Medical College of Wisconsin
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Brian A. Link PhD

Brian A. Link PhD

Professor

Institution: Medical College of Wisconsin
Department: Cell Biology, Neurobiology and Anatomy
Program: Administration

Member of the Cancer Center
Member of the Neuroscience Research Center


Publications

  • Establishment of transgenic lines to monitor and manipulate Yap/Taz-Tead activity in zebrafish reveals both evolutionarily conserved and divergent functions of the Hippo pathway. (Miesfeld JB, Link BA) Mech Dev 2014 Aug;133:177-88 PMID: 24560909 PMCID: PMC4138299 02/25/2014
  • Mirror-symmetric microtubule assembly and cell interactions drive lumen formation in the zebrafish neural rod. (Buckley CE, Ren X, Ward LC, Girdler GC, Araya C, Green MJ, Clark BS, Link BA, Clarke JD) EMBO J 2013 Jan 9;32(1):30-44 PMID: 23202854 PMCID: PMC3545300 12/04/2012
  • Integrin α5/fibronectin1 and focal adhesion kinase are required for lens fiber morphogenesis in zebrafish. (Hayes JM, Hartsock A, Clark BS, Napier HR, Link BA, Gross JM) Mol Biol Cell 2012 Dec;23(24):4725-38 PMID: 23097490 PMCID: PMC3521681 10/26/2012
  • Loss of Llgl1 in retinal neuroepithelia reveals links between apical domain size, Notch activity and neurogenesis. (Clark BS, Cui S, Miesfeld JB, Klezovitch O, Vasioukhin V, Link BA) Development 2012 May;139(9):1599-610 PMID: 22492354 PMCID: PMC3317966 04/12/2012
  • Generation of Rab-based transgenic lines for in vivo studies of endosome biology in zebrafish. (Clark BS, Winter M, Cohen AR, Link BA) Dev Dyn 2011 Nov;240(11):2452-65 PMID: 21976318 PMCID: PMC3197968 10/07/2011
  • The ciliopathy gene cc2d2a controls zebrafish photoreceptor outer segment development through a role in Rab8-dependent vesicle trafficking. (Bachmann-Gagescu R, Phelps IG, Stearns G, Link BA, Brockerhoff SE, Moens CB, Doherty D) Hum Mol Genet 2011 Oct 15;20(20):4041-55 PMID: 21816947 PMCID: PMC3177654 08/06/2011
  • Cell biological regulation of division fate in vertebrate neuroepithelial cells. (Willardsen MI, Link BA) Dev Dyn 2011 Aug;240(8):1865-79 PMID: 21761474 PMCID: PMC3140019 07/16/2011
  • The visual system of zebrafish and its use to model human ocular diseases. (Gestri G, Link BA, Neuhauss SC) Dev Neurobiol 2012 Mar;72(3):302-27 PMID: 21595048 PMCID: PMC3202066 05/20/2011
  • Loss of Lrp2 in zebrafish disrupts pronephric tubular clearance but not forebrain development. (Kur E, Christa A, Veth KN, Gajera CR, Andrade-Navarro MA, Zhang J, Willer JR, Gregg RG, Abdelilah-Seyfried S, Bachmann S, Link BA, Hammes A, Willnow TE) Dev Dyn 2011 Jun;240(6):1567-77 PMID: 21455927 PMCID: PMC3278082 04/02/2011
  • Mutations in zebrafish lrp2 result in adult-onset ocular pathogenesis that models myopia and other risk factors for glaucoma. (Veth KN, Willer JR, Collery RF, Gray MP, Willer GB, Wagner DS, Mullins MC, Udvadia AJ, Smith RS, John SW, Gregg RG, Link BA) PLoS Genet 2011 Feb;7(2):e1001310 PMID: 21379331 PMCID: PMC3040661 03/08/2011
  • Dynamic smad-mediated BMP signaling revealed through transgenic zebrafish. (Collery RF, Link BA) Dev Dyn 2011 Mar;240(3):712-22 PMID: 21337469 PMCID: PMC3072245 02/22/2011
  • In vivo development of dendritic orientation in wild-type and mislocalized retinal ganglion cells. (Choi JH, Law MY, Chien CB, Link BA, Wong RO) Neural Dev 2010;5:29 PMID: 21044295 PMCID: PMC2988773 11/04/2010
  • Potential novel mechanism for Axenfeld-Rieger syndrome: deletion of a distant region containing regulatory elements of PITX2. (Volkmann BA, Zinkevich NS, Mustonen A, Schilter KF, Bosenko DV, Reis LM, Broeckel U, Link BA, Semina EV) Invest Ophthalmol Vis Sci 2011 Mar;52(3):1450-9 PMID: 20881290 PMCID: PMC3101680 10/01/2010
  • Analysis of a zebrafish dync1h1 mutant reveals multiple functions for cytoplasmic dynein 1 during retinal photoreceptor development. (Insinna C, Baye LM, Amsterdam A, Besharse JC, Link BA) Neural Dev 2010;5:12 PMID: 20412557 PMCID: PMC2880287 04/24/2010
  • Actomyosin is the main driver of interkinetic nuclear migration in the retina. (Norden C, Young S, Link BA, Harris WA) Cell 2009 Sep 18;138(6):1195-208 PMID: 19766571 PMCID: PMC2791877 09/22/2009
  • Lmx1b is essential for survival of periocular mesenchymal cells and influences Fgf-mediated retinal patterning in zebrafish. (McMahon C, Gestri G, Wilson SW, Link BA) Dev Biol 2009 Aug 15;332(2):287-98 PMID: 19500562 PMCID: PMC2716413 06/09/2009
  • FoxC1 is essential for vascular basement membrane integrity and hyaloid vessel morphogenesis. (Skarie JM, Link BA) Invest Ophthalmol Vis Sci 2009 Nov;50(11):5026-34 PMID: 19458328 PMCID: PMC3651675 05/22/2009
  • Apical membrane maturation and cellular rosette formation during morphogenesis of the zebrafish lateral line. (Hava D, Forster U, Matsuda M, Cui S, Link BA, Eichhorst J, Wiesner B, Chitnis A, Abdelilah-Seyfried S) J Cell Sci 2009 Mar 1;122(Pt 5):687-95 PMID: 19208766 PMCID: PMC3188803 02/12/2009
  • Analysis of IFT kinesins in developing zebrafish cone photoreceptor sensory cilia. (Insinna C, Luby-Phelps K, Link BA, Besharse JC) Methods Cell Biol 2009;93:219-34 PMID: 20409820 01/01/2009
  • The aqueous humor outflow pathway of zebrafish. (Gray MP, Smith RS, Soules KA, John SW, Link BA) Invest Ophthalmol Vis Sci 2009 Apr;50(4):1515-21 PMID: 19060283 PMCID: PMC3642099 12/09/2008
  • Regulation of neurogenesis by interkinetic nuclear migration through an apical-basal notch gradient. (Del Bene F, Wehman AM, Link BA, Baier H) Cell 2008 Sep 19;134(6):1055-65 PMID: 18805097 PMCID: PMC2628487 09/23/2008
  • Factorial microarray analysis of zebrafish retinal development. (Leung YF, Ma P, Link BA, Dowling JE) Proc Natl Acad Sci U S A 2008 Sep 2;105(35):12909-14 PMID: 18753621 PMCID: PMC2529063 08/30/2008
  • The primary open-angle glaucoma gene WDR36 functions in ribosomal RNA processing and interacts with the p53 stress-response pathway. (Skarie JM, Link BA) Hum Mol Genet 2008 Aug 15;17(16):2474-85 PMID: 18469340 PMCID: PMC2722886 05/13/2008
  • FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A. (Berry FB, Skarie JM, Mirzayans F, Fortin Y, Hudson TJ, Raymond V, Link BA, Walter MA) Hum Mol Genet 2008 Feb 15;17(4):490-505 PMID: 17993506 11/13/2007
  • Interkinetic nuclear migration and the selection of neurogenic cell divisions during vertebrate retinogenesis. (Baye LM, Link BA) J Neurosci 2007 Sep 19;27(38):10143-52 PMID: 17881520 09/21/2007
  • Nuclear migration during retinal development. (Baye LM, Link BA) Brain Res 2008 Feb 4;1192:29-36 PMID: 17560964 PMCID: PMC2674389 06/15/2007
  • The disarrayed mutation results in cell cycle and neurogenesis defects during retinal development in zebrafish. (Baye LM, Link BA) BMC Dev Biol 2007;7:28 PMID: 17411431 PMCID: PMC1854893 04/07/2007
  • Analysis of aPKClambda and aPKCzeta reveals multiple and redundant functions during vertebrate retinogenesis. (Cui S, Otten C, Rohr S, Abdelilah-Seyfried S, Link BA) Mol Cell Neurosci 2007 Mar;34(3):431-44 PMID: 17223574 PMCID: PMC2700298 01/16/2007
  • FGF19 is a target for FOXC1 regulation in ciliary body-derived cells. (Tamimi Y, Skarie JM, Footz T, Berry FB, Link BA, Walter MA) Hum Mol Genet 2006 Nov 1;15(21):3229-40 PMID: 17000708 09/27/2006
  • Mutations in laminin alpha 1 result in complex, lens-independent ocular phenotypes in zebrafish. (Semina EV, Bosenko DV, Zinkevich NC, Soules KA, Hyde DR, Vihtelic TS, Willer GB, Gregg RG, Link BA) Dev Biol 2006 Nov 1;299(1):63-77 PMID: 16973147 09/16/2006
  • laminin alpha 1 gene is essential for normal lens development in zebrafish. (Zinkevich NS, Bosenko DV, Link BA, Semina EV) BMC Dev Biol 2006;6:13 PMID: 16522196 PMCID: PMC1450269 03/09/2006
  • Morphogenesis of the anterior segment in the zebrafish eye. (Soules KA, Link BA) BMC Dev Biol 2005;5:12 PMID: 15985175 PMCID: PMC1183199 06/30/2005
  • Analysis of the Zebrafish perplexed mutation reveals tissue-specific roles for de novo pyrimidine synthesis during development. (Willer GB, Lee VM, Gregg RG, Link BA) Genetics 2005 Aug;170(4):1827-37 PMID: 15937129 PMCID: PMC1449754 06/07/2005
  • Staggered cell-intrinsic timing of ath5 expression underlies the wave of ganglion cell neurogenesis in the zebrafish retina. (Kay JN, Link BA, Baier H) Development 2005 Jun;132(11):2573-85 PMID: 15857917 04/29/2005
  • dazed gene is necessary for late cell type development and retinal cell maintenance in the zebrafish retina. (Perkins BD, Nicholas CS, Baye LM, Link BA, Dowling JE) Dev Dyn 2005 Jun;233(2):680-94 PMID: 15844196 04/22/2005
  • Intraocular pressure in zebrafish: comparison of inbred strains and identification of a reduced melanin mutant with raised IOP. (Link BA, Gray MP, Smith RS, John SW) Invest Ophthalmol Vis Sci 2004 Dec;45(12):4415-22 PMID: 15557450 11/24/2004
  • Using zebrafish to study the complex genetics of glaucoma. (McMahon C, Semina EV, Link BA) Comp Biochem Physiol C Toxicol Pharmacol 2004 Jul;138(3):343-50 PMID: 15533792 11/10/2004
  • Positional cloning of the young mutation identifies an essential role for the Brahma chromatin remodeling complex in mediating retinal cell differentiation. (Gregg RG, Willer GB, Fadool JM, Dowling JE, Link BA) Proc Natl Acad Sci U S A 2003 May 27;100(11):6535-40 PMID: 12748389 PMCID: PMC164481 05/16/2003
  • Suppression of lens growth by alphaA-crystallin promoter-driven expression of diphtheria toxin results in disruption of retinal cell organization in zebrafish. (Kurita R, Sagara H, Aoki Y, Link BA, Arai K, Watanabe S) Dev Biol 2003 Mar 1;255(1):113-27 PMID: 12618137 03/06/2003
  • Evidence for directed mitotic cleavage plane reorientations during retinal development within the zebrafish. (Link BA) Biol Bull 2001 Oct;201(2):254-5 PMID: 11687408 11/01/2001
  • The perplexed and confused mutations affect distinct stages during the transition from proliferating to post-mitotic cells within the zebrafish retina. (Link BA, Kainz PM, Ryou T, Dowling JE) Dev Biol 2001 Aug 15;236(2):436-53 PMID: 11476583 07/31/2001
  • Genetic analysis of initial and ongoing retinogenesis in the zebrafish: comparing the central neuroepithelium and marginal zone. (Link BA, Darland T) Prog Brain Res 2001;131:565-77 PMID: 11420971 06/26/2001
  • Small molecule developmental screens reveal the logic and timing of vertebrate development. (Peterson RT, Link BA, Dowling JE, Schreiber SL) Proc Natl Acad Sci U S A 2000 Nov 21;97(24):12965-9 PMID: 11087852 PMCID: PMC27161 11/23/2000
  • The zebrafish young mutation acts non-cell-autonomously to uncouple differentiation from specification for all retinal cells. (Link BA, Fadool JM, Malicki J, Dowling JE) Development 2000 May;127(10):2177-88 PMID: 10769241 04/19/2000
  • Development of the avian iris and ciliary body: mechanisms of cellular differentiation during the smooth-to-striated muscle transition. (Link BA, Nishi R) Dev Biol 1998 Nov 1;203(1):163-76 PMID: 9806781 11/10/1998
  • Development of the avian iris and ciliary body: the role of activin and follistatin in coordination of the smooth-to-striated muscle transition. (Link BA, Nishi R) Dev Biol 1998 Jul 15;199(2):226-34 PMID: 9698442 08/12/1998
  • Opposing effects of activin A and follistatin on developing skeletal muscle cells. (Link BA, Nishi R) Exp Cell Res 1997 Jun 15;233(2):350-62 PMID: 9194497 06/15/1997
  • Activin A and follistatin expression in developing targets of ciliary ganglion neurons suggests a role in regulating neurotransmitter phenotype. (Darland DC, Link BA, Nishi R) Neuron 1995 Oct;15(4):857-66 PMID: 7576634 10/01/1995
  • Last update: 04/27/2014