Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Balaraman Kalyanaraman PhD

Balaraman Kalyanaraman PhD

Chairman, Professor

Institution: Medical College of Wisconsin
Department: Biophysics
Program: Research


Publications

  • Detection and identification of oxidants formed during •NO/O2•⁻ reaction: a multi-well plate CW-EPR spectroscopy combined with HPLC analyses. (Koto T, Michalski R, Zielonka J, Joseph J, Kalyanaraman B) Free Radic Res 2014 Apr;48(4):478-86 PMID 24460755
  • On the use of fluorescence lifetime imaging and dihydroethidium to detect superoxide in intact animals and ex vivo tissues: a reassessment. (Michalski R, Michalowski B, Sikora A, Zielonka J, Kalyanaraman B) Free Radic Biol Med 2014 Feb;67:278-84 PMID 24200598
  • Oxidative stress induced mitochondrial protein kinase A mediates cytochrome C oxidase dysfunction. (Srinivasan S, Spear J, Chandran K, Joseph J, Kalyanaraman B, Avadhani NG) PLoS One 2013;8(10):e77129 PMID 24130844
  • On the use of L-012, a luminol-based chemiluminescent probe, for detecting superoxide and identifying inhibitors of NADPH oxidase: a reevaluation. (Zielonka J, Lambeth JD, Kalyanaraman B) Free Radic Biol Med 2013 Dec;65:1310-4 PMID 24080119
  • Mitochondria-targeted antioxidants for treatment of Parkinson's disease: Preclinical and clinical outcomes. (Jin H, Kanthasamy A, Ghosh A, Anantharam V, Kalyanaraman B, Kanthasamy AG) Biochim Biophys Acta 2013 Sep 20: PMID 24060637
  • iNOS expression and NO production contribute to the direct effects of BCG on urothelial carcinoma cell biology. (Shah G, Zhang G, Chen F, Cao Y, Kalyanaraman B, See WA) Urol Oncol 2014 Jan;32(1):45.e1-9 PMID 24054867
  • Loss of bacillus Calmette-Guérin viability adversely affects the direct response of urothelial carcinoma cells to bacillus Calmette-Guérin exposure. (Shah G, Zhang G, Chen F, Cao Y, Kalyanaraman B, See W) J Urol 2014 Mar;191(3):823-9 PMID 24035882
  • Teaching the basics of redox biology to medical and graduate students: Oxidants, antioxidants and disease mechanisms. (Kalyanaraman B) Redox Biol 2013;1(1):244-257 PMID 24024158
  • Mito-tempol and dexrazoxane exhibit cardioprotective and chemotherapeutic effects through specific protein oxidation and autophagy in a syngeneic breast tumor preclinical model. (Dickey JS, Gonzalez Y, Aryal B, Mog S, Nakamura AJ, Redon CE, Baxa U, Rosen E, Cheng G, Zielonka J, Parekh P, Mason KP, Joseph J, Kalyanaraman B, Bonner W, Herman E, Shacter E, Rao VA) PLoS One 2013;8(8):e70575 PMID 23940596
  • Mitochondria-targeted antioxidant and glycolysis inhibition: synergistic therapy in hepatocellular carcinoma. (Dilip A, Cheng G, Joseph J, Kunnimalaiyaan S, Kalyanaraman B, Kunnimalaiyaan M, Gamblin TC) Anticancer Drugs 2013 Oct;24(9):881-8 PMID 23872912
  • Real-time monitoring of reactive oxygen and nitrogen species in a multiwell plate using the diagnostic marker products of specific probes. (Zielonka J, Joseph J, Sikora A, Kalyanaraman B) Methods Enzymol 2013;526:145-57 PMID 23791099
  • Mitochondria-targeted vitamin E analogs inhibit breast cancer cell energy metabolism and promote cell death. (Cheng G, Zielonka J, McAllister DM, Mackinnon AC Jr, Joseph J, Dwinell MB, Kalyanaraman B) BMC Cancer 2013;13:285 PMID 23764021
  • The first purification and unequivocal characterization of the radical form of the carbon-centered quinone ketoxy radical adduct. (Huang CH, Shan GQ, Mao L, Kalyanaraman B, Qin H, Ren FR, Zhu BZ) Chem Commun (Camb) 2013 Jul 21;49(57):6436-8 PMID 23752136
  • Diapocynin prevents early Parkinson's disease symptoms in the leucine-rich repeat kinase 2 (LRRK2R¹⁴⁴¹G) transgenic mouse. (Dranka BP, Gifford A, Ghosh A, Zielonka J, Joseph J, Kanthasamy AG, Kalyanaraman B) Neurosci Lett 2013 Aug 9;549:57-62 PMID 23721786
  • An adenosine-mediated signaling pathway suppresses prenylation of the GTPase Rap1B and promotes cell scattering. (Ntantie E, Gonyo P, Lorimer EL, Hauser AD, Schuld N, McAllister D, Kalyanaraman B, Dwinell MB, Auchampach JA, Williams CL) Sci Signal 2013 May 28;6(277):ra39 PMID 23716716
  • Molecular mechanism of metal-independent decomposition of lipid hydroperoxide 13-HPODE by halogenated quinoid carcinogens. (Qin H, Huang CH, Mao L, Xia HY, Kalyanaraman B, Shao J, Shan GQ, Zhu BZ) Free Radic Biol Med 2013 Oct;63:459-66 PMID 23680403
  • HPLC-based monitoring of products formed from hydroethidine-based fluorogenic probes--the ultimate approach for intra- and extracellular superoxide detection. (Kalyanaraman B, Dranka BP, Hardy M, Michalski R, Zielonka J) Biochim Biophys Acta 2014 Feb;1840(2):739-44 PMID 23668959
  • Reaction between peroxynitrite and triphenylphosphonium-substituted arylboronic acid isomers: identification of diagnostic marker products and biological implications. (Sikora A, Zielonka J, Adamus J, Debski D, Dybala-Defratyka A, Michalowski B, Joseph J, Hartley RC, Murphy MP, Kalyanaraman B) Chem Res Toxicol 2013 Jun 17;26(6):856-67 PMID 23611338
  • Redox activation of Fe(III)-thiosemicarbazones and Fe(III)-bleomycin by thioredoxin reductase: specificity of enzymatic redox centers and analysis of reactive species formation by ESR spin trapping. (Myers JM, Cheng Q, Antholine WE, Kalyanaraman B, Filipovska A, Arnér ES, Myers CR) Free Radic Biol Med 2013 Jul;60:183-94 PMID 23485585
  • Potent methyl oxidation of 5-methyl-2'-deoxycytidine by halogenated quinoid carcinogens and hydrogen peroxide via a metal-independent mechanism. (Shao J, Huang CH, Kalyanaraman B, Zhu BZ) Free Radic Biol Med 2013 Jul;60:177-82 PMID 23376470
  • Peroxynitrite formation in nitric oxide-exposed submitochondrial particles: detection, oxidative damage and catalytic removal by Mn-porphyrins. (Valez V, Cassina A, Batinic-Haberle I, Kalyanaraman B, Ferrer-Sueta G, Radi R) Arch Biochem Biophys 2013 Jan 1;529(1):45-54 PMID 23142682
  • Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson's disease. (Ghosh A, Kanthasamy A, Joseph J, Anantharam V, Srivastava P, Dranka BP, Kalyanaraman B, Kanthasamy AG) J Neuroinflammation 2012;9:241 PMID 23092448
  • Hydropropidine: a novel, cell-impermeant fluorogenic probe for detecting extracellular superoxide. (Michalski R, Zielonka J, Hardy M, Joseph J, Kalyanaraman B) Free Radic Biol Med 2013 Jan;54:135-47 PMID 23051008
  • Mitochondrial-targeted nitroxides disrupt mitochondrial architecture and inhibit expression of peroxiredoxin 3 and FOXM1 in malignant mesothelioma cells. (Cunniff B, Benson K, Stumpff J, Newick K, Held P, Taatjes D, Joseph J, Kalyanaraman B, Heintz NH) J Cell Physiol 2013 Apr;228(4):835-45 PMID 23018647
  • Unprecedented hydroxyl radical-dependent two-step chemiluminescence production by polyhalogenated quinoid carcinogens and H2O2. (Zhu BZ, Mao L, Huang CH, Qin H, Fan RM, Kalyanaraman B, Zhu JG) Proc Natl Acad Sci U S A 2012 Oct 2;109(40):16046-51 PMID 22988069
  • Boronate probes as diagnostic tools for real time monitoring of peroxynitrite and hydroperoxides. (Zielonka J, Sikora A, Hardy M, Joseph J, Dranka BP, Kalyanaraman B) Chem Res Toxicol 2012 Sep 17;25(9):1793-9 PMID 22731669
  • Alterations in bioenergetic function induced by Parkinson's disease mimetic compounds: lack of correlation with superoxide generation. (Dranka BP, Zielonka J, Kanthasamy AG, Kalyanaraman B) J Neurochem 2012 Sep;122(5):941-51 PMID 22708893
  • Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia-reperfusion: therapeutic potential of mitochondrially targeted antioxidants. (Mukhopadhyay P, Horváth B, Zsengellėr Z, Bátkai S, Cao Z, Kechrid M, Holovac E, Erdėlyi K, Tanchian G, Liaudet L, Stillman IE, Joseph J, Kalyanaraman B, Pacher P) Free Radic Biol Med 2012 Sep 1;53(5):1123-38 PMID 22683818
  • Molecular basis of intramolecular electron transfer in proteins during radical-mediated oxidations: computer simulation studies in model tyrosine-cysteine peptides in solution. (Petruk AA, Bartesaghi S, Trujillo M, Estrin DA, Murgida D, Kalyanaraman B, Marti MA, Radi R) Arch Biochem Biophys 2012 Sep 1;525(1):82-91 PMID 22640642
  • Cisplatin nephrotoxicity involves mitochondrial injury with impaired tubular mitochondrial enzyme activity. (Zsengellér ZK, Ellezian L, Brown D, Horváth B, Mukhopadhyay P, Kalyanaraman B, Parikh SM, Karumanchi SA, Stillman IE, Pacher P) J Histochem Cytochem 2012 Jul;60(7):521-9 PMID 22511597
  • Mitochondria-targeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell death. (Cheng G, Zielonka J, Dranka BP, McAllister D, Mackinnon AC Jr, Joseph J, Kalyanaraman B) Cancer Res 2012 May 15;72(10):2634-44 PMID 22431711
  • Additive effects of mitochondrion-targeted cytochrome CYP2E1 and alcohol toxicity on cytochrome c oxidase function and stability of respirosome complexes. (Bansal S, Srinivasan S, Anandasadagopan S, Chowdhury AR, Selvaraj V, Kalyanaraman B, Joseph J, Avadhani NG) J Biol Chem 2012 May 4;287(19):15284-97 PMID 22396533
  • Particulate matter Air Pollution induces hypermethylation of the p16 promoter Via a mitochondrial ROS-JNK-DNMT1 pathway. (Soberanes S, Gonzalez A, Urich D, Chiarella SE, Radigan KA, Osornio-Vargas A, Joseph J, Kalyanaraman B, Ridge KM, Chandel NS, Mutlu GM, De Vizcaya-Ruiz A, Budinger GR) Sci Rep 2012;2:275 PMID 22355787
  • Global profiling of reactive oxygen and nitrogen species in biological systems: high-throughput real-time analyses. (Zielonka J, Zielonka M, Sikora A, Adamus J, Joseph J, Hardy M, Ouari O, Dranka BP, Kalyanaraman B) J Biol Chem 2012 Jan 27;287(5):2984-95 PMID 22139901
  • Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy. (Mukhopadhyay P, Horváth B, Zsengellér Z, Zielonka J, Tanchian G, Holovac E, Kechrid M, Patel V, Stillman IE, Parikh SM, Joseph J, Kalyanaraman B, Pacher P) Free Radic Biol Med 2012 Jan 15;52(2):497-506 PMID 22120494
  • Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations. (Kalyanaraman B, Darley-Usmar V, Davies KJ, Dennery PA, Forman HJ, Grisham MB, Mann GE, Moore K, Roberts LJ 2nd, Ischiropoulos H) Free Radic Biol Med 2012 Jan 1;52(1):1-6 PMID 22027063
  • Mitochondrial complex III ROS regulate adipocyte differentiation. (Tormos KV, Anso E, Hamanaka RB, Eisenbart J, Joseph J, Kalyanaraman B, Chandel NS) Cell Metab 2011 Oct 5;14(4):537-44 PMID 21982713
  • Oxidative chemistry of fluorescent dyes: implications in the detection of reactive oxygen and nitrogen species. (Kalyanaraman B) Biochem Soc Trans 2011 Oct;39(5):1221-5 PMID 21936793
  • Diapocynin and apocynin administration fails to significantly extend survival in G93A SOD1 ALS mice. (Trumbull KA, McAllister D, Gandelman MM, Fung WY, Lew T, Brennan L, Lopez N, Morré J, Kalyanaraman B, Beckman JS) Neurobiol Dis 2012 Jan;45(1):137-44 PMID 21820513
  • Mitochondria-targeted nitroxides exacerbate fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells. (Cheng G, Lopez M, Zielonka J, Hauser AD, Joseph J, McAllister D, Rowe JJ, Sugg SL, Williams CL, Kalyanaraman B) Cancer Biol Ther 2011 Oct 15;12(8):707-17 PMID 21799303
  • Mitochondria-targeted ubiquinone (MitoQ) decreases ethanol-dependent micro and macro hepatosteatosis. (Chacko BK, Srivastava A, Johnson MS, Benavides GA, Chang MJ, Ye Y, Jhala N, Murphy MP, Kalyanaraman B, Darley-Usmar VM) Hepatology 2011 Jul;54(1):153-63 PMID 21520201
  • Unraveling the biological roles of reactive oxygen species. (Murphy MP, Holmgren A, Larsson NG, Halliwell B, Chang CJ, Kalyanaraman B, Rhee SG, Thornalley PJ, Partridge L, Gems D, Nyström T, Belousov V, Schumacker PT, Winterbourn CC) Cell Metab 2011 Apr 6;13(4):361-6 PMID 21459321
  • Reaction between peroxynitrite and boronates: EPR spin-trapping, HPLC Analyses, and quantum mechanical study of the free radical pathway. (Sikora A, Zielonka J, Lopez M, Dybala-Defratyka A, Joseph J, Marcinek A, Kalyanaraman B) Chem Res Toxicol 2011 May 16;24(5):687-97 PMID 21434648
  • Analysis of proteome changes in doxorubicin-treated adult rat cardiomyocyte. (Kumar SN, Konorev EA, Aggarwal D, Kalyanaraman B) J Proteomics 2011 May 1;74(5):683-97 PMID 21338723
  • Tyrosine-lipid peroxide adducts from radical termination: para coupling and intramolecular Diels-Alder cyclization. (Shchepin R, Möller MN, Kim HY, Hatch DM, Bartesaghi S, Kalyanaraman B, Radi R, Porter NA) J Am Chem Soc 2010 Dec 15;132(49):17490-500 PMID 21090613
  • Detoxifying carcinogenic polyhalogenated quinones by hydroxamic acids via an unusual double Lossen rearrangement mechanism. (Zhu BZ, Zhu JG, Mao L, Kalyanaraman B, Shan GQ) Proc Natl Acad Sci U S A 2010 Nov 30;107(48):20686-90 PMID 21076034
  • Ergothioneine prevents copper-induced oxidative damage to DNA and protein by forming a redox-inactive ergothioneine-copper complex. (Zhu BZ, Mao L, Fan RM, Zhu JG, Zhang YN, Wang J, Kalyanaraman B, Frei B) Chem Res Toxicol 2011 Jan 14;24(1):30-4 PMID 21047085
  • Oxidation of histidine residues in copper-zinc superoxide dismutase by bicarbonate-stimulated peroxidase and thiol oxidase activities: pulse EPR and NMR studies. (Chandran K, McCracken J, Peterson FC, Antholine WE, Volkman BF, Kalyanaraman B) Biochemistry 2010 Dec 21;49(50):10616-22 PMID 21038859
  • Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model. (Ghosh A, Chandran K, Kalivendi SV, Joseph J, Antholine WE, Hillard CJ, Kanthasamy A, Kanthasamy A, Kalyanaraman B) Free Radic Biol Med 2010 Dec 1;49(11):1674-84 PMID 20828611
  • Prevention of diabetic nephropathy in Ins2(+/)⁻(AkitaJ) mice by the mitochondria-targeted therapy MitoQ. (Chacko BK, Reily C, Srivastava A, Johnson MS, Ye Y, Ulasova E, Agarwal A, Zinn KR, Murphy MP, Kalyanaraman B, Darley-Usmar V) Biochem J 2010 Nov 15;432(1):9-19 PMID 20825366
  • The antioxidant transcription factor Nrf2 negatively regulates autophagy and growth arrest induced by the anticancer redox agent mitoquinone. (Rao VA, Klein SR, Bonar SJ, Zielonka J, Mizuno N, Dickey JS, Keller PW, Joseph J, Kalyanaraman B, Shacter E) J Biol Chem 2010 Nov 5;285(45):34447-59 PMID 20805228
  • Reactive oxygen species control senescence-associated matrix metalloproteinase-1 through c-Jun-N-terminal kinase. (Dasgupta J, Kar S, Liu R, Joseph J, Kalyanaraman B, Remington SJ, Chen C, Melendez JA) J Cell Physiol 2010 Oct;225(1):52-62 PMID 20648623
  • NADPH oxidase 2 mediates intermittent hypoxia-induced mitochondrial complex I inhibition: relevance to blood pressure changes in rats. (Khan SA, Nanduri J, Yuan G, Kinsman B, Kumar GK, Joseph J, Kalyanaraman B, Prabhakar NR) Antioxid Redox Signal 2011 Feb 15;14(4):533-42 PMID 20618070
  • The selenium-independent inherent pro-oxidant NADPH oxidase activity of mammalian thioredoxin reductase and its selenium-dependent direct peroxidase activities. (Cheng Q, Antholine WE, Myers JM, Kalyanaraman B, Arnér ES, Myers CR) J Biol Chem 2010 Jul 9;285(28):21708-23 PMID 20457604
  • Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. (Weinberg F, Hamanaka R, Wheaton WW, Weinberg S, Joseph J, Lopez M, Kalyanaraman B, Mutlu GM, Budinger GR, Chandel NS) Proc Natl Acad Sci U S A 2010 May 11;107(19):8788-93 PMID 20421486
  • Role of mitochondrial reactive oxygen species in osteoclast differentiation. (Srinivasan S, Koenigstein A, Joseph J, Sun L, Kalyanaraman B, Zaidi M, Avadhani NG) Ann N Y Acad Sci 2010 Mar;1192:245-52 PMID 20392243
  • Peroxynitrite is the major species formed from different flux ratios of co-generated nitric oxide and superoxide: direct reaction with boronate-based fluorescent probe. (Zielonka J, Sikora A, Joseph J, Kalyanaraman B) J Biol Chem 2010 May 7;285(19):14210-6 PMID 20194496
  • Lipid peroxyl radicals mediate tyrosine dimerization and nitration in membranes. (Bartesaghi S, Wenzel J, Trujillo M, López M, Joseph J, Kalyanaraman B, Radi R) Chem Res Toxicol 2010 Apr 19;23(4):821-35 PMID 20170094
  • Hydroethidine- and MitoSOX-derived red fluorescence is not a reliable indicator of intracellular superoxide formation: another inconvenient truth. (Zielonka J, Kalyanaraman B) Free Radic Biol Med 2010 Apr 15;48(8):983-1001 PMID 20116425
  • Mitochondrial targeting of the electrophilic lipid 15-deoxy-Delta12,14-prostaglandin J2 increases apoptotic efficacy via redox cell signalling mechanisms. (Diers AR, Higdon AN, Ricart KC, Johnson MS, Agarwal A, Kalyanaraman B, Landar A, Darley-Usmar VM) Biochem J 2010 Feb 15;426(1):31-41 PMID 19916962
  • A (99m)Tc-labeled triphenylphosphonium derivative for the early detection of breast tumors. (Li Z, Lopez M, Hardy M, McAllister DM, Kalyanaraman B, Zhao M) Cancer Biother Radiopharm 2009 Oct;24(5):579-87 PMID 19877888
  • Physiological fluctuation of (99m)Tc-sestamibi uptake in normal mammary glands: a systematic investigation in female rats. (Larson M, Larson M, Li Z, Larson M, Li Z, Hall CL, Jensen E, McAllister DM, Kalyanaraman B, Zhao M) Acta Radiol 2009 Nov;50(9):975-8 PMID 19863405
  • Oxidants induce alternative splicing of alpha-synuclein: Implications for Parkinson's disease. (Kalivendi SV, Yedlapudi D, Hillard CJ, Kalyanaraman B) Free Radic Biol Med 2010 Feb 1;48(3):377-83 PMID 19857570
  • Mitochondrially targeted antioxidants for the treatment of cardiovascular diseases. (Subramanian S, Kalyanaraman B, Migrino RQ) Recent Pat Cardiovasc Drug Discov 2010 Jan;5(1):54-65 PMID 19807685
  • Direct oxidation of boronates by peroxynitrite: mechanism and implications in fluorescence imaging of peroxynitrite. (Sikora A, Zielonka J, Lopez M, Joseph J, Kalyanaraman B) Free Radic Biol Med 2009 Nov 15;47(10):1401-7 PMID 19686842
  • Decreased S-nitrosation of peptide thiols in the membrane interior. (Zhang H, Andrekopoulos C, Xu Y, Joseph J, Hogg N, Feix J, Kalyanaraman B) Free Radic Biol Med 2009 Oct 1;47(7):962-8 PMID 19573593
  • Metal-independent decomposition of hydroperoxides by halogenated quinones: detection and identification of a quinone ketoxy radical. (Zhu BZ, Shan GQ, Huang CH, Kalyanaraman B, Mao L, Du YG) Proc Natl Acad Sci U S A 2009 Jul 14;106(28):11466-71 PMID 19556549
  • Role of nuclear-encoded subunit Vb in the assembly and stability of cytochrome c oxidase complex: implications in mitochondrial dysfunction and ROS production. (Galati D, Srinivasan S, Raza H, Prabu SK, Hardy M, Chandran K, Lopez M, Kalyanaraman B, Avadhani NG) Biochem J 2009 Jun 15;420(3):439-49 PMID 19338496
  • Doxorubicin inactivates myocardial cytochrome c oxidase in rats: cardioprotection by Mito-Q. (Chandran K, Aggarwal D, Migrino RQ, Joseph J, McAllister D, Konorev EA, Antholine WE, Zielonka J, Srinivasan S, Avadhani NG, Kalyanaraman B) Biophys J 2009 Feb 18;96(4):1388-98 PMID 19217856
  • The effect of neighboring methionine residue on tyrosine nitration and oxidation in peptides treated with MPO, H2O2, and NO2(-) or peroxynitrite and bicarbonate: role of intramolecular electron transfer mechanism? (Zhang H, Zielonka J, Sikora A, Joseph J, Xu Y, Kalyanaraman B) Arch Biochem Biophys 2009 Apr 15;484(2):134-45 PMID 19056332
  • HPLC study of oxidation products of hydroethidine in chemical and biological systems: ramifications in superoxide measurements. (Zielonka J, Hardy M, Kalyanaraman B) Free Radic Biol Med 2009 Feb 1;46(3):329-38 PMID 19026738
  • Differences in doxorubicin-induced apoptotic signaling in adult and immature cardiomyocytes. (Konorev EA, Vanamala S, Kalyanaraman B) Free Radic Biol Med 2008 Dec 15;45(12):1723-8 PMID 18926904
  • "ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis"--a critical commentary. (Zielonka J, Kalyanaraman B) Free Radic Biol Med 2008 Nov 1;45(9):1217-9 PMID 18789385
  • Cytokines and lipopolysaccharides induce inducible nitric oxide synthase but not enzyme activity in adult rat cardiomyocytes. (Vásquez-Vivar J, Whitsett J, Ionova I, Konorev E, Zielonka J, Kalyanaraman B, Shi Y, Pieper GM) Free Radic Biol Med 2008 Oct 1;45(7):994-1001 PMID 18634867
  • Tyrosine nitration, dimerization, and hydroxylation by peroxynitrite in membranes as studied by the hydrophobic probe N-t-BOC-l-tyrosine tert-butyl ester. (Bartesaghi S, Peluffo G, Zhang H, Joseph J, Kalyanaraman B, Radi R) Methods Enzymol 2008;441:217-36 PMID 18554537
  • Redox-based regulation of signal transduction: principles, pitfalls, and promises. (Janssen-Heininger YM, Mossman BT, Heintz NH, Forman HJ, Kalyanaraman B, Finkel T, Stamler JS, Rhee SG, van der Vliet A) Free Radic Biol Med 2008 Jul 1;45(1):1-17 PMID 18423411
  • Influence of intramolecular electron transfer mechanism in biological nitration, nitrosation, and oxidation of redox-sensitive amino acids. (Zhang H, Xu Y, Joseph J, Kalyanaraman B) Methods Enzymol 2008;440:65-94 PMID 18423211
  • L-Xylulose reductase is involved in 9,10-phenanthrenequinone-induced apoptosis in human T lymphoma cells. (Matsunaga T, Kamiya T, Sumi D, Kumagai Y, Kalyanaraman B, Hara A) Free Radic Biol Med 2008 Mar 15;44(6):1191-202 PMID 18206670
  • Detection of 2-hydroxyethidium in cellular systems: a unique marker product of superoxide and hydroethidine. (Zielonka J, Vasquez-Vivar J, Kalyanaraman B) Nat Protoc 2008;3(1):8-21 PMID 18193017
  • Cytochrome c-mediated oxidation of hydroethidine and mito-hydroethidine in mitochondria: identification of homo- and heterodimers. (Zielonka J, Srinivasan S, Hardy M, Ouari O, Lopez M, Vasquez-Vivar J, Avadhani NG, Kalyanaraman B) Free Radic Biol Med 2008 Mar 1;44(5):835-46 PMID 18155177
  • Molecular mechanism for metal-independent production of hydroxyl radicals by hydrogen peroxide and halogenated quinones. (Zhu BZ, Kalyanaraman B, Jiang GB) Proc Natl Acad Sci U S A 2007 Nov 6;104(45):17575-8 PMID 17968010
  • Incorporation of the hydrophobic probe N-t-BOC-L-tyrosine tert-butyl ester to red blood cell membranes to study peroxynitrite-dependent reactions. (Romero N, Peluffo G, Bartesaghi S, Zhang H, Joseph J, Kalyanaraman B, Radi R) Chem Res Toxicol 2007 Nov;20(11):1638-48 PMID 17941688
  • Early detection of doxorubicin cardiomyopathy using two-dimensional strain echocardiography. (Migrino RQ, Aggarwal D, Konorev E, Brahmbhatt T, Bright M, Kalyanaraman B) Ultrasound Med Biol 2008 Feb;34(2):208-14 PMID 17935867
  • Statin-induced breast cancer cell death: role of inducible nitric oxide and arginase-dependent pathways. (Kotamraju S, Williams CL, Kalyanaraman B) Cancer Res 2007 Aug 1;67(15):7386-94 PMID 17671209
  • Iron signaling and oxidant damage. (Kalyanaraman B) Cardiovasc Toxicol 2007;7(2):92-4 PMID 17652811
  • Detection, characterization, and decay kinetics of ROS and thiyl adducts of mito-DEPMPO spin trap. (Hardy M, Rockenbauer A, Vásquez-Vivar J, Felix C, Lopez M, Srinivasan S, Avadhani N, Tordo P, Kalyanaraman B) Chem Res Toxicol 2007 Jul;20(7):1053-60 PMID 17559235
  • Mechanism of metal-independent decomposition of organic hydroperoxides and formation of alkoxyl radicals by halogenated quinones. (Zhu BZ, Zhao HT, Kalyanaraman B, Liu J, Shan GQ, Du YG, Frei B) Proc Natl Acad Sci U S A 2007 Mar 6;104(10):3698-702 PMID 17360415
  • Hydrogen peroxide induces nitric oxide and proteosome activity in endothelial cells: a bell-shaped signaling response. (Thomas S, Kotamraju S, Zielonka J, Harder DR, Kalyanaraman B) Free Radic Biol Med 2007 Apr 1;42(7):1049-61 PMID 17349932
  • Mito-DEPMPO synthesized from a novel NH2-reactive DEPMPO spin trap: a new and improved trap for the detection of superoxide. (Hardy M, Chalier F, Ouari O, Finet JP, Rockenbauer A, Kalyanaraman B, Tordo P) Chem Commun (Camb) 2007 Mar 14(10):1083-5 PMID 17325813
  • Reduction of hexavalent chromium by human cytochrome b5: generation of hydroxyl radical and superoxide. (Borthiry GR, Antholine WE, Kalyanaraman B, Myers JM, Myers CR) Free Radic Biol Med 2007 Mar 15;42(6):738-55; discussion 735-7 PMID 17320757
  • Increased arginase activity and endothelial dysfunction in human inflammatory bowel disease. (Horowitz S, Binion DG, Nelson VM, Kanaa Y, Javadi P, Lazarova Z, Andrekopoulos C, Kalyanaraman B, Otterson MF, Rafiee P) Am J Physiol Gastrointest Liver Physiol 2007 May;292(5):G1323-36 PMID 17218473
  • Synthesis and ESR studies of a novel cyclic nitrone spin trap attached to a phosphonium group-a suitable trap for mitochondria-generated ROS? (Xu Y, Kalyanaraman B) Free Radic Res 2007 Jan;41(1):1-7 PMID 17164173
  • Pulse radiolysis and steady-state analyses of the reaction between hydroethidine and superoxide and other oxidants. (Zielonka J, Sarna T, Roberts JE, Wishart JF, Kalyanaraman B) Arch Biochem Biophys 2006 Dec 1;456(1):39-47 PMID 17081495
  • Protein tyrosine nitration in hydrophilic and hydrophobic environments. (Bartesaghi S, Ferrer-Sueta G, Peluffo G, Valez V, Zhang H, Kalyanaraman B, Radi R) Amino Acids 2007;32(4):501-15 PMID 17077966
  • The confounding effects of light, sonication, and Mn(III)TBAP on quantitation of superoxide using hydroethidine. (Zielonka J, Vasquez-Vivar J, Kalyanaraman B) Free Radic Biol Med 2006 Oct 1;41(7):1050-7 PMID 16962930
  • Mechanistic studies of peroxynitrite-mediated tyrosine nitration in membranes using the hydrophobic probe N-t-BOC-L-tyrosine tert-butyl ester. (Bartesaghi S, Valez V, Trujillo M, Peluffo G, Romero N, Zhang H, Kalyanaraman B, Radi R) Biochemistry 2006 Jun 6;45(22):6813-25 PMID 16734418
  • Endothelial cell superoxide anion radical generation is not dependent on endothelial nitric oxide synthase-serine 1179 phosphorylation and endothelial nitric oxide synthase dimer/monomer distribution. (Whitsett J, Martásek P, Zhao H, Schauer DW, Hatakeyama K, Kalyanaraman B, Vásquez-Vivar J) Free Radic Biol Med 2006 Jun 1;40(11):2056-68 PMID 16716906
  • Cyclooxygenase 2 rescues LNCaP prostate cancer cells from sanguinarine-induced apoptosis by a mechanism involving inhibition of nitric oxide synthase activity. (Huh J, Liepins A, Zielonka J, Andrekopoulos C, Kalyanaraman B, Sorokin A) Cancer Res 2006 Apr 1;66(7):3726-36 PMID 16585199
  • Upregulation of immunoproteasomes by nitric oxide: potential antioxidative mechanism in endothelial cells. (Kotamraju S, Matalon S, Matsunaga T, Shang T, Hickman-Davis JM, Kalyanaraman B) Free Radic Biol Med 2006 Mar 15;40(6):1034-44 PMID 16540399
  • Hydrophobic tyrosyl probes for monitoring nitration reactions in membranes. (Zhang H, Joseph J, Kalyanaraman B) Methods Enzymol 2005;396:182-204 PMID 16291233
  • Nitric oxide, proteasomal function, and iron homeostasis--implications in aging and neurodegenerative diseases. (Kotamraju S, Kalivendi S, Shang T, Kalyanaraman B) Methods Enzymol 2005;396:526-34 PMID 16291259
  • Sepiapterin attenuates 1-methyl-4-phenylpyridinium-induced apoptosis in neuroblastoma cells transfected with neuronal NOS: role of tetrahydrobiopterin, nitric oxide, and proteasome activation. (Shang T, Kotamraju S, Zhao H, Kalivendi SV, Hillard CJ, Kalyanaraman B) Free Radic Biol Med 2005 Oct 15;39(8):1059-74 PMID 16198233
  • Intramolecular electron transfer between tyrosyl radical and cysteine residue inhibits tyrosine nitration and induces thiyl radical formation in model peptides treated with myeloperoxidase, H2O2, and NO2-: EPR SPIN trapping studies. (Zhang H, Xu Y, Joseph J, Kalyanaraman B) J Biol Chem 2005 Dec 9;280(49):40684-98 PMID 16176930
  • Mechanistic similarities between oxidation of hydroethidine by Fremy's salt and superoxide: stopped-flow optical and EPR studies. (Zielonka J, Zhao H, Xu Y, Kalyanaraman B) Free Radic Biol Med 2005 Oct 1;39(7):853-63 PMID 16140206
  • Motor neuron degeneration promotes neural progenitor cell proliferation, migration, and neurogenesis in the spinal cords of amyotrophic lateral sclerosis mice. (Chi L, Ke Y, Luo C, Li B, Gozal D, Kalyanaraman B, Liu R) Stem Cells 2006 Jan;24(1):34-43 PMID 16099995
  • Death-associated protein kinase as a sensor of mitochondrial membrane potential: role of lysosome in mitochondrial toxin-induced cell death. (Shang T, Joseph J, Hillard CJ, Kalyanaraman B) J Biol Chem 2005 Oct 14;280(41):34644-53 PMID 16085644
  • Mitochondria superoxide dismutase mimetic inhibits peroxide-induced oxidative damage and apoptosis: role of mitochondrial superoxide. (Dhanasekaran A, Kotamraju S, Karunakaran C, Kalivendi SV, Thomas S, Joseph J, Kalyanaraman B) Free Radic Biol Med 2005 Sep 1;39(5):567-83 PMID 16085176
  • Identification of residues essential for carbohydrate recognition and cation dependence of the 46-kDa mannose 6-phosphate receptor. (Sun G, Zhao H, Kalyanaraman B, Dahms NM) Glycobiology 2005 Nov;15(11):1136-49 PMID 15972892
  • Peroxynitrite-derived carbonate and nitrogen dioxide radicals readily react with lipoic and dihydrolipoic acid. (Trujillo M, Folkes L, Bartesaghi S, Kalyanaraman B, Wardman P, Radi R) Free Radic Biol Med 2005 Jul 15;39(2):279-88 PMID 15964519
  • Reductive activation of Cr(Vi) by nitric oxide synthase. (Porter R, Jáchymová M, Martásek P, Kalyanaraman B, Vásquez-Vivar J) Chem Res Toxicol 2005 May;18(5):834-43 PMID 15892577
  • Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence. (Zhao H, Joseph J, Fales HM, Sokoloski EA, Levine RL, Vasquez-Vivar J, Kalyanaraman B) Proc Natl Acad Sci U S A 2005 Apr 19;102(16):5727-32 PMID 15824309
  • Evaluation of spin trapping agents and trapping conditions for detection of cell-generated reactive oxygen species. (Shi H, Timmins G, Monske M, Burdick A, Kalyanaraman B, Liu Y, Clément JL, Burchiel S, Liu KJ) Arch Biochem Biophys 2005 May 1;437(1):59-68 PMID 15820217
  • Doxorubicin activates nuclear factor of activated T-lymphocytes and Fas ligand transcription: role of mitochondrial reactive oxygen species and calcium. (Kalivendi SV, Konorev EA, Cunningham S, Vanamala SK, Kaji EH, Joseph J, Kalyanaraman B) Biochem J 2005 Jul 15;389(Pt 2):527-39 PMID 15799720
  • Thiol oxidase activity of copper, zinc superoxide dismutase stimulates bicarbonate-dependent peroxidase activity via formation of a carbonate radical. (Karunakaran C, Zhang H, Joseph J, Antholine WE, Kalyanaraman B) Chem Res Toxicol 2005 Mar;18(3):494-500 PMID 15777089
  • Changes in tetrahydrobiopterin levels in endothelial cells and adult cardiomyocytes induced by LPS and hydrogen peroxide--a role for GFRP? (Kalivendi S, Hatakeyama K, Whitsett J, Konorev E, Kalyanaraman B, Vásquez-Vivar J) Free Radic Biol Med 2005 Feb 15;38(4):481-91 PMID 15649650
  • Mass spectral evidence for carbonate-anion-radical-induced posttranslational modification of tryptophan to kynurenine in human Cu, Zn superoxide dismutase. (Zhang H, Joseph J, Crow J, Kalyanaraman B) Free Radic Biol Med 2004 Dec 15;37(12):2018-26 PMID 15544920
  • Nitrated lipids: a class of cell-signaling molecules. (Kalyanaraman B) Proc Natl Acad Sci U S A 2004 Aug 10;101(32):11527-8 PMID 15292510
  • Supplementation of endothelial cells with mitochondria-targeted antioxidants inhibit peroxide-induced mitochondrial iron uptake, oxidative damage, and apoptosis. (Dhanasekaran A, Kotamraju S, Kalivendi SV, Matsunaga T, Shang T, Keszler A, Joseph J, Kalyanaraman B) J Biol Chem 2004 Sep 3;279(36):37575-87 PMID 15220329
  • Impact of pulmonary arterial endothelial cells on duroquinone redox status. (Merker MP, Bongard RD, Krenz GS, Zhao H, Fernandes VS, Kalyanaraman B, Hogg N, Audi SH) Free Radic Biol Med 2004 Jul 1;37(1):86-103 PMID 15183197
  • The carbonate radical anion-induced covalent aggregation of human copper, zinc superoxide dismutase, and alpha-synuclein: intermediacy of tryptophan- and tyrosine-derived oxidation products. (Zhang H, Andrekopoulos C, Joseph J, Crow J, Kalyanaraman B) Free Radic Biol Med 2004 Jun 1;36(11):1355-65 PMID 15135171
  • Direct probing of copper active site and free radical formed during bicarbonate-dependent peroxidase activity of bovine and human copper, zinc-superoxide dismutases. Low-temperature electron paramagnetic resonance and electron nuclear double resonance studies. (Karunakaran C, Zhang H, Crow JP, Antholine WE, Kalyanaraman B) J Biol Chem 2004 Jul 30;279(31):32534-40 PMID 15123612
  • Ceramide-induced intracellular oxidant formation, iron signaling, and apoptosis in endothelial cells: protective role of endogenous nitric oxide. (Matsunaga T, Kotamraju S, Kalivendi SV, Dhanasekaran A, Joseph J, Kalyanaraman B) J Biol Chem 2004 Jul 2;279(27):28614-24 PMID 15102832
  • Doxorubicin induces apoptosis in normal and tumor cells via distinctly different mechanisms. intermediacy of H(2)O(2)- and p53-dependent pathways. (Wang S, Konorev EA, Kotamraju S, Joseph J, Kalivendi S, Kalyanaraman B) J Biol Chem 2004 Jun 11;279(24):25535-43 PMID 15054096
  • Oxidant-induced iron signaling in Doxorubicin-mediated apoptosis. (Kotamraju S, Kalivendi SV, Konorev E, Chitambar CR, Joseph J, Kalyanaraman B) Methods Enzymol 2004;378:362-82 PMID 15038980
  • Nitric oxide mitigates peroxide-induced iron-signaling, oxidative damage, and apoptosis in endothelial cells: role of proteasomal function? (Kotamraju S, Tampo Y, Kalivendi SV, Joseph J, Chitambar CR, Kalyanaraman B) Arch Biochem Biophys 2004 Mar 1;423(1):74-80 PMID 14989268
  • 1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric-oxide synthase-derived superoxide. (Shang T, Kotamraju S, Kalivendi SV, Hillard CJ, Kalyanaraman B) J Biol Chem 2004 Apr 30;279(18):19099-112 PMID 14752097
  • Alpha-synuclein up-regulation and aggregation during MPP+-induced apoptosis in neuroblastoma cells: intermediacy of transferrin receptor iron and hydrogen peroxide. (Kalivendi SV, Cunningham S, Kotamraju S, Joseph J, Hillard CJ, Kalyanaraman B) J Biol Chem 2004 Apr 9;279(15):15240-7 PMID 14742448
  • Bicarbonate enhances alpha-synuclein oligomerization and nitration: intermediacy of carbonate radical anion and nitrogen dioxide radical. (Andrekopoulos C, Zhang H, Joseph J, Kalivendi S, Kalyanaraman B) Biochem J 2004 Mar 1;378(Pt 2):435-47 PMID 14640973
  • Comparative investigation of superoxide trapping by cyclic nitrone spin traps: the use of singular value decomposition and multiple linear regression analysis. (Keszler A, Kalyanaraman B, Hogg N) Free Radic Biol Med 2003 Nov 1;35(9):1149-57 PMID 14572617
  • Rapid-onset endothelial dysfunction with adriamycin: evidence for a dysfunctional nitric oxide synthase. (Duquaine D, Hirsch GA, Chakrabarti A, Han Z, Kehrer C, Brook R, Joseph J, Schott A, Kalyanaraman B, Vasquez-Vivar J, Rajagopalan S) Vasc Med 2003 May;8(2):101-7 PMID 14518612
  • Nitric oxide inhibits H2O2-induced transferrin receptor-dependent apoptosis in endothelial cells: Role of ubiquitin-proteasome pathway. (Kotamraju S, Tampo Y, Keszler A, Chitambar CR, Joseph J, Haas AL, Kalyanaraman B) Proc Natl Acad Sci U S A 2003 Sep 16;100(19):10653-8 PMID 12958216
  • Mitochondrial sources of H2O2 generation play a key role in flow-mediated dilation in human coronary resistance arteries. (Liu Y, Zhao H, Li H, Kalyanaraman B, Nicolosi AC, Gutterman DD) Circ Res 2003 Sep 19;93(6):573-80 PMID 12919951
  • Reactive oxygen species induce reversible PECAM-1 tyrosine phosphorylation and SHP-2 binding. (Maas M, Wang R, Paddock C, Kotamraju S, Kalyanaraman B, Newman PJ, Newman DK) Am J Physiol Heart Circ Physiol 2003 Dec;285(6):H2336-44 PMID 12893640
  • Mechanisms of endotoxin tolerance in human intestinal microvascular endothelial cells. (Ogawa H, Rafiee P, Heidemann J, Fisher PJ, Johnson NA, Otterson MF, Kalyanaraman B, Pritchard KA Jr, Binion DG) J Immunol 2003 Jun 15;170(12):5956-64 PMID 12794122
  • Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide. (Zhao H, Kalivendi S, Zhang H, Joseph J, Nithipatikom K, Vásquez-Vivar J, Kalyanaraman B) Free Radic Biol Med 2003 Jun 1;34(11):1359-68 PMID 12757846
  • Spin traps: in vitro toxicity and stability of radical adducts. (Khan N, Wilmot CM, Rosen GM, Demidenko E, Sun J, Joseph J, O'Hara J, Kalyanaraman B, Swartz HM) Free Radic Biol Med 2003 Jun 1;34(11):1473-81 PMID 12757857
  • NO adducts in mammalian red blood cells: too much or too little? (Rassaf T, Bryan NS, Maloney RE, Specian V, Kelm M, Kalyanaraman B, Rodriguez J, Feelisch M) Nat Med 2003 May;9(5):481-2; author reply 482-3 PMID 12724738
  • Bicarbonate-dependent peroxidase activity of human Cu,Zn-superoxide dismutase induces covalent aggregation of protein: intermediacy of tryptophan-derived oxidation products. (Zhang H, Andrekopoulos C, Joseph J, Chandran K, Karoui H, Crow JP, Kalyanaraman B) J Biol Chem 2003 Jun 27;278(26):24078-89 PMID 12686560
  • 1-Methyl-4-phenylpyridinium accumulates in cerebellar granule neurons via organic cation transporter 3. (Shang T, Uihlein AV, Van Asten J, Kalyanaraman B, Hillard CJ) J Neurochem 2003 Apr;85(2):358-67 PMID 12675912
  • Pulmonary arterial endothelial cells affect the redox status of coenzyme Q0. (Audi SH, Zhao H, Bongard RD, Hogg N, Kettenhofen NJ, Kalyanaraman B, Dawson CA, Merker MP) Free Radic Biol Med 2003 Apr 1;34(7):892-907 PMID 12654478
  • The role of tetrahydrobiopterin in superoxide generation from eNOS: enzymology and physiological implications. (Vásquez-Vivar J, Kalyanaraman B, Martásek P) Free Radic Res 2003 Feb;37(2):121-7 PMID 12653200
  • 1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide. (Kalivendi SV, Kotamraju S, Cunningham S, Shang T, Hillard CJ, Kalyanaraman B) Biochem J 2003 Apr 1;371(Pt 1):151-64 PMID 12523938
  • Oxidative stress-induced iron signaling is responsible for peroxide-dependent oxidation of dichlorodihydrofluorescein in endothelial cells: role of transferrin receptor-dependent iron uptake in apoptosis. (Tampo Y, Kotamraju S, Chitambar CR, Kalivendi SV, Keszler A, Joseph J, Kalyanaraman B) Circ Res 2003 Jan 10;92(1):56-63 PMID 12522121
  • Transmembrane nitration of hydrophobic tyrosyl peptides. Localization, characterization, mechanism of nitration, and biological implications. (Zhang H, Bhargava K, Keszler A, Feix J, Hogg N, Joseph J, Kalyanaraman B) J Biol Chem 2003 Mar 14;278(11):8969-78 PMID 12519728
  • Altered tetrahydrobiopterin metabolism in atherosclerosis: implications for use of oxidized tetrahydrobiopterin analogues and thiol antioxidants. (Vásquez-Vivar J, Duquaine D, Whitsett J, Kalyanaraman B, Rajagopalan S) Arterioscler Thromb Vasc Biol 2002 Oct 1;22(10):1655-61 PMID 12377745
  • Paradoxical effects of metalloporphyrins on doxorubicin-induced apoptosis: scavenging of reactive oxygen species versus induction of heme oxygenase-1. (Konorev EA, Kotamraju S, Zhao H, Kalivendi S, Joseph J, Kalyanaraman B) Free Radic Biol Med 2002 Oct 1;33(7):988 PMID 12361808
  • Nitration of PECAM-1 ITIM tyrosines abrogates phosphorylation and SHP-2 binding. (Newman DK, Hoffman S, Kotamraju S, Zhao T, Wakim B, Kalyanaraman B, Newman PJ) Biochem Biophys Res Commun 2002 Sep 6;296(5):1171-9 PMID 12207897
  • Doxorubicin-induced apoptosis: implications in cardiotoxicity. (Kalyanaraman B, Joseph J, Kalivendi S, Wang S, Konorev E, Kotamraju S) Mol Cell Biochem 2002 May-Jun;234-235(1-2):119-24 PMID 12162424
  • Activation of nuclear factor-kappaB during doxorubicin-induced apoptosis in endothelial cells and myocytes is pro-apoptotic: the role of hydrogen peroxide. (Wang S, Kotamraju S, Konorev E, Kalivendi S, Joseph J, Kalyanaraman B) Biochem J 2002 Nov 1;367(Pt 3):729-40 PMID 12139490
  • The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study. (Vásquez-Vivar J, Martásek P, Whitsett J, Joseph J, Kalyanaraman B) Biochem J 2002 Mar 15;362(Pt 3):733-9 PMID 11879202
  • Metal-independent production of hydroxyl radicals by halogenated quinones and hydrogen peroxide: an ESR spin trapping study. (Zhu BZ, Zhao HT, Kalyanaraman B, Frei B) Free Radic Biol Med 2002 Mar 1;32(5):465-73 PMID 11864786
  • Transferrin receptor-dependent iron uptake is responsible for doxorubicin-mediated apoptosis in endothelial cells: role of oxidant-induced iron signaling in apoptosis. (Kotamraju S, Chitambar CR, Kalivendi SV, Joseph J, Kalyanaraman B) J Biol Chem 2002 May 10;277(19):17179-87 PMID 11856741
  • Bicarbonate enhances nitration and oxidation reactions in biological systems--role of reactive oxygen and nitrogen species. (Kalyanaraman B, Joseph J, Zhang H) Adv Exp Med Biol 2001;500:175-82 PMID 11764932
  • Antioxidant mechanisms of isoflavones in lipid systems: paradoxical effects of peroxyl radical scavenging. (Patel RP, Boersma BJ, Crawford JH, Hogg N, Kirk M, Kalyanaraman B, Parks DA, Barnes S, Darley-Usmar V) Free Radic Biol Med 2001 Dec 15;31(12):1570-81 PMID 11744331
  • (-)-Epicatechin inhibits nitration and dimerization of tyrosine in hydrophilic as well as hydrophobic environments. (Schroeder P, Zhang H, Klotz LO, Kalyanaraman B, Sies H) Biochem Biophys Res Commun 2001 Dec 21;289(5):1334-8 PMID 11741342
  • Bicarbonate enhances peroxidase activity of Cu,Zn-superoxide dismutase. Role of carbonate anion radical and scavenging of carbonate anion radical by metalloporphyrin antioxidant enzyme mimetics. (Zhang H, Joseph J, Gurney M, Becker D, Kalyanaraman B) J Biol Chem 2002 Jan 11;277(2):1013-20 PMID 11682485
  • Reaction of tetrahydrobiopterin with superoxide: EPR-kinetic analysis and characterization of the pteridine radical. (Vásquez-Vivar J, Whitsett J, Martásek P, Hogg N, Kalyanaraman B) Free Radic Biol Med 2001 Oct 15;31(8):975-85 PMID 11595382
  • Doxorubicin-induced apoptosis is associated with increased transcription of endothelial nitric-oxide synthase. Effect of antiapoptotic antioxidants and calcium. (Kalivendi SV, Kotamraju S, Zhao H, Joseph J, Kalyanaraman B) J Biol Chem 2001 Dec 14;276(50):47266-76 PMID 11579094
  • Synthesis and biochemical applications of a solid cyclic nitrone spin trap: a relatively superior trap for detecting superoxide anions and glutathiyl radicals. (Zhao H, Joseph J, Zhang H, Karoui H, Kalyanaraman B) Free Radic Biol Med 2001 Sep 1;31(5):599-606 PMID 11522444
  • Nitration and oxidation of a hydrophobic tyrosine probe by peroxynitrite in membranes: comparison with nitration and oxidation of tyrosine by peroxynitrite in aqueous solution. (Zhang H, Joseph J, Feix J, Hogg N, Kalyanaraman B) Biochemistry 2001 Jun 26;40(25):7675-86 PMID 11412121
  • Inhibition of oxidized low-density lipoprotein-induced apoptosis in endothelial cells by nitric oxide. Peroxyl radical scavenging as an antiapoptotic mechanism. (Kotamraju S, Hogg N, Joseph J, Keefer LK, Kalyanaraman B) J Biol Chem 2001 May 18;276(20):17316-23 PMID 11278975
  • Nitric oxide activates the sarcolemmal K(ATP) channel in normoxic and chronically hypoxic hearts by a cyclic GMP-dependent mechanism. (Baker JE, Contney SJ, Singh R, Kalyanaraman B, Gross GJ, Bosnjak ZJ) J Mol Cell Cardiol 2001 Feb;33(2):331-41 PMID 11162137
  • Chronic myocardial hypoxia increases nitric oxide synthase and decreases caveolin-3. (Shi Y, Pritchard KA Jr, Holman P, Rafiee P, Griffith OW, Kalyanaraman B, Baker JE) Free Radic Biol Med 2000 Oct 15;29(8):695-703 PMID 11053770
  • Bicarbonate exacerbates oxidative injury induced by antitumor antibiotic doxorubicin in cardiomyocytes. (Konorev EA, Zhang H, Joseph J, Kennedy MC, Kalyanaraman B) Am J Physiol Heart Circ Physiol 2000 Nov;279(5):H2424-30 PMID 11045980
  • Generation of superoxide from nitric oxide synthase. (Vásquez-Vivar J, Kalyanaraman B) FEBS Lett 2000 Sep 22;481(3):305-6 PMID 11041680
  • Chromium (VI) increases endothelial cell expression of ICAM-1 and decreases nitric oxide activity. (Pritchard KA Jr, Ackerman A, Kalyanaraman B) J Environ Pathol Toxicol Oncol 2000;19(3):251-60 PMID 10983891
  • Modification of creatine kinase by S-nitrosothiols: S-nitrosation vs. S-thiolation. (Konorev EA, Kalyanaraman B, Hogg N) Free Radic Biol Med 2000 Jun 1;28(11):1671-8 PMID 10938464
  • The use of NO gas in biological systems. (Hogg N, Kalyanaraman B) Methods Mol Biol 1998;100:231-6 PMID 10907008
  • Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen. Role of reactive oxygen and nitrogen species. (Kotamraju S, Konorev EA, Joseph J, Kalyanaraman B) J Biol Chem 2000 Oct 27;275(43):33585-92 PMID 10899161
  • Peroxynitrite reversibly inhibits Ca(2+)-activated K(+) channels in rat cerebral artery smooth muscle cells. (Brzezinska AK, Gebremedhin D, Chilian WM, Kalyanaraman B, Elliott SJ) Am J Physiol Heart Circ Physiol 2000 Jun;278(6):H1883-90 PMID 10843885
  • Detection of superoxide anion using an isotopically labeled nitrone spin trap: potential biological applications. (Zhang H, Joseph J, Vasquez-Vivar J, Karoui H, Nsanzumuhire C, Martásek P, Tordo P, Kalyanaraman B) FEBS Lett 2000 May 4;473(1):58-62 PMID 10802059
  • Bicarbonate enhances the hydroxylation, nitration, and peroxidation reactions catalyzed by copper, zinc superoxide dismutase. Intermediacy of carbonate anion radical. (Zhang H, Joseph J, Felix C, Kalyanaraman B) J Biol Chem 2000 May 12;275(19):14038-45 PMID 10799477
  • Mitochondrial aconitase is a source of hydroxyl radical. An electron spin resonance investigation. (Vasquez-Vivar J, Kalyanaraman B, Kennedy MC) J Biol Chem 2000 May 12;275(19):14064-9 PMID 10799480
  • Effect of redox-active drugs on superoxide generation from nitric oxide synthases: biological and toxicological implications. (Vásquez-Vivar J, Hogg N, Martásek P, Karoui H, Tordo P, Pritchard KA Jr, Kalyanaraman B) Free Radic Res 1999 Dec;31(6):607-17 PMID 10630684
  • Reactions of *NO, *NO2 and peroxynitrite in membranes: physiological implications. (Goss SP, Singh RJ, Hogg N, Kalyanaraman B) Free Radic Res 1999 Dec;31(6):597-606 PMID 10630683
  • Mechanism of superoxide dismutase/H(2)O(2)-mediated nitric oxide release from S-nitrosoglutathione--role of glutamate. (Singh RJ, Hogg N, Goss SP, Antholine WE, Kalyanaraman B) Arch Biochem Biophys 1999 Dec 1;372(1):8-15 PMID 10562411
  • Bicarbonate enhances the peroxidase activity of Cu,Zn-superoxide dismutase. Role of carbonate anion radical. (Goss SP, Singh RJ, Kalyanaraman B) J Biol Chem 1999 Oct 1;274(40):28233-9 PMID 10497178
  • Tetrahydrobiopterin-dependent inhibition of superoxide generation from neuronal nitric oxide synthase. (Vásquez-Vivar J, Hogg N, Martásek P, Karoui H, Pritchard KA Jr, Kalyanaraman B) J Biol Chem 1999 Sep 17;274(38):26736-42 PMID 10480877
  • Cell-permeable superoxide dismutase and glutathione peroxidase mimetics afford superior protection against doxorubicin-induced cardiotoxicity: the role of reactive oxygen and nitrogen intermediates. (Konorev EA, Kennedy MC, Kalyanaraman B) Arch Biochem Biophys 1999 Aug 15;368(2):421-8 PMID 10441396
  • Adaptation to chronic hypoxia confers tolerance to subsequent myocardial ischemia by increased nitric oxide production. (Baker JE, Holman P, Kalyanaraman B, Griffith OW, Pritchard KA Jr) Ann N Y Acad Sci 1999 Jun 30;874:236-53 PMID 10415535
  • Biochemical characterization of human S-nitrosohemoglobin. Effects on oxygen binding and transnitrosation. (Patel RP, Hogg N, Spencer NY, Kalyanaraman B, Matalon S, Darley-Usmar VM) J Biol Chem 1999 May 28;274(22):15487-92 PMID 10336440
  • Nitric oxide and lipid peroxidation. (Hogg N, Kalyanaraman B) Biochim Biophys Acta 1999 May 5;1411(2-3):378-84 PMID 10320670
  • Characterization of the adduct formed from the reaction between homocysteine thiolactone and low-density lipoprotein: antioxidant implications. (Ferguson E, Hogg N, Antholine WE, Joseph J, Singh RJ, Parthasarathy S, Kalyanaraman B) Free Radic Biol Med 1999 Apr;26(7-8):968-77 PMID 10232841
  • The effect of alpha-tocopherol on the nitration of gamma-tocopherol by peroxynitrite. (Goss SP, Hogg N, Kalyanaraman B) Arch Biochem Biophys 1999 Mar 15;363(2):333-40 PMID 10068456
  • Electron spin resonance spin-trapping detection of superoxide generated by neuronal nitric oxide synthase. (Vásquez-Vivar J, Martásek P, Hogg N, Karoui H, Masters BS, Pritchard KA Jr, Kalyanaraman B) Methods Enzymol 1999;301:169-77 PMID 9919565
  • Antioxidant effects of nitric oxide and nitric oxide donor compounds on low-density lipoprotein oxidation. (Goss SP, Kalyanaraman B, Hogg N) Methods Enzymol 1999;301:444-53 PMID 9919593
  • Adaptation of hearts to chronic hypoxia increases tolerance to subsequent ischemia by increased nitric oxide production. (Baker JE, Holman P, Kalyanaraman B, Pritchard KA Jr) Adv Exp Med Biol 1998;454:203-17 PMID 9889894
  • The peroxynitrite generator, SIN-1, becomes a nitric oxide donor in the presence of electron acceptors. (Singh RJ, Hogg N, Joseph J, Konorev E, Kalyanaraman B) Arch Biochem Biophys 1999 Jan 15;361(2):331-9 PMID 9882464
  • Depletion of nitric oxide causes cell cycle alterations, apoptosis, and oxidative stress in pulmonary cells. (Janssen YM, Soultanakis R, Steece K, Heerdt E, Singh RJ, Joseph J, Kalyanaraman B) Am J Physiol 1998 Dec;275(6 Pt 1):L1100-9 PMID 9843847
  • Nitration of gamma-tocopherol and oxidation of alpha-tocopherol by copper-zinc superoxide dismutase/H2O2/NO2-: role of nitrogen dioxide free radical. (Singh RJ, Goss SP, Joseph J, Kalyanaraman B) Proc Natl Acad Sci U S A 1998 Oct 27;95(22):12912-7 PMID 9789014
  • Nitric oxide and low-density lipoprotein oxidation. (Hogg N, Kalyanaraman B) Free Radic Res 1998 Jun;28(6):593-600 PMID 9736311
  • Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors. (Vásquez-Vivar J, Kalyanaraman B, Martásek P, Hogg N, Masters BS, Karoui H, Tordo P, Pritchard KA Jr) Proc Natl Acad Sci U S A 1998 Aug 4;95(16):9220-5 PMID 9689061
  • Electron spin resonance analysis of heme-nitrosyl and reduced iron-sulfur centered complexes in allogeneic, heterotopic cardiac transplants: effects of treatment with pyrrolidine dithiocarbamate. (Nakanishi AL, Roza AM, Adams MB, Seibel R, Moore-Hilton G, Kalyanaraman B, Pieper GM) Free Radic Biol Med 1998 Jul 15;25(2):201-7 PMID 9667497
  • Reexamination of the mechanism of hydroxyl radical adducts formed from the reaction between familial amyotrophic lateral sclerosis-associated Cu,Zn superoxide dismutase mutants and H2O2. (Singh RJ, Karoui H, Gunther MR, Beckman JS, Mason RP, Kalyanaraman B) Proc Natl Acad Sci U S A 1998 Jun 9;95(12):6675-80 PMID 9618471
  • Rapid and irreversible inhibition of creatine kinase by peroxynitrite. (Konorev EA, Hogg N, Kalyanaraman B) FEBS Lett 1998 May 8;427(2):171-4 PMID 9607305
  • Generation and initial characterization of a novel polyclonal antibody directed against homocysteine thiolactone-modified low density lipoprotein. (Ferguson E, Parthasarathy S, Joseph J, Kalyanaraman B) J Lipid Res 1998 Apr;39(4):925-33 PMID 9555955
  • Endothelial cells prevent accumulation of lipid hydroperoxides in low-density lipoprotein. (Smalley DM, Hogg N, Kalyanaraman B, Pritchard KA Jr) Arterioscler Thromb Vasc Biol 1997 Dec;17(12):3469-74 PMID 9437194
  • Endothelial nitric oxide synthase-dependent superoxide generation from adriamycin. (Vásquez-Vivar J, Martasek P, Hogg N, Masters BS, Pritchard KA Jr, Kalyanaraman B) Biochemistry 1997 Sep 23;36(38):11293-7 PMID 9333325
  • The effect of nitric oxide release rates on the oxidation of human low density lipoprotein. (Goss SP, Hogg N, Kalyanaraman B) J Biol Chem 1997 Aug 22;272(34):21647-53 PMID 9261188
  • Spin-trapping of free radicals formed during the oxidation of glutathione by tetramethylammonium peroxynitrite. (Karoui H, Hansert B, Sand PJ, Tordo P, Bohle DS, Kalyanaraman B) Nitric Oxide 1997 Aug;1(4):346-58 PMID 9441906
  • The mechanism of apolipoprotein B-100 thiol depletion during oxidative modification of low-density lipoprotein. (Ferguson E, Singh RJ, Hogg N, Kalyanaraman B) Arch Biochem Biophys 1997 May 15;341(2):287-94 PMID 9169017
  • S-Nitrosoglutathione as a substrate for gamma-glutamyl transpeptidase. (Hogg N, Singh RJ, Konorev E, Joseph J, Kalyanaraman B) Biochem J 1997 Apr 15;323 ( Pt 2):477-81 PMID 9163341
  • Superoxide anion formation from lucigenin: an electron spin resonance spin-trapping study. (Vásquez-Vivar J, Hogg N, Pritchard KA Jr, Martasek P, Kalyanaraman B) FEBS Lett 1997 Feb 17;403(2):127-30 PMID 9042951
  • Spin label oximetry to assess extracellular oxygen during myocardial ischemia. (Baker JE, Froncisz W, Joseph J, Kalyanaraman B) Free Radic Biol Med 1997;22(1-2):109-15 PMID 8958135
  • Nitric oxide: a prostaglandin H synthase 1 and 2 reducing cosubstrate that does not stimulate cyclooxygenase activity or prostaglandin H synthase expression in murine macrophages. (Curtis JF, Reddy NG, Mason RP, Kalyanaraman B, Eling TE) Arch Biochem Biophys 1996 Nov 15;335(2):369-76 PMID 8914934
  • Detection of thiyl radical adducts formed during hydroxyl radical- and peroxynitrite-mediated oxidation of thiols--a high resolution ESR spin-trapping study at Q-band (35 GHz). (Kalyanaraman B, Karoui H, Singh RJ, Felix CC) Anal Biochem 1996 Oct 1;241(1):75-81 PMID 8921168
  • The mechanism of cardioprotection by S-nitrosoglutathione monoethyl ester in rat isolated heart during cardioplegic ischaemic arrest. (Konorev EA, Joseph J, Tarpey MM, Kalyanaraman B) Br J Pharmacol 1996 Oct;119(3):511-8 PMID 8894171
  • Mechanism of nitric oxide release from S-nitrosothiols. (Singh RJ, Hogg N, Joseph J, Kalyanaraman B) J Biol Chem 1996 Aug 2;271(31):18596-603 PMID 8702510
  • The reaction between nitric oxide and alpha-tocopherol: a reappraisal. (Hogg N, Singh RJ, Goss SP, Kalyanaraman B) Biochem Biophys Res Commun 1996 Jul 25;224(3):696-702 PMID 8713109
  • Effect of superoxide dismutase mimics on radical adduct formation during the reaction between peroxynitrite and thiols--an ESR-spin trapping study. (Karoui H, Hogg N, Joseph J, Kalyanaraman B) Arch Biochem Biophys 1996 Jun 1;330(1):115-24 PMID 8651684
  • The role of glutathione in the transport and catabolism of nitric oxide. (Hogg N, Singh RJ, Kalyanaraman B) FEBS Lett 1996 Mar 18;382(3):223-8 PMID 8605974
  • Characterization of sulfur-centered radical intermediates formed during the oxidation of thiols and sulfite by peroxynitrite. ESR-spin trapping and oxygen uptake studies. (Karoui H, Hogg N, Fréjaville C, Tordo P, Kalyanaraman B) J Biol Chem 1996 Mar 15;271(11):6000-9 PMID 8626383
  • S-nitrosoglutathione induces formation of nitrosylmyoglobin in isolated hearts during cardioplegic ischemia--an electron spin resonance study. (Konorev EA, Joseph J, Kalyanaraman B) FEBS Lett 1996 Jan 8;378(2):111-4 PMID 8549814
  • Detection of nitric oxide by electron spin resonance in chemical, photochemical, cellular, physiological, and pathophysiological systems. (Kalyanaraman B) Methods Enzymol 1996;268:168-87 PMID 8782583
  • Interaction of nitric oxide with photoexcited rose bengal: evidence for one-electron reduction of nitric oxide to nitroxyl anion. (Singh RJ, Hogg N, Kalyanaraman B) Arch Biochem Biophys 1995 Dec 20;324(2):367-73 PMID 8554328
  • Nitric oxide inhibition of lipoxygenase-dependent liposome and low-density lipoprotein oxidation: termination of radical chain propagation reactions and formation of nitrogen-containing oxidized lipid derivatives. (Rubbo H, Parthasarathy S, Barnes S, Kirk M, Kalyanaraman B, Freeman BA) Arch Biochem Biophys 1995 Dec 1;324(1):15-25 PMID 7503550
  • Inhibition of macrophage-dependent low density lipoprotein oxidation by nitric-oxide donors. (Hogg N, Struck A, Goss SP, Santanam N, Joseph J, Parthasarathy S, Kalyanaraman B) J Lipid Res 1995 Aug;36(8):1756-62 PMID 7595096
  • Detection by ESR of DMPO hydroxyl adduct formation from islets of Langerhans. (Pieper GM, Felix CC, Kalyanaraman B, Turk M, Roza AM) Free Radic Biol Med 1995 Aug;19(2):219-25 PMID 7649493
  • The antioxidant effect of spermine NONOate in human low-density lipoprotein. (Goss SP, Hogg N, Kalyanaraman B) Chem Res Toxicol 1995 Jul-Aug;8(5):800-6 PMID 7548764
  • Radical intermediates during degradation of lignin-model compounds and environmental pollutants: an electron spin resonance study. (Kalyanaraman B) Xenobiotica 1995 Jul;25(7):667-75 PMID 7483665
  • S-nitrosoglutathione improves functional recovery in the isolated rat heart after cardioplegic ischemic arrest-evidence for a cardioprotective effect of nitric oxide. (Konorev EA, Tarpey MM, Joseph J, Baker JE, Kalyanaraman B) J Pharmacol Exp Ther 1995 Jul;274(1):200-6 PMID 7616400
  • Spin-labeling study of the oxidative damage to low-density lipoprotein. (Singh RJ, Feix JB, Mchaourab HS, Hogg N, Kalyanaraman B) Arch Biochem Biophys 1995 Jun 20;320(1):155-61 PMID 7793976
  • Role of apolipoprotein B-derived radical and alpha-tocopheroxyl radical in peroxidase-dependent oxidation of low density lipoprotein. (Kalyanaraman B, Darley-Usmar V, Struck A, Hogg N, Parthasarathy S) J Lipid Res 1995 May;36(5):1037-45 PMID 7658151
  • Trapping of nitric oxide formed during photolysis of sodium nitroprusside in aqueous and lipid phases: an electron spin resonance study. (Singh RJ, Hogg N, Neese F, Joseph J, Kalyanaraman B) Photochem Photobiol 1995 Apr;61(4):325-30 PMID 7740075
  • Nitric oxide donor compounds inhibit the toxicity of oxidized low-density lipoprotein to endothelial cells. (Struck AT, Hogg N, Thomas JP, Kalyanaraman B) FEBS Lett 1995 Mar 20;361(2-3):291-4 PMID 7698340
  • Photosensitized decomposition of S-nitrosothiols and 2-methyl-2-nitrosopropane. Possible use for site-directed nitric oxide production. (Singh RJ, Hogg N, Joseph J, Kalyanaraman B) FEBS Lett 1995 Feb 20;360(1):47-51 PMID 7875299
  • Nitronyl nitroxides as probes to study the mechanism of vasodilatory action of nitrovasodilators, nitrone spin traps, and nitroxides: role of nitric oxide. (Konorev EA, Tarpey MM, Joseph J, Baker JE, Kalyanaraman B) Free Radic Biol Med 1995 Feb;18(2):169-77 PMID 7744299
  • Reactions of nitric oxide with nitronyl nitroxides and oxygen: prediction of nitrite and nitrate formation by kinetic simulation. (Hogg N, Singh RJ, Joseph J, Neese F, Kalyanaraman B) Free Radic Res 1995 Jan;22(1):47-56 PMID 7889147
  • Thiyl radicals in biological systems: significant or trivial? (Kalyanaraman B) Biochem Soc Symp 1995;61:55-63 PMID 8660403
  • Physical and chemical interactions between nitric oxide and nitroxides. (Singh RJ, Hogg N, Mchaourab HS, Kalyanaraman B) Biochim Biophys Acta 1994 Dec 15;1201(3):437-41 PMID 7803474
  • Involvement of preexisting lipid hydroperoxides in Cu(2+)-stimulated oxidation of low-density lipoprotein. (Thomas JP, Kalyanaraman B, Girotti AW) Arch Biochem Biophys 1994 Dec;315(2):244-54 PMID 7986064
  • Multiple mechanisms for inhibition of low density lipoprotein oxidation by novel cyclic nitrone spin traps. (Thomas CE, Ohlweiler DF, Kalyanaraman B) J Biol Chem 1994 Nov 11;269(45):28055-61 PMID 7961741
  • Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives. (Rubbo H, Radi R, Trujillo M, Telleri R, Kalyanaraman B, Barnes S, Kirk M, Freeman BA) J Biol Chem 1994 Oct 21;269(42):26066-75 PMID 7929318
  • The oxidation of alpha-tocopherol and trolox by peroxynitrite. (Hogg N, Joseph J, Kalyanaraman B) Arch Biochem Biophys 1994 Oct;314(1):153-8 PMID 7944387
  • Enhancement of merocyanine 540 uptake and photodynamic cell killing by salicylates. (Feix JB, Anderson MS, Kalyanaraman B) Cancer Res 1994 Jul 1;54(13):3474-8 PMID 8012969
  • Nitrone spin trap lipophilicity as a determinant for inhibition of low density lipoprotein oxidation and activation of interleukin-1 beta release from human monocytes. (Thomas CE, Ku G, Kalyanaraman B) J Lipid Res 1994 Apr;35(4):610-9 PMID 8006515
  • Lack of protection of PBN in isolated heart during ischemia and reperfusion: implications for radical scavenging mechanism. (Baker JE, Konorev EA, Tse SY, Joseph J, Kalyanaraman B) Free Radic Res 1994 Mar;20(3):145-63 PMID 8019639
  • Inhibition of low-density lipoprotein oxidation by nitric oxide. Potential role in atherogenesis. (Hogg N, Kalyanaraman B, Joseph J, Struck A, Parthasarathy S) FEBS Lett 1993 Nov 15;334(2):170-4 PMID 8224243
  • Peroxynitrite modification of low-density lipoprotein leads to recognition by the macrophage scavenger receptor. (Graham A, Hogg N, Kalyanaraman B, O'Leary V, Darley-Usmar V, Moncada S) FEBS Lett 1993 Sep 13;330(2):181-5 PMID 8365489
  • Spin trapping of nitrogen dioxide radical from photolytic decomposition of nitramines. (Pace MD, Kalyanaraman B) Free Radic Biol Med 1993 Sep;15(3):337-42 PMID 8406133
  • Site-specific trapping of reactive species in low-density lipoprotein oxidation: biological implications. (Kalyanaraman B, Joseph J, Parthasarathy S) Biochim Biophys Acta 1993 Jun 12;1168(2):220-7 PMID 8389205
  • Free radicals in toxicology. (Aust SD, Chignell CF, Bray TM, Kalyanaraman B, Mason RP) Toxicol Appl Pharmacol 1993 Jun;120(2):168-78 PMID 8511786
  • The use of spin traps to investigate site-specific formation of free radicals in low-density lipoprotein oxidation. (Kalyanaraman B, Joseph J, Parthasarathy S) Biochem Soc Trans 1993 May;21(2):318-21 PMID 8395423
  • Trapping of nitric oxide by nitronyl nitroxides: an electron spin resonance investigation. (Joseph J, Kalyanaraman B, Hyde JS) Biochem Biophys Res Commun 1993 Apr 30;192(2):926-34 PMID 8387295
  • Enhancement of merocyanine 540-mediated phototherapy by salicylate. (Anderson MS, Kalyanaraman B, Feix JB) Cancer Res 1993 Feb 15;53(4):806-9 PMID 8381329
  • Vasodilatory and toxic effects of spin traps on aerobic cardiac function. (Konorev EA, Baker JE, Joseph J, Kalyanaraman B) Free Radic Biol Med 1993 Feb;14(2):127-37 PMID 8425719
  • Intracellular catalase inhibition does not predispose rat heart to ischemia-reperfusion and hydrogen peroxide-induced injuries. (Konorev EA, Struck AT, Baker JE, Ramanujam S, Thomas JP, Radi R, Kalyanaraman B) Free Radic Res Commun 1993;19(6):397-407 PMID 8168729
  • Direct modification of low density lipoprotein by the spin trap 3,5-dibromo-4-nitrosobenzenesulfonic acid. (Kalyanaraman B, Joseph J, Kondratenko N, Parthasarathy S) Biochim Biophys Acta 1992 Jun 26;1126(3):309-13 PMID 1322177
  • Evidence for the formation of a quinone methide during the oxidation of the insect cuticular sclerotizing precursor 1,2-dehydro-N-acetyldopamine. (Sugumaran M, Semensi V, Kalyanaraman B, Bruce JM, Land EJ) J Biol Chem 1992 May 25;267(15):10355-61 PMID 1316899
  • Synergistic interaction between the probucol phenoxyl radical and ascorbic acid in inhibiting the oxidation of low density lipoprotein. (Kalyanaraman B, Darley-Usmar VM, Wood J, Joseph J, Parthasarathy S) J Biol Chem 1992 Apr 5;267(10):6789-95 PMID 1313022
  • Photobleaching of merocyanine 540: involvement of singlet molecular oxygen. (Singh RJ, Feix JB, Kalyanaraman B) Photochem Photobiol 1992 Apr;55(4):483-9 PMID 1620725
  • Production of singlet oxygen-derived hydroxyl radical adducts during merocyanine-540-mediated photosensitization: analysis by ESR-spin trapping and HPLC with electrochemical detection. (Feix JB, Kalyanaraman B) Arch Biochem Biophys 1991 Nov 15;291(1):43-51 PMID 1656888
  • Action spectra of the antileukemic and antiviral activities of merocyanine 540. (O'Brien JM, Singh RJ, Feix JB, Kalyanaraman B, Sieber F) Photochem Photobiol 1991 Nov;54(5):851-4 PMID 1665914
  • Xanthine oxidase-catalyzed reduction of estrogen quinones to semiquinones and hydroquinones. (Roy D, Kalyanaraman B, Liehr JG) Biochem Pharmacol 1991 Sep 27;42(8):1627-31 PMID 1656992
  • Detection of radical adducts of 5,5-dimethyl-1-pyrroline n-oxide by the combined use of high-performance liquid chromatography with electrochemical detection and electron spin resonance. (Towell J, Kalyanaraman B) Anal Biochem 1991 Jul;196(1):111-9 PMID 1653547
  • Characterization of the pigment from homogentisic acid and urine and tissue from an alkaptonuria patient. (Menon IA, Persad SD, Haberman HF, Basu PK, Norfray JF, Felix CC, Kalyanaraman B) Biochem Cell Biol 1991 Apr;69(4):269-73 PMID 1647170
  • An electron paramagnetic resonance study of the interactions between the adriamycin semiquinone, hydrogen peroxide, iron-chelators, and radical scavengers. (Kalyanaraman B, Morehouse KM, Mason RP) Arch Biochem Biophys 1991 Apr;286(1):164-70 PMID 1654778
  • Photodynamic action of merocyanine 540 in artificial bilayers and natural membranes: action spectra and quantum yields. (Singh RJ, Feix JB, Pintar TJ, Girotti AW, Kalyanaraman B) Photochem Photobiol 1991 Apr;53(4):493-500 PMID 1857744
  • The spin trap, alpha-phenyl N-tert-butylnitrone, inhibits the oxidative modification of low density lipoprotein. (Kalyanaraman B, Joseph J, Parthasarathy S) FEBS Lett 1991 Mar 11;280(1):17-20 PMID 1849092
  • Spin-trapping studies of the oxidation-reduction reactions of iron bleomycin in the presence of thiols and buffer. (Antholine WE, Kalyanaraman B, Templin JA, Byrnes RW, Petering DH) Free Radic Biol Med 1991;10(2):119-23 PMID 1707847
  • An electron spin resonance study of merocyanine 540-mediated type I reactions in liposomes. (Feix JB, Kalyanaraman B) Photochem Photobiol 1991 Jan;53(1):39-45 PMID 1851304
  • Effects of hydroxyethyl starch conjugated deferoxamine on myocardial functional recovery following coronary occlusion and reperfusion in dogs. (Maruyama M, Pieper GM, Kalyanaraman B, Hallaway PE, Hedlund BE, Gross GJ) J Cardiovasc Pharmacol 1991 Jan;17(1):166-75 PMID 1708051
  • Lignin peroxidase oxidation of Mn2+ in the presence of veratryl alcohol, malonic or oxalic acid, and oxygen. (Popp JL, Kalyanaraman B, Kirk TK) Biochemistry 1990 Nov 20;29(46):10475-80 PMID 2176868
  • Copper ion-dependent oxy-radical mediated DNA damage from dihydroxy derivative of etoposide. (Sinha BK, Antholine WM, Kalyanaraman B, Eliot HM) Biochim Biophys Acta 1990 Nov 14;1096(1):81-3 PMID 2176549
  • Oxidation of low-density lipoprotein by Cu2+ and lipoxygenase: an electron spin resonance study. (Kalyanaraman B, Antholine WE, Parthasarathy S) Biochim Biophys Acta 1990 Sep 14;1035(3):286-92 PMID 2169886
  • Characterization of radical adducts formed during photochemical spin trapping in liposomes. (Sheng PG, Feix J, Kalyanaraman B) Photochem Photobiol 1990 Aug;52(2):323-31 PMID 2171003
  • Comparison of lignin peroxidase, horseradish peroxidase and laccase in the oxidation of methoxybenzenes. (Kersten PJ, Kalyanaraman B, Hammel KE, Reinhammar B, Kirk TK) Biochem J 1990 Jun 1;268(2):475-80 PMID 2163614
  • On the detection of paramagnetic species in the adriamycin-perfused rat heart: a reappraisal. (Kalyanaraman B, Baker JE) Biochem Biophys Res Commun 1990 May 31;169(1):30-8 PMID 2161659
  • An ESR study of the nitroxide radical of pentastarch-conjugated deferoxamine. (Pieper GM, Gross GJ, Kalyanaraman B) Free Radic Biol Med 1990;9(3):211-8 PMID 2177027
  • Characterization of o-semiquinone radicals in biological systems. (Kalyanaraman B) Methods Enzymol 1990;186:333-43 PMID 2172710
  • Spin trapping of lipid-derived radicals in liposomes. (Feix JB, Kalyanaraman B) Biochim Biophys Acta 1989 Aug 18;992(2):230-5 PMID 2547451
  • Evidence for the metabolism of tumor promoter organic hydroperoxides into free radicals by human carcinoma skin keratinocytes: an ESR-spin trapping study. (Athar M, Mukhtar H, Bickers DR, Khan IU, Kalyanaraman B) Carcinogenesis 1989 Aug;10(8):1499-503 PMID 2473853
  • Characterization of semiquinone free radicals formed from stilbene catechol estrogens. An ESR spin stabilization and spin trapping study. (Kalyanaraman B, Sealy RC, Liehr JG) J Biol Chem 1989 Jul 5;264(19):11014-9 PMID 2544580
  • Characterization of free radicals produced during oxidation of etoposide (VP-16) and its catechol and quinone derivatives. An ESR Study. (Kalyanaraman B, Nemec J, Sinha BK) Biochemistry 1989 May 30;28(11):4839-46 PMID 2548593
  • Ischemia-induced changes in myocardial paramagnetic metabolites: implications for intracellular oxy-radical generation. (Baker JE, Kalyanaraman B) FEBS Lett 1989 Feb 27;244(2):311-4 PMID 2537756
  • Direct observation of singlet oxygen production by merocyanine 540 associated with phosphatidylcholine liposomes. (Feix JB, Kalyanaraman B, Chignell CF, Hall RD) J Biol Chem 1988 Nov 25;263(33):17247-50 PMID 3182846
  • Reaction between ortho-semiquinones and oxygen: pulse radiolysis, electron spin resonance, and oxygen uptake studies. (Kalyanaraman B, Korytowski W, Pilas B, Sarna T, Land EJ, Truscott TG) Arch Biochem Biophys 1988 Oct;266(1):277-84 PMID 2845864
  • Oxygen activation during the interaction between MPTP metabolites and synthetic neuromelanin--an ESR-spin trapping, optical, and oxidase electrode study. (Korytowski W, Felix CC, Kalyanaraman B) Biochem Biophys Res Commun 1988 Jul 29;154(2):781-8 PMID 2840906
  • Ligninase-mediated phenoxy radical formation and polymerization unaffected by cellobiose:quinone oxidoreductase. (Odier E, Mozuch MD, Kalyanaraman B, Kirk TK) Biochimie 1988 Jun;70(6):847-52 PMID 2844307
  • Myocardial ischemia and reperfusion: direct evidence for free radical generation by electron spin resonance spectroscopy. (Baker JE, Felix CC, Olinger GN, Kalyanaraman B) Proc Natl Acad Sci U S A 1988 Apr;85(8):2786-9 PMID 2833754
  • The effect of melanin on iron associated decomposition of hydrogen peroxide. (Pilas B, Sarna T, Kalyanaraman B, Swartz HM) Free Radic Biol Med 1988;4(5):285-93 PMID 2834276
  • Mechanism of oxidation of 1-methyl-4-phenyl-3,3-dihydropyridinium (MPDP+). (Kalyanaraman B, Korytowski W, Felix CC) Basic Life Sci 1988;49:781-5 PMID 3250532
  • The production of hydroxyl and semiquinone free radicals during the autoxidation of redox active flavonoids. (Hodnick WF, Kalyanaraman B, Pritsos CA, Pardini RS) Basic Life Sci 1988;49:149-52 PMID 2854978
  • Evidence for the one-electron oxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+). (Korytowski W, Felix CC, Kalyanaraman B) Biochem Biophys Res Commun 1987 Aug 31;147(1):354-60 PMID 3632675
  • Semiquinone anion radicals from addition of amino acids, peptides, and proteins to quinones derived from oxidation of catechols and catecholamines. An ESR spin stabilization study. (Kalyanaraman B, Premovic PI, Sealy RC) J Biol Chem 1987 Aug 15;262(23):11080-7 PMID 3038907
  • Is there any difference in the photobiological properties of melanins isolated from human blue and brown eyes? (Menon IA, Basu PK, Persad S, Avaria M, Felix CC, Kalyanaraman B) Br J Ophthalmol 1987 Jul;71(7):549-52 PMID 2820463
  • Tyrosinase-catalyzed oxidation of dopa and related catechol(amine)s: a kinetic electron spin resonance investigation using spin-stabilization and spin label oximetry. (Korytowski W, Sarna T, Kalyanaraman B, Sealy RC) Biochim Biophys Acta 1987 Jun 22;924(3):383-92 PMID 3036239
  • Photodynamic action of merocyanine 540 on artificial and natural cell membranes: involvement of singlet molecular oxygen. (Kalyanaraman B, Feix JB, Sieber F, Thomas JP, Girotti AW) Proc Natl Acad Sci U S A 1987 May;84(9):2999-3003 PMID 3033673
  • Mechanism of oxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+). (Korytowski W, Felix CC, Kalyanaraman B) Biochem Biophys Res Commun 1987 Apr 29;144(2):692-8 PMID 3579936
  • Photoinduced generation of hydrogen peroxide and hydroxyl radicals in melanins. (Korytowski W, Pilas B, Sarna T, Kalyanaraman B) Photochem Photobiol 1987 Feb;45(2):185-90 PMID 3031709
  • Interactions of the antitumor drug, etoposide, with reduced thiols in vitro and in vivo. (Katki AG, Kalyanaraman B, Sinha BK) Chem Biol Interact 1987;62(3):237-47 PMID 3040275
  • Oxidation of polycyclic aromatic hydrocarbons and dibenzo[p]-dioxins by Phanerochaete chrysosporium ligninase. (Hammel KE, Kalyanaraman B, Kirk TK) J Biol Chem 1986 Dec 25;261(36):16948-52 PMID 3023375
  • The use of spin label oximetry in the study of photodynamic inactivation of Chinese hamster ovary cells. (Ankel E, Felix CC, Kalyanaraman B) Photochem Photobiol 1986 Dec;44(6):741-6 PMID 3031706
  • Photolysis of pheomelanin precursors: an ESR-spin trapping study. (Pilas B, Felix CC, Sarna T, Kalyanaraman B) Photochem Photobiol 1986 Dec;44(6):689-96 PMID 3031704
  • An electron spin resonance study of free radicals from catechol estrogens. (Kalyanaraman B, Hintz P, Sealy RC) Fed Proc 1986 Sep;45(10):2477-84 PMID 3017766
  • Metal ion-induced activation of molecular oxygen in pigmented polymers. (Hintz P, Kalyanaraman B) Biochim Biophys Acta 1986 Aug 6;883(1):41-5 PMID 3015234
  • Reaction of superoxide anions with melanins: electron spin resonance and spin trapping studies. (Korytowski W, Kalyanaraman B, Menon IA, Sarna T, Sealy RC) Biochim Biophys Acta 1986 Jun 19;882(2):145-53 PMID 3011111
  • Substrate free radicals are intermediates in ligninase catalysis. (Hammel KE, Kalyanaraman B, Kirk TK) Proc Natl Acad Sci U S A 1986 Jun;83(11):3708-12 PMID 3012530
  • Ligninase of Phanerochaete chrysosporium. Mechanism of its degradation of the non-phenolic arylglycerol beta-aryl ether substructure of lignin. (Kirk TK, Tien M, Kersten PJ, Mozuch MD, Kalyanaraman B) Biochem J 1986 May 15;236(1):279-87 PMID 3024619
  • ESR of copper and iron complexes with antitumor and cytotoxic properties. (Antholine WE, Kalyanaraman B, Petering DH) Environ Health Perspect 1985 Dec;64:19-35 PMID 2420582
  • Semiquinone anion radicals of catechol(amine)s, catechol estrogens, and their metal ion complexes. (Kalyanaraman B, Felix CC, Sealy RC) Environ Health Perspect 1985 Dec;64:185-98 PMID 3007089
  • Free radical-mediated activation of hydrazine derivatives. (Kalyanaraman B, Sinha BK) Environ Health Perspect 1985 Dec;64:179-84 PMID 3007088
  • Mechanism of DNA strand breaks by mitonafide, an imide derivative of 3-nitro-1,8-naphthalic acid. (Sinha BK, Strong J, Gibson NW, Kalyanaraman B) Biochem Pharmacol 1985 Nov 1;34(21):3845-52 PMID 4062959
  • Mechanism of dismutation of superoxide produced during autoxidation of melanin pigments. (Korytowski W, Hintz P, Sealy RC, Kalyanaraman B) Biochem Biophys Res Commun 1985 Sep 16;131(2):659-65 PMID 2996521
  • Mechanism of oxidative C alpha-C beta cleavage of a lignin model dimer by Phanerochaete chrysosporium ligninase. Stoichiometry and involvement of free radicals. (Hammel KE, Tien M, Kalyanaraman B, Kirk TK) J Biol Chem 1985 Jul 15;260(14):8348-53 PMID 2989288
  • Microsomal interactions and inhibition of lipid peroxidation by etoposide (VP-16, 213): implications for mode of action. (Sinha BK, Trush MA, Kalyanaraman B) Biochem Pharmacol 1985 Jun 1;34(11):2036-40 PMID 4004921
  • Radical anions from one-electron-reduced adrenochrome. Detection and identification by electron spin resonance spectroscopy. (Prabhananda BS, Kalyanaraman B, Sealy RC) Biochim Biophys Acta 1985 May 29;840(1):21-8 PMID 2986709
  • Generation of free radical intermediates from foreign compounds by neutrophil-derived oxidants. (Kalyanaraman B, Sohnle PG) J Clin Invest 1985 May;75(5):1618-22 PMID 2987307
  • Spin trapping of the azidyl radical in azide/catalase/H2O2 and various azide/peroxidase/H2O2 peroxidizing systems. (Kalyanaraman B, Janzen EG, Mason RP) J Biol Chem 1985 Apr 10;260(7):4003-6 PMID 2984193
  • Free radicals from the photodecomposition of bleomycin. (Antholine WE, Sarna T, Sealy RC, Kalyanaraman B, Shields GD, Petering DH) Photochem Photobiol 1985 Apr;41(4):393-9 PMID 2409563
  • The ligninase of Phanerochaete chrysosporium generates cation radicals from methoxybenzenes. (Kersten PJ, Tien M, Kalyanaraman B, Kirk TK) J Biol Chem 1985 Mar 10;260(5):2609-12 PMID 2982828
  • An electron spin resonance study of o-semiquinones formed during the enzymatic and autoxidation of catechol estrogens. (Kalyanaraman B, Sealy RC, Sivarajah K) J Biol Chem 1984 Nov 25;259(22):14018-22 PMID 6094535
  • Identification by electron spin resonance spectroscopy of free radicals produced during autoxidative melanogenesis. (Sealy RC, Puzyna W, Kalyanaraman B, Felix CC) Biochim Biophys Acta 1984 Aug 21;800(3):269-76 PMID 6087915
  • An electron spin resonance study of the reduction of peroxides by anthracycline semiquinones. (Kalyanaraman B, Sealy RC, Sinha BK) Biochim Biophys Acta 1984 Jun 29;799(3):270-5 PMID 6329317
  • Peroxidatic oxidation of catecholamines. A kinetic electron spin resonance investigation using the spin stabilization approach. (Kalyanaraman B, Felix CC, Sealy RC) J Biol Chem 1984 Jun 25;259(12):7584-9 PMID 6330064
  • On the use of organic extraction in the spin-trapping technique as applied to biological systems. (Kalyanaraman B, Mottley C, Mason RP) J Biochem Biophys Methods 1984 Mar;9(1):27-31 PMID 6327794
  • Electron spin resonance-spin stabilization of semiquinones produced during oxidation of epinephrine and its analogues. (Kalyanaraman B, Felix CC, Sealy RC) J Biol Chem 1984 Jan 10;259(1):354-8 PMID 6323406
  • Free radical metabolism of VP-16 and inhibition of anthracycline-induced lipid peroxidation. (Sinha BK, Trush MA, Kalyanaraman B) Biochem Pharmacol 1983 Nov 15;32(22):3495-8 PMID 6651872
  • A free radical mediated cooxidation of tetramethylhydrazine by prostaglandin hydroperoxidase. (Kalyanaraman B, Sivarajah K, Eling TE, Mason RP) Carcinogenesis 1983 Oct;4(10):1341-3 PMID 6311452
  • A direct electron spin resonance and spin-trapping investigation of peroxyl free radical formation by hematin/hydroperoxide systems. (Kalyanaraman B, Mottley C, Mason RP) J Biol Chem 1983 Mar 25;258(6):3855-8 PMID 6300059
  • Electron spin resonance--spin stabilization in enzymatic systems: detection of semiquinones produced during peroxidatic oxidation of catechols and catecholamines. (Kalyanaraman B, Sealy RC) Biochem Biophys Res Commun 1982 Jun 30;106(4):1119-25 PMID 6288039
  • The free radical formed during the hydroperoxide-mediated deactivation of ram seminal vesicles is hemoprotein-derived. (Kalyanaraman B, Mason RP, Tainer B, Eling TE) J Biol Chem 1982 May 10;257(9):4764-8 PMID 6279648
  • An electron spin resonance study of the novel radical cation produced during the horseradish peroxidase-catalyzed oxidation of tetramethylhydrazine. (Kalyanaraman B, Mason RP, Sivarajah K) Biochem Biophys Res Commun 1982 Mar 15;105(1):217-24 PMID 6284143
  • Grants and Awards

  • Development of a Voxel-Wise Database of Physical Parameters for Neuroimaging (#9520205 05/01/2011 - 04/30/2014) Sponsor: AHW-Research and Education Program
  • Bicarbonate Enhances Peroxidation of SOD/ALS Mutants (#9203580 02/15/2005 - 01/31/2010) Sponsor: NIH Neurological Disorders and Stroke
  • eNOS & the Radical Mechanism of Antitumor Anthracyclines (#9202593 09/01/2002 - 08/31/2008) Sponsor: NIH Cancer Institute
  • Role of INOS, Nitric Oxide & Arginase in Statin-Mediated Toxicity in Cancer Cells (#9205206 07/01/2008 - 05/31/2014) Sponsor: NIH Cancer Institute
  • Development of Mitochondrially Targeted Antioxidants for Diabetic Therapy (#9204756 04/01/2007 - 03/31/2008) Sponsor: University of Alabama at Birmingham
  • Neuroprotection by Mitochondria-targeted Antioxidants (#9205495 02/01/2009 - 01/31/2015) Sponsor: NIH Neurological Disorders and Stroke
  • Mitochondria-Targeted Agents in Breast Cancer (#9206299 06/14/2010 - 04/30/2015) Sponsor: NIH Cancer Institute
  • Peroxide, NO and Iron Signaling in Endothelial Damage (#9202820 03/17/2003 - 02/28/2009) Sponsor: NIH Heart Lung and Blood Institute
  • Redox-Control of MMP-1 and Senescence (#9207548 04/01/2011 - 03/31/2014) Sponsor: University at Albany State University of New York
  • Mito-Q Attenuates DOX-induced Cardiotoxicity and Potentiates Antitumor Effects: Echocardiography Studies (#9303905 02/01/2007 - 06/30/2008) Sponsor: Antipodean Pharmaceuticals
  • Role of Neuronal NOS and Superoxide in Neurodegeneration (#9203267 04/01/2004 - 01/31/2009) Sponsor: NIH Neurological Disorders and Stroke
  • Vascular Signaling by Free Radicals (#9202434 04/01/2002 - 03/31/2008) PI of Vascular Signaling by Free Radicals-Core B (#2204044)