Medical College of Wisconsin
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Ramani Ramchandran PhD

Ramani Ramchandran PhD

Professor

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Neonatology

Member of the Cancer Center


Publications

  • RhoC maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells. (Hoeppner LH, Sinha S, Wang Y, Bhattacharya R, Dutta S, Gong X, Bedell VM, Suresh S, Chun CZ, Ramchandran R, Ekker SC, Mukhopadhyay D) J Cell Sci 2015 Jul 1: PMID: 26136364
  • SIGIRR Genetic Variants in Premature Infants With Necrotizing Enterocolitis. (Sampath V, Menden H, Helbling D, Li K, Gastonguay A, Ramchandran R, Dimmock DP) Pediatrics 2015 Jun;135(6):e1530-4 PMID: 25963006 PMCID: PMC4444800
  • Delta-like 4 mRNA is regulated by adjacent natural antisense transcripts. (Li K, Chowdhury T, Vakeel P, Koceja C, Sampath V, Ramchandran R) Vasc Cell 2015;7:3 PMID: 25914805 PMCID: PMC4409748
  • Organization for rare diseases India (ORDI) - addressing the challenges and opportunities for the Indian rare diseases' community. (Rajasimha HK, Shirol PB, Ramamoorthy P, Hegde M, Barde S, Chandru V, Ravinandan ME, Ramchandran R, Haldar K, Lin JC, Babar IA, Girisha KM, Srinivasan S, Navaneetham D, Battu R, Devarakonda R, Kini U, Vijayachandra K, Verma IC) Genet Res (Camb) 2014;96:e009 PMID: 25579084
  • Lipopolysaccharide (LPS)-mediated angiopoietin-2-dependent autocrine angiogenesis is regulated by NADPH oxidase 2 (Nox2) in human pulmonary microvascular endothelial cells. (Menden H, Welak S, Cossette S, Ramchandran R, Sampath V) J Biol Chem 2015 Feb 27;290(9):5449-61 PMID: 25568324 PMCID: PMC4342461
  • Protein expression, characterization and activity comparisons of wild type and mutant DUSP5 proteins. (Nayak J, Gastonguay AJ, Talipov MR, Vakeel P, Span EA, Kalous KS, Kutty RG, Jensen DR, Pokkuluri PR, Sem DS, Rathore R, Ramchandran R) BMC Biochem 2014;15:27 PMID: 25519881 PMCID: PMC4299175
  • Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism. (Cossette SM, Gastonguay AJ, Bao X, Lerch-Gaggl A, Zhong L, Harmann LM, Koceja C, Miao RQ, Vakeel P, Chun C, Li K, Foeckler J, Bordas M, Weiler H, Strande J, Palecek SP, Ramchandran R) Biol Open 2014;4(1):48-61 PMID: 25505152 PMCID: PMC4295165
  • Transcriptional inhibition of etv2 expression is essential for embryonic cardiac development. (Schupp MO, Waas M, Chun CZ, Ramchandran R) Dev Biol 2014 Sep 1;393(1):71-83 PMID: 24984259 PMCID: PMC4137469
  • Astrocytes directly influence tumor cell invasion and metastasis in vivo. (Wang L, Cossette SM, Rarick KR, Gershan J, Dwinell MB, Harder DR, Ramchandran R) PLoS One 2013;8(12):e80933 PMID: 24324647 PMCID: PMC3851470
  • SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1. (Zhou X, Fan LX, Li K, Ramchandran R, Calvet JP, Li X) Hum Mol Genet 2014 Mar 15;23(6):1644-55 PMID: 24203696 PMCID: PMC3929098
  • Mmp17b is essential for proper neural crest cell migration in vivo. (Leigh NR, Schupp MO, Li K, Padmanabhan V, Gastonguay A, Wang L, Chun CZ, Wilkinson GA, Ramchandran R) PLoS One 2013;8(10):e76484 PMID: 24098510 PMCID: PMC3788140
  • Protein structure in context: the molecular landscape of angiogenesis. (Span EA, Goodsell DS, Ramchandran R, Franzen MA, Herman T, Sem DS) Biochem Mol Biol Educ 2013 Jul-Aug;41(4):213-23 PMID: 23868376 PMCID: PMC4074543
  • Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR. (Kilari S, Remadevi I, Zhao B, Pan J, Miao R, Ramchandran R, North PE, You M, Rahimi N, Wilkinson GA) J Biol Chem 2013 Apr 12;288(15):10265-74 PMID: 23393131 PMCID: PMC3624410
  • Role of dual-specificity protein phosphatase-5 in modulating the myogenic response in rat cerebral arteries. (Wickramasekera NT, Gebremedhin D, Carver KA, Vakeel P, Ramchandran R, Schuett A, Harder DR) J Appl Physiol (1985) 2013 Jan 15;114(2):252-61 PMID: 23172031 PMCID: PMC3544499
  • Studies on Axenfeld-Rieger syndrome patients and mice reveal Foxc1's role in corneal neovascularization. (François M, Ramchandran R) Proc Natl Acad Sci U S A 2012 Feb 7;109(6):1818-9 PMID: 22308435 PMCID: PMC3277551
  • Reactive oxygen species driven angiogenesis by inorganic nanorods. (Patra CR, Kim JH, Pramanik K, d'Uscio LV, Patra S, Pal K, Ramchandran R, Strano MS, Mukhopadhyay D) Nano Lett 2011 Nov 9;11(11):4932-8 PMID: 21967244 PMCID: PMC3212653
  • Sox factors transcriptionally regulate ROBO4 gene expression in developing vasculature in zebrafish. (Samant GV, Schupp MO, François M, Moleri S, Kothinti RK, Chun CZ, Sinha I, Sellars S, Leigh N, Pramanik K, Horswill MA, Remadevi I, Li K, Wilkinson GA, Tabatabai NM, Beltrame M, Koopman P, Ramchandran R) J Biol Chem 2011 Sep 2;286(35):30740-7 PMID: 21730073 PMCID: PMC3162435
  • Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ₃. (Lakshmikanthan S, Sobczak M, Chun C, Henschel A, Dargatz J, Ramchandran R, Chrzanowska-Wodnicka M) Blood 2011 Aug 18;118(7):2015-26 PMID: 21636859 PMCID: PMC3158727
  • Fli+ etsrp+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish. (Chun CZ, Remadevi I, Schupp MO, Samant GV, Pramanik K, Wilkinson GA, Ramchandran R) PLoS One 2011;6(2):e14732 PMID: 21364913 PMCID: PMC3045372
  • Natural antisense transcript: a concomitant engagement with protein-coding transcript. (Li K, Ramchandran R) Oncotarget 2010 Oct;1(6):447-52 PMID: 21311100 PMCID: PMC3248111
  • Nogo-B receptor is essential for angiogenesis in zebrafish via Akt pathway. (Zhao B, Chun C, Liu Z, Horswill MA, Pramanik K, Wilkinson GA, Ramchandran R, Miao RQ) Blood 2010 Dec 9;116(24):5423-33 PMID: 20813898 PMCID: PMC3012551
  • Endothelial cell-specific chemotaxis receptor (ecscr) promotes angioblast migration during vasculogenesis and enhances VEGF receptor sensitivity. (Verma A, Bhattacharya R, Remadevi I, Li K, Pramanik K, Samant GV, Horswill M, Chun CZ, Zhao B, Wang E, Miao RQ, Mukhopadhyay D, Ramchandran R, Wilkinson GA) Blood 2010 Jun 3;115(22):4614-22 PMID: 20086248 PMCID: PMC2881497
  • A noncoding antisense RNA in tie-1 locus regulates tie-1 function in vivo. (Li K, Blum Y, Verma A, Liu Z, Pramanik K, Leigh NR, Chun CZ, Samant GV, Zhao B, Garnaas MK, Horswill MA, Stanhope SA, North PE, Miao RQ, Wilkinson GA, Affolter M, Ramchandran R) Blood 2010 Jan 7;115(1):133-9 PMID: 19880500 PMCID: PMC2803688
  • Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton. (Jia Y, Wu SL, Isenberg JS, Dai S, Sipes JM, Field L, Zeng B, Bandle RW, Ridnour LA, Wink DA, Ramchandran R, Karger BL, Roberts DD) Cell Stress Chaperones 2010 Mar;15(2):165-81 PMID: 19579057 PMCID: PMC2866983
  • Specific inhibition of cyclin-dependent kinase 5 activity induces motor neuron development in vivo. (Kanungo J, Zheng YL, Amin ND, Kaur S, Ramchandran R, Pant HC) Biochem Biophys Res Commun 2009 Aug 14;386(1):263-7 PMID: 19523926 PMCID: PMC2758157
  • A whole-animal microplate assay for metabolic rate using zebrafish. (Makky K, Duvnjak P, Pramanik K, Ramchandran R, Mayer AN) J Biomol Screen 2008 Dec;13(10):960-7 PMID: 19029015
  • Silencing of directional migration in roundabout4 knockdown endothelial cells. (Kaur S, Samant GV, Pramanik K, Loscombe PW, Pendrak ML, Roberts DD, Ramchandran R) BMC Cell Biol 2008;9:61 PMID: 18980679 PMCID: PMC2613885
  • Dusp-5 and Snrk-1 coordinately function during vascular development and disease. (Pramanik K, Chun CZ, Garnaas MK, Samant GV, Li K, Horswill MA, North PE, Ramchandran R) Blood 2009 Jan 29;113(5):1184-91 PMID: 18927432 PMCID: PMC2635084
  • Syx, a RhoA guanine exchange factor, is essential for angiogenesis in Vivo. (Garnaas MK, Moodie KL, Liu ML, Samant GV, Li K, Marx R, Baraban JM, Horowitz A, Ramchandran R) Circ Res 2008 Sep 26;103(7):710-6 PMID: 18757825 PMCID: PMC2758496
  • Snrk-1 is involved in multiple steps of angioblast development and acts via notch signaling pathway in artery-vein specification in vertebrates. (Chun CZ, Kaur S, Samant GV, Wang L, Pramanik K, Garnaas MK, Li K, Field L, Mukhopadhyay D, Ramchandran R) Blood 2009 Jan 29;113(5):1192-9 PMID: 18723694 PMCID: PMC2635085
  • Expression pattern for unc5b, an axon guidance gene in embryonic zebrafish development. (Kaur S, Abu-Asab MS, Singla S, Yeo SY, Ramchandran R) Gene Expr 2007;13(6):321-7 PMID: 17708418 PMCID: PMC2562791
  • Modulation of angiogenesis by dithiolethione-modified NSAIDs and valproic acid. (Isenberg JS, Jia Y, Field L, Ridnour LA, Sparatore A, Del Soldato P, Sowers AL, Yeh GC, Moody TW, Wink DA, Ramchandran R, Roberts DD) Br J Pharmacol 2007 May;151(1):63-72 PMID: 17351657 PMCID: PMC2012973
  • Cloning and characterization of zebrafish (Danio rerio) cyclin-dependent kinase 5. (Kanungo J, Li BS, Goswami M, Zheng YL, Ramchandran R, Pant HC) Neurosci Lett 2007 Feb 2;412(3):233-8 PMID: 17178437 PMCID: PMC2696171
  • Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis. (Arbiser JL, Kau T, Konar M, Narra K, Ramchandran R, Summers SA, Vlahos CJ, Ye K, Perry BN, Matter W, Fischl A, Cook J, Silver PA, Bain J, Cohen P, Whitmire D, Furness S, Govindarajan B, Bowen JP) Blood 2007 Jan 15;109(2):560-5 PMID: 16990598 PMCID: PMC1785094
  • A novel endothelial-specific heat shock protein HspA12B is required in both zebrafish development and endothelial functions in vitro. (Hu G, Tang J, Zhang B, Lin Y, Hanai J, Galloway J, Bedell V, Bahary N, Han Z, Ramchandran R, Thisse B, Thisse C, Zon LI, Sukhatme VP) J Cell Sci 2006 Oct 1;119(Pt 19):4117-26 PMID: 16968741
  • Robo4 signaling in endothelial cells implies attraction guidance mechanisms. (Kaur S, Castellone MD, Bedell VM, Konar M, Gutkind JS, Ramchandran R) J Biol Chem 2006 Apr 21;281(16):11347-56 PMID: 16481322
  • roundabout4 is essential for angiogenesis in vivo. (Bedell VM, Yeo SY, Park KW, Chung J, Seth P, Shivalingappa V, Zhao J, Obara T, Sukhatme VP, Drummond IA, Li DY, Ramchandran R) Proc Natl Acad Sci U S A 2005 May 3;102(18):6373-8 PMID: 15849270 PMCID: PMC1088354
  • Critical roles of CD146 in zebrafish vascular development. (Chan B, Sinha S, Cho D, Ramchandran R, Sukhatme VP) Dev Dyn 2005 Jan;232(1):232-44 PMID: 15580611
  • Cellular actions and signaling by endostatin. (Ramchandran R, Karumanchi SA, Hanai J, Alper SL, Sukhatme VP) Crit Rev Eukaryot Gene Expr 2002;12(3):175-91 PMID: 12449342 PMCID: PMC3270378
  • Endostatin is a potential inhibitor of Wnt signaling. (Hanai J, Gloy J, Karumanchi SA, Kale S, Tang J, Hu G, Chan B, Ramchandran R, Jha V, Sukhatme VP, Sokol S) J Cell Biol 2002 Aug 5;158(3):529-39 PMID: 12147676 PMCID: PMC2173844
  • Endostatin causes G1 arrest of endothelial cells through inhibition of cyclin D1. (Hanai J, Dhanabal M, Karumanchi SA, Albanese C, Waterman M, Chan B, Ramchandran R, Pestell R, Sukhatme VP) J Biol Chem 2002 May 10;277(19):16464-9 PMID: 11815623
  • Cell surface glypicans are low-affinity endostatin receptors. (Karumanchi SA, Jha V, Ramchandran R, Karihaloo A, Tsiokas L, Chan B, Dhanabal M, Hanai JI, Venkataraman G, Shriver Z, Keiser N, Kalluri R, Zeng H, Mukhopadhyay D, Chen RL, Lander AD, Hagihara K, Yamaguchi Y, Sasisekharan R, Cantley L, Sukhatme VP) Mol Cell 2001 Apr;7(4):811-22 PMID: 11336704
  • Antitumor interaction of short-course endostatin and ionizing radiation. (Hanna NN, Seetharam S, Mauceri HJ, Beckett MA, Jaskowiak NT, Salloum RM, Hari D, Dhanabal M, Ramchandran R, Kalluri R, Sukhatme VP, Kufe DW, Weichselbaum RR) Cancer J 2000 Sep-Oct;6(5):287-93 PMID: 11079167
  • A (GATA)(7) motif located in the 5' boundary area of the human beta-globin locus control region exhibits silencer activity in erythroid cells. (Ramchandran R, Bengra C, Whitney B, Lanclos K, Tuan D) Am J Hematol 2000 Sep;65(1):14-24 PMID: 10936858
  • Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth. (Kamphaus GD, Colorado PC, Panka DJ, Hopfer H, Ramchandran R, Torre A, Maeshima Y, Mier JW, Sukhatme VP, Kalluri R) J Biol Chem 2000 Jan 14;275(2):1209-15 PMID: 10625665
  • Cloning, expression, and in vitro activity of human endostatin. (Dhanabal M, Volk R, Ramchandran R, Simons M, Sukhatme VP) Biochem Biophys Res Commun 1999 May 10;258(2):345-52 PMID: 10329390
  • Kringle 5 causes cell cycle arrest and apoptosis of endothelial cells. (Lu H, Dhanabal M, Volk R, Waterman MJ, Ramchandran R, Knebelmann B, Segal M, Sukhatme VP) Biochem Biophys Res Commun 1999 May 19;258(3):668-73 PMID: 10329443
  • Endostatin induces endothelial cell apoptosis. (Dhanabal M, Ramchandran R, Waterman MJ, Lu H, Knebelmann B, Segal M, Sukhatme VP) J Biol Chem 1999 Apr 23;274(17):11721-6 PMID: 10206987
  • Antiangiogenic activity of restin, NC10 domain of human collagen XV: comparison to endostatin. (Ramchandran R, Dhanabal M, Volk R, Waterman MJ, Segal M, Lu H, Knebelmann B, Sukhatme VP) Biochem Biophys Res Commun 1999 Feb 24;255(3):735-9 PMID: 10049780
  • Endostatin: yeast production, mutants, and antitumor effect in renal cell carcinoma. (Dhanabal M, Ramchandran R, Volk R, Stillman IE, Lombardo M, Iruela-Arispe ML, Simons M, Sukhatme VP) Cancer Res 1999 Jan 1;59(1):189-97 PMID: 9892206
  • Last update: 07/27/2015