Medical College of Wisconsin
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Brian A. Link PhD

Brian A. Link PhD


Institution: Medical College of Wisconsin
Department: Cell Biology, Neurobiology and Anatomy
Program: Administration

Member of the Cancer Center
Member of the Cardiovascular Center
Member of the Neuroscience Research Center


  • The Effect of Retinal Melanin on Optical Coherence Tomography Images. (Wilk MA, Huckenpahler AL, Collery RF, Link BA, Carroll J) Transl Vis Sci Technol 2017 Apr;6(2):8 PMID: 28392975 PMCID: PMC5381330 04/11/2017    
  • Cos2/Kif7 and Osm-3/Kif17 regulate onset of outer segment development in zebrafish photoreceptors through distinct mechanisms. (Lewis TR, Kundinger SR, Pavlovich AL, Bostrom JR, Link BA, Besharse JC) Dev Biol 2017 05 15;425(2):176-190 PMID: 28341548 PMCID: PMC5558849 03/28/2017       6 Citations
  • Producing tissue specific stem cells for regeneration: how YAP/TAZ may prove useful. (Henle SJ, Link BA) Stem Cell Investig 2017;4:16 PMID: 28275646 PMCID: PMC5334554 03/10/2017    
  • Imaging the adult zebrafish cone mosaic using optical coherence tomography. (Huckenpahler AL, Wilk MA, Cooper RF, Moehring F, Link BA, Carroll J, Collery RF) Vis Neurosci 2016 01;33:E011 PMID: 28177275 PMCID: PMC5659228 02/09/2017       2 Citations
  • Loss of Zebrafish Mfrp Causes Nanophthalmia, Hyperopia, and Accumulation of Subretinal Macrophages. (Collery RF, Volberding PJ, Bostrom JR, Link BA, Besharse JC) Invest Ophthalmol Vis Sci 2016 12 01;57(15):6805-6814 PMID: 28002843 PMCID: PMC5215506 12/22/2016       7 Citations
  • Lmx1b is required for the glutamatergic fates of a subset of spinal cord neurons. (Hilinski WC, Bostrom JR, England SJ, Juárez-Morales JL, de Jager S, Armant O, Legradi J, Strähle U, Link BA, Lewis KE) Neural Dev 2016 08 23;11(1):16 PMID: 27553035 PMCID: PMC4995821 08/25/2016       3 Citations
  • Zebrafish Models of Retinal Disease. (Link BA, Collery RF) Annu Rev Vis Sci 2015 Nov 24;1:125-153 PMID: 28532376 11/24/2015    
  • Yap and Taz regulate retinal pigment epithelial cell fate. (Miesfeld JB, Gestri G, Clark BS, Flinn MA, Poole RJ, Bader JR, Besharse JC, Wilson SW, Link BA) Development 2015 Sep 01;142(17):3021-32 PMID: 26209646 PMCID: PMC4582179 07/26/2015       28 Citations
  • YAP is essential for tissue tension to ensure vertebrate 3D body shape. (Porazinski S, Wang H, Asaoka Y, Behrndt M, Miyamoto T, Morita H, Hata S, Sasaki T, Krens SFG, Osada Y, Asaka S, Momoi A, Linton S, Miesfeld JB, Link BA, Senga T, Shimizu N, Nagase H, Matsuura S, Bagby S, Kondoh H, Nishina H, Heisenberg CP, Furutani-Seiki M) Nature 2015 May 14;521(7551):217-221 PMID: 25778702 PMCID: PMC4720436 03/18/2015       88 Citations
  • Rapid, accurate, and non-invasive measurement of zebrafish axial length and other eye dimensions using SD-OCT allows longitudinal analysis of myopia and emmetropization. (Collery RF, Veth KN, Dubis AM, Carroll J, Link BA) PLoS One 2014;9(10):e110699 PMID: 25334040 PMCID: PMC4205002 10/22/2014       12 Citations
  • Loss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamics. (Paulus JD, Link BA) PLoS One 2014;9(10):e109922 PMID: 25329564 PMCID: PMC4199637 10/21/2014       10 Citations
  • Shroom3 contributes to the maintenance of the glomerular filtration barrier integrity. (Yeo NC, O'Meara CC, Bonomo JA, Veth KN, Tomar R, Flister MJ, Drummond IA, Bowden DW, Freedman BI, Lazar J, Link BA, Jacob HJ) Genome Res 2015 Jan;25(1):57-65 PMID: 25273069 PMCID: PMC4317173 10/03/2014       20 Citations
  • Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. (Tang Y, Gholamin S, Schubert S, Willardson MI, Lee A, Bandopadhayay P, Bergthold G, Masoud S, Nguyen B, Vue N, Balansay B, Yu F, Oh S, Woo P, Chen S, Ponnuswami A, Monje M, Atwood SX, Whitson RJ, Mitra S, Cheshier SH, Qi J, Beroukhim R, Tang JY, Wechsler-Reya R, Oro AE, Link BA, Bradner JE, Cho YJ) Nat Med 2014 Jul;20(7):732-40 PMID: 24973920 PMCID: PMC4108909 06/30/2014       125 Citations
  • Establishment of transgenic lines to monitor and manipulate Yap/Taz-Tead activity in zebrafish reveals both evolutionarily conserved and divergent functions of the Hippo pathway. (Miesfeld JB, Link BA) Mech Dev 2014 Aug;133:177-88 PMID: 24560909 PMCID: PMC4138299 02/25/2014       21 Citations
  • Mirror-symmetric microtubule assembly and cell interactions drive lumen formation in the zebrafish neural rod. (Buckley CE, Ren X, Ward LC, Girdler GC, Araya C, Green MJ, Clark BS, Link BA, Clarke JD) EMBO J 2013 Jan 09;32(1):30-44 PMID: 23202854 PMCID: PMC3545300 12/04/2012       28 Citations
  • Integrin α5/fibronectin1 and focal adhesion kinase are required for lens fiber morphogenesis in zebrafish. (Hayes JM, Hartsock A, Clark BS, Napier HR, Link BA, Gross JM) Mol Biol Cell 2012 Dec;23(24):4725-38 PMID: 23097490 PMCID: PMC3521681 10/26/2012       17 Citations
  • Loss of Llgl1 in retinal neuroepithelia reveals links between apical domain size, Notch activity and neurogenesis. (Clark BS, Cui S, Miesfeld JB, Klezovitch O, Vasioukhin V, Link BA) Development 2012 May;139(9):1599-610 PMID: 22492354 PMCID: PMC3317966 04/12/2012       30 Citations
  • Generation of Rab-based transgenic lines for in vivo studies of endosome biology in zebrafish. (Clark BS, Winter M, Cohen AR, Link BA) Dev Dyn 2011 Nov;240(11):2452-65 PMID: 21976318 PMCID: PMC3197968 10/07/2011       34 Citations
  • The ciliopathy gene cc2d2a controls zebrafish photoreceptor outer segment development through a role in Rab8-dependent vesicle trafficking. (Bachmann-Gagescu R, Phelps IG, Stearns G, Link BA, Brockerhoff SE, Moens CB, Doherty D) Hum Mol Genet 2011 Oct 15;20(20):4041-55 PMID: 21816947 PMCID: PMC3177654 08/06/2011       61 Citations
  • Cell biological regulation of division fate in vertebrate neuroepithelial cells. (Willardsen MI, Link BA) Dev Dyn 2011 Aug;240(8):1865-79 PMID: 21761474 PMCID: PMC3140019 07/16/2011       20 Citations
  • The visual system of zebrafish and its use to model human ocular diseases. (Gestri G, Link BA, Neuhauss SC) Dev Neurobiol 2012 Mar;72(3):302-27 PMID: 21595048 PMCID: PMC3202066 05/20/2011       50 Citations
  • Loss of Lrp2 in zebrafish disrupts pronephric tubular clearance but not forebrain development. (Kur E, Christa A, Veth KN, Gajera CR, Andrade-Navarro MA, Zhang J, Willer JR, Gregg RG, Abdelilah-Seyfried S, Bachmann S, Link BA, Hammes A, Willnow TE) Dev Dyn 2011 Jun;240(6):1567-77 PMID: 21455927 PMCID: PMC3278082 04/02/2011       17 Citations
  • Mutations in zebrafish lrp2 result in adult-onset ocular pathogenesis that models myopia and other risk factors for glaucoma. (Veth KN, Willer JR, Collery RF, Gray MP, Willer GB, Wagner DS, Mullins MC, Udvadia AJ, Smith RS, John SW, Gregg RG, Link BA) PLoS Genet 2011 Feb;7(2):e1001310 PMID: 21379331 PMCID: PMC3040661 03/08/2011       47 Citations
  • Dynamic smad-mediated BMP signaling revealed through transgenic zebrafish. (Collery RF, Link BA) Dev Dyn 2011 Mar;240(3):712-22 PMID: 21337469 PMCID: PMC3072245 02/22/2011       37 Citations
  • In vivo development of dendritic orientation in wild-type and mislocalized retinal ganglion cells. (Choi JH, Law MY, Chien CB, Link BA, Wong RO) Neural Dev 2010 Nov 02;5:29 PMID: 21044295 PMCID: PMC2988773 11/04/2010       17 Citations
  • Potential novel mechanism for Axenfeld-Rieger syndrome: deletion of a distant region containing regulatory elements of PITX2. (Volkmann BA, Zinkevich NS, Mustonen A, Schilter KF, Bosenko DV, Reis LM, Broeckel U, Link BA, Semina EV) Invest Ophthalmol Vis Sci 2011 Mar;52(3):1450-9 PMID: 20881290 PMCID: PMC3101680 10/01/2010       28 Citations
  • Analysis of a zebrafish dync1h1 mutant reveals multiple functions for cytoplasmic dynein 1 during retinal photoreceptor development. (Insinna C, Baye LM, Amsterdam A, Besharse JC, Link BA) Neural Dev 2010 Apr 22;5:12 PMID: 20412557 PMCID: PMC2880287 04/24/2010       30 Citations
  • Actomyosin is the main driver of interkinetic nuclear migration in the retina. (Norden C, Young S, Link BA, Harris WA) Cell 2009 Sep 18;138(6):1195-208 PMID: 19766571 PMCID: PMC2791877 09/22/2009       146 Citations
  • Lmx1b is essential for survival of periocular mesenchymal cells and influences Fgf-mediated retinal patterning in zebrafish. (McMahon C, Gestri G, Wilson SW, Link BA) Dev Biol 2009 Aug 15;332(2):287-98 PMID: 19500562 PMCID: PMC2716413 06/09/2009       29 Citations
  • FoxC1 is essential for vascular basement membrane integrity and hyaloid vessel morphogenesis. (Skarie JM, Link BA) Invest Ophthalmol Vis Sci 2009 Nov;50(11):5026-34 PMID: 19458328 PMCID: PMC3651675 05/22/2009       31 Citations
  • Apical membrane maturation and cellular rosette formation during morphogenesis of the zebrafish lateral line. (Hava D, Forster U, Matsuda M, Cui S, Link BA, Eichhorst J, Wiesner B, Chitnis A, Abdelilah-Seyfried S) J Cell Sci 2009 Mar 01;122(Pt 5):687-95 PMID: 19208766 PMCID: PMC3188803 02/12/2009       36 Citations
  • Analysis of IFT kinesins in developing zebrafish cone photoreceptor sensory cilia. (Insinna C, Luby-Phelps K, Link BA, Besharse JC) Methods Cell Biol 2009;93:219-34 PMID: 20409820 01/01/2009       6 Citations
  • The aqueous humor outflow pathway of zebrafish. (Gray MP, Smith RS, Soules KA, John SW, Link BA) Invest Ophthalmol Vis Sci 2009 Apr;50(4):1515-21 PMID: 19060283 PMCID: PMC3642099 12/09/2008       17 Citations
  • Regulation of neurogenesis by interkinetic nuclear migration through an apical-basal notch gradient. (Del Bene F, Wehman AM, Link BA, Baier H) Cell 2008 Sep 19;134(6):1055-65 PMID: 18805097 PMCID: PMC2628487 09/23/2008       199 Citations
  • Factorial microarray analysis of zebrafish retinal development. (Leung YF, Ma P, Link BA, Dowling JE) Proc Natl Acad Sci U S A 2008 Sep 02;105(35):12909-14 PMID: 18753621 PMCID: PMC2529063 08/30/2008       31 Citations
  • The primary open-angle glaucoma gene WDR36 functions in ribosomal RNA processing and interacts with the p53 stress-response pathway. (Skarie JM, Link BA) Hum Mol Genet 2008 Aug 15;17(16):2474-85 PMID: 18469340 PMCID: PMC2722886 05/13/2008       67 Citations
  • FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A. (Berry FB, Skarie JM, Mirzayans F, Fortin Y, Hudson TJ, Raymond V, Link BA, Walter MA) Hum Mol Genet 2008 Feb 15;17(4):490-505 PMID: 17993506 11/13/2007       55 Citations
  • Interkinetic nuclear migration and the selection of neurogenic cell divisions during vertebrate retinogenesis. (Baye LM, Link BA) J Neurosci 2007 Sep 19;27(38):10143-52 PMID: 17881520 09/21/2007       109 Citations
  • Nuclear migration during retinal development. (Baye LM, Link BA) Brain Res 2008 Feb 04;1192:29-36 PMID: 17560964 PMCID: PMC2674389 06/15/2007       77 Citations
  • The disarrayed mutation results in cell cycle and neurogenesis defects during retinal development in zebrafish. (Baye LM, Link BA) BMC Dev Biol 2007 Apr 05;7:28 PMID: 17411431 PMCID: PMC1854893 04/07/2007       16 Citations
  • Analysis of aPKClambda and aPKCzeta reveals multiple and redundant functions during vertebrate retinogenesis. (Cui S, Otten C, Rohr S, Abdelilah-Seyfried S, Link BA) Mol Cell Neurosci 2007 Mar;34(3):431-44 PMID: 17223574 PMCID: PMC2700298 01/16/2007    
  • FGF19 is a target for FOXC1 regulation in ciliary body-derived cells. (Tamimi Y, Skarie JM, Footz T, Berry FB, Link BA, Walter MA) Hum Mol Genet 2006 Nov 01;15(21):3229-40 PMID: 17000708 09/27/2006       27 Citations
  • Mutations in laminin alpha 1 result in complex, lens-independent ocular phenotypes in zebrafish. (Semina EV, Bosenko DV, Zinkevich NC, Soules KA, Hyde DR, Vihtelic TS, Willer GB, Gregg RG, Link BA) Dev Biol 2006 Nov 01;299(1):63-77 PMID: 16973147 09/16/2006       46 Citations
  • laminin alpha 1 gene is essential for normal lens development in zebrafish. (Zinkevich NS, Bosenko DV, Link BA, Semina EV) BMC Dev Biol 2006 Mar 07;6:13 PMID: 16522196 PMCID: PMC1450269 03/09/2006       33 Citations
  • Morphogenesis of the anterior segment in the zebrafish eye. (Soules KA, Link BA) BMC Dev Biol 2005 Jun 28;5:12 PMID: 15985175 PMCID: PMC1183199 06/30/2005       90 Citations
  • Analysis of the Zebrafish perplexed mutation reveals tissue-specific roles for de novo pyrimidine synthesis during development. (Willer GB, Lee VM, Gregg RG, Link BA) Genetics 2005 Aug;170(4):1827-37 PMID: 15937129 PMCID: PMC1449754 06/07/2005       28 Citations
  • Staggered cell-intrinsic timing of ath5 expression underlies the wave of ganglion cell neurogenesis in the zebrafish retina. (Kay JN, Link BA, Baier H) Development 2005 Jun;132(11):2573-85 PMID: 15857917 04/29/2005       86 Citations
  • dazed gene is necessary for late cell type development and retinal cell maintenance in the zebrafish retina. (Perkins BD, Nicholas CS, Baye LM, Link BA, Dowling JE) Dev Dyn 2005 Jun;233(2):680-94 PMID: 15844196 04/22/2005       13 Citations
  • Intraocular pressure in zebrafish: comparison of inbred strains and identification of a reduced melanin mutant with raised IOP. (Link BA, Gray MP, Smith RS, John SW) Invest Ophthalmol Vis Sci 2004 Dec;45(12):4415-22 PMID: 15557450 11/24/2004       36 Citations
  • Using zebrafish to study the complex genetics of glaucoma. (McMahon C, Semina EV, Link BA) Comp Biochem Physiol C Toxicol Pharmacol 2004 Jul;138(3):343-50 PMID: 15533792 11/10/2004       44 Citations
  • Positional cloning of the young mutation identifies an essential role for the Brahma chromatin remodeling complex in mediating retinal cell differentiation. (Gregg RG, Willer GB, Fadool JM, Dowling JE, Link BA) Proc Natl Acad Sci U S A 2003 May 27;100(11):6535-40 PMID: 12748389 PMCID: PMC164481 05/16/2003       74 Citations
  • Suppression of lens growth by alphaA-crystallin promoter-driven expression of diphtheria toxin results in disruption of retinal cell organization in zebrafish. (Kurita R, Sagara H, Aoki Y, Link BA, Arai K, Watanabe S) Dev Biol 2003 Mar 01;255(1):113-27 PMID: 12618137 03/06/2003       77 Citations
  • Evidence for directed mitotic cleavage plane reorientations during retinal development within the zebrafish. (Link BA) Biol Bull 2001 Oct;201(2):254-5 PMID: 11687408 11/01/2001       2 Citations
  • The perplexed and confused mutations affect distinct stages during the transition from proliferating to post-mitotic cells within the zebrafish retina. (Link BA, Kainz PM, Ryou T, Dowling JE) Dev Biol 2001 Aug 15;236(2):436-53 PMID: 11476583 07/31/2001       25 Citations
  • Genetic analysis of initial and ongoing retinogenesis in the zebrafish: comparing the central neuroepithelium and marginal zone. (Link BA, Darland T) Prog Brain Res 2001;131:565-77 PMID: 11420971 06/26/2001       10 Citations
  • Small molecule developmental screens reveal the logic and timing of vertebrate development. (Peterson RT, Link BA, Dowling JE, Schreiber SL) Proc Natl Acad Sci U S A 2000 Nov 21;97(24):12965-9 PMID: 11087852 PMCID: PMC27161 11/23/2000       392 Citations
  • The zebrafish young mutation acts non-cell-autonomously to uncouple differentiation from specification for all retinal cells. (Link BA, Fadool JM, Malicki J, Dowling JE) Development 2000 May;127(10):2177-88 PMID: 10769241 04/19/2000       89 Citations
  • Development of the avian iris and ciliary body: mechanisms of cellular differentiation during the smooth-to-striated muscle transition. (Link BA, Nishi R) Dev Biol 1998 Nov 01;203(1):163-76 PMID: 9806781 11/10/1998       22 Citations
  • Development of the avian iris and ciliary body: the role of activin and follistatin in coordination of the smooth-to-striated muscle transition. (Link BA, Nishi R) Dev Biol 1998 Jul 15;199(2):226-34 PMID: 9698442 08/12/1998       16 Citations
  • Opposing effects of activin A and follistatin on developing skeletal muscle cells. (Link BA, Nishi R) Exp Cell Res 1997 Jun 15;233(2):350-62 PMID: 9194497 06/15/1997       49 Citations
  • Activin A and follistatin expression in developing targets of ciliary ganglion neurons suggests a role in regulating neurotransmitter phenotype. (Darland DC, Link BA, Nishi R) Neuron 1995 Oct;15(4):857-66 PMID: 7576634 10/01/1995       43 Citations
  • Last update: 08/28/2017
    jenkins-FCD Prod-300 626508253d14e4184314fb9f66322a03a5906796