Medical College of Wisconsin
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Brian A. Link PhD

Brian A. Link PhD


Institution: Medical College of Wisconsin
Department: Cell Biology, Neurobiology and Anatomy
Program: Administration

Member of the Cancer Center


  • Establishment of transgenic lines to monitor and manipulate Yap/Taz-Tead activity in zebrafish reveals both evolutionarily conserved and divergent functions of the Hippo pathway. (Miesfeld JB, Link BA) Mech Dev 2014 Aug;133:177-88 PMID 24560909
  • Mirror-symmetric microtubule assembly and cell interactions drive lumen formation in the zebrafish neural rod. (Buckley CE, Ren X, Ward LC, Girdler GC, Araya C, Green MJ, Clark BS, Link BA, Clarke JD) EMBO J 2013 Jan 9;32(1):30-44 PMID 23202854
  • Integrin α5/fibronectin1 and focal adhesion kinase are required for lens fiber morphogenesis in zebrafish. (Hayes JM, Hartsock A, Clark BS, Napier HR, Link BA, Gross JM) Mol Biol Cell 2012 Dec;23(24):4725-38 PMID 23097490
  • Loss of Llgl1 in retinal neuroepithelia reveals links between apical domain size, Notch activity and neurogenesis. (Clark BS, Cui S, Miesfeld JB, Klezovitch O, Vasioukhin V, Link BA) Development 2012 May;139(9):1599-610 PMID 22492354
  • Generation of Rab-based transgenic lines for in vivo studies of endosome biology in zebrafish. (Clark BS, Winter M, Cohen AR, Link BA) Dev Dyn 2011 Nov;240(11):2452-65 PMID 21976318
  • The ciliopathy gene cc2d2a controls zebrafish photoreceptor outer segment development through a role in Rab8-dependent vesicle trafficking. (Bachmann-Gagescu R, Phelps IG, Stearns G, Link BA, Brockerhoff SE, Moens CB, Doherty D) Hum Mol Genet 2011 Oct 15;20(20):4041-55 PMID 21816947
  • Cell biological regulation of division fate in vertebrate neuroepithelial cells. (Willardsen MI, Link BA) Dev Dyn 2011 Aug;240(8):1865-79 PMID 21761474
  • The visual system of zebrafish and its use to model human ocular diseases. (Gestri G, Link BA, Neuhauss SC) Dev Neurobiol 2012 Mar;72(3):302-27 PMID 21595048
  • Loss of Lrp2 in zebrafish disrupts pronephric tubular clearance but not forebrain development. (Kur E, Christa A, Veth KN, Gajera CR, Andrade-Navarro MA, Zhang J, Willer JR, Gregg RG, Abdelilah-Seyfried S, Bachmann S, Link BA, Hammes A, Willnow TE) Dev Dyn 2011 Jun;240(6):1567-77 PMID 21455927
  • Mutations in zebrafish lrp2 result in adult-onset ocular pathogenesis that models myopia and other risk factors for glaucoma. (Veth KN, Willer JR, Collery RF, Gray MP, Willer GB, Wagner DS, Mullins MC, Udvadia AJ, Smith RS, John SW, Gregg RG, Link BA) PLoS Genet 2011 Feb;7(2):e1001310 PMID 21379331
  • Dynamic smad-mediated BMP signaling revealed through transgenic zebrafish. (Collery RF, Link BA) Dev Dyn 2011 Mar;240(3):712-22 PMID 21337469
  • In vivo development of dendritic orientation in wild-type and mislocalized retinal ganglion cells. (Choi JH, Law MY, Chien CB, Link BA, Wong RO) Neural Dev 2010;5:29 PMID 21044295
  • Potential novel mechanism for Axenfeld-Rieger syndrome: deletion of a distant region containing regulatory elements of PITX2. (Volkmann BA, Zinkevich NS, Mustonen A, Schilter KF, Bosenko DV, Reis LM, Broeckel U, Link BA, Semina EV) Invest Ophthalmol Vis Sci 2011 Mar;52(3):1450-9 PMID 20881290
  • Analysis of a zebrafish dync1h1 mutant reveals multiple functions for cytoplasmic dynein 1 during retinal photoreceptor development. (Insinna C, Baye LM, Amsterdam A, Besharse JC, Link BA) Neural Dev 2010;5:12 PMID 20412557
  • Actomyosin is the main driver of interkinetic nuclear migration in the retina. (Norden C, Young S, Link BA, Harris WA) Cell 2009 Sep 18;138(6):1195-208 PMID 19766571
  • Lmx1b is essential for survival of periocular mesenchymal cells and influences Fgf-mediated retinal patterning in zebrafish. (McMahon C, Gestri G, Wilson SW, Link BA) Dev Biol 2009 Aug 15;332(2):287-98 PMID 19500562
  • FoxC1 is essential for vascular basement membrane integrity and hyaloid vessel morphogenesis. (Skarie JM, Link BA) Invest Ophthalmol Vis Sci 2009 Nov;50(11):5026-34 PMID 19458328
  • Apical membrane maturation and cellular rosette formation during morphogenesis of the zebrafish lateral line. (Hava D, Forster U, Matsuda M, Cui S, Link BA, Eichhorst J, Wiesner B, Chitnis A, Abdelilah-Seyfried S) J Cell Sci 2009 Mar 1;122(Pt 5):687-95 PMID 19208766
  • Analysis of IFT kinesins in developing zebrafish cone photoreceptor sensory cilia. (Insinna C, Luby-Phelps K, Link BA, Besharse JC) Methods Cell Biol 2009;93:219-34 PMID 20409820
  • The aqueous humor outflow pathway of zebrafish. (Gray MP, Smith RS, Soules KA, John SW, Link BA) Invest Ophthalmol Vis Sci 2009 Apr;50(4):1515-21 PMID 19060283
  • Regulation of neurogenesis by interkinetic nuclear migration through an apical-basal notch gradient. (Del Bene F, Wehman AM, Link BA, Baier H) Cell 2008 Sep 19;134(6):1055-65 PMID 18805097
  • Factorial microarray analysis of zebrafish retinal development. (Leung YF, Ma P, Link BA, Dowling JE) Proc Natl Acad Sci U S A 2008 Sep 2;105(35):12909-14 PMID 18753621
  • The primary open-angle glaucoma gene WDR36 functions in ribosomal RNA processing and interacts with the p53 stress-response pathway. (Skarie JM, Link BA) Hum Mol Genet 2008 Aug 15;17(16):2474-85 PMID 18469340
  • FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A. (Berry FB, Skarie JM, Mirzayans F, Fortin Y, Hudson TJ, Raymond V, Link BA, Walter MA) Hum Mol Genet 2008 Feb 15;17(4):490-505 PMID 17993506
  • Interkinetic nuclear migration and the selection of neurogenic cell divisions during vertebrate retinogenesis. (Baye LM, Link BA) J Neurosci 2007 Sep 19;27(38):10143-52 PMID 17881520
  • Nuclear migration during retinal development. (Baye LM, Link BA) Brain Res 2008 Feb 4;1192:29-36 PMID 17560964
  • The disarrayed mutation results in cell cycle and neurogenesis defects during retinal development in zebrafish. (Baye LM, Link BA) BMC Dev Biol 2007;7:28 PMID 17411431
  • Analysis of aPKClambda and aPKCzeta reveals multiple and redundant functions during vertebrate retinogenesis. (Cui S, Otten C, Rohr S, Abdelilah-Seyfried S, Link BA) Mol Cell Neurosci 2007 Mar;34(3):431-44 PMID 17223574
  • FGF19 is a target for FOXC1 regulation in ciliary body-derived cells. (Tamimi Y, Skarie JM, Footz T, Berry FB, Link BA, Walter MA) Hum Mol Genet 2006 Nov 1;15(21):3229-40 PMID 17000708
  • Mutations in laminin alpha 1 result in complex, lens-independent ocular phenotypes in zebrafish. (Semina EV, Bosenko DV, Zinkevich NC, Soules KA, Hyde DR, Vihtelic TS, Willer GB, Gregg RG, Link BA) Dev Biol 2006 Nov 1;299(1):63-77 PMID 16973147
  • laminin alpha 1 gene is essential for normal lens development in zebrafish. (Zinkevich NS, Bosenko DV, Link BA, Semina EV) BMC Dev Biol 2006;6:13 PMID 16522196
  • Morphogenesis of the anterior segment in the zebrafish eye. (Soules KA, Link BA) BMC Dev Biol 2005;5:12 PMID 15985175
  • Analysis of the Zebrafish perplexed mutation reveals tissue-specific roles for de novo pyrimidine synthesis during development. (Willer GB, Lee VM, Gregg RG, Link BA) Genetics 2005 Aug;170(4):1827-37 PMID 15937129
  • Staggered cell-intrinsic timing of ath5 expression underlies the wave of ganglion cell neurogenesis in the zebrafish retina. (Kay JN, Link BA, Baier H) Development 2005 Jun;132(11):2573-85 PMID 15857917
  • dazed gene is necessary for late cell type development and retinal cell maintenance in the zebrafish retina. (Perkins BD, Nicholas CS, Baye LM, Link BA, Dowling JE) Dev Dyn 2005 Jun;233(2):680-94 PMID 15844196
  • Intraocular pressure in zebrafish: comparison of inbred strains and identification of a reduced melanin mutant with raised IOP. (Link BA, Gray MP, Smith RS, John SW) Invest Ophthalmol Vis Sci 2004 Dec;45(12):4415-22 PMID 15557450
  • Using zebrafish to study the complex genetics of glaucoma. (McMahon C, Semina EV, Link BA) Comp Biochem Physiol C Toxicol Pharmacol 2004 Jul;138(3):343-50 PMID 15533792
  • Positional cloning of the young mutation identifies an essential role for the Brahma chromatin remodeling complex in mediating retinal cell differentiation. (Gregg RG, Willer GB, Fadool JM, Dowling JE, Link BA) Proc Natl Acad Sci U S A 2003 May 27;100(11):6535-40 PMID 12748389
  • Suppression of lens growth by alphaA-crystallin promoter-driven expression of diphtheria toxin results in disruption of retinal cell organization in zebrafish. (Kurita R, Sagara H, Aoki Y, Link BA, Arai K, Watanabe S) Dev Biol 2003 Mar 1;255(1):113-27 PMID 12618137
  • Evidence for directed mitotic cleavage plane reorientations during retinal development within the zebrafish. (Link BA) Biol Bull 2001 Oct;201(2):254-5 PMID 11687408
  • The perplexed and confused mutations affect distinct stages during the transition from proliferating to post-mitotic cells within the zebrafish retina. (Link BA, Kainz PM, Ryou T, Dowling JE) Dev Biol 2001 Aug 15;236(2):436-53 PMID 11476583
  • Genetic analysis of initial and ongoing retinogenesis in the zebrafish: comparing the central neuroepithelium and marginal zone. (Link BA, Darland T) Prog Brain Res 2001;131:565-77 PMID 11420971
  • Small molecule developmental screens reveal the logic and timing of vertebrate development. (Peterson RT, Link BA, Dowling JE, Schreiber SL) Proc Natl Acad Sci U S A 2000 Nov 21;97(24):12965-9 PMID 11087852
  • The zebrafish young mutation acts non-cell-autonomously to uncouple differentiation from specification for all retinal cells. (Link BA, Fadool JM, Malicki J, Dowling JE) Development 2000 May;127(10):2177-88 PMID 10769241
  • Development of the avian iris and ciliary body: mechanisms of cellular differentiation during the smooth-to-striated muscle transition. (Link BA, Nishi R) Dev Biol 1998 Nov 1;203(1):163-76 PMID 9806781
  • Development of the avian iris and ciliary body: the role of activin and follistatin in coordination of the smooth-to-striated muscle transition. (Link BA, Nishi R) Dev Biol 1998 Jul 15;199(2):226-34 PMID 9698442
  • Opposing effects of activin A and follistatin on developing skeletal muscle cells. (Link BA, Nishi R) Exp Cell Res 1997 Jun 15;233(2):350-62 PMID 9194497
  • Activin A and follistatin expression in developing targets of ciliary ganglion neurons suggests a role in regulating neurotransmitter phenotype. (Darland DC, Link BA, Nishi R) Neuron 1995 Oct;15(4):857-66 PMID 7576634
  • Grants and Awards

  • Molecular Genetics of High Myopia (#9209005 12/01/2014 - 04/30/2015) Sponsor: University of Wisconsin-Madison
  • Analysis of Glaucoma Gene Interactions (#9203517 12/01/2004 - 07/31/2010) Sponsor: NIH Eye Institute
  • Signaling and Gene Interactions Underlying Glaucoma Risk Phenotypes (#9207038 08/01/2011 - 06/30/2016) Sponsor: NIH Eye Institute
  • Integrative Analyis of Vertebrate Retinal Lamination (#9208454 02/01/2014 - 01/31/2018) Sponsor: NIH Eye Institute
  • Last update: 04/27/2014