Medical College of Wisconsin
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Wade M. Mueller MD

Wade M. Mueller MD


Institution: Medical College of Wisconsin
Department: Neurosurgery
Program: Adult

Member of the Cancer Center
Member of the Neuroscience Research Center


  • Identification of radiation responsive genes and transcriptome profiling via complete RNA sequencing in a stable radioresistant U87 glioblastoma model. (Doan NB, Nguyen HS, Alhajala HS, Jaber B, Al-Gizawiy MM, Ahn EE, Mueller WM, Chitambar CR, Mirza SP, Schmainda KM) Oncotarget 2018 May 04;9(34):23532-23542 PMID: 29805753 PMCID: PMC5955095 05/29/2018    
  • A Novel Application of the Integra Camino Bolt for the Drainage of Chronic Subdural Hematoma: A Technical Note. (Doan NB, Nguyen H, Janich K, Montoure A, Mohit P, Shabani S, Gelsomino M, Mueller WM, Kurpad S) Asian J Neurosurg 2018 Apr-Jun;13(2):380-382 PMID: 29682038 PMCID: PMC5898109 04/24/2018    
  • Acid ceramidase and its inhibitors: a drug target and a new class of drugs for killing glioblastoma cancer stem cells with high efficiency. (Doan NB, Alhajala H, Al-Gizawiy MM, Mueller WM, Rand SD, Connelly JM, Cochran EJ, Chitambar CR, Clark P, Kuo J, Schmainda KM, Mirza SP) Oncotarget 2017 Dec 22;8(68):112662-112674 PMID: 29348854 PMCID: PMC5762539 01/20/2018    
  • Spatial discrimination of glioblastoma and treatment effect with histologically-validated perfusion and diffusion magnetic resonance imaging metrics. (Prah MA, Al-Gizawiy MM, Mueller WM, Cochran EJ, Hoffmann RG, Connelly JM, Schmainda KM) J Neurooncol 2018 Jan;136(1):13-21 PMID: 28900832 PMCID: PMC5756123 09/14/2017       3 Citations
  • Acid ceramidase confers radioresistance to glioblastoma cells. (Doan NB, Nguyen HS, Al-Gizawiy MM, Mueller WM, Sabbadini RA, Rand SD, Connelly JM, Chitambar CR, Schmainda KM, Mirza SP) Oncol Rep 2017 Oct;38(4):1932-1940 PMID: 28765947 PMCID: PMC5652937 08/03/2017       6 Citations
  • Acid ceramidase is a novel drug target for pediatric brain tumors. (Doan NB, Nguyen HS, Montoure A, Al-Gizawiy MM, Mueller WM, Kurpad S, Rand SD, Connelly JM, Chitambar CR, Schmainda KM, Mirza SP) Oncotarget 2017 Apr 11;8(15):24753-24761 PMID: 28445970 PMCID: PMC5421885 04/28/2017    
  • Hemorrhagic Complications Associated with Ventriculostomy in Patients Undergoing Endovascular Treatment for Intracranial Aneurysms: A Single-Center Experience. (Leschke JM, Lozen A, Kaushal M, Oni-Orisan A, Noufal M, Zaidat O, Pollock GA, Mueller WM) Neurocrit Care 2017 Aug;27(1):11-16 PMID: 28000128 12/22/2016       4 Citations
  • Clinical Significance of Updated MRI Simulation Versus Immediate Postoperative MRI for Radiation Treatment Planning in Patients With Glioblastoma: Changes in FLAIR Signal. (Dayal A, Siker ML, Firat S, Bovi JA, Schultz CJ, Mueller WM, Connelly JM, Rand SD) Int J Radiat Oncol Biol Phys 2016 Oct 1;96(2S):E103 PMID: 27673785 09/28/2016    
  • Pulsed Reduced Dose Rate Reirradiation (PRDR) Using Modulated Arc (mARC) Intensity Modulated Radiation Therapy for Recurrent Gliomas: Initial Clinical Outcomes of a Novel Technique. (Siker ML, Firat S, Prah D, Schultz CJ, Dayal A, Masterson C, Connelly JM, Mueller WM, Bovi JA) Int J Radiat Oncol Biol Phys 2016 Oct 1;96(2S):E125-E126 PMID: 27673841 09/28/2016    
  • Progressing Bevacizumab-Induced Diffusion Restriction Is Associated with Coagulative Necrosis Surrounded by Viable Tumor and Decreased Overall Survival in Patients with Recurrent Glioblastoma. (Nguyen HS, Milbach N, Hurrell SL, Cochran E, Connelly J, Bovi JA, Schultz CJ, Mueller WM, Rand SD, Schmainda KM, LaViolette PS) AJNR Am J Neuroradiol 2016 12;37(12):2201-2208 PMID: 27492073 PMCID: PMC5161572 08/06/2016       14 Citations
  • Good outcomes in a patient with a Duret hemorrhage from an acute subdural hematoma. (Nguyen HS, Doan NB, Gelsomino MJ, Shabani S, Mueller WM) Int Med Case Rep J 2016;9:15-8 PMID: 26869816 PMCID: PMC4734784 02/13/2016    
  • Use of a Dermal Regeneration Template in Complicated Craniotomy Wounds: Review of a Series. (LoGiudice JA, Thayer J, Hoyt AT, Mueller WM) Oper Neurosurg (Hagerstown) 2015 Dec 01;11(4):545-553 PMID: 29506168 12/01/2015    
  • Use of a Dermal Regeneration Template in Complicated Craniotomy Wounds: Review of a Series. (LoGiudice JA, Thayer J, Hoyt A, Mueller WM) Neurosurgery 2015 Aug 14: PMID: 26280115 08/19/2015    
  • Imaging of the Functional and Dysfunctional Visual System. (DeYoe EA, Ulmer JL, Mueller WM, Sabsevitz DS, Reitsma DC, Pillai JJ) Semin Ultrasound CT MR 2015 Jun;36(3):234-48 PMID: 26233858 PMCID: PMC4551406 08/04/2015       2 Citations
  • Preoperative diffusion tensor imaging: improving neurosurgical outcomes in brain tumor patients. (Ulmer JL, Klein AP, Mueller WM, DeYoe EA, Mark LP) Neuroimaging Clin N Am 2014 Nov;24(4):599-617 PMID: 25441503 12/03/2014       9 Citations
  • Precise ex vivo histological validation of heightened cellularity and diffusion-restricted necrosis in regions of dark apparent diffusion coefficient in 7 cases of high-grade glioma. (LaViolette PS, Mickevicius NJ, Cochran EJ, Rand SD, Connelly J, Bovi JA, Malkin MG, Mueller WM, Schmainda KM) Neuro Oncol 2014 Dec;16(12):1599-606 PMID: 25059209 PMCID: PMC4232087 07/26/2014       28 Citations
  • Comprehensive characterization of glioblastoma tumor tissues for biomarker identification using mass spectrometry-based label-free quantitative proteomics. (Heroux MS, Chesnik MA, Halligan BD, Al-Gizawiy M, Connelly JM, Mueller WM, Rand SD, Cochran EJ, LaViolette PS, Malkin MG, Schmainda KM, Mirza SP) Physiol Genomics 2014 Jul 01;46(13):467-81 PMID: 24803679 PMCID: PMC4587597 05/08/2014       15 Citations
  • Fifty consecutive hemispherectomies: outcomes, evolution of technique, complications, and lessons learned. (Lew SM, Koop JI, Mueller WM, Matthews AE, Mallonee JC) Neurosurgery 2014 Feb;74(2):182-94; discussion 195 PMID: 24176954 PMCID: PMC3916907 11/02/2013       17 Citations
  • The role of pre-treatment white matter abnormalities in developing white matter changes following whole brain radiation: a volumetric study. (Sabsevitz DS, Bovi JA, Leo PD, Laviolette PS, Rand SD, Mueller WM, Schultz CJ) J Neurooncol 2013 Sep;114(3):291-7 PMID: 23813291 07/03/2013       2 Citations
  • Effects of perfusion on diffusion changes in human brain tumors. (Cohen AD, LaViolette PS, Prah M, Connelly J, Malkin MG, Rand SD, Mueller WM, Schmainda KM) J Magn Reson Imaging 2013 Oct;38(4):868-75 PMID: 23389889 PMCID: PMC3735792 02/08/2013       3 Citations
  • Vascular change measured with independent component analysis of dynamic susceptibility contrast MRI predicts bevacizumab response in high-grade glioma. (LaViolette PS, Cohen AD, Prah MA, Rand SD, Connelly J, Malkin MG, Mueller WM, Schmainda KM) Neuro Oncol 2013 Apr;15(4):442-50 PMID: 23382287 PMCID: PMC3607265 02/06/2013       32 Citations
  • Spatially quantifying microscopic tumor invasion and proliferation using a voxel-wise solution to a glioma growth model and serial diffusion MRI. (Ellingson BM, LaViolette PS, Rand SD, Malkin MG, Connelly JM, Mueller WM, Prost RW, Schmainda KM) Magn Reson Med 2011 Apr;65(4):1131-43 PMID: 21413079 PMCID: PMC3065939 03/18/2011       34 Citations
  • Corpus callosotomy in multistage epilepsy surgery in the pediatric population. (Lin JS, Lew SM, Marcuccilli CJ, Mueller WM, Matthews AE, Koop JI, Zupanc ML) J Neurosurg Pediatr 2011 Feb;7(2):189-200 PMID: 21284466 02/03/2011       14 Citations
  • Volumetric analysis of functional diffusion maps is a predictive imaging biomarker for cytotoxic and anti-angiogenic treatments in malignant gliomas. (Ellingson BM, Malkin MG, Rand SD, LaViolette PS, Connelly JM, Mueller WM, Schmainda KM) J Neurooncol 2011 Mar;102(1):95-103 PMID: 20798977 PMCID: PMC3033973 08/28/2010       47 Citations
  • Epilepsy surgery outcomes: quality of life and seizure control. (Zupanc ML, Rubio EJ, Werner RR, Schwabe MJ, Mueller WM, Lew SM, Marcuccilli CJ, O'Connor SE, Chico MS, Eggener KA, Hecox KE) Pediatr Neurol 2010 Jan;42(1):12-20 PMID: 20004857 12/17/2009       40 Citations
  • A comparison of two fMRI methods for predicting verbal memory decline after left temporal lobectomy: language lateralization versus hippocampal activation asymmetry. (Binder JR, Swanson SJ, Sabsevitz DS, Hammeke TA, Raghavan M, Mueller WM) Epilepsia 2010 Apr;51(4):618-26 PMID: 19817807 PMCID: PMC2945221 10/13/2009       63 Citations
  • The superior longitudinal fasciculus and speech arrest. (Davtian M, Ulmer JL, Mueller WM, Gaggl W, Mulane MP, Krouwer HG) J Comput Assist Tomogr 2008 May-Jun;32(3):410-4 PMID: 18520547 06/04/2008       8 Citations
  • Use of preoperative functional MRI to predict verbal memory decline after temporal lobe epilepsy surgery. (Binder JR, Sabsevitz DS, Swanson SJ, Hammeke TA, Raghavan M, Mueller WM) Epilepsia 2008 Aug;49(8):1377-94 PMID: 18435753 PMCID: PMC2943848 04/26/2008       127 Citations
  • Predictors of naming decline after dominant temporal lobectomy: age at onset of epilepsy and age of word acquisition. (Ruff IM, Swanson SJ, Hammeke TA, Sabsevitz D, Mueller WM, Morris GL) Epilepsy Behav 2007 Mar;10(2):272-7 PMID: 17270499 02/03/2007       13 Citations
  • Presurgical and intraoperative mapping of the motor system in congenital truncation of the precentral gyrus. (Salvan CV, Ulmer JL, Mueller WM, Krouwer HG, Prost RW, Stroe GO) AJNR Am J Neuroradiol 2006 Mar;27(3):493-7 PMID: 16551983 03/23/2006       7 Citations
  • The role of diffusion tensor imaging in establishing the proximity of tumor borders to functional brain systems: implications for preoperative risk assessments and postoperative outcomes. (Ulmer JL, Salvan CV, Mueller WM, Krouwer HG, Stroe GO, Aralasmak A, Prost RW) Technol Cancer Res Treat 2004 Dec;3(6):567-76 PMID: 15560714 11/25/2004       64 Citations
  • Vagus nerve stimulation therapy: 5-year or greater outcome at a university-based epilepsy center. (Spanaki MV, Allen LS, Mueller WM, Morris GL 3rd) Seizure 2004 Dec;13(8):587-90 PMID: 15519919 11/03/2004       50 Citations
  • Lesion-induced pseudo-dominance at functional magnetic resonance imaging: implications for preoperative assessments. (Ulmer JL, Hacein-Bey L, Mathews VP, Mueller WM, DeYoe EA, Prost RW, Meyer GA, Krouwer HG, Schmainda KM) Neurosurgery 2004 Sep;55(3):569-79; discussion 580-1 PMID: 15335424 09/01/2004       132 Citations
  • Lateralising value of ictal features in partial seizures: effect on postsurgical outcome. (Alsaadi TM, Morris GL, Mueller WM) Seizure 2003 Jul;12(5):257-60 PMID: 12810337 06/18/2003       2 Citations
  • Use of preoperative functional neuroimaging to predict language deficits from epilepsy surgery. (Sabsevitz DS, Swanson SJ, Hammeke TA, Spanaki MV, Possing ET, Morris GL 3rd, Mueller WM, Binder JR) Neurology 2003 Jun 10;60(11):1788-92 PMID: 12796532 06/11/2003       197 Citations
  • Pseudo-reorganization of language cortical function at fMR imaging: a consequence of tumor-induced neurovascular uncoupling. (Ulmer JL, Krouwer HG, Mueller WM, Ugurel MS, Kocak M, Mark LP) AJNR Am J Neuroradiol 2003 Feb;24(2):213-7 PMID: 12591636 02/20/2003       94 Citations
  • fMRI in patients implanted with a vagal nerve stimulator. (Sucholeiki R, Alsaadi TM, Morris GL 3rd, Ulmer JL, Biswal B, Mueller WM) Seizure 2002 Apr;11(3):157-62 PMID: 12018958 05/23/2002       47 Citations
  • Memory outcome after left anterior temporal lobectomy in patients with expected and reversed Wada memory asymmetry scores. (Sabsevitz DS, Swanson SJ, Morris GL, Mueller WM, Seidenberg M) Epilepsia 2001 Nov;42(11):1408-15 PMID: 11879343 03/07/2002       69 Citations
  • Magnetic resonance analysis of postsurgical temporal lobectomy. (Alsaadi TM, Ulmer JL, Mitchell MJ, Morris GL, Swanson SJ, Mueller WM) J Neuroimaging 2001 Jul;11(3):243-7 PMID: 11462289 07/21/2001    
  • Prognostic value of the consistency of lateralizing ictal features and ictal EEG in patients undergoing temporal lobectomy for refractory complex partial seizures. (Alsaadi T, Morris GL, Mueller WM) Clin Electroencephalogr 2001 Apr;32(2):87-91 PMID: 11360726 05/22/2001       2 Citations
  • Long-term treatment with vagus nerve stimulation in patients with refractory epilepsy. The Vagus Nerve Stimulation Study Group E01-E05. (Morris GL 3rd, Mueller WM) Neurology 1999 Nov 10;53(8):1731-5 PMID: 10563620 11/24/1999       449 Citations
  • Language dominance in neurologically normal and epilepsy subjects: a functional MRI study. (Springer JA, Binder JR, Hammeke TA, Swanson SJ, Frost JA, Bellgowan PS, Brewer CC, Perry HM, Morris GL, Mueller WM) Brain 1999 Nov;122 ( Pt 11):2033-46 PMID: 10545389 11/05/1999       532 Citations
  • Side of seizure focus predicts left medial temporal lobe activation during verbal encoding. (Bellgowan PS, Binder JR, Swanson SJ, Hammeke TA, Springer JA, Frost JA, Mueller WM, Morris GL) Neurology 1998 Aug;51(2):479-84 PMID: 9710022 08/26/1998       93 Citations
  • Functional MR activation correlated with intraoperative cortical mapping. (Yetkin FZ, Mueller WM, Morris GL, McAuliffe TL, Ulmer JL, Cox RW, Daniels DL, Haughton VM) AJNR Am J Neuroradiol 1997 Aug;18(7):1311-5 PMID: 9282861 08/01/1997       201 Citations
  • Functional magnetic resonance imaging of the somatosensory cortex. (Mueller WM, Yetkin FZ, Haughton VM) Neurosurg Clin N Am 1997 Jul;8(3):373-81 PMID: 9188544 07/01/1997       12 Citations
  • Functional magnetic resonance imaging mapping of the motor cortex in patients with cerebral tumors. (Mueller WM, Yetkin FZ, Hammeke TA, Morris GL 3rd, Swanson SJ, Reichert K, Cox R, Haughton VM) Neurosurgery 1996 Sep;39(3):515-20; discussion 520-1 PMID: 8875481 09/01/1996       206 Citations
  • Determination of language dominance using functional MRI: a comparison with the Wada test. (Binder JR, Swanson SJ, Hammeke TA, Morris GL, Mueller WM, Fischer M, Benbadis S, Frost JA, Rao SM, Haughton VM) Neurology 1996 Apr;46(4):978-84 PMID: 8780076 04/01/1996       695 Citations
  • Location of the sensorimotor cortex: functional and conventional MR compared. (Yetkin FZ, Papke RA, Mark LP, Daniels DL, Mueller WM, Haughton VM) AJNR Am J Neuroradiol 1995 Nov-Dec;16(10):2109-13 PMID: 8585502 11/01/1995       49 Citations
  • Surgical management of lumbar neuropathic spinal arthropathy (Charcot joint) after traumatic thoracic paraplegia: report of two cases. (Arnold PM, Baek PN, Stillerman CB, Rice SG, Mueller WM) J Spinal Disord 1995 Oct;8(5):357-62 PMID: 8563155 10/01/1995       18 Citations
  • A comparison of functional MR activation patterns during silent and audible language tasks. (Yetkin FZ, Hammeke TA, Swanson SJ, Morris GL, Mueller WM, McAuliffe TL, Haughton VM) AJNR Am J Neuroradiol 1995 May;16(5):1087-92 PMID: 7639132 05/01/1995       134 Citations
  • Functional magnetic resonance imaging mapping of the sensorimotor cortex with tactile stimulation. (Yetkin FZ, Mueller WM, Hammeke TA, Morris GL 3rd, Haughton VM) Neurosurgery 1995 May;36(5):921-5 PMID: 7791982 05/01/1995       65 Citations
  • Functional magnetic resonance imaging in partial epilepsy. (Morris GL 3rd, Mueller WM, Yetkin FZ, Haughton VM, Hammeke TA, Swanson S, Rao SM, Jesmanowicz A, Estkowski LD, Bandettini PA) Epilepsia 1994 Nov-Dec;35(6):1194-8 PMID: 7988510 11/01/1994       49 Citations
  • Functional magnetic resonance imaging of somatosensory stimulation. (Hammeke TA, Yetkin FZ, Mueller WM, Morris GL, Haughton VM, Rao SM, Binder JR) Neurosurgery 1994 Oct;35(4):677-81 PMID: 7808611 10/01/1994       109 Citations
  • Functional magnetic resonance imaging of complex human movements. (Rao SM, Binder JR, Bandettini PA, Hammeke TA, Yetkin FZ, Jesmanowicz A, Lisk LM, Morris GL, Mueller WM, Estkowski LD) Neurology 1993 Nov;43(11):2311-8 PMID: 8232948 11/01/1993       687 Citations
  • Intrathecal baclofen for severe spasticity secondary to spinal cord injury. (Lewis KS, Mueller WM) Ann Pharmacother 1993 Jun;27(6):767-74 PMID: 8329801 06/01/1993       41 Citations
  • Intraoperative and extraoperative identification of eloquent brain using stimulation mapping. (Mueller WM, Morris GL 3rd) Neurosurg Clin N Am 1993 Apr;4(2):217-22 PMID: 8467208 04/01/1993       8 Citations
  • Use of propofol (Diprivan) for awake craniotomies: technical note. (Silbergeld DL, Mueller WM, Colley PS, Ojemann GA, Lettich E) Surg Neurol 1992 Oct;38(4):271-2 PMID: 1440214 10/01/1992       70 Citations
  • Dysphagia associated with cervical spine disorders: pathologic relationship? (Weinshel SS, Maiman DJ, Mueller WM) J Spinal Disord 1988;1(4):312-6 PMID: 2980259 01/01/1988       11 Citations
  • Last update: 08/06/2018
    jenkins-FCD Prod-300 626508253d14e4184314fb9f66322a03a5906796