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Medical College of Wisconsin

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Kirkwood A. Pritchard PhD

Professor

Institution: Medical College of Wisconsin
Department: Surgery
Division: Pediatric Surgery

Member of the Cancer Center
Member of the Cardiovascular Center

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Publications

Myeloperoxidase: A new player in autoimmunity. (Strzepa A, Pritchard KA, Dittel BN) Cell Immunol 2017 Jul;317:1-8 PMID: 28511921 PMCID: PMC5665680 05/18/2017 12 Citations

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice. (Weihrauch D, Krolikowski JG, Jones DW, Zaman T, Bamkole O, Struve J, Pagel PS, Lohr NL, Pritchard KA Jr) J Vis Exp 2017 03 24(121) PMID: 28362381 PMCID: PMC5408651 04/01/2017

Domain Mapping of Heat Shock Protein 70 Reveals That Glutamic Acid 446 and Arginine 447 Are Critical for Regulating Superoxide Dismutase 2 Function. (Afolayan AJ, Alexander M, Holme RL, Michalkiewicz T, Rana U, Teng RJ, Zemanovic S, Sahoo D, Pritchard KA Jr, Konduri GG) J Biol Chem 2017 02 10;292(6):2369-2378 PMID: 28028182 PMCID: PMC5313107 12/29/2016 2 Citations

Erratum to: Inhibition of myeloperoxidase oxidant production by N-acetyl lysyltyrosylcysteine amide reduces brain damage in a murine model of stroke. (Yu G, Liang Y, Huang Z, Jones DW, Pritchard KA Jr, Zhang H) J Neuroinflammation 2016 Jun 27;13(1):166 PMID: 27349966 PMCID: PMC4924260 06/29/2016

Inhibition of myeloperoxidase oxidant production by N-acetyl lysyltyrosylcysteine amide reduces brain damage in a murine model of stroke. (Yu G, Liang Y, Huang Z, Jones DW, Pritchard KA Jr, Zhang H) J Neuroinflammation 2016 05 24;13(1):119 PMID: 27220420 PMCID: PMC4879722 05/26/2016 13 Citations

An IRF5 Decoy Peptide Reduces Myocardial Inflammation and Fibrosis and Improves Endothelial Cell Function in Tight-Skin Mice. (Weihrauch D, Krolikowski JG, Jones DW, Zaman T, Bamkole O, Struve J, Pillai S, Pagel PS, Lohr NL, Pritchard KA Jr) PLoS One 2016;11(4):e0151999 PMID: 27050551 PMCID: PMC4822818 04/07/2016 4 Citations

Inhibition of myeloperoxidase at the peak of experimental autoimmune encephalomyelitis restores blood-brain barrier integrity and ameliorates disease severity. (Zhang H, Ray A, Miller NM, Hartwig D, Pritchard KA, Dittel BN) J Neurochem 2016 Feb;136(4):826-836 PMID: 26560636 PMCID: PMC4865458 11/13/2015

Cumulative Brain Injury from Motor Vehicle-Induced Whole-Body Vibration and Prevention by Human Apolipoprotein A-I Molecule Mimetic (4F) Peptide (an Apo A-I Mimetic). (Yan JG, Zhang LL, Agresti M, Yan Y, LoGiudice J, Sanger JR, Matloub HS, Pritchard KA Jr, Jaradeh SS, Havlik R) J Stroke Cerebrovasc Dis 2015 Dec;24(12):2759-73 PMID: 26433438 PMCID: PMC5664147 10/05/2015

Interaction of endothelial nitric oxide synthase with mitochondria regulates oxidative stress and function in fetal pulmonary artery endothelial cells. (Konduri GG, Afolayan AJ, Eis A, Pritchard KA Jr, Teng RJ) Am J Physiol Lung Cell Mol Physiol 2015 Nov 01;309(9):L1009-17 PMID: 26320159 PMCID: PMC4628983 09/01/2015 3 Citations

A novel path of improving heart function after infarction. (Pritchard KA Jr, Weihrauch D) J Mol Cell Cardiol 2015 Jul;84:200-1 PMID: 25944086 PMCID: PMC5665170 05/07/2015

Acrolein impairs the cholesterol transport functions of high density lipoproteins. (Chadwick AC, Holme RL, Chen Y, Thomas MJ, Sorci-Thomas MG, Silverstein RL, Pritchard KA Jr, Sahoo D) PLoS One 2015;10(4):e0123138 PMID: 25849485 PMCID: PMC4388475 04/08/2015 10 Citations

Intestinal NADPH oxidase 2 activity increases in a neonatal rat model of necrotizing enterocolitis. (Welak SR, Rentea RM, Teng RJ, Heinzerling N, Biesterveld B, Liedel JL, Pritchard KA Jr, Fredrich KM, Gourlay DM) PLoS One 2014;9(12):e115317 PMID: 25517730 PMCID: PMC4269454 12/18/2014 3 Citations

Sickle cell disease increases high mobility group box 1: a novel mechanism of inflammation. (Xu H, Wandersee NJ, Guo Y, Jones DW, Holzhauer SL, Hanson MS, Machogu E, Brousseau DC, Hogg N, Densmore JC, Kaul S, Hillery CA, Pritchard KA Jr) Blood 2014 Dec 18;124(26):3978-81 PMID: 25339362 PMCID: PMC4271182 10/24/2014 12 Citations

Intestinal alkaline phosphatase is protective to the preterm rat pup intestine. (Heinzerling NP, Liedel JL, Welak SR, Fredrich K, Biesterveld BE, Pritchard KA Jr, Gourlay DM) J Pediatr Surg 2014 Jun;49(6):954-60; discussion 960 PMID: 24888842 PMCID: PMC4130394 06/04/2014 12 Citations

The role of neutrophil myeloperoxidase in models of lung tumor development. (Rymaszewski AL, Tate E, Yimbesalu JP, Gelman AE, Jarzembowski JA, Zhang H, Pritchard KA Jr, Vikis HG) Cancers (Basel) 2014 May 09;6(2):1111-27 PMID: 24821130 PMCID: PMC4074819 05/14/2014

Association of pro-inflammatory high-density lipoprotein cholesterol with clinical and laboratory variables in sickle cell disease. (Ataga KI, Hinderliter A, Brittain JE, Jones S, Xu H, Cai J, Kim S, Pritchard KA, Hillery CA) Hematology 2015 Jun;20(5):289-96 PMID: 24801127 PMCID: PMC4223013 05/08/2014 7 Citations

Anion exchange HPLC isolation of high-density lipoprotein (HDL) and on-line estimation of proinflammatory HDL. (Ji X, Xu H, Zhang H, Hillery CA, Gao HQ, Pritchard KA Jr) PLoS One 2014;9(3):e91089 PMID: 24609013 PMCID: PMC3946658 03/13/2014 6 Citations

Enoyl coenzyme a hydratase domain-containing 2, a potential novel regulator of myocardial ischemia injury. (Du J, Li Z, Li QZ, Guan T, Yang Q, Xu H, Pritchard KA, Camara AK, Shi Y) J Am Heart Assoc 2013 Oct 09;2(5):e000233 PMID: 24108764 PMCID: PMC3835224 10/11/2013 6 Citations

Inhibition of myeloperoxidase decreases vascular oxidative stress and increases vasodilatation in sickle cell disease mice. (Zhang H, Xu H, Weihrauch D, Jones DW, Jing X, Shi Y, Gourlay D, Oldham KT, Hillery CA, Pritchard KA Jr) J Lipid Res 2013 Nov;54(11):3009-15 PMID: 23956444 PMCID: PMC3793605 08/21/2013 19 Citations

N-acetyl lysyltyrosylcysteine amide inhibits myeloperoxidase, a novel tripeptide inhibitor. (Zhang H, Jing X, Shi Y, Xu H, Du J, Guan T, Weihrauch D, Jones DW, Wang W, Gourlay D, Oldham KT, Hillery CA, Pritchard KA Jr) J Lipid Res 2013 Nov;54(11):3016-29 PMID: 23883583 PMCID: PMC3793606 07/26/2013 15 Citations

Rattus model utilizing selective pulmonary ischemia induces bronchiolitis obliterans organizing pneumonia. (Densmore JC, Jeziorczak PM, Clough AV, Pritchard KA Jr, Cummens B, Medhora M, Rao A, Jacobs ER) Shock 2013 Mar;39(3):271-7 PMID: 23364425 PMCID: PMC3578046 02/01/2013 7 Citations

4F decreases IRF5 expression and activation in hearts of tight skin mice. (Xu H, Krolikowski JG, Jones DW, Ge ZD, Pagel PS, Pritchard KA Jr, Weihrauch D) PLoS One 2012;7(12):e52046 PMID: 23251680 PMCID: PMC3522636 12/20/2012 10 Citations

Transient repetitive exposure to low level light therapy enhances collateral blood vessel growth in the ischemic hindlimb of the tight skin mouse. (Zaidi M, Krolikowki JG, Jones DW, Pritchard KA Jr, Struve J, Nandedkar SD, Lohr NL, Pagel PS, Weihrauch D) Photochem Photobiol 2013 May-Jun;89(3):709-13 PMID: 23231468 PMCID: PMC3597754 12/13/2012 12 Citations

Early enteral stressors in newborns increase inflammatory cytokine expression in a neonatal necrotizing enterocolitis rat model. (Rentea RM, Welak SR, Fredrich K, Donohoe D, Pritchard KA, Oldham KT, Gourlay DM, Liedel JL) Eur J Pediatr Surg 2013 Feb;23(1):39-47 PMID: 23165517 PMCID: PMC5664148 11/21/2012 11 Citations

Intestinal alkaline phosphatase prevents the systemic inflammatory response associated with necrotizing enterocolitis. (Riggle KM, Rentea RM, Welak SR, Pritchard KA Jr, Oldham KT, Gourlay DM) J Surg Res 2013 Mar;180(1):21-6 PMID: 23158403 PMCID: PMC5664146 11/20/2012 17 Citations

A novel hemoglobin-binding peptide reduces cell-free hemoglobin in murine hemolytic anemia. (Hanson MS, Xu H, Flewelen TC, Holzhauer SL, Retherford D, Jones DW, Frei AC, Pritchard KA Jr, Hillery CA, Hogg N, Wandersee NJ) Am J Physiol Heart Circ Physiol 2013 Jan 15;304(2):H328-36 PMID: 23125208 PMCID: PMC3543667 11/06/2012 7 Citations

Intestinal alkaline phosphatase administration in newborns is protective of gut barrier function in a neonatal necrotizing enterocolitis rat model. (Rentea RM, Liedel JL, Welak SR, Cassidy LD, Mayer AN, Pritchard KA Jr, Oldham KT, Gourlay DM) J Pediatr Surg 2012 Jun;47(6):1135-42 PMID: 22703783 06/19/2012 27 Citations

Intestinal alkaline phosphatase administration in newborns decreases systemic inflammatory cytokine expression in a neonatal necrotizing enterocolitis rat model. (Rentea RM, Liedel JL, Fredrich K, Welak SR, Pritchard KA Jr, Oldham KT, Simpson PM, Gourlay DM) J Surg Res 2012 Oct;177(2):228-34 PMID: 22687880 PMCID: PMC5664150 06/13/2012 8 Citations

The preventive effects of apolipoprotein mimetic D-4F from vibration injury-experiment in rats. (Rowe DJ, Yan JG, Zhang LL, Pritchard KA Jr, Kao DS, Matloub HS, Riley DA) Hand (N Y) 2011 Mar;6(1):64-70 PMID: 22379441 PMCID: PMC3041892 03/02/2012

Effects of experimental asthma on inflammation and lung mechanics in sickle cell mice. (Pritchard KA Jr, Feroah TR, Nandedkar SD, Holzhauer SL, Hutchins W, Schulte ML, Strunk RC, Debaun MR, Hillery CA) Am J Respir Cell Mol Biol 2012 Mar;46(3):389-96 PMID: 22033263 PMCID: PMC3326430 10/29/2011 17 Citations

Sepiapterin improves angiogenesis of pulmonary artery endothelial cells with in utero pulmonary hypertension by recoupling endothelial nitric oxide synthase. (Teng RJ, Du J, Xu H, Bakhutashvili I, Eis A, Shi Y, Pritchard KA Jr, Konduri GG) Am J Physiol Lung Cell Mol Physiol 2011 Sep;301(3):L334-45 PMID: 21622842 PMCID: PMC3174740 05/31/2011 23 Citations

Resistance and aerobic exercise protects against acute endothelial impairment induced by a single exposure to hypertension during exertion. (Phillips SA, Das E, Wang J, Pritchard K, Gutterman DD) J Appl Physiol (1985) 2011 Apr;110(4):1013-20 PMID: 21252216 PMCID: PMC3075126 01/22/2011 52 Citations

Abnormal fibrillin-1 expression and chronic oxidative stress mediate endothelial mesenchymal transition in a murine model of systemic sclerosis. (Xu H, Zaidi M, Struve J, Jones DW, Krolikowski JG, Nandedkar S, Lohr NL, Gadicherla A, Pagel PS, Csuka ME, Pritchard KA, Weihrauch D) Am J Physiol Cell Physiol 2011 Mar;300(3):C550-6 PMID: 21160034 PMCID: PMC3063974 12/17/2010 25 Citations

D-4F, an apoA-1 mimetic, decreases airway hyperresponsiveness, inflammation, and oxidative stress in a murine model of asthma. (Nandedkar SD, Weihrauch D, Xu H, Shi Y, Feroah T, Hutchins W, Rickaby DA, Duzgunes N, Hillery CA, Konduri KS, Pritchard KA Jr) J Lipid Res 2011 Mar;52(3):499-508 PMID: 21131532 PMCID: PMC3035686 12/07/2010 39 Citations

Nitrotyrosine impairs angiogenesis and uncouples eNOS activity of pulmonary artery endothelial cells isolated from developing sheep lungs. (Teng RJ, Wu TJ, Bisig CG, Eis A, Pritchard KA, Konduri GG) Pediatr Res 2011 Feb;69(2):112-7 PMID: 21057377 PMCID: PMC3086583 11/09/2010 7 Citations

Endothelial microparticles induce inflammation in acute lung injury. (Buesing KL, Densmore JC, Kaul S, Pritchard KA Jr, Jarzembowski JA, Gourlay DM, Oldham KT) J Surg Res 2011 Mar;166(1):32-9 PMID: 20828748 PMCID: PMC4731030 09/11/2010 35 Citations

The protective role of intestinal alkaline phosphatase in necrotizing enterocolitis. (Whitehouse JS, Riggle KM, Purpi DP, Mayer AN, Pritchard KA Jr, Oldham KT, Gourlay DM) J Surg Res 2010 Sep;163(1):79-85 PMID: 20599220 07/06/2010 30 Citations

Genetic deletion of apolipoprotein A-I increases airway hyperresponsiveness, inflammation, and collagen deposition in the lung. (Wang W, Xu H, Shi Y, Nandedkar S, Zhang H, Gao H, Feroah T, Weihrauch D, Schulte ML, Jones DW, Jarzembowski J, Sorci-Thomas M, Pritchard KA Jr) J Lipid Res 2010 Sep;51(9):2560-70 PMID: 20498409 PMCID: PMC2918439 05/26/2010 49 Citations

Increased resistance to LPS-induced myocardial dysfunction in the Brown Norway rats versus Dahl S rats: roles of inflammatory cytokines and nuclear factor kappaB pathway. (Du J, An J, Wei N, Guan T, Pritchard KA Jr, Shi Y) Shock 2010 Mar;33(3):332-6 PMID: 20160611 PMCID: PMC3193159 02/18/2010 12 Citations

Mesenteric nitric oxide and superoxide production in experimental necrotizing enterocolitis. (Whitehouse JS, Xu H, Shi Y, Noll L, Kaul S, Jones DW, Pritchard KA Jr, Oldham KT, Gourlay DM) J Surg Res 2010 Jun 01;161(1):1-8 PMID: 19922948 PMCID: PMC3196648 11/20/2009 28 Citations

Identification and functional characterization of phosphorylation sites on GTP cyclohydrolase I. (Du J, Wei N, Xu H, Ge Y, Vásquez-Vivar J, Guan T, Oldham KT, Pritchard KA Jr, Shi Y) Arterioscler Thromb Vasc Biol 2009 Dec;29(12):2161-8 PMID: 19762783 PMCID: PMC2798731 09/19/2009 8 Citations

Role of tetrahydrobiopterin in resistance to myocardial ischemia in Brown Norway and Dahl S rats. (An J, Du J, Wei N, Xu H, Pritchard KA Jr, Shi Y) Am J Physiol Heart Circ Physiol 2009 Nov;297(5):H1783-91 PMID: 19717731 PMCID: PMC2781371 09/01/2009 10 Citations

Inhibition of CDKS by roscovitine suppressed LPS-induced *NO production through inhibiting NFkappaB activation and BH4 biosynthesis in macrophages. (Du J, Wei N, Guan T, Xu H, An J, Pritchard KA Jr, Shi Y) Am J Physiol Cell Physiol 2009 Sep;297(3):C742-9 PMID: 19553566 PMCID: PMC2740392 06/26/2009 26 Citations

Identification of proteins interacting with GTP cyclohydrolase I. (Du J, Xu H, Wei N, Wakim B, Halligan B, Pritchard KA Jr, Shi Y) Biochem Biophys Res Commun 2009 Jul 24;385(2):143-7 PMID: 19442649 PMCID: PMC2737525 05/16/2009 8 Citations

Bradykinin-induced dilation of human coronary arterioles requires NADPH oxidase-derived reactive oxygen species. (Larsen BT, Bubolz AH, Mendoza SA, Pritchard KA Jr, Gutterman DD) Arterioscler Thromb Vasc Biol 2009 May;29(5):739-45 PMID: 19213944 PMCID: PMC2727937 02/14/2009 47 Citations

Targeted increases in endothelial cell superoxide anion production stimulate eNOS-dependent nitric oxide production, not uncoupled eNOS activity. (Xu H, Pritchard KA Jr) Arterioscler Thromb Vasc Biol 2008 Sep;28(9):1580-1 PMID: 18716321 08/22/2008

Protein composition of plasminogen activator inhibitor type 1-derived endothelial microparticles. (Sander TL, Ou JS, Densmore JC, Kaul S, Matus I, Twigger S, Halligan B, Greene AS, Pritchard KA Jr, Oldham KT) Shock 2008 Apr;29(4):504-11 PMID: 18598005 07/04/2008 17 Citations

Histopathology of experimentally induced asthma in a murine model of sickle cell disease. (Nandedkar SD, Feroah TR, Hutchins W, Weihrauch D, Konduri KS, Wang J, Strunk RC, DeBaun MR, Hillery CA, Pritchard KA) Blood 2008 Sep 15;112(6):2529-38 PMID: 18579795 PMCID: PMC2532817 06/27/2008 33 Citations

Comparative proteomic analysis of PAI-1 and TNF-alpha-derived endothelial microparticles. (Peterson DB, Sander T, Kaul S, Wakim BT, Halligan B, Twigger S, Pritchard KA Jr, Oldham KT, Ou JS) Proteomics 2008 Jun;8(12):2430-46 PMID: 18563738 PMCID: PMC4753841 06/20/2008 99 Citations

Vascular dysfunction in a murine model of severe hemolysis. (Frei AC, Guo Y, Jones DW, Pritchard KA Jr, Fagan KA, Hogg N, Wandersee NJ) Blood 2008 Jul 15;112(2):398-405 PMID: 18477769 PMCID: PMC2442749 05/15/2008 31 Citations

Surfactant protein D: not just for the lung anymore. (Pritchard KA Jr) Am J Physiol Heart Circ Physiol 2008 May;294(5):H1994 PMID: 18390823 04/09/2008 2 Citations

20-hydroxyeicosatetraenoic acid causes endothelial dysfunction via eNOS uncoupling. (Cheng J, Ou JS, Singh H, Falck JR, Narsimhaswamy D, Pritchard KA Jr, Schwartzman ML) Am J Physiol Heart Circ Physiol 2008 Feb;294(2):H1018-26 PMID: 18156192 12/25/2007 105 Citations

A heat shock protein 90 binding domain in endothelial nitric-oxide synthase influences enzyme function. (Xu H, Shi Y, Wang J, Jones D, Weilrauch D, Ying R, Wakim B, Pritchard KA Jr) J Biol Chem 2007 Dec 28;282(52):37567-74 PMID: 17971446 11/01/2007 45 Citations

PROTEIN COMPOSITION OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE 1-DERIVED ENDOTHELIAL MICROPARTICLES. (Sander TL et al.) Shock 2007 Aug 16;Publish Ahead of Print: PMID: 17704734 08/21/2007

Effects of D-4F on vasodilation, oxidative stress, angiostatin, myocardial inflammation, and angiogenic potential in tight-skin mice. (Weihrauch D, Xu H, Shi Y, Wang J, Brien J, Jones DW, Kaul S, Komorowski RA, Csuka ME, Oldham KT, Pritchard KA) Am J Physiol Heart Circ Physiol 2007 Sep;293(3):H1432-41 PMID: 17496220 05/15/2007 59 Citations

Endothelium-derived microparticles induce endothelial dysfunction and acute lung injury. (Densmore JC, Signorino PR, Ou J, Hatoum OA, Rowe JJ, Shi Y, Kaul S, Jones DW, Sabina RE, Pritchard KA Jr, Guice KS, Oldham KT) Shock 2006 Nov;26(5):464-71 PMID: 17047516 10/19/2006 82 Citations

Rosiglitazone antagonizes vascular endothelial growth factor signaling and nuclear factor of activated T cells activation in cardiac valve endothelium. (Sander TL, Noll L, Klinkner DB, Weihrauch D, He BJ, Kaul S, Zangwill SD, Tweddell JS, Pritchard KA Jr, Oldham KT) Endothelium 2006 May-Jun;13(3):181-90 PMID: 16840174 07/15/2006 6 Citations

Endothelium-derived microparticles inhibit human cardiac valve endothelial cell function. (Klinkner DB, Densmore JC, Kaul S, Noll L, Lim HJ, Weihrauch D, Pritchard KA Jr, Oldham KT, Sander TL) Shock 2006 Jun;25(6):575-80 PMID: 16721264 05/25/2006 41 Citations

Mechanisms of activation of eNOS by 20-HETE and VEGF in bovine pulmonary artery endothelial cells. (Chen Y, Medhora M, Falck JR, Pritchard KA Jr, Jacobs ER) Am J Physiol Lung Cell Mol Physiol 2006 Sep;291(3):L378-85 PMID: 16679377 05/09/2006 44 Citations

BN phenome: detailed characterization of the cardiovascular, renal, and pulmonary systems of the sequenced rat. (Kwitek AE, Jacob HJ, Baker JE, Dwinell MR, Forster HV, Greene AS, Kunert MP, Lombard JH, Mattson DL, Pritchard KA Jr, Roman RJ, Tonellato PJ, Cowley AW Jr) Physiol Genomics 2006 Apr 13;25(2):303-13 PMID: 16478827 02/16/2006 26 Citations

Effects of D-4F on vasodilation and vessel wall thickness in hypercholesterolemic LDL receptor-null and LDL receptor/apolipoprotein A-I double-knockout mice on Western diet. (Ou J, Wang J, Xu H, Ou Z, Sorci-Thomas MG, Jones DW, Signorino P, Densmore JC, Kaul S, Oldham KT, Pritchard KA Jr) Circ Res 2005 Nov 25;97(11):1190-7 PMID: 16224061 PMCID: PMC1480357 10/15/2005 92 Citations

Tetrahydrobiopterin in pulmonary hypertension: pulmonary hypertension in guanosine triphosphate-cyclohydrolase-deficient mice. (Pritchard KA Jr, Shi Y, Konduri GG) Circulation 2005 Apr 26;111(16):2022-4 PMID: 15851611 04/27/2005 6 Citations

Increased resistance to myocardial ischemia in the Brown Norway vs. Dahl S rat: role of nitric oxide synthase and Hsp90. (Shi Y, Hutchins W, Ogawa H, Chang CC, Pritchard KA Jr, Zhang C, Khampang P, Lazar J, Jacob HJ, Rafiee P, Baker JE) J Mol Cell Cardiol 2005 Apr;38(4):625-35 PMID: 15808839 04/06/2005 29 Citations

Erythropoietin protects the infant heart against ischemia-reperfusion injury by triggering multiple signaling pathways. (Rafiee P, Shi Y, Su J, Pritchard KA Jr, Tweddell JS, Baker JE) Basic Res Cardiol 2005 May;100(3):187-97 PMID: 15611843 12/22/2004 92 Citations

Delayed cardioprotection with isoflurane: role of reactive oxygen and nitrogen. (Shi Y, Hutchins WC, Su J, Siker D, Hogg N, Pritchard KA Jr, Keszler A, Tweddell JS, Baker JE) Am J Physiol Heart Circ Physiol 2005 Jan;288(1):H175-84 PMID: 15388508 09/25/2004 34 Citations

Alpha phenyl-tert-butyl nitrone (PBN) protects syngeneic marrow transplant recipients from the lethal cytokine syndrome occurring after agonistic CD40 antibody administration. (Gendelman M, Halligan N, Komorowski R, Logan B, Murphy WJ, Blazar BR, Pritchard KA Jr, Drobyski WR) Blood 2005 Jan 01;105(1):428-31 PMID: 15331451 08/28/2004 8 Citations

Acute cardioprotective effects of erythropoietin in infant rabbits are mediated by activation of protein kinases and potassium channels. (Shi Y, Rafiee P, Su J, Pritchard KA Jr, Tweddell JS, Baker JE) Basic Res Cardiol 2004 May;99(3):173-82 PMID: 15088102 04/17/2004 76 Citations

Heat shock protein 90 and tyrosine kinase regulate eNOS NO* generation but not NO* bioactivity. (Ou J, Fontana JT, Ou Z, Jones DW, Ackerman AW, Oldham KT, Yu J, Sessa WC, Pritchard KA Jr) Am J Physiol Heart Circ Physiol 2004 Feb;286(2):H561-9 PMID: 14551044 10/11/2003 47 Citations

Hypoxia-induced acute lung injury in murine models of sickle cell disease. (Pritchard KA Jr, Ou J, Ou Z, Shi Y, Franciosi JP, Signorino P, Kaul S, Ackland-Berglund C, Witte K, Holzhauer S, Mohandas N, Guice KS, Oldham KT, Hillery CA) Am J Physiol Lung Cell Mol Physiol 2004 Apr;286(4):L705-14 PMID: 12972407 09/16/2003 53 Citations

Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production. (Lin MI, Fulton D, Babbitt R, Fleming I, Busse R, Pritchard KA Jr, Sessa WC) J Biol Chem 2003 Nov 07;278(45):44719-26 PMID: 12952971 09/04/2003 181 Citations

Cellular redistribution of inducible Hsp70 protein in the human and rabbit heart in response to the stress of chronic hypoxia: role of protein kinases,. (Rafiee P, Shi Y, Pritchard KA Jr, Ogawa H, Eis AL, Komorowski RA, Fitzpatrick CM, Tweddell JS, Litwin SB, Mussatto K, Jaquiss RD, Baker JE) J Biol Chem 2003 Oct 31;278(44):43636-44 PMID: 12937165 08/26/2003 44 Citations

Mechanisms of endotoxin tolerance in human intestinal microvascular endothelial cells. (Ogawa H, Rafiee P, Heidemann J, Fisher PJ, Johnson NA, Otterson MF, Kalyanaraman B, Pritchard KA Jr, Binion DG) J Immunol 2003 Jun 15;170(12):5956-64 PMID: 12794122 06/10/2003 54 Citations

AP-4F, antennapedia peptide linked to an amphipathic alpha helical peptide, increases the efficiency of Lipofectamine-mediated gene transfection in endothelial cells. (Ou J, Geiger T, Ou Z, Ackerman AW, Oldham KT, Pritchard KA Jr) Biochem Biophys Res Commun 2003 Jun 06;305(3):605-10 PMID: 12763037 05/24/2003 14 Citations

L-4F, an apolipoprotein A-1 mimetic, dramatically improves vasodilation in hypercholesterolemia and sickle cell disease. (Ou J, Ou Z, Jones DW, Holzhauer S, Hatoum OA, Ackerman AW, Weihrauch DW, Gutterman DD, Guice K, Oldham KT, Hillery CA, Pritchard KA Jr) Circulation 2003 May 13;107(18):2337-41 PMID: 12732610 05/07/2003 116 Citations

Decreased association of HSP90 impairs endothelial nitric oxide synthase in fetal lambs with persistent pulmonary hypertension. (Konduri GG, Ou J, Shi Y, Pritchard KA Jr) Am J Physiol Heart Circ Physiol 2003 Jul;285(1):H204-11 PMID: 12663260 03/29/2003 72 Citations

Trichloroethylene decreases heat shock protein 90 interactions with endothelial nitric oxide synthase: implications for endothelial cell proliferation. (Ou J, Ou Z, McCarver DG, Hines RN, Oldham KT, Ackerman AW, Pritchard KA Jr) Toxicol Sci 2003 May;73(1):90-7 PMID: 12657742 03/27/2003 31 Citations

L-4F, an apolipoprotein A-1 mimetic, restores nitric oxide and superoxide anion balance in low-density lipoprotein-treated endothelial cells. (Ou Z, Ou J, Ackerman AW, Oldham KT, Pritchard KA Jr) Circulation 2003 Mar 25;107(11):1520-4 PMID: 12654610 03/26/2003 84 Citations

Angiostatin: a negative regulator of endothelial-dependent vasodilation. (Koshida R, Ou J, Matsunaga T, Chilian WM, Oldham KT, Ackerman AW, Pritchard KA Jr) Circulation 2003 Feb 18;107(6):803-6 PMID: 12591747 02/20/2003 49 Citations

Inhibition of heat shock protein 90 (hsp90) in proliferating endothelial cells uncouples endothelial nitric oxide synthase activity. (Ou J, Ou Z, Ackerman AW, Oldham KT, Pritchard KA Jr) Free Radic Biol Med 2003 Jan 15;34(2):269-76 PMID: 12521608 01/11/2003 50 Citations

Chronic hypoxia increases endothelial nitric oxide synthase generation of nitric oxide by increasing heat shock protein 90 association and serine phosphorylation. (Shi Y, Baker JE, Zhang C, Tweddell JS, Su J, Pritchard KA Jr) Circ Res 2002 Aug 23;91(4):300-6 PMID: 12193462 08/24/2002 85 Citations

Native LDL and minimally oxidized LDL differentially regulate superoxide anion in vascular endothelium in situ. (Stepp DW, Ou J, Ackerman AW, Welak S, Klick D, Pritchard KA Jr) Am J Physiol Heart Circ Physiol 2002 Aug;283(2):H750-9 PMID: 12124224 07/19/2002 65 Citations

Activation of protein kinases in chronically hypoxic infant human and rabbit hearts: role in cardioprotection. (Rafiee P, Shi Y, Kong X, Pritchard KA Jr, Tweddell JS, Litwin SB, Mussatto K, Jaquiss RD, Su J, Baker JE) Circulation 2002 Jul 09;106(2):239-45 PMID: 12105165 07/10/2002 69 Citations

Native low-density lipoprotein induces endothelial nitric oxide synthase dysfunction: role of heat shock protein 90 and caveolin-1. (Pritchard KA, Ackerman AW, Ou J, Curtis M, Smalley DM, Fontana JT, Stemerman MB, Sessa WC) Free Radic Biol Med 2002 Jul 01;33(1):52-62 PMID: 12086682 06/28/2002 40 Citations

Protein kinase B/Akt activates c-Jun NH(2)-terminal kinase by increasing NO production in response to shear stress. (Go YM, Boo YC, Park H, Maland MC, Patel R, Pritchard KA Jr, Fujio Y, Walsh K, Darley-Usmar V, Jo H) J Appl Physiol (1985) 2001 Oct;91(4):1574-81 PMID: 11568138 09/25/2001 82 Citations

Attenuated expression of inducible nitric oxide synthase in lung microvascular endothelial cells is associated with an increase in ICAM-1 expression. (Lo HP, Ackland-Berglund CE, Pritchard KA Jr, Guice KS, Oldham KT) J Pediatr Surg 2001 Aug;36(8):1136-42 PMID: 11479842 08/02/2001 16 Citations

Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase. (Pritchard KA Jr, Ackerman AW, Gross ER, Stepp DW, Shi Y, Fontana JT, Baker JE, Sessa WC) J Biol Chem 2001 May 25;276(21):17621-4 PMID: 11278264 03/30/2001 253 Citations

Chronic myocardial hypoxia increases nitric oxide synthase and decreases caveolin-3. (Shi Y, Pritchard KA Jr, Holman P, Rafiee P, Griffith OW, Kalyanaraman B, Baker JE) Free Radic Biol Med 2000 Oct 15;29(8):695-703 PMID: 11053770 10/29/2000 61 Citations

Chromium (VI) increases endothelial cell expression of ICAM-1 and decreases nitric oxide activity. (Pritchard KA Jr, Ackerman A, Kalyanaraman B) J Environ Pathol Toxicol Oncol 2000;19(3):251-60 PMID: 10983891 09/13/2000 31 Citations

Inhibition of adrenal cell aldosterone synthesis by endogenous nitric oxide release. (Hanke CJ, O'Brien T, Pritchard KA Jr, Campbell WB) Hypertension 2000 Jan;35(1 Pt 2):324-8 PMID: 10642319 01/21/2000 32 Citations

Effect of redox-active drugs on superoxide generation from nitric oxide synthases: biological and toxicological implications. (Vásquez-Vivar J, Hogg N, Martásek P, Karoui H, Tordo P, Pritchard KA Jr, Kalyanaraman B) Free Radic Res 1999 Dec;31(6):607-17 PMID: 10630684 01/12/2000 26 Citations

Tetrahydrobiopterin-dependent inhibition of superoxide generation from neuronal nitric oxide synthase. (Vásquez-Vivar J, Hogg N, Martásek P, Karoui H, Pritchard KA Jr, Kalyanaraman B) J Biol Chem 1999 Sep 17;274(38):26736-42 PMID: 10480877 09/10/1999 154 Citations

Adaptation to chronic hypoxia confers tolerance to subsequent myocardial ischemia by increased nitric oxide production. (Baker JE, Holman P, Kalyanaraman B, Griffith OW, Pritchard KA Jr) Ann N Y Acad Sci 1999 Jun 30;874:236-53 PMID: 10415535 07/23/1999 56 Citations

Electron spin resonance spin-trapping detection of superoxide generated by neuronal nitric oxide synthase. (Vásquez-Vivar J, Martásek P, Hogg N, Karoui H, Masters BS, Pritchard KA Jr, Kalyanaraman B) Methods Enzymol 1999;301:169-77 PMID: 9919565 01/27/1999 35 Citations

Adaptation of hearts to chronic hypoxia increases tolerance to subsequent ischemia by increased nitric oxide production. (Baker JE, Holman P, Kalyanaraman B, Pritchard KA Jr) Adv Exp Med Biol 1998;454:203-17 PMID: 9889894 01/16/1999 11 Citations

Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors. (Vásquez-Vivar J, Kalyanaraman B, Martásek P, Hogg N, Masters BS, Karoui H, Tordo P, Pritchard KA Jr) Proc Natl Acad Sci U S A 1998 Aug 04;95(16):9220-5 PMID: 9689061 PMCID: PMC21319 08/05/1998 1115 Citations

Endothelial cells prevent accumulation of lipid hydroperoxides in low-density lipoprotein. (Smalley DM, Hogg N, Kalyanaraman B, Pritchard KA Jr) Arterioscler Thromb Vasc Biol 1997 Dec;17(12):3469-74 PMID: 9437194 01/23/1998 9 Citations

Endothelial nitric oxide synthase-dependent superoxide generation from adriamycin. (Vásquez-Vivar J, Martasek P, Hogg N, Masters BS, Pritchard KA Jr, Kalyanaraman B) Biochemistry 1997 Sep 23;36(38):11293-7 PMID: 9333325 10/23/1997 251 Citations

Suppression of angiotensin-converting enzyme expression and activity by shear stress. (Rieder MJ, Carmona R, Krieger JE, Pritchard KA Jr, Greene AS) Circ Res 1997 Mar;80(3):312-9 PMID: 9048650 03/01/1997 106 Citations

Superoxide anion formation from lucigenin: an electron spin resonance spin-trapping study. (Vásquez-Vivar J, Hogg N, Pritchard KA Jr, Martasek P, Kalyanaraman B) FEBS Lett 1997 Feb 17;403(2):127-30 PMID: 9042951 02/17/1997 182 Citations

Native LDL increases endothelial cell adhesiveness by inducing intercellular adhesion molecule-1. (Smalley DM, Lin JH, Curtis ML, Kobari Y, Stemerman MB, Pritchard KA Jr) Arterioscler Thromb Vasc Biol 1996 Apr;16(4):585-90 PMID: 8624781 04/01/1996

Native low-density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion. (Pritchard KA Jr, Groszek L, Smalley DM, Sessa WC, Wu M, Villalon P, Wolin MS, Stemerman MB) Circ Res 1995 Sep;77(3):510-8 PMID: 7543827 09/01/1995 433 Citations

Oxidized low density lipoprotein increases U937 cell 5-lipoxygenase activity: induction of 5-lipoxygenase activating protein. (Fair A, Pritchard KA Jr) Biochem Biophys Res Commun 1994 Jun 15;201(2):1014-20 PMID: 8002971 06/15/1994 17 Citations

Involvement of nitric oxide and nitrosothiols in relaxation of pulmonary arteries to peroxynitrite. (Wu M, Pritchard KA Jr, Kaminski PM, Fayngersh RP, Hintze TH, Wolin MS) Am J Physiol 1994 May;266(5 Pt 2):H2108-13 PMID: 8203609 05/11/1994 189 Citations

Induction of cyclooxygenase-2 in rat vascular smooth muscle cells in vitro and in vivo. (Pritchard KA Jr, O'Banion MK, Miano JM, Vlasic N, Bhatia UG, Young DA, Stemerman MB) J Biol Chem 1994 Mar 18;269(11):8504-9 PMID: 8132578 03/18/1994 139 Citations

Lipid fluidity modulates platelet aggregation and agglutination in vitro. (Vlasic N, Medow MS, Schwarz SM, Pritchard KA Jr, Stemerman MB) Life Sci 1993;53(13):1053-60 PMID: 8366768 01/01/1993 21 Citations

Production of platelet thromboxane A2 and arterial prostacyclin I2 from hypercholesterolemic rats. (Arnold JH, Pritchard KA Jr, Greco NJ, Panganamala RV) Prostaglandins Leukot Essent Fatty Acids 1992 Jul;46(3):215-7 PMID: 1508954 07/11/1992 4 Citations

Atherogenic levels of low-density lipoprotein increase endocytotic activity in cultured human endothelial cells. (Holland JA, Pritchard KA, Rogers NJ, Stemerman MB) Am J Pathol 1992 Mar;140(3):551-8 PMID: 1546741 PMCID: PMC1886169 03/01/1992 29 Citations

Native low density lipoprotein. Endothelial cell recruitment of mononuclear cells. (Pritchard KA Jr, Tota RR, Lin JH, Danishefsky KJ, Kurilla BA, Holland JA, Stemerman MB) Arterioscler Thromb 1991 Sep-Oct;11(5):1175-81 PMID: 1911704 09/11/1991 48 Citations

Effect of low-density lipoprotein on endothelial cell membrane fluidity and mononuclear cell attachment. (Pritchard KA Jr, Schwarz SM, Medow MS, Stemerman MB) Am J Physiol 1991 Jan;260(1 Pt 1):C43-9 PMID: 1987780 01/11/1991 56 Citations

Atherogenic concentrations of low-density lipoprotein enhance endothelial cell generation of epoxyeicosatrienoic acid products. (Pritchard KA Jr, Wong PY, Stemerman MB) Am J Pathol 1990 Jun;136(6):1383-91 PMID: 2356865 PMCID: PMC1877592 06/01/1990 52 Citations

Bradykinin induces superoxide anion release from human endothelial cells. (Holland JA, Pritchard KA, Pappolla MA, Wolin MS, Rogers NJ, Stemerman MB) J Cell Physiol 1990 Apr;143(1):21-5 PMID: 2156873 04/01/1990 123 Citations

14, 15-Epoxyeicosatrienoic acid promotes endothelial cell dependent adhesion of human monocytic tumor U937 cells. (Pritchard KA Jr, Tota RR, Stemerman MB, Wong PY) Biochem Biophys Res Commun 1990 Feb 28;167(1):137-42 PMID: 2310385 02/28/1990 27 Citations

Effect of lovastatin on serum lipids in patients with nonfamilial primary hypercholesterolemia. (Itskovitz HD, Flamenbaum W, De Gaetano C, Pritchard KA Jr, Stemerman MB) Clin Ther 1989 Nov-Dec;11(6):862-72 PMID: 2611825 11/01/1989 4 Citations

Agonist-dependent generation of lipoxins from rat basophilic leukemia cell (RBL-1). (Ng CF, Lam BK, Pritchard KA Jr, Stemerman MB, Hejny P, Wong PY) Biochim Biophys Acta 1989 Aug 22;1004(3):332-6 PMID: 2503031 08/22/1989 5 Citations

Low density lipoprotein-mediated endothelial cell perturbation: effects on endothelial cell eicosanoid metabolism. (Miano JM, Holland JA, Pritchard KA Jr, Rogers NJ, Stemerman MB) Adv Prostaglandin Thromboxane Leukot Res 1989;19:248-54 PMID: 2526478 01/01/1989

Formation of lipoxins by rat basophilic leukemia cells. (Ng CF, Lam BK, Pritchard KA Jr, Stemerman MB, Hejny P, Wong PY) Adv Prostaglandin Thromboxane Leukot Res 1989;19:128-31 PMID: 2526456 01/01/1989 3 Citations

Low-density lipoprotein preparation by combined diafiltration and ultracentrifugation. (Pritchard KA Jr, Holland JA, Rogers NJ, Crean CC, Britton TE, Onigman P, Stemerman MB) Anal Biochem 1988 Oct;174(1):121-7 PMID: 3218726 10/01/1988 5 Citations

Perturbation of cultured human endothelial cells by atherogenic levels of low density lipoprotein. (Holland JA, Pritchard KA, Rogers NJ, Stemerman MB) Am J Pathol 1988 Sep;132(3):474-8 PMID: 3046368 PMCID: PMC1880753 09/01/1988 54 Citations

Endothelial cell perturbation and low-density lipoprotein. Quantitative autoradiography. (Morrel EM, Holland JA, Pritchard KA, Colton CK, Stemerman MB) Ann N Y Acad Sci 1987;516:412-7 PMID: 3439738 01/01/1987 9 Citations

Triglyceride-lowering effect of dietary vitamin E in streptozocin-induced diabetic rats. Increased lipoprotein lipase activity in livers of diabetic rats fed high dietary vitamin E. (Pritchard KA Jr, Patel ST, Karpen CW, Newman HA, Panganamala RV) Diabetes 1986 Mar;35(3):278-81 PMID: 3512338 03/01/1986

Effect of dietary vitamin E on the production of platelet 12-hydroxyeicosatetraenoic acid (12-HETE). (Pritchard KA, Greco NJ, Panganamala RV) Thromb Haemost 1986 Feb 28;55(1):6-7 PMID: 3705009 02/28/1986 10 Citations

Evaluation of the Coomassie Brilliant Blue G-250 method for urinary protein. (Lott JA, Stephan VA, Pritchard KA Jr) Clin Chem 1983 Nov;29(11):1946-50 PMID: 6354513 11/01/1983 89 Citations

Influence of dietary vitamin E on platelet thromboxane A2 and vascular prostacyclin I2 in rabbit. (Pritchard KA Jr, Karpen CW, Merola AJ, Panganamala RV) Prostaglandins Leukot Med 1982 Oct;9(4):373-8 PMID: 6757965 10/01/1982 19 Citations

Alterations of the prostacyclin-thromboxane ratio in streptozotocin induced diabetic rats. (Karpen CW, Pritchard KA Jr, Merola AJ, Panganamala RV) Prostaglandins Leukot Med 1982 Feb;8(2):93-103 PMID: 6804992 02/01/1982 48 Citations

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Profiles for MCW, MU, MSOE, UWM, BCW, CHW, Froedtert, and VA Faculty

Kirkwood A. Pritchard PhD

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