT, Askenazi DJ) Seminars in Fetal and Neonatal Medicine August 2021;26(4) SCOPUS ID: 2-s2.0-85107997163 08/01/2021 18 Citations

Fluid management, electrolytes imbalance and renal management in neonates with neonatal encephalopathy treated with hypothermia. (Segar JL, Chock VY, Harer MW, Selewski DT, Askenazi DJ, Newborn Brain Society Guidelines and Publications Committee) Semin Fetal Neonatal Med 2021 Aug;26(4):101261 PMID: 34140246 SCOPUS ID: 2-s2.0-85107997163 06/19/2021 18 Citations

Maturational changes in sodium metabolism in periviable infants. (Segar JL, Grobe CC, Grobe JL) Pediatr Nephrol 2021 Nov;36(11):3693-3698 PMID: 34013388 PMCID: PMC8815317 SCOPUS ID: 2-s2.0-85106237462 05/21/2021 25 Citations

William E. Segar (1923-2021): pioneer and educator. (Segar JL) Pediatr Res 2022 Jan;91(1):262-263 PMID: 33731815 SCOPUS ID: 2-s2.0-85102696400 03/19/2021

Extended Work Shifts and Neurobehavioral Performance in Resident-Physicians. (Rahman SA, Sullivan JP, Barger LK, St Hilaire MA, O'Brien CS, Stone KL, Phillips AJK, Klerman EB, Qadri S, Wright KP Jr, Halbower AC, Segar JL, McGuire JK, Vitiello MV, de la Iglesia HO, Poynter SE, Yu PL, Sanderson AL, Zee PC, Landrigan CP, Czeisler CA, Lockley SW, ROSTERS STUDY GROUP) Pediatrics 2021 Mar;147(3) PMID: 33619044 PMCID: PMC7919117 SCOPUS ID: 2-s2.0-85102538410 02/24/2021 35 Citations

Dissociable effects of dietary sodium in early life upon somatic growth, fluid homeostasis, and spatial memory in mice of both sexes. (Segar JL, Grobe CC, Balapattabi K, Ritter ML, Reho JJ, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2021 Apr 01;320(4):R438-R451 PMID: 33439766 PMCID: PMC8238146 SCOPUS ID: 2-s2.0-85103803949 01/14/2021 10 Citations

Diuretic use, acute kidney injury, and premature infants: the call for evidence-based guidelines (Segar J, Jetton JG) Pediatric Nephrology December 2020;36(12):3807-3811 SCOPUS ID: 2-s2.0-85110205560 12/01/2020 3 Citations

Limitations of Conventional Magnetic Resonance Imaging as a Predictor of Death or Disability Following Neonatal Hypoxic-Ischemic Encephalopathy in the Late Hypothermia Trial. (Laptook AR, Shankaran S, Barnes P, Rollins N, Do BT, Parikh NA, Hamrick S, Hintz SR, Tyson JE, Bell EF, Ambalavanan N, Goldberg RN, Pappas A, Huitema C, Pedroza C, Chaudhary AS, Hensman AM, Das A, Wyckoff M, Khan A, Walsh MC, Watterberg KL, Faix R, Truog W, Guillet R, Sokol GM, Poindexter BB, Higgins RD, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network) J Pediatr 2021 Mar;230:106-111.e6 PMID: 33189747 PMCID: PMC7914162 SCOPUS ID: 2-s2.0-85097464446 11/16/2020 23 Citations

Effect on patient safety of a resident physician schedule without 24-hour shifts (Landrigan CP, Rahman SA, Sullivan JP, Vittinghoff E, Barger LK, Sanderson AL, Wright KP, O'Brien CS, Qadri S, St Hilaire MA, Halbower AC, Segar JL, McGuire JK, Vitiello MV, de la Iglesia HO, Poynter SE, Yu PL, Zee PC, Lockley SW, Stone KL, Czeisler CA) Obstetrical and Gynecological Survey November 2020;75(11):657-659 SCOPUS ID: 2-s2.0-85098458420 11/01/2020

Quantification of body fluid compartmentalization by combined time-domain nuclear magnetic resonance and bioimpedance spectroscopy. (Segar JL, Balapattabi K, Reho JJ, Grobe CC, Burnett CML, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2021 Jan 01;320(1):R44-R54 PMID: 33085913 PMCID: PMC7847054 SCOPUS ID: 2-s2.0-85099721279 10/22/2020 14 Citations

Effect on Patient Safety of a Resident Physician Schedule without 24-Hour Shifts. (Landrigan CP, Rahman SA, Sullivan JP, Vittinghoff E, Barger LK, Sanderson AL, Wright KP Jr, O'Brien CS, Qadri S, St Hilaire MA, Halbower AC, Segar JL, McGuire JK, Vitiello MV, de la Iglesia HO, Poynter SE, Yu PL, Zee PC, Lockley SW, Stone KL, Czeisler CA, ROSTERS Study Group) N Engl J Med 2020 Jun 25;382(26):2514-2523 PMID: 32579812 PMCID: PMC7405505 SCOPUS ID: 2-s2.0-85087098274 06/25/2020 87 Citations

Increased aortic stiffness and elevated blood pressure in response to exercise in adult survivors of prematurity. (Barnard CR, Peters M, Sindler AL, Farrell ET, Baker KR, Palta M, Stauss HM, Dagle JM, Segar J, Pierce GL, Eldridge MW, Bates ML) Physiol Rep 2020 Jun;8(12):e14462 PMID: 32562387 PMCID: PMC7305240 SCOPUS ID: 2-s2.0-85086752636 06/21/2020 14 Citations

Feeding Formula Eliminates the Necessity of Bacterial Dysbiosis and Induces Inflammation and Injury in the Paneth Cell Disruption Murine NEC Model in an Osmolality-Dependent Manner. (Lueschow SR, Kern SL, Gong H, Grobe JL, Segar JL, Carlson SJ, McElroy SJ) Nutrients 2020 Mar 26;12(4) PMID: 32224880 PMCID: PMC7230818 SCOPUS ID: 2-s2.0-85082571970 04/01/2020 13 Citations

Rethinking furosemide use for infants with bronchopulmonary dysplasia. (Segar JL) Pediatr Pulmonol 2020 May;55(5):1100-1103 PMID: 32176837 SCOPUS ID: 2-s2.0-85081729340 03/17/2020 11 Citations

Fetal storage of osmotically inactive sodium. (Segar JL, Grobe CC, Grobe JL) Am J Physiol Regul Integr Comp Physiol 2020 Mar 01;318(3):R512-R514 PMID: 31940233 PMCID: PMC7099460 SCOPUS ID: 2-s2.0-85080850805 01/16/2020 8 Citations

Role of dopamine and selective dopamine receptor agonists on mouse ductus arteriosus tone and responsiveness. (Crockett SL, Harris M, Boatwright N, Su RL, Yarboro MT, Berger CD, Shelton EL, Reese J, Segar JL) Pediatr Res 2020 May;87(6):991-997 PMID: 31816622 PMCID: PMC7196482 SCOPUS ID: 2-s2.0-85076889181 12/10/2019 4 Citations

A physiological approach to fluid and electrolyte management of the preterm infant: Review. (Segar JL) J Neonatal Perinatal Med 2020;13(1):11-19 PMID: 31594261 SCOPUS ID: 2-s2.0-85083384284 10/09/2019 34 Citations

Effects on resident work hours, sleep duration, and work experience in a randomized order safety trial evaluating resident-physician schedules (ROSTERS). (Barger LK, Sullivan JP, Blackwell T, O'Brien CS, St Hilaire MA, Rahman SA, Phillips AJK, Qadri S, Wright KP, Segar JL, McGuire JK, Vitiello MV, de la Iglesia HO, Poynter SE, Yu PL, Zee P, Sanderson AL, Halbower AC, Lockley SW, Landrigan CP, Stone KL, Czeisler CA, ROSTERS Study Group) Sleep 2019 Aug 01;42(8) PMID: 31106381 PMCID: PMC6685326 SCOPUS ID: 2-s2.0-85071346741 05/21/2019 38 Citations

AAP recommends isotonic maintenance intravenous fluid. (Segar JL) J Pediatr 2019 May;208:294-297 PMID: 31027625 SCOPUS ID: 2-s2.0-85064319414 04/28/2019

Maintenance Intravenous Fluids. (Segar J, Brophy P) Pediatrics 2019 Apr;143(4) PMID: 30926621 SCOPUS ID: 2-s2.0-85064141591 03/31/2019 5 Citations

Race in the social-epigenomic regulation of pre- and perinatal development (Lane RH, Majnik AV, Segar JL) Nutritional Epigenomics 1 January 2019:135-152 SCOPUS ID: 2-s2.0-85123656744 01/01/2019

Fetal hyperglycemia acutely induces persistent insulin resistance in skeletal muscle. (Kua KL, Hu S, Wang C, Yao J, Dang D, Sawatzke AB, Segar JL, Wang K, Norris AW) J Endocrinol 2019 Jul 01;242(1):M1-M15 PMID: 30444716 PMCID: PMC6494731 SCOPUS ID: 2-s2.0-85068887971 11/18/2018 19 Citations

Physiological Approach to Sodium Supplementation in Preterm Infants. (Segar DE, Segar EK, Harshman LA, Dagle JM, Carlson SJ, Segar JL) Am J Perinatol 2018 Aug;35(10):994-1000 PMID: 29486497 PMCID: PMC6059989 SCOPUS ID: 2-s2.0-85042628690 02/28/2018 38 Citations

Causes and circumstances of death in a neonatal unit over 20 years. (Michel MC, Colaizy TT, Klein JM, Segar JL, Bell EF) Pediatr Res 2018 Apr;83(4):829-833 PMID: 29443114 PMCID: PMC5935571 SCOPUS ID: 2-s2.0-85046537541 02/15/2018 31 Citations

Impact of the ovarian cycle and pregnancy on plasma chemistry values in ewes. (Zywicki ME, Blohowiak SE, Magness RR, Segar JL, Kling PJ) J Vet Diagn Invest 2018 Mar;30(2):238-244 PMID: 29291683 PMCID: PMC5810928 SCOPUS ID: 2-s2.0-85041720363 01/03/2018 5 Citations

Neurohumoral and autonomic regulation of blood pressure (Segar JL) Pediatric Hypertension 1 January 2018:3-26 SCOPUS ID: 2-s2.0-85046455887 01/01/2018

Fluid and Electrolyte Management of High-Risk Infants (Segar J) Nephrology and Fluid Electrolyte Physiology Neonatology Questions and Controversies 1 January 2018:151-164 SCOPUS ID: 2-s2.0-85088778043 01/01/2018 3 Citations

Ovine uterine space restriction causes dysregulation of the renin-angiotensin system in fetal kidneys. (Kranch-Shorthouse RA, Bauer AS, Magness RR, Lopez GE, Segar JL, Blohowiak SE, Kling PJ) Biol Reprod 2017 Jan 01;96(1):211-220 PMID: 28395333 PMCID: PMC6373835 SCOPUS ID: 2-s2.0-85022323462 04/11/2017 2 Citations

Chronic kidney disease: A life course health development perspective (Brophy PD, Charlton JR, Carmody JB, Reidy KJ, Harshman L, Segar J, Askenazi D, Shoham D, Bagby SP) Handbook of Life Course Health Development 1 January 2017:375-401 SCOPUS ID: 2-s2.0-85042490269 01/01/2017 10 Citations

Neural Regulation of Blood Pressure During Fetal and Newborn Life (Segar JL, Giussani DA) Fetal and Neonatal Physiology 2 Volume Set 1 January 2017:573-584.e4 SCOPUS ID: 2-s2.0-85136031026 01/01/2017 1 Citation

Vitamin E Nutrition in the Fetus and Newborn (Segar JL, Bell EF, Johnson LH, Bhutani VK) Fetal and Neonatal Physiology 2 Volume Set 1 January 2017:326-335.e3 SCOPUS ID: 2-s2.0-85136030649 01/01/2017 1 Citation

Renal adaptive changes and sodium handling in the fetal-to-newborn transition. (Segar JL) Semin Fetal Neonatal Med 2017 Apr;22(2):76-82 PMID: 27881286 SCOPUS ID: 2-s2.0-85006868071 11/25/2016 31 Citations

Increasing fetal ovine number per gestation alters fetal plasma clinical chemistry values. (Zywicki M, Blohowiak SE, Magness RR, Segar JL, Kling PJ) Physiol Rep 2016 Aug;4(16) PMID: 27565903 PMCID: PMC5002913 SCOPUS ID: 2-s2.0-84983802421 08/28/2016 6 Citations

Advantages of Bayesian monitoring methods in deciding whether and when to stop a clinical trial: an example of a neonatal cooling trial. (Pedroza C, Tyson JE, Das A, Laptook A, Bell EF, Shankaran S, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network) Trials 2016 Jul 22;17(1):335 PMID: 27450203 PMCID: PMC4957277 SCOPUS ID: 2-s2.0-84979021974 07/28/2016 16 Citations

Neonatal growth restriction-related leptin deficiency enhances leptin-triggered sympathetic activation and central angiotensin II receptor-dependent stress-evoked hypertension. (Peotta V, Rahmouni K, Segar JL, Morgan DA, Pitz KM, Rice OM, Roghair RD) Pediatr Res 2016 Aug;80(2):244-51 PMID: 27049292 PMCID: PMC4990468 SCOPUS ID: 2-s2.0-84983262241 04/07/2016 5 Citations

Maternal Hyperglycemia Directly and Rapidly Induces Cardiac Septal Overgrowth in Fetal Rats. (Gordon EE, Reinking BE, Hu S, Yao J, Kua KL, Younes AK, Wang C, Segar JL, Norris AW) J Diabetes Res 2015;2015:479565 PMID: 26064981 PMCID: PMC4439465 SCOPUS ID: 2-s2.0-84929629706 06/13/2015 33 Citations

ANG II modulation of cardiac growth and remodeling in immature fetal sheep. (Sandgren J, Scholz TD, Segar JL) Am J Physiol Regul Integr Comp Physiol 2015 Jun 01;308(11):R965-72 PMID: 25810382 PMCID: PMC4451391 SCOPUS ID: 2-s2.0-84930898311 03/27/2015 8 Citations

Early-life course socioeconomic factors and chronic kidney disease. (Brophy PD, Shoham DA, CKD Life Course Group, Charlton JR, Carmody J, Reidy KJ, Harshman L, Segar J, Askenazi D) Adv Chronic Kidney Dis 2015 Jan;22(1):16-23 PMID: 25573508 SCOPUS ID: 2-s2.0-84920263374 01/13/2015 35 Citations

Effect of depth and duration of cooling on deaths in the NICU among neonates with hypoxic ischemic encephalopathy: a randomized clinical trial. (Shankaran S, Laptook AR, Pappas A, McDonald SA, Das A, Tyson JE, Poindexter BB, Schibler K, Bell EF, Heyne RJ, Pedroza C, Bara R, Van Meurs KP, Grisby C, Huitema CM, Garg M, Ehrenkranz RA, Shepherd EG, Chalak LF, Hamrick SE, Khan AM, Reynolds AM, Laughon MM, Truog WE, Dysart KC, Carlo WA, Walsh MC, Watterberg KL, Higgins RD, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network) JAMA 2014 Dec 24-31;312(24):2629-39 PMID: 25536254 PMCID: PMC4335311 SCOPUS ID: 2-s2.0-84919973340 12/24/2014 269 Citations

Hyperglycemia induces embryopathy, even in the absence of systemic maternal diabetes: an in vivo test of the fuel mediated teratogenesis hypothesis. (Baack ML, Wang C, Hu S, Segar JL, Norris AW) Reprod Toxicol 2014 Jul;46:129-36 PMID: 24721120 PMCID: PMC4067982 SCOPUS ID: 2-s2.0-84899792366 04/12/2014 34 Citations

Angiotensin II-induced cardiovascular load regulates cardiac remodeling and related gene expression in late-gestation fetal sheep. (Norris AW, Bahr TM, Scholz TD, Peterson ES, Volk KA, Segar JL) Pediatr Res 2014 Jun;75(6):689-696 PMID: 24614802 PMCID: PMC4251591 SCOPUS ID: 2-s2.0-84900872345 03/13/2014 9 Citations

Genotype-specific alterations in vascular smooth muscle cell function in cystic fibrosis piglets. (Guo JJ, Stoltz DA, Zhu V, Volk KA, Segar JL, McCray PB Jr, Roghair RD) J Cyst Fibros 2014 May;13(3):251-9 PMID: 24183914 PMCID: PMC3972271 SCOPUS ID: 2-s2.0-84897111753 11/05/2013 23 Citations

Urinary metabolomic markers of aminoglycoside nephrotoxicity in newborn rats. (Hanna MH, Segar JL, Teesch LM, Kasper DC, Schaefer FS, Brophy PD) Pediatr Res 2013 May;73(5):585-91 PMID: 23411940 PMCID: PMC3640567 SCOPUS ID: 2-s2.0-84878301277 02/16/2013 40 Citations

Neurohumoral and autonomic regulation of blood pressure (Segar JL) Pediatric Hypertension Third Edition 1 January 2013:3-23 SCOPUS ID: 2-s2.0-85032831055 01/01/2013

Thyroid hormone is required for growth adaptation to pressure load in the ovine fetal heart. (Segar JL, Volk KA, Lipman MH, Scholz TD) Exp Physiol 2013 Mar;98(3):722-33 PMID: 23104936 PMCID: PMC3578172 SCOPUS ID: 2-s2.0-84874118285 10/30/2012 30 Citations

Impact of maternal dexamethasone on coronary PGE(2) production and prostaglandin-dependent coronary reactivity. (Roghair RD, Volk KA, Lamb FS, Segar JL) Am J Physiol Regul Integr Comp Physiol 2012 Sep 01;303(5):R513-9 PMID: 22832534 PMCID: PMC3468415 SCOPUS ID: 2-s2.0-84865712156 07/27/2012 3 Citations

Sex-specific programming of hypertension in offspring of late-gestation diabetic rats. (Katkhuda R, Peterson ES, Roghair RD, Norris AW, Scholz TD, Segar JL) Pediatr Res 2012 Oct;72(4):352-61 PMID: 22805998 PMCID: PMC3607358 SCOPUS ID: 2-s2.0-84867047874 07/19/2012 36 Citations

Maternal Hyperglycemia Disrupts Histone 3 Lysine 36 Trimethylation of the IGF-1 Gene. (Zinkhan EK, Fu Q, Wang Y, Yu X, Callaway CW, Segar JL, Scholz TD, McKnight RA, Joss-Moore L, Lane RH) J Nutr Metab 2012;2012:930364 PMID: 22548154 PMCID: PMC3324902 SCOPUS ID: 2-s2.0-84873863044 05/02/2012 31 Citations

Neonatal diuretic therapy: furosemide, thiazides, and spironolactone. (Segar JL) Clin Perinatol 2012 Mar;39(1):209-20 PMID: 22341547 SCOPUS ID: 2-s2.0-84857085333 02/22/2012 51 Citations

Maternal antioxidant blocks programmed cardiovascular and behavioural stress responses in adult mice. (Roghair RD, Wemmie JA, Volk KA, Scholz TD, Lamb FS, Segar JL) Clin Sci (Lond) 2011 Nov;121(10):427-36 PMID: 21615331 PMCID: PMC3677964 SCOPUS ID: 2-s2.0-80052368572 05/28/2011 28 Citations

Programming of adult cardiovascular disease following exposure to late-gestation hyperglycemia. (Agoudemos M, Reinking BE, Koppenhafer SL, Segar JL, Scholz TD) Neonatology 2011;100(2):198-205 PMID: 21455011 PMCID: PMC3085032 SCOPUS ID: 2-s2.0-79953190814 04/02/2011 21 Citations

Transfusion effects on cardiomyocyte growth and proliferation in fetal sheep after chronic anemia. (Jonker SS, Scholz TD, Segar JL) Pediatr Res 2011 Jun;69(6):485-90 PMID: 21386752 PMCID: PMC3090539 SCOPUS ID: 2-s2.0-79955858176 03/10/2011 17 Citations

The effect of adrenalectomy on the cardiac response to subacute fetal anemia. (Jonker SS, Scholz TD, Segar JL) Can J Physiol Pharmacol 2011 Feb;89(2):79-88 PMID: 21326338 PMCID: PMC3097906 SCOPUS ID: 2-s2.0-79953103129 02/18/2011 9 Citations

Neural Regulation of Blood Pressure During Fetal and Newborn Life (Segar JL) Fetal and Neonatal Physiology E Book Fourth Edition 1 January 2011:789-798 SCOPUS ID: 2-s2.0-85153840683 01/01/2011 1 Citation

Effect of insulin and dexamethasone on fetal assimilation of maternal glucose. (Norris AW, Wang C, Yao J, Walsh SA, Sawatzke AB, Hu S, Sunderland JJ, Segar JL, Ponto LL) Endocrinology 2011 Jan;152(1):255-62 PMID: 21084442 PMCID: PMC3219051 SCOPUS ID: 2-s2.0-78650847598 11/19/2010 16 Citations

Localized fetomaternal hyperglycemia: spatial and kinetic definition by positron emission tomography. (Yao J, Wang C, Walsh SA, Hu S, Sawatzke AB, Dang D, Segar JL, Ponto LL, Sunderland JJ, Norris AW) PLoS One 2010 Aug 06;5(8):e12027 PMID: 20700464 PMCID: PMC2917372 SCOPUS ID: 2-s2.0-77957761086 08/12/2010 10 Citations

Coronary endothelial function and vascular smooth muscle proliferation are programmed by early-gestation dexamethasone exposure in sheep. (Volk KA, Roghair RD, Jung F, Scholz TD, Lamb FS, Segar JL) Am J Physiol Regul Integr Comp Physiol 2010 Jun;298(6):R1607-14 PMID: 20335378 PMCID: PMC2886704 SCOPUS ID: 2-s2.0-77952719685 03/26/2010 5 Citations

Cardiomyopathy in offspring of diabetic rats is associated with activation of the MAPK and apoptotic pathways. (Reinking BE, Wedemeyer EW, Weiss RM, Segar JL, Scholz TD) Cardiovasc Diabetol 2009 Jul 31;8:43 PMID: 19646268 PMCID: PMC2731081 SCOPUS ID: 2-s2.0-69549124202 08/04/2009 33 Citations

Programming of growth, insulin resistance and vascular dysfunction in offspring of late gestation diabetic rats. (Segar EM, Norris AW, Yao JR, Hu S, Koppenhafer SL, Roghair RD, Segar JL, Scholz TD) Clin Sci (Lond) 2009 Jul 02;117(3):129-38 PMID: 19203348 PMCID: PMC2884292 SCOPUS ID: 2-s2.0-70149105947 02/11/2009 40 Citations

Vascular nitric oxide and superoxide anion contribute to sex-specific programmed cardiovascular physiology in mice. (Roghair RD, Segar JL, Volk KA, Chapleau MW, Dallas LM, Sorenson AR, Scholz TD, Lamb FS) Am J Physiol Regul Integr Comp Physiol 2009 Mar;296(3):R651-62 PMID: 19144750 PMCID: PMC2665850 SCOPUS ID: 2-s2.0-64149128615 01/16/2009 44 Citations

Fetal programming alters reactive oxygen species production in sheep cardiac mitochondria. (von Bergen NH, Koppenhafer SL, Spitz DR, Volk KA, Patel SS, Roghair RD, Lamb FS, Segar JL, Scholz TD) Clin Sci (Lond) 2009 Apr;116(8):659-68 PMID: 19032144 PMCID: PMC3677965 SCOPUS ID: 2-s2.0-66949132569 11/27/2008 19 Citations

Influence of early life events on health and diseases. (Robillard JE, Segar JL) Trans Am Clin Climatol Assoc 2006;117:313-9; discussion 319-20 PMID: 18528483 PMCID: PMC1500933 SCOPUS ID: 2-s2.0-63449140550 06/06/2008 12 Citations

Coronary constriction to angiotensin II is enhanced by endothelial superoxide production in sheep programmed by dexamethasone. (Roghair RD, Miller FJ Jr, Scholz TD, Lamb FS, Segar JL) Pediatr Res 2008 Apr;63(4):370-4 PMID: 18356741 PMCID: PMC3663587 SCOPUS ID: 2-s2.0-41349121008 03/22/2008 10 Citations

Cardiac metabolism in the fetus and newborn (Scholz TD, Segar JL) Neoreviews March 2008;9(3):e109-e118 SCOPUS ID: 2-s2.0-42449110942 03/01/2008 5 Citations

Activation of the mitogen-activated protein kinases and Akt in response to pulmonary artery banding in the fetal sheep heart is developmentally regulated. (Olson AK, Protheroe KN, Scholz TD, Segar JL) Neonatology 2008;93(3):145-52 PMID: 17878740 SCOPUS ID: 2-s2.0-41349108091 09/20/2007 6 Citations

Murine aortic reactivity is programmed equally by maternal low protein diet or late gestation dexamethasone. (Roghair RD, Segar JL, Kilpatrick RA, Segar EM, Scholz TD, Lamb FS) J Matern Fetal Neonatal Med 2007 Nov;20(11):833-41 PMID: 17853187 SCOPUS ID: 2-s2.0-35349015382 09/14/2007 15 Citations

Endothelial superoxide production is altered in sheep programmed by early gestation dexamethasone exposure. (Roghair RD, Miller FJ Jr, Scholz TD, Lamb FS, Segar JL) Neonatology 2008;93(1):19-27 PMID: 17630494 SCOPUS ID: 2-s2.0-37249072735 07/17/2007 22 Citations

Increased erythropoietin elimination in fetal sheep following chronic phlebotomy. (Freise KJ, Widness JA, Segar JL, Schmidt RL, Veng-Pedersen P) Pharm Res 2007 Sep;24(9):1653-9 PMID: 17457660 PMCID: PMC2863314 SCOPUS ID: 2-s2.0-34547613348 04/26/2007 7 Citations

Early gestation dexamethasone alters baroreflex and vascular responses in newborn lambs before hypertension. (Segar JL, Roghair RD, Segar EM, Bailey MC, Scholz TD, Lamb FS) Am J Physiol Regul Integr Comp Physiol 2006 Aug;291(2):R481-8 PMID: 16914435 SCOPUS ID: 2-s2.0-33745806160 08/18/2006 38 Citations

The mitogen-activated protein kinases and Akt are developmentally regulated in the chronically anemic fetal sheep heart. (Olson AK, Protheroe KN, Scholz TD, Segar JL) J Soc Gynecol Investig 2006 Apr;13(3):157-65 PMID: 16638585 SCOPUS ID: 2-s2.0-33646109563 04/28/2006 12 Citations

Mitogen-activated protein kinase activation and regulation in the pressure-loaded fetal ovine heart. (Olson AK, Protheroe KN, Segar JL, Scholz TD) Am J Physiol Heart Circ Physiol 2006 Apr;290(4):H1587-95 PMID: 16299265 SCOPUS ID: 2-s2.0-33646075734 11/22/2005 15 Citations

Regulation of myocardial glucose transporters GLUT1 and GLUT4 in chronically anemic fetal lambs. (Ralphe JC, Nau PN, Mascio CE, Segar JL, Scholz TD) Pediatr Res 2005 Oct;58(4):713-8 PMID: 16189198 SCOPUS ID: 2-s2.0-25444431713 09/29/2005 15 Citations

Myocardial vascular and metabolic adaptations in chronically anemic fetal sheep. (Mascio CE, Olison AK, Ralphe JC, Tomanek RJ, Scholz TD, Segar JL) Am J Physiol Regul Integr Comp Physiol 2005 Dec;289(6):R1736-45 PMID: 16123231 SCOPUS ID: 2-s2.0-27844563117 08/27/2005 27 Citations

Newborn lamb coronary artery reactivity is programmed by early gestation dexamethasone before the onset of systemic hypertension. (Roghair RD, Segar JL, Sharma RV, Zimmerman MC, Jagadeesha DK, Segar EM, Scholz TD, Lamb FS) Am J Physiol Regul Integr Comp Physiol 2005 Oct;289(4):R1169-76 PMID: 15961529 PMCID: PMC2730218 SCOPUS ID: 2-s2.0-25844444648 06/18/2005 34 Citations

Correlation between myocardial malate/aspartate shuttle activity and EAAT1 protein expression in hyper- and hypothyroidism. (Ralphe JC, Bedell K, Segar JL, Scholz TD) Am J Physiol Heart Circ Physiol 2005 May;288(5):H2521-6 PMID: 15615843 SCOPUS ID: 2-s2.0-18044364838 12/24/2004 25 Citations

Ontogeny of vascular growth factors in perinatal sheep myocardium. (van Natta TL, Ralphe JC, Mascio CE, Bedell KA, Scholz TD, Segar JL) J Soc Gynecol Investig 2004 Dec;11(8):503-10 PMID: 15582494 SCOPUS ID: 2-s2.0-9744234403 12/08/2004 3 Citations

Effects of cortisol on cardiac myocytes and on expression of cardiac genes in fetal sheep. (Lumbers ER, Boyce AC, Joulianos G, Kumarasamy V, Barner E, Segar JL, Burrell JH) Am J Physiol Regul Integr Comp Physiol 2005 Mar;288(3):R567-74 PMID: 15576665 SCOPUS ID: 2-s2.0-13844250260 12/04/2004 76 Citations

Apoptosis-related mitochondrial dysfunction in the early postoperative neonatal lamb heart. (Caldarone CA, Barner EW, Wang L, Karimi M, Mascio CE, Hammel JM, Segar JL, Du C, Scholz TD) Ann Thorac Surg 2004 Sep;78(3):948-55 PMID: 15337026 SCOPUS ID: 2-s2.0-4444367200 09/01/2004 25 Citations

Localization and function of the brain excitatory amino acid transporter type 1 in cardiac mitochondria. (Ralphe JC, Segar JL, Schutte BC, Scholz TD) J Mol Cell Cardiol 2004 Jul;37(1):33-41 PMID: 15242733 SCOPUS ID: 2-s2.0-3142617875 07/10/2004 44 Citations

Early gestation dexamethasone programs enhanced postnatal ovine coronary artery vascular reactivity. (Roghair RD, Lamb FS, Miller FJ Jr, Scholz TD, Segar JL) Am J Physiol Regul Integr Comp Physiol 2005 Jan;288(1):R46-53 PMID: 15217789 SCOPUS ID: 2-s2.0-11144254396 06/26/2004 36 Citations

Neonatal vulnerability to ischemia and reperfusion: Cardioplegic arrest causes greater myocardial apoptosis in neonatal lambs than in mature lambs. (Karimi M, Wang LX, Hammel JM, Mascio CE, Abdulhamid M, Barner EW, Scholz TD, Segar JL, Li WG, Niles SD, Caldarone CA) J Thorac Cardiovasc Surg 2004 Feb;127(2):490-7 PMID: 14762359 SCOPUS ID: 2-s2.0-10744225976 02/06/2004 42 Citations

Neural Regulation of Blood Pressure During Fetal and Newborn Life (Segar JL) Fetal and Neonatal Physiology Third Edition December 01, 2003;1-2:717-726 SCOPUS ID: 2-s2.0-84911100093 12/01/2003 4 Citations

Late-gestation betamethasone enhances coronary artery responsiveness to angiotensin II in fetal sheep. (Roghair RD, Lamb FS, Bedell KA, Smith OM, Scholz TD, Segar JL) Am J Physiol Regul Integr Comp Physiol 2004 Jan;286(1):R80-8 PMID: 14512274 SCOPUS ID: 2-s2.0-0346096880 09/27/2003 23 Citations

Myocardial apoptosis after cardioplegic arrest in the neonatal lamb. (Hammel JM, Caldarone CA, Van Natta TL, Wang LX, Welke KF, Li W, Niles S, Barner E, Scholz TD, Behrendt DM, Segar JL) J Thorac Cardiovasc Surg 2003 Jun;125(6):1268-75 PMID: 12830043 SCOPUS ID: 2-s2.0-0037973476 06/28/2003 15 Citations

Inhibition of sympathetic responses at birth in sheep by lesion of the paraventricular nucleus. (Segar JL, Ellsbury DL, Smith OM) Am J Physiol Regul Integr Comp Physiol 2002 Dec;283(6):R1395-403 PMID: 12388455 SCOPUS ID: 2-s2.0-0036889028 10/22/2002 14 Citations

Metabolic adaptation of the fetal and postnatal ovine heart: regulatory role of hypoxia-inducible factors and nuclear respiratory factor-1. (Nau PN, Van Natta T, Ralphe JC, Teneyck CJ, Bedell KA, Caldarone CA, Segar JL, Scholz TD) Pediatr Res 2002 Aug;52(2):269-78 PMID: 12149506 SCOPUS ID: 2-s2.0-85047682703 08/01/2002 49 Citations

Effects of fetal ovine adrenalectomy on sympathetic and baroreflex responses at birth. (Segar JL, Van Natta T, Smith OJ) Am J Physiol Regul Integr Comp Physiol 2002 Aug;283(2):R460-7 PMID: 12121859 SCOPUS ID: 2-s2.0-0036340398 07/18/2002 15 Citations

Optimization of high-frequency oscillatory ventilation for the treatment of experimental pneumothorax. (Ellsbury DL, Klein JM, Segar JL) Crit Care Med 2002 May;30(5):1131-5 PMID: 12006814 SCOPUS ID: 2-s2.0-0036251230 05/15/2002 26 Citations

Effects of gestational age on myocardial blood flow and coronary flow reserve in pressure-loaded ovine fetal hearts. (Dalshaug GB, Scholz TD, Smith OM, Bedell KA, Caldarone CA, Segar JL) Am J Physiol Heart Circ Physiol 2002 Apr;282(4):H1359-69 PMID: 11893572 SCOPUS ID: 2-s2.0-0036081425 03/15/2002 18 Citations

Angiotensin II in cardiac pressure-overload hypertrophy in fetal sheep. (Segar JL, Dalshaug GB, Bedell KA, Smith OM, Scholz TD) Am J Physiol Regul Integr Comp Physiol 2001 Dec;281(6):R2037-47 PMID: 11705791 SCOPUS ID: 2-s2.0-0035658522 11/14/2001 31 Citations

Responses of fetal ovine systemic and umbilical arteries to angiotensin II. (Segar JL, Barna TJ, Acarregui MJ, Lamb FS) Pediatr Res 2001 Jun;49(6):826-33 PMID: 11385145 SCOPUS ID: 2-s2.0-0034983354 06/01/2001 17 Citations

Glucocorticoid modulation of cardiovascular and autonomic function in preterm lambs: role of ANG II. (Segar JL, Bedell KA, Smith OJ) Am J Physiol Regul Integr Comp Physiol 2001 Mar;280(3):R646-54 PMID: 11171641 SCOPUS ID: 2-s2.0-0034992429 02/15/2001 37 Citations

Autonomic adjustments to severe hypotension in fetal and neonatal sheep. (Nuyt AM, Segar JL, Holley AT, Robillard JE) Pediatr Res 2001 Jan;49(1):56-62 PMID: 11134492 SCOPUS ID: 2-s2.0-0035200489 01/03/2001 12 Citations

Metabolic adaptation of the hypertrophied heart: role of the malate/aspartate and alpha-glycerophosphate shuttles. (Rupert BE, Segar JL, Schutte BC, Scholz TD) J Mol Cell Cardiol 2000 Dec;32(12):2287-97 PMID: 11113004 SCOPUS ID: 2-s2.0-0034509885 12/13/2000 36 Citations

Sympathetic responses to cardiopulmonary vagal afferent stimulation during development. (Merrill DC, Segar JL, McWeeny OJ, Robillard JE) Am J Physiol 1999 Oct;277(4):H1311-6 PMID: 10516165 SCOPUS ID: 2-s2.0-0032753525 10/12/1999 17 Citations

Mechano- and chemoreceptor modulation of renal sympathetic nerve activity at birth in fetal sheep. (Segar JL, Smith OJ, Holley AT) Am J Physiol 1999 May;276(5):R1295-301 PMID: 10233019 SCOPUS ID: 2-s2.0-0033007121 05/08/1999 7 Citations

Development of baroreflex influences on heart rate variability in preterm infants. (Mazursky JE, Birkett CL, Bedell KA, Ben-Haim SA, Segar JL) Early Hum Dev 1998 Nov;53(1):37-52 PMID: 10193925 SCOPUS ID: 2-s2.0-0031785737 04/08/1999 48 Citations

Reply. (George TN, Segar JL) J Pediatr 1999 Mar;134(3):383-4 PMID: 10064690 03/11/1999

NO effect on hemostasis. (Cheung PY, Etches PC, Radomski MW) J Pediatr 1999 Mar;134(3):383-4 PMID: 10064685 SCOPUS ID: 2-s2.0-0033091370 03/04/1999 2 Citations

Ontogeny and regulation of cardiac angiotensin types 1 and 2 receptors during fetal life in sheep. (Samyn ME, Petershack JA, Bedell KA, Mathews MS, Segar JL) Pediatr Res 1998 Sep;44(3):323-9 PMID: 9727708 SCOPUS ID: 2-s2.0-0031817078 09/04/1998 27 Citations

The effect of inhaled nitric oxide therapy on bleeding time and platelet aggregation in neonates. (George TN, Johnson KJ, Bates JN, Segar JL) J Pediatr 1998 Apr;132(4):731-4 PMID: 9580780 SCOPUS ID: 2-s2.0-0031925241 05/15/1998 90 Citations

Effect of antenatal glucocorticoids on sympathetic nerve activity at birth in preterm sheep. (Segar JL, Lumbers ER, Nuyt AM, Smith OJ, Robillard JE) Am J Physiol 1998 Jan;274(1):R160-7 PMID: 9458913 SCOPUS ID: 2-s2.0-0031915717 02/12/1998 59 Citations

Angiotensin AT1 receptor blockade fails to attenuate pressure-overload cardiac hypertrophy in fetal sheep. (Segar JL, Scholz TD, Bedell KA, Smith OM, Huss DJ, Guillery EN) Am J Physiol 1997 Oct;273(4):R1501-8 PMID: 9362317 SCOPUS ID: 2-s2.0-0030667188 11/15/1997 38 Citations

Ontogeny of the arterial and cardiopulmonary baroreflex during fetal and postnatal life. (Segar JL) Am J Physiol 1997 Aug;273(2 Pt 2):R457-71 PMID: 9277527 SCOPUS ID: 2-s2.0-0030827717 08/01/1997 82 Citations

Role of endogenous ANG II and AT1 receptors in regulating arterial baroreflex responses in newborn lambs. (Segar JL, Minnick A, Nuyt AM, Robillard JE) Am J Physiol 1997 Jun;272(6 Pt 2):R1862-73 PMID: 9227601 SCOPUS ID: 2-s2.0-0030787054 06/01/1997 28 Citations

Changes in body water compartments with diuretic therapy in infants with chronic lung disease. (Segar JL, Chemtob S, Bell EF) Early Hum Dev 1997 Apr 25;48(1-2):99-107 PMID: 9131311 SCOPUS ID: 2-s2.0-0030908949 04/25/1997 16 Citations

Arginine vasopressin modulation of arterial baroreflex responses in fetal and newborn sheep. (Nuyt AM, Segar JL, Holley AT, O'Mara MS, Chapleau MW, Robillard JE) Am J Physiol 1996 Dec;271(6 Pt 2):R1643-53 PMID: 8997365 SCOPUS ID: 2-s2.0-0030459732 12/01/1996 18 Citations

Regulation of renal sympathetic nerve activity at birth. (Mazursky JE, Segar JL, Nuyt AM, Smith BA, Robillard JE) Am J Physiol 1996 Jan;270(1 Pt 2):R86-93 PMID: 8769788 SCOPUS ID: 2-s2.0-0030029867 01/01/1996 18 Citations

Differential gene expression and regulation of renal angiotensin II receptor subtypes (AT1 and AT2) during fetal life in sheep. (Robillard JE, Page WV, Mathews MS, Schutte BC, Nuyt AM, Segar JL) Pediatr Res 1995 Dec;38(6):896-904 PMID: 8618791 SCOPUS ID: 2-s2.0-0028884264 12/01/1995 58 Citations

Effect of cortisol on gene expression of the renin-angiotensin system in fetal sheep. (Segar JL, Bedell K, Page WV, Mazursky JE, Nuyt AM, Robillard JE) Pediatr Res 1995 Jun;37(6):741-6 PMID: 7651758 SCOPUS ID: 2-s2.0-0029038179 06/01/1995 68 Citations

Impairment of cardiopulmonary baroreflexes during the newborn period. (Merrill DC, McWeeny OJ, Segar JL, Robillard JE) Am J Physiol 1995 Mar;268(3 Pt 2):H1343-51 PMID: 7900887 SCOPUS ID: 2-s2.0-0028923362 03/01/1995 14 Citations

Ontogenic changes and regulation of renal angiotensin II type 1 receptor gene expression during fetal and newborn life. (Robillard JE, Schutte BC, Page WV, Fedderson JA, Porter CC, Segar JL) Pediatr Res 1994 Dec;36(6):755-62 PMID: 7898984 SCOPUS ID: 2-s2.0-0028127366 12/01/1994 45 Citations

Changes in ovine renal sympathetic nerve activity and baroreflex function at birth. (Segar JL, Mazursky JE, Robillard JE) Am J Physiol 1994 Nov;267(5 Pt 2):H1824-32 PMID: 7977812 SCOPUS ID: 2-s2.0-0028112927 11/01/1994 52 Citations

Ontogenic changes in renal response to alpha 1-adrenoceptor stimulation in sheep. (Guillery EN, Segar JL, Merrill DC, Nakamura KT, Jose PA, Robillard JE) Am J Physiol 1994 Oct;267(4 Pt 2):R990-8 PMID: 7943440 SCOPUS ID: 2-s2.0-0028115462 10/01/1994 15 Citations

Cardiopulmonary and arterial baroreflex responses to acute volume expansion during fetal and postnatal development. (Merrill DC, Segar JL, McWeeny OJ, Smith BA, Robillard JE) Am J Physiol 1994 Oct;267(4 Pt 2):H1467-75 PMID: 7943393 SCOPUS ID: 2-s2.0-0028063270 10/01/1994 11 Citations

Role of sympathetic activity in the generation of heart rate and arterial pressure variability in fetal sheep. (Segar JL, Merrill DC, Smith BA, Robillard JE) Pediatr Res 1994 Feb;35(2):250-4 PMID: 8165062 SCOPUS ID: 2-s2.0-0028013450 02/01/1994 24 Citations

Role of endogenous ANG II on resetting arterial baroreflex during development. (Segar JL, Merrill DC, Robillard JE) Am J Physiol 1994 Jan;266(1 Pt 2):H52-9 PMID: 8304523 SCOPUS ID: 2-s2.0-0028002794 01/01/1994 34 Citations

Influence of renal nerves on renal function during development. (Robillard JE, Guillery EN, Segar JL, Merrill DC, Jose PA) Pediatr Nephrol 1993 Oct;7(5):667-71 PMID: 8251342 SCOPUS ID: 2-s2.0-0027359276 10/01/1993 16 Citations

Hemodynamic changes during endotracheal suctioning are mediated by increased autonomic activity. (Segar JL, Merrill DC, Chapleau MW, Robillard JE) Pediatr Res 1993 Jun;33(6):649-52 PMID: 8378127 SCOPUS ID: 2-s2.0-0027280731 06/01/1993 22 Citations

Indomethacin compromises hemodynamics during positive-pressure ventilation, independently of prostanoids. (Malcolm DD, Segar JL, Robillard JE, Chemtob S) J Appl Physiol (1985) 1993 Apr;74(4):1672-8 PMID: 8514682 SCOPUS ID: 2-s2.0-0027153132 04/01/1993 44 Citations

Ontogeny of baroreflex control of renal sympathetic nerve activity and heart rate. (Segar JL, Hajduczok G, Smith BA, Merrill DC, Robillard JE) Am J Physiol 1992 Dec;263(6 Pt 2):H1819-26 PMID: 1481906 SCOPUS ID: 2-s2.0-0027093660 12/01/1992 63 Citations

Ontogeny of renal response to specific dopamine DA1-receptor stimulation in sheep. (Segar JL, Smith FG, Guillery EN, Jose PA, Robillard JE) Am J Physiol 1992 Oct;263(4 Pt 2):R868-73 PMID: 1357989 SCOPUS ID: 2-s2.0-0026793871 10/01/1992 17 Citations

Addition of metolazone to overcome tolerance to furosemide in infants with bronchopulmonary dysplasia. (Segar JL, Robillard JE, Johnson KJ, Bell EF, Chemtob S) J Pediatr 1992 Jun;120(6):966-73 PMID: 1593359 SCOPUS ID: 2-s2.0-0026545139 06/01/1992 40 Citations

Regulation of sodium metabolism and extracellular fluid volume during development. (Robillard JE, Segar JL, Smith FG, Jose PA) Clin Perinatol 1992 Mar;19(1):15-31 PMID: 1533579 SCOPUS ID: 2-s2.0-0026605114 03/01/1992 23 Citations

Mechanisms regulating renal sodium excretion during development. (Robillard JE, Smith FG, Segar JL, Guillery EN, Jose PA) Pediatr Nephrol 1992 Mar;6(2):205-13 PMID: 1533309 SCOPUS ID: 2-s2.0-0026532935 03/01/1992 43 Citations

Renal nerves modulate kidney renin gene expression during the transition from fetal to newborn life. (Page WV, Perlman S, Smith FG, Segar JL, Robillard JE) Am J Physiol 1992 Mar;262(3 Pt 2):R459-63 PMID: 1373041 SCOPUS ID: 2-s2.0-0026607252 03/01/1992 39 Citations

Endocrine effects of ventilation, oxygenation and cord occlusion in near-term fetal sheep. (Smith FG, Smith BA, Segar JL, Robillard JE) J Dev Physiol 1991 Mar;15(3):133-8 PMID: 1834728 SCOPUS ID: 2-s2.0-0025900550 03/01/1991 12 Citations

Neural control of renal hemodynamics and function during development. (Robillard JE, Smith FG, Nakamura KT, Sato T, Segar J, Jose PA) Pediatr Nephrol 1990 Jul;4(4):436-41 PMID: 2206914 SCOPUS ID: 2-s2.0-0025050881 07/01/1990 12 Citations

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Profiles for MCW, MU, MSOE, UWM, BCW, CW, Froedtert, and VA Faculty

Jeffrey L. Segar MD

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Publications (172)