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1 | Rational Design and Development of Selective BRD7 Bromodomain Inhibitors and Their Activity in Prostate Cancer. (Ordonez-Rubiano SC, Maschinot CA, Wang S, Sood S, Baracaldo-Lancheros LF, Strohmier BP, McQuade AJ, Smith BC, Dykhuizen EC) J Med Chem 2023 Aug 24;66(16):11250-11270 6 Citations |
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1 | Distinct gene expression profiles underlie morphological and etiological differences in pediatric cataracts. (Shanbagh S, Matalia J, Kannan R, Shetty R, Panmand P, Muthu SO, Chaurasia SS, Deshpande V, Bhattacharya SS, Gopalakrishnan AV, Ghosh A) Indian J Ophthalmol 2023 May;71(5):2143-2151 2 Citations |
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1 | Trajectory reconstruction identifies dysregulation of perinatal maturation programs in pluripotent stem cell-derived cardiomyocytes. (Kannan S, Miyamoto M, Zhu R, Lynott M, Guo J, Chen EZ, Colas AR, Lin BL, Kwon C) Cell Rep 2023 Apr 25;42(4):112330 4 Citations |
1 | ATP-Dependent Chromatin Remodellers in Inner Ear Development. (Chohra I, Chung K, Giri S, Malgrange B) Cells 2023 Feb 07;12(4) 4 Citations |
1 | The small GTPase regulatory protein Rac1 drives podocyte injury independent of cationic channel protein TRPC5. (Polat OK, Isaeva E, Sudhini YR, Knott B, Zhu K, Noben M, Suresh Kumar V, Endlich N, Mangos S, Reddy TV, Samelko B, Wei C, Altintas MM, Dryer SE, Sever S, Staruschenko A, Reiser J) Kidney Int 2023 Jun;103(6):1056-1062 10 Citations |
1 | Diminished motor neuron activity driven by abnormal astrocytic EAAT1 glutamate transporter activity in spinal muscular atrophy is not fully restored after lentiviral SMN delivery. (Welby E, Ebert AD) Glia 2023 May;71(5):1311-1332 5 Citations |
1 | Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma. (Ferguson LP, Gatchalian J, McDermott ML, Nakamura M, Chambers K, Rajbhandari N, Lytle NK, Rosenthal SB, Hamilton M, Albini S, Wartenberg M, Zlobec I, Galván JA, Karamitopoulou E, Vavinskaya V, Wascher A, Lowy AM, Schürch CM, Puri PL, Bruneau BG, Hargreaves DC, Reya T) Nat Commun 2023 Jan 18;14(1):292 9 Citations |
3 | TCEAL1 loss-of-function results in an X-linked dominant neurodevelopmental syndrome and drives the neurological disease trait in Xq22.2 deletions. (Hijazi H, Reis LM, Pehlivan D, Bernstein JA, Muriello M, Syverson E, Bonner D, Estiar MA, Gan-Or Z, Rouleau GA, Lyulcheva E, Greenhalgh L, Tessarech M, Colin E, Guichet A, Bonneau D, van Jaarsveld RH, Lachmeijer AMA, Ruaud L, Levy J, Tabet AC, Ploski R, Rydzanicz M, Kępczyński Ł, Połatyńska K, Li Y, Fatih JM, Marafi D, Rosenfeld JA, Coban-Akdemir Z, Bi W, Gibbs RA, Hobson GM, Hunter JV, Carvalho CMB, Posey JE, Semina EV, Lupski JR) Am J Hum Genet 2022 Dec 01;109(12):2270-2282 9 Citations |
3 | Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening. (Shishodia S, Nuñez R, Strohmier BP, Bursch KL, Goetz CJ, Olp MD, Jensen DR, Fenske TG, Ordonez-Rubiano SC, Blau ME, Roach MK, Peterson FC, Volkman BF, Dykhuizen EC, Smith BC) J Med Chem 2022 Oct 27;65(20):13714-13735 14 Citations |
4 | N-terminal BET bromodomain inhibitors disrupt a BRD4-p65 interaction and reduce inducible nitric oxide synthase transcription in pancreatic β-cells. (Nord JA, Wynia-Smith SL, Gehant AL, Jones Lipinski RA, Naatz A, Rioja I, Prinjha RK, Corbett JA, Smith BC) Front Endocrinol (Lausanne) 2022;13:923925 7 Citations |
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2 | Combinatorial genetics reveals the Dock1-Rac2 axis as a potential target for the treatment of NPM1;Cohesin mutated AML. (Meyer AE, Stelloh C, Pulakanti K, Burns R, Fisher JB, Heimbruch KE, Tarima S, Furumo Q, Brennan J, Zheng Y, Viny AD, Vassiliou GS, Rao S) Leukemia 2022 Aug;36(8):2032-2041 6 Citations |
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1 | Post-GWAS functional analysis identifies CUX1 as a regulator of p16INK4a and cellular senescence. (Jiang D, Sun W, Wu T, Zou M, Vasamsetti SB, Zhang X, Zhao Y, Phillippi JA, Sawalha AH, Tavakoli S, Dutta P, Florentin J, Chan SY, Tollison TS, Di Wu, Cui J, Huntress I, Peng X, Finkel T, Li G) Nat Aging 2022 Feb;2(2):140-154 |
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1 | Evolutionary Conservation of Structural and Functional Coupling between the BRM AT-Hook and Bromodomain. (Lupo BE, Chu P, Harms MJ, Morrison EA, Musselman CA) J Mol Biol 2021 Jul 09;433(14):166845 5 Citations |
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1 | The rax homeobox gene is mutated in the eyeless axolotl, Ambystoma mexicanum. (Davis ES, Voss G, Miesfeld JB, Zarate-Sanchez J, Voss SR, Glaser T) Dev Dyn 2021 Jun;250(6):807-821 4 Citations |
1 | The Atoh7 remote enhancer provides transcriptional robustness during retinal ganglion cell development. (Miesfeld JB, Ghiasvand NM, Marsh-Armstrong B, Marsh-Armstrong N, Miller EB, Zhang P, Manna SK, Zawadzki RJ, Brown NL, Glaser T) Proc Natl Acad Sci U S A 2020 Sep 01;117(35):21690-21700 28 Citations |
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1 | Interacting hepatic PAI-1/tPA gene regulatory pathways influence impaired fibrinolysis severity in obesity. (Zheng Z, Nakamura K, Gershbaum S, Wang X, Thomas S, Bessler M, Schrope B, Krikhely A, Liu RM, Ozcan L, López JA, Tabas I) J Clin Invest 2020 Aug 03;130(8):4348-4359 31 Citations |
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2 | Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites. (Olp MD, Sprague DJ, Goetz CJ, Kathman SG, Wynia-Smith SL, Shishodia S, Summers SB, Xu Z, Statsyuk AV, Smith BC) ACS Chem Biol 2020 Apr 17;15(4):1036-1049 37 Citations |
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1 | Loss of PTEN Accelerates NKX3.1 Degradation to Promote Prostate Cancer Progression. (Bowen C, Ostrowski MC, Leone G, Gelmann EP) Cancer Res 2019 Aug 15;79(16):4124-4134 27 Citations |
1 | A case of Coffin-Siris syndrome with severe congenital heart disease and a novel SMARCA4 variant. (Dsouza NR, Zimmermann MT, Geddes GC) Cold Spring Harb Mol Case Stud 2019 Jun;5(3) 11 Citations |
2 | The Roles of Hippo Signaling Transducers Yap and Taz in Chromatin Remodeling. (Hillmer RE, Link BA) Cells 2019 May 24;8(5) 46 Citations |
1 | Global Transcriptomic Profile Analysis of Genes Involved in Lignin Biosynthesis and Accumulation Induced by Boron Deficiency in Poplar Roots. (Su WL, Liu N, Mei L, Luo J, Zhu YJ, Liang Z) Biomolecules 2019 Apr 19;9(4) 22 Citations |
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1 | De novo variants in congenital diaphragmatic hernia identify MYRF as a new syndrome and reveal genetic overlaps with other developmental disorders. (Qi H, Yu L, Zhou X, Wynn J, Zhao H, Guo Y, Zhu N, Kitaygorodsky A, Hernan R, Aspelund G, Lim FY, Crombleholme T, Cusick R, Azarow K, Danko ME, Chung D, Warner BW, Mychaliska GB, Potoka D, Wagner AJ, ElFiky M, Wilson JM, Nickerson D, Bamshad M, High FA, Longoni M, Donahoe PK, Chung WK, Shen Y) PLoS Genet 2018 Dec;14(12):e1007822 79 Citations |
1 | An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1. (Zheng Z, Nayak L, Wang W, Yurdagul A Jr, Wang X, Cai B, Lapping S, Ozcan L, Ramakrishnan R, Pestell RG, Jain MK, Tabas I) Blood 2019 Feb 14;133(7):743-753 24 Citations |
2 | Suppressor mutations reveal an NtrC-like response regulator, NmpR, for modulation of Type-IV Pili-dependent motility in Myxococcus xanthus. (Bretl DJ, Ladd KM, Atkinson SN, Müller S, Kirby JR) PLoS Genet 2018 Oct;14(10):e1007714 6 Citations |
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1 | RitR is an archetype for a novel family of redox sensors in the streptococci that has evolved from two-component response regulators and is required for pneumococcal colonization. (Glanville DG, Han L, Maule AF, Woodacre A, Thanki D, Abdullah IT, Morrissey JA, Clarke TB, Yesilkaya H, Silvaggi NR, Ulijasz AT) PLoS Pathog 2018 May;14(5):e1007052 18 Citations |
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1 | Mutations of conserved non-coding elements of PITX2 in patients with ocular dysgenesis and developmental glaucoma. (Protas ME, Weh E, Footz T, Kasberger J, Baraban SC, Levin AV, Katz LJ, Ritch R, Walter MA, Semina EV, Gould DB) Hum Mol Genet 2017 Sep 15;26(18):3630-3638 30 Citations |
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1 | A model for the molecular underpinnings of tooth defects in Axenfeld-Rieger syndrome. (Li X, Venugopalan SR, Cao H, Pinho FO, Paine ML, Snead ML, Semina EV, Amendt BA) Hum Mol Genet 2014 Jan 01;23(1):194-208 23 Citations |
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1 | odd-skipped related 2 is required for fin chondrogenesis in zebrafish. (Lam PY, Kamei CN, Mangos S, Mudumana S, Liu Y, Drummond IA) Dev Dyn 2013 Nov;242(11):1284-92 11 Citations |
1 | Tcf19 is a novel islet factor necessary for proliferation and survival in the INS-1 β-cell line. (Krautkramer KA, Linnemann AK, Fontaine DA, Whillock AL, Harris TW, Schleis GJ, Truchan NA, Marty-Santos L, Lavine JA, Cleaver O, Kimple ME, Davis DB) Am J Physiol Endocrinol Metab 2013 Sep 01;305(5):E600-10 29 Citations |
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1 | MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis. (International Multiple Sclerosis Genetics Consortium, Lill CM, Schjeide BM, Graetz C, Ban M, Alcina A, Ortiz MA, Pérez J, Damotte V, Booth D, Lopez de Lapuente A, Broer L, Schilling M, Akkad DA, Aktas O, Alloza I, Antigüedad A, Arroyo R, Blaschke P, Buttmann M, Chan A, Compston A, Cournu-Rebeix I, Dörner T, Epplen JT, Fernández Ó, Gerdes LA, Guillot-Noël L, Hartung HP, Hoffjan S, Izquierdo G, Kemppinen A, Kroner A, Kubisch C, Kümpfel T, Li SC, Lindenberger U, Lohse P, Lubetzki C, Luessi F, Malhotra S, Mescheriakova J, Montalban X, Papeix C, Paredes LF, Rieckmann P, Steinhagen-Thiessen E, Winkelmann A, Zettl UK, Hintzen R, Vandenbroeck K, Stewart G, Fontaine B, Comabella M, Urcelay E, Matesanz F, Sawcer S, Bertram L, Zipp F) Brain 2013 Jun;136(Pt 6):1778-82 59 Citations |
1 | Genome-wide expression analysis and EMX2 gene expression in embryonic myoblasts committed to diverse skeletal muscle fiber type fates. (Weimer K, Theobald J, Campbell KS, Esser KA, DiMario JX) Dev Dyn 2013 Aug;242(8):1001-20 6 Citations |
1 | A comprehensive analysis of adiponectin QTLs using SNP association, SNP cis-effects on peripheral blood gene expression and gene expression correlation identified novel metabolic syndrome (MetS) genes with potential role in carcinogenesis and systemic inflammation. (Zhang Y, Kent JW Jr, Olivier M, Ali O, Cerjak D, Broeckel U, Abdou RM, Dyer TD, Comuzzie A, Curran JE, Carless MA, Rainwater DL, Göring HH, Blangero J, Kissebah AH) BMC Med Genomics 2013 Apr 29;6:14 25 Citations |
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1 | Snai1 is important for avian epicardial cell transformation and motility. (Tao G, Miller LJ, Lincoln J) Dev Dyn 2013 Jun;242(6):699-708 12 Citations |
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1 | Identification of nephropathy candidate genes by comparing sclerosis-prone and sclerosis-resistant mouse strain kidney transcriptomes. (El-Meanawy A, Schelling JR, Iyengar SK, Hayden P, Barathan S, Goddard K, Pozuelo F, Elashi E, Nair V, Kretzler M, Sedor JR) BMC Nephrol 2012 Jul 19;13:61 7 Citations |
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1 | Integration of Hi-C and ChIP-seq data reveals distinct types of chromatin linkages. (Lan X, Witt H, Katsumura K, Ye Z, Wang Q, Bresnick EH, Farnham PJ, Jin VX) Nucleic Acids Res 2012 Sep;40(16):7690-704 84 Citations |
1 | Mechanistic role for a novel glucocorticoid-KLF11 (TIEG2) protein pathway in stress-induced monoamine oxidase A expression. (Grunewald M, Johnson S, Lu D, Wang Z, Lomberk G, Albert PR, Stockmeier CA, Meyer JH, Urrutia R, Miczek KA, Austin MC, Wang J, Paul IA, Woolverton WL, Seo S, Sittman DB, Ou XM) J Biol Chem 2012 Jul 13;287(29):24195-206 81 Citations |
1 | Effect of exercise on mouse liver and brain bioenergetic infrastructures. (E L, Lu J, Burns JM, Swerdlow RH) Exp Physiol 2013 Jan;98(1):207-19 37 Citations |
3 | PITX2 and FOXC1 spectrum of mutations in ocular syndromes. (Reis LM, Tyler RC, Volkmann Kloss BA, Schilter KF, Levin AV, Lowry RB, Zwijnenburg PJ, Stroh E, Broeckel U, Murray JC, Semina EV) Eur J Hum Genet 2012 Dec;20(12):1224-33 120 Citations |
1 | Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer. (Dong C, Wu Y, Wang Y, Wang C, Kang T, Rychahou PG, Chi YI, Evers BM, Zhou BP) Oncogene 2013 Mar 14;32(11):1351-62 180 Citations |
1 | Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse. (Dillon LM, Williams SL, Hida A, Peacock JD, Prolla TA, Lincoln J, Moraes CT) Hum Mol Genet 2012 May 15;21(10):2288-97 80 Citations |
1 | Genetic variation in TRPS1 may regulate hip geometry as well as bone mineral density. (Ackert-Bicknell CL, Demissie S, Tsaih SW, Beamer WG, Cupples LA, Paigen BJ, Hsu YH, Kiel DP, Karasik D) Bone 2012 May;50(5):1188-95 10 Citations |
1 | pitx2 Deficiency results in abnormal ocular and craniofacial development in zebrafish. (Liu Y, Semina EV) PLoS One 2012;7(1):e30896 31 Citations |
1 | Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR. (Gabai VL, Meng L, Kim G, Mills TA, Benjamin IJ, Sherman MY) Mol Cell Biol 2012 Mar;32(5):929-40 87 Citations |
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1 | Genomic analysis using high-density single nucleotide polymorphism-based oligonucleotide arrays and multiplex ligation-dependent probe amplification provides a comprehensive analysis of INI1/SMARCB1 in malignant rhabdoid tumors. (Jackson EM, Sievert AJ, Gai X, Hakonarson H, Judkins AR, Tooke L, Perin JC, Xie H, Shaikh TH, Biegel JA) Clin Cancer Res 2009 Mar 15;15(6):1923-30 172 Citations |
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1 | Anopheles gambiae APL1 is a family of variable LRR proteins required for Rel1-mediated protection from the malaria parasite, Plasmodium berghei. (Riehle MM, Xu J, Lazzaro BP, Rottschaefer SM, Coulibaly B, Sacko M, Niare O, Morlais I, Traore SF, Vernick KD) PLoS One 2008;3(11):e3672 64 Citations |
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1 | Induction of heat shock proteins by heregulin beta1 leads to protection from apoptosis and anchorage-independent growth. (Khaleque MA, Bharti A, Sawyer D, Gong J, Benjamin IJ, Stevenson MA, Calderwood SK) Oncogene 2005 Sep 29;24(43):6564-73 91 Citations |
1 | Heat shock factor 1-deficient mice exhibit decreased recovery of hearing following noise overstimulation. (Fairfield DA, Lomax MI, Dootz GA, Chen S, Galecki AT, Benjamin IJ, Dolan DF, Altschuler RA) J Neurosci Res 2005 Aug 15;81(4):589-96 36 Citations |
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1 | Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells. (Calmels B, Ferguson C, Laukkanen MO, Adler R, Faulhaber M, Kim HJ, Sellers S, Hematti P, Schmidt M, von Kalle C, Akagi K, Donahue RE, Dunbar CE) Blood 2005 Oct 01;106(7):2530-3 136 Citations |
1 | Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets. (Niu Z, Yu W, Zhang SX, Barron M, Belaguli NS, Schneider MD, Parmacek M, Nordheim A, Schwartz RJ) J Biol Chem 2005 Sep 16;280(37):32531-8 103 Citations |
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1 | Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex. (Nishioka N, Nagano S, Nakayama R, Kiyonari H, Ijiri T, Taniguchi K, Shawlot W, Hayashizaki Y, Westphal H, Behringer RR, Matsuda Y, Sakoda S, Kondoh H, Sasaki H) Development 2005 Jun;132(11):2535-46 60 Citations |
1 | Distinct capacities of individual E2Fs to induce cell cycle re-entry in postmitotic lens fiber cells of transgenic mice. (Chen Q, Liang D, Yang T, Leone G, Overbeek PA) Dev Neurosci 2004;26(5-6):435-45 19 Citations |
1 | Protein kinase C phosphorylation modulates N- and C-terminal regulatory activities of the PITX2 homeodomain protein. (Espinoza HM, Ganga M, Vadlamudi U, Martin DM, Brooks BP, Semina EV, Murray JC, Amendt BA) Biochemistry 2005 Mar 15;44(10):3942-54 26 Citations |
1 | HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. (Gray MJ, Zhang J, Ellis LM, Semenza GL, Evans DB, Watowich SS, Gallick GE) Oncogene 2005 Apr 28;24(19):3110-20 346 Citations |
1 | Homeodomain revisited: a lesson from disease-causing mutations. (Chi YI) Hum Genet 2005 May;116(6):433-44 61 Citations |
1 | Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation. (Maiti B, Li J, de Bruin A, Gordon F, Timmers C, Opavsky R, Patil K, Tuttle J, Cleghorn W, Leone G) J Biol Chem 2005 May 06;280(18):18211-20 162 Citations |
1 | Mouse HSF1 disruption perturbs redox state and increases mitochondrial oxidative stress in kidney. (Yan LJ, Rajasekaran NS, Sathyanarayanan S, Benjamin IJ) Antioxid Redox Signal 2005;7(3-4):465-71 48 Citations |
1 | Overexpression of tropomysin-related kinase B in metastatic human pancreatic cancer cells. (Sclabas GM, Fujioka S, Schmidt C, Li Z, Frederick WA, Yang W, Yokoi K, Evans DB, Abbruzzese JL, Hess KR, Zhang W, Fidler IJ, Chiao PJ) Clin Cancer Res 2005 Jan 15;11(2 Pt 1):440-9 122 Citations |
1 | Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages. (Iavarone A, King ER, Dai XM, Leone G, Stanley ER, Lasorella A) Nature 2004 Dec 23;432(7020):1040-5 124 Citations |
1 | IFI16 is an essential mediator of growth inhibition, but not differentiation, induced by the leukemia inhibitory factor/JAK/STAT pathway in medullary thyroid carcinoma cells. (Kim EJ, Park JI, Nelkin BD) J Biol Chem 2005 Feb 11;280(6):4913-20 49 Citations |
2 | Using zebrafish to study the complex genetics of glaucoma. (McMahon C, Semina EV, Link BA) Comp Biochem Physiol C Toxicol Pharmacol 2004 Jul;138(3):343-50 53 Citations |
1 | Mutations in PITX2 may contribute to cases of omphalocele and VATER-like syndromes. (Katz LA, Schultz RE, Semina EV, Torfs CP, Krahn KN, Murray JC) Am J Med Genet A 2004 Oct 15;130A(3):277-83 22 Citations |
1 | Treatment with {alpha}-phenyl-N-tert-butylnitrone, a free radical-trapping agent, abrogates inflammatory cytokine gene expression during alloimmune activation in rat cardiac allografts. (Pieper GM, Nilakantan V, Zhou X, Khanna AK, Johnson CP, Roza AM, Adams MB, Hilton G, Felix CC) J Pharmacol Exp Ther 2005 Feb;312(2):774-9 7 Citations |
1 | Statistical modeling for selecting housekeeper genes. (Szabo A, Perou CM, Karaca M, Perreard L, Palais R, Quackenbush JF, Bernard PS) Genome Biol 2004;5(8):R59 163 Citations |
1 | Aberrant regulation of survivin by the RB/E2F family of proteins. (Jiang Y, Saavedra HI, Holloway MP, Leone G, Altura RA) J Biol Chem 2004 Sep 24;279(39):40511-20 151 Citations |
1 | A novel mutation in the PITX2 gene in a family with Axenfeld-Rieger syndrome. (Brooks BP, Moroi SE, Downs CA, Wiltse S, Othman MI, Semina EV, Richards JE) Ophthalmic Genet 2004 Mar;25(1):57-62 26 Citations |
1 | Characterization of Lef-1 promoter segments that facilitate inductive developmental expression in skin. (Liu X, Driskell RR, Luo M, Abbott D, Filali M, Cheng N, Sigmund CD, Engelhardt JF) J Invest Dermatol 2004 Aug;123(2):264-74 29 Citations |
1 | Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences. (Lamba JK, Lamba V, Yasuda K, Lin YS, Assem M, Thompson E, Strom S, Schuetz E) J Pharmacol Exp Ther 2004 Nov;311(2):811-21 92 Citations |
1 | Wnt-responsive element controls Lef-1 promoter expression during submucosal gland morphogenesis. (Driskell RR, Liu X, Luo M, Filali M, Zhou W, Abbott D, Cheng N, Moothart C, Sigmund CD, Engelhardt JF) Am J Physiol Lung Cell Mol Physiol 2004 Oct;287(4):L752-63 32 Citations |
1 | Glucose regulation of insulin gene expression requires the recruitment of p300 by the beta-cell-specific transcription factor Pdx-1. (Mosley AL, Corbett JA, Ozcan S) Mol Endocrinol 2004 Sep;18(9):2279-90 102 Citations |
1 | Integrase-specific enhancement and suppression of retroviral DNA integration by compacted chromatin structure in vitro. (Taganov KD, Cuesta I, Daniel R, Cirillo LA, Katz RA, Zaret KS, Skalka AM) J Virol 2004 Jun;78(11):5848-55 50 Citations |
1 | Gene expression profiling of potential PPARgamma target genes in mouse aorta. (Keen HL, Ryan MJ, Beyer A, Mathur S, Scheetz TE, Gackle BD, Faraci FM, Casavant TL, Sigmund CD) Physiol Genomics 2004 Jun 17;18(1):33-42 44 Citations |
1 | Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. (Assem M, Schuetz EG, Leggas M, Sun D, Yasuda K, Reid G, Zelcer N, Adachi M, Strom S, Evans RM, Moore DD, Borst P, Schuetz JD) J Biol Chem 2004 May 21;279(21):22250-7 218 Citations |
1 | Structural basis for HNF-4alpha activation by ligand and coactivator binding. (Duda K, Chi YI, Shoelson SE) J Biol Chem 2004 May 28;279(22):23311-6 69 Citations |
1 | Preparation of defined mononucleosomes, dinucleosomes, and nucleosome arrays in vitro and analysis of transcription factor binding. (Cirillo LA, Zaret KS) Methods Enzymol 2004;375:131-58 8 Citations |
1 | Transforming growth factor-beta1 inhibition of vascular smooth muscle cell activation is mediated via Smad3. (Feinberg MW, Watanabe M, Lebedeva MA, Depina AS, Hanai J, Mammoto T, Frederick JP, Wang XF, Sukhatme VP, Jain MK) J Biol Chem 2004 Apr 16;279(16):16388-93 63 Citations |
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1 | PPAR(gamma) agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice. (Ryan MJ, Didion SP, Mathur S, Faraci FM, Sigmund CD) Hypertension 2004 Mar;43(3):661-6 176 Citations |
1 | CD36 mediates the phagocytosis of Plasmodium falciparum-infected erythrocytes by rodent macrophages. (Patel SN, Serghides L, Smith TG, Febbraio M, Silverstein RL, Kurtz TW, Pravenec M, Kain KC) J Infect Dis 2004 Jan 15;189(2):204-13 111 Citations |
1 | Evaluation of histogenesis of B-lymphocytes in pediatric EBV-related post-transplant lymphoproliferative disorders. (Abed N, Casper JT, Camitta BM, Margolis D, Trost B, Orentas R, Chang CC) Bone Marrow Transplant 2004 Feb;33(3):321-7 15 Citations |
1 | Reactive oxygen species and molecular regulation of renal oxygenation. (Zou AP, Cowley AW Jr) Acta Physiol Scand 2003 Nov;179(3):233-41 72 Citations |
1 | PPARgamma is not required for the inhibitory actions of PGJ2 on cytokine signaling in pancreatic beta-cells. (Weber SM, Scarim AL, Corbett JA) Am J Physiol Endocrinol Metab 2004 Mar;286(3):E329-36 32 Citations |
1 | Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF. (Nanba D, Mammoto A, Hashimoto K, Higashiyama S) J Cell Biol 2003 Nov 10;163(3):489-502 140 Citations |
1 | RNA-protein interactions promote asymmetric sorting of the ASH1 mRNA ribonucleoprotein complex. (Gonsalvez GB, Lehmann KA, Ho DK, Stanitsa ES, Williamson JR, Long RM) RNA 2003 Nov;9(11):1383-99 34 Citations |
1 | Use of Hsf1(-/-) mice reveals an essential role for HSF1 to protect lung against cadmium-induced injury. (Wirth D, Christians E, Li X, Benjamin IJ, Gustin P) Toxicol Appl Pharmacol 2003 Oct 01;192(1):12-20 25 Citations |
1 | Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer. (Stoeltzing O, Liu W, Reinmuth N, Fan F, Parikh AA, Bucana CD, Evans DB, Semenza GL, Ellis LM) Am J Pathol 2003 Sep;163(3):1001-11 148 Citations |
1 | Selective loss of dopaminergic neurons in the substantia nigra of Pitx3-deficient aphakia mice. (Hwang DY, Ardayfio P, Kang UJ, Semina EV, Kim KS) Brain Res Mol Brain Res 2003 Jun 10;114(2):123-31 219 Citations |
2 | Genetic variability at the human FMO1 locus: significance of a basal promoter yin yang 1 element polymorphism (FMO1*6). (Hines RN, Luo Z, Hopp KA, Cabacungan ET, Koukouritaki SB, McCarver DG) J Pharmacol Exp Ther 2003 Sep;306(3):1210-8 39 Citations |
1 | Localized recruitment of a chromatin-remodeling activity by an activator in vivo drives transcriptional elongation. (Corey LL, Weirich CS, Benjamin IJ, Kingston RE) Genes Dev 2003 Jun 01;17(11):1392-401 118 Citations |
1 | Utilizing NMR to study the structure of growth-inhibitory proteins. (Marassi F) Methods Mol Biol 2003;223:3-15 |
1 | Heat shock factor 1-independent activation of dendritic cells by heat shock: implication for the uncoupling of heat-mediated immunoregulation from the heat shock response. (Zheng H, Benjamin IJ, Basu S, Li Z) Eur J Immunol 2003 Jun;33(6):1754-62 29 Citations |
1 | Left and right contributions to the Xenopus heart: implications for asymmetric morphogenesis. (Gormley JP, Nascone-Yoder NM) Dev Genes Evol 2003 Aug;213(8):390-8 23 Citations |
1 | AP-4F, antennapedia peptide linked to an amphipathic alpha helical peptide, increases the efficiency of Lipofectamine-mediated gene transfection in endothelial cells. (Ou J, Geiger T, Ou Z, Ackerman AW, Oldham KT, Pritchard KA Jr) Biochem Biophys Res Commun 2003 Jun 06;305(3):605-10 15 Citations |
1 | Inactivation of E2F3 results in centrosome amplification. (Saavedra HI, Maiti B, Timmers C, Altura R, Tokuyama Y, Fukasawa K, Leone G) Cancer Cell 2003 Apr;3(4):333-46 64 Citations |
1 | Temporal-spatial characterization of chicken clock genes: circadian expression in retina, pineal gland, and peripheral tissues. (Chong NW, Chaurasia SS, Haque R, Klein DC, Iuvone PM) J Neurochem 2003 May;85(4):851-60 66 Citations |
1 | Identification and functional characterization of a novel mutation of hepatocyte nuclear factor-1alpha gene in a Korean family with MODY3. (Kim KA, Kang K, Chi YI, Chang I, Lee MK, Kim KW, Shoelson SE, Lee MS) Diabetologia 2003 May;46(5):721-7 23 Citations |
2 | Mechanisms and implications of platelet discoid shape. (Italiano JE Jr, Bergmeier W, Tiwari S, Falet H, Hartwig JH, Hoffmeister KM, André P, Wagner DD, Shivdasani RA) Blood 2003 Jun 15;101(12):4789-96 141 Citations |
2 | Expression of p53, c-Myc, or Bcl-6 suggests a poor prognosis in primary central nervous system diffuse large B-cell lymphoma among immunocompetent individuals. (Chang CC, Kampalath B, Schultz C, Bunyi-Teopengco E, Logan B, Eshoa C, Dincer AP, Perkins SL) Arch Pathol Lab Med 2003 Feb;127(2):208-12 72 Citations |
1 | Inhibition of IFN-gamma -induced STAT1 activation by 15- deoxy-Delta 12,14-prostaglandin J2. (Weber SM, Scarim AL, Corbett JA) Am J Physiol Endocrinol Metab 2003 May;284(5):E883-91 17 Citations |
1 | CD36-mediated nonopsonic phagocytosis of erythrocytes infected with stage I and IIA gametocytes of Plasmodium falciparum. (Smith TG, Serghides L, Patel SN, Febbraio M, Silverstein RL, Kain KC) Infect Immun 2003 Jan;71(1):393-400 58 Citations |
1 | Diabetes mutations delineate an atypical POU domain in HNF-1alpha. (Chi YI, Frantz JD, Oh BC, Hansen L, Dhe-Paganon S, Shoelson SE) Mol Cell 2002 Nov;10(5):1129-37 89 Citations |
1 | Expression of MUM1/IRF4 correlates with clinical outcome in patients with B-cell chronic lymphocytic leukemia. (Chang CC, Lorek J, Sabath DE, Li Y, Chitambar CR, Logan B, Kampalath B, Cleveland RP) Blood 2002 Dec 15;100(13):4671-5 54 Citations |
1 | Heat shock transcription factor 2 is not essential for embryonic development, fertility, or adult cognitive and psychomotor function in mice. (McMillan DR, Christians E, Forster M, Xiao X, Connell P, Plumier JC, Zuo X, Richardson J, Morgan S, Benjamin IJ) Mol Cell Biol 2002 Nov;22(22):8005-14 66 Citations |
1 | Adrenocortical responses to ACTH in neonatal rats: effect of hypoxia from birth on corticosterone, StAR, and PBR. (Raff H, Hong JJ, Oaks MK, Widmaier EP) Am J Physiol Regul Integr Comp Physiol 2003 Jan;284(1):R78-85 45 Citations |
1 | Mouse heat shock transcription factor 1 deficiency alters cardiac redox homeostasis and increases mitochondrial oxidative damage. (Yan LJ, Christians ES, Liu L, Xiao X, Sohal RS, Benjamin IJ) EMBO J 2002 Oct 01;21(19):5164-72 205 Citations |
1 | Age-related decreases in Nurr1 immunoreactivity in the human substantia nigra. (Chu Y, Kompoliti K, Cochran EJ, Mufson EJ, Kordower JH) J Comp Neurol 2002 Aug 26;450(3):203-14 176 Citations |
1 | Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand. (Dhe-Paganon S, Duda K, Iwamoto M, Chi YI, Shoelson SE) J Biol Chem 2002 Oct 11;277(41):37973-6 248 Citations |
1 | Metabolic adaptation of the fetal and postnatal ovine heart: regulatory role of hypoxia-inducible factors and nuclear respiratory factor-1. (Nau PN, Van Natta T, Ralphe JC, Teneyck CJ, Bedell KA, Caldarone CA, Segar JL, Scholz TD) Pediatr Res 2002 Aug;52(2):269-78 46 Citations |
1 | Exclusion of PITX2 mutations as a major cause of CHARGE association. (Martin DM, Probst FJ, Fox SE, Schimmenti LA, Semina EV, Hefner MA, Belmont JW, Camper SA) Am J Med Genet 2002 Jul 22;111(1):27-30 19 Citations |
3 | Activation of protein kinases in chronically hypoxic infant human and rabbit hearts: role in cardioprotection. (Rafiee P, Shi Y, Kong X, Pritchard KA Jr, Tweddell JS, Litwin SB, Mussatto K, Jaquiss RD, Su J, Baker JE) Circulation 2002 Jul 09;106(2):239-45 82 Citations |
1 | Specificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of Rb. (Saavedra HI, Wu L, de Bruin A, Timmers C, Rosol TJ, Weinstein M, Robinson ML, Leone G) Cell Growth Differ 2002 May;13(5):215-25 94 Citations |
1 | Exercise, estrogen, and ischemic cardioprotection by heat shock protein 70. (Benjamin IJ, Christians E) Circ Res 2002 May 03;90(8):833-5 19 Citations |
1 | Spi-B can functionally replace PU.1 in myeloid but not lymphoid development. (Dahl R, Ramirez-Bergeron DL, Rao S, Simon MC) EMBO J 2002 May 01;21(9):2220-30 39 Citations |
1 | Differential regulation of gene expression by PITX2 isoforms. (Cox CJ, Espinoza HM, McWilliams B, Chappell K, Morton L, Hjalt TA, Semina EV, Amendt BA) J Biol Chem 2002 Jul 12;277(28):25001-10 142 Citations |
1 | Iron-sulfur cluster biosynthesis: characterization of Schizosaccharomyces pombe Isa1. (Wu G, Mansy SS, Hemann C, Hille R, Surerus KK, Cowan JA) J Biol Inorg Chem 2002 Apr;7(4-5):526-32 69 Citations |
1 | A molecular basis for differential developmental anomalies in Axenfeld-Rieger syndrome. (Espinoza HM, Cox CJ, Semina EV, Amendt BA) Hum Mol Genet 2002 Apr 01;11(7):743-53 57 Citations |
1 | Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4. (Cirillo LA, Lin FR, Cuesta I, Friedman D, Jarnik M, Zaret KS) Mol Cell 2002 Feb;9(2):279-89 959 Citations |
1 | Autocrine interleukin-6 production in renal cell carcinoma: evidence for the involvement of p53. (Angelo LS, Talpaz M, Kurzrock R) Cancer Res 2002 Feb 01;62(3):932-40 87 Citations |
1 | Endostatin causes G1 arrest of endothelial cells through inhibition of cyclin D1. (Hanai J, Dhanabal M, Karumanchi SA, Albanese C, Waterman M, Chan B, Ramchandran R, Pestell R, Sukhatme VP) J Biol Chem 2002 May 10;277(19):16464-9 221 Citations |
1 | Heat shock factor 1-mediated thermotolerance prevents cell death and results in G2/M cell cycle arrest. (Luft JC, Benjamin IJ, Mestril R, Dix DJ) Cell Stress Chaperones 2001 Oct;6(4):326-36 48 Citations |
1 | Heat shock factor 1 and heat shock proteins: critical partners in protection against acute cell injury. (Christians ES, Yan LJ, Benjamin IJ) Crit Care Med 2002 Jan;30(1 Suppl):S43-50 191 Citations |
1 | The E2F1-3 transcription factors are essential for cellular proliferation. (Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT, Nuckolls F, Giangrande P, Wright FA, Field SJ, Greenberg ME, Orkin S, Nevins JR, Robinson ML, Leone G) Nature 2001 Nov 22;414(6862):457-62 519 Citations |
1 | PU.1/Spi-B regulation of c-rel is essential for mature B cell survival. (Hu CJ, Rao S, Ramirez-Bergeron DL, Garrett-Sinha LA, Gerondakis S, Clark MR, Simon MC) Immunity 2001 Oct;15(4):545-55 42 Citations |
1 | Immunohistochemical expression of cell cycle proteins E2F-1, Cdk-2, Cyclin E, p27(kip1), and Ki-67 in normal placenta and gestational trophoblastic disease. (Olvera M, Harris S, Amezcua CA, McCourty A, Rezk S, Koo C, Felix JC, Brynes RK) Mod Pathol 2001 Oct;14(10):1036-42 43 Citations |
1 | Distal limb malformations: underlying mechanisms and clinical associations. (Sifakis S, Basel D, Ianakiev P, Kilpatrick M, Tsipouras P) Clin Genet 2001 Sep;60(3):165-72 33 Citations |
1 | Critical roles of a cyclic AMP responsive element and an E-box in regulation of mouse renin gene expression. (Pan L, Black TA, Shi Q, Jones CA, Petrovic N, Loudon J, Kane C, Sigmund CD, Gross KW) J Biol Chem 2001 Dec 07;276(49):45530-8 114 Citations |
1 | 7-Dehydrocholesterol-dependent proteolysis of HMG-CoA reductase suppresses sterol biosynthesis in a mouse model of Smith-Lemli-Opitz/RSH syndrome. (Fitzky BU, Moebius FF, Asaoka H, Waage-Baudet H, Xu L, Xu G, Maeda N, Kluckman K, Hiller S, Yu H, Batta AK, Shefer S, Chen T, Salen G, Sulik K, Simoni RD, Ness GC, Glossmann H, Patel SB, Tint GS) J Clin Invest 2001 Sep;108(6):905-15 146 Citations |
1 | Oxygen-dependent expression of hypoxia-inducible factor-1alpha in renal medullary cells of rats. (Zou AP, Yang ZZ, Li PL, Cowley AW JR) Physiol Genomics 2001 Aug 28;6(3):159-68 50 Citations |
1 | Magnitude of peroxisome proliferator-activated receptor-gamma activation is associated with important and seemingly opposite biological responses in breast cancer cells. (Clay CE, Namen AM, Atsumi G, Trimboli AJ, Fonteh AN, High KP, Chilton FH) J Investig Med 2001 Sep;49(5):413-20 64 Citations |
1 | Myc requires distinct E2F activities to induce S phase and apoptosis. (Leone G, Sears R, Huang E, Rempel R, Nuckolls F, Park CH, Giangrande P, Wu L, Saavedra HI, Field SJ, Thompson MA, Yang H, Fujiwara Y, Greenberg ME, Orkin S, Smith C, Nevins JR) Mol Cell 2001 Jul;8(1):105-13 217 Citations |
1 | HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation. (Yu F, White SB, Zhao Q, Lee FS) Proc Natl Acad Sci U S A 2001 Aug 14;98(17):9630-5 708 Citations |
1 | Structure and topology of a peptide segment of the 6th transmembrane domain of the Saccharomyces cerevisae alpha-factor receptor in phospholipid bilayers. (Valentine KG, Liu SF, Marassi FM, Veglia G, Opella SJ, Ding FX, Wang SH, Arshava B, Becker JM, Naider F) Biopolymers 2001 Oct 05;59(4):243-56 43 Citations |
1 | Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis. (Ishida S, Huang E, Zuzan H, Spang R, Leone G, West M, Nevins JR) Mol Cell Biol 2001 Jul;21(14):4684-99 515 Citations |
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